Summary: The branch of physics which deals with the motions of material bodies, including kinematics, dynamics, and statics. When the laws of mechanics are applied to living structures, as to the locomotor system, it is referred to as BIOMECHANICS. (From Dorland, 28th ed)

Top Publications

  1. pmc Thermodynamics and mechanics of membrane curvature generation and sensing by proteins and lipids
    Tobias Baumgart
    Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Phys Chem 62:483-506. 2011
  2. pmc A discrete model to study reaction-diffusion-mechanics systems
    Louis D Weise
    Department of Theoretical Biology, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 6:e21934. 2011
  3. ncbi Equilibrium regained: from nonequilibrium chaos to statistical mechanics
    D A Egolf
    Center for Nonlinear Studies MS B258, Theoretical Division and Condensed Matter and Thermal Physics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Science 287:101-4. 2000
  4. pmc A multiscale red blood cell model with accurate mechanics, rheology, and dynamics
    Dmitry A Fedosov
    Division of Applied Mathematics, Brown University, Providence, Rhode Island, USA
    Biophys J 98:2215-25. 2010
  5. ncbi Are scaling laws on strength of solids related to mechanics or to geometry?
    Alberto Carpinteri
    Politecnico di Torino, Department of Structural Engineering and Geotechnics, Corso Duca degli Abruzzi 24, 10129 Torino, Italy
    Nat Mater 4:421-3. 2005
  6. ncbi Theoretical mechanics: crowd synchrony on the Millennium Bridge
    Steven H Strogatz
    Department of Theoretical and Applied Mechanics, Cornell University, Ithaca, New York 14853 1503, USA
    Nature 438:43-4. 2005
  7. ncbi The role of skirt geometry of dental crowns on the mechanics of failure: experimental and numerical study
    Anne Whitton
    School of Mechanical Engineering, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Med Eng Phys 30:661-8. 2008
  8. ncbi Neocortical dynamics at multiple scales: EEG standing waves, statistical mechanics, and physical analogs
    Lester Ingber
    Lester Ingber Research, Ashland, OR 97520, USA
    Math Biosci 229:160-73. 2011
  9. pmc Design of biomimetic fibrillar interfaces: 2. Mechanics of enhanced adhesion
    C Y Hui
    Department of Theoretical and Applied Mechanics, Cornell University, 212 Kimball Hall, Ithaca, NY 14853, USA
    J R Soc Interface 1:35-48. 2004
  10. ncbi Effects of salicylate on plasma membrane mechanics
    Sergey A Ermilov
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, Texas 77251 1892, USA
    J Neurophysiol 94:2105-10. 2005

Detail Information

Publications244 found, 100 shown here

  1. pmc Thermodynamics and mechanics of membrane curvature generation and sensing by proteins and lipids
    Tobias Baumgart
    Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Phys Chem 62:483-506. 2011
    ..Finally, we discuss relatively simple thermodynamic/mechanical models that allow quantitative interpretation of experimental observations...
  2. pmc A discrete model to study reaction-diffusion-mechanics systems
    Louis D Weise
    Department of Theoretical Biology, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 6:e21934. 2011
    This article introduces a discrete reaction-diffusion-mechanics (dRDM) model to study the effects of deformation on reaction-diffusion (RD) processes...
  3. ncbi Equilibrium regained: from nonequilibrium chaos to statistical mechanics
    D A Egolf
    Center for Nonlinear Studies MS B258, Theoretical Division and Condensed Matter and Thermal Physics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Science 287:101-4. 2000
    ..such as Gibbs distributions and detailed balance are recovered at these scales, which suggests that the macroscopic behavior of some far-from-equilibrium systems might be understood in terms of equilibrium statistical mechanics.
  4. pmc A multiscale red blood cell model with accurate mechanics, rheology, and dynamics
    Dmitry A Fedosov
    Division of Applied Mathematics, Brown University, Providence, Rhode Island, USA
    Biophys J 98:2215-25. 2010
    ..We present a multiscale RBC model that is able to predict RBC mechanics, rheology, and dynamics in agreement with experiments...
  5. ncbi Are scaling laws on strength of solids related to mechanics or to geometry?
