elasticity

Summary

Summary: Resistance and recovery from distortion of shape.

Top Publications

  1. ncbi Matrix elasticity directs stem cell lineage specification
    Adam J Engler
    Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, 19104, USA
    Cell 126:677-89. 2006
  2. ncbi Tissue cells feel and respond to the stiffness of their substrate
    Dennis E Discher
    School of Engineering and Applied Science and Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104 6315, USA
    Science 310:1139-43. 2005
  3. ncbi Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients
    S Laurent
    Department of Pharmacology and INSERM U 337, Broussais Hospital, Paris, France
    Hypertension 37:1236-41. 2001
  4. ncbi Prediction of cardiovascular events and all-cause mortality with brachial-ankle elasticity index: a systematic review and meta-analysis
    Charalambos Vlachopoulos
    Peripheral Vessels Unit, 1st Department of Cardiology, Athens Medical School, Hippokration Hospital, Athens, Greece
    Hypertension 60:556-62. 2012
  5. pmc Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments
    Adam J Engler
    School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 166:877-87. 2004
  6. ncbi Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 327 Fiske St, Holliston, MA 01746, USA
    Hypertension 43:1239-45. 2004
  7. ncbi Elastic behavior of cross-linked and bundled actin networks
    M L Gardel
    Department of Physics, Harvard University, Cambridge, MA 02138, USA
    Science 304:1301-5. 2004
  8. pmc Fibroblast adaptation and stiffness matching to soft elastic substrates
    Jerome Solon
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biophys J 93:4453-61. 2007
  9. pmc Measuring the stiffness of bacterial cells from growth rates in hydrogels of tunable elasticity
    Hannah H Tuson
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Mol Microbiol 84:874-91. 2012
  10. pmc Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence
    Jochen Guck
    Institute for Soft Matter Physics, Department of Physics and Geosciences, University of Leipzig, 04103 Leipzig, Germany
    Biophys J 88:3689-98. 2005

Detail Information

Publications383 found, 100 shown here

  1. ncbi Matrix elasticity directs stem cell lineage specification
    Adam J Engler
    Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, 19104, USA
    Cell 126:677-89. 2006
    ..cells (MSCs) are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity. Soft matrices that mimic brain are neurogenic, stiffer matrices that mimic muscle are myogenic, and ..
  2. ncbi Tissue cells feel and respond to the stiffness of their substrate
    Dennis E Discher
    School of Engineering and Applied Science and Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104 6315, USA
    Science 310:1139-43. 2005
    ..stiffness is just emerging with quantitative studies of cells adhering to gels (or to other cells) with which elasticity can be tuned to approximate that of tissues...
  3. ncbi Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients
    S Laurent
    Department of Pharmacology and INSERM U 337, Broussais Hospital, Paris, France
    Hypertension 37:1236-41. 2001
    ..This study provides the first direct evidence that aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with essential hypertension...
  4. ncbi Prediction of cardiovascular events and all-cause mortality with brachial-ankle elasticity index: a systematic review and meta-analysis
    Charalambos Vlachopoulos
    Peripheral Vessels Unit, 1st Department of Cardiology, Athens Medical School, Hippokration Hospital, Athens, Greece
    Hypertension 60:556-62. 2012
    Brachial-ankle elasticity index (baEI; also known as brachial-ankle pulse wave velocity) has been proposed as a surrogate end point for cardiovascular disease...
  5. pmc Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments
    Adam J Engler
    School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 166:877-87. 2004
    ..Here, myoblasts were cultured on collagen strips attached to glass or polymer gels of varied elasticity. Subsequent fusion into myotubes occurs independent of substrate flexibility...
  6. ncbi Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 327 Fiske St, Holliston, MA 01746, USA
    Hypertension 43:1239-45. 2004
    ..This phenomenon may facilitate forward transmission of potentially deleterious pressure pulsations into the periphery...
  7. ncbi Elastic behavior of cross-linked and bundled actin networks
    M L Gardel
    Department of Physics, Harvard University, Cambridge, MA 02138, USA
    Science 304:1301-5. 2004
    Networks of cross-linked and bundled actin filaments are ubiquitous in the cellular cytoskeleton, but their elasticity remains poorly understood...
  8. pmc Fibroblast adaptation and stiffness matching to soft elastic substrates
    Jerome Solon
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biophys J 93:4453-61. 2007
    ..cross-linking, active contraction of the cytoskeleton can also modulate stiffness by exploiting the nonlinear elasticity of semiflexible biopolymer networks...
  9. pmc Measuring the stiffness of bacterial cells from growth rates in hydrogels of tunable elasticity
    Hannah H Tuson
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Mol Microbiol 84:874-91. 2012
    ..Our technique therefore enables the rapid determination of how changes in genotype and biochemistry affect the mechanical properties of the bacterial envelope...
  10. pmc Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence
    Jochen Guck
    Institute for Soft Matter Physics, Department of Physics and Geosciences, University of Leipzig, 04103 Leipzig, Germany
    Biophys J 88:3689-98. 2005
    ..Here we examine this hypothesized link between function and elasticity, enabling the distinction between different cells, by using a microfluidic optical stretcher, a two-beam laser ..
  11. ncbi Bilayer thickness and membrane protein function: an energetic perspective
    Olaf S Andersen
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York 10021, USA
    Annu Rev Biophys Biomol Struct 36:107-30. 2007
    ..The lipid bilayer thus becomes an allosteric regulator of membrane function...
  12. pmc Viscoelastic properties of individual glial cells and neurons in the CNS
    Yun Bi Lu
    Department of Pharmacology, School of Medicine, Zhejiang University, Yan An Road 353, Hangzhou 310031, China
    Proc Natl Acad Sci U S A 103:17759-64. 2006
    ....
  13. pmc Substrate compliance versus ligand density in cell on gel responses
    Adam Engler
    School of Engineering and Applied Science, Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Biophys J 86:617-28. 2004
    ..Based on such results, we hypothesize a central structural role for the cytoskeleton in driving the membrane outward during spreading whereas adhesion reinforces the spreading...
  14. ncbi Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study
    Pierre Boutouyrie
    Department of Pharmacology and INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Hypertension 39:10-5. 2002
    ..This study provides the first direct evidence in a longitudinal study that aortic stiffness is an independent predictor of primary coronary events in patients with essential hypertension...
  15. ncbi Supersonic shear imaging: a new technique for soft tissue elasticity mapping
    Jeremy Bercoff
    Laboratoire Ondes et Acoustique, Ecole Superieure de Physique et de Chimie Industrielles, National French Center of Science, Universite Paris VII, 75005 Paris, France
    IEEE Trans Ultrason Ferroelectr Freq Control 51:396-409. 2004
    ..Using inversion algorithms, the shear elasticity of medium can be mapped quantitatively from this propagation movie...
  16. pmc Plasma sodium stiffens vascular endothelium and reduces nitric oxide release
    Hans Oberleithner
    Institute of Physiology II and Department of Internal Medicine D, University of Munster, 48149 Munster, Germany
    Proc Natl Acad Sci U S A 104:16281-6. 2007
    ..The results suggest that changes in plasma sodium concentration per se may affect endothelial function and thus control vascular tone...
  17. ncbi Clinical applications of arterial stiffness; definitions and reference values
    Michael F O'Rourke
    St Vincent s Hospital UNSW and St Vincent s Clinic, Sydney, Australia
    Am J Hypertens 15:426-44. 2002
    ..E. Safar and E.D. Frohlich...
