Summary: Physical motion, i.e., a change in position of a body or subject as a result of an external force. It is distinguished from MOVEMENT, a process resulting from biological activity.

Top Publications

  1. ncbi Improved optimization for the robust and accurate linear registration and motion correction of brain images
    Mark Jenkinson
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, Headington, United Kingdom
    Neuroimage 17:825-41. 2002
  2. pmc Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion
    Jonathan D Power
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 59:2142-54. 2012
  3. pmc The influence of head motion on intrinsic functional connectivity MRI
    Koene R A van Dijk
    Harvard University Department of Psychology, Center for Brain Science, Cambridge, MA 02138, USA
    Neuroimage 59:431-8. 2012
  4. pmc Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM
    Xueming Li
    The Keck Advanced Microscopy Laboratory, Department of Biochemistry and Biophysics, University of California, San Francisco UCSF, San Francisco, California, USA
    Nat Methods 10:584-90. 2013
  5. doi The B-matrix must be rotated when correcting for subject motion in DTI data
    Alexander Leemans
    CUBRIC, School of Psychology, Cardiff University, Park Place, Cardiff, UK
    Magn Reson Med 61:1336-49. 2009
  6. pmc Two-year-olds with autism orient to non-social contingencies rather than biological motion
    Ami Klin
    Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06519 1124, USA
    Nature 459:257-61. 2009
  7. doi Molecular identification of a retinal cell type that responds to upward motion
    In Jung Kim
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 452:478-82. 2008
  8. pmc Nonthermal ATP-dependent fluctuations contribute to the in vivo motion of chromosomal loci
    Stephanie C Weber
    Department of Biochemistry, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:7338-43. 2012
  9. pmc A differentially amplified motion in the ear for near-threshold sound detection
    Fangyi Chen
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, USA
    Nat Neurosci 14:770-4. 2011
  10. pmc ElNemo: a normal mode web server for protein movement analysis and the generation of templates for molecular replacement
    Karsten Suhre
    Information Génomique and Structurale UPR CNRS 2589, 31, Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Nucleic Acids Res 32:W610-4. 2004

Detail Information

Publications388 found, 100 shown here

  1. ncbi Improved optimization for the robust and accurate linear registration and motion correction of brain images
    Mark Jenkinson
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, Headington, United Kingdom
    Neuroimage 17:825-41. 2002
    Linear registration and motion correction are important components of structural and functional brain image analysis. Most modern methods optimize some intensity-based cost function to determine the best registration...
  2. pmc Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion
    Jonathan D Power
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 59:2142-54. 2012
    Here, we demonstrate that subject motion produces substantial changes in the timecourses of resting state functional connectivity MRI (rs-fcMRI) data despite compensatory spatial registration and regression of motion estimates from the ..
  3. pmc The influence of head motion on intrinsic functional connectivity MRI
    Koene R A van Dijk
    Harvard University Department of Psychology, Center for Brain Science, Cambridge, MA 02138, USA
    Neuroimage 59:431-8. 2012
    ..A confounding factor is head motion. Children move more than adults, older adults more than younger adults, and patients more than controls...
  4. pmc Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM
    Xueming Li
    The Keck Advanced Microscopy Laboratory, Department of Biochemistry and Biophysics, University of California, San Francisco UCSF, San Francisco, California, USA
    Nat Methods 10:584-90. 2013
    ..Using a newly developed single electron-counting detector, we confirmed that electron beam-induced motion substantially degrades resolution, and we showed that the combination of rapid readout and nearly noiseless ..
  5. doi The B-matrix must be rotated when correcting for subject motion in DTI data
    Alexander Leemans
    CUBRIC, School of Psychology, Cardiff University, Park Place, Cardiff, UK
    Magn Reson Med 61:1336-49. 2009
    ..However, the concomitant longer acquisition times increase the chances of subject motion adversely affecting the estimation of these measures...
  6. pmc Two-year-olds with autism orient to non-social contingencies rather than biological motion
    Ami Klin
    Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06519 1124, USA
    Nature 459:257-61. 2009
    Typically developing human infants preferentially attend to biological motion within the first days of life...
  7. doi Molecular identification of a retinal cell type that responds to upward motion
    In Jung Kim
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 452:478-82. 2008
    ..direction; because the lens reverses the image of the world on the retina, these cells detect upward motion in the visual field...
  8. pmc Nonthermal ATP-dependent fluctuations contribute to the in vivo motion of chromosomal loci
    Stephanie C Weber
    Department of Biochemistry, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:7338-43. 2012
    ..This motion seems random and is often attributed to brownian motion...
  9. pmc A differentially amplified motion in the ear for near-threshold sound detection
    Fangyi Chen
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, USA
    Nat Neurosci 14:770-4. 2011
    ..These effects depend nonlinearly on the stimulus sound pressure level. The timing difference and enhancement of vibrations are important for explaining how the noise problem is circumvented...
  10. pmc ElNemo: a normal mode web server for protein movement analysis and the generation of templates for molecular replacement
    Karsten Suhre
    Information Génomique and Structurale UPR CNRS 2589, 31, Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Nucleic Acids Res 32:W610-4. 2004
    ..The web server can be freely accessed at
  11. ncbi Errors and margins in radiotherapy
    Marcel van Herk
    Department of Radiotherapy, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam
    Semin Radiat Oncol 14:52-64. 2004
    ..Before treatment planning, a planning computed tomography scan is made. In particular, motion of skin with respect to the internal anatomy limits the reproducibility of this step, introducing a systematic ..
  12. ncbi The constructive nature of vision: direct evidence from functional magnetic resonance imaging studies of apparent motion and motion imagery
    R Goebel
    Max Planck Institut für Hirnforschung, Frankfurt a M, Germany
    Eur J Neurosci 10:1563-73. 1998
    ..magnetic resonance imaging was used to monitor activation changes of brain areas while subjects viewed apparent motion stimuli and while they were engaged in motion imagery...
  13. doi ON and OFF pathways in Drosophila motion vision
    Maximilian Joesch
    MPI for Neurobiology, Department of Systems and Computational Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany
    Nature 468:300-4. 2010
    b>Motion vision is a major function of all visual systems, yet the underlying neural mechanisms and circuits are still elusive...
  14. ncbi The management of respiratory motion in radiation oncology report of AAPM Task Group 76
    Paul J Keall
    Virginia Commonwealth University, USA
    Med Phys 33:3874-900. 2006
    ..external-beam radiation therapy of patients with thoracic, abdominal, and pelvic tumors affected by respiratory motion. This report describes the magnitude of respiratory motion, discusses radiotherapy specific problems caused by ..
  15. pmc A predisposition for biological motion in the newborn baby
    Francesca Simion
    Dipartimento di Psicologia dello Sviluppo e della Socializzazione, Universita di Padova, Via Venezia 8, 35131 Padua, Italy
    Proc Natl Acad Sci U S A 105:809-13. 2008
    An inborn predisposition to attend to biological motion has long been theorized, but had so far been demonstrated only in one animal species (the domestic chicken)...
  16. doi Head injury or head motion? Assessment and quantification of motion artifacts in diffusion tensor imaging studies
    Josef Ling
    The MIND Research Network, Albuquerque, New Mexico 87106, USA
    Hum Brain Mapp 33:50-62. 2012
    The relationship between head motion and diffusion values such as fractional anisotropy (FA) and mean diffusivity (MD) is currently not well understood...