    Alberto Carpinteri
    Politecnico di Torino, Department of Structural Engineering and Geotechnics, Corso Duca degli Abruzzi 24, 10129 Torino, Italy
    Nat Mater 4:421-3. 2005
    ..In spite of the prevailing view, which considers mechanics as the real cause of such effects, here, we propose a different argument, purely based on geometry...
  6. ncbi Theoretical mechanics: crowd synchrony on the Millennium Bridge
    Steven H Strogatz
    Department of Theoretical and Applied Mechanics, Cornell University, Ithaca, New York 14853 1503, USA
    Nature 438:43-4. 2005
    ..Our approach should help engineers to estimate the damping needed to stabilize other exceptionally crowded footbridges against synchronous lateral excitation by pedestrians...
  7. ncbi The role of skirt geometry of dental crowns on the mechanics of failure: experimental and numerical study
    Anne Whitton
    School of Mechanical Engineering, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Med Eng Phys 30:661-8. 2008
    ..of a brittle glass coating on a compliant polymeric substrate, to illustrate the role of skirt geometry on the mechanics of failure evolution...
  8. ncbi Neocortical dynamics at multiple scales: EEG standing waves, statistical mechanics, and physical analogs
    Lester Ingber
    Lester Ingber Research, Ashland, OR 97520, USA
    Math Biosci 229:160-73. 2011
    ..A statistical mechanics of neocortical interactions (SMNI) calculates oscillatory behavior consistent with typical EEG, within columns, ..
  9. pmc Design of biomimetic fibrillar interfaces: 2. Mechanics of enhanced adhesion
    C Y Hui
    Department of Theoretical and Applied Mechanics, Cornell University, 212 Kimball Hall, Ithaca, NY 14853, USA
    J R Soc Interface 1:35-48. 2004
    ..We obtain the practical work of adhesion for an idealized fibrillated interface under equal load sharing. We then analyse the peeling of a fibrillar surface from a rigid substrate and establish a criterion for ELS...
  10. ncbi Effects of salicylate on plasma membrane mechanics
    Sergey A Ermilov
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, Texas 77251 1892, USA
    J Neurophysiol 94:2105-10. 2005
    ..We used optical tweezers to study the effects of Sal on the mechanics of the cell plasma membrane...
  11. ncbi Mechanics of airflow in the human nasal airways
    D J Doorly
    Department of Aeronautics, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Respir Physiol Neurobiol 163:100-10. 2008
    The mechanics of airflow in the human nasal airways is reviewed, drawing on the findings of experimental and computational model studies...
  12. pmc Molecular mechanics of filamin's rod domain
    Kevin S Kolahi
    Molecular Cell Biomechanics Laboratory, Department of Bioengineering and Biophysics Graduate Group, University of California, Berkeley, California 94720, USA
    Biophys J 94:1075-83. 2008
    ..Actin-binding proteins, e.g., filamin, can naturally contribute to the mechanics and function of the actin cytoskeleton...
  13. ncbi Molecular mechanics methods for predicting protein-ligand binding
    Niu Huang
    Department of Pharmaceutical Chemistry, University of California San Francisco, UCSF MC 2240, Genentech Hall, Room N472C, 600 16th St, San Francisco, CA 94158 2517, USA
    Phys Chem Chem Phys 8:5166-77. 2006
    ..We provide an overview of recent work using molecular mechanics energy functions to address this challenge...
  14. ncbi Intelligence by mechanics
    Reinhard Blickhan
    Motion Science, Seidelstrasse 20, Institute of Sport Science, Friedrich Schiller University Jena, 07749 Jena, Germany
    Philos Trans A Math Phys Eng Sci 365:199-220. 2007
    ..To ensure secure foothold visco-elastic suspended muscles serve as shock absorbers. Experiments with technically implemented leg models, which explore some of these principles, are promising...
  15. pmc The differential role of motor cortex in stretch reflex modulation induced by changes in environmental mechanics and verbal instruction
    Jonathan Shemmell
    Sensory Motor Performance Program, The Rehabilitation Institute of Chicago, Chicago, Illinois 60611, USA
    J Neurosci 29:13255-63. 2009
    ..These results demonstrate that task-dependent changes in reflex function can be mediated through multiple neural pathways and that these pathways have task-specific roles...
