optics

Summary

Top Publications

  1. ncbi High-resolution imaging with adaptive optics in patients with inherited retinal degeneration
    Jacque L Duncan
    Department of Ophthalmology, University of California, San Francisco School of Medicine, San Francisco, California 94143 0730, USA
    Invest Ophthalmol Vis Sci 48:3283-91. 2007
  2. ncbi Developing optofluidic technology through the fusion of microfluidics and optics
    Demetri Psaltis
    Department of Electrical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Nature 442:381-6. 2006
  3. pmc Functional photoreceptor loss revealed with adaptive optics: an alternate cause of color blindness
    Joseph Carroll
    Center for Visual Science, University of Rochester, Rochester, NY 14627 0270, USA
    Proc Natl Acad Sci U S A 101:8461-6. 2004
  4. ncbi Inspirations from biological optics for advanced photonic systems
    Luke P Lee
    Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California, Berkeley, CA 94720 1762, USA
    Science 310:1148-50. 2005
  5. ncbi Interindividual variation of eye optics and single object resolution in bumblebees
    Johannes Spaethe
    Zoologie II, Biozentrum, University of Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    J Exp Biol 206:3447-53. 2003
  6. ncbi Integrated optics ring-resonator sensors for protein detection
    A Ksendzov
    Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, California 91109, USA
    Opt Lett 30:3344-6. 2005
  7. ncbi Evaluating the lateral resolution of the adaptive optics scanning laser ophthalmoscope
    Yuhua Zhang
    University of California, Berkeley, School of Optometry, Room 485, Minor Hall, Berkeley, California 94720 2020, USA
    J Biomed Opt 11:014002. 2006
  8. ncbi Advanced optics in a jellyfish eye
    Dan E Nilsson
    Department of Cell and Organism Biology, Lund University, Zoology Building, Helgonavagen 3, 22362 Lund, Sweden
    Nature 435:201-5. 2005
  9. ncbi Light microscopy techniques for live cell imaging
    David J Stephens
    Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    Science 300:82-6. 2003
  10. pmc Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high-speed transversal scanning optical coherence tomography
    M Pircher
    Center for Biomedical Engineering and Physics, Medical University of Vienna, Vienna, Austria
    Opt Lett 33:22-4. 2008

Detail Information

Publications229 found, 100 shown here

  1. ncbi High-resolution imaging with adaptive optics in patients with inherited retinal degeneration
    Jacque L Duncan
    Department of Ophthalmology, University of California, San Francisco School of Medicine, San Francisco, California 94143 0730, USA
    Invest Ophthalmol Vis Sci 48:3283-91. 2007
    ..To investigate macular photoreceptor structure in patients with inherited retinal degeneration using high-resolution images and to correlate the findings with clinical phenotypes and genetic mutations...
  2. ncbi Developing optofluidic technology through the fusion of microfluidics and optics
    Demetri Psaltis
    Department of Electrical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Nature 442:381-6. 2006
    We describe devices in which optics and fluidics are used synergistically to synthesize novel functionalities...
  3. pmc Functional photoreceptor loss revealed with adaptive optics: an alternate cause of color blindness
    Joseph Carroll
    Center for Visual Science, University of Rochester, Rochester, NY 14627 0270, USA
    Proc Natl Acad Sci U S A 101:8461-6. 2004
    ..Here, adaptive optics retinal imaging has revealed a mechanism for producing dichromatic color vision in which the expression of a ..
  4. ncbi Inspirations from biological optics for advanced photonic systems
    Luke P Lee
    Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California, Berkeley, CA 94720 1762, USA
    Science 310:1148-50. 2005
    ..tools, such as those for microscopic imaging and chemical analyses, have added to our understanding of biological optics. Biologically inspired optical science has become the emerging topic among researchers and scientists...
  5. ncbi Interindividual variation of eye optics and single object resolution in bumblebees
    Johannes Spaethe
    Zoologie II, Biozentrum, University of Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    J Exp Biol 206:3447-53. 2003
    ..resolving power is much stronger than that predicted by surveying ommatidial arrays, indicating that measuring eye optics alone is insufficient for predictions of single object resolution, unless combined with behavioural tests...
  6. ncbi Integrated optics ring-resonator sensors for protein detection
    A Ksendzov
    Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, California 91109, USA
    Opt Lett 30:3344-6. 2005
    Using an integrated optics ring-resonator biosensor, we have demonstrated the detection of protein in low concentrations. We detected 0.3 nM of avidin in a buffered saline solution; the calculated detection limit is 0.1 nM (6...
  7. ncbi Evaluating the lateral resolution of the adaptive optics scanning laser ophthalmoscope
    Yuhua Zhang
    University of California, Berkeley, School of Optometry, Room 485, Minor Hall, Berkeley, California 94720 2020, USA
    J Biomed Opt 11:014002. 2006
    We present a statistical assessment of the lateral resolution of the adaptive optics scanning laser ophthalmoscope (AOSLO)...
  8. ncbi Advanced optics in a jellyfish eye
    Dan E Nilsson
    Department of Cell and Organism Biology, Lund University, Zoology Building, Helgonavagen 3, 22362 Lund, Sweden
    Nature 435:201-5. 2005
    ..This demonstrates that even simple animals have been able to evolve the sophisticated visual optics previously known only from a few advanced bilaterian phyla...
  9. ncbi Light microscopy techniques for live cell imaging
    David J Stephens
    Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    Science 300:82-6. 2003
    ..For anyone new to this area, however, it can be daunting to decide which techniques or equipment to try. Here, we aim to give a brief overview of the main approaches to live cell imaging, with some mention of their pros and cons...
  10. pmc Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high-speed transversal scanning optical coherence tomography
    M Pircher
    Center for Biomedical Engineering and Physics, Medical University of Vienna, Vienna, Austria
    Opt Lett 33:22-4. 2008
    We describe a novel instrument capable of acquiring, simultaneously, adaptive optics enhanced scanning laser ophthalmoscopy and optical coherence tomography (OCT) images of the human cone mosaic in vivo...
  11. ncbi Effects of Zernike wavefront aberrations on visual acuity measured using electromagnetic adaptive optics technology
    Karolinne Maia Rocha
    Federal University of Sao Paulo, Sao Paulo, Brazil
    J Refract Surg 23:953-9. 2007
    ..This study measured the changes in visual acuity induced by individual Zernike ocular aberrations of various root-mean-square (RMS) magnitudes...
  12. ncbi Illumination, optics, and clinical performance of a hand-held magnified visual inspection device (AviScope): a comparison with colposcopy
    John W Sellors
    Program for Appropriate Technology in Health, Seattle, WA, USA
    J Acquir Immune Defic Syndr 37:S160-6. 2004
    Colposcopy is the reference standard for a visual inspection device in terms of illumination, optics, and clinical performance...
  13. ncbi Adaptive optics simulation of intraocular lenses with modified spherical aberration
    Patricia A Piers
    AMO Groningen, Groningen, P O Box 901, 9700 AX Groningen, The Netherlands
    Invest Ophthalmol Vis Sci 45:4601-10. 2004
    Adaptive optics systems can be used to investigate the potential visual benefit associated with correcting ocular wave-front aberration...
  14. ncbi Single-molecule optics
    Florian Kulzer
    Molecular Nano Optics and Spins MoNOS, Huygens Laboratory, University of Leiden, 2333 CA Leiden, The Netherlands
    Annu Rev Phys Chem 55:585-611. 2004
    ..The combination of microscopy with time- and frequency-resolved spectroscopy is opening a wide field of new and exciting applications to individual nano-objects...
  15. ncbi NLOPredict: visualization and data analysis software for nonlinear optics
    Andrew J Moad
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    J Comput Chem 28:1996-2002. 2007
    ..NLOPredict is available for most computer operating systems from http://sda.iu.edu/nlopredict/...