  18. pmc Non-equilibration of hydrostatic pressure in blebbing cells
    Guillaume T Charras
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 435:365-9. 2005
    ..Motion of the fluid relative to the network generates spatially heterogeneous transients in the pressure field, and can be described in the framework of poroelasticity...
  19. pmc Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 1 Edgewater Dr, Suite 201A, Norwood, MA 02062, USA
    J Appl Physiol (1985) 105:1652-60. 2008
    ....
  20. pmc Animal cell hydraulics
    Guillaume T Charras
    London Centre for Nanotechnology, University College London, London WC1H 0AH, UK
    J Cell Sci 122:3233-41. 2009
    ..Our fluid-filled sponge model could provide a unified framework to understand a number of disparate observations in cell morphology and motility...
  21. pmc Salt dependence of the elasticity and overstretching transition of single DNA molecules
    Jay R Wenner
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Saint Paul, Minnesota 55108, USA
    Biophys J 82:3160-9. 2002
    As double-stranded DNA is stretched to its B-form contour length, models of polymer elasticity can describe the dramatic increase in measured force...
  22. ncbi The role of matrix stiffness in regulating cell behavior
    Rebecca G Wells
    Department of Medicine Gastroenterology, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Hepatology 47:1394-400. 2008
    ..Particular mention is made of data suggesting that cells of the liver are mechanosensitive, highlighting the potential importance of these findings in understanding the biology of normal and diseased liver...
  23. ncbi Comparative evaluation of strain-based and model-based modulus elastography
    Marvin M Doyley
    Department of Radiology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Ultrasound Med Biol 31:787-802. 2005
    ..Solving the inverse elasticity problem (IEP) should obviate these difficulties; however, this approach to elastography is often fraught with ..
  24. pmc Elasticity maps of living neurons measured by combined fluorescence and atomic force microscopy
    Elise Spedden
    Department of Physics and Astronomy, Tufts University, Medford, Massachusetts, USA
    Biophys J 103:868-77. 2012
    Detailed knowledge of mechanical parameters such as cell elasticity, stiffness of the growth substrate, or traction stresses generated during axonal extensions is essential for understanding the mechanisms that control neuronal growth...
  25. pmc Model-based elastography: a survey of approaches to the inverse elasticity problem
    M M Doyley
    University of Rochester, Department of Electrical and Computer Engineering, Hopeman Engineering Building 413, Box 270126, Rochester, NY 14627, USA
    Phys Med Biol 57:R35-73. 2012
    ....
  26. ncbi Researching into the cellular shape, volume and elasticity of mesenchymal stem cells, osteoblasts and osteosarcoma cells by atomic force microscopy
    Denitsa Docheva
    Experimental Surgery and Regenerative Medicine, Department of Surgery, Ludwig Maximilians University, Munich, Germany
    J Cell Mol Med 12:537-52. 2008
    ..stiffness on the three different substrates, while MG63 cells demonstrated the unique feature of increased elasticity on collagen I...
  27. ncbi Structural transitions and elasticity from torque measurements on DNA
    Zev Bryant
    Department of Molecular and Cell Biology, Department of Physics, Howard Hughes Medical Institute, University of California, Berkeley, California 94720, USA
    Nature 424:338-41. 2003
    ..direct determination of the molecule's mechanical properties, provided rigorous tests of theories of polymer elasticity, revealed unforeseen structural transitions induced by mechanical stresses, and established an experimental and ..
  28. pmc Probing the elasticity of DNA on short length scales by modeling supercoiling under tension
    Robert Schöpflin
    CC Bioinformatics, University of Applied Sciences Stralsund, Stralsund, Germany
    Biophys J 103:323-30. 2012
    ..Until now, no unambiguous verification of these models has been obtained because probing the elasticity of DNA on short length scales remains challenging...
  29. ncbi Effect of Chinese herbal medicine for calming Gan (肝) and suppressing hyperactive yang on arterial elasticity function and circadian rhythm of blood pressure in patients with essential hypertension
    Guang Wei Zhong
    Institute of Integrated Traditional and Western Medicine, Xiangya Hospital, Central South University, Changsha, China
    Chin J Integr Med 17:414-20. 2011
    ..the effect of Chinese herbal medicine for calming Gan (肝) and suppressing hyperactive yang (平肝潜阳, CGSHY) on arterial elasticity function and the circadian rhythm of blood pressure in patients with essential hypertension (EH).
  30. ncbi In vivo brain viscoelastic properties measured by magnetic resonance elastography
    Michael A Green
    Prince of Wales Medical Research Institute, UNSW, Sydney, Australia
    NMR Biomed 21:755-64. 2008
    ..1 kPa) to be significantly stiffer than white matter (2.7 kPa). The first in vivo loss modulus (G'') measurements show no significant difference between grey matter (2.5 kPa) and white matter (2.5 kPa)...
  31. pmc Roles of titin in the structure and elasticity of the sarcomere
    Larissa Tskhovrebova
    Institute for Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK
    J Biomed Biotechnol 2010:612482. 2010
    ..Here we review some recent titin data and discuss its implications for sarcomere architecture and elasticity.
  32. pmc Nanoindentation studies of full and empty viral capsids and the effects of capsid protein mutations on elasticity and strength
    J P Michel
    Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095 1569, USA
    Proc Natl Acad Sci U S A 103:6184-9. 2006
    ..These calculations capture the features of the reversible indentation region and allow Young's moduli and relative strengths to be estimated for the empty capsids...
  33. ncbi Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria
    S Suresh
    Department of Materials Science and Engineering, and Division of Bioengineering, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Acta Biomater 1:15-30. 2005
    ..Some general perspectives on connections among structure, single-cell mechanical properties and biological responses associated with pathogenic processes are also provided in the context of the two diseases considered in this work...
  34. pmc Force microscopy of nonadherent cells: a comparison of leukemia cell deformability
    Michael J Rosenbluth
    Department of Bioengineering, University of California Berkeley and University of California San Francisco University of California Berkeley Joint Graduate Group in Bioengineering, Berkeley, USA
    Biophys J 90:2994-3003. 2006
    ....
  35. pmc Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating
    Adam J Engler
    Molecular and Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Sci 121:3794-802. 2008
    ..isolated embryonic cardiomyocytes cultured on a series of flexible substrates show that matrices that mimic the elasticity of the developing myocardial microenvironment are optimal for transmitting contractile work to the matrix and ..
  36. ncbi The mechanical design of spider silks: from fibroin sequence to mechanical function
    J M Gosline
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    J Exp Biol 202:3295-303. 1999
    ....
  37. ncbi Elasticity of spider silks
    Yi Liu
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
    Biomacromolecules 9:1782-6. 2008
    The elasticity of spider MAA silks containing varying proline content was investigated and compared with that of silkworm ( Bombyx mori) silk...
  38. ncbi Experimental validation of a time-domain-based wave propagation model of blood flow in viscoelastic vessels
    David Bessems
    Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600 MB Eindhoven, The Netherlands
    J Biomech 41:284-91. 2008
    ....
  39. pmc Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol
    Jens A Lundbaek
    Novo Nordisk A S, Måløv, Denmark
    J Gen Physiol 123:599-621. 2004
    ..The energetics and kinetics of the protein conformational changes therefore will be regulated by the bilayer elasticity, which is determined by the lipid composition...