  16. pmc DNA mechanics as a tool to probe helicase and translocase activity
    Timothee Lionnet
    Laboratoire de Physique Statistique de l Ecole Normale Superieure, UMR 8550 CNRS, 24 rue Lhomond, 75231 Paris Cedex 05, France
    Nucleic Acids Res 34:4232-44. 2006
    ..We then discuss experiments on two dsDNA translocases: the RuvAB motor studied on its natural substrate, the Holliday junction, and the chromosome-segregation motor FtsK, showing its unusual coupling to DNA supercoiling...
  17. pmc Cadherin mechanics and complexation: the importance of calcium binding
    Fabien Cailliez
    Laboratoire de Biochimie Theorique, CNRS, UPR 9080, Institut de Biologie Physico Chimique, Paris 75005, France
    Biophys J 89:3895-903. 2005
    ..Here again, it is shown that the presence of calcium is an important factor in both rigidifying and stabilizing the complex...
  18. ncbi A novel quantitative approach for evaluating contact mechanics of meniscal replacements
    E Linder-Ganz
    Research and Development Center, Active Implants Corporation, Netanya, 42505 Israel
    J Biomech Eng 132:024501. 2010
  19. ncbi In-vivo implant mechanics of flexible, silicon-based ACREO microelectrode arrays in rat cerebral cortex
    Winnie Jensen
    Center for Sensory Motor Interaction, Department of Health Science, Aalborg University, 9220 Aalborg, Denmark
    IEEE Trans Biomed Eng 53:934-40. 2006
    ..The objective of the present work was to investigate the in vivo implant mechanics of flexible, silicon-based ACREO microelectrode arrays recently developed by the VSAMUEL consortium (European ..
  20. ncbi A micro-mechanics model of dentin mechanical properties
    Qing Hua Qin
    Department of Mechanics, Tianjin University, Tianjin 300072, China
    Biomaterials 25:5081-90. 2004
    Application of a micro-mechanics cell model to dentin composites for determination of their effective mechanical properties is discussed in this paper...
  21. ncbi Wind-induced dust generation and transport mechanics on a bare agricultural field
    Ted M Zobeck
    Wind Erosion and Water Conservation Research Unit, USDA, Agricultural Research Service, 3810 4th Street Lubbock, TX 79415, USA
    J Hazard Mater 132:26-38. 2006
    ..established by the United States Environmental Protection Agency, information on dust generation and transport mechanics is needed to determine the particulate hazard of dust sources...
  22. pmc Single-molecule force spectroscopy reveals a mechanically stable protein fold and the rational tuning of its mechanical stability
    Deepak Sharma
    Department of Chemistry, University of British Columbia, Vancouver, BC, Canada
    Proc Natl Acad Sci U S A 104:9278-83. 2007
  23. pmc Nonlinear mechanics of soft fibrous networks
    A Kabla
    Division of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
    J R Soc Interface 4:99-106. 2007
    ..A simple microscopic model allows us to explain these features of our observations, and provides us with a baseline framework to understand active biomechanical networks...
  24. pmc Neutrophil-bead collision assay: pharmacologically induced changes in membrane mechanics regulate the PSGL-1/P-selectin adhesion lifetime
    K E Edmondson
    Institute for Medicine and Engineering, Department of Bioengineering, University of Pennsylvania, 3320 Smith Walk, Philadelphia, PA 19104, USA
    Biophys J 89:3603-14. 2005
    ..Membrane tether growth can be enhanced or reduced pharmacologically with consequent effects on PSGL-1/P-selectin lifetimes...
  25. ncbi Tibiofemoral contact mechanics after serial medial meniscectomies in the human cadaveric knee
    Stephen J Lee
    The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Am J Sports Med 34:1334-44. 2006
    There is no consensus regarding the extent of meniscectomy leading to deleterious effects on tibiofemoral contact mechanics.
  26. ncbi Scale relativity theory and integrative systems biology: 2. Macroscopic quantum-type mechanics
    Laurent Nottale
    LUTH, CNRS, Observatoire de Paris and Paris Diderot University Paris VII, 5 place Jules Janssen, 92190 Meudon, France
    Prog Biophys Mol Biol 97:115-57. 2008
  27. ncbi Mechanical unfolding of proteins: insights into biology, structure and folding
    Julia R Forman
    Cambridge University Department of Chemistry, MRC Centre for Protein Engineering, Lensfield Road, Cambridge CB2 1EW, UK
    Curr Opin Struct Biol 17:58-66. 2007
    ..Finally, recent technological developments offer exciting new avenues for experimental studies...