  16. ncbi Use of adaptive optics to determine the optimal ocular spherical aberration
    Patricia A Piers
    Department of Applied Research, AMO Groningen BV, Groningen, The Netherlands
    J Cataract Refract Surg 33:1721-6. 2007
    To explore the impact of spherical aberration (SA) on contrast sensitivity using an adaptive optics vision simulator to determine the optimal amount of SA to include in customized corrections of wavefront aberrations.
  17. ncbi Real-time probing of membrane transport in living microbial cells using single nanoparticle optics and living cell imaging
    Xiao Hong Nancy Xu
    Department of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia 23529, USA
    Biochemistry 43:10400-13. 2004
    ..3 pM) does not create significant toxicity for the cells, further validating that single Ag nanoparticles (1.3 pM) can be used as biocompatible nanoprobes for the study of membrane transport kinetics in living microbial cells...
  18. ncbi Evaluation of imaging performance of a taper optics CCD; FReLoN' camera designed for medical imaging
    Paola Coan
    European Synchrotron Radiation Facility, BP 220, 6 rue Horowitz, 38043 Grenoble Cedex 9, France
    J Synchrotron Radiat 13:260-70. 2006
    The purpose of this work was to assess the imaging performance of an indirect conversion detector (taper optics CCD; FReLoN' camera) in terms of the modulation transfer function (MTF), normalized noise power spectrum (NNPS) and detective ..
  19. ncbi Adaptive optics visual simulator
    Enrique J Fernandez
    Departamento de Fisica, Universidad de Murcia, Spain
    J Refract Surg 18:S634-8. 2002
    To develop a prototype instrument that uses adaptive optics to introduce virtually any desired aberration profile in a subject's eye...
  20. ncbi Monte Carlo simulation of 3D mapping of cardiac electrical activity with spinning slit confocal optics
    Seong min Hwang
    Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    Conf Proc IEEE Eng Med Biol Soc 1:1093-7. 2006
    ..The recent development of spinning slit confocal optics offers advantages of depth resolution as well as high-speed confocal imaging which are necessary for millisecond-..
  21. pmc Imaging in breast cancer: diffuse optics in breast cancer: detecting tumors in pre-menopausal women and monitoring neoadjuvant chemotherapy
    Bruce J Tromberg
    Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, CA, USA
    Breast Cancer Res 7:279-85. 2005
    ..This paper reviews the principles of diffuse optics and describes the development of broadband DOS for quantitatively measuring the optical and physiological ..
  22. ncbi Balance of corneal horizontal coma by internal optics in eyes with intraocular artificial lenses: evidence of a passive mechanism
    Susana Marcos
    Instituto de Optica Daza de Valdes, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Vision Res 48:70-9. 2008
    It is well known that the aberrations of the cornea are partially compensated by the aberrations of the internal optics of the eye (primarily the crystalline lens) in young subjects...
  23. ncbi Spectroscopy enhances the information content of optical mammography
    A E Cerussi
    University of California, Irvine, Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Rd, Irvine, California 92612, USA
    J Biomed Opt 7:60-71. 2002
    ..Multi-spectral measurements, compared to measurements restricted to one or two wavelengths, provide additional information that may be useful in managing breast disease...
  24. ncbi Adaptive optics in microscopy
    Martin J Booth
    Department of Engineering Science, University of Oxford, Parks Road, Oxford OX1 3PJ, UK
    Philos Trans A Math Phys Eng Sci 365:2829-43. 2007
    ..Adaptive optics technology has been employed in various systems to correct these aberrations and restore performance...
  25. ncbi Optical recording of fast neuronal membrane potential transients in acute mammalian brain slices by second-harmonic generation microscopy
    Daniel A Dombeck
    School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    J Neurophysiol 94:3628-36. 2005
    ....
  26. ncbi Photoreceptor inner segments in monkey and human retina: mitochondrial density, optics, and regional variation
    Q V Hoang
    Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 3107, USA
    Vis Neurosci 19:395-407. 2002
    ..The numerous cone mitochondria may enhance the waveguide properties of cones, particularly in the periphery...
  27. pmc Focal volume optics and experimental artifacts in confocal fluorescence correlation spectroscopy
    Samuel T Hess
    Department of Physics, Cornell University, Ithaca, New York 14853, USA
    Biophys J 83:2300-17. 2002
    ..result, the FCS autocorrelation will contain significant, systematic artifacts that are most severe with confocal optics when using a large detector aperture and aperture-limited illumination...
  28. ncbi High-resolution, in vivo retinal imaging using adaptive optics and its future role in ophthalmology
    Nathan Doble
    Iris AO Inc, 2680 Bancroft Way, Berkeley, CA, USA
    Expert Rev Med Devices 2:205-16. 2005
    ..The technique of adaptive optics not only corrects all of the static spatial modes but also measures and corrects any dynamic changes...
  29. ncbi The use of the Henyey-Greenstein phase function in Monte Carlo simulations in biomedical optics
    T Binzoni
    Département des Neurosciences Fondamentales, Centre Medical Universitaire, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Phys Med Biol 51:N313-22. 2006
    Monte Carlo (MC) simulations are often at the heart of the testing procedure in biomedical optics. One of the critical points in MC simulations is to define the new photon direction after each scattering event...
  30. ncbi Simulated annealing in ocular adaptive optics
    S Zommer
    Department of Physics, Technion Israel Institute of Technology, Haifa 32000, Israel
    Opt Lett 31:939-41. 2006
    We present what is to our knowledge a first hardware realization of a simulated annealing algorithm in an adaptive optics system designed to image the retina of the human eye...
  31. ncbi Focusing optics of a parallel beam CCD optical tomography apparatus for 3D radiation gel dosimetry
    Nikola Krstajic
    Department of Physics, University of Surrey, Guildford, Surrey, GU2 7XH, UK
    Phys Med Biol 51:2055-75. 2006
    ..This paper advances our previous work by introducing a new design of focusing optics, which take information from a suitably positioned focal plane and project an image onto the CCD...
  32. ncbi Optical single-channel recording: imaging Ca2+ flux through individual N-type voltage-gated channels expressed in Xenopus oocytes
    Angelo Demuro
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
    Cell Calcium 34:499-509. 2003
    ..Optical single-channel recording should be applicable to diverse voltage- and ligand-gated Ca2+-permeable channels, and has the potential for high-throughput functional analysis of single channels...
  33. ncbi Naive optics: understanding the geometry of mirror reflections
    Camilla J Croucher
    Department of Psychology, University of Liverpool, United Kingdom
    J Exp Psychol Hum Percept Perform 28:546-62. 2002
    ..Possible heuristics about mirror reflection that might explain the data are discussed. Naive optics is a promising venue to further knowledge of how observers understand basic laws of physics.
  34. ncbi Optical biosensor provides insights for bradykinin B(2) receptor signaling in A431 cells
    Ye Fang
    Biochemical Technologies, Science and Technology Division, Corning Incorporated, Sullivan Park, Corning, NY 14831, USA
    FEBS Lett 579:6365-74. 2005
    ..The roles of endocytosis and cytoskeleton modulation in B(2) signaling were also demonstrated...
  35. ncbi Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using a liquid crystal spatial light modulator
    Enrique J Fernandez
    Center for Biomedical Engineering and Physics, Vienna University of Medicine, Austria
    Vision Res 45:3432-44. 2005
    A liquid crystal programmable phase modulator (PPM) is used as correcting device in an adaptive optics system for three-dimensional ultrahigh-resolution optical coherence tomography (UHR OCT)...
  36. ncbi In vivo optical coherence tomography feasibility for bladder disease
    Elena V Zagaynova
    Nizhny Novgorod State Medical Academy and Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Russia
    J Urol 167:1492-6. 2002
    ..We identified characteristic optical coherence tomography patterns for nonproliferative and proliferative inflammation, and malignant alterations of the bladder...