  40. pmc Oxidative stress is associated with impaired arterial elasticity
    Riyaz S Patel
    Emory University School of Medicine, Atlanta, GA, USA
    Atherosclerosis 218:90-5. 2011
    ..The underlying mechanisms influencing arterial elasticity may involve oxidative injury to the vessel wall...
  41. pmc Cell-cycle control by physiological matrix elasticity and in vivo tissue stiffening
    Eric A Klein
    Department of Pharmacology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Biol 19:1511-8. 2009
    ..determine which of these pathways control mitogenesis in response to physiologically relevant changes in tissue elasticity. In this report, we use hydrogel-based substrata matched to biological tissue stiffness to investigate the ..
  42. ncbi Circulating level of microparticles and their correlation with arterial elasticity and endothelium-dependent dilation in patients with type 2 diabetes mellitus
    Bo Feng
    Department of Endocrinology, East Hospital, Tongji University, 150 Jimo Road, Shanghai, China
    Atherosclerosis 208:264-9. 2010
    ..study was designed to measure the circulating level of microparticles (MP) in patients with type 2 diabetes mellitus versus healthy volunteers and to evaluate their correlation with arterial elasticity and endothelium-dependent dilation.
  43. pmc Neutrophil morphology and migration are affected by substrate elasticity
    Patrick W Oakes
    Department of Physics, Brown University, Providence, RI, USA
    Blood 114:1387-95. 2009
    ..Using polyacrylamide gels of physiologically relevant elasticity in the range of 5 to 100 kPa and coated with fibronectin, we tested how neutrophil adhesion, spreading, and ..
  44. pmc The optical stretcher: a novel laser tool to micromanipulate cells
    J Guck
    Center for Nonlinear Dynamics, Department of Physics, University of Texas at Austin, Texas 78712, USA
    Biophys J 81:767-84. 2001
    ..The magnitude of the deforming forces in the optical stretcher thus bridges the gap between optical tweezers and atomic force microscopy for the study of biologic materials...
  45. ncbi Nonlinear elasticity and an 8-nm working stroke of single myosin molecules in myofilaments
    Motoshi Kaya
    Department of Physics, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyou ku, Tokyo, 113 0033 Japan
    Science 329:686-9. 2010
    ..Taking account of the nonlinear nature of myosin elasticity is essential to relate myosin's internal structural changes to physiological force generation and filament ..
  46. ncbi Nitric oxide regulates local arterial distensibility in vivo
    Ian B Wilkinson
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Circulation 105:213-7. 2002
    ..We hypothesized that nitric oxide (NO) acting locally regulates arterial stiffness in vivo, and the aim of this experiment was to test this hypothesis in an ovine hind-limb preparation...
  47. ncbi Aortic stiffness is an independent predictor of fatal stroke in essential hypertension
    Stephane Laurent
    Department of Pharmacology and INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Stroke 34:1203-6. 2003
    ..The influence of arterial stiffness on the occurrence of stroke has never been demonstrated. Our aim was to establish the relationship between aortic stiffness and stroke death in hypertensive patients...
  48. pmc The folding and stability of titin immunoglobulin-like modules, with implications for the mechanism of elasticity
    A S Politou
    European Molecular Biology Laboratory, Heidelberg, Germany
    Biophys J 69:2601-10. 1995
    ....
  49. ncbi Magnetic resonance elastography: non-invasive mapping of tissue elasticity
    A Manduca
    Mayo Clinic and Foundation, 200 1st St SW, Rochester, MN 55901, USA
    Med Image Anal 5:237-54. 2001
    ..the calculation of local quantitative values of shear modulus and the generation of images that depict tissue elasticity or stiffness...
  50. pmc Actin filament length tunes elasticity of flexibly cross-linked actin networks
    K E Kasza
    School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA
    Biophys J 99:1091-100. 2010
    ..We demonstrate that the elasticity of these networks shows a strong dependence on the mean length of the actin polymers, unlike networks with small,..
  51. ncbi Atomic force microscopy probing of cell elasticity
    Tatyana G Kuznetsova
    Gomel State Medical University, 5, Lange str, Gomel 246000, Belarus
    Micron 38:824-33. 2007
    ..Local mechanical characteristics of different cell types including muscle cells, endothelial and epithelial cells, neurons and glial cells, fibroblasts and osteoblasts, blood cells and sensory cells are analyzed in this paper...
  52. pmc Underwound DNA under tension: structure, elasticity, and sequence-dependent behaviors
    Maxim Y Sheinin
    Department of Physics, Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA
    Phys Rev Lett 107:108102. 2011
    ..We have also discovered that at low forces melted DNA properties are highly dependent on DNA sequence. These results provide a more comprehensive picture of the global DNA force-torque phase diagram...
  53. pmc Malleability of the folding mechanism of the outer membrane protein PagP: parallel pathways and the effect of membrane elasticity
    Gerard H M Huysmans
    Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    J Mol Biol 416:453-64. 2012
    ..The results highlight the effect of lipid composition in tailoring the folding mechanism of a membrane protein, revealing that membrane proteins have access to multiple, competing folding routes to a unique native structure...
  54. ncbi Physical aspects of cell culture substrates: topography, roughness, and elasticity
    Aftin M Ross
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    Small 8:336-55. 2012
    ..Physical cues such as topography, roughness, gradients, and elasticity are of particular importance...
  55. pmc A mechanical model of actin stress fiber formation and substrate elasticity sensing in adherent cells
    Sam Walcott
    Mechanical Engineering and Johns Hopkins Physical Science Oncology Center, Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 107:7757-62. 2010
    ..As these large bundles of actin, called stress fibers, appear preferentially on stiff surfaces, our mechanical model provides a mechanism for stress fiber formation and stiffness sensing in cells adhered to a compliant surface...
  56. ncbi Experimental validation of atomic force microscopy-based cell elasticity measurements
    Andrew R Harris
    London Centre for Nanotechnology, University College London, London WC1H 0AH, UK
    Nanotechnology 22:345102. 2011
    Atomic force microscopy (AFM) is widely used for measuring the elasticity of living cells yielding values ranging from 100 Pa to 100 kPa, much larger than those obtained using bead-tracking microrheology or micropipette aspiration (100-..
  57. ncbi Compliant model of a coupled sequential coronary arterial bypass graft: effects of vessel wall elasticity and non-Newtonian rheology on blood flow regime and hemodynamic parameters distribution
    Foad Kabinejadian
    School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
    Med Eng Phys 34:860-72. 2012
    ..Hence, the inclusion of wall compliance and non-Newtonian rheology in flow simulation of blood vessels can be essential in quantitative and comparative investigations...
  58. pmc Docosahexaenoic acid alters bilayer elastic properties
    Michael J Bruno
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:9638-43. 2007
    ..change in lipid intrinsic curvature and, like other reversibly adsorbing amphiphiles, increase bilayer elasticity. PUFA adsorption thus would alter the bilayer deformation energy associated with protein conformational changes ..
  59. pmc Elasticity and wrinkled morphology of Bacillus subtilis pellicles
    Miguel Trejo
    Laboratoire de Physique des Solides, Universite Paris Sud, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8502, F 91405 Orsay, France
    Proc Natl Acad Sci U S A 110:2011-6. 2013
    ..Finally, the experiments performed on a mutant strain indicate that the presence of an extracellular matrix is required to maintain a connective and elastic pellicle...
  60. ncbi Nonequilibrium mechanics of active cytoskeletal networks
    Daisuke Mizuno
    Department of Physics and Astronomy, Vrije Universiteit, 1081HV Amsterdam, Netherlands
    Science 315:370-3. 2007
    ..We present a quantitative theoretical model connecting the large-scale properties of this active gel to molecular force generation...