  17. ncbi Perception of object trajectory: parsing retinal motion into self and object movement components
    Paul A Warren
    School of Psychology, Tower Building, Cardiff University, Cardiff, Wales, UK
    J Vis 7:2.1-11. 2007
    ..We hypothesized that neural mechanisms sensitive to the patterns of motion generated on the retina during self-movement (optic flow) play a key role in this process, "parsing" motion due to ..
  18. doi An in vivo verification of the intravoxel incoherent motion effect in diffusion-weighted imaging of the abdomen
    Andreas Lemke
    Department of Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany
    Magn Reson Med 64:1580-5. 2010
    ..vascular contribution to the measured apparent diffusion coefficient and to validate the Intra Voxel Incoherent Motion theory, the signal as a function of the b-value was measured in the healthy pancreas with and without suppression ..
  19. doi Biomechanical comparison of single-level posterior versus transforaminal lumbar interbody fusions with bilateral pedicle screw fixation: segmental stability and the effects on adjacent motion segments
    Hong Bo Sim
    Department of Neurological Surgery, Stanford University Medical Center, Stanford, California 94305 5327, USA
    J Neurosurg Spine 12:700-8. 2010
    ..The objectives of this biomechanical study were to compare PLIF and TLIF, each accompanied by bilateral pedicle screw fixation, with regard to the stability of the fused and adjacent segments...
  20. doi Catalytic Janus motors on microfluidic chip: deterministic motion for targeted cargo delivery
    Larysa Baraban
    Institute for Integrative Nanosciences, IFW Dresden, Helmholtzstrasse 20, D 01069 Dresden, Germany
    ACS Nano 6:3383-9. 2012
    ..This unique property allows a deterministic motion of the Janus particles at a large scale when guided in an external magnetic field...
  21. pmc Leg motion classification with artificial neural networks using wavelet-based features of gyroscope signals
    Birsel Ayrulu-Erdem
    Department of Electrical and Electronics Engineering, Bilkent University, Bilkent, 06800 Ankara, Turkey
    Sensors (Basel) 11:1721-43. 2011
    ..decomposition and provide them as input to multi-layer feed-forward artificial neural networks (ANNs) for leg motion classification...
  22. pmc NOMAD-Ref: visualization, deformation and refinement of macromolecular structures based on all-atom normal mode analysis
    Erik Lindahl
    Unité de Dynamique Structurale des Macromolécules, URA 2185 du C N R S, Institut Pasteur, 75015 Paris, France
    Nucleic Acids Res 34:W52-6. 2006
    ..The server can be accessed at the URL
  23. ncbi Respiratory motion artifacts on PET emission images obtained using CT attenuation correction on PET-CT
    Medhat M Osman
    Department of Internal Medicine, Division of Nuclear Medicine, Saint Louis University, 3635 Vista at Grand FOT2, St Louis, MO 63110, USA
    Eur J Nucl Med Mol Imaging 30:603-6. 2003
    ..The aim of this study was to evaluate for possible respiratory motion artifacts (RMA) in PET images attenuation corrected with CT from PET-CT in clinical patients...
  24. pmc Natural facial motion enhances cortical responses to faces
    Johannes Schultz
    Deptartment of Human Perception, Cognition and Action, Max Planck Institute for Biological Cybernetics, Tubingen, Germany
    Exp Brain Res 194:465-75. 2009
    The ability to perceive facial motion is important to successfully interact in social environments. Previously, imaging studies have investigated neural correlates of facial motion primarily using abstract motion stimuli...
  25. ncbi Prospective acquisition correction for head motion with image-based tracking for real-time fMRI
    S Thesen
    Siemens Medical Systems, MR Applications Development, Erlangen, Germany
    Magn Reson Med 44:457-65. 2000
    In functional magnetic resonance imaging (fMRI) head motion can corrupt the signal changes induced by brain activation...
  26. doi Beyond visual, aural and haptic movement perception: hMT+ is activated by electrotactile motion stimulation of the tongue in sighted and in congenitally blind individuals
    Isabelle Matteau
    Ecole d Optometrie, Universite de Montreal, Montreal, QC, Canada H3C 3J7
    Brain Res Bull 82:264-70. 2010
    The motion-sensitive middle temporal cortex (hMT+ complex) responds also to non-visual motion stimulation conveyed through the tactile and auditory modalities, both in sighted and in congenitally blind individuals...
  27. ncbi A motion phantom study on helical tomotherapy: the dosimetric impacts of delivery technique and motion
    Brian Kanagaki
    Department of Engineering Physics, University of Virginia, Charlottesville, VA 22908, USA
    Phys Med Biol 52:243-55. 2007
    ..However, previous theoretical and simulation studies reported that the effect of respiratory motion on statically planned tomotherapy treatments may cause substantial differences between the calculated and actual ..
  28. doi Salivary gland tumors: use of intravoxel incoherent motion MR imaging for assessment of diffusion and perfusion for the differentiation of benign from malignant tumors
    Misa Sumi
    Department of Radiology and Cancer Biology, Nagasaki University School of Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Radiology 263:770-7. 2012
    To prospectively evaluate the intravoxel incoherent motion (IVIM) parameters (microvascular volume fraction, f; pure diffusion coefficient, D; and perfusion-related incoherent microcirculation, D*) for differentiating between benign and ..
  29. doi Patching cardiac and head motion artefacts in diffusion-weighted images
    Marcel P Zwiers
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, HB Nijmegen, The Netherlands
    Neuroimage 53:565-75. 2010
    b>Motion artefacts are an important but often disregarded problem in diffusion-weighted imaging, which can readily lead to corrupt diffusion model estimations...
  30. doi Sound detection by the longfin squid (Loligo pealeii) studied with auditory evoked potentials: sensitivity to low-frequency particle motion and not pressure
    T Aran Mooney
    Marine Biological Laboratory, Woods Hole, MA 02543, USA
    J Exp Biol 213:3748-59. 2010
    ..Sound field pressure and particle motion components were measured from 30 to 10,000 Hz and acceleration stimuli were measured from 20 to 1000 Hz...
  31. pmc The vestibular system: multimodal integration and encoding of self-motion for motor control
    Kathleen E Cullen
    Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Trends Neurosci 35:185-96. 2012
    ..Recent experiments establishing that vestibular (self-motion) processing is inherently multimodal also provide insight into a set of interrelated questions...
  32. pmc Understanding biomolecular motion, recognition, and allostery by use of conformational ensembles
    R Bryn Fenwick
    Joint BSC IRB Research Programme in Computational Biology, Institute for Research in Biomedicine, IRB Barcelona, Spain
    Eur Biophys J 40:1339-55. 2011
    ..Finally, we discuss the limitations of conformational ensembles and highlight some potential applications for the future...
  33. doi Intravoxel incoherent motion in body diffusion-weighted MRI: reality and challenges
    Dow Mu Koh
    Department of Radiology, Royal Marsden Hospital, Downs Rd, Sutton SM2 5PT, UK
    AJR Am J Roentgenol 196:1351-61. 2011 apply more sophisticated analytic approaches, such as those based on the principles of intravoxel incoherent motion, which allows quantitative parameters that reflect tissue microcapillary perfusion and tissue diffusivity to be ..
  34. doi Modelling prostate motion for data fusion during image-guided interventions
    Yipeng Hu
    UCL Centre for Medical Image Computing, the Departmentof Medical Physics and Bioengineering, and the Department of ComputerScience, University College London, UK
    IEEE Trans Med Imaging 30:1887-900. 2011
    ..In this paper, the ability of a statistical shape/motion model, trained using finite element simulations, to predict and compensate for this source of motion is ..