  37. ncbi Optical single-channel recording by imaging Ca2+ flux through individual ion channels: theoretical considerations and limits to resolution
    Jianwei Shuai
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
    Cell Calcium 37:283-99. 2005
    ....
  38. ncbi Optical recording of action potentials with second-harmonic generation microscopy
    Daniel A Dombeck
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
    J Neurosci 24:999-1003. 2004
    ....
  39. pmc Whole-genome shotgun optical mapping of Rhodobacter sphaeroides strain 2.4.1 and its use for whole-genome shotgun sequence assembly
    Shiguo Zhou
    Laboratory for Molecular and Computational Genomics, University of Wisconsin Madison, UW Biotechnology Center, Madison, Wisconsin 53706, USA
    Genome Res 13:2142-51. 2003
    ..Our results show that such maps facilitated the closure of sequence gaps by the early detection of nascent sequence contigs during the course of the whole-genome shotgun sequencing process...
  40. ncbi Multitapered x-ray capillary optics for mammography
    Carla D Bradford
    Department of Medical Physics, Rhode Island Hospital, Providence 02903, USA
    Med Phys 29:1097-108. 2002
    ..The long term goal of this project is to improve the x-ray mammographic imaging system using capillary optics. A post-patient capillary optic lens has the potential to increase spatial resolution and eliminate the detection ..
  41. ncbi Three-dimensional nanometry of vesicle transport in living cells using dual-focus imaging optics
    Tomonobu M Watanabe
    Biomedical and Engineering Research Organization, Tohoku University, Sendai, Miyagi 980 8579, Japan
    Biochem Biophys Res Commun 359:1-7. 2007
    Dual-focus imaging optics for three-dimensional tracking of individual quantum dots has been developed to study the molecular mechanisms of motor proteins in cells...
  42. ncbi Correcting highly aberrated eyes using large-stroke adaptive optics
    Ramkumar Sabesan
    Institute of Optics University of Rochester, Rochester, NY 14627, USA
    J Refract Surg 23:947-52. 2007
    ..To investigate the optical performance of a large-stroke deformable mirror in correcting large aberrations in highly aberrated eyes...
  43. ncbi Single-molecule detection sensitivity using planar integrated optics on a chip
    Dongliang Yin
    School of Engineering, University of California Santa Cruz 95064, USA
    Opt Lett 31:2136-8. 2006
    ..Integrated silicon photonics combined with single-molecule detection in solution create a compact, robust, and sensitive platform that has applications in numerous fields ranging from atomic physics to the life sciences...
  44. ncbi Bulk optical properties of healthy female breast tissue
    T Durduran
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia 19104, USA
    Phys Med Biol 47:2847-61. 2002
    ..The new information on healthy breast tissue provides insight about the potential contrasts available for diffuse optical tomography of breast tumours...
  45. ncbi Quantum cascade semiconductor infrared and far-infrared lasers: from trace gas sensing to non-linear optics
    Geoffrey Duxbury
    Department of Physics, University of Strathclyde, John Anderson Building, 107 Rottenrow, Glasgow, UK G4 0NG
    Chem Soc Rev 34:921-34. 2005
    ..In this tutorial review we survey some of the applications of these new lasers, which range from trace gas detection for atmospheric or medical purposes to sub-Doppler and time dependent non-linear spectroscopy...
  46. ncbi Realistic three-dimensional epithelial tissue phantoms for biomedical optics
    Konstantin Sokolov
    University of Texas Austin, Biomedical Engineering Program, Austin, Texas 78712, USA
    J Biomed Opt 7:148-56. 2002
    ..We also demonstrate that the proposed phantoms provide an opportunity to study changes in optical properties of different tissue components as a result of their interactions with each other or exogenous factors...
  47. ncbi Pupil shapes and lens optics in the eyes of terrestrial vertebrates
    Tim Malmström
    Department of Cell and Organism Biology, Lund University, Zoology Building, Helgonavagen 3, 22362 Lund, Sweden
    J Exp Biol 209:18-25. 2006
    ..Multifocal optical systems in nocturnal prosimians suggest that those animals have colour vision despite being described as cone monochromats...
  48. ncbi Optics of wide-angle panoramic viewing system-assisted vitreous surgery
    Kakarla V Chalam
    Department of Ophthalmology, 580 W 8th Street, University of Florida College of Medicine, Jacksonville, FL 32209, USA
    Surv Ophthalmol 49:437-45. 2004
    The purpose of the article is to describe the optics of the contact wide-angle lens system with stereo-reinverter for vitreous surgery...
  49. pmc Color naming, lens aging, and grue: what the optics of the aging eye can teach us about color language
    Joseph L Hardy
    Department of Ophthalmology, University of California, 4860 Y St, Suite 2400, Sacramento, CA 95817, USA
    Psychol Sci 16:321-7. 2005
    ..Color naming for stimuli that were nominally green, blue-green, or blue was virtually identical for older and younger observers who viewed the same (unfiltered) stimuli. Our results are inconsistent with the lens-brunescence hypothesis...
  50. ncbi Exploration of the optimisation algorithms used in the implementation of adaptive optics in confocal and multiphoton microscopy
    Amanda J Wright
    Institute of Photonics, Wolfson Centre, Glasgow G4 0NW, United Kingdom
    Microsc Res Tech 67:36-44. 2005
    ..The conventional approach to adaptive optics, commonly used in astronomy, is to utilise a wavefront sensor to determine the required mirror shape...
  51. ncbi Biomimetic interfaces for high-performance optics in the deep-UV light range
    Theobald Lohmüller
    Max Planck Institute for Metals Research, Department of New Materials and Biosystems and University of Heidelberg, Department of Biophysical Chemistry, Heisenbergstrasse 3, D 70569 Stuttgart, Germany
    Nano Lett 8:1429-33. 2008
    ..The far reaching optical performance of these structures is demonstrated by reflection and transmission measurements at oblique angles of incidence over a broad spectral region ranging from deep-ultraviolet to infrared light...
  52. pmc Stokes vector analysis of adaptive optics images of the retina
    Hongxin Song
    School of Optometry, Indiana University, 800 East Atwater Avenue, Bloomington, Indiana 47405, USA
    Opt Lett 33:137-9. 2008
    ....
  53. ncbi Microchemical element imaging of yeast and human cells using synchrotron X-ray microprobe with Kirkpatrick-Baez optics
    Richard Ortega
    Chimie Nucléaire Analytique et Bioenvironnementale, CNRS Université de Bordeaux 1, BP 120 33175 Gradignan cedex, France
    Anal Chem 76:309-14. 2004
    ..A focusing system based on Kirkpatrick-Baez design optics mounted on a synchrotron radiation scanning X-ray microscope has been developed at the ESRF and was used for trace ..
  54. ncbi Cellular functions of cholesterol probed with optical biosensors
    Ye Fang
    Biochemical Technologies, Science and Technology Division, Corning Incorporated, Sullivan Park, Corning, NY 14831, USA
    Biochim Biophys Acta 1763:254-61. 2006
    ....
  55. ncbi [Aspheric optics: physical fundamentals]
    M Mrochen
    IROC AG, Institut für Refraktive und Ophthalmo Chirurgie, Stockerstrasse 37, 8002 Zurich, Schweiz
    Ophthalmologe 105:224-33. 2008
    ..surgery, one finds numerous concepts on how to improve the optical quality of the human eye through aspheric optics. Aspheric optics consists of optical surfaces in which at least one surface (for example, the corneal surface) ..
  56. ncbi Deconvolution of adaptive optics retinal images
    Julian C Christou
    Center for Adaptive Optics, University of California, Santa Cruz, California 95064, USA
    J Opt Soc Am A Opt Image Sci Vis 21:1393-401. 2004
    ..Qualitatively, deconvolution improves the contrast of the adaptive optics images...