  61. ncbi Shear wave elasticity imaging: a new ultrasonic technology of medical diagnostics
    A P Sarvazyan
    Artann Laboratories, East Brunswick, NJ, USA
    Ultrasound Med Biol 24:1419-35. 1998
    Shear wave elasticity imaging (SWEI) is a new approach to imaging and characterizing tissue structures based on the use of shear acoustic waves remotely induced by the radiation force of a focused ultrasonic beam...
  62. pmc Real-time monitoring of cell elasticity reveals oscillating myosin activity
    Hermann Schillers
    Institute of Physiology II, University of Munster, Munster, Germany
    Biophys J 99:3639-46. 2010
    ..The cytoskeleton determines the mechanical properties of a cell. Thus, cell elasticity could serve as a parameter reflecting the behavior of the system rather than reflecting the specific properties ..
  63. ncbi Substrate stiffness affects early differentiation events in embryonic stem cells
    Nicholas D Evans
    Department of Materials, Imperial College London, London, UK
    Eur Cell Mater 18:1-13; discussion 13-4. 2009
    ....
  64. pmc In situ elasticity modulation with dynamic substrates to direct cell phenotype
    April M Kloxin
    Department of Chemical and Biological Engineering, University of Colorado, 424 UCB, ECCH 111, Boulder, CO 80309 USA
    Biomaterials 31:1-8. 2010
    Microenvironment elasticity influences critical cell functions such as differentiation, cytoskeletal organization, and process extension...
  65. ncbi Chondrocyte redifferentiation in 3D: the effect of adhesion site density and substrate elasticity
    Elena Schuh
    Institute for Biomechanics, ETH Zurich, Zurich, Switzerland
    J Biomed Mater Res A 100:38-47. 2012
    ..We hypothesize that the properties of this 3D environment, namely adhesion site density and substrate elasticity, would influence this redifferentiation process...
  66. ncbi Correlations between corneal hysteresis, intraocular pressure, and corneal central pachymetry
    David Touboul
    Department of Ophthalmology, Bordeaux 2 University, CHU Pellegrin, Place Amelie Raba Leon, Bordeaux, France
    J Cataract Refract Surg 34:616-22. 2008
    ....
  67. pmc Use the force: membrane tension as an organizer of cell shape and motility
    Alba Diz-Muñoz
    Bioengineering Department and Biophysics Program, University of California, Berkeley, CA 94720, USA
    Trends Cell Biol 23:47-53. 2013
    ..Here we review current understanding of how changes in PM tension regulate cell shape and movement, as well as how cells sense PM tension...
  68. ncbi Quantitative changes in the elasticity and adhesive properties of Escherichia coli ZK1056 prey cells during predation by bdellovibrio bacteriovorus 109J
    Catherine B Volle
    Department of Chemistry, Mount Holyoke College, South Hadley, Massachusetts 01075, USA
    Langmuir 24:8102-10. 2008
    ..In this work, we probe the elasticity and adhesive properties of uninvaded prey cells and bdelloplasts in a completely native state in dilute aqueous ..
  69. pmc The influence of scaffold elasticity on germ layer specification of human embryonic stem cells
    Janet Zoldan
    H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
    Biomaterials 32:9612-21. 2011
    ..The overall results suggest that three dimensional (3D) scaffolds can recapitulate the mechanical stimuli required for directing hESC differentiation and that these stimuli can play a significant role in determining hESC fate...
  70. ncbi Reliability, validity, and responsiveness of myotonometric measurement of muscle tone, elasticity, and stiffness in patients with stroke
    Li Ling Chuang
    School of Occupational Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan
    Arch Phys Med Rehabil 93:532-40. 2012
    ..To assess the metric properties of a myotonometer...
  71. ncbi A novel liver stiffness measurement-based prediction model for cirrhosis in hepatitis B patients
    Beom Kyung Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Liver Int 30:1073-81. 2010
    ..We developed a new LSM-based prediction model for cirrhosis and estimated the thresholds for different ALT levels...
  72. ncbi Elasticity-dependent modulation of TGF-β responses in human trabecular meshwork cells
    Hong Han
    Department of Ophthalmology, Würzburg University Hospital, Wurzburg, Germany
    Invest Ophthalmol Vis Sci 52:2889-96. 2011
    To gain further insight into a possible role of biomechanical cues in glaucoma, the authors assessed the influence of extracellular matrix (ECM) elasticity on TGF-β2-induced changes in trabecular meshwork (TM) cells.
  73. pmc Measuring the viscoelastic properties of human platelets with the atomic force microscope
    M Radmacher
    Department of Physics, University of California, Santa Barbara 93106, USA
    Biophys J 70:556-67. 1996
    ..The elastic moduli were in a range of 1-50 kPa measured in the frequency range of 1-50 Hz. Loading forces could be controlled with a resolution of 80 pN and indentations of the platelet could be determined with a resolution of 20 nm...
  74. ncbi Maladaptive aortic properties in children after palliation of hypoplastic left heart syndrome assessed by cardiovascular magnetic resonance imaging
    Inga Voges
    Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig Holstein, Kiel, Germany
    Circulation 122:1068-76. 2010
    ..Therefore, we assessed the anatomy, elastic properties, and viability of the aorta and right ventricular function in patients with hypoplastic left heart syndrome by cardiovascular magnetic resonance imaging...
  75. ncbi Apparent elastic modulus and hysteresis of skeletal muscle cells throughout differentiation
    Amy M Collinsworth
    Department of Biomedical Engineering, 136 Hudson Hall, Duke University, Durham, NC 27708, USA
    Am J Physiol Cell Physiol 283:C1219-27. 2002
    ..Major contributors to changes in the transverse elastic modulus during differentiation were actin and myosin...
  76. pmc Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes
    Eric M Darling
    Department of Surgery, Duke University Medical Center Durham, NC 27710, USA
    J Biomech 41:454-64. 2008
    ..Furthermore, the identification of mechanical properties distinct to stem cells could result in more successful sorting procedures to enrich multipotent progenitor cell populations...
  77. ncbi Regional variation in the biomechanical properties of the human sclera
    Ahmed Elsheikh
    Division of Civil Engineering, University of Dundee, Nethergate, Dundee, Tayside DD1 4HN, UK
    Exp Eye Res 90:624-33. 2010
    ..The considerable variation in biomechanical behaviour found in this study should be useful in improving the accuracy of representing the sclera's real-life conditions in numerical simulations...
  78. ncbi PEGDA hydrogels with patterned elasticity: Novel tools for the study of cell response to substrate rigidity
    Stephanie Nemir
    Department of Bioengineering, Rice University, Houston, Texas, USA
    Biotechnol Bioeng 105:636-44. 2010
    ..These hydrogels may be used to study cell response to substrate rigidity in both two and three dimensions and can also be used as a scaffold in tissue-engineering applications...
  79. ncbi [Realtime elastography. A new ultrasound procedure for the reconstruction of tissue elasticity]
    H Frey
    HITACHI Medical Systems GmbH, Wiesbaden
    Radiologe 43:850-5. 2003
    It is well known that some diseases, such as cancer, lead to a change of tissue hardness (i.e. the so-called elasticity modulus)...