  28. pmc Prediction of the translocation kinetics of a protein from its mechanical properties
    Daniel K West
    School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom
    Biophys J 91:L51-3. 2006
  29. ncbi Mechanics of the taper integrated screwed-in (TIS) abutments used in dental implants
    Dincer Bozkaya
    Department of Mechanical Engineering, Northeastern University, 334 Snell engineering, Boston, MA 02115, USA
    J Biomech 38:87-97. 2005
    ..tightening and loosening torque values by combining the equations related to the tapered interface with screw mechanics equations...
  30. pmc More than a monolayer: relating lung surfactant structure and mechanics to composition
    Coralie Alonso
    Department of Chemical Engineering and Materials, University of California, Santa Barbara, California 93106 5080, USA
    Biophys J 87:4188-202. 2004
    ..The high viscosity may lead to high monolayer collapse pressures, help prevent atelectasis, and minimize the flow of lung surfactant out of the alveoli due to surface tension gradients...
  31. ncbi Mechanics of coracoacromial ligament transfer augmentation for acromioclavicular joint injuries
    David R Wilson
    Orthopaedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
    J Biomech 38:615-9. 2005
    ..107). We anticipate that, when surgery is indicated for treating acromioclavicular joint injury, an augmented Weaver-Dunn reconstruction will yield a joint that is less painful, more functional and less likely to require revision...
  32. ncbi Fluid mechanics of electroosmotic flow and its effect on band broadening in capillary electrophoresis
    Sandip Ghosal
    Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA
    Electrophoresis 25:214-28. 2004
    ..In this paper, the basic facts about EOF are reviewed from the perspective of fluid mechanics and its effect on separations in free solution capillary zone electrophoresis is discussed in the light of ..
  33. ncbi Understanding molecular structure from molecular mechanics
    Norman L Allinger
    Department of Chemistry, Chemistry Annex, University of Georgia, Athens, GA 30602
    J Comput Aided Mol Des 25:295-316. 2011
    Molecular mechanics gives us a well known model of molecular structure. It is less widely recognized that valence bond theory gives us structures which offer a direct interpretation of molecular mechanics formulations and parameters...
  34. pmc Molecular mechanics calculations on Rous sarcoma virus protease with peptide substrates
    I T Weber
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Protein Sci 6:2365-74. 1997
    ..56 for all substrates. These results are compared to those from similar calculations on HIV-1 protease and discussed in relation to the rate-limiting steps in the catalytic mechanism and the entropic contributions...
  35. pmc Structural hierarchy governs fibrin gel mechanics
    Izabela K Piechocka
    Biological Soft Matter Group, Foundation for Fundamental Research on Matter, Institute for Atomic and Molecular Physics, Amsterdam, The Netherlands
    Biophys J 98:2281-9. 2010
    ..Moreover, in contrast with other biopolymers, fibrin fibers intrinsically stiffen when stretched. The resulting hierarchy of elastic regimes explains the incredible resilience of fibrin clots against large deformations...
  36. ncbi Statistical mechanics of base stacking and pairing in DNA melting
    Vassili Ivanov
    Department of Physics and Astronomy, University of California Los Angeles, Los Angeles, CA 90095 1547, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 70:051907. 2004
    We propose a statistical mechanics model for DNA melting in which base stacking and pairing are explicitly introduced as distinct degrees of freedom...
  37. ncbi [In vitro elution and mechanical properties of antibiotic-loaded SmartSet HV and Palacos R acrylic bone cements]
    P M S Simpson
    Department of Orthopaedics, University of Edinburgh, New Royal Infirmary, Edinburgh, UK
    Orthopade 34:1255-62. 2005
    ..An in vitro antibiotic elution and mechanical study was therefore carried out to compare a newer bone cement, SmartSet, with the established Palacos R cement...
