weight bearing


Summary: The physical state of supporting an applied load. This often refers to the weight-bearing bones or joints that support the body's weight, especially those in the spine, hip, knee, and foot.

Top Publications

  1. ncbi Guidelines for standardization of radiostereometry (RSA) of implants
    Edward R Valstar
    Department of Orthopaedics, Leiden University Medical Center, The Netherlands
    Acta Orthop 76:563-72. 2005
  2. ncbi Tibio-femoral movement in the living knee. A study of weight bearing and non-weight bearing knee kinematics using 'interventional' MRI
    P Johal
    Department of Orthopaedics, St Mary s Hospital, W2 1NY London, UK
    J Biomech 38:269-76. 2005
  3. ncbi Anabolism. Low mechanical signals strengthen long bones
    C Rubin
    Musculo Skeletal Research Laboratory, Department of Biomedical Engineering, State University of New York, Stony Brook, New York 11794 2580, USA
    Nature 412:603-4. 2001
  4. ncbi A finite element model of the human knee joint for the study of tibio-femoral contact
    Tammy L Haut Donahue
    Department of Mechanical Engineering, Michigan Technological University, Houghton 49931, USA
    J Biomech Eng 124:273-80. 2002
  5. ncbi Increased knee joint loads during walking are present in subjects with knee osteoarthritis
    A J Baliunas
    Department of Orthopedic Surgery, Rush Medical College of Rush University, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Osteoarthritis Cartilage 10:573-9. 2002
  6. ncbi Off-loading the diabetic foot wound: a randomized clinical trial
    D G Armstrong
    Audie L Murphy Veterans Affairs Medical Center, Tucson, AZ 85723, USA
    Diabetes Care 24:1019-22. 2001
  7. ncbi Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis
    James K Roush
    Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    J Am Vet Med Assoc 236:67-73. 2010
  8. ncbi Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts
    L Vico
    Laboratoire de Biologie et Biochimie du Tissu Osseaux, INSERM E9901, GIP Exercice, Faculté de Médecine de St Etienne, France
    Lancet 355:1607-11. 2000
  9. ncbi Hip abduction moment and protection against medial tibiofemoral osteoarthritis progression
    Alison Chang
    Division of Rheumatology, Feinberg School of Medicine, Northwestern University, 240 East Huron, Chicago, IL 60611, USA
    Arthritis Rheum 52:3515-9. 2005
  10. ncbi Mapping the structural properties of the lumbosacral vertebral endplates
    J P Grant
    Department of Orthopaedics and Mechanical Engineering, University of British Columbia and Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada
    Spine (Phila Pa 1976) 26:889-96. 2001

Detail Information

Publications325 found, 100 shown here

  1. ncbi Guidelines for standardization of radiostereometry (RSA) of implants
    Edward R Valstar
    Department of Orthopaedics, Leiden University Medical Center, The Netherlands
    Acta Orthop 76:563-72. 2005
    ..Practical issues related to loading of the joint by weight bearing or other conditions, follow-up intervals, length of follow-up, radiation dose, and the exclusion of patients ..
  2. ncbi Tibio-femoral movement in the living knee. A study of weight bearing and non-weight bearing knee kinematics using 'interventional' MRI
    P Johal
    Department of Orthopaedics, St Mary s Hospital, W2 1NY London, UK
    J Biomech 38:269-76. 2005
    ..flexion under loaded and unloaded conditions, but the magnitude of rotation is greater and occurs earlier on weight bearing. With flexion plus tibial internal rotation, the pattern of movement follows that in neutral...
  3. ncbi Anabolism. Low mechanical signals strengthen long bones
    C Rubin
    Musculo Skeletal Research Laboratory, Department of Biomedical Engineering, State University of New York, Stony Brook, New York 11794 2580, USA
    Nature 412:603-4. 2001
    ..As the strain levels generated by this treatment are three orders of magnitude below those that damage bone tissue, this anabolic, non-invasive stimulus may have potential for treating skeletal conditions such as osteoporosis...
  4. ncbi A finite element model of the human knee joint for the study of tibio-femoral contact
    Tammy L Haut Donahue
    Department of Mechanical Engineering, Michigan Technological University, Houghton 49931, USA
    J Biomech Eng 124:273-80. 2002
    ..However, unrealistic constraints on rotations other than flexion/extension can result in relatively large errors in contact variables...
  5. ncbi Increased knee joint loads during walking are present in subjects with knee osteoarthritis
    A J Baliunas
    Department of Orthopedic Surgery, Rush Medical College of Rush University, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Osteoarthritis Cartilage 10:573-9. 2002
    ..Additionally, this study tests if changes in the knee angles, such as a reduced midstance knee flexion angle, or reduced sagittal plane moments previously identified by others as load reducing mechanisms are present in this OA group...
  6. ncbi Off-loading the diabetic foot wound: a randomized clinical trial
    D G Armstrong
    Audie L Murphy Veterans Affairs Medical Center, Tucson, AZ 85723, USA
    Diabetes Care 24:1019-22. 2001
    ..To compare the effectiveness of total-contact casts (TCCs), removable cast walkers (RCWs), and half-shoes to heal neuropathic foot ulcerations in individuals with diabetes...
  7. ncbi Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis
    James K Roush
    Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    J Am Vet Med Assoc 236:67-73. 2010
    To evaluate the effects of a food supplemented with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis.
  8. ncbi Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts
    L Vico
    Laboratoire de Biologie et Biochimie du Tissu Osseaux, INSERM E9901, GIP Exercice, Faculté de Médecine de St Etienne, France
    Lancet 355:1607-11. 2000
    ..Microgravity has been thought to induce osteoporosis because of reduced weight-bearing. However, up to now, few data have been available about its precise nature and timecourse...
  9. ncbi Hip abduction moment and protection against medial tibiofemoral osteoarthritis progression
    Alison Chang
    Division of Rheumatology, Feinberg School of Medicine, Northwestern University, 240 East Huron, Chicago, IL 60611, USA
    Arthritis Rheum 52:3515-9. 2005
    ..To test the hypothesis that a greater peak internal hip abduction moment is associated with a reduced likelihood of ipsilateral medial tibiofemoral osteoarthritis (OA) progression...
  10. ncbi Mapping the structural properties of the lumbosacral vertebral endplates
    J P Grant
    Department of Orthopaedics and Mechanical Engineering, University of British Columbia and Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada
    Spine (Phila Pa 1976) 26:889-96. 2001
    ..The center of the bone, where implants are currently placed, is the weakest part of the lumbar endplates and is not the strongest region of the sacral endplate...
  11. ncbi Potential strategies to reduce medial compartment loading in patients with knee osteoarthritis of varying severity: reduced walking speed
    Anne Mündermann
    Stanford University, Stanford, California 94305 3030, USA
    Arthritis Rheum 50:1172-8. 2004
    ..To determine whether reducing walking speed is a strategy used by patients with knee osteoarthritis (OA) of varying disease severity to reduce the maximum knee adduction moment...