  35. pmc Real-time single-molecule tethered particle motion experiments reveal the kinetics and mechanisms of Cre-mediated site-specific recombination
    Hsiu Fang Fan
    Department of Life Sciences and Institute of Genome Sciences, National Yang Ming University, 112, Taiwan
    Nucleic Acids Res 40:6208-22. 2012
    ..Using tethered particle motion (TPM), the Cre-mediated site-specific recombination process has been delineated, from beginning to end, at the ..
  36. doi Perceived causality influences brain activity evoked by biological motion
    James P Morris
    Duke University, Durham, North Carolina, USA
    Soc Neurosci 3:16-25. 2008
    ..who watched the hand and arm motions of an individual when that individual was, or was not, the cause of the motion. Subjects viewed a realistic animated 3D character who sat at a table containing four pistons...
  37. pmc Selectivity for spectral motion as a neural computation for encoding natural communication signals in bat inferior colliculus
    Sari Andoni
    Section of Neurobiology, Institute for Neuroscience, and Center for Perceptual Systems, The University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 31:16529-40. 2011 selective for the direction and velocity of signals sweeping upward or downward in frequency, termed spectral motion. We show that neurons in the auditory midbrain of Mexican free-tailed bats encode multiple spectrotemporal ..
  38. pmc Body-worn motion sensors detect balance and gait deficits in people with multiple sclerosis who have normal walking speed
    R I Spain
    Neurology Service and MS Center of Excellence West, Portland VA Medical Center and Department of Neurology, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Gait Posture 35:573-8. 2012
    ..02). During gait, people with MS had greater trunk angular range of motion in roll (medio-lateral flexion, p=0.017) and yaw (axial rotation, p=0.026) planes...
  39. pmc Mapping the organization of axis of motion selective features in human area MT using high-field fMRI
    Jan Zimmermann
    Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 6:e28716. 2011
    ..suggests similar response properties as in monkeys but failed to provide direct evidence for direction or axis of motion selectivity in human area MT...
  40. doi Emotions in motion: dynamic compared to static facial expressions of disgust and happiness reveal more widespread emotion-specific activations
    Sina Alexa Trautmann
    Department of Neuropsychology and Behavioral Neurobiology, Center for Cognitive Sciences, University of Bremen, Hochschulring 18, D 28359 Bremen, Germany
    Brain Res 1284:100-15. 2009
    ..involved in emotion perception of static and dynamic facial stimuli separately, and (3) to examine the impact of motion on the emotional processing of dynamic compared to static face stimuli...
  41. ncbi Motion, emotion and empathy in esthetic experience
    David Freedberg
    Department of Art History and Archeology, Columbia University, 826 Schermerhorn Hall, 1190 Amsterdam Avenue, New York 10027, USA
    Trends Cogn Sci 11:197-203. 2007
    ..Historical, cultural and other contextual factors do not preclude the importance of considering the neural processes that arise in the empathetic understanding of visual artworks...
  42. ncbi Cardiac diffusion MRI without motion effects
    Jiangang Dou
    MGH NMR Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Magn Reson Med 48:105-14. 2002
    We present a method for diffusion tensor MRI in the beating heart that is insensitive to cardiac motion and strain...
  43. ncbi Dynamics of motion signaling by neurons in macaque area MT
    Matthew A Smith
    Center for Neural Science, 4 Washington Place, New York University, New York, New York 10003, USA
    Nat Neurosci 8:220-8. 2005
    Most neurons in macaque area MT are selective for the direction of stimulus motion. By comparing direction selectivity for gratings and plaids, we classified MT neurons as pattern direction selective (PDS) or component direction selective ..
  44. pmc High-resolution, single-molecule measurements of biomolecular motion
    William J Greenleaf
    Department of Applied Physics, Stanford University, Stanford, California 94305 5030, USA
    Annu Rev Biophys Biomol Struct 36:171-90. 2007 outlines the principal approaches that have been used for high-resolution measurements of single-molecule motion, including centroid tracking, fluorescence resonance energy transfer, magnetic tweezers, atomic force microscopy, ..
  45. ncbi What is the best similarity measure for motion correction in fMRI time series?
    L Freire
    Service Hospitalier Frederic Joliot, CEA, Orsay, France
    IEEE Trans Med Imaging 21:470-84. 2002
    ..used by standard realignment packages (SPM and AIR) can lead to the detection of spurious activations, because the motion parameter estimations are biased by the activated areas...
  46. ncbi Interference effect of observed human movement on action is due to velocity profile of biological motion
    James Kilner
    University College London, London, UK
    Soc Neurosci 2:158-66. 2007
    ..We propose that the interference effect could be due either to the information the brain has about different types of movement stimuli or to the impact of prior experience with different types of form and motion.
  47. ncbi Hearing visual motion in depth
    Norimichi Kitagawa
    Department of Psychology, Tokyo Metropolitan University, 1 1, Minami Osawa, Hachioji shi, Tokyo 192 0397, Japan
    Nature 416:172-4. 2002
    ..This 'visual capture' also occurs in motion perception in which a static auditory stimulus appears to move with the visual moving object...
  48. doi Diagnosis of cirrhosis with intravoxel incoherent motion diffusion MRI and dynamic contrast-enhanced MRI alone and in combination: preliminary experience
    Jignesh Patel
    NYU Langone Medical Center, Department of Radiology, New York, New York, USA
    J Magn Reson Imaging 31:589-600. 2010
    To report our preliminary experience with the use of intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (DW-MRI) and dynamic contrast-enhanced (DCE)-MRI alone and in combination for the diagnosis of liver ..
  49. pmc Motion mode recognition and step detection algorithms for mobile phone users
    Melania Susi
    PLAN Group, Schulich School of Engineering, The University of Calgary, Calgary, AB, Canada
    Sensors (Basel) 13:1539-62. 2013
    ..When the sensor is in the hand, the situation becomes much more complex. First of all, the hand motion can be decoupled from the general motion of the user...
  50. ncbi Processive bidirectional motion of dynein-dynactin complexes in vitro
    Jennifer L Ross
    Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nat Cell Biol 8:562-70. 2006
    ..The unique motility characteristics observed may reflect the flexibility of the dynein structure that leads to an enhanced ability to navigate around obstacles in the cell...
  51. pmc Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique
    Jeff Fingler
    California Institute of Technology, Pasadena, California 91125, USA
    Opt Express 17:22190-200. 2009
    Phase variance-based motion contrast imaging is demonstrated using a spectral domain optical coherence tomography system for the in vivo human retina...
  52. pmc Real-time bulk-motion-correction free Doppler variance optical coherence tomography for choroidal capillary vasculature imaging
    Gangjun Liu
    Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USA
    Opt Express 19:3657-66. 2011
    ..For in-vivo imaging of human eyes, bulk-motion induced bulk phase must be identified and removed before using the color Doppler method...
  53. pmc Compressed-sensing motion compensation (CosMo): a joint prospective-retrospective respiratory navigator for coronary MRI
    Mehdi H Moghari
    Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Magn Reson Med 66:1674-81. 2011
    ..The NAV results in an increase in acquisition time to allow for resampling of the motion-corrupted k-space data...
  54. doi Optimizing preprocessing and analysis pipelines for single-subject fMRI. I. Standard temporal motion and physiological noise correction methods
    Nathan W Churchill
    Rotman Research Institute, Baycrest, Toronto, Ontario, Canada
    Hum Brain Mapp 33:609-27. 2012
    Subject-specific artifacts caused by head motion and physiological noise are major confounds in BOLD fMRI analyses. However, there is little consensus on the optimal choice of data preprocessing steps to minimize these effects...
