tensile strength

Summary

Summary: The maximum stress a material subjected to a stretching load can withstand without tearing. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p2001)

Top Publications

  1. ncbi Flexural and diametral tensile strength of composite resins
    Alvaro Della Bona
    School of Dentistry, University of Passo Fundo, Passo Fundo, RS, Brazil
    Braz Oral Res 22:84-9. 2008
  2. ncbi Changes in the stiffness, strength, and toughness of human cortical bone with age
    P Zioupos
    Department of Biology, University of York, York, UK
    Bone 22:57-66. 1998
  3. ncbi Does a low-shrinking composite induce less stress at the adhesive interface?
    Annelies Van Ende
    Leuven BIOMAT Research Cluster, Department of Conservative Dentistry, School of Dentistry, Oral Pathology and Maxillo Facial Surgery, Catholic University of Leuven, Kapucijnenvoer 7, 3000 Leuven, Belgium
    Dent Mater 26:215-22. 2010
  4. ncbi Molecular and nanostructural mechanisms of deformation, strength and toughness of spider silk fibrils
    Andrea Nova
    Department of Civil and Environmental Engineering, Massachusetts Institute ofTechnology, Cambridge, Massachusetts 02139, USA
    Nano Lett 10:2626-34. 2010
  5. ncbi Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles
    Hazel R C Screen
    Medical Engineering Division and IRC in Biomedical Materials, Department of Engineering, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Biochem Biophys Res Commun 336:424-9. 2005
  6. ncbi The mechanical design of spider silks: from fibroin sequence to mechanical function
    J M Gosline
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    J Exp Biol 202:3295-303. 1999
  7. ncbi Hydroalcoholic extract based-ointment from Punica granatum L. peels with enhanced in vivo healing potential on dermal wounds
    E A Hayouni
    Laboratory of Bioactive Compounds at Biotechnology Center, Ecopark of Borj Cedria, BP 901, Hammam Lif 2050, Tunisia
    Phytomedicine 18:976-84. 2011
  8. pmc Systematic error in mechanical measures of damage during four-point bending fatigue of cortical bone
    Matthew D Landrigan
    Department of Aerospace and Mechanical Engineering, The University of Notre Dame, Notre Dame, IN 46556, USA
    J Biomech 42:1212-7. 2009
  9. ncbi Effect of proximal wall height on all-ceramic crown core stress distribution: a finite element analysis study
    Paulo G Coelho
    Department of Biomaterials and Biomimetics, New York University College of Dentistry, 345 24th Street, Room 804s, New York, NY 10010, USA
    Int J Prosthodont 22:78-86. 2009
  10. ncbi Nanoleakage, ultramorphological characteristics, and microtensile bond strengths of a new low-shrinkage composite to dentin after artificial aging
    Sillas Duarte
    Department of Comprehensive Care, Case Western Reserve University, School of Dental Medicine, 10900 Euclid Avenue, Cleveland, OH 44106 4905, USA
    Dent Mater 25:589-600. 2009

Detail Information

Publications317 found, 100 shown here

  1. ncbi Flexural and diametral tensile strength of composite resins
    Alvaro Della Bona
    School of Dentistry, University of Passo Fundo, Passo Fundo, RS, Brazil
    Braz Oral Res 22:84-9. 2008
    This study evaluated the flexural strength (sf) and the diametral tensile strength (st) of light-cured composite resins, testing the hypothesis that there is a positive relation between these properties...
  2. ncbi Changes in the stiffness, strength, and toughness of human cortical bone with age
    P Zioupos
    Department of Biology, University of York, York, UK
    Bone 22:57-66. 1998
    ..The macrocrack was preceded by less damage, and once created needed less energy to drive through the tissue (Wf)...
  3. ncbi Does a low-shrinking composite induce less stress at the adhesive interface?
    Annelies Van Ende
    Leuven BIOMAT Research Cluster, Department of Conservative Dentistry, School of Dentistry, Oral Pathology and Maxillo Facial Surgery, Catholic University of Leuven, Kapucijnenvoer 7, 3000 Leuven, Belgium
    Dent Mater 26:215-22. 2010
    ..Therefore, we investigated the effect of C-factor (flat surface vs. class-I cavity) and different composite application protocols on the bonding effectiveness of a low-shrinking composite to human dentin...
  4. ncbi Molecular and nanostructural mechanisms of deformation, strength and toughness of spider silk fibrils
    Andrea Nova
    Department of Civil and Environmental Engineering, Massachusetts Institute ofTechnology, Cambridge, Massachusetts 02139, USA
    Nano Lett 10:2626-34. 2010
    ..In particular, the ultimate tensile strength of silk is controlled by the strength of beta-sheet nanocrystals, which is directly related to their size, ..
  5. ncbi Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles
    Hazel R C Screen
    Medical Engineering Division and IRC in Biomedical Materials, Department of Engineering, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Biochem Biophys Res Commun 336:424-9. 2005
    ..These data provide evidence of altered anabolic activity within tendon in response to mechanical stimuli, and suggest the importance of cyclic tensile loading for the maintenance of the collagen hierarchy within tendon...
  6. ncbi The mechanical design of spider silks: from fibroin sequence to mechanical function
    J M Gosline
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    J Exp Biol 202:3295-303. 1999
    ....
  7. ncbi Hydroalcoholic extract based-ointment from Punica granatum L. peels with enhanced in vivo healing potential on dermal wounds
    E A Hayouni
    Laboratory of Bioactive Compounds at Biotechnology Center, Ecopark of Borj Cedria, BP 901, Hammam Lif 2050, Tunisia
    Phytomedicine 18:976-84. 2011
    ..the wound contraction and the period of epithelialization as assessed by the mechanical (contraction rate, tensile strength), the biochemical (increasing of collagen, DNA and proteins synthesis) and the histopathological ..
  8. pmc Systematic error in mechanical measures of damage during four-point bending fatigue of cortical bone
    Matthew D Landrigan
    Department of Aerospace and Mechanical Engineering, The University of Notre Dame, Notre Dame, IN 46556, USA
    J Biomech 42:1212-7. 2009
    ..The results of this study suggest that investigations of fatigue microdamage in cortical bone should avoid the use of four-point bending unless no other option is possible...
  9. ncbi Effect of proximal wall height on all-ceramic crown core stress distribution: a finite element analysis study
    Paulo G Coelho
    Department of Biomaterials and Biomimetics, New York University College of Dentistry, 345 24th Street, Room 804s, New York, NY 10010, USA
    Int J Prosthodont 22:78-86. 2009
    ....
  10. ncbi Nanoleakage, ultramorphological characteristics, and microtensile bond strengths of a new low-shrinkage composite to dentin after artificial aging
    Sillas Duarte
    Department of Comprehensive Care, Case Western Reserve University, School of Dental Medicine, 10900 Euclid Avenue, Cleveland, OH 44106 4905, USA
    Dent Mater 25:589-600. 2009
    ..The null hypotheses tested were (1) aging does not affect the bonding of low-shrinkage composite; (2) there is no difference in microtensile bond strengths and nanoleakage using different bonding strategies...
  11. pmc Fibronectin forms the most extensible biological fibers displaying switchable force-exposed cryptic binding sites
    Enrico Klotzsch
    Department of Materials, Eidgenossische Technische Hochschule Zurich, CH 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:18267-72. 2009
    ..Physiological implications of the extraordinary extensibility of Fn fibers and contraction kinetics are discussed...
  12. ncbi Mixed-mode failure strength of implant-cement interface specimens with varying surface roughness
    J Zelle
    Orthopaedic Research Laboratory, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Biomech 44:780-3. 2011
    ..The findings presented in this paper can be used in numerical models to simulate loosening at the implant-cement interface...