  12. ncbi Characterization of cartilage metabolic response to static and dynamic stress using a mechanical explant test system
    P A Torzilli
    Laboratory for Soft Tissue Research, Hospital for Special Surgery, NY 10021, USA
    J Biomech 30:1-9. 1997
    ..Furthermore, the observed decreased metabolism may be more representative of the in situ tissue response than that of unloaded explants, in which we found an increasing rate of metabolism for up to 6 days after explant removal...
  13. ncbi Immediate weight bearing after uncemented total hip arthroplasty with an anteverted stem: a prospective randomized comparison using radiostereometry
    Truike M Thien
    Department of Orthopaedics, Sahlgrenska University Hospital, Molndal, Sweden
    Acta Orthop 78:730-8. 2007
    In uncemented total hip arthroplasty with hydroxyapatite coating, early weight bearing is frequently practiced but there is still not much evidence to support this recommendation.
  14. ncbi Effect of 5 weeks horizontal bed rest on human muscle thickness and architecture of weight bearing and non-weight bearing muscles
    Maarten D de Boer
    Instititute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Alsager, ST7 2HL, UK
    Eur J Appl Physiol 104:401-7. 2008
    ..The significant structural alterations of the GM and VL muscles highlight the rapid remodelling of muscle architecture occurring with disuse...
  15. ncbi Primary stability of four different implants for opening wedge high tibial osteotomy
    J D Agneskirchner
    Department of Trauma and Reconstructive Surgery, Henriettenstiftung Hannover, Germany
    Knee Surg Sports Traumatol Arthrosc 14:291-300. 2006
    ..The results suggest that the implant design strongly influences the primary stability of medial opening wedge tibial osteotomy. A rigid long plate fixator with angle-stable locking bolts yields the best results...
  16. ncbi Reproducibilty of partial weight bearing
    A Malviya
    Fairfield Hospital, Bury, 75 Stockdale Place, Edgbaston, Birmingham B15 3XH, UK
    Injury 36:556-9. 2005
    To find out whether partial weight bearing can be reproduced and retained.
  17. pmc Periprosthetic bone mineral density and fixation of the uncemented CLS stem related to different weight bearing regimes: A randomized study using DXA and RSA in 38 patients followed for 5 years
    Olof Wolf
    Department of Orthopedics, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 81:286-91. 2010
    ..Theoretically, bone ingrowth into the implant should benefit from initial partial weight bearing. We investigated whether the degree of postoperative weight bearing influences the periprosthetic bone mineral ..
  18. ncbi Partial weight bearing after surgery for fractures of the lower extremity--is it achievable?
    Attila Vasarhelyi
    Abteilung für Unfall und Wiederherstellungschirurgie Klinik und Poliklinik für Chirurgie, Universitat Rostock, Schillingallee 35, 18055 Rostock, Germany
    Gait Posture 23:99-105. 2006
    Partial weight bearing is a generally accepted principle of rehabilitation following trauma or reconstructive surgery of the lower extremity...
  19. ncbi A framework for the in vivo pathomechanics of osteoarthritis at the knee
    Thomas P Andriacchi
    Department of Mechanical Engineering, Stanford University, Division of Biomechanical Engineering, Stanford, CA 94305 4038, USA
    Ann Biomed Eng 32:447-57. 2004
    ..The integrated in vivo framework presented here will be helpful for the interpretation of laboratory experiments as well as for the development of new methods for the evaluation of OA at the knee...
  20. pmc Hypolocomotion, asymmetrically directed behaviors (licking, lifting, flinching, and shaking) and dynamic weight bearing (gait) changes are not measures of neuropathic pain in mice
    Jeffrey S Mogil
    Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada
    Mol Pain 6:34. 2010
    ..of digital video of mice with nerve injuries (chronic constriction or spared nerve injury), and automated assessment of locomotor behavior using photocell detection and dynamic weight bearing (i.e., gait) using the CatWalk system.
  21. pmc Factors influencing stresses in the lumbar spine after the insertion of intervertebral cages: finite element analysis
    Anne Polikeit
    M E Müller Institute for Biomechanics, University of Bern, Murtenstrasse 35, PO Box 30, 3010 Bern, Switzerland
    Eur Spine J 12:413-20. 2003
    ..Inserting an intervertebral cage markedly changed the load transfer. The altered stress distribution may trigger bone remodelling and explain damage of the underlying vertebrae...
  22. ncbi Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue
    Harun H Bayraktar
    Orthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, 2166 Etcheverry Hall, Berkeley, CA 94720 1740, USA
    J Biomech 37:27-35. 2004
  23. ncbi Modification of the in vivo four-point loading model for studying mechanically induced bone adaptation
    M R Forwood
    Department of Anatomical Sciences, University of Queensland, Brisbane, Australia
    Bone 23:307-10. 1998
    ..Adjustment of the loader also enables study of mechanical usage in murine tibia, an advantage with respect to the increasing variety of transgenic strains available in bone and mineral research...
  24. ncbi Rest-inserted loading rapidly amplifies the response of bone to small increases in strain and load cycles
    Sundar Srinivasan
    Dept of Orthopaedics, University of Washington, Seattle, WA 98104 2499, USA
    J Appl Physiol (1985) 102:1945-52. 2007
    ..In sum, the data of this study indicate that inserting a 10-s rest interval between each load cycle amplifies bone's response to mechanical loading, even within a peri-threshold range of strain magnitudes and cycle numbers...
  25. ncbi Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice
    Toshihiro Sugiyama
    Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
    Bone 43:238-48. 2008
    ..Together, these data suggest that in female C57BL/6 mice, under some but not all circumstances, mechanical loading exerts an osteogenic response with iPTH (1-34) in trabecular and cortical bone...
  26. ncbi Relationships among bone mineral densities, static alignment and dynamic load in patients with medial compartment knee osteoarthritis
    M Wada
    Division of Rehabilitation Medicine, Fukui Medical University, Shimoaizuki 23, Matsuoka-cho, 910-1193 Fukui, Japan
    Rheumatology (Oxford) 40:499-505. 2001
    ..CONCLUSIONS: Our results suggest that the bone mineral distribution of the proximal tibia is directly affected but lumbar BMD is not influenced by the local mechanical stress around the knee with medial compartment OA...
  27. ncbi Assessment of weight bearing changes and pharmacological antinociception in mice with LPS-induced monoarthritis using the Catwalk gait analysis system
    Willias Masocha
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, Kuwait
    Life Sci 85:462-9. 2009
    We evaluated the possibility of using the video-based Catwalk gait analysis method to measure weight bearing changes and for testing pharmacological antinociception in freely moving mice with lipopolysaccharide (LPS)-induced monoarthritis.
  28. ncbi Low effectiveness of prescribed partial weight bearing. Continuous recording of vertical loads using a new pressure-sensitive insole
    M Tveit
    Department of Orthopaedics, Sahlgrenska University Hospital, Gothenburg, Sweden
    J Rehabil Med 33:42-6. 2001
    To enable objective measurements of weight bearing in hip replacement patients a portable instrument set-up with an on-line registering pressure-sensitive insole was developed...