  55. pmc Motion correction for myocardial T1 mapping using image registration with synthetic image estimation
    Hui Xue
    Siemens Corporate Research, Princeton, New Jersey, USA
    Magn Reson Med 67:1644-55. 2012
    ..However, respiratory motion limits its applicability and degrades the accuracy of T1 estimation...
  56. pmc Immunomagnetic nanoscreening of circulating tumor cells with a motion controlled microfluidic system
    Yu Yen Huang
    Department of Biomedical Engineering, The University of Texas at Austin, University Station, Austin, TX 78712 0238, USA
    Biomed Microdevices 15:673-81. 2013
    ..The proposed motion controlled microchip-based immunomagnetic system shows great promise as a clinical tool for cancer diagnosis and ..
  57. pmc High-throughput single-molecule analysis of DNA-protein interactions by tethered particle motion
    Thomas Plénat
    Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, 205 route de Narbonne, Toulouse, F 31077, France
    Nucleic Acids Res 40:e89. 2012
    Tethered particle motion (TPM) monitors the variations in the effective length of a single DNA molecule by tracking the Brownian motion of a bead tethered to a support by the DNA molecule...
  58. doi An alternative approach towards assessing and accounting for individual motion in fMRI timeseries
    Marko Wilke
    Department of Pediatric Neurology and Developmental Medicine, Children s Hospital, and Department of Neuroradiology, University of Tubingen, Germany
    Neuroimage 59:2062-72. 2012
    b>Motion is a significant problem for the analysis of functional MRI data...
  59. doi Effect of anterior-posterior and internal-external motion restraint during knee wear simulation on a posterior stabilised knee design
    Thomas M Grupp
    AESCULAP AG, Research and Development, Tuttlingen, Germany
    J Biomech 46:491-7. 2013
    ..for posterior stabilised knee designs, on wear, kinematics and particle release in comparison to linear motion restraint as required by the established ISO 14243-1:2002(E) protocol...
  60. doi Resolving the limb position effect in myoelectric pattern recognition
    Anders Fougner
    Department of Engineering Cybernetics, Norwegian University of Science and Technology, Trondheim, Norway
    IEEE Trans Neural Syst Rehabil Eng 19:644-51. 2011
    ..7% and 5.0%, respectively. Our study shows how sensor fusion (using EMG and accelerometers) may be an efficient method to mitigate the effect of limb position and improve classification accuracy...
  61. doi Toward an optimal distribution of b values for intravoxel incoherent motion imaging
    Andreas Lemke
    Department of Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany
    Magn Reson Imaging 29:766-76. 2011
    The intravoxel incoherent motion (IVIM) theory provides a framework for the separation of perfusion and diffusion effects in diffusion-weighted imaging (DWI)...
  62. doi Systematic accuracy and precision analysis of video motion capturing systems--exemplified on the Vicon-460 system
    Markus Windolf
    AO Research Institute, Research Services Group, Clavadelerstrasse 8, CH 7270 Davos, Switzerland
    J Biomech 41:2776-80. 2008
    With rising demand on highly accurate acquisition of small motion the use of video-based motion capturing becomes more and more popular. However, the performance of these systems strongly depends on a variety of influencing factors...
  63. pmc Quantitative characterization of subject motion in HR-pQCT images of the distal radius and tibia
    Miki Sode
    Joint Graduate Group in Bioengineering, University of California at San Francisco and Berkeley, San Francisco and Berkeley, CA, USA
    Bone 48:1291-7. 2011
    Image quality degradation due to subject motion is a common artifact affecting in vivo high-resolution peripheral quantitative computed tomography (HR-pQCT) of bones...
  64. pmc Motion-guided segmentation for cine DENSE MRI
    Bruce S Spottiswoode
    UCT MRC Medical Imaging Research Unit, University of Cape Town, South Africa
    Med Image Anal 13:105-15. 2009 presents a reliable and effective two-dimensional semi-automated segmentation technique that uses the encoded motion to project a manually-defined region of interest through time...
  65. pmc Higher-order motion sensitivity in fly visual circuits
    Yu Jen Lee
    Department of Neuroscience, Uppsala University, 751 24 Uppsala, Sweden
    Proc Natl Acad Sci U S A 109:8758-63. 2012
    In higher-order motion stimuli, the direction of object motion does not follow the direction of luminance change...
  66. doi Validity and reliability of GPS for measuring instantaneous velocity during acceleration, deceleration, and constant motion
    Matthew C Varley
    Institute of Sport, Exercise and Active Living, Victoria University, Melbourne, Victoria, Australia
    J Sports Sci 30:121-7. 2012
    ..However, researchers must account for the inherent match-to-match variation reported when using these devices...
  67. ncbi 4D MR imaging of respiratory organ motion and its variability
    M von Siebenthal
    Computer Vision Laboratory, ETH Zurich, 8092 Zurich, Switzerland
    Phys Med Biol 52:1547-64. 2007
    This paper describes a method for 4D imaging, which is used to study respiratory organ motion, a key problem in various treatments...
  68. pmc Cooperative transition between open and closed conformations in potassium channels
    Turkan Haliloglu
    Polymer Research Center, Bogazici University, Bebek Istanbul, Turkey
    PLoS Comput Biol 4:e1000164. 2008
    ..Reassuringly, the calculations manifested motion from the open (closed) towards the closed (open) conformation...
  69. pmc A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT
    Emmanuel S Burgos
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 106:13748-53. 2009
    ..demonstrate unique overlapping ATP and phosphoribosyltransferase sites, and establish reaction coordinate motion. NAMPT structures with beryllium fluoride indicate a covalent H247-BeF(3)(-) as the phosphohistidine mimic...
  70. doi Motion in cardiovascular MR imaging
    Andrew D Scott
    Cardiovascular Magnetic Resonance Unit, The Royal Brompton Hospital, London, England
    Radiology 250:331-51. 2009
    ..Despite this progress, many MR studies suffer from image degradation due to involuntary motion during the acquisition...
  71. pmc Sending signals dynamically
    Robert G Smock
    Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA
    Science 324:198-203. 2009
    ..The next stages in the signaling hierarchy-how multiple signals are integrated and how cellular signaling pathways are organized in space and time-present exciting challenges for the future, requiring bold multidisciplinary approaches...
  72. doi Motion and deformation of the target volumes during IMRT for cervical cancer: what margins do we need?
    Linda van de Bunt
    Department of Radiation Oncology, University Medical Center Utrecht, The Netherlands
    Radiother Oncol 88:233-40. 2008
    ..For cervical cancer patients the CTV consists of multiple structures, exhibiting complex inter-fraction changes. The purpose of this study is to use weekly MR imaging to derive PTV margins that accommodate these changes...
  73. pmc Transgenic mice reveal unexpected diversity of on-off direction-selective retinal ganglion cell subtypes and brain structures involved in motion processing
    Michal Rivlin-Etzion
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
    J Neurosci 31:8760-9. 2011
    On-Off direction-selective retinal ganglion cells (DSGCs) encode the axis of visual motion. They respond strongly to an object moving in a preferred direction and weakly to an object moving in the opposite, "null," direction...
  74. ncbi Mesoscale vertical motion and the size structure of phytoplankton in the ocean
    J Rodriguez
    Departamento de Ecologia, Universidad de Malaga, Campus de Teatinos, 29071 Malaga, Spain
    Nature 410:360-3. 2001
    ..Here we present an empirical model that relates the magnitude of mesoscale vertical motion to the slope of the size-abundance spectrum of phytoplankton in a frontal ecosystem...