  13. ncbi Physicomechanical evaluation of polypropylene, polyester, and polytetrafluoroethylene meshes for inguinal hernia repair
    Corey R Deeken
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Coll Surg 212:68-79. 2011
    ..The objectives of this study were to propose standard techniques, perform physicomechanical testing, and classify materials commonly used for inguinal hernia repair...
  14. ncbi Development and analysis of a collagen-based hemostatic adhesive
    Seung Hyuk Baik
    Department of Medical Engineering, Yonsei University College of Medicine, Seoul, Korea
    J Surg Res 164:e221-8. 2010
    ..Commercially available hemostatic-adhesive has the risk of disease transmission because it is derived from a plasma component. The purpose of this study is to manufacture a new hemostatic adhesive and evaluate its performances...
  15. pmc Remarkable resilience of teeth
    Herzl Chai
    School of Mechanical Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Proc Natl Acad Sci U S A 106:7289-93. 2009
    ....
  16. ncbi The development of microcracking and failure in bone depends on the loading mode to which it is adapted
    G C Reilly
    Department of Biology, University of York, PO Box 373, York YO10 5YW, UK
    J Exp Biol 202:543-52. 1999
    ..The patterns of failure in the bone tissues of the two cortices are what would be expected assuming they were adapted to the mode of loading to which they are usually subjected...
  17. ncbi Differences in bonding to acid-etched or Er:YAG-laser-treated enamel and dentin surfaces
    A Martinez-Insua
    Santiago de Compostela University, Santiago de Compostela, Spain
    J Prosthet Dent 84:280-8. 2000
    ..It has been suggested that they are also useful for preparing dental surfaces for adhesion, but results to date have been controversial...
  18. ncbi Structural properties of fourth-generation composite femurs and tibias
    Anneliese D Heiner
    Biomechanics Laboratory, Department of Orthopaedics and Rehabilitation, University of Iowa, 2181 Westlawn, Iowa City, IA 52242, USA
    J Biomech 41:3282-4. 2008
    ..For the stiffness tests, variability between the specimens was less than 10% for all cases, and setup variability was less than 6%...
  19. ncbi Nanoscale heterogeneity promotes energy dissipation in bone
    Kuangshin Tai
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Nat Mater 6:454-62. 2007
    ..The fundamental concepts discovered here are applicable to a broad class of biological materials and may serve as a design consideration for biologically inspired materials technologies...
  20. pmc Hierarchical structure controls nanomechanical properties of vimentin intermediate filaments
    Zhao Qin
    Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 4:e7294. 2009
    ....
  21. pmc Mechanical properties of spider dragline silk: humidity, hysteresis, and relaxation
    T Vehoff
    Institute for X ray Physics, University of Gottingen, Gottingen, Germany
    Biophys J 93:4425-32. 2007
    ..In addition, this work also includes hysteresis as well as relaxation measurements. It is found that the relaxation process is well described by a stretched exponential decay...
  22. ncbi Comparison of mouse matrix metalloproteinase 13 expression in free-electron laser and scalpel incisions during wound healing
    Nanjun Wu
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2561, USA
    J Invest Dermatol 121:926-32. 2003
    ..the MMP-13 or the COL1A2 promoter driving luciferase expression, we observed MMP-13 and COL1A2 expression, tensile strength, macrophage infiltration, and wound histology for up to 62 d...
  23. ncbi Interrupted or continuous slowly absorbable sutures for closure of primary elective midline abdominal incisions: a multicenter randomized trial (INSECT: ISRCTN24023541)
    Christoph M Seiler
    Study Center of the German Surgical Society, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Ann Surg 249:576-82. 2009
    ..The aim of this study is to compare: (1) interrupted technique with rapidly absorbable sutures and (2) continuous techniques with different slowly absorbable sutures, focusing on the incidence of incisional hernias within 1 year...
  24. pmc Measurement of the toughness of bone: a tutorial with special reference to small animal studies
    R O Ritchie
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Bone 43:798-812. 2008
    ..Parallel experimental studies on wild-type rat and mouse femurs are used to evaluate the utility of these techniques and specifically to determine the coefficient of variation of the measured toughness values...
  25. ncbi Effect of a self-etch primer/adhesive on the shear bond strength of orthodontic brackets
    S E Bishara
    Department of Orthodontics, University of Iowa, College of Dentistry, Iowa City 52242-1001, USA
    Am J Orthod Dentofacial Orthop 119:621-4. 2001
    ..006) more residual adhesive remaining on the teeth that were treated with the new self-etch primer than on those teeth that were bonded with the use of the conventional adhesive system...
  26. ncbi Regenerative versus reparative healing in tendon: a study of biomechanical and histological properties in fetal sheep
    Pedro K Beredjiklian
    McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA
    Ann Biomed Eng 31:1143-52. 2003
    ..A better understanding of the mechanisms of fetal healing may lead to novel therapeutic strategies in the clinical setting...
  27. pmc Use of a specific MMP-inhibitor (galardin) for preservation of hybrid layer
    Lorenzo Breschi
    Department of Biomedicine, Unit of Dental Sciences and Biomaterials, University of Trieste, Trieste, Italy
    Dent Mater 26:571-8. 2010
    ..This study aimed to determine the contribution of a synthetic MMPs inhibitor (galardin) to the proteolytic activity of dentinal MMPs and to the morphological and mechanical features of hybrid layers after aging...
  28. ncbi Inhibition of enzymatic degradation of adhesive-dentin interfaces
    J De Munck
    Leuven BIOMAT Research Cluster, Department of Conservative Dentistry, School of Dentistry, Oral Pathology and Maxillo Facial Surgery, Catholic University of Leuven, Kapucijnenvoer 7, 3000 Leuven, Belgium
    J Dent Res 88:1101-6. 2009
    ..Water sorption of adhesive interfaces most likely remains the principal mechanism of bond degradation, while endogenous enzymes appear to contribute to bond degradation of only etch & rinse adhesives...
  29. ncbi Electrospun nano- to microfiber fabrics made of biodegradable copolyesters: structural characteristics, mechanical properties and cell adhesion potential
    Il Keun Kwon
    Department of Biomedical Engineering, Graduate School of Medicines, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka City, Fukuoka 812 8582, Japan
    Biomaterials 26:3929-39. 2005
    ..0 microm in diameter). The potential biomedical application of electrospun PLCL 50/50 was discussed...
  30. ncbi First investigation of spider silk as a braided microsurgical suture
    Joern W Kuhbier
    Department of Plastic, Hand, and Reconstructive Surgery, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Biomed Mater Res B Appl Biomater 97:381-7. 2011
    ..Morphologic appearance was studied and tensile strength and stress-strain ratio (SSR) were calculated...
  31. ncbi Efficacy of microtensile versus microshear bond testing for evaluation of bond strength of dental adhesive systems to enamel
    Ahmed A El Zohairy
    Department of Operative Dentistry, Faculty of Dentistry, University of Cairo, 1 Saraya El Manial St, Manial, Gizeh 11211, Cairo, Egypt
    Dent Mater 26:848-54. 2010
    ....
  32. ncbi Effect of C-factor on microtensile bond strengths of low-shrinkage composites
    N A El-Sahn
    Department of Operative Dentistry, Cairo University, Cairo, Egypt
    Oper Dent 36:281-92. 2011
    ..Filtek Z250/Adper Single Bond Plus (Z, 3M ESPE, St Paul, MN, USA) was used as a control...
  33. ncbi Nanoconfinement of spider silk fibrils begets superior strength, extensibility, and toughness
    Tristan Giesa
    Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 1 235A and B, Cambridge, Massachusetts 02139, United States
    Nano Lett 11:5038-46. 2011
    ..Our study reveals a general mechanism to map nanoscale properties to the macroscale and provides a potent design strategy toward novel fiber and bulk nanomaterials through hierarchical structures...