  29. ncbi Repair of articular cartilage defect in non-weight bearing areas using adipose derived stem cells loaded polyglycolic acid mesh
    Lei Cui
    Department of Plastic and Reconstructive Surgery, Shanghai 9th People s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai 200011, PR China
    Biomaterials 30:2683-93. 2009
    ..of using the resulting cell/scaffold constructs to repair full thickness articular cartilage defects in non-weight bearing area in porcine model within a follow-up of 6 months...
  30. ncbi Kinetic and kinematic characteristics of gait in patients with medial knee arthrosis
    Haydar Gok
    Ankara University School of Medicine, Department of Physical Medicine and Rehabilitation, Ankara, Turkey
    Acta Orthop Scand 73:647-52. 2002
    ..Some of these abnormalities may have etiologic implications, but others may represent secondary changes developed in part as a compensatory mechanism in knee OA...
  31. ncbi Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis
    S E Bove
    Department of Inflammation Pharmacology, Pfizer Global Research and Development, Ann Arbor Laboratories, Ann Arbor, MI 48105, USA
    Osteoarthritis Cartilage 11:821-30. 2003
  32. ncbi Generalized low bone mass of girls with adolescent idiopathic scoliosis is related to inadequate calcium intake and weight bearing physical activity in peripubertal period
    Warren T K Lee
    Department of Orthopaedics and Traumatology, 5 F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Osteoporos Int 16:1024-35. 2005
    ..The importance of preventing generalized osteopenia in the control of AIS progression during the peripubertal period warrants further study...
  33. ncbi Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression
    M M Knight
    IRC in Biomedical Materials, Queen Mary and Westfield College, London, UK
    Med Eng Phys 20:684-8. 1998
    ..72), although during static compression the cell deformation remained constant. This system may be used to examine cellular events under a range of dynamic mechanical stimuli...
  34. ncbi Comparison of capacitive versus resistive joint contact stress sensors
    L Martinelli
    Motion Analysis Laboratory, University Hospital Muenster, Muenster, Germany
    Clin Orthop Relat Res 447:214-20. 2006
    ..The resistive sensor is required for use where higher pressures are expected despite its inferior accuracy...
  35. ncbi High-frequency oscillatory motions enhance the simulated mechanical properties of non-weight bearing trabecular bone
    Engin Ozcivici
    Department of Biomedical Engineering, Psychology A Building, 3rd Floor, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    J Biomech 40:3404-11. 2007
    ..Here, we tested the hypothesis that high-frequency oscillations, applied in the absence of functional weight bearing, can be sensed by trabecular bone to produce a structure that is more efficient in sustaining applied loads...
  36. ncbi The initial phase of fracture healing is specifically sensitive to mechanical conditions
    Petra Klein
    Trauma and Reconstructive Surgery, Charite, Campus Virchow Klinikum, Humboldt University of Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    J Orthop Res 21:662-9. 2003
    ..Therefore, initial mechanical stability of an osteosynthesis should be considered an important factor in clinical fracture treatment...
  37. pmc Spinal muscle forces, internal loads and stability in standing under various postures and loads--application of kinematics-based algorithm
    A Shirazi-Adl
    Department of Mechanical Engineering, Ecole Polytechnique, P O Box 6079, Station Centre Ville, Montreal, Quebec H3C 3A7, Canada
    Eur Spine J 14:381-92. 2005
    ..The strength of the proposed model is in accounting for the synergy by simultaneous consideration of passive structure and muscle forces under applied postures and loads...
  38. ncbi Risk factors for lumbar disc degeneration: a 5-year prospective MRI study in asymptomatic individuals
    Achim Elfering
    Department of Psychology, University of Berne, Switzerland
    Spine (Phila Pa 1976) 27:125-34. 2002
    ..A longitudinal magnetic resonance imaging investigation of lumbar disc degeneration in asymptomatic individuals was conducted...
  39. ncbi A controlled randomized study of the effect of training with orthoses on the incidence of weight bearing induced back pain among infantry recruits
    Charles Milgrom
    Department of Orthopaedics, Hadassah University Hospital, Jerusalem, Israel
    Spine (Phila Pa 1976) 30:272-5. 2005
    ..Randomized controlled trial...
  40. ncbi The effects of weight bearing yoga training on the bone resorption markers of the postmenopausal women
    Manop Phoosuwan
    School of Sports Science, Chulalongkorn University, Bangkok, Thailand
    J Med Assoc Thai 92:S102-8. 2009
    This study was a preliminary report to investigate the effects of the weight bearing yoga training on both bone resorption marker and the quality of life of the postmenopausal women...
  41. ncbi Effect of axial load on anterior tibial translation when transitioning from non-weight bearing to weight bearing
    Randy J Schmitz
    University of North Carolina at Greensboro, Department of Kinesiology, 250 HHP, Greensboro, NC 27402, USA
    Clin Biomech (Bristol, Avon) 25:77-82. 2010
    ..We investigated the effects of increasing axial loads on anterior tibial translation and thigh muscle activity in healthy knees during transition from non-weight bearing to early weight bearing.
  42. ncbi The effect of preventive trimming on weight bearing and force balance on the claws of dairy cattle
    P P J van der Tol
    Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, The Netherlands
    J Dairy Sci 87:1732-8. 2004
    ..e., the wall) will be subjected to the highest pressures...
  43. ncbi Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element
    Roberto L de Souza
    Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK
    Bone 37:810-8. 2005
  44. ncbi Rehabilitation after hallux valgus surgery: importance of physical therapy to restore weight bearing of the first ray during the stance phase
    Reinhard Schuh
    Gait Analysis Laboratory, Foot and Ankle Center Vienna, Alserstrasse 43 8D, 1080 Vienna, Austria
    Phys Ther 89:934-45. 2009
    ..Operative treatment of people with hallux valgus can yield favorable clinical and radiographic results. However, plantar pressure analysis has demonstrated that physiologic gait patterns are not restored after hallux valgus surgery...
  45. ncbi Loss in mechanical contact of cementless acetabular prostheses due to post-operative weight bearing: a biomechanical model
    Chiara Maria Bellini
    Laboratory of Biological Structure Mechanics, Politecnico di Milano, Milan, Italy
    Med Eng Phys 29:175-81. 2007
    ..the first step was calculated and assumed as an index of variation in mechanical contact due to post-operative weight bearing. The results show that, due to hip loading, contact pressures given by press-fit increase in the postero-..
  46. ncbi Biofeedback training for partial weight bearing in patients after total hip arthroplasty
    Zoltan Pataky
    Service of Therapeutic Education for Chronic Diseases, World Health Organization Collaborating Centre, Department of Community Medicine, University Hospitals of Geneva, Geneva, Switzerland
    Arch Phys Med Rehabil 90:1435-8. 2009
    ..To evaluate a new biofeedback training method based on visual delivery of information in patients after total hip arthroplasty (THA)...
  47. pmc Early full weight bearing is safe in open-wedge high tibial osteotomy
    Justus Martijn Brinkman
    Limb Deformity Reconstruction Unit, Department of Orthopaedics, The Netherlands
    Acta Orthop 81:193-8. 2010
    ..Angle-stable implants offer superior initial stability. Early full weight bearing appears to be possible using these implants...