  57. ncbi Optical slicing of human retinal tissue in vivo with the adaptive optics scanning laser ophthalmoscope
    Fernando Romero-Borja
    College of Optometry, University of Houston, 4800 Calhoun Road, Houston, Texas 77204 2020, USA
    Appl Opt 44:4032-40. 2005
    ..imaging results in human retinal tissue in vivo that allowed us to determine the axial resolution of the adaptive optics scanning laser ophthalmoscope (AOSLO)...
  58. ncbi Study on the effects of monochromatic aberrations in the accommodation response by using adaptive optics
    Enrique J Fernandez
    Laboratorio de Optica, Departamento de Fisica, Universidad de Murcia, Campus de Espinardo Edificio C, 30071 Murcia, Spain
    J Opt Soc Am A Opt Image Sci Vis 22:1732-8. 2005
    The effect of asymmetric monochromatic aberrations in the accommodation response was studied by using an adaptive optics (AO) system. This approach permits the precise modification of ocular aberrations during accommodation...
  59. ncbi Imperfect optics may be the eye's defence against chromatic blur
    James S McLellan
    Schepens Eye Research Institute, 20 Staniford Street, Boston, Massachusetts 02114, USA
    Nature 417:174-6. 2002
    The optics of the eye cause different wavelengths of light to be differentially focused at the retina. This phenomenon is due to longitudinal chromatic aberration, a wavelength-dependent change in refractive power...
  60. ncbi Parallel confocal detection of single biomolecules using diffractive optics and integrated detector units
    H Blom
    Department of Medical Biophysics, Karolinska Intitutet, Stockholm
    Curr Pharm Biotechnol 5:231-41. 2004
    ....
  61. ncbi High-energy x-ray microbeam with total-reflection mirror optics
    Yoshio Suzuki
    Japan Synchrotron Radiation Research Institute, SPring 8 1 1 1 Koto, Sayo, Hyogo 679 5198, Japan
    Rev Sci Instrum 78:053713. 2007
    Total-reflection mirror optics for high-energy x-ray microfocusing have been developed, and tested in the energy range of 30-100 keV at beamline 20XU of Synchrotron Radiation Facility SPring-8...
  62. ncbi Optoacoustic real-time dosimetry for selective retina treatment
    Georg Schuele
    Medical Laser Center, Lubeck, Germany
    J Biomed Opt 10:064022. 2005
    ..It detects the ophthalmoscopically invisible laser-induced damage of RPE cells and overcomes practical limitations of SRT for use in private practice...
  63. ncbi Fringe-free, background-free, collinear third-harmonic generation frequency-resolved optical gating measurements for multiphoton microscopy
    Rebecca Chadwick
    Colorado School of Mines, Golden, Colorado 80401, USA
    Opt Lett 31:3366-8. 2006
    ..A background-free, fringe-free form of frequency-resolved optical gating using the third-harmonic signal generated from a glass coverslip is used to characterize 100 fs pulses at the focus of a 0.65 NA objective...
  64. ncbi Compact detector for proteins based on two-photon excitation of native fluorescence
    Uchenna P Paul
    Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA
    Anal Chem 77:3690-3. 2005
    ..Detection limits for phenylalanine, tyrosine, and tryptophan were 62 microM, 2.0 microM, and 470 nM, respectively, in a volume of 3 fL. The detection limit for a test protein, bovine serum albumin, was 130 nM...
  65. ncbi Counter-propagating optical trapping system for size and refractive index measurement of microparticles
    Richard A Flynn
    Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA
    Biosens Bioelectron 21:1029-36. 2006
    ..A ray-optics model is used to explore the physical operation of the COTM system, predict system performance and aid system ..
  66. ncbi Discontinuous free-form lens design for prescribed irradiance
    Lin Wang
    Semiconductor Lighting Laboratory, Graduate School of Shenzen, Tsinghua University, Shenzhen, China
    Appl Opt 46:3716-23. 2007
    ..From these mapping and normal control methods, a fast and efficient algorithm has been developed for several prescribed irradiance problems with simple nonrotational shape of the illuminated region...
  67. ncbi Optical biosensor with dispersion compensation
    W Zong
    Vir Biosensor, Vir A S, Kuldyssen 10, DK 2630 Taastrup, Denmark
    Opt Lett 30:1138-40. 2005
    ..The concept can readily be employed in other types of sensor measuring refractive-index changes...
  68. ncbi Optical detection of honeybees by use of wing-beat modulation of scattered laser light for locating explosives and land mines
    Kevin S Repasky
    Electrical and Computer Engineering Department, Cobleigh 610, Montana State University, Bozeman, Montana 59717, USA
    Appl Opt 45:1839-43. 2006
    ..The optical detection of honeybees has application in the biological detection of land mines and explosives, as was recently demonstrated...
  69. ncbi Position of the prism in a dispersion-compensated acousto-optic deflector for multiphoton imaging
    Kun Bi
    Wuhan National Laboratory for Opto electronics, Key Laboratory of Biomedical Photonics of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430074, China
    Appl Opt 45:8560-5. 2006
    ..On the basis of these experiments, the prism-AOD configuration is concluded to be more advantageous for the purpose of simultaneous compensation for the spatial and temporal dispersion...
  70. ncbi Grating-less, fiber-based oscillator that generates 25 nJ pulses at 80 MHz, compressible to 150 fs
    J An
    Department of Physics, Pohang University of Science and Technology, Pohang, South Korea, 790 784
    Opt Lett 32:2010-2. 2007
    ..This design, which we believe to be the first of its kind, produces 25 nJ pulses at 80 MHz with the pulses compressible to 150 fs. The pulses appear to be self-similar and initial data imply that their energy is further scalable...
  71. ncbi Random-dot pattern design of a light guide in an edge-lit backlight: integration of optical design and dot generation scheme by the molecular-dynamics method
    Jee Gong Chang
    National Center for High Performance Computing, Taiwan
    J Opt Soc Am A Opt Image Sci Vis 24:839-49. 2007
    ....
  72. ncbi Phase and polarization control as a route to plasmonic nanodevices
    Maxim Sukharev
    Department of Chemistry, Northwestern University, Evanston, Illinois 60208 3113, USA
    Nano Lett 6:715-9. 2006
    ..Implications to research fields such as single molecule spectroscopy, spatially confined chemistry, optical logic, and nanoscale sensing are envisioned...
  73. pmc Numerical study of wavelength-swept semiconductor ring lasers: the role of refractive-index nonlinearities in semiconductor optical amplifiers and implications for biomedical imaging applications
    A Bilenca
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Opt Lett 31:760-2. 2006
    ....
  74. ncbi Sub-diffraction-limited multilayer coatings for the 0.3 numerical aperture micro-exposure tool for extreme ultraviolet lithography
    Regina Soufli
    Lawrence Livermore National Laboratory, Livermore, California 94550, USA
    Appl Opt 46:3736-46. 2007
    ..07 waves rms). This work is an experimental demonstration of sub-diffraction- limited multilayer coatings for high-NA EUV imaging systems, which resulted in the highest resolution microfield EUV images to date...
  75. ncbi Controlled photon transfer between two individual nanoemitters via shared high-Q modes of a microsphere resonator
    S Götzinger
    Nano Optics, Humboldt University, Hausvogteiplatz 5 7, D 10117 Berlin, Germany
    Nano Lett 6:1151-4. 2006
    ..We estimate the photon transfer efficiency to be about 6 orders of magnitude higher than that via free-space propagation at comparable separations...
  76. ncbi Focal-plane imaging of crossed beams in nonlinear optics experiments
    Daniel Bivolaru
    Advanced Sensing and Optical Measurement Branch, NASA Langley Research Center, 18 Langley Boulevard, Hampton, VA 23681, USA
    Rev Sci Instrum 78:056102. 2007
    ..We find that this imaging diagnostic significantly reduces beam alignment time and loss of CARS-IRS signals due to inadvertent misalignments...