  34. ncbi Mathematical model to compare the relative tensile strength of the cornea after PRK, LASIK, and small incision lenticule extraction
    Dan Z Reinstein
    London Vision Clinic, London, UK
    J Refract Surg 29:454-60. 2013
    To develop a mathematical model to estimate the relative differences in postoperative stromal tensile strength following photorefractive keratectomy (PRK), LASIK, and small incision lenticule extraction (SMILE).
  35. ncbi Effects of blood contamination on microtensile bond strength to dentin of three self-etch adhesives
    Seok Woo Chang
    Department of Conservative Dentistry, The Institute of Oral Health Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Oper Dent 35:330-6. 2010
    ..05) groups. Based on the results of the current study, it was found that blood contamination reduced the MTBS of all three self-etch adhesives to dentin, and water-rinsing was unable to overcome the effects of blood contamination...
  36. ncbi Mechanical behaviour and rupture of normal and pathological human ascending aortic wall
    C M García-Herrera
    Departamento de Ingeniería Mecánica, Universidad de Santiago de Chile, USACH, Av Bernardo O Higgins 3363, Santiago de Chile, Chile
    Med Biol Eng Comput 50:559-66. 2012
    ..b>Tensile strength, stretch at failure and elbow stress were measured...
  37. ncbi Mechanical properties and remodeling of hybrid cardiac constructs made from heart cells, fibrin, and biodegradable, elastomeric knitted fabric
    Jan Boublik
    Division of Health Sciences and Technology, Center for Space Research, and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Tissue Eng 11:1122-32. 2005
    ..compared with native heart tissue, studied in vitro with respect to mechanical function (stiffness, ultimate tensile strength [UTS], failure strain epsilon(f), strain energy density E) and compositional remodeling (collagen, DNA), and ..
  38. pmc Down-regulation of POLYGALACTURONASE1 alters firmness, tensile strength and water loss in apple (Malus x domestica) fruit
    Ross G Atkinson
    The New Zealand Institute for Plant and Food Research Limited PFR, Mount Albert Research Centre, Private Bag 92169, Auckland 1142, New Zealand
    BMC Plant Biol 12:129. 2012
    ..This study examined the effect of down regulation of PG1 expression in 'Royal Gala' apples, a cultivar that typically has high levels of PG1, and softens during fruit ripening...
  39. ncbi Finite element analysis of stresses in endodontically treated, dowel-restored teeth
    Erik Asmussen
    Department of Dental Materials, Faculty of Health Sciences, School of Dentistry, University of Copenhagen, 20 Nørre Allé, DK 2200 Copenhagen N, Denmark
    J Prosthet Dent 94:321-9. 2005
    ..Endodontically-treated, dowel-restored teeth may experience fracture, but investigations of variables related to fracture are often inconclusive and occasionally contradictory...
  40. ncbi Tensegrity I. Cell structure and hierarchical systems biology
    Donald E Ingber
    Department of Surgery, Children s Hospital and Harvard Medical School, Enders 1007, 300 Longwood Avenue, Boston, MA 02115, USA
    J Cell Sci 116:1157-73. 2003
    ..Part II, which focuses on how these structural networks influence information processing networks, appears in the next issue...
  41. ncbi Aligned fibrous scaffolds for enhanced mechanoresponse and tenogenesis of mesenchymal stem cells
    Thomas K H Teh
    Department of Bioengineering, National University of Singapore, Singapore, Singapore
    Tissue Eng Part A 19:1360-72. 2013
    ..We thus propose that the aligned hybrid SF scaffold facilitates mechanoactivity and tenogenic differentiation of MSCs by intensifying the positive effects of mechanical stimulation in a 3D environment...
  42. ncbi Effect of aneurysm on the tensile strength and biomechanical behavior of the ascending thoracic aorta
    David A Vorp
    Department of Surgery and Bioengineering, University of Pittsburgh, McGowan Institute for Regenerative Medicine, Pittsburgh, Pennsylvania 15219, USA
    Ann Thorac Surg 75:1210-4. 2003
    ..The purpose of this study was to evaluate changes in biomechanical properties of the aortic wall related to ATAA formation...
  43. ncbi Nonlinear material behaviour of spider silk yields robust webs
    Steven W Cranford
    Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nature 482:72-6. 2012
    ..The superior performance of silk in webs is therefore not due merely to its exceptional ultimate strength and strain, but arises from the nonlinear response of silk threads to strain and their geometrical arrangement in a web...
  44. ncbi Prediction of mechanical properties of composites of HDPE/HA/EAA
    C Albano
    Universidad Central de Venezuela, Facultad de Ingenieria, Escuela de Ingeniería Química, Caracas, Venezuela
    J Mech Behav Biomed Mater 4:467-75. 2011
    ..Different mathematical models were used to predict their Young's modulus, tensile strength and elongation at break...
  45. ncbi High density polyethylene/graphite nano-composites for total hip joint replacements: processing and in vitro characterization
    H Fouad
    SABIC Polymer Research Center, King Saud University, Saudi Arabia
    J Mech Behav Biomed Mater 4:1376-83. 2011
    ..The prepared HDPE/GNPs composites appear to have fairly good comprehensive properties that make them a good candidate as a bearing material for the total joint replacement...
  46. ncbi Spider silk: from soluble protein to extraordinary fiber
    Markus Heim
    Lehrstuhl für Biomaterialien, Fakultät für Angewandte Naturwissenschaften, Universitat Bayreuth, 95440 Bayreuth, Germany
    Angew Chem Int Ed Engl 48:3584-96. 2009
    ....
  47. ncbi Synthetic nano-scale fibrous extracellular matrix
    P X Ma
    Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor 48109, USA
    J Biomed Mater Res 46:60-72. 1999
    ..The porosity decreased with polymer concentration. The mechanical properties (Young's modulus and tensile strength) increased with polymer concentration...
  48. ncbi Wet-spinning of recombinant silk-elastin-like protein polymer fibers with high tensile strength and high deformability
    Weiguo Qiu
    Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona 85721, USA
    Biomacromolecules 10:602-8. 2009
    ..Hydration dramatically influenced the mechanical behavior of SELP-47K fibers. In contrast to the high tensile strength and limited strains to failure of dry fibers, fully hydrated SELP-47K fibers possessed strains to failure as ..
  49. pmc Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing
    Evan B Katzel
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    J Orthop Res 29:684-93. 2011
    ..MTP) range of motion (ROM) was similar in Smad3(-/-) and wild-type (WT) mice while the basal tensile strength of Smad3(-/-) tendons was significantly (39%) lower than in WT controls...
  50. ncbi Anisotropic evaluation of synthetic surgical meshes
    E R Saberski
    University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Hernia 15:47-52. 2011
    ..Haphazard orientation of anisotropic mesh material can contribute to inconsistent surgical outcomes. We aimed to characterize and compare anisotropic properties of commonly used synthetic meshes...
  51. ncbi Comparing the behavior of different polypropylene meshes (heavy and lightweight) in an experimental model of ventral hernia repair
    J M Bellon
    Department of Surgery, Faculty of Medicine, Networking Research Center on Bioengineering, Biomaterials and Nanomedicine CIBER BBN, Alcala University, Alcala de Henares, Madrid, Spain
    J Biomed Mater Res B Appl Biomater 89:448-55. 2009
    ..After 14 days, the tensile strength of Optilene was greater than the strengths recorded for the other two biomaterials, probably because of its ..