  75. ncbi Adaptive prediction of respiratory motion for motion compensation radiotherapy
    Qing Ren
    Far East Application Support, Varian Medical Systems, Beijing, People s Republic of China
    Phys Med Biol 52:6651-61. 2007
    One potential application of image-guided radiotherapy is to track the target motion in real time, then deliver adaptive treatment to a dynamic target by dMLC tracking or respiratory gating...
  76. doi Motion adaptation and the velocity coding of natural scenes
    Paul D Barnett
    Discipline of Physiology, School of Medical Sciences, The University of Adelaide, Adelaide SA 5005, Australia
    Curr Biol 20:994-9. 2010
    ..Widely accepted correlation-based models for elementary motion detectors (EMDs) are sensitive to contrast and spatial structure and consequently generate ambiguous estimates of ..
  77. doi Young children with autism spectrum disorder do not preferentially attend to biological motion
    Dagmara Annaz
    Division of Psychology and Language Science, Department of Developmental Sciences, University College London, Chandler House, 2 Wakefield Street, London, UK
    J Autism Dev Disord 42:401-8. 2012
    Preferential attention to biological motion can be seen in typically developing infants in the first few days of life and is thought to be an important precursor in the development of social communication...
  78. ncbi Is movement variability important for sports biomechanists?
    Roger Bartlett
    School of Physical Education, University of Otago, Dunedin, New Zealand
    Sports Biomech 6:224-43. 2007
  79. pmc The use of wearable inertial motion sensors in human lower limb biomechanics studies: a systematic review
    Daniel Tik Pui Fong
    Department of Orthopaedics and Traumatology, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Sensors (Basel) 10:11556-65. 2010
    Wearable motion sensors consisting of accelerometers, gyroscopes and magnetic sensors are readily available nowadays. The small size and low production costs of motion sensors make them a very good tool for human motions analysis...
  80. pmc Developing single-molecule TPM experiments for direct observation of successful RecA-mediated strand exchange reaction
    Hsiu Fang Fan
    Department of Chemistry, National Taiwan University, Taipei, Taiwan
    PLoS ONE 6:e21359. 2011
    ..We have designed two experiments based on tethered particle motion (TPM) to investigate the fates of the invading and the outgoing strands during E...
  81. pmc Bayesian inference for improved single molecule fluorescence tracking
    Ji Won Yoon
    Department of Engineering and Department of Chemistry, University of Cambridge, Cambridge, United Kingdom
    Biophys J 94:4932-47. 2008
    ..The method is then applied to real experimental data...
  82. ncbi Normal and anomalous development of visual motion processing: motion coherence and 'dorsal-stream vulnerability'
    Oliver Braddick
    Department of Experimental Psychology, University of Oxford, Oxford, UK
    Neuropsychologia 41:1769-84. 2003
    Directional motion processing is a pervasive and functionally important feature of the visual system...
  83. doi Energy expenditure during daily activities as measured by two motion sensors in patients with COPD
    Vinicius Cavalheri
    Laboratório de Pesquisa em Fisioterapia Pulmonar LFIP, Departamento de Fisioterapia, Universidade Estadual de Londrina UEL, Rua Robert Koch, 60, Vila Operária, 86038 440 Londrina, Parana, Brazil
    Respir Med 105:922-9. 2011
    ..The aim of this study was to determine which daily activities are more demanding to patients with COPD and to compare the accuracy of EE estimation given by the pedometer Digiwalker SW701 (DW) and the multisensor SenseWear Armband (SAB)...
  84. pmc Motion vision is independent of color in Drosophila
    Satoko Yamaguchi
    Department of Genetics and Neurobiology, Biozentrum, University of Wurzburg, 97074 Wurzburg, Germany
    Proc Natl Acad Sci U S A 105:4910-5. 2008
    Whether motion vision uses color contrast is a controversial issue that has been investigated in several species, from insects to humans...
  85. pmc Enzymatic transition states and dynamic motion in barrier crossing
    Steven D Schwartz
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Chem Biol 5:551-8. 2009
  86. pmc Scalable rules for coherent group motion in a gregarious vertebrate
    Marie Hélène Pillot
    Universite de Toulouse, UPS, Centre de Recherches sur la Cognition Animale, Toulouse, France
    PLoS ONE 6:e14487. 2011
    ..This rule is shown to be in agreement with an adaptive strategy that is inherently scalable as a function of group size...
  87. doi Experience-dependent plasticity from eye opening enables lasting, visual cortex-dependent enhancement of motion vision
    Glen T Prusky
    Department of Physiology and Biophysics, Weill Cornell Medical College, Burke Medical Research Institute, White Plains, New York 10605, USA
    J Neurosci 28:9817-27. 2008
  88. ncbi Purkinje cells in posterior cerebellar vermis encode motion in an inertial reference frame
    Tatyana A Yakusheva
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 54:973-85. 2007
    ..It arises because motion sensors in the inner ear, the otolith organs, and the semicircular canals transduce self-motion in an egocentric ..
  89. pmc Neural correlates of motion-induced blindness in the human brain
    Marieke L Schölvinck
    Instituteof Cognitive Neuroscience, 17 Queen Square, London WC1N3AR, England
    J Cogn Neurosci 22:1235-43. 2010
    b>Motion-induced blindness (MIB) is a visual phenomenon in which highly salient visual targets spontaneously disappear from visual awareness (and subsequently reappear) when superimposed on a moving background of distracters...
  90. pmc Rapid perceptual switching of a reversible biological figure
    Stuart Jackson
    Cognitive Science, UCD School of Computer Science and Informatics, University College Dublin, Belfield, Dublin, Ireland, UK
    PLoS ONE 3:e3982. 2008
    ..In this paper we examine the temporal dynamics of perceptual reversals experienced with biological motion, comparing these dynamics to those observed with other ambiguous structure from motion (SFM) stimuli...
  91. pmc Crowding and hydrodynamic interactions likely dominate in vivo macromolecular motion
    Tadashi Ando
    Center for the Study of Systems Biology, School of Biology, Georgia Institute of Technology, 250 14th Street North West, Atlanta, GA 30318 5304, USA
    Proc Natl Acad Sci U S A 107:18457-62. 2010
    ..The reduction in diffusivity is very sensitive to macromolecular radius with the motion of the largest macromolecules dramatically slowed down; this is not seen if HI dominate...
  92. ncbi Hierarchical processing of sound location and motion in the human brainstem and planum temporale
    Katrin Krumbholz
    Institute of Medicine, Research Centre Julich, Julich, Germany
    Eur J Neurosci 21:230-8. 2005 assess which of the structures that are involved in general binaural processing are specifically specialized in motion processing...
  93. ncbi Vestibular perception and action employ qualitatively different mechanisms. I. Frequency response of VOR and perceptual responses during Translation and Tilt
    Daniel M Merfeld
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Room 421, MEEI, 243 Charles St, Boston, Massachusetts 02114, USA
    J Neurophysiol 94:186-98. 2005
    ..We used motion paradigms that provided identical sinusoidal inter-aural otolith cues across a broad frequency range...
  94. pmc Recognizing biological motion and emotions from point-light displays in autism spectrum disorders
    Evelien Nackaerts
    Department of Biomedical Kinesiology, Group Biomedical Sciences, Research Center for Movement Control and Neuroplasticity, KU Leuven, Heverlee, Belgium
    PLoS ONE 7:e44473. 2012
    ..Accuracy and reaction times were assessed from two observational tasks involving the recognition of 'biological motion' and 'emotions' from point-light displays (PLDs). Eye movements were recorded during the completion of the tests...