  38. ncbi Peeling force spectroscopy: exposing the adhesive nanomechanics of one-dimensional nanostructures
    M C Strus
    School of Mechanical Engineering and Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana, USA
    Nano Lett 8:544-50. 2008
    ..This opens up the possibility of quantitative comparison and control of adhesion between nanotubes or nanowires on different substrates...
  39. ncbi Suspended mechanical structures based on elastic silicon nanowire arrays
    Alvaro San Paulo
    Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, California 94720, USA
    Nano Lett 7:1100-4. 2007
    ..Our results point out important differences in the morphology and mechanical behavior of the fabricated nanowire-based structures with respect to equivalent bulk material structures...
  40. ncbi Nanomechanical characterization of one-step combustion-synthesized Al(4)B(2)O(9) and Al(18)B(4)O(33) nanowires
    Xinyong Tao
    Department of Mechanical Engineering, University of South Carolina, 300 Main Street, Columbia, South Carolina 29208, USA
    Nano Lett 7:3172-6. 2007
    ..A 70% reduction in elastic modulus was found in Al(18)B(4)O(33) nanowires compared with their bulk counterpart. Al(18)B(4)O(33) nanowires exhibited higher hardness and elastic modulus than Al(4)B(2)O(9) nanowires...
  41. ncbi Effects of fibronectin and laminin on structural, mechanical and transport properties of 3D collageneous network
    D Guarnieri
    Interdisciplinary Centre of Biomedical Materials CRIB, University of Naples Federico II, P le Tecchio 80, Naples, Italy
    J Mater Sci Mater Med 18:245-53. 2007
    ..In addition, high FN and LM concentrations affected collagen fibre assembly and structure and induced drastic effects on rheological and transport properties...
  42. ncbi Nanomechanics of silicon surfaces with atomic force microscopy: an insight to the first stages of plastic deformation
    Sergi Garcia-Manyes
    Center for Bioengineering of Catalonia CREBEC and Department of Physical Chemistry, University of Barcelona, Spain
    J Chem Phys 123:114711. 2005
    ..Hardness measurements with penetration depths as small as 1 nm yield H= approximately 25 GPa, thus showing a drastic increase with penetration depths below 5 nm...
  43. ncbi The mechanical integrity of in vivo engineered heterotopic bone
    Patrick H Warnke
    Department of Oral and Maxillofacial Surgery, University of Kiel, Arnold Heller Str 16, 24 105 Kiel, Germany
    Biomaterials 27:1081-7. 2006
    ..This differed significantly from the much lower compression resistance seen in the unadulterated BioOss [0.92 MPa (SD+/-0.04)]. Following this, the in vivo engineered bone has a similar mechanical compression stability as natural bone...
  44. ncbi Photomechanical actuation in polymer-nanotube composites
    Samit V Ahir
    Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, UK
    Nat Mater 4:491-5. 2005
    ..It is thought that no other materials can display this continuously reversible response of so large a magnitude, making rubber nanocomposites important for actuator applications...
  45. ncbi Nanomechanical investigation of Mo6S9-x Ix nanowire bundles
    Andras Kis
    Institut de la Physique de la Matière Complexe, EPFL, Lausanne, Switzerland
    Small 3:1544-8. 2007
  46. ncbi In vivo biocompatibility and mechanical properties of porous zein scaffolds
    Hua Jie Wang
    College of Life Science and Biotechnology, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China
    Biomaterials 28:3952-64. 2007
  47. ncbi Mechanics of curved plasma membrane vesicles: resting shapes, membrane curvature, and in-plane shear elasticity
    Tadashi Kosawada
    Department of Mechanical Systems Engineering, Yamagata University, Jonan 4 3 16, Yonezawa 992 8510, Japan
    J Biomech Eng 127:229-36. 2005
    ..To enhance our understanding of plasmalemmal vesicles we need to improve the understanding of the mechanics in regions of high membrane curvatures...