  52. ncbi Diametral tensile strength and Vickers hardness of a composite after storage in different solutions
    Igor S Medeiros
    Department of Dental Materials, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil
    J Oral Sci 49:61-6. 2007
    This study evaluated the Vickers hardness (VHN) and diametral tensile strength (DTS) of the composite Z100 (3M ESPE) cured with: Quartz-Tungsten-Halogen light curing unit (QTH) (700mW/cm2- 40 s) and Argon laser (1,000mW/cm2- 10 s)...
  53. pmc The initiation of embryonic-like collagen fibrillogenesis by adult human tendon fibroblasts when cultured under tension
    Monika L Bayer
    Institute of Sports Medicine, Department of Orthopedic Surgery M, Bispebjerg Hospital, and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, 2400 Copenhagen, Denmark
    Biomaterials 31:4889-97. 2010
    ....
  54. ncbi In vitro effect of nanoleakage expression on resin-dentin bond strengths analyzed by microtensile bond test, SEM/EDX and TEM
    M Hashimoto
    Division of Pediatric Dentistry, Graduate School of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita ku, Sapporo, Hokkaido 060 8586, Japan
    Biomaterials 25:5565-74. 2004
    ..However, no correlation was found between the bond strengths and nanoleakage between the different adhesives (total-etch adhesive with different conditions or self-etch adhesives)...
  55. ncbi In vivo mechanical properties of thoracic aortic aneurysmal wall estimated from in vitro biaxial tensile test
    Tomohiro Fukui
    Graduate School of Mechanical Engineering, Tohoku University, Aramaki Aoba 01, Aoba ku, Sendai, Miyagi 980 8579, Japan
    Biomed Mater Eng 15:295-305. 2005
    ..This indicates the aneurysmal wall got more anisotropic in vivo as it becomes stiffer...
  56. ncbi Age-related change in the damage morphology of human cortical bone and its role in bone fragility
    Tamim Diab
    Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA
    Bone 38:427-31. 2006
    ..Age-related changes in damage morphology may therefore be an important contributor to the increased bone fragility in the elderly...
  57. ncbi Bone marrow-derived mesenchymal stromal cells accelerate wound healing in the rat
    Kellie McFarlin
    Department of Surgery, Henry Ford Health System, Detroit, Michigan, USA
    Wound Repair Regen 14:471-8. 2006
    ..The increase in the tensile strength of wounds treated with BMSCs was associated with increased production of collagen in the wound...
  58. ncbi Mechanical properties of dilated human ascending aorta
    Ruth J Okamoto
    Department of Mechanical Engineering, Washington University, St Louis, MO 63130 4899, USA
    Ann Biomed Eng 30:624-35. 2002
    ..35 +/- 0.37 MPa, n= 14) than younger (2.04 +/- 0.46 MPa, n = 11, age <50 years). These changes in mechanical properties suggest that age may influence the risk of aortic dissection or rupture of dilated ascending aorta...
  59. ncbi Novel biodegradable films and scaffolds of chitosan blended with poly(3-hydroxybutyrate)
    Wenling Cao
    Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China
    J Biomater Sci Polym Ed 16:1379-94. 2005
    ..a wet state, the blended films exhibited a lower elastic modulus, a higher elongation-at-break and a higher tensile strength compared with chitosan films...
  60. ncbi Durability of the resin bond strength to zirconia ceramic after using different surface conditioning methods
    Mona Wolfart
    Department of Prosthodontics, Propaedeutics and Dental Materials, Dental School, Christian Albrechts University at Kiel, Germany
    Dent Mater 23:45-50. 2007
    ..The purpose of this in vitro study was the evaluation of the bond strength and its durability of two composite resins to zirconia ceramic after using different surface conditioning methods...
  61. ncbi Mouse model of post-infarct ventricular rupture: time course, strain- and gender-dependency, tensile strength, and histopathology
    Xiao Ming Gao
    Experimental Cardiology Laboratory, Wynn Domain, Baker Medical Heart Research Institute and Alfred Heart Centre, Alfred Hospital, Commercial Road, P O Box 6492, Melbourne, Victoria 3004, Australia
    Cardiovasc Res 65:469-77. 2005
    ..We have examined the natural history, histopathology and myocardial mechanical strength in mice with AMI...
  62. ncbi Evaluation of varying amounts of thermal cycling on bond strength and permanent deformation of two resilient denture liners
    José Renato Ribeiro Pinto
    School of Dentistry, Paulista University, Sao Paulo, Brazil
    J Prosthet Dent 92:288-93. 2004
    ..Two problems found in prostheses with resilient liners are bond failure to the acrylic resin base and increased permanent deformation due to material aging...
  63. ncbi Water sorption, solubility, and tensile bond strength of resilient denture lining materials polymerized by different methods after thermal cycling
    Blanca Liliana Torres León
    Department of Prosthodontics and Periodontology, School of Dentistry of Piracicaba, University of Campinas, Sao Paulo, Brazil
    J Prosthet Dent 93:282-7. 2005
    ..The clinical properties of resilient denture lining materials may be influenced by the methods used to polymerize them...
  64. ncbi Incorporation of intact elastin scaffolds in tissue-engineered collagen-based vascular grafts
    Joseph D Berglund
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Tissue Eng 10:1526-35. 2004
    ..Future challenges include stimulating appropriate reorganization or synthesis of the collagen matrix to provide the necessary strength and viscoelastic properties for implantation...
  65. ncbi Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue
    Harun H Bayraktar
    Orthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, 2166 Etcheverry Hall, Berkeley, CA 94720 1740, USA
    J Biomech 37:27-35. 2004
    ....
  66. ncbi Anisotropy of tensile strength of root dentin
    V Lertchirakarn
    School of Dental Science, University of Melbourne, Australia
    J Dent Res 80:453-6. 2001
    ..We have tested the hypothesis that ultimate tensile strength (UTS) of dentin is affected by tubule (and hence collagen fibril) orientation...
  67. ncbi Microtensile bond strength and interfacial characterization of 11 contemporary adhesives bonded to bur-cut dentin
    Mouhamed Sarr
    Universite Cheikh Anta Diop, Faculte de Medecine, Pharmacie et Odontologie, Dakar, Senegal
    Oper Dent 35:94-104. 2010
    ..This study evaluated mechanically and ultra-morphologically 11 different adhesive systems bonded to dentin...
  68. ncbi Time dependence of cyclic tensile strain on collagen production in tendon fascicles
    Eijiro Maeda
    Medical Engineering Division and IRC in Biomedical Materials, School of Engineering and Material Science, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Biochem Biophys Res Commun 362:399-404. 2007
    ..These results indicate that collagen synthesis by tenocytes is controlled by a complex mechanosensitive process with a temporal component...
  69. ncbi Effect of wet vs. dry testing on the mechanical properties of hydrophilic self-etching primer polymers
    Keiichi Hosaka
    Cariology and Operative Dentistry, Department of Restorative Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Oral Sci 115:239-45. 2007
    ..The polymers were cast into small 'I' beams and light-cured. The modulus of elasticity (E) and ultimate tensile strength (UTS) were measured in dry polymers and after immersion in water for 24 h...
  70. ncbi Elastic and rupture properties of porcine aortic tissue measured using inflation testing
    Steven P Marra
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH, 03755 8000, USA
    Cardiovasc Eng 6:123-31. 2006
    ....
  71. ncbi Effect of thermocycling on bond strength and elasticity of 4 long-term soft denture liners
    José Renato Ribeiro Pinto
    School of Dentistry, Paulista University, Sao Paulo, Brazil
    J Prosthet Dent 88:516-21. 2002
    ..Two problems found in prostheses with soft liners are bond failure to the acrylic resin base and loss of elasticity due to material aging...