  48. ncbi The difference between actual and prescribed weight bearing of total hip patients with a trochanteric osteotomy: long-term vertical force measurements inside and outside the hospital
    Henri L Hurkmans
    Department of Physical Therapy, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Arch Phys Med Rehabil 88:200-6. 2007
    ..To determine whether patients load the operated leg at a prescribed weight-bearing target load during postoperative recovery...
  49. ncbi Pedobarographic findings in patients with knee osteoarthritis
    Evren Kul-Panza
    Physical Medicine and Rehabilitation Department, Marmara University School of Medicine, Istanbul, Turkey
    Am J Phys Med Rehabil 85:228-33. 2006
    ..The aim of this study was to evaluate pedobarographic findings and balance in knee osteoarthritis...
  50. ncbi Knee joint loading differs in individuals with mild compared with moderate medial knee osteoarthritis
    Laura E Thorp
    Rush University Medical Center, Chicago, Illinois 60612, USA
    Arthritis Rheum 54:3842-9. 2006
  51. ncbi Does partial weight bearing unload a healing bone in external ring fixation?
    Georg N Duda
    Research Laboratory, Department of Trauma and Reconstructive Surgery, Charite, Campus Virchow Klinikum, Humboldt University of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Langenbecks Arch Surg 388:298-304. 2003
    Partial weight bearing is thought to unload and protect the healing bone. Until now, there has been no objective method of assessing the amount of weight placed on the healing zone by the patient...
  52. ncbi The sulfation pattern of chondroitin sulfate from articular cartilage explants in response to mechanical loading
    Katrin Sauerland
    Department of Pharmacology and Toxicology, Rheinische Friedrich Wilhelms University of Bonn, Reuterstrasse 2b, D 53113, Bonn, Germany
    Biochim Biophys Acta 1638:241-8. 2003
  53. ncbi Backpacks on! Schoolchildren's perceptions of load, associations with back pain and factors determining the load
    Stefano Negrini
    Rehabilitation Unit, Don Carlo Gnocchi Foundation ONLUS, Care and Research Institute, Milan, Italy
    Spine (Phila Pa 1976) 27:187-95. 2002
    ..A cross-sectional study was conducted...
  54. ncbi Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
    Alexander G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 283:5866-75. 2008
  55. ncbi Anterior cervical plating reverses load transfer through multilevel strut-grafts
    D J DiAngelo
    from the School of Biomedical Engineering and the Department of Neurosurgery, University of Tennessee Memphis, Memphis, TN 38163, USA
    Spine (Phila Pa 1976) 25:783-95. 2000
    ..However, anterior cervical plating also reverses graft loads and excessively loads the graft in extension, which may promote pistoning and failure of multilevel constructs...
  56. ncbi Methods for evaluating the progression of osteoarthritis
    T P Andriacchi
    Stanford University, Department of Mechanical Engineering, CA 94301, USA
    J Rehabil Res Dev 37:163-70. 2000
    ..These new techniques promise to become powerful diagnostic tools to detect and characterize pathological load distributions across articular cartilage...
  57. ncbi Biomechanical assessment of transoral plate fixation for atlantoaxial instability
    F Kandziora
    Abteilung für Rheumaorthopädie, Orthopadische Universitatsklinik, Johann Wolfgang Goethe Universitat Frankfurt, Germany
    Spine (Phila Pa 1976) 25:1555-61. 2000
    ..In an experimental study using human cadaver specimens the biomechanical data of anterior atlantoaxial plating according to Harms were evaluated...
  58. ncbi A combined finite element and optimization investigation of lumbar spine mechanics with and without muscles
    V K Goel
    Department of Biomedical Engineering, University of Iowa, Iowa City
    Spine (Phila Pa 1976) 18:1531-41. 1993
    ..Future research directions based on the current model are presented...
  59. ncbi Development and pharmacological characterization of a rat model of osteoarthritis pain
    James D Pomonis
    Discovery Research, Purdue Pharma, L P, 6 Cedarbrook Drive, Cranbury, NJ 08512, USA
    Pain 114:339-46. 2005
    ..and assessed the joint degeneration with radiographic analyses and measured pain behavior using hind limb weight bearing. We found that injection of iodoacetate, but not papain, resulted in a chronic joint degeneration as measured ..
  60. ncbi Cartilage viability after repetitive loading: a preliminary report
    E Lucchinetti
    Laboratory for Soft Tissue Research, Hospital for Special Surgery, New York, New York 10021, USA
    Osteoarthritis Cartilage 10:71-81. 2002
    ..To assess matrix changes and chondrocyte viability during static and continuous repetitive mechanical loading in mature bovine articular cartilage explants...
  61. ncbi Treadmill ambulation with partial body weight support for the treatment of low back and leg pain
    David Joffe
    Department of Physical Therapy, Lahey Clinic, Burlington, MA, USA
    J Orthop Sports Phys Ther 32:202-13; discussion 213-5. 2002
    ..A single-subject experimental design using an A-B-A treatment protocol...
  62. ncbi The monosodium iodoacetate model of osteoarthritis: a model of chronic nociceptive pain in rats?
    Rachel Combe
    Pain Therapeutics, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT139NJ, UK
    Neurosci Lett 370:236-40. 2004
    ..Changes in hind paw weight distribution were also determined. Both punctate allodynia and a weight bearing deficit were observed in MIA-treated rats for up to 10 weeks...
  63. ncbi Contact stresses and fatigue life in a knee prosthesis: comparison between in vitro measurements and computational simulations
    Tomaso Villa
    Dipartimento di Ingegneria Strutturale and Dipartimento di Bioingegneria, Laboratory of Biological Structure Mechanics, Politecnico di Milano, Piazza Leonardo da Vinci 32, Milano 20133, Italy
    J Biomech 37:45-53. 2004
    ..The failure risk was estimated with a standard fatigue criterion on the basis of the results obtained from the FEM calculations. Experimental and computational results showed a positive matching...
  64. ncbi Consensus statements and recommended clinical procedures regarding loading protocols for endosseous dental implants
    David L Cochran
    Department of Periodontics, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    Int J Oral Maxillofac Implants 19:109-13. 2004
  65. ncbi NACOB presentation to ASB Young Scientist Award: Postdoctoral. The impact of boundary conditions and mesh size on the accuracy of cancellous bone tissue modulus determination using large-scale finite-element modeling. North American Congress on Biomechani
    C R Jacobs
    Department of Orthopaedics and Rehabilitation, Pennsylvania State University, Hershey 17033, USA
    J Biomech 32:1159-64. 1999
    ..In conclusion, we found that this approach is an effective method for determining the average trabecular hard tissue properties of human cancellous bone with an expected practical accuracy level better than 5%...
  66. ncbi Dynamic cervical plates: biomechanical evaluation of load sharing and stiffness
    D S Brodke
    Orthopedic Bioengineering Research Laboratory, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Spine (Phila Pa 1976) 26:1324-9. 2001
    ..An in vitro biomechanical study using a simulated cervical corpectomy model to compare the load-sharing properties and stiffnesses of two static and two dynamic cervical plates...