  77. ncbi Optical images of dose distributions in Gel-Fricke: dosimetric performances of the gel
    A M Luciani
    Department of Technology and Health and INFN Sanità Group, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy
    Radiat Prot Dosimetry 122:455-6. 2006
    ..015 Gy. The comparison with alanine dosemeters in the dose range 7-10 Gy showed agreement within a few per cent and the same agreement was observed for the comparison with TLD in the range 1-3 Gy...
  78. ncbi A simplified measurement procedure and portable electronic photometer for disposable sensors based on ionophore-chromoionophore chemistry for potassium determination
    A Palma
    Department of Electronics and Computer Technology, Campus Fuentenueva, Faculty of Sciences, University of Granada, 18071 Granada, Spain
    Anal Bioanal Chem 386:1215-24. 2006
    ..Given the compact size, low weight, rapid response and low energy requirement of the electronic photometer developed here, this measurement system is suitable for potassium determination in the field...
  79. ncbi Mode propagation in optical nanowaveguides with dielectric cores and surrounding metal layers
    Anatoly S Lapchuk
    Central Research and Development Institute, Samsung Electro Mechanics Company, Ltd, Suwon 442 743, South Korea
    Appl Opt 44:7522-31. 2005
    ..e., in which all dielectric surfaces are covered with metal films, the cross-sectional shape of the waveguide should be stretched along one side to produce propagation conditions for the fundamental mode...
  80. ncbi Pulsed acousto-optic imaging in dynamic scattering media with heterodyne parallel speckle detection
    M Atlan
    Laboratoire d Optique, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris, France
    Opt Lett 30:1360-2. 2005
    ..Test experiments confirm the suitability of this method for performing tomographies inside various types of optically scattering media, including liquids...
  81. pmc Designing the optical interface of a transcutaneous optical telemetry link
    D Michael Ackermann
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    IEEE Trans Biomed Eng 55:1365-73. 2008
    ..include the thickness of the skin through which the light is transmitted, the size of the integration area of the optics, the degree of transmitter-receiver misalignment, the efficiency of the optics system, and the emitter power...
  82. ncbi Terahertz near-field imaging
    John F Federici
    Department of Physics, New Jersey Institute of Technology, Newark, NJ 07102, USA
    Phys Med Biol 47:3727-34. 2002
    ..5 THz. We present a study of the performance of the near-field probes in the collection mode configuration and discuss some image properties...
  83. ncbi All-optoelectronic continuous wave THz imaging for biomedical applications
    Karsten J Siebert
    Physikalisches Institut der J W Goethe Universität, Robert Mayer Street 2 4, D 60054 Frankfurt, Germany
    Phys Med Biol 47:3743-8. 2002
    ..For a specific histological sample, an analysis of image noise is discussed...
  84. ncbi Terahertz pulse transmission in plastic photonic crystal fibres
    H Park
    Department of Electrical and Computer Engineering, Pohang University of Science and Technology, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Korea
    Phys Med Biol 47:3765-9. 2002
    ..1-3 THz. Such PPCFs have the promise of low loss, mechanically flexible interconnect channels for compact THz devices and systems...
  85. ncbi New application of terahertz time-domain spectrometry (THz-TDS) to the phonon-polariton observation on ferroelectric crystals
    Seizi Nishizawa
    Cooperative Research Center, Shinshu University, Nagano 380 8553, Japan
    Phys Med Biol 47:3771-6. 2002
    ..The complex dielectric constants are well reproduced by the phonon-polariton dispersion relation based on the Kurosawa formula. The instrument details and phonon-polariton dispersion results are described...
  86. ncbi Nanoscale microcavity sensor for single particle detection
    Mindy R Lee
    The Institute of Optics, University of Rochester, Rochester, New York 14627, USA
    Opt Lett 32:3284-6. 2007
    ..With an active sensing volume of approximately 0.15 microm(3), the device is capable of detecting approximately 1 fg of matter. Its performance is tested with latex spheres with sizes that fall in the size range of a variety of viruses...
  87. ncbi Design of an ultralight and compact projection lens
    Hong Hua
    Beckman Institute, University of Illinois Urbana Champaign, Urbana, Illinois 61801, USA
    Appl Opt 42:97-107. 2003
    ..The key contribution here lies in the conception, optimization, and assessment of the projection optics. Thus a brief review of the HMPD technology and related research is followed by a detail discussion of the ..
  88. ncbi Light-scattering instrument to detect thromboemboli in blood
    Kenneth Solen
    Brigham Young University, Department of Chemical Engineering, Provo, Utah 84602, USA
    J Biomed Opt 8:70-9. 2003
    ..Through this work, the LSMD evolved as a sensitive and an economical research tool for the study of thromboembolic phenomena...
  89. ncbi Changes of optical properties of retroreflector installed in LHD
    T Akiyama
    National Institute for Fusion Science, 322 6 Oroshi cho, Toki shi, Gifu 509 5292, Japan
    Rev Sci Instrum 78:103501. 2007
    ..The parallelism of the reflected beam to an incident one also deteriorated. The changes in the polarization angle and in the ellipticity of reflected light polarization were not observed from the visible to the far infrared range...
  90. ncbi An electronic read-out circuit for time-domain terahertz imaging with photoconductive antennas
    M Herrmann
    Communications Research Laboratory, Kansai Advanced Research Center, Iwaoka 588 2, Nishi ku, Kobe 651 2492, Japan
    Phys Med Biol 47:3711-8. 2002
    ..The performance was verified in terahertz time-domain spectroscopy based on an amplified femtosecond laser and found to be better than that of a commercial lock-in amplifier...
  91. ncbi Optimization of photoconducting receivers for THz spectroscopy
    S R Andrews
    Department of Physics, University of Bath, Bath BA2 7AY, UK
    Phys Med Biol 47:3705-10. 2002
    ..The dynamic range achieved with comparable silicon receivers is a factor of 2 smaller...
  92. ncbi Middle infrared, quantum cascade laser optoelectronic absorption system for monitoring glucose in serum
    W Blake Martin
    University of Alabama at Birmingham, Department of Biomedical Engineering, 1075 13th St S, Suite 370, AL 35294, USA
    Appl Spectrosc 59:881-4. 2005
    ..The average predictive standard errors of the mean (SEM) were 32.5 and 24.7 mg/dL, respectively, for each method. Quantum cascade lasers could be used to develop middle infrared devices for uses beyond the confines of the laboratory...
  93. ncbi Integrated Raman- and angular-scattering microscopy
    Zachary J Smith
    The Institute of Optics, University of Rochester, Rochester, NY 14627, USA
    Opt Lett 33:714-6. 2008
    ..The microscope system exhibits 3 nm precision in predicting sphere diameters, while simultaneously yielding high-quality Raman signals. Applications to single cell analysis are envisioned...
  94. ncbi Design rules for phase-matched terahertz surface electromagnetic wave generation by optical rectification in a nonlinear planar waveguide
    Roman R Musin
    Department of Physics, International Laser Center, M V Lomonosov Moscow State University, Vorob evy Gory, Moscow, Russia 119992
    Appl Opt 47:489-94. 2008
    ....
  95. ncbi ZnO tetrapods designed as multiterminal sensors to distinguish false responses and increase sensitivity
    Zengxing Zhang
    Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China
    Nano Lett 8:652-5. 2008
    ..This should be helpful for weak signal measurements of nanodevices...
  96. ncbi Ray-optic analysis of the (bio)sensing ability of ring-cladding hollow waveguides
    A M Zheltikov
    Department of Physics, International Laser Center, MV Lomonosov Moscow State University, Vorob evy Gory, Moscow, Russia
    Appl Opt 47:474-9. 2008
    ....
  97. ncbi Laser-induced fluorescence detection on multichannel electrophoretic microchips using microprocessor-embedded acousto-optic laser beam scanning
    Zhili Huang
    Department of Chemistry, University of Virginia, Charlottesville 22901, USA
    IEEE Trans Biomed Eng 49:859-66. 2002
    ....