  95. pmc DNA translocation governed by interactions with solid-state nanopores
    Meni Wanunu
    Department of Biomedical Engineering and Department of Physics, Boston University, Boston, Massachusetts, USA
    Biophys J 95:4716-25. 2008
    ..These findings shed light on the transport properties of DNA in small pores, relevant for future nanopore applications, such as DNA sequencing and genotyping...
  96. pmc Dynein achieves processive motion using both stochastic and coordinated stepping
    Weihong Qiu
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Struct Mol Biol 19:193-200. 2012
    ..Here, we investigate how cytoplasmic dynein, a homodimeric, microtubule-based motor, achieves processive motion. To do this, we developed a versatile method for assembling Saccharomyces cerevisiae dynein heterodimers, using ..
  97. pmc Modeling the spatiotemporal cortical activity associated with the line-motion illusion in primary visual cortex
    Aaditya V Rangan
    Courant Institute of Mathematical Sciences and Center for Neural Science, New York University, New York, NY 10012, USA
    Proc Natl Acad Sci U S A 102:18793-800. 2005
    ..significance of the IDS cortical operating points by investigating our model cortex response to the Hikosaka line-motion illusion (LMI) stimulus-a cue of a quickly flashed stationary square followed a few milliseconds later by a ..
  98. ncbi How to get from A to B: strategies for analysing protein motion on DNA
    Stephen E Halford
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Eur Biophys J 31:257-67. 2002
    ..This review will discuss some of the strategies that have been developed to analyse the motion of proteins on DNA, with respect to both the random diffusion processes involved in target-site location by DNA-..
  99. pmc Mean square displacement analysis of single-particle trajectories with localization error: Brownian motion in an isotropic medium
    Xavier Michalet
    Department of Chemistry and Biochemistry, University of California at Los Angeles, 607 Charles E Young Drive E, Los Angeles, California 90095, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 82:041914. 2010
    ..MSD) analysis to extract reliable values of the diffusion coefficient D of a single particle undergoing Brownian motion in an isotropic medium in the presence of localization uncertainty...
  100. ncbi Comparison of the Newtonian and relativistic predicted trajectories for a low-speed periodically delta-kicked system
    Boon Leong Lan
    School of Engineering, Monash University, 46150 Petaling Jaya, Selangor, Malaysia
    Chaos 16:033107. 2006
    ..In the latter nonchaotic case, the difference grows much slower, for example, linearly on average...
  101. ncbi Change in protein flexibility upon complex formation: analysis of Ras-Raf using molecular dynamics and a molecular framework approach
    Holger Gohlke
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Proteins 56:322-37. 2004
    ..This implies that flexibility can be successfully predicted by identifying which bonds limit motion within a molecule and how they are coupled...

Research Grants75

  1. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..wound healing without scar formation would also be of significant benefit since scars over joints can limit limb motion and can have a strong psychological impact...
  2. The influence of air pollution mixtures on biomarkers of airway oxidative stress
    Roby Greenwald; Fiscal Year: 2013
    ..of ambient oxidants, the investigatorswill monitor activity intensity using a wearable device that contains a motion-sensing accelerometer and heart rate monitor...
  3. Investigating Mechanism of Intracellular Rotational Transport with Optical T
    Jeffrey N Anker; Fiscal Year: 2012
    ..rotational diffusion rate from ensembles of millions of cells, and is unable to localize particles or observe motion of individual particles and cells...
  4. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
    ..In skeletal muscle these signals make the difference between rest and motion, thus influencing multiple aspects of our life, including physical conditioning, metabolism, and even body weight...
  5. The Kallikrein/Kinin-Mast Cell Interaction in Volume Overload
    CHIH CHANG KEVIN WEI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The onset of volume overload (VO) sets in motion a sequence of biochemical and inflammatory events in the cardiac interstitial fluid (ISF) space that interact with cell surface molecules to dictate ..
  6. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..of chemical compounds to rescue the cardiac phenotypes of TS, I will test two different methods based on relative motion and calcium response in TS CMs using automated fluorescent microscopes...
  7. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..of chemical compounds to rescue the cardiac phenotypes of TS, I will test two different methods based on relative motion and calcium response in TS CMs using automated fluorescent microscopes...
  8. Adenosine and the Basal Forebrain in the Control of Behavioral State
    Robert E Strecker; Fiscal Year: 2012
    ..Cage motion is used to produce the periods of wakefulness...
  9. Human middle-ear imaging, physiology, and biomechanics
    CHARLES RICHARD STEELE; Fiscal Year: 2013
    ..Recent moment of inertia calculations suggest that the malleus switches from a hinging motion at low frequencies to a new twisting motion at high frequencies, in order to take advantage of the reduced inertia ..
  10. Wireless At-Risk Infant Monitoring System
    JASON HOLMSTEDT; Fiscal Year: 2012
    ..or in concert to monitor and report on a variety of baby vital signs, including ECG, pulse-ox, skin temperature, motion detection, EPG, and blood pressure...
  11. Complex I: Role of L Subunit in Proton Translocation
    Steven B Vik; Fiscal Year: 2011
    ..Second, the importance of piston-like motion will be tested by constructing cysteine residues in subunit L as sites for photo-affinity cross-linking to other ..
  12. Computer/Electrical Engineering
    Theodore Raphan; Fiscal Year: 2011
    ..This would make analysis of molecular structure more accessible to individual investigators. D. Human Motion Sickness and Vestibulo-Autonomic Studies (Dai/Cohen/Kaufmann/Raphan/ Straumann): 1...
  13. Use of Interactive Gaming for Enhanced Function after Spinal Cord Injury
    BEATRICE JENNY KIRATLI; Fiscal Year: 2011
    ..The purpose will be to evaluate muscles used, active range of motion, forces generated, heart rate, and other measurable attributes of the actions used during interactive video gaming ..
  14. Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
    Lauren M Pachman; Fiscal Year: 2013 damage to the small blood vessels;chronic inflammation is associated with persistent rash, loss of range of motion, deposits of calcifications and even the ability to perform tasks like climbing stairs or lifting objects and, ..
  15. Maternal Autoantibodies: Pathogenesis of Neonatal Lupus
    JILL PAMELA BUYON; Fiscal Year: 2013
    ..cardiocytes induces macrophage uptake by an Fc3R-dependent pathway and activation via TLR ligation, which set in motion the final step to irreversible scar...
  16. Detection of Liver Fibrosis Using IVIM Diffusion and DCE MRI in HCV
    Bachir Taouli; Fiscal Year: 2013
    ..validate non invasive magnetic resonance imaging (MRI) methods based on advanced diffusion (intravoxel incoherent motion diffusion MRI: IVIM DW-MRI) and dynamic contrast-enhanced MRI (DCE-MRI) for the detection of fibrosis and ..
  17. Characterizing Ankle Function During Sloped Locomotion For Prosthesis Development
    Alena Grabowski; Fiscal Year: 2012
    ..It is predicted that if biologically- equivalent mechanical power, compliance, and range of motion are supplied by the prosthetic ankle joint, people with a lower limb amputation will achieve equivalent ..
  18. Basic and Clinical Studies of Noise-Induced and Age-Related Hearing Loss
    Sharon G Kujawa; Fiscal Year: 2012
    ..shows that noise-exposures, even those that appear to result in fully reversible threshold shifts, actually set in motion a slow cell death cascade leading to the ultimate loss of roughly half of the neural elements throughout large ..