  67. ncbi Effect of load on articular cartilage matrix and the development of guinea-pig osteoarthritis
    L Wei
    Department of Orthopaedic Surgery, Huddinge University Hospital, Karolinska Institutet, Stockholm, S-141 86, Sweden
    Osteoarthritis Cartilage 9:447-53. 2001
    ..These changes eventually result in a cartilage devoid in aggrecan, as also has been demonstrated in advanced human OA. All of this makes primary guinea-pig OA a suitable model for studying early OA changes...
  68. ncbi Knee kinematics, cartilage morphology, and osteoarthritis after ACL injury
    Ajit M W Chaudhari
    Department of Orthopaedics, OSU Sports Medicine Center, Ohio State University, 2050 Kenny Road, Columbus, OH 43221, USA
    Med Sci Sports Exerc 40:215-22. 2008
  69. ncbi Gait biomechanics are not normal after anterior cruciate ligament reconstruction and accelerated rehabilitation
    P Devita
    Department of Exercise and Sport Science, East Carolina University, Greenville, NC 27858, USA
    Med Sci Sports Exerc 30:1481-8. 1998
    ..The purpose of this study was to compare lower extremity joint kinematics, kinetics, and energetics between individuals having undergone ACL reconstruction and accelerated rehabilitation and healthy individuals...
  70. ncbi One-dimensional viscoelastic behavior of fibroblast populated collagen matrices
    Jessica E Wagenseil
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S Euclid, CB 8228, St Louis, MO 63110, USA
    J Biomech Eng 125:719-25. 2003
    ..The peak force, hysteresis and shape of the force-stretch curve are affected by the stretch rate, rest period, stretch amplitude and the number and magnitude of preconditioning cycles...
  71. ncbi Loading history determines the velocity of actin-network growth
    Sapun H Parekh
    UCSF UC Berkeley Joint Graduate Group in Bioengineering, University of California at Berkeley, CA 94720, USA
    Nat Cell Biol 7:1219-23. 2005
  72. ncbi Trabecular bone tissue strains in the healthy and osteoporotic human femur
    B van Rietbergen
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    J Bone Miner Res 18:1781-8. 2003
    ..We made microfinite element models of a healthy and osteoporotic human femur and found that tissue-level strains in the osteoporotic femoral head were 70% higher on average and less uniformly distributed than those in the healthy one...
  73. ncbi Secondary gait changes in patients with medial compartment knee osteoarthritis: increased load at the ankle, knee, and hip during walking
    Annegret Mundermann
    Stanford University Medical Center, Stanford, California 94305 4038, USA
    Arthritis Rheum 52:2835-44. 2005
    ..This study tested the hypothesis that gait changes related to knee osteoarthritis (OA) of varied severity are associated with increased loads at the ankle, knee, and hip...
  74. ncbi Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow
    J You
    Department of Orthopaedics and Rehabilitation, Pennsylvania State University College of Medicine, Hershey 17033, USA
    J Biomech Eng 122:387-93. 2000
    ..These data suggest that, relative to fluid flow, substrate deformation may play less of a role in bone cell mechanotransduction associated with bone adaptation to routine loads...
  75. ncbi Time-dependent mechanical strength of 70/30 Poly(L, DL-lactide): shedding light on the premature failure of degradable spinal cages
    Theo H Smit
    VU University Medical Centre, Department of Physics and Medical Technology, Amsterdam, The Netherlands
    Spine (Phila Pa 1976) 33:14-8. 2008
    ..In vitro studies on the mechanical strength of 70/30 poly(l,dl-lactic acid) (70/30 PLDLLA) cages...
  76. ncbi In vivo skeletal imaging of 18F-fluoride with positron emission tomography reveals damage- and time-dependent responses to fatigue loading in the rat ulna
    Matthew J Silva
    Department of Orthopaedic Surgery, Washington University School of Medicine, 1 Barnes Jewish Hospital Plaza, Suite 11300 WP, St Louis, MO 63110, USA
    Bone 39:229-36. 2006
  77. ncbi Plantar pressure distribution during Tai Chi exercise
    De Wei Mao
    Department of Sports Science and Physical Education, Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Arch Phys Med Rehabil 87:814-20. 2006
    ..To describe and quantify the plantar pressure distribution characteristics during Tai Chi exercise and to explain the beneficial effect of Tai Chi on balance control and muscle strength when compared with normal walking...
  78. ncbi Pain-relieving effects of acupuncture and electroacupuncture in an animal model of arthritic pain
    Jin Hwan Oh
    Medical Research Center, Brain Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    Int J Neurosci 116:1139-56. 2006
    ..These results indicate that acupuncture and electroacupuncture may provide a potent strategy in relieving arthritic pain...
  79. ncbi Viability and volume of in situ bovine articular chondrocytes-changes following a single impact and effects of medium osmolarity
    Peter G Bush
    School of Biomedical and Clinical Laboratory Sciences, University Medical School, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, Scotland, UK
    Osteoarthritis Cartilage 13:54-65. 2005
  80. ncbi Partial versus unrestricted weight bearing after an uncemented femoral stem in total hip arthroplasty: recommendation of a concise rehabilitation protocol from a systematic review of the literature
    A M Hol
    Department of Physiotherapy, Rijnstate Hospital, Arnhem, The Netherlands
    Arch Orthop Trauma Surg 130:547-55. 2010
    ..of this systematic review was to find evidence-based support in the literature to allow immediate unrestricted weight bearing after primary uncemented total hip arthroplasty (THA)...
  81. ncbi Syndesmotic screw fixation in Weber C ankle injuries--should the screw be removed before weight bearing?
    David Paul Bell
    Department of Orthopaedic Surgery, Changi General Hospital, 2 Simei Street 3, Singapore 529889, Republic of Singapore
    Injury 37:891-8. 2006
    To compare the outcomes of Weber C ankle fractures treated with syndesmotic screw fixation where the screw was removed prior to weight bearing against those where the screw was left in situ indefinitely.
  82. ncbi Osteochondral defects in the human knee: influence of defect size on cartilage rim stress and load redistribution to surrounding cartilage
    Joseph H Guettler
    Department of Orthopaedic Surgery, William Beaumont Hospital, Royal Oak, Michigan, USA
    Am J Sports Med 32:1451-8. 2004
  83. ncbi Osteotomies around the knee: patient selection, stability of fixation and bone healing in high tibial osteotomies
    J M Brinkman
    Department of Orthopaedics, Limb Deformity Reconstruction Unit, Sint Maartenskliniek, Hengstdal 3, 6522 JV, Nijmegen, The Netherlands
    J Bone Joint Surg Br 90:1548-57. 2008
    ..This paper highlights recent research aimed at joint pressure redistribution, fixation stability and bone healing that has led to improved surgical techniques and a decrease of post-operative time to full weight-bearing...