  48. ncbi Mechanical properties of two orthodontic adhesive materials polymerized with halogen and plasma curing
    S Mifsud
    LEIBO, Faculté d Odontologie de Lyon, France
    Biomed Mater Eng 15:269-77. 2005
  49. ncbi Macroscopic tuning of nanomechanics: substrate bending for reversible control of frequency and quality factor of nanostring resonators
    Scott S Verbridge
    Department of Physics and the Cornell Center for Materials Research, Cornell University, Ithaca, New York 14853, USA
    Nano Lett 7:1728-35. 2007
  50. ncbi 3D fiber-deposited scaffolds for tissue engineering: influence of pores geometry and architecture on dynamic mechanical properties
    L Moroni
    Institute for Biomedical Technology, University of Twente, P O Box 217, 7500 AE Enschede, The Netherlands
    Biomaterials 27:974-85. 2006
    ..This investigation showed that viscoelastic properties of 3DF scaffolds could be modulated to accomplish mechanical requirements for tailored tissue engineered applications...
  51. ncbi Mechanical properties of continuously spun fibers of carbon nanotubes
    Marcelo Motta
    Department of Materials Science and Metallurgy, University of Cambridge, Pembroke Street, Cambridge CB2 3QZ, UK
    Nano Lett 5:1529-33. 2005
    ..46 GPa (equivalent to 0.70 N/tex assuming a density of 2.1 g/cm(3)). The experiments indicate that significant improvements in the mechanical properties can be accomplished by optimizing the process conditions...
  52. ncbi Thermomechanical investigation of the cortical bone analogue in third-generation Sawbones femurs
    C G R Bell
    School of Engineering Systems, Queensland University of Technology, GPO Box 2434, Brisbane, Queensland 4001, Australia
    Proc Inst Mech Eng H 221:213-7. 2007
    ..SGFR epoxy Sawbones do not accurately represent the material properties of bone at body temperature...
  53. ncbi Mechanical properties and crystallization behaviors of nanostructured-Zno/PET in-situ composites
    Jie Tao
    College of Material Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, PR China
    J Nanosci Nanotechnol 6:3939-42. 2006
    ..2 wt% ZnO/PET composite could be a promising upgrade of PET due to the considerable improvement in mechanical properties...
  54. ncbi Mechanical testing of isolated amorphous silicon slanted nanorods
    C Gaire
    Department of Physics, Applied Physics and Astronomy, Rensselaer Polytechnic Institute, Troy, New York 12180 3590, USA
    J Nanosci Nanotechnol 5:1893-7. 2005
    ..14 +/- 10.21) GPa. No size effect of this parameter was observed within the accuracy of the present measurement...
  55. ncbi Size effects on the mechanical behavior of nanoporous Au
    Juergen Biener
    Nanoscale Synthesis and Characterization Laboratory, Lawrence Livermore National Laboratory, P O Box 808, L 367, Livermore, California 94550, USA
    Nano Lett 6:2379-82. 2006
    ..We find that nanoporous gold can be as strong as bulk Au, despite being a highly porous material, and that the ligaments in nanoporous gold approach the theoretical yield strength of Au...
  56. ncbi The role of interfacial mechanics in the prediction of global mechanical behavior of a bioactive composite: an in vitro study
    Emily Ho
    Materials Science and Engineering Department at Drexel University, Philadelphia, PA, USA
    J Oral Implantol 32:63-71. 2006
    ..Thus, nano-indentation is a sensitive technique for examining interfacial mechanics and mechanical consequences of biologic reactivity of composite materials.
  57. ncbi Thermomechanical analysis of ultra-high molecular weight polyethylene-metal hip prostheses
    M Rocchi
    Laboratorio di Tecnologia Medica, Istituti Ortopedici Rizzoli, Bologna, Italy
    Proc Inst Mech Eng H 221:561-8. 2007
    ..The full coupling between the thermal and the mechanical conditions used in this study appears to be necessary if accurate predictions of the polyethylene deformation are required...
  58. ncbi Complex buckling instability patterns of nanomembranes with encapsulated gold nanoparticle arrays
    Chaoyang Jiang
    Department of Materials Science and Engineering, Iowa State University, Ames, Iowa 50011, USA
    Nano Lett 6:2254-9. 2006
    ..The binary buckling pattern observed here allowed the "one-shot" evaluation of the elastic moduli of two compositionally different regions (with and without gold nanoparticles)...
  59. ncbi Novel method for mechanical characterization of polymeric nanofibers
    Mohammad Naraghi
    Aerospace Engineering, University of Illinois at Urbana Champaign, 325 Talbot Lab, Urbana, IL 61801, USA
    Rev Sci Instrum 78:085108. 2007
    ..6+/-1.5 GPa and large irreversible strains that exceeded 220%. The large fiber stretch ratios were the result of a cascade of periodic necks that formed during cold drawing of the nanofibers...