  80. pmc Elasticity changes anti-correlate with NO production for human endothelial cells stimulated with TNF-α
    Agnieszka M Szczygiel
    Department of Physics of Nanostructures and Nanotechnology, Jagiellonian University, Reymonta 4, 30 059, Krakow, Poland
    Pflugers Arch 463:487-96. 2012
    ..In the present study, effects of TNF-α on morphology and elasticity of endothelium in relation to the production of NO and actin fiber reorganization were analyzed in human dermal ..
  81. ncbi Liver stiffness decrease after effective antiviral therapy in patients with chronic hepatitis C: Longitudinal study using FibroScan
    Jing Houng Wang
    Division of Hepato Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan
    J Gastroenterol Hepatol 25:964-9. 2010
    ..The aim of the present study was to assess the changes of liver stiffness (LS) and its associated factors in patients with chronic hepatitis C virus infection (HCV) after interferon (IFN)-based therapy...
  82. ncbi Structural disorder and protein elasticity
    Sarah Rauscher
    Molecular Structure and Function, Hospital for Sick Children, Toronto, Canada
    Adv Exp Med Biol 725:159-83. 2012
    An emerging class of disordered proteins underlies the elasticity of many biological tissues...
  83. ncbi Imaging and estimation of tissue elasticity by ultrasound
    Brian Stephen Garra
    Department of Radiology, University of Vermont College of Medicine, Fletcher Allen Health Care, Burlington, VT 05401, USA
    Ultrasound Q 23:255-68. 2007
    Ultrasound (US) elasticity imaging is an extension of the ancient art of palpation and of earlier US methods for viewing tissue stiffness such as echopalpation...
  84. pmc Extracellular matrix mechanics in lung parenchymal diseases
    Bela Suki
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Respir Physiol Neurobiol 163:33-43. 2008
    ..Finally, we speculate about the possibility of using targeted tissue engineering to optimize treatment of these two major lung diseases...
  85. ncbi Elasticity size effects in ZnO nanowires--a combined experimental-computational approach
    Ravi Agrawal
    Department of Mechanical Engineering, 2145 Sheridan Road, Northwestern University, Evanston, Illinois 60208 3111, USA
    Nano Lett 8:3668-74. 2008
    ..The computational results demonstrate similar size dependence, complementing the experimental findings, and reveal that the observed size effect is an outcome of surface reconstruction together with long-range ionic interactions...
  86. ncbi Mild-to-moderate elevation of alanine aminotransferase increases liver stiffness measurement by transient elastography in patients with chronic hepatitis B
    James Fung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR
    Am J Gastroenterol 106:492-6. 2011
    ..The present study aimed to investigate the effect of mild-to-moderate elevations of alanine aminotransferase (ALT) on liver stiffness in chronic hepatitis B...
  87. ncbi Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium
    Sunshine Lahmers
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Wash 99164, USA
    Circ Res 94:505-13. 2004
    ..Changes in titin expression are likely to impact functional transitions and diastolic filling behavior during development of the heart...
  88. pmc Reduced ascending aortic strain and distensibility: earliest manifestations of vascular aging in humans
    Alban Redheuil
    Division of Cardiology, Johns Hopkins University, Baltimore, MD 21287, USA
    Hypertension 55:319-26. 2010
    ..In particular, compared with other measures of aortic function, the best markers of subclinical large artery stiffening, were AA distensibility in younger and aortic arch pulse wave velocity in older individuals...
  89. pmc Elasticity and stress relaxation of rhesus monkey (Macaca mulatta) vocal folds
    Tobias Riede
    Department of Biology and National Center for Voice and Speech, University of Utah, Salt Lake City, UT 84112, USA
    J Exp Biol 213:2924-32. 2010
    ..A differentiated recruitment of tissue into oscillation could extend the frequency range specifically at the upper end of the frequency scale...
  90. pmc Modulation of titin-based stiffness by disulfide bonding in the cardiac titin N2-B unique sequence
    Anika Grützner
    Physiology and Biophysics Unit, University of Munster, Munster, Germany
    Biophys J 97:825-34. 2009
    The giant protein titin is responsible for the elasticity of nonactivated muscle sarcomeres...
  91. pmc Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma
    Sukhvinder S Sidhu
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 107:14170-5. 2010
    ..Epithelial cell-derived periostin in asthma has roles in TGF-beta activation and collagen gel elasticity in asthma.
  92. ncbi Correlation between brachial-ankle pulse wave velocity and arterial compliance and cardiovascular risk factors in elderly patients with arteriosclerosis
    Baoying Li
    Department of Geriatrics, Qi Lu Hospital of Shandong University, Jinan, PR China
    Hypertens Res 29:309-14. 2006
    ..444, p < 0.001), and between baPWV and C2 (r = -0.257, p < 0.01). In conclusion, these findings underscore the efficacy of baPWV and ABI in identifying the vascular damage of the aged...
  93. ncbi Cross-linking molecules modify composite actin networks independently
    K M Schmoller
    Lehrstuhl für Biophysik E27, Technische Universitat Munchen, James Franck Strasse 1, 85748 Garching, Germany
    Phys Rev Lett 101:118102. 2008
    ..The outnumbering ABP dictates the local network structure and therefore also dominates the macromechanical network response...
  94. ncbi Calcification of medial elastic fibers and aortic elasticity
    N Niederhoffer
    Laboratoire de Pharmacologie Cardio vasculaire, Faculté de Pharmacie de l Université Henri Poincaré, Nancy, France
    Hypertension 29:999-1006. 1997
    ..that a simple change in wall composition (medial calcium overload of elastic fibers) can decrease aortic elasticity. Calcium overload was produced by hypervitaminosis D plus nicotine (VDN) in the young rat...
  95. ncbi Protein modulation of lipids, and vice-versa, in membranes
    Derek Marsh
    Max Planck Institut fur biophysikalische Chemie, Abt Spektroskopie, Gottingen, Germany
    Biochim Biophys Acta 1778:1545-75. 2008
    ....
  96. ncbi Nanoindentation hardness of mineralized tissues
    Michelle L Oyen
    Department of Biophysical Sciences and Medical Physics, University of Minnesota, Minneapolis, MN 55455, USA
    J Biomech 39:2699-702. 2006
    ....
  97. ncbi Optical tweezers for measuring red blood cell elasticity: application to the study of drug response in sickle cell disease
    M M Brandão
    Department of Internal Medicine and Haemocentre, State University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Eur J Haematol 70:207-11. 2003
    ..RBC) with optical tweezers and dragging them through a viscous fluid we were able to measure their overall elasticity. We measured, and compared, the RBC deformability of 15 homozygous patients (HbSS) including five patients ..
  98. ncbi The effect of anterior cruciate ligament injury on knee joint function under a simulated muscle load: a three-dimensional computational simulation
    Guoan Li
    Orthopaedic Biomechanics Laboratory, Harvard Medical School, Massachusetts General Hospital Beth Israel Deaconess Medical Center, Boston 02215, USA
    Ann Biomed Eng 30:713-20. 2002
    ....
  99. ncbi The role of computational models in the search for the mechanical behavior and damage mechanisms of articular cartilage
    W Wilson
    Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, Eindhoven 5600 MB, The Netherlands
    Med Eng Phys 27:810-26. 2005
    ..Articular cartilage composition and structure are discussed in relation with degenerative changes, and how these affect mechanical properties...
  100. ncbi Sensitivities of medial meniscal motion and deformation to material properties of articular cartilage, meniscus and meniscal attachments using design of experiments methods
    Jiang Yao
    Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA
    J Biomech Eng 128:399-408. 2006
    ....