  98. ncbi Characterization of three-color CARS in a two-pulse broadband CARS spectrum
    Young Jong Lee
    Polymers Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA
    Opt Lett 32:3370-2. 2007
    ..Official contribution of the National Institute of Standards and Technology; not subject to copyright in the United States...
  99. ncbi Time-gated Fourier-domain optical coherence tomography
    Matthew S Muller
    Department of Physics, Engineering Physics and Astronomy, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Opt Lett 32:3336-8. 2007
    ..This technique has the additional advantage that imaging is done in the infrared (approximately 1280 nm) but is detected in the visible(approximately 504 nm)...
  100. ncbi Few-cycle THz generation for imaging and tomography applications
    J Darmo
    Institute for Solid State Electronics, Technical University Vienna, Floragasse 7, A 1040 Vienna, Austria
    Phys Med Biol 47:3691-7. 2002
    ..The methods for generating few-cycle THz radiation from semiconductors without external applied fields are reviewed. Their spectral characteristics, efficiency and prospects for imaging and tomography at terahertz frequencies are discussed...
  101. ncbi Self-mixing in a diode laser as a method for cardiovascular diagnostics
    Kalju Meigas
    Tallinn Technical University, Biomedical Engineering Centre, Ehitajate tee 5, 19086 Tallinn, Estonia
    J Biomed Opt 8:152-60. 2003
    ....

Research Grants77

  1. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  2. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
    ..The proposed analyzer is based on new, powerful, proprietary, monochromatic doubly curved crystal (DCC) X-ray optics technology that greatly increases the efficiency and sensitivity for elemental analysis...
  3. Wireless At-Risk Infant Monitoring System
    JASON HOLMSTEDT; Fiscal Year: 2012
    ..To reduce infant mortality and provide an improved alternative to the existing newborn care, Physical Optics Corporation (POC) proposes to develop a Wireless At-Risk Infant Monitoring (WARM) system based on flexible ..
  4. Dynamics of Kinesins, Dyneins, and Myosins
    Paul R Selvin; Fiscal Year: 2010
    ..as a function of insertion length of the cargo-binding domain of myosin VI (with L. Sweeney, UPenn.). d) Technological developments: Optics/microscopy needs to be achieved to fulfill the above goals.
  5. Evaluation of obstructive sleep apnea with long range 3D endoscopic FDOCT
    Jun Zhang; Fiscal Year: 2013
    ..biomedical and clinical research that will complement the candidate's existing expertise in engineering and optics. A team of mentors who are recognized experts and leaders in airway physiology, sleep medicine and biomedical ..
  6. Real-Time Optical Diagnosis of Inflammatory Bowel Disease using SFDI
    Sylvain Gioux; Fiscal Year: 2013
    ..about the clinical work environment, and in order to expand his expertise, needs advanced training in biomedical optics theory...
  7. QUANTITATIVE ANALYSIS OF AGING RETINA
    Christine A Curcio; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Because the retina is so readily visible through the eye's optics, clinical imaging is now an essential component of staging and monitoring patients involved in clinical trials for ..
  8. An Innovative Endoscopic Instrument with Full-Field Viewing and Intelligent Imagi
    STEVEN YI; Fiscal Year: 2010
    ..Built on our patent pending 360 degree imaging optics, with unique image unwarping and robust panoramic stabilization techniques, our proposed system will have the ..
  9. CRCNS: Gamma Rhythms and Cell Assemblies
    Nancy Kopell; Fiscal Year: 2013
    ..combination of mathematical modeling with application of a set of emerging techniques involving molecular biology, optics, and electrophysiology to study the cell-type specific and circuitry properties of networks that produce gamma ..
  10. Structural and Functional Changes in Myopia and Susceptibility to Glaucoma
    Lisa Ostrin; Fiscal Year: 2013
    ..Lisa Ostrin graduated from the University of Houston College of Optometry with an OD and PhD in physiological optics, where she studied accommodative physiology...
  11. Mechanics of Inner Ear Hair Bundles
    KIRIAKI DOMENICA KARAVITAKI; Fiscal Year: 2012
    ..The motion will be observed using a two photon microscope and DIC optics and quantified by applying Fourier analysis on the captured images...
  12. NIH Director's Pioneer Award
    Karl Deisseroth; Fiscal Year: 2009
    ..abstract_text> ..
  13. Light-Alarming Personal Noise Dosimeter System
    ALEXANDER MILOVANOV; Fiscal Year: 2013
    ..To address this problem, Physical Optics Corporation (POC) proposes to develop a novel Light-Alarming personal Noise Dosimeter (LAND) system that ..
  14. Systems microscopy analysis of tumor cell motility in microenvironment context
    Bojana Gligorijevic; Fiscal Year: 2013
    ..Gligorijevic has become an expert in optics and live cell microscopy over the course of her graduate training at Georgetown University and developed several ..
  15. Phase-contrast enhanced X-ray imaging system for small joints of hand
    Thomas J Beck; Fiscal Year: 2010
    ..In addition, there are efforts at the JHU Department of Physics and elsewhere to develop phase-contrast optics for higher X-ray energy...
  16. Aspheric SDOCT Imaging System for Dry Eye and Cornea Diagnostics
    ERIC L BUCKLAND; Fiscal Year: 2012
    ..The notable design objective is to provide optics suited to imaging curved surfaces with a wide field of view...
  17. Phase-contrast X-ray imaging system for large joints
    Dan Stutman; Fiscal Year: 2012
    ..R21 research will prepare the grounds for the clinical prototype development, by fabricating and testing mirror optics, by demonstrating the DPC system for high energy, and by studying and optimizing DPC line scan imaging and ..
  18. Easy-to-Use, Low-Cost, Handheld Retinal Camera for Screening for Diabetic Retinop
    RANDAL CHINNOCK; Fiscal Year: 2009
    ..This proposal leverages the latest developments in optics, digital imagers, and image processing techniques to produce a novel, inexpensive device suitable for screening ..
  19. Microinjection Station for Utah Transgenic and Gene Targeting Mouse Core
    SUSAN JENIFER TAMOWSKI; Fiscal Year: 2010
    ..100% germline gene-targeted mice can also result from injecting ES cells into 8-cell stage embryos. Excellent optics and micromanipulators are essential to these procedures...
  20. New Optics for Trace Level Detection of Toxins in Environmental and Biological Sa
    ZEWU CHEN; Fiscal Year: 2010
    ..In the proposed project, XOS will develop X-ray optics that can be integrated into commercial XRF systems...
  21. Multiphoton Fluorescence Lifetime Imaging of Solid Tumors Invivo
    V Krishnan Ramanujan; Fiscal Year: 2010
    ..tumors in vivo;Systematic characterization of light propagation in tissues and the combined effects of system optics and tissue properties on measured lifetimes will be evaluated and utilized in the design and fabrication of the in ..
  22. Single Cross-Bridge Kinetics in Transgenic Mouse Hearts Expressing FHC Mutations
    Danuta Szczesna-Cordary; Fiscal Year: 2012
    ..We believe that integration of molecular biology approaches with high resolution optics and nano-fluorescence spectroscopy will enable us to successfully answer important questions regarding the ..
  23. Automated Macrodissection Device
    Nils B Adey; Fiscal Year: 2012
    ..The new instrument will be a computer controlled system that will includes x.y.z positioning, integrated optics, and multiple choices of specialized tissue removal and recovery tips...
  24. Low Cost Multi-pathogen Laser Diagnostic for HIV and AIDS Co-Infections
    CHRISTOPHER JOHN MYATT; Fiscal Year: 2011
    ..g., DVD player lasers) and optics (consumer and cell phone cameras)...