  60. ncbi High maneuverability guidewire with functionally graded properties using new superelastic alloys
    Y Sutou
    Tohoku University Biomedical Engineering Research Organization, TUBERO Aobayama Material Science Branch, Sendai, Japan
    Minim Invasive Ther Allied Technol 15:204-8. 2006
    ..Moreover, a metallic catheter using a Ni-free Ti-based SMA with high biocompatibility is introduced...
  61. pmc Nano measurements with micro-devices: mechanical properties of hydrated collagen fibrils
    S J Eppell
    Case Western Reserve University, Department of Biomedical Engineering, Cleveland, OH 44106, USA
    J R Soc Interface 3:117-21. 2006
    ..We used the device to obtain the first stress-strain curve of an isolated collagen fibril producing the modulus and some fatigue properties of this soft nanofibril...
  62. ncbi Mechanically mediated electron transfer in model metallo-enzyme interfaces
    L Yu Gorelik
    Department of Applied Physics, Chalmers University of Technology, 412 96 Goteborg, Sweden
    Biosens Bioelectron 22:405-8. 2006
    ..In this paper we will focus on a special type of nanoelectro-mechanical processes in this system and investigate single electronic effects in there...
  63. ncbi Dramatic effect of dispersed carbon nanotubes on the mechanical and electroconductive properties of polymers derived from ionic liquids
    Takanori Fukushima
    Aida Nanospace Project, ERATO SORST Japan Science and Technology Agency, National Museum of Emerging Science and Innovation, 2 41 Aomi, Koto ku, Tokyo 135 0064, Japan
    Small 2:554-60. 2006
    ..Although a bucky plastic derived from a vinylimidazolium ion-based ionic liquid monomer shows a comparable conductivity to that of the methacrylate version, the film is brittle irrespective of the presence or absence of SWNTs...
  64. ncbi Mechanically tunable three-dimensional elastomeric network/air structures via interference lithography
    Ji Hyun Jang
    Institute for Soldier Nanotechnologies, Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nano Lett 6:740-3. 2006
    ..Brillouin light scattering (BLS) was employed to measure phononic modes of the structure as a function of mechanical strain. The results demonstrate that the phononic band diagram of such structures can be tuned mechanically...
  65. ncbi Measurement of the bending strength of vapor-liquid-solid grown silicon nanowires
    Samuel Hoffmann
    EMPA Materials Science and Technology, Feuerwerkerstrasse 39, 3602 Thun, Switzerland
    Nano Lett 6:622-5. 2006
    ..This value is close to the theoretical fracture strength, which indicates that surface or volume defects, if present, play only a minor role in fracture initiation...
  66. ncbi Piezoelectric thin films: evaluation of electrical and electromechanical characteristics for MEMS devices
    Klaus Prume
    aixACCT Systems GmbH, Aachen, Germany
    IEEE Trans Ultrason Ferroelectr Freq Control 54:8-14. 2007
    ..These data are essential for piezoelectric thin film process specification and the design and qualification of microelectromechanical systems devices...
  67. ncbi Morphology and mechanical stability of amyloid-like peptide fibrils
    Patrick Mesquida
    London Centre for Nanotechnology, Department of Medicine, University College London, 5 University Street, London, WC1E 6JJ, UK
    J Mater Sci Mater Med 18:1325-31. 2007
    ..Additional investigations by circular-dichroism spectroscopy showed that dispersed fibrils were structurally stable in aqueous solution between pH 3 and pH 8, and in sodium phosphate buffer of concentration between 50 mM and 1 M...
  68. ncbi Unique mechanical properties of nanostructured metals
    Nobuhiro Tsuji
    Department of Adaptive Machine Systems, Osaka University, Suita 565 0871, Japan
    J Nanosci Nanotechnol 7:3765-70. 2007
    ..The unique properties seem to be attributed to the characteristic structures of the nano-metals full of grain boundaries...