  101. ncbi Validation of a one-dimensional model of the systemic arterial tree
    Philippe Reymond
    Laboratory of Hemodynamics and Cardiovascular Technology, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Am J Physiol Heart Circ Physiol 297:H208-22. 2009
    ..The study constitutes a first validation of the complete 1-D model using human pressure and flow data and supports the applicability of the 1-D model in the human circulation...

Research Grants78

  1. ECM compliance and cell cycle control
    RICHARD ASSOIAN; Fiscal Year: 2012
    ..Our combined use of bioengineered substrata, biophysical measurements of tissue elasticity, cell and molecular biology, and in vivo mouse modeling provides us with a powerful interdisciplinary approach ..
  2. Extracellular Scaffold Elasticity and Binding Sites in Acinar Differentiation
    Melinda Larsen; Fiscal Year: 2013
    ..Recent studies have identified the importance of elasticity of the microenvironment in determining the extent of differentiation of mesenchymal stem cells;however, the ..
  3. Measurement of Renal Viscoelastic Properties with Ultrasound
    MATTHEW WILLIAM URBAN; Fiscal Year: 2013
    ..b>Elasticity imaging methods are emerging as a way to discriminate healthy versus diseased tissue based on the elasticity or ..
  4. Role of the Giant Protein Titin in Skeletal Muscle Structure and Function
    Henk L Granzier; Fiscal Year: 2013
    ..The PEVK is an important source of elasticity of the titin spring)...
  5. Non-invasive Ultrasound Elasticity Imaging (UEI) in Crohn's Disease
    Jonathan M Rubin; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Non-invasive Ultrasound Elasticity Imaging (UEI) in Crohn's Disease While current imaging systems such as computed tomography (CT) scanning can identify inflammation in Crohn's disease, ..
  6. Comparative Effectiveness of Advanced Diagnostic Imaging for Hepatic Fibrosis
    Jayant A Talwalkar; Fiscal Year: 2010
    ..In the present application, we propose to examine the comparative effectiveness of novel quantitative elasticity imaging techniques and serum marker fibrosis panels for detecting clinically significant hepatic fibrosis ..
  7. Development Of An Eye Drop To Treat Presbyopia
    William H Garner; Fiscal Year: 2012
    ..oxidation (PSH to PSSR and PSSP) to form protein cross-links contributes to the age-dependent decrease in lens elasticity underlying the loss of accommodative amplitude...
  8. The Role of Age-Related Matrix Stiffening in Endothelial Cell Function
    Cynthia A Reinhart-King; Fiscal Year: 2012
    ..Moreover, it has been shown that arterial elasticity is an independent predictor of cardiovascular mortality in patients over 70 years of age, and those with ..
  9. Fibrotic effects and regulation of MMP proteins in thrombus resolution
    Rajabrata Sarkar; Fiscal Year: 2009
    ..the role of these enzymes in thrombus recanalization, vein wall fibrosis and loss of vein wall compliance and elasticity using novel assays of mouse vein biomechanics...
  10. Novel Formulation of Topical Losartan for Treatment of Wounds in Aging
    JEREMY DAVID WALSTON; Fiscal Year: 2013
    ..breakdown and poor healing in older adults is both extrinsic (incontinence, immobility) and intrinsic (decreased elasticity, perfusion, and oxygenation)...
  11. Transforming Growth Factor-Beta (TGF-b) Signaling in Aged Skin
    Taihao Quan; Fiscal Year: 2013
    ..of this decline in human skin include fragility, impaired wound healing, increased incidence of cancer, reduced elasticity and tone, uneven color, and increased roughness...
  12. Metabolome and proteome profiles of emphysema and airway disease
    RUSSELL PAUL BOWLER; Fiscal Year: 2012
    ..Emphysema is one "phenotype of COPD" and is caused by loss of elasticity (increased compliance) of the lung tissue, from destruction of structures supporting the alveoli, and ..
  13. Determinants of Nicotine Reinforcement Thresholds and Demand Elasticity in Rats
    Mark G LeSage; Fiscal Year: 2013
    ..The primary hypothesis to be tested is that the nicotine reinforcement threshold and elasticity of demand (an index of reinforcing efficacy) for maintenance of nicotine self-administration (NSA) in adult rats ..
  14. Role of the physical microenvironment in tumor cell migration and the cell cycle
    KIMBERLY MURLEY STROKA; Fiscal Year: 2013
    ..during migration and division when cells are subjected to varying degrees of physical confinement and/or matrix elasticity. We will use a combination of microfabricated devices, cell engineering techniques, and high-resolution phase ..
  15. Nrf2 as a critical determinant of smooth muscle function
    Steven S An; Fiscal Year: 2013
    ..to fabricate micro- and nano-topographically defined substrata that better recapitulate ECM structure and elasticity of the airway wall...
  16. Structural origin of fibrin clot mechanical properties
    John W Weisel; Fiscal Year: 2012
    ..The results of these studies have clinical significance since clots with low elasticity and high plasticity tend to be associated with bleeding, while very stiff clots have been associated with ..
  17. HCV Disease Management in HIV- HCV Coinfected IDUs
    MARK SEBASTIAN SULKOWSKI; Fiscal Year: 2012
    ..Transient elastography is a novel, non-invasive method based on the observation that liver elasticity decreases as liver fibrosis increases...
  18. Scalable Units for Building Vascularized Cardiac Graft
    Lisa E Freed; Fiscal Year: 2013
    ..tissue engineering has demonstrated the promise of mechanically robust microfabricated biomaterials that combine elasticity and strength, and cell-based strategies that enhance the survival and vascular integration of transplanted heart ..
  19. FORCE SPECTROSCOPY AND STRUCTURAL BIOLOGY OF HAIR-CELL TIP LINKS
    Marcos Sotomayor; Fiscal Year: 2012
    ..The research work I did during my postdoctoral training answered some key questions about the elasticity of tip-link fragments, and how the tips of cadherin-23 and protocadheirn-15 interact with each other...
  20. Viscoelastic Properties of Human Facial Skin
    MARK WILLIAM BEATTY; Fiscal Year: 2012
    ..Therefore, the objective of this pilot project is to provide this baseline information by measuring facial skin elasticity in a human population...
  21. MSX2-Wnt Signaling in Cardiovascular Calcification
    Dwight A Towler; Fiscal Year: 2013
    ..is the chronic disease state characterized by thickening and hardening of arterial walls with loss of elasticity. Atherosclerosis, Monckeberg's medial calcific sclerosis, and arteriolosclerosis are the three ..
  22. Physical Regulation of Muscle Stem Cells in Bioengineered 3D Models
    PENNEY MARIE GILBERT; Fiscal Year: 2011
    ..In recent studies we demonstrated that substrate elasticity, a physical property of the MuSC niche, is a potent regulator of MuSC viability and self-renewal12,13...
  23. LIPID AND PROTEIN EFFECTS ON MONOLAYER STABILITY
    JOSEPH ANTHONY ZASADZINSKI; Fiscal Year: 2013
    ..This hypothesize that this interphase "lubricates" flow, causing the reductions in monolayer viscosity and elasticity, thereby enhancing the surfactant's ability to flow and cover the interface...
  24. Vitamin D Intervention and Atherosclerosis Progression in African American Women
    Howard N Hodis; Fiscal Year: 2013
    ..change of common carotid artery (CCA) intima-media thickness (IMT) and change of CCA stiffness (distensibility, elasticity and compliance) in computer image processed B-mode ultrasonograms will be determined...