  72. pmc A flexible strain sensor based on a Conductive Polymer Composite for in situ measurement of parachute canopy deformation
    Cédric Cochrane
    University Lille Nord de France, F 59000 Lille, France
    Sensors (Basel) 10:8291-303. 2010
    ..Finally, our sensor was tested on a parachute canopy during a real drop test: the canopy fabric deformation during the critical inflation phase was successfully measured, and was found to be less than 9%...
  73. ncbi Human in vivo cellular response to a cross-linked acellular collagen implant
    T M Hammond
    Centre for Academic Surgery, Institute of Cellular and Molecular Science, The Royal London Hospital, Barts and The London NHS Trust, Queen Mary School of Medicine and Dentistry, University of London, London, UK
    Br J Surg 95:438-46. 2008
    ..The aim was to evaluate the human host response to an acellular porcine-derived cross-linked collagen implant...
  74. ncbi Novel dermo-epidermal equivalents on silk fibroin-based formic acid-crosslinked three-dimensional nonwoven devices with prospective applications in human tissue engineering/regeneration/repair
    Ilaria Dal Pra
    Histology and Embryology Unit, Department of Biomedical and Surgical Sciences, University of Verona Medical School, Verona, Italy
    Int J Mol Med 18:241-7. 2006
    ..The results of scanning electron microscopy, differential scanning calorimetry, and thermogravimetric and tensile strength studies showed that such scaffolds are made by a composite material, in which anisotropic SF fibres are ..
  75. ncbi Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: synthesis and in vitro evaluation
    Marta Roldo
    Institute of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Vienna, Austria
    Eur J Pharm Biopharm 57:115-21. 2004
    ..These results contribute to the development of new delivery systems exhibiting improved mucoadhesive properties...
  76. pmc Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytes
    Jeffrey G Jacot
    Department of Bioengineering, University of California, San Diego, USA
    Biophys J 95:3479-87. 2008
    ..On very stiff substrates, this adaptation seems to involve RhoA kinase...
  77. ncbi Osteogenic differentiation of human mesenchymal stem cells in collagen matrices: effect of uniaxial cyclic tensile strain on bone morphogenetic protein (BMP-2) mRNA expression
    Ruwan D Sumanasinghe
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695 7115, USA
    Tissue Eng 12:3459-65. 2006
    ..Induction of bone differentiation in 3D culture is a critical step in the creation of bioengineered bone constructs...
  78. ncbi Tooth morphology and characteristics of non-carious cervical lesions
    J E A Palamara
    School of Dental Science, The University of Melbourne, 711 Elizabeth Street, Melbourne, VIC 3000, Australia
    J Dent 34:185-94. 2006
    ..Two 3-dimensional models, one of a lower second premolar and one of a lower central incisor were used to investigate effects of load on the location and magnitude of cervical strains...
  79. ncbi Experimental evaluation of four biologic prostheses for ventral hernia repair
    Wolfgang B Gaertner
    Department of Surgery, University of Minnesota Medical School, 11 100 Phillips Wangensteen Bldg, 516 Delaware Street SE, Box 195, Minneapolis, MN 55455, USA
    J Gastrointest Surg 11:1275-85. 2007
    ..To evaluate two bioprostheses derived from bovine pericardium, one cross-linked (Peri-Guard) and the other non-cross-linked (Veritas), and to compare them with Alloderm and Permacol for abdominal wall repair...
  80. ncbi Activation of matrix metalloproteinase dilates and decreases cardiac tensile strength
    V S Mujumdar
    Department of Physiology and Biophysics, School of Medicine, The University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA
    Int J Cardiol 79:277-86. 2001
    ..overload hypertrophy to decompensatory volume overload heart failure is associated with decreased cardiac tensile strength and activation of matrix metalloproteinase (MMP) in spontaneously hypertensive rat (SHR)...
  81. ncbi Influence of root embedment material and periodontal ligament simulation on fracture resistance tests
    Carlos Jose Soares
    Department of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of Uberlandia
    Braz Oral Res 19:11-6. 2005
    ..05). The results showed that root embedment method and periodontal ligament simulation have a significant effect on fracture resistance. Artificial periodontal ligament modified the fracture modes...
  82. ncbi Hardness and diametral tensile strength of a hybrid composite resin polymerized with different modes and immersed in ethanol or distilled water media
    Flávio H B Aguiar
    Department of Restorative Dentistry, Piracicaba School of Dentistry, Campinas State University, Brazil
    Dent Mater 21:1098-103. 2005
    The aim of this in vitro study was to evaluate the microhardness and diametral tensile strength of a hybrid composite resin (Z250, 3M ESPE) polymerized with four different modes of light exposure and immersed in two different media.
  83. ncbi Mucoadhesive and cohesive properties of poly(acrylic acid)-cysteine conjugates with regard to their molecular mass
    V M Leitner
    Institute of Pharmaceutical Technology and Biopharmaceutics, Centre of Pharmacy, University of Vienna, Althanstr 14, A 1090, Vienna, Austria
    Eur J Pharm Sci 18:89-96. 2003
    ..The results of the present study contribute to the development of new polymers displaying further improved mucoadhesive properties...
  84. ncbi Platelet concentrate injection improves Achilles tendon repair in rats
    Per Aspenberg
    Orthopedics and Sports Medicine, Department of Neuroscience and Locomotion, Faculty of Health Science, SE 581 85 Linkoping, Sweden
    Acta Orthop Scand 75:93-9. 2004
    ..Blood platelets release a cocktail of growth factors when activated, some of which are thought to initiate and stimulate repair...
  85. ncbi Evaluation of diametral tensile strength and Knoop microhardness of five nanofilled composites in dentin and enamel shades
    Eduardo Goncalves Mota
    Pontifical Catholic University of Rio Grande do Sul, Brazil
    Stomatologija 8:67-9. 2006
    ..compare the mechanical behavior of five nanofilled composites with dentin and enamel shades trough diametral tensile strength and knoop microhardness...
  86. ncbi Minimum number of throws needed for knot security
    Tyler M Muffly
    Center for Urogynecology and Reconstructive Pelvic Surgery, Obstetrics, Gynecology and Women s Health Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Surg Educ 68:130-3. 2011
    ..The purpose of the study was to determine the optimal number of throws to ensure knot security...
  87. ncbi Experimental comparison of abdominal wall repair using different methods of enhancement by small intestinal submucosa graft
    Yves Ozog
    Center for Surgical Technologies, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Int Urogynecol J Pelvic Floor Dysfunct 20:435-41. 2009
    ..To assess the biomechanical properties of full-thickness abdominal wall defects, either using Native tissues, with or without Overlay, and by substitution of the Defect by small intestinal submucosa mesh...
  88. ncbi Lentiviral-based BMP4 in vivo gene transfer strategy increases pull-out tensile strength without an improvement in the osteointegration of the tendon graft in a rat model of biceps tenodesis
    Michael J Coen
    Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA
    J Gene Med 13:511-21. 2011
    ..The present study aimed to develop a rat model of biceps tenodesis and to assess the feasibility of a lentiviral (LV)-based bone morphogenetic protein (BMP) 4 in vivo gene transfer strategy for healing of biceps tenodesis...
  89. ncbi Impact of position of light mesh endoprosthesis with anisotropic structure for the efficiency of anterior abdominal wall reconstruction
    M V Anurov
    N I Pirogov Russian State Medical University, Moscow, Russia
    Bull Exp Biol Med 149:440-4. 2010
    ..However, the meshes were in some cases misshapen and formed folds across the loop columns, because of insufficient bending rigidity and elasticity of the material...