    Elton T Young; Fiscal Year: 2013
    ..AMPKs modify enzyme activities directly by phosphorylation and indirectly by setting in motion a complex transcriptional cascade that activates transcription factors that in turn activate downstream target ..
    Robert Fettiplace; Fiscal Year: 2013
    ..preparations and conditions to obtain accurate measures of the kinetics of transduction and active bundle motion. Hair cell responses will be measured in the isolated cochleae of both mammals and birds and will be combined with ..
  21. Community Ambulation Following Hip Fracture
    Jay Magaziner; Fiscal Year: 2013
    ..home delivered multi-component exercise program or a control intervention consisting of stretching and range of motion exercises, and low level transcutaneous electrical stimulation...
  22. Foot Bone Motion in End Stage Ankle Arthritis Patients
    William R Ledoux; Fiscal Year: 2012
    ..It is thought that joint replacement, which allows for more normal ankle motion, will not lea to aberrant dorsiflexory moments on the distal foot joints...
  23. The Effect of Behavioral and Physiological Factors on Obesity Risk in Children
    Karen B Dorsey; Fiscal Year: 2012 design and biostatistics as well as experience conducting research in clinical populations using direct motion monitoring with accelerometers to assess physical activity behaviors in overweight and non-overweight children...
  24. Rocker Shoes for Natural Immobilization of the Ankle during Single Limb Support
    Andrew H Hansen; Fiscal Year: 2012
    ..Recent work has shown that rocker shoes can be manufactured that lead to little or no motion at the ankle during single limb support (SLS) phase of walking, the period of highest compressive load on the ..
  25. Feasibility and Preliminary Efficacy of Yoga in Head and Neck Cancer Survivors
    Sheila H Ridner; Fiscal Year: 2013
    ..g., decreased range of motion in jaw/neck/ shoulder and altered posture)...
  26. Connective tissue and nervous system mechanisms of CAM therapies for low back pai
    Helene M Langevin; Fiscal Year: 2013
    ..For both Aims, primary outcome measures will be PCT thickness (in vivo), PCT shear plane motion (in vivo), dense PCT collagen bundle spacing (ex vivo), areolar PCT Type-1 procollagen content and areolar PCT ..
  27. Characterizing Patellofemoral Joint Stress Using Patient-Specific Models
    GARY BEAUPRE; Fiscal Year: 2012
    ..To date we have acquired advanced imaging data during upright weight-bearing, along with motion capture data and EMG data for fifty subjects with PF pain and for fifteen healthy controls...
  28. Molecular genetics of egg activation and pronuclear function in Drosophila
    ..The second Aim focuses on events set in motion by activation. We investigate YA, one of the few proteins known to act in these events...
  29. Presynaptic NMDAR Regulation of Substance P Release in the RVM After Injury
    ..the release of substance P, and that the up-regulation of these receptors after inflammatory injury sets in motion a positive feed-forward mechanism to sustain activity in pain facilitatory neurons in the RVM...
  30. Effect of Helicobacter pylori cell shape on pathogenesis
    ..pylori in the stomach (aim 1A). We will also directly probe the effect of cell shape on translational motion by measuring flagellar and cell body rotation for bacterial cell immobilized in gastric mucin gel at low pH (aim ..
  31. Neurotrophin-Secreting Muscle Stem Cell Therapy for Laryngeal Paralysis
    Stacey L Halum; Fiscal Year: 2013
    ..Current treatments for VFP are suboptimal in that they fail to restore dynamic motion. Recent studies suggest that persistent vocal fold immobility after recurrent laryngeal nerve (RLN) injury is not ..
  32. Mechanics of Inner Ear Hair Bundles
    ..FM-143 labeled mouse cochlear explants by attaching the probe to the bundle, displacing the probe and imaging the motion of the bundle under a confocal microscope...
  33. Collagenase degradation in extracellular matrix in aging
    Gary J Fisher; Fiscal Year: 2010
    ..This weakened mechanical tension promotes further expression of MMP-1, and thereby sets in motion a positive feedback pathway of skin connective tissue destruction...
    Ignacio Tinoco; Fiscal Year: 2013
    ..As the RNA molecule moves, or changes shape as it interacts with other RNAs or proteins, the beads move. Their motion can be seen in a microscope and thus the behavior of the RNA is assessed...
  35. In vivo Studies of Creatine Kinase Kinetics by 31P Magnetization Transfer MRS
    Adil Bashir; Fiscal Year: 2013
    ..time and signal contamination from the skeletal muscles in chest wall, which is further exacerbated by respiratory motion. A new approach to measure in vivo CK flux, overcoming the issues of lengthy examination time will be developed...
  36. Early Identification of Developmental Disorders in Infants
    B Eugene Parker; Fiscal Year: 2012
    ..The GEMINI system will exploit Barron Associates'patented six degrees-of- freedom motion monitoring capability and sophisticated signal processing to identify the key qualitative and quantitative ..
  37. Connective Tissue Mechanotransduction
    Helene M Langevin; Fiscal Year: 2012
    ..Many of these treatments involve stretching of soft tissues within or slightly beyond their usual range of motion, either manually or actively...
  38. High Throughput Screen for Novel Anti-Rheumatic Compounds
    Dale J Christensen; Fiscal Year: 2010
    ..Afflicting about 1 % of the population worldwide, RA causes pain, swelling, stiffness, and loss of motion in the joints, and, if unchecked, can cause irreversible joint damage, severe functional impairment, and premature ..
  39. Molecular mechanics of mutant cardiac myosin
    Jeffrey R Moore; Fiscal Year: 2013
    ..domain amplifies ATP dependent conformational changes originating in the myosin active site to generate force and motion. Given the importance of the light chain binding (neck/lever) domain of myosin in force production, it is not ..
  40. Cardiac function and PIP2
    Donald W Hilgemann; Fiscal Year: 2013
    ..and promoting cell death programs to be activated via mitochondrial signaling mechanisms that are set in motion. The experimental program addresses how Na/Ca exchangers may be removed from the cell surface membrane and how ..
  41. Allosteric regulation of the sensory protease DegS
    RANDALL VERNON MAULDIN; Fiscal Year: 2011
    ..The activated PDZ-protease serves as a molecular switch for the Ce response network, setting in motion a cascade of events that leads to the transcription of stress-response genes...
  42. Role of the Giant Protein Titin in Skeletal Muscle Structure and Function
    Henk L Granzier; Fiscal Year: 2013
    ..Passive stiffness determines the length range at which skeletal muscle operates and the maximal joint range of motion, both of which greatly influence functional activities and quality of life;we will study the role of the giant ..
  43. Middle-ear Mechanics in Normal and Pathological Ears
    John J Rosowski; Fiscal Year: 2013
    ..aim to exploit these methods and use new tools such as external-ear acoustic reflectance and laser holography of motion of the tympanic membrane in order to: a) investigate correlations between ear canal reflectance and umbo velocity ..
  44. Integrated imaging of the form and function of the beating embryonic heart
    ANDREW MARTIN ROLLINS; Fiscal Year: 2013
    ..We will utilize OCT to correct motion during OM imaging, obviating the need for excitation-contraction (E-C) decoupling drugs, thus enabling E-C ..
  45. Effects of Non-Exercise Activity on Cognitive Function in the Elderly
    Teresa J Buracchio; Fiscal Year: 2011
    ..Physical activity is measured by motion sensors that are strategically installed throughout subjects'homes and allow unobtrusive measurement of ..