  84. pmc Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue
    Luis Cardoso
    Department of Biomedical Engineering, The City College of New York, New York, New York 10031, USA
    J Bone Miner Res 24:597-605. 2009
  85. ncbi The effect of angled osteochondral grafting on contact pressure: a biomechanical study
    Jason Lee Koh
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Am J Sports Med 34:116-9. 2006
    ..Flush osteochondral plugs can reduce contact pressure compared with an empty defect in the articular cartilage. However, incongruities such as graft angulation have an unknown effect...
  86. ncbi Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha
    Victoria J Armstrong
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Royal College Street, London, United Kingdom
    J Biol Chem 282:20715-27. 2007
    ..Reduced effectiveness of bone cell responses to bone loading, associated with estrogen-related decline in ERalpha, may contribute to the failure to maintain structurally appropriate bone mass in osteoporosis in both men and women...
  87. ncbi Fixation stability of opening- versus closing-wedge high tibial osteotomy: a randomised clinical trial using radiostereometry
    J W H Luites
    Department of Research, Development and Education, Radboud University Nijmegen Medical Centre, P O Box 910, 6500HB Nijmegen, The Netherlands
    J Bone Joint Surg Br 91:1459-65. 2009
    ..Both give excellent initial stability and provide significantly improved knee function and reduction in pain, although the opening-wedge technique was more likely to produce the intended correction...
  88. ncbi Effects of damage in the articular surface on the cartilage response to injurious compression in vitro
    V Morel
    Cartilage Biomechanics Group, Ecole Polytechnique Federale de Lausanne EPFL, AA B019, CH 1015 Lausanne, Switzerland
    J Biomech 39:924-30. 2006
    ..Findings highlight microphysical factors important to cartilage mechanical injury, and suggest ways that macroscopic structural damage may accelerate or, in certain cases, possibly slow the progression of cartilage degeneration...
  89. ncbi Strain rate influences periosteal adaptation in mature bone
    Jeremy M Lamothe
    Faculty of Kinesiology, McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Alta, Canada
    Med Eng Phys 27:277-84. 2005
    ..Moreover, endosteal adaptation did not increase with strain rate. Understanding the nature of the stimuli to which bone cells respond to may underpin the development of non-pharmacological treatments devised to enhance bone mass...
  90. ncbi Effects of abnormal posture on capsular ligament elongations in a computational model subjected to whiplash loading
    Brian D Stemper
    Department of Neurosurgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, VA Medical Center, Milwaukee, WI 53226, USA
    J Biomech 38:1313-23. 2005
  91. ncbi Loading induces site-specific increases in mineral content assessed by microcomputed tomography of the mouse tibia
    J C Fritton
    Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
    Bone 36:1030-8. 2005
    ..Our finding that non-invasive loading increases the bone volume and fraction at a corticocancellous site by as much as 15% motivates exploring the use of mechanical loading to attain greater peak bone mass and inhibit osteoporosis...
  92. ncbi Additional weight bearing during exercise and estrogen in the rat: the effect on bone mass, turnover, and structure
    A M Tromp
    Department of Endocrinology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    Calcif Tissue Int 79:404-15. 2006
    ..The effects of mechanical loading on the trabecular bone of the femoral head were not significant. This study suggests that the effect of mechanical loading in the rat-with-backpack model mainly occurs at cortical bone sites...
  93. ncbi Comparison of biophysical stimuli for mechano-regulation of tissue differentiation during fracture healing
    Hanna Isaksson
    Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands
    J Biomech 39:1507-16. 2006
    ..This suggests that the deviatoric component may be the most significant mechanical parameter to guide tissue differentiation during indirect fracture healing...
  94. ncbi Ground contact characteristics of Tai Chi gait
    Ge Wu
    Department of Physical Therapy, University of Vermont, 305 Rowell Building, Burlington, VT 05401, USA
    Gait Posture 22:32-9. 2005
    ..The goal of this study was to quantify the biomechanical characteristics of foot-ground contact during a Tai Chi gait (TCG), one of the basic but common Tai Chi Chuan movements...
  95. ncbi No negative effects of bone impaction grafting with bone and ceramic mixtures
    J J Chris Arts
    From the Orthopaedic Research Laboratory, Department of Orthopedics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Orthop Relat Res 438:239-47. 2005
  96. pmc Sex differences in coupled knee motions during the transition from non-weight bearing to weight bearing
    Sandra J Shultz
    Department of Exercise and Sport Science, University of North Carolina at Greensboro, 1408 Walker Avenue, Greensboro, North Carolina 27402, USA
    J Orthop Res 27:717-23. 2009
    Knee ligament injuries frequently happen when the joint transitions from non-weight bearing (NWB) to weight bearing (WB)...
  97. ncbi Sympathetic nervous system does not mediate the load-induced cortical new bone formation
    Roberto L de Souza
    Department of Veterinary Basic Sciences, Royal Veterinary College, London, United Kingdom
    J Bone Miner Res 20:2159-68. 2005
  98. ncbi Unrestricted weight bearing and intensive physiotherapy after uncemented total hip arthroplasty
    H Strom
    Department of Orthopaedics, University of Uppsala, Sweden
    Scand J Surg 95:55-60. 2006
    ..The effectiveness of partial weightbearing after hip surgery has been questioned as well as the need of intensive physiotherapy...
  99. ncbi Tibiofemoral contact mechanics after serial medial meniscectomies in the human cadaveric knee
    Stephen J Lee
    The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Am J Sports Med 34:1334-44. 2006
    ..There is no consensus regarding the extent of meniscectomy leading to deleterious effects on tibiofemoral contact mechanics...
  100. ncbi Effects of independently altering body weight and body mass on the metabolic cost of running
    Lennart P J Teunissen
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    J Exp Biol 210:4418-27. 2007
    ..However, 74% is probably an overestimate of the metabolic demand of body weight to support itself because in reduced gravity conditions decrements in horizontal impulse accompanied decrements in vertical impulse...
  101. ncbi Calcium supplementation and weight bearing physical activity--do they have a combined effect on the bone density of pre-pubertal children?
    K A Ward
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, M13 9PT, UK
    Bone 41:496-504. 2007
    ..We speculate that gymnasts have already adapted their bones (geometry and vBMD) to the demands imposed upon them by the loading they are subjected to during gymnastics and do not benefit from additional calcium supplementation...

Research Grants67

  1. Characterizing Patellofemoral Joint Stress Using Patient-Specific Models
    GARY BEAUPRE; Fiscal Year: 2012
    ..abstract_text> ..
  2. Development of a Topical Choroid Plexus Factor Product to Accelerate Wound Healin
    ..The standard of care for these wounds has been unchanged for decades, and remains reduced weight bearing, debridement, antibiotics, and dressings...
  3. Comparative Effectiveness of Customary Fit and Strong! vs. Fit and Strong! Plus
    Susan L Hughes; Fiscal Year: 2013
    ..Reduced pain and stiffness in weight bearing joints may help reduce demand for total joint replacement surgery in this population.
  4. Intragenic Suppressors of McCune-Albright Syndrome Mutations
    ROBIN PALS RYLAARSDAM; Fiscal Year: 2010
    ..This project aims to provide important basic science information that can be used in the rational design of drugs for McCune-Albright Syndrome and other disorders cause by G-protein defects. ..