  90. ncbi 830-nm irradiation increases the wound tensile strength in a diabetic murine model
    I Stadler
    The Laser Center, Rochester General Hospital, Rochester, New York 14621, USA
    Lasers Surg Med 28:220-6. 2001
    ..The purpose of this study was to investigate the effects of low-power laser irradiation on wound healing in genetic diabetes...
  91. ncbi Tensile strength and corrosion resistance of brazed and laser-welded cobalt-chromium alloy joints
    Rok Zupancic
    Department of Prosthodontics, University of Ljubljana, Faculty of Medicine, Division of Dental Medicine, Slovenia
    J Prosthet Dent 96:273-82. 2006
    ..The longevity of prosthodontic restorations is often limited due to the mechanical or corrosive failure occurring at the sites where segments of a metal framework are joined together...
  92. doi Materials science. Bioinspired structural materials
    Christine Ortiz
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 319:1053-4. 2008
  93. ncbi Tensile strength of the supraspinatus after reimplantation into a bony trough: an experimental study in rabbits
    Hans K Uhthoff
    Bone and Joint Research Laboratory, University of Ottawa, Ottawa General Hospital, Smyth Road, Ontario K1H 8L6, Canada
    J Shoulder Elbow Surg 11:504-9. 2002
    ..After sacrifice at 8 and 12 weeks, tensile strength was measured...
  94. ncbi Use of a statistical model of the whole femur in a large scale, multi-model study of femoral neck fracture risk
    Rebecca Bryan
    Bioengineering Sciences Research Group, University of Southampton, Highfield, SO17 1BJ Southampton, UK
    J Biomech 42:2171-6. 2009
    ..The likely fracture location was indicated to be intertrochantic. Comparison to previous computational, clinical and experimental work revealed support for these findings...
  95. ncbi Various conditioning methods for root canals influencing the tensile strength of titanium posts
    P Schmage
    Department of Operative Dentistry and Periodontology, Dental School, University of Hamburg, Hamburg, Germany
    J Oral Rehabil 31:890-4. 2004
    ..The tensile strength values were measured with the universal testing machine at a crosshead speed of 0.5 mm min(-1)...
  96. ncbi Macroscopic fibers self-assembled from recombinant miniature spider silk proteins
    Margareta Stark
    Department of Anatomy, Physiology, and Biochemistry, The Biomedical Centre, Swedish University of Agricultural Sciences, SE 751 23 Uppsala, Sweden
    Biomacromolecules 8:1695-701. 2007
    ..These findings enable controlled production of high-performance biofibers at large scale under physiological conditions...
  97. ncbi In vitro technique in estimation of passive mechanical properties of bovine heart part I. Experimental techniques and data
    Hamid Ghaemi
    Department of Mechanical Engineering, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4L7
    Med Eng Phys 31:76-82. 2009
    ..After preconditioning, the samples were tested at various stretch rates and loading conditions. Finally, a conclusion is made on the experimental data...
  98. ncbi Creating a spectrum of fibrocartilages through different cell sources and biochemical stimuli
    Gwendolyn M Hoben
    Department of Bioengineering, Rice University, 6100 Main St, Keck Hall Suite 116, Houston, Texas 77005, USA
    Biotechnol Bioeng 100:587-98. 2008
    ..Fibrocartilages such as the knee meniscus are characterized by heterogeneity in matrix and functional properties, and this work demonstrates a strategy for recreating these heterogeneous tissues...
  99. ncbi Effect of peroxide-based bleaching agents on enamel ultimate tensile strength
    Alessandra Peres da Silva
    University of Campinas, Piracicaba School of Dentistry, Department of Restorative Dentistry, Piracicaba, Brazil
    Oper Dent 30:318-24. 2005
    This study evaluated the effects of peroxide bleaching regimens on the ultimate tensile strength (UTS) of human enamel...
  100. ncbi Mechanical evaluation of poly(vinyl alcohol)-based fibrous composites as biomaterials for meniscal tissue replacement
    Julianne L Holloway
    Dept of Chemical and Biological Engineering, Drexel University, Philadelphia, PA 19104, USA
    Acta Biomater 6:4716-24. 2010
    ..It is possible that the formation of regions with highly concentrated amounts of PVA increases the load-bearing ability of the hydrogels...
  101. ncbi Physicochemical characterisation of novel ultra-thin biodegradable scaffolds for peripheral nerve repair
    Mingzhu Sun
    Department of Engineering and Physical Sciences, Materials Science Centre, The University of Manchester, Manchester, UK
    J Mater Sci Mater Med 20:1181-92. 2009
    ..Average surface roughness (Ra), hydrophilicity/hydrophobicity and mechanical properties of these materials were also assessed for the suitability of these materials as nerve conduits...

Research Grants62

  1. Angiogenic tissue engineering to limit post-infarction ventricular remodeling
    Y Joseph Woo; Fiscal Year: 2012
    ..echocardiography and myocardial tissue properties will be studied utilizing atomic force microscopy and tensile strength measurements...
  2. Mesenchymal Stem Cells To Mitigate and Treat Cutaneous Injury Following Radiation
    William H McBride; Fiscal Year: 2010
    ..Quantitative assays of wound tensile strength showed that moderate doses of 4-7Gy to the whole body were equivalent to 15-20Gy to the skin...
  3. Novel Formulation of Topical Losartan for Treatment of Wounds in Aging
    JEREMY DAVID WALSTON; Fiscal Year: 2013
    ..mice through determining the difference in time to wound closure, through the comparison of healed tissue tensile strength, and through comparison of blood pressure, renal function, and mortality between treatment and placebo groups...
  4. Sex Hormones and Rat Anterior Cruciate Ligament Strength
    William A Romani; Fiscal Year: 2010
    ..In our first specific aim the tensile strength of the ACL will be tested to demonstrate that sex hormones mediate gender specific changes in the strength of ..
  5. A collagen wound dressing augmented with a proteoglycan mimic to enhance chronic
    Kate Stuart; Fiscal Year: 2013
    ..both endothelial cells and keratinocytes;and 3) decrease granulation tissue and visible scarring and increase tensile strength after incisional wounding in a rat model...
  6. Tear-Resistant and Elastic Tissue Adhesive for Craniofacial Applications
    SILVIA D LUEBBEN; Fiscal Year: 2012
    ..Unfortunately the low tensile strength of current tissue adhesives limits their use to small cuts and abrasions and sutures are still significantly ..
  7. Bone marrow-derived fibroblasts in skin wound healing
    Omaida C Velazquez; Fiscal Year: 2010
    ..are associated with impaired tissue level neovascularization, impaired keratinocyte function, reduced tensile strength, and higher infection rates...
  8. Development of Age-Appropriate Fast Disintegrating Pediatric Granules and Tablets
    MOJI ADEYEYE; Fiscal Year: 2009
    ..of the products will be evaluated techniques such as particle size distribution, flowability, compactibility, tensile strength and dissolution...
  9. A novel anti-scar peptide for cutaneous wound repair
    Chia Soo; Fiscal Year: 2013
    ..Primary outcome measures will include improved gross visual appearance without reduction in wound tensile strength. AIM 2 (Months 13-24): Perform F06-C40 systemic and local toxicology studies...
  10. ALPHA-V INTEGRINS AND ADENOVIRUS CELL ENTRY
    Glen R Nemerow; Fiscal Year: 2013
    ..Advanced imaging of adenovirus by atomic force microscopy will be employed to measure the tensile strength and mechanical properties of the viral capsid...
  11. Engineered Matrix Mimetics: Novel Therapies for Wound Repair
    Denise C Hocking; Fiscal Year: 2012
    ..FN matrix assembly also promotes collagen matrix deposition and increases tissue tensile strength. FN matrix assembly is normally rapidly up- regulated following tissue injury, while reduced FN matrix ..