  25. Fabrication of Denture Frameworks Using Titanium Alloys
    Marie Koike; Fiscal Year: 2010
    ..These alloys have a higher yield strength and a lower modulus of elasticity than conventional Co-Cr dental casting alloys, suggesting better performance when used to fabricate removable ..
  26. Post-Stroke Contributors to Increased Energetic Cost and Decreased Gait Stability
    JESSE CRAIG DEAN; Fiscal Year: 2012
    ..Similarly, the energetic demand of bouncing can be substantially reduced by taking advantage of tendon elasticity, while the simplicity of the task in comparison to walking eases quantification of system mechanics...
  27. Engineering vascular replacements for strength and elasticity
    Thomas N Wight; Fiscal Year: 2013
    ..We believe that this work will make significant progress toward the goal of an engineered vascular replacement that functions like a native blood vessel. ..
  28. Biomechanical Factors in Congenital Vascular Disease
    JESSICA WAGENSEIL; Fiscal Year: 2013
    ..In both COA and SVAS, elastic fiber fragmentation suggests that elasticity and mechanical properties of the wall may be important for disease pathology...
  29. 2011 Elastin and Elastic Fibers GRS GRC
    Richard A Pierce; Fiscal Year: 2011
    ..and pulmonary hypertension, aneurysms, and acquired skin disorders including UV damage-induced loss of dermal elasticity and dermal calcification...
  30. FORCE SPECTROSCOPY AND STRUCTURAL BIOLOGY OF HAIR-CELL TIP LINKS
    Marcos Sotomayor; Fiscal Year: 2013
    ..The research work I did during my postdoctoral training answered some key questions about the elasticity of tip-link fragments, and how the tips of cadherin-23 and protocadheirn-15 interact with each other...
  31. NMR studies of the effects of mode of birth on vaginal elastin
    Gregory Boutis; Fiscal Year: 2013
    ..component of the elastic fiber, imparts vertebrate tissues such as the heart, lungs and skin with remarkable elasticity. The loss of elastin architecture and function is a pathological characteristic of a number of human ..
  32. Stability of Pullmonary Airways
    JAMES BERNARD GROTBERG; Fiscal Year: 2010
    ..New to this revision is the inclusion of non-linear airway elasticity, airway smooth muscle dynamics, and effects of a surrounding parenchymal tethering...
  33. Single Molecule Studies of Titin Elasticity
    Julio M Fernandez; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The giant protein titin is responsible for the elasticity of heart muscle, playing a key role in the circulation of blood in humans...
  34. Innate Immune Mechanisms in Emphysema
    Patty J Lee; Fiscal Year: 2012
    ..Emphysema is characterized by gradual loss of lung elasticity and irreversible airspace enlargement, occurring to a certain extent in the normal aging process but ..
  35. Shear stress, SIRT1, and Arterial Stiffening
    JOHN Y_J SHYY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Arterial stiffening, manifested by thickening and reduced elasticity of conduit arteries, is an independent risk factor for stroke and heart disease...
  36. Petascale Molecular Dynamics Data Processing System
    Klaus Schulten; Fiscal Year: 2010
    ..involving DNA helicases, lipoprotein assembly, protein synthesis in the ribosome, muscle force generation and elasticity, voltage-gated ion channels, membrane trans- port, and bioenergetics, as well as DNA single base pair detection ..
  37. A Nanofibrous Bioactive Hemodialysis Access Graft
    SAIF G PATHAN; Fiscal Year: 2010
    ..Our hypothesis is that the strength and elasticity of the polymers combined with the synergisticbiological effects of the selected drugs should lead to a synthetic ..
  38. Behavioral Economic Analysis of Medical Marijuana Use in HIV+ Patients
    Mark K Greenwald; Fiscal Year: 2013
    ..sensitivity to experimental manipulation of unit price and income;and (B) determine whether marijuana price elasticity, cross-price elasticity with other drugs/therapies, and income elasticity differ across marijuana user groups...
  39. Molecular Mechanisms of L. monocytogenes Adhesion Through Surface Biopolymers
    NEHAL IBRAHIM ABU LAIL; Fiscal Year: 2010
    ..monocytogenes charge, hydrophobicity, and elasticity and thus their attachment to surfaces. I further hypothesize that epidemic strains of L...
  40. The Nano-mechanics of Polycystin-1
    ANDRES FERNANDO OBERHAUSER; Fiscal Year: 2010
    ..This technique offers the most direct way of studying the stability and elasticity of proteins that are exposed to mechanical forces and hence more closely approximate the conditions found in ..
  41. Nanomechanics of the extracellular matrix
    Julio M Fernandez; Fiscal Year: 2013
    ..These experiments will examine the mechanical unfolding transition states of crucial proteins involved in the elasticity and signaling of the extracellular matrix: fibronectin, and talin and model proteins such as ubiquitin and the ..
  42. Origins of Elasticity and Viscoelasticity in Ligaments
    Jeffrey A Weiss; Fiscal Year: 2013
    ....
  43. Mechanically Stable Blood Substitutes
    Andre Francis Palmer; Fiscal Year: 2010
    ..of individual actin-hemoglobin containing liposomes, and relate this to the rheology and average bending elasticity of actin-hemoglobin containing liposome dispersions...
  44. Novel Device for Sensitive, Small Sample Volume Assessment of Clot Elasticity
    Amy L Oldenburg; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): We propose to develop a novel device for the measurement of blood clot elasticity with improved accuracy and speed, and requiring smaller sample volumes...
  45. The Cellular and Molecular Basis of FOP Lesions
    Eileen M Shore; Fiscal Year: 2013
    ..However, cells exist in vivo in a mechanical environment, experiencing local microenvironments of varying elasticity/stiffness and dynamic mechanical signals (such as tensile deformation) through physiologic activities...
  46. ASSESSING LONG TERM OUTCOMES OF LIVING DONATION
    Bertram L Kasiske; Fiscal Year: 2013
    ..velocity, which has been shown to correlate with CVD in patients with CKD, as well as small and large artery elasticity using applanation tonometry at the 6-year visit in both donors and controls...
  47. Regulation of myelination by myosin II-mediated mechanotransduction
    Carmen V Melendez-Vasquez; Fiscal Year: 2013
    ..the lineage commitment of undifferentiated cells can be regulated by changes in the extracellular matrix (ECM) elasticity in a NMII-dependant manner...
  48. SENSIMMER? Virtual Phaco Trainer for Cataract Surgery
    P Banerjee; Fiscal Year: 2009
    ..Different degrees of simulated elasticity will be developed to simulate the variations in the elasticity of the human lens capsule...
  49. Vaginal Tactile Imager for Pelvic Floor Biomechanical Assessment
    Vladimir Egorov; Fiscal Year: 2013
    ..Changes in the elasticity of the vaginal walls, connective support tissues and muscles are thought to be significant factors in the ..
  50. Using micropost arrays to measure traction forces during dendritic cell motility
    Daniel A Hammer; Fiscal Year: 2013
    ..Furthermore, by varying the length of posts, we will determine the relationship between substrate elasticity and directional motion...
  51. Early Detection of Keratoconus
    Ronald H Silverman; Fiscal Year: 2013
    ..Our aim is to combine measurements of corneal elasticity, topography and epithelial thickness to develop means for early detection of KC.