  5. Regulatory Mechanisms of Implant-Induced Osteolysis
    Yousef Abu-Amer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Degenerative conditions of large weight bearing joints resulting from aging and/or pathologic conditions such as arthritis and osteoporosis lead to surgical intervention approaches chiefly total joint ..
  6. Musculoskeletal Biomechanics of Gradient Walking in Obese Adults
    ..Brisk walking is a recommended and popular form of exercise but weight bearing exercise may be the source of the biomechanical loads that increase the risk of musculoskeletal injury and ..
  7. Mechanotransduction Approach to Improve Bone Quality in Osteogenesis Imperfecta
    Charlotte L Phillips; Fiscal Year: 2012
    ..negative molecular mechanisms [G610C/+ (models human type I and IV OI)] to investigate the impact of non-weight bearing (swimming) and weight bearing (treadmill) exercise on muscle strength and bone quality and strength...
    PATRICK WILLIAM MANTYH; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Fracture healing of a weight bearing bone is unique in that loading of the injured bone is required for effective healing of the bone...
  9. A comparative efficacy study: treatments of non-healing diabetic foot ulcers
    Roslyn R Isseroff; Fiscal Year: 2013
    ..Our work could provide not only important savings to our health care system, but also improved access to limb and life saving therapies for healing DFU to millions of affected individuals. ..
  10. Obesity and bone development in young girls
    Scott B Going; Fiscal Year: 2013
    ..We expect to clarify the currently controversial relationships and provide critical information needed to develop efficacious interventions for optimal bone development. ..
  11. A Systems Genetics Approach to Fracture Healing
    ..be considered a complex trait that is defined by the regain in mechanical competence that allows resumption of weight bearing. As a complex trait, fracture healing is the result of the functional contributions of multiple cell types...
  12. Anterior Cruciate Ligament Reconstruction and the Initiation of Osteoarthritis
    Thomas P Andriacchi; Fiscal Year: 2013
    ..2.) To determine if there are detectable thickness changes in the weight bearing regions of tibiofemoral cartilage over a 2 year period following ACL reconstruction that are greater than a ..
  13. The In Vivo Biomechanics of Lateral Ankle Ligament Injury and Reconstruction
    Louis E DeFrate; Fiscal Year: 2010
    ..These data will help to identify mechanisms leading to joint degeneration after these injuries and may lead to better reconstruction techniques. ..
  14. Silk Fibroin Small-Molecule Drug Carriers for the Treatment of Osteoarthritis
    TIMOTHY KARIITHI MWANGI; Fiscal Year: 2013
  15. Management of Cancer-Treatment-Induced Bone Loss
    LUKE JOSEPH PEPPONE; Fiscal Year: 2013
    ..Dr. Peppone will use the training and data obtained by this award to develop into an independent clinical researcher in the cancer control field. ..
  16. Musculoskeletal Response to Partial Weight Bearing
    Mary L Bouxsein; Fiscal Year: 2010
    ..Our long term goal is to identify new targets and treatments for preventing musculoskeletal deterioration in situations of reduced mechanical loading. ..
  17. A Patient Activation Intervention to Enhance Bone Health
    Fredric D Wolinsky; Fiscal Year: 2013
    ..g., weight bearing exercise), Calcium/Vitamin D supplementation, and pharmacotherapy when indicated...
    Adetunji T Toriola; Fiscal Year: 2013
  19. Innovative Biofabrication of 3D Nano-Biocomposites for Repair of Osteochondral De
    LAURIE O'ROURKE; Fiscal Year: 2012
    ..Surgical treatment of large osteochondral defects is often accomplished by transferring a non-weight bearing section of bone and cartilage to the defect...
  20. Enabling forelimb function with agonist drug and epidural stimulation in SCI
    Daniel Lu; Fiscal Year: 2013
    ..If successful, this could represent the beginning of a paradigm shift in the use of minimally invasive strategies combined with rehabilitative approaches to realize significant improvement in upper limb function after paralysis. ..
  21. Effects of Exercise Training on Fluid Instability in Heart Failure Patients
    ANDREA M BOYD; Fiscal Year: 2013
    ..Data Analysis: Statistical analysis will utilize a longitudinal mixed-effects regression model, modeling variability over time for the subjects individually, as well as, within groups. ..
  22. Controlling mechanical signal transduction to treat osteoarthritis
    WOLFGANG B LIEDTKE; Fiscal Year: 2013
    ..Beyond single-trauma induced joint injury, we also see as a clear target the more chronic joint injury facilitated by obesity. ..
    Jacquelin Perry; Fiscal Year: 2002
    ..This also is a significant clinical problem in those patients with incomplete SCI. Weight bearing demands on the shoulder joint from ambulation with an assistive device have been implicated...
  24. In vivo ACL Reconstruction Biomechanics
    Guoan Li; Fiscal Year: 2012
  25. Image-Guided Workstation and Tools for the Treatment of Bone Defects
    Mehran Armand; Fiscal Year: 2013
    ..With less-invasive approaches patients may start normal weight bearing immediately after the surgery...
  26. Re-training locomotor circuitry in a rat model of Spinal Cord Injury
    David S K Magnuson; Fiscal Year: 2010
    ..In addition, we will begin to look at the mechanisms of rehabilitation associated plasticity using a custom made array to detect changes in mRNA levels in spinal cord tissue following different training protocols. ..
    Michael J Mueller; Fiscal Year: 2010
    ..Little data exists on the effect of exercise on people with DM+PN and no data support the restriction to limit weight bearing exercise in those with DM+PN...
  28. Effect of Power Seat Function Usage on Tissue Viability in Wheelchair Users with
    Yih Kuen Jan; Fiscal Year: 2010
    ..The PIs'method will provide insight into the mechanism of blood flow response to PSF usage settings. Results from this study will provide objective evidence to support the use of PSF for needed pathological populations. ..
    CLAIRE FARLEY; Fiscal Year: 2000
    ..Finally, our research will begin applying knowledge of the neural control of joint stiffness to understanding the mechanics of a natural activity that is performed by all legged animals, locomotion. ..
  30. Osteogenic synthetic bone grafts for the repair of musculoskeletal defects
    Jie Song; Fiscal Year: 2012
    Harold Kitaoka; Fiscal Year: 2001
    The arch of the foot is important in performing activities to provide a stable base for weight bearing, flexibility to accommodate different ground conditions, and also to dissipate loads from weight bearing...
  32. Axiom zeego shared instrument grant
    Rebecca Fahrig; Fiscal Year: 2010
    ..The system provides an important bridging diagnostic and image guidance technology that will help move new therapies into the clinic. ..
  33. Serotonergic facilitation of spinal stepping by epidural stimulation: mechanisms
    REGGIE EDGERTON; Fiscal Year: 2012
  34. Hormone Mediated Knee Joint Laxity and Neuromechanics
    SANDRA SHULTZ; Fiscal Year: 2009
    ..We will then measure males and females on weight bearing knee joint neuromechanics at these specified time points to examine the independent and combined effects of ..