  12. Mechanisms for Wound Healing with Ultrasound
    Denise C Hocking; Fiscal Year: 2012
    ..of ECM fibronectin fibrils, which in turn, affects cell function, ECM organization and stability, tissue tensile strength, and vascular perfusion...
  13. Engineered Biologics for Repair of Abdominal Wall Musculofascia
    Anshu B Mathur; Fiscal Year: 2013
    ..scaffolds will increase with decorin due to the induction of fibril formation and would result in higher tensile strength of the regenerated tissue characterized by seamless integration at the repair site such that the integrity of ..
  14. Mechanical Conditioning of Tissue Engineered Blood Vessels for Atherosclerosis
    Elaine Lee; Fiscal Year: 2012
    ..Mechanical testing using an Instron machine can measure for elasticity and tensile strength. PUBLIC HEALTH RELEVANCE: Atherosclerosis is the chronic inflammatory response that leads to plaque formation ..
  15. Transcriptional regulation of tendon differentiation and matrix formation
    Ronen Schweitzer; Fiscal Year: 2013
    ..fibrils in tendons is the single most significant factor that determines biomechanical properties and tensile strength of tendons...
  16. Pre-Clinical Evaluation of Novel Peptidoglycan for Prevention of Hypertrophic Sca
    John Paderi; Fiscal Year: 2010
    ..wound in a rat results in improved healing as determined by reduction in visible scar and improved wound tensile strength. Glytrix hypothesizes that introduction of collagen binding peptidoglycan into deep dermal wounds in a Red ..
  17. Comprehensive Evaluation of Prolapse Meshes by an Interdisciplinary Research Team
    Pamela A Moalli; Fiscal Year: 2013
    ..While this results in a repair with increased tensile strength, it occurs at the expense of tissue function with accelerated tissue contraction, decreased elasticity and ..
  18. EFFECTS OF GAMMA RADIATION ON BIOMEDICAL POLYMERS
    Cato Laurencin; Fiscal Year: 1990
    ..2) in determining radiation effects, studies have concentrated on macroscopic properties of materials such as tensile strength, but have not addressed more subtle chemical effects that may lead to an altered host response to the ..
  19. APPLICATION OF CLICK CHEMISTRY IN THE DEVELOPMENT OF NOVEL DENTAL ADHESIVES
    Yong Wang; Fiscal Year: 2010
    ..Innovative techniques, including FTIR and micro-Raman chemical imaging, tensile strength testing, etc will be utilized to thoroughly characterize how the newly designed monomer-based adhesives ..
  20. Multivalent Growth Factor Conjugates to Accelerate Wound Neovascularization in El
    WESLEY MICHAEL JACKSON; Fiscal Year: 2013
    ..The wound size will also be measured periodically until full closure has been achieved. The tensile strength of the repaired tissue will then be evaluated...
  21. VAPOR GROWN CARBON FIBERS FOR BIOMEDICAL APPLICATIONS
    THOMAS APPLE; Fiscal Year: 1993
    ..The goal of this research is to tailor or "fine-tune" the electrical and thermal conductivity, the tensile strength and the modulus and the surface properties through various doping, coating and annealing procedures to allow ..
  22. Early Metazoan Nano-collagens for Promotion of Wound Healing
    Angel Anne Yanagihara; Fiscal Year: 2013
    ..jellyfish stinging-cell collagens exhibit extraordinary biophysical properties that rival surgical steel in tensile strength. Discovery of a remarkably robust "nano-collagen" (~10 nanometer) peptide with self-assembling and platelet ..
  23. In Vitro-In Vivo Correlation of Ocular Implants
    Uday B Kompella; Fiscal Year: 2013
    ..We hypothesize that key physicochemical properties such as implant surface area, porosity, tensile strength, and polymer degradation (due to polymer procurement from different sources) can differ for Q1/Q2 implants, ..
  24. High Strength Bioresorbable PLA/CaP Composites
    Tongxin Wang; Fiscal Year: 2013
    ..g. 100 MPa as the target value of the tensile strength). Moreover, by additional optimizing a number of critical variables (e.g...
  25. GLASS TRANSITION TEMPERATURE AND WEAR OF DENTAL RESINS
    JAN STANNARD; Fiscal Year: 1993
    ..Mechanical properties of compressive strength, tensile strength and coefficient of friction of the copolymers will be measured at several temperatures relative to their Tg ..
  26. Amniotic Membrane versus Pericardium in Reducing Glaucoma Drainage Tube Exposure
    HOSAM EL SHEHA; Fiscal Year: 2013
    ..a 100%-owned subsidiary of TissueTech, Inc., could offer better tensile strength, be suitable for tectonic support, and have biological activities to promote cellular infiltration by the ..
  27. Investigating Tumor Growth Dynamics Using Multimodal Contrast Agents and Optical
    Alexander Wei; Fiscal Year: 2010
    ..the development of invasive carcinomas, in which cells undergo transformations from turgid states with high tensile strength to plastic and deformable states associated with migration and extravasation...
  28. Scalable Purification of Silk-Like Proteins from Transgenic Tobacco
    WILLIAM MARCOTTE; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): Spider silks are protein fibers that exhibit a remarkable combination of tensile strength, resilience, and elasticity...
  29. Designing Spider Silk Proteins as Novel Biomaterials
    Randolph Lewis; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Spider silk, which has been evolving for over 450 million years, has a tensile strength greater than steel and elasticity greater than nylon...
  30. MOLECULAR STUDIES OF CORNEAL TRANSPARENCY
    John Hassell; Fiscal Year: 2003
    The cornea provides transparency, refraction and tensile strength, properties necessary for vision. Most of these properties are due to the unique structure of the extracellular matrix of the stroma...
  31. Foreign Body Response as a Performance Metric for Implanted Scaffolds
    David W Grainger; Fiscal Year: 2013
    ..of overcoming other requisite aspects of device in vivo performance, including tissue specific properties: tensile strength, porosity and micro-architecture, and custom defect-specific device morphologies (macrostructure)...
  32. NOVEL CONCEPT FOR DEGRADATION OF ABSORBABLE POLYMERS
    Chih Chang Chu; Fiscal Year: 1990
    ..The ability to in situ/externally regulate the rate of tensile strength loss SAS would make SAS more suitable in demanding surgical conditions (orthopaedic, cardiovascular ..
  33. BIOLOGICAL ROLE OF LYSYL OXIDASE-2 IN MATRIX DEVELOPMENT
    Ian Hornstra; Fiscal Year: 1999
    ..Elastin and collagen are the major components of the extracellular matrix that impart elasticity and high tensile strength, respectively, to mammalian connective tissues...
  34. A new absorbable mesh for hernia repair
    David Martin; Fiscal Year: 2007
    ..the biocompatibility of the finished device; (4) develop methods to characterize the finished device for tensile strength, suture pullout strength, burst strength and tear resistance; (5) determine the degradation profile for the ..
  35. Laser-Activated Collagen Adhesives for Herniorrhaphy
    Barbara Soltz; Fiscal Year: 2006
    ..to evaluate a variety of solder and mesh configurations, tissue bonding strategies, comparison of acute tensile strength of bonded peritoneum and the assessment of mesh stability, tissue damage and the presence/type of adhesions ..
  36. NEW HOMEBOX GENES IN SCARLESS FETAL WOUND HEALING
    Corey Largman; Fiscal Year: 2001
    DESCRIPTION: (Adapted from the applicant's abstract) - Adult skin wounds normally heal with compromised tensile strength, loss of hair and gland structures, and possibly disfiguring scars...