  46. Kinetics of Chromosome Synapsis During Meiosis
    Jennifer C Fung; Fiscal Year: 2013 followed by imaging the Zip1 protein that has been previously coupled to GFP and used successfully to image the motion of fully synapsed chromosomes but not synapsis formation...
    Yanle Hu; Fiscal Year: 2013
    ..mainly because none of the current imaging techniques have the capability to track the respiration induced motion of the pancreatic tumor itself...
  48. Validity of Diet and Activity Measures in Men
    Meir Stampfer; Fiscal Year: 2013
    ..biomarker measures of diet and physical activity including doubly labeled water (DLW), urinary nitrogen (UN) and motion monitors. We therefore propose to conduct such a study among 750 men...
  49. Assessment of lung function in neonates and infants
    IULIAN CONSTANTIN RUSET; Fiscal Year: 2013
    ..Diffusion weighted imaging quantifies the Brownian-motion length-scale of gas atoms...
  50. Development of a 3D mammotomograph with novel techniques to overcome limitations
    Randolph L McKinley; Fiscal Year: 2010
    ..Our findings have indicated that a unique combination of complex motion capabilities together with modified system and bed components are required to meet this end...
  51. Nuclear magnetic Tirho relaxation in acute and chronic myocardial infarctions
    Walter R T Witschey; Fiscal Year: 2013
    ..research will be performed to develop methods to overcome magnetic field heterogeneity (static and RF fields) and motion artifacts associated specifically with T1A cardiac imaging...
  52. Use of Optogenetics to Assess the Role of Climbing Fibers in Motor Learning
    Rhea R Kimpo; Fiscal Year: 2013
    ..VOR is a reflexive eye movement that stabilizes image motion in the retina...
  53. Validation of MRI Microvascular Biomarkers in Pancreatic Cancer with Magnetic Nan
    ..g. DCE-MRI), which have limited applicability in the human pancreas secondary to abdominal motion, gas and their reliance on dynamic imaging. Furthermore, permeability measures (e.g...
  54. Mothers in Motion Program to Prevent Weight Gain in Overweight/Obese WIC Mothers
    Mei Wei Chang; Fiscal Year: 2013
    ..research team proposes to conduct a randomized controlled trial (RCT) to test the effectiveness of the Mothers In Motion intervention (MIM)...
  55. Three-dimensional cardiac accelerometry for cardiac monitoring
    Michael J Russell; Fiscal Year: 2010
    ..myocardial perfusion imaging (MPI) are the modalities commonly used for detecting ischemia and cardiac wall motion abnormalities...
    STEVEN LYNN KUNKEL; Fiscal Year: 2013
    The early events of severe sepsis set in motion a cascade of mechanisms, which significantly contribute to both the acute and chronic morbidity and mortality associated with this syndrome...
  57. VICTORY-Virtual Video Game Therapy for Substance Cessation and Recovery
    B Eugene Parker; Fiscal Year: 2013
    ..A virtual reality environment will be created using the inexpensive, wireless Kinect motion controller with the Microsoft Xbox360 gaming console, thereby lowering the cost barrier for treatment...
  58. Predict Near Future Bed Exit for Effective Intervention to Avoid Nighttime Falls
    THOMAS HENRY WHALEN; Fiscal Year: 2012
    ..The research uses a non-invasive, non-contact sensor array to collect heartbeat rate, respiratory rate, gross motion in bed, and bed-exit data...
  59. Characterization of Exudative Macular Degeneration and Diabetic Retinopathy Using
    Scott E Fraser; Fiscal Year: 2010
    ..Developing motion contrast capabilities of PC-OCT to be used with clinically available SDOCT systems can establish a new non-..
  60. ACE2 as a target for pulmonary hypertension therapeutics
    MOHAN K contact RAIZADA; Fiscal Year: 2010
    ..The progression of the fatal disease PH is set in motion by pulmonary vascular endothelial dysfunction...
  61. Stimulus processing in mammalian vestibular organs
    Ruth Anne Eatock; Fiscal Year: 2012
    Project Summary / Abstract Vestibular afferent nerve fibers convey head position and motion signals from the inner ear to the brain, where they drive reflexes controlling gaze, posture and balance and contribute to perceptions of ..
    Thomas C Foster; Fiscal Year: 2010
    ..However, the efficacy of E2 treatment is greatly reduced or nonexistent if therapy is set in motion several years after the onset of menopause...
  63. Integrating cell sorting and tissue shaping mechanisms during cornea maturation
    Philip M Iannaccone; Fiscal Year: 2010
    ..concurrent, executable model of vertebrate cornea maturation that seeks to determine whether intracellular motion exerted by epithelial cells can affect this process...
    Ann McDermott; Fiscal Year: 2002
    ..We propose studies of orientation of substrates in the enzyme pocket, and motion of substrates in the enzyme pocket, by new magnetic resonance methods...
  65. Stereoscopic motion-in-depth perception: fMRI and neurophysiological studies
    PAUL DOUGLAS GAMLIN; Fiscal Year: 2010 apply it in addressing a long-standing research question regarding the neural processing of stereoscopic 3-D motion. Stereo and motion are usually studied separately, and the cortical regions involved in the binocular perception ..
  66. Influence of Ankle Motion on Bilateral Amputee Gait
    Steven Gard; Fiscal Year: 2004
    We propose to investigate the effect of prosthetic ankle motion on the mechanics of bilateral lower-limb amputee gait...
    GEOFFREY BUSH; Fiscal Year: 2001
    ..Over the past 10 years it has been demonstrated that ocular responses to linear motion are inversely proportional to viewing distance...
  68. Human Spatial Disorientation and Misperception of Self-Motion in Three Dimensions
    JAN HOLLY; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The long-term goal is to better understand, explain, and predict human self-motion perception in three dimensions...
    Andrew Karduna; Fiscal Year: 2001
    ..of Occupational Safety and Health (NIOSH) has identified a clear epidemiological link between repetitive arm motion and shoulder disorders in the workplace, there are few scientific data available regarding the biomechanics of ..
  70. The development of depth perception from motion parallax in human infants
    ..The broad goal of this research is to examine the normal course of the development of depth perception and motion processing in infancy...
  71. Effects of Swallowing Therapy in Head and Neck Cancer
    Jerilyn Logemann; Fiscal Year: 2006
    ..Treatment for head and neck cancer often results in significant swallowing problems because of reduced range of motion of the larynx, tongue base and pharyngeal walls...
  72. Brain Motion During Blunt Impact
    Albert King; Fiscal Year: 2007
    ..injury mechanisms involved in blunt impact to the head, the following specific aims are proposed: 1) To map brain motion during head impact for a variety of angular velocities and for different directions of impact to determine brain ..
  73. Development of a Pre-Hospital Ultra-Wide Band Radar Cardiac Function Monitor
    Gregory Walcott; Fiscal Year: 2007
    ..LifeWave has developed an ultra-wideband radar sensor capable of detecting cardiac motion. We propose to develop the software algorithms that will allow this device to quickly determine whether or not a ..
  74. Function of the human tympanic membrane
    JEFFREY CHENG; Fiscal Year: 2009
    ..We propose to combine a new research technique to measure rapidly the motion of entire surface of the eardrum, with older techniques to measure stapes motion (a measure of the output of the ..
    Joseph Crisco; Fiscal Year: 2005
    ..we have developed a novel, non-invasive CT image-based technique to study three-dimensional (3-D) carpal bone motion in vivo...