  52. Protein carbohydrate interactions in the pathophysiology of asthma exacerbations
    John V Fahy; Fiscal Year: 2013
    ..In Aim 2 we will test if galactosyl sugars competing off lectin the binding to mucins to decrease mucu elasticity. We will screen a library of glycomimetic carbohydrates for their ability to prevent mucin lectin binding and to ..
  53. Arterial Elasticity, Subclinical, and Clinical CVD in MESA
    David R Jacobs; Fiscal Year: 2013
    ..wave reflections during the cardiac cycle, with particular patterns indicative of different levels of arterial elasticity (1/stiffness). The radial artery pulse contour can be registered noninvasively by radial artery tonometry...
  54. Dynamics of LCAT activation and lipoprotein remodeling
    Jere P Segrest; Fiscal Year: 2013
    ..1) A stochastic cloud of intrahelical and interhelical salt bridges, respectively, provide a spring-like elasticity (molecular "Slinky") and stickiness (molecular "Velcro") to apoA-I on HDL particles...
  55. Myocardial passive stiffness: effect of aging.
    WILLIAM CORSON HUNTER; Fiscal Year: 2010
    ..LV chamber diastolic reserve diminishes with age;while for normal end-diastolic pressures, chamber passive elasticity is preserved...
  56. "Smart" Materials to Engineer a More Complete Stem Cell Niche
    Adam Engler; Fiscal Year: 2009
    ..tissue cells when exposed to intrinsic properties of the extracellular matrix (ECM), such as matrix structure, elasticity, and composition...
  57. Mechanical Conditioning of Tissue Engineered Blood Vessels for Atherosclerosis
    Elaine Lee; Fiscal Year: 2012
    ..Mechanical testing using an Instron machine can measure for elasticity and tensile strength...
  58. Novel coatings on titanium implants for the delivery of stem cells
    MARTYN DARBY; Fiscal Year: 2012
    ..often relies on alloplastic materials such as titanium mesh, which can be easily shaped, has a modulus of elasticity similar to bone, and is biocompatible...
  59. Exploring current smokers? interest in using smokeless tobacco products
    RICHARD J O'CONNOR; Fiscal Year: 2013
    ..Cross-price elasticity will also be assessed by jointly presenting both classes of products, with the substitute offered at a fixed ..
  60. Noninvasive 3D Microscopic Studies of Corneal Elasticity and Collagen Structure
    Tibor Juhasz; Fiscal Year: 2011
    ..that microscopically measure the corneal structure and local biomechanical properties, such as corneal elasticity within the 3D space...
  61. Quantitative Mechanical Imaging for Improving Breast Ultrasound Diagnosis
    Timothy J Hall; Fiscal Year: 2013
    ..The combined device will be used to measure the contact pressure during ultrasound elasticity imaging of the breast...
  62. Single Channel Studies of the Fusion Pore
    Meyer B Jackson; Fiscal Year: 2013
    ..New results on membrane elasticity and exocytosis have allowed us to expand the scope of this study and determine how proteins can induce curvature ..
  63. GLASS TRANSITION TEMPERATURE AND WEAR OF DENTAL RESINS
    JAN STANNARD; Fiscal Year: 1993
    ..The sophisticated viscoanalyzer is also capable of measuring modulus of elasticity on macro composite samples over a range of frequencies and temperatures...
  64. Integrated Multifunctional Imaging of Deep Vein Thrombosis
    Walter Scott; Fiscal Year: 2009
    ..In addition to elasticity contrast, optical absorption of DVT changes with blood clot maturation the acute clots are associated with high ..
  65. MEMBRANE DYNAMICS AND STEROL BIOSYNTHESIS IN YEAST
    Robin Wright; Fiscal Year: 1999
    ..These deposits block blood vessels and decrease their elasticity, increasing susceptibility to high blood pressure, stroke, and heart disease, thus contributing to the leading ..
  66. Matrix-induced Myogenesis & Pharmaco-Screens of MSCs
    Dennis Discher; Fiscal Year: 2009
    ..cell culture models of normal and diseased myogenesis, focused on the influence of normal and abnormal matrix elasticity, in order to assess known drugs (eg...
  67. Scalable Purification of Silk-Like Proteins from Transgenic Tobacco
    WILLIAM MARCOTTE; Fiscal Year: 2007
    ..Spider silks are protein fibers that exhibit a remarkable combination of tensile strength, resilience, and elasticity. This makes them desirable for biomedical applications such as artificial tendons and ligaments, cell scaffolds ..
  68. Designing Spider Silk Proteins as Novel Biomaterials
    Randolph Lewis; Fiscal Year: 2009
    ..Spider silk, which has been evolving for over 450 million years, has a tensile strength greater than steel and elasticity greater than nylon...
  69. Elastic biodegradable ureteral stent
    Haesun Park; Fiscal Year: 2009
    ..The two main properties to be optimized in this study are elasticity and degradation...
  70. BIOLOGICAL ROLE OF LYSYL OXIDASE-2 IN MATRIX DEVELOPMENT
    Ian Hornstra; Fiscal Year: 1999
    ..Elastin and collagen are the major components of the extracellular matrix that impart elasticity and high tensile strength, respectively, to mammalian connective tissues...
  71. Human Laboratory Model of Cocaine Treatment: Behavioral Economic Analysis
    Mark K Greenwald; Fiscal Year: 2010
    ..lower-magnitude continuous positive reinforcement increases cocaine elasticity;(b) intermittent positive reinforcement conditions (which will be equated in magnitude with continuous ..
  72. CIGARETTE TAXES AND PRENATAL SMOKING
    Theodore Joyce; Fiscal Year: 2002
    ..an increase in cigarette excise taxes was associated with a 5 percent decline in smoking by pregnant women, an elasticity of-0.5. In 1999, California increased the excise tax on cigarettes by $0...
  73. STRETCH CHANGES IN THE RABBIT CERVIX BY PROSTAGLANDIN
    John Conrad; Fiscal Year: 1980
    ..Either way cervical elasticity is an important quantity to be measured and controlled in any attempt to manipulate labor...
  74. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard B Weinberg; Fiscal Year: 2010
    ..Using novel surface chemistry techniques, we have found that apo A-IV displays unique elasticity at expanding interfaces, and that C-terminal mutations in apo A-IV alter its interfacial activity, elasticity, ..
  75. STABILIZATION OF THE CUMULUS ECM AND OVULATION
    Larry Sherman; Fiscal Year: 2002
    ..This apparent transesterification reaction results in an increase in COC viscosity and elasticity and thus, the "superstabilization" of the cECM...
  76. Genetics of Sagg: A Heritable Mouse Model for Cutis Laxa
    Paul Christner; Fiscal Year: 2004
    ..tissue disease of the skin of unknown cause, characterized by sagging skin, premature wrinkling and reduced skin elasticity. It occurs in heritable and acquired forms...
  77. DIRECT OBSERVATION OF INTERFACIAL PROCESS
    Vladimir Hlady; Fiscal Year: 2003
    ..to relate it to the two-dimensional variation of biomaterial's surface properties, such as surface energy and elasticity. We propose to perform this analysis on a size scale that is on the order of protein size (i.e...
  78. DIRECT OBSERVATION OF INTERFACIAL PROCESS
    Vladimir Hlady; Fiscal Year: 2001
    ..to relate it to the two-dimensional variation of biomaterial's surface properties, such as surface energy and elasticity. We propose to perform this analysis on a size scale that is on the order of protein size (i.e...