  69. ncbi Mechanical properties of organic nanofibers
    Jakob Kjelstrup-Hansen
    MIC Department of Micro and Nanotechnology, Technical University of Denmark, Building 345 east, 2800 Kgs Lyngby, Denmark
    Small 2:660-6. 2006
  70. ncbi Influence of a pre-blended antibiotic (gentamicin sulfate powder) on various mechanical, thermal, and physical properties of three acrylic bone cements
    Gladius Lewis
    Department of Mechanical Engineering, The University of Memphis, Memphis, Tennessee 38152, USA
    J Biomater Appl 20:377-408. 2006
  71. ncbi An instrument for environmental control of vapor pressure and temperature for tensile creep and other mechanical property measurements
    P W Majsztrik
    Chemistry Department, Princeton University, Princeton, New Jersey 08544, USA
    Rev Sci Instrum 78:103904. 2007
    ..The main features of the instrument are presented along with experimental methodology and analysis of results. The adaptation of the instrument to other mechanical tests is briefly described...
  72. ncbi In-vitro investigation on suitability of light-cured resins for interocclusal splints : part II: surface hardness
    Gholamreza Danesh
    Department of Orthodontics and Dentofacial Orthopedics, University of Munster, Munster, Germany
    J Orofac Orthop 67:138-47. 2006
    ..The aim of the present study was to determine the surface hardness of light- and auto-cured resins for the fabrication of occlusal splints employing Vickers hardness measurements...
  73. ncbi Structural and mechanical study of a self-assembling protein nanotube
    J F Graveland-Bikker
    NIZO Food Research, P O Box 20, 6710 BA Ede, The Netherlands
    Nano Lett 6:616-21. 2006
  74. ncbi Experimental and computational approach for evaluating the mechanical characteristics of dental composite resins with various filler sizes
    Yasuhiro Tanimoto
    Department of Dental Biomaterials, Nihon University School of Dentistry at Matsudo, 2 870 1 Sakaecho nishi, Matsudo, Chiba 271 8587, Japan
    Acta Biomater 2:633-9. 2006
    ..In addition, FE analysis was effective for evaluating stress distributions of dental composite resins with various filler sizes...
  75. ncbi Mechanical properties of carbon nanotubes and their polymer nanocomposites
    Hiroaki Miyagawa
    School of Packaging, Michigan State University, East Lansing, MI 48824 1223, USA
    J Nanosci Nanotechnol 5:1593-615. 2005
    ..Thirdly, fracture and fatigue properties of CNT/polymer nanocomposites are reviewed, since these properties are important, especially when these new nanocomposite materials are applied for structural applications...
  76. ncbi Design of braided composite cardiovascular catheters based on required axial, flexural, and torsional rigidities
    Jason Carey
    Department of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada T6G 2G8
    J Biomed Mater Res B Appl Biomater 70:73-81. 2004
  77. ncbi Mechanical properties and grindability of dental cast Ti-Nb alloys
    Masafumi Kikuchi
    Division of Dental Biomaterials, Graduate School of Dentistry, Tohoku University 4 1, Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8575 Japan
    Dent Mater J 22:328-42. 2003
    ..The Ti-30% Nb alloy exhibited significantly better grindability at low grinding speed with higher hardness, strength, and Young's modulus than titanium, presumably due to precipitation of the omega phase in the beta matrix...
  78. ncbi Numerical method to determine mechanical parameters of engineering design in rock masses
    Ting He Xue
    Traffic Engineering Institute, Zhejiang University, Hangzhou 310027, China
    J Zhejiang Univ Sci 5:884-9. 2004
    ..This method can be used to evaluate the mechanics of every kind of medium; and is a new way to determine the mechanical parameters used in engineering design in ..
  79. ncbi Glassy photomechanical liquid-crystal network actuators for microscale devices
    C L van Oosten
    Department of Chemistry and Chemical Engineering, Technische Universiteit Eindhoven, Postbus 513, 5600 MB Eindhoven, The Netherlands
    Eur Phys J E Soft Matter 23:329-36. 2007
    ..The bending radii of these systems are predicted using a simple model including effects of light intensity, material composition and actuator thickness...
  80. ncbi Electronic, thermal and mechanical properties of carbon nanotubes
    M S Dresselhaus
    Department of Physics and Department of Electrical Engineering and Computer Science, Massachussetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Philos Transact A