  37. ALTERED MATRIX METALLOPROTEINASES IN HEART FAILURE
    JEANINE D ARMIENTO; Fiscal Year: 2002
    Collagens are the major extracellular matrix component of the heart. The ECM provides structural integrity and tensile strength to the myocardium critical to maintaining the alignment of myocytes and myofibrils, and the overall geometry ..
  38. Development of a TAVI Device with a Reduced Crossing Profile
    Todd N McAllister; Fiscal Year: 2013
    ..In Specific Aim #1, we will quantify the mechanical properties (ultimate tensile strength, Young's modulus, bending stiffness and suture holding strength) of several different TESA ..
  39. OXIDATIVE DAMAGE AND PREMATURE RUPTURE OF THE MEMBRANES
    James Woods; Fiscal Year: 2004
    ..enzymes, metalloproteinases (MMPS) and their tissue inhibitors (TIMPS), collagen breakdown, membrane tensile strength and collagen repair...
  40. A new absorbable mesh for hernia repair
    David Martin; Fiscal Year: 2004
    ..PHA4400 suitable for knitting into a hernia mesh; (3) prepare a monofilament knitted mesh of PHA4400 with a tensile strength comparable to commercial synthetic (polypropylene) hernia meshes; and (4) demonstrate that the in vivo ..
  41. Experimental Model For Pressure Ulcers In Human Skin: The Role of Aging and ECM
    Marjana Tomic Canic; Fiscal Year: 2009
    ..metalloproteinases (MMP)) and its signaling (integrins, FAK and MAPK);2) mechanical properties of the skin (tensile strength);3) cellular morphology/biology (proliferation, apoptosis, and growth factor/cytokine production) using ..
  42. WATER SORPTION OF GLASSY DENTAL POLYMERS
    Robert Kusy; Fiscal Year: 1990
    ..how the amount of water taken up affects mechanical propteries such as hardness, elastic modulus, and tensile strength. Water uptake will be varied by control of relative humidity...
  43. Design and Development of a resorbable Bone Adhesive
    Eric Beckman; Fiscal Year: 2007
    ..The candidate formulations developed under Specific Aim 1 will be tested for tensile strength, Young's modulus, and pore diameter...
  44. BIOMECHANICS OF LEUKOCYTE ADHESION MOLECULES
    Klaus Ley; Fiscal Year: 2002
    ..vary systematically with the shearing force exerted on the cell bound by the selectin (reactive compliance or tensile strength)...
  45. An all titanium transcutaneous access device (TAD) for peritoneal dialysis
    Robert Whalen; Fiscal Year: 2007
    ..which is encapsulated in a thin, collagenous tissue capsule whose attachment to the material exceeds the tensile strength of the tissue. These are characteristics that make the material uniquely suitable for this application...
  46. Amniotic Membrane Patch Graft to Cover Glaucoma Drainage Tube
    HOSAM EL SHEHA; Fiscal Year: 2009
    ..We further speculate that a thicker version of cryopreserved amniotic membrane (AM) could offer better tensile strength, suitable for tectonic support, and biologically active to promote cellular infiltration by the surrounding ..
  47. CARTILAGE FROM ANIMAL MODELS OF OA & JOINT DISUSE
    VAN MOW; Fiscal Year: 1990
    ..The biomechanical properties to be determined include: intrinsic tensile and compressive moduli, tensile strength, kinetic swelling properties (including the equilibrium Donnan osmotic pressure), permeability, and the ..
  48. Role of Fibromodulin in Scarless Repair
    Chia Soo; Fiscal Year: 2005
    ..The first part of aim 1 will examine the histologic phenotypes and functional characteristics (e. g., tensile strength) of the FM-null wounds relative to wildtype controls...
  49. OPTIMAL LASER FOR SMALL DIAMETER VASCULAR ANASTOMOSES
    Robert Kung; Fiscal Year: 1990
    ..9 micrometer laser in vivo for both acute and chronic vascular welds via measurements of the tensile strength of the laser anastomoses of various vessel diameter...
  50. BLOCKING INTIMAL HYPERPLASIA FOLLOWING VASCULAR TRAUMA
    Edith Tzeng; Fiscal Year: 2000
    ..expression and NO synthesis on vascular responses such as reedothelialization, vasomotor reactivity, and tensile strength. AIM I: To determine the molecular mechanisms by which nitric oxide inhibits intimal hyperlasia...
  51. NIR TUNABLE LASER TISSUE WELDING
    ROBERT ALFANO; Fiscal Year: 2007
    ..tissues as a result of welding, using Raman spectroscopy; polarized transmission (birefringence); histology; tensile strength analysis, and scanning and transmission electron microscopy; (3) Compare effects of laser pulse width (ps, fs ..
  52. Design and Development of Sprayable Surgical Adhesive
    Eric Beckman; Fiscal Year: 2007
    ..brief, the physical characteristics of the adhesive (such as viscosity, Young's modulus, cure time and tensile strength) must be engineered to produce an adhesive that can be delivered in small volumes by spray in an operating ..
  53. EXERCISE & ELECTRICAL STIMULATION IN LIGAMENT INJURIES
    Laurence Dahners; Fiscal Year: 1990
    ..The degree of exercise which produces the most beneficial effects on tensile strength and MCL laxity will be documented...
  54. SURFACE METALLIZATION OF POLYURETHANE: IMPROVED PACEMAKE
    Piran Sioshansi; Fiscal Year: 1991
    ..The final area of testing will concentrate on changes which are induced by the coating on the original properties of the leads, such as tensile strength and stiffness.
  55. Permanent Vasodilators for Improved Angioplasty
    F Franano; Fiscal Year: 2005
    ..with direct intramural treatment during angioplasty and to determine the effects of treatment on vessel tensile strength. Completion of the specific aims and-successful achievement of milestone criteria will allow the project to ..
  56. STRUCTURAL STUDIES OF COLLAGEN FIBRILS BY NMR
    RICHARD WITTEBORT; Fiscal Year: 2000
    ..Collagen provides the proteinaceous matrix for bone, it is the dominant material in and responsible for the tensile strength of tendons and it maintains the structural integrity of veins and arteries...
  57. Variation in Cytokine and MMP Genes and Risk of PPROM
    Pedro Ferrand; Fiscal Year: 2006
    ..of matrix metalloproteinases (MMPs) that degrade the extracellular matrix, which gives the membranes their tensile strength. We hypothesize that variation in pro-inflammatory cytokine and MMP genes contributes to the risk of PROM and ..
  58. Feasibility of assessing bone architecture by i-DQC MRI
    Felix Wehrli; Fiscal Year: 2006
    ..Bone - a composite biomaterial - has evolved so as to provide the compressive and tensile strength needed for weight-bearing and locomotion...
  59. MECHANISM UNDERLYING PREMATURE RUPTURE OF FETAL MEMBRANE
    MARK PLESSINGER; Fiscal Year: 2001
    ..In addition, use of a membrane dynamometer will measure tensile strength of the membrane after ROS exposure and when pretreated with antioxidants.
  60. ENHANCED DURABILITY OF BIOPROSTHETIC HEART VALVES
    Michael Sacks; Fiscal Year: 2004
    ..We have demonstrated for PBHV that cyclic fatigue induces loss of radial compliance, tensile strength, and flexural rigidity...
  61. DRUG TREATMENT OF VASCULAR SCLEROPROTEIN DEFECTS
    ROBERT BOUCEK; Fiscal Year: 1980
    The purpose of these investigations is to identify drugs that will increase tensile strength of arterial and valvular connective tissue in man...
  62. LOW FRICTION BACTERICIDAL SILVER COATED CATHETERS
    Piran Sioshansi; Fiscal Year: 1991
    ..In addition to lowering the friction, the coating will also significantly increase the tensile strength of the catheter and act as a bactericidal agent...