  35. Injectable weight-bearing bone grafts for healing of tibial plateau fractures
    Joseph C Wenke; Fiscal Year: 2013
  36. Restitution of Lubrication in ACL Deficient Joints Preventing Wear
    Gregory Jay; Fiscal Year: 2009
    ..PRG4) null mice which have a normal articular surface at birth and, by contrast, surface fibrillation after weight bearing begins...
  37. Measuring In-Socket Residual Limb Volume Fluctuation
    Joan E Sanders; Fiscal Year: 2013
    ..Potentially, the efforts described here can be extended to other areas where devices require a secure and intimate fit with human tissues, including trans-fermoral prosthetics, upper-limb prosthetics, and orthotics. ..
    G Fitzgerald; Fiscal Year: 2007
    ..Recently, there has been increasing evidence that alterations in lower extremity biomechanical factors during weight bearing activities, such as, alterations in movement and muscle activity patterns, ground reaction forces, and lower ..
  39. Neural Mechanisms Underlying Acupuncture Analgesia
    Jin Chung; Fiscal Year: 2007
    ..This is shown by the finding the EA results in about 40% recovery of weight bearing by the hind limb with ankle sprain...
  40. Mechanical Intervention in Children with Cerebral Palsy
    Tishya Wren; Fiscal Year: 2005
    ..These subjects will undergo an additional 6 months of weight bearing without vibration following the same schedule to serve as an internal control...
  41. Medial Collapse Movement Impairments associated with Patellofemoral Pain
    GRETCHEN SALSICH; Fiscal Year: 2009
    ..Ultimately, the number of individuals with PFP, and the disability and cost associated with this condition would be reduced. ..
  42. ActiveImplant Prosthesis for Lower Limb Amputees
    JOHN FAGO; Fiscal Year: 2007
    ..distal femur above the knee do not provide an optimum solution for interfacing with a prosthetic socket for weight bearing and ambulation...
  43. Shoulder Pain in Spinal Cord Injury (SCI): A Longitudinal Study
    Sara J Mulroy; Fiscal Year: 2010
    ..Chronic shoulder pain after SCI has been associated with the repetitive weight bearing of wheelchair propulsion (WCP), but a causal relationship has not been established...
  44. A nanostructured approach to complex tissue scaffolds and smart implants
    Jie Song; Fiscal Year: 2012
    ..abstract_text> ..
    Richard Tsika; Fiscal Year: 2009
    ..little is known about how the integrative biological response to decreased mechanical loading [hindlimb non-weight bearing (NWB)] leads to fiber-type shifts and altered transcriptional regulation of MyHC genes...
    Timothy Lohman; Fiscal Year: 2000
    ..The exercise program (progressive resistance exercise and weight bearing aerobic exercise) is designed to provide high strain magnitudes, rates and a diverse distribution, all thought ..
  47. Pittsburgh Older Americans Independence Center
    Susan L Greenspan; Fiscal Year: 2013
    ..perspectives about the interface between balance and mobility, especially the role of control of motion during weight bearing activity...
  48. Locus of Care & Pressure Ulcers After Hip Fracture
    Mona Baumgarten; Fiscal Year: 2004
    ..in recent years, including improved surgical techniques, earlier surgical repair, and earlier postoperative weight bearing. Since the advent of prospective payment to hospitals, the length of hospital stay for hip fracture has ..
    Edmund Chao; Fiscal Year: 2000
    ..A successful development of this implant system and the fixation concept will have significant application in general reconstructive orthopedic problems. ..
  50. Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training
    CATHERINE JANKOWSKI; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
    EDELLE FIELD FOTE; Fiscal Year: 2001
    ..manifest in the resulting gait pattern as aberrant temporal relationships between muscle groups, deficits in weight bearing capacity and inappropriate muscle activity such as prolonged stance phase, clonus and "scissoring...
    VAN MOW; Fiscal Year: 1990
    ..OA changes in joint cartilage appear to be irreversible? "Disuse" of the knee will be induced by preventing weight bearing for specified periods of time, excessive exercise will be achieved by a specified treadmill exercise regime, ..
    Barbara Resnick; Fiscal Year: 2002
  54. Transduction of Mechanical Signals in Cartilage
    CHRISTINE TOWLE; Fiscal Year: 2005
    ..The research is expected to define the mechanism(s) whereby cartilage deformation activates IL-1 receptor-dependent signaling pathways and modulates cartilage metabolism. ..
    Carol Sedlak; Fiscal Year: 2002
    ..knowledge of osteoporosis and to affect the dependent variables which are the OPBs (increased calcium intake, weight bearing exercise, smoking cessation, alcohol intake moderation, hormonal replacement therapy and non-hormonal drug ..
  56. Inverse Dynamics Using Instrumented Assistive Technology
    W Selbie; Fiscal Year: 2002
    ..A walker is used to provide support, reduce weight bearing on the lower limbs, and therefore to minimize the likelihood of falls. There were, however, over 118...
  57. HRT Decision Support for Women with Mobility Impairment
    Heather Becker; Fiscal Year: 2003
    ..Because they enter menopause with decreased weight bearing and aerobic activity histories, they may be at greater risk for Osteoporosis and cardiovascular disease...
  58. Combined Gene Therapy/Tissue Engineered Cartilage Repair
    Daniel Grande; Fiscal Year: 2001
    ..evaluate this GETE technology in the repair of knee articular cartilage defects in a large animal (sheep) weight bearing joint model...
  59. Dual-color tumor-host imaging models
    Meng Yang; Fiscal Year: 2003
    ..Resulting HJCs will be compared to the standard to determine the interactions of each variable, and the acceptable range of values from each variable that will produce HJCs within 1 cm of the standard. ..
  60. Extending Ultrasound Elastography to Manual Treatment Methods
    John Triano; Fiscal Year: 2009
    ..that arise from small amplitude motions during continuous passive motion (CPM) clinical procedures and in weight bearing postures...
    Karyn Esser; Fiscal Year: 1999
  62. An Assistive Wardrobe to Support Dressing Independence
    Margaret Calkins; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
    ERNEST MARSOLAIS; Fiscal Year: 2000
    ..Lack of weight bearing makes bones weak and easily broken, and lack of use of joints allows them to become contracted and unable to ..
    Krista Vandenborne; Fiscal Year: 1999
    ..We anticipate that the ability to locally manipulate muscle adaptation and growth in the elderly population, especially in the face of secondary atrophy, will be of great clinical importance. ..
  65. IGF-1 Gene transfer to accelerate muscle recovery
    Krista Vandenborne; Fiscal Year: 2005
    ..In addition, we anticipate that this study will help elucidate the role of IGF-1 in the regulation of muscle size under varying loading/activation conditions. ..
  66. Feasibility of assessing bone architecture by i-DQC MRI
    Felix Wehrli; Fiscal Year: 2006
    ..abstract_text> ..
    SHANNON BROWNING; Fiscal Year: 2007
    ..A nearly constant, forward propulsion assist force applied at the waist is optimal and allows for greater weight bearing and more natural gait...