  25. Advances in Optics for Biotechnology, Medicine and Surgery
    James W Tunnell; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This proposal is requesting funds to support "Advances in Optics for Biotechnology, Medicine and Surgery", an interdisciplinary conference, optimally sized for cross-fertilization (~120 attendee), ..
  26. Real-Time Flap Viability Monitoring during Facial Transplantation using SFDI
    BERNARD TRAVIS LEE; Fiscal Year: 2013
    ..Dr. Bruce Tromberg at UC Irvine is an international leader in biomedical optics whose laboratory first developed the SFDI technique. Dr...
  27. High Performance Multimodal Adaptive Optics Retinal Imaging
    R Daniel Ferguson; Fiscal Year: 2011
    ..PSI) has successfully completed a Phase I program to develop a multimodal adaptive optics (AO) retinal imager for diagnosis of retinal diseases, including glaucoma, diabetic retinopathy (DR), age-related ..
  28. A shared macromolecular X-ray diffraction system in Rochester
    Joseph E Wedekind; Fiscal Year: 2010
    ..the planning stages, our tests indicated that the Bruker AXS I?S microfocus sealed tube X- ray source, integrated optics, APEX II CCD detector, Oxford 700 cold stream and motorized goniometer head (for rapid sample centering) mounted ..
  29. Instrument for Single Molecule Sequencing of Alzheimer's-Relevant Genomic Oxidati
    David E Wolf; Fiscal Year: 2012
    ..b>Optics will be optimized, and the equipment will be evaluated for the capability to achieve single-base resolution in ..
  30. Plasmon-Controlled Fluorescence and Cardiac Markers
    Joseph R Lakowicz; Fiscal Year: 2013
    ..Towards this direction our approach combines the emerging sciences of plasmonics and nano-optics to increase the sensitivity of fluorescence for clinical testing...
  31. MicroRNA pathway in mechanisms of nanoparticles neurotoxicity
    Alexander K Murashov; Fiscal Year: 2010
    ..structures have novel properties that make them useful in many applications in nanotechnology, electronics, optics, as well as in medicine. Their final usage, however, may be limited by their potential toxicity...
  32. Synapt G2-S System with HXMS Automation
    Elizabeth A Komives; Fiscal Year: 2013
    ..system is fully integrated with the qTOF mass spectrometer which combines dual-T-wave, off-axis ion transfer optics to transfer ions from the ion source to the quadrupole MS analyzer with the highest possible efficiency...
  33. Lab-on-a-chip Flow Cytometer Using COlor-Space-Time (COST) Coding Method
    JOSE MANUEL MORACHIS; Fiscal Year: 2011
    ..In today's flow cytometer design, each fluorescent color requires a dedicated PMT and optics;and the cost, complexity, and risk of failure grow with the number of detection parameters...
  34. Adaptive Optics Instrumentation for Advanced Ophthalmic Imaging
    David R Williams; Fiscal Year: 2012
    This Bioengineering Research Partnership is a consortium of 6 laboratories that are building adaptive optics scanning laser ophthalmoscopes (AOSLOs) and applying them to microscopic examination of the living normal and diseased retina...
  35. Ear Canal Optical Coherent Tomography System
    PAUL SHNITSER; Fiscal Year: 2010
    ..Physical Optics Corporation proposes development of a new Ear Canal Optical Coherent Tomography (ECOCT) system to obtain the shape ..
  36. High-resolution imaging of the normal and diseased retina
    Jason Porter; Fiscal Year: 2013
    ..in laminar pore geometry over the time course of experimental glaucoma in macaque monkeys with a confocal adaptive optics scanning laser ophthalmoscope (AOSLO)...
  37. The role of PPAR{gamma} ligands in corneal wound healing and optics
    Krystel R Huxlin; Fiscal Year: 2013
    ..We predict that PPAR3 ligands will be associated with lower cell death, faster wound healing, less haze and lower induction of higher-order optical aberrations than use of anti-TGF2 antibodies, steroids or Mitomycin C post-operatively. ..
  38. MULTIPHOTON CONFOCAL MICROSCOPE
    Liza A Pon; Fiscal Year: 2010
    ..Finally, the system is cost-effective, as we can take ad- vantage of existing accessories (e.g. lenses, DIC optics, and environmental control for live-cell imaging)...
  39. Non-contact Diffuse Optical Assessment of Pressure Ulcer and Therapy
    Guoqiang Yu; Fiscal Year: 2013
    ..A new advanced technology, near- infrared diffuse optics, can noninvasively monitor blood flow and oxygenation in deep tissues (up to several centimeters) with fiber-optic ..
  40. Nanotechnology for Minimally Invasive Cancer Detection and Resection
    Aaron M Mohs; Fiscal Year: 2011
    ..In addition, the collaborative training will be supplemented by formal coursework at Emory and Georgia Tech in optics and instrumentation...
  41. Development of Spectroscopic Biomarkers of Bone Quality in Metastatic Disease
    Xiaohong Bi; Fiscal Year: 2013
    ..objectives 1) to enrich her knowledge in cancer biology, 2) to expand her specialty in the field of biomedical optics, 3) to pursue a serious research project from which she will gain experience in biomedical research and obtain ..
  42. Ophthalmic Imaging Using Adaptive Optics and OCT
    John S Werner; Fiscal Year: 2012
    ..Partners at four institutions will contribute to instrumentation that combines adaptive optics (AO), providing high lateral resolution, with optical coherence tomography (OCT), providing high axial resolution...
  43. Multimodality Imaging of GI Cancers for Diagnosis and Directed Therapy
    Christopher H Contag; Fiscal Year: 2013
    ..The overarching aim of this program is develop a consensus process and methodology based on optics and ultrasound to optimize detection of early molecular markers of disease by examining molecular markers in the ..
  44. Completely Digitizing the Custom-Fit Hearing Aid Shell Manufacturing Process
    STEVEN YI; Fiscal Year: 2010
    ..3D Modeling Process that Totally Eliminates Physical Impressions; " Innovative Miniature 3D and 3600 Imaging Optics Never Reported Before; " A Unique Multi-Sensor Fusion Based Hardware Platform;and " Innovative IMU Augmented 3D ..
  45. In-Incubator Live Cell Fluorescence/DIC Time Lapse Imaging System
    Martin F Schneider; Fiscal Year: 2010
    ..The microscope uses DIC or epi-fluorescence optics to acquire images, movies, z- stacks, etc...
  46. Photonic Magnetometer-based Biomagnetic Imaging System
    John Matthews; Fiscal Year: 2010
    ..multichannel magnetic imaging system capable of operating in an unshielded clinical environment, Physical Optics Corporation (POC) proposes to develop a Photonic Magnetometer-based Biomagnetic Imaging (PMBI) system...
  47. Ear Canal Optical Coherence Tomography System
    PAUL SHNITSER; Fiscal Year: 2013
    ..Physical Optics Corporation (POC) proposes the development of a new Ear Canal Optical Coherent Tomography (ECOCT) system to obtain ..
  48. Targeted Multi-Spectral Dual Axes Confocal Imaging of In Vivo Molecular Expressio
    Thomas D Wang; Fiscal Year: 2013
    ..Post-objective scanning provides a large field-of-view as well as scalability and miniaturization of the optics, and a replicated parabolic mirror directs collimated, multi-spectral beams to a common focus...
  49. Diffuse Optics for Acute Stroke Management
    Arjun G Yodh; Fiscal Year: 2012
    ..in cerebrovascular physiology and human stroke with biophysical scientists &engineers with expertise in optics, electronics, mathematics and computation...
  50. Lab-on-a-chip Flow Cytometer Using COlor-Space-Time (COST) Coding Method
    JOSE MANUEL MORACHIS; Fiscal Year: 2012
    ..In today's flow cytometer design, each fluorescent color requires a dedicated PMT and optics;and the cost, complexity, and risk of failure grow with the number of detection parameters...
  51. Multi-Spectral Parallel-Plate Diffuse Optical Breast Tomography
    Arjun G Yodh; Fiscal Year: 2012
    ..Thus, as more information is acquired and analyzed, we expect diffuse optics to find a variety of niche applications in screening, diagnosis and cancer therapy monitoring...
  52. Phase 2 Study of CNTF on Photoreceptor Structure in Retinitis Pigmentosa
    JACQUE LYNNE DUNCAN; Fiscal Year: 2012
    ..However, adaptive optics scanning laser ophthalmoscopy (AOSLO) can produce images of individual cone photoreceptors in eyes with retinal ..
  53. Sub-Wavelength Imaging of Intracellular Metal Ions
    Joseph R Lakowicz; Fiscal Year: 2010
    ..However, the spatial resolution is limited to about 300 nm by the laws of diffractive optics. Methods to improve the spatial resolution are complex and not always compatible with cell imaging...
  54. Live Cell Interferometry for Quantifying Mass Transport in Cancer
    THOMAS ZANGLE; Fiscal Year: 2013
    ..individuals and a mentoring committee, from leading experts in cancer/cell biology and engineering disciplines in optics/microscopy, electronics and fluidics...
  55. Nanoprobe for High Resolution Hard X-ray Fluorescence Microscopy
    Gayle E Woloschak; Fiscal Year: 2010
    ..The aim of this proposal is to purchase and install a hard X-ray Bio-Nanoprobe with optimized optics, efficient detectors, tools for specimen positioning and cryogenic specimen environment...
  56. Short-Term Research Training for Optometry Students
    T Rowan Candy; Fiscal Year: 2013
    ..The potential areas of training include: Optics: including aberrations and retinal imaging, Biology: including molecular, biochemical mechanisms and pharmacology, ..
  57. Diffuse Optical Monitoring of Head and Neck Tumor Therapy
    Guoqiang Yu; Fiscal Year: 2013
    ..The capabilities of diffuse optics for continuously monitoring tumor hemodynamics and metabolism during therapy at the clinical bedside have recently ..
  58. Laser Device Development and Qualification to Enable Laser Tissue Welding
    CRAIG LENNON; Fiscal Year: 2010
    ..aim of the work is to demonstrate the feasibility of a prototype surgical laser system and handheld beam delivery optics to enable laser tissue welding for liver repair. In Phase I, Visotek will develop an air cooled...
  59. NOVEL DIAGNOSTICS WITH OPTICAL COHERENCE TOMOGRAPHY
    James G Fujimoto; Fiscal Year: 2013
    ..Aim 3. Develop new techniques for adaptive optics enhanced OCT We will develop an AO-OCT system for clinical use at NEEC...
  60. Intravital Multiphoton Microscope
    Florea Lupu; Fiscal Year: 2010
    ..NIR beam;2) a Zeiss Axio Imager Z1 motorized fluorescence microscope with DIC and high resolution water immersion optics;and 3) a Coherent Chameleon free Ultrafast II Ti:Sapphire laser system...
  61. Fluorescence Anisotropy-based Macromolecule Crystallization Screening
    MARC LEE PUSEY; Fiscal Year: 2011
    ..the Phase I instrument has indicated where improvements can be made in the plate set-up process, data collection optics, and electronics and the initial Phase II work will be to implement those improvements...
  62. Physical mechanisms of shock wave therapy in orthopedics
    THOMAS MATULA; Fiscal Year: 2010
    ..Shear waves will be measured using polarization optics and transparent bone models...
  63. Artificial Hand: A New Device for Ingested Foreign Bodies Removal
    VLADIMIR RUBTSOV; Fiscal Year: 2007
    ..illumination, and manipulation to develop an artificial "Seeing Hand," using commercially available imaging optics and fiber optics, and innovative modifications to existing devices developed at UCLA...
  64. Ultraprecision Diamond Machining of Conventional Non-Diamond Machinable Materials
    Gang Zhang; Fiscal Year: 2007
    ..It is an indispensable machining process for fabricating ultraprecision macro- and micro-optics and non-optical components for biomedical products used for biomedicine, biomedical analysis, diagnostics, and ..
  65. Port wine stain treatment for infants and young children
    Guillermo Aguilar; Fiscal Year: 2006
    ..mechanical engineering, with knowledge and experience in the emerging fields of photomedicine and biomedical optics required to launch a successful independent research career in biomedical engineering...
  66. FAST PHOTOSENSITIZED REACTIONS OF AROMATIC COMPOUNDS
    LEONARD GROSSWEINER; Fiscal Year: 1992
    ..by chromophores embedded in tissues can be investigated with the experimental and analytical methods of tissue optics. A diffuse optics spectrophotometer utilizing integrating spheres and optical fiber probe methods will be used for ..
  67. CONTACT LENSES AND MYOPIA (CLAMP) STUDY
    JEFFREY WALLINE; Fiscal Year: 2003
    ..Walline's qualifying examinations and his doctoral thesis, which will focus on his coursework in Physiological Optics and Preventive Medicine. Dr...
  68. BIOMEDICAL RESEARCH SUPPORT
    SAMUEL SHACKS; Fiscal Year: 1991
    ..and dual photon-counting detectors; upright and inverted microscopes with interchangable infinity-corrected optics; multi- channel plate-coupled intensified CCD video camera for previewing, selecting and focussing fields with ..
  69. Variable Power Phoropter
    James T Schwiegerling; Fiscal Year: 2010
    ..Adaptive optics (AO) phoropters have been demonstrated in research laboratories and systems based on reflective AO systems are ..
  70. KUMAKHOV OPTICS FOR CLINICAL DUAL-ENERGY ANGIOGRAPHY
    QI FAN XIAO; Fiscal Year: 1993
    ..Recent advances in Kumakhov optics utilizing x-ray capillary optics have demonstrated the ability to focus x-ray beams and to filter out high-energy ..
  71. Modeling the photon propagation for optical molecular imaging
    Wenxiang Cong; Fiscal Year: 2009
    ..The most popular model for biomedical optics is the diffusion approximation that approximately describes the interaction of photons with the biological tissue ..
  72. Multi-Resolution Corneal Topography (MRCT)
    EDWIN SARVER; Fiscal Year: 2006
    ..the specific aims are to develop the following: 1) optimized reflection target with LED back lighting; 2) electro-optics assembly; 3) optical head mechanical frame; 4) optical head enclosure; 5) system software; 6) mechanical interface ..
  73. Multi-Function Laser Scanning Microscope
    David Piston; Fiscal Year: 2009
    ..To assure experimental continuity, we will utilize much of our existing optics and accessory hardware on the new system, including the recently purchased Coherent Chameleon Ti:Sapphire laser...
  74. Adaptive Optics Imager for Study of Pediatric Retinal Disorders
    Anne Fulton; Fiscal Year: 2009
    ..hypotheses about the fovea, our group of eight investigators requests an ultra-high resolution multimodal adaptive optics retinal imager ("PSI Retinal Imager")...
  75. Mid-Career Investigator in Patient-Oriented Research
    John Nelson; Fiscal Year: 2007
    ..for the mentoring of young physicians interested in the emerging fields of photomedicine and biomedical optics. At least two fellows will be mentored at any given time...
  76. A 10-um resolution imager for soft X-ray emitters
    Roberto Accorsi; Fiscal Year: 2004
    ..the 3-10 keV range with 10-1_m resolution over a field of view of about 5 mm with a CCD camera and coded aperture optics. The specific aim of the proposed research is to build and test a soft X-ray camera of novel design based on coded ..
  77. R-axis IV++ Detector and Vari-Max Optics for X-ray Crystallographic Studies
    Mavis Agbandje McKenna; Fiscal Year: 2009
    ..which contains a Rigaku RUH3R X-ray generator and Right port shutter configuration with Max-Flux (blue) Confocal optics and R-Axis IV++ Image plate system) comes from the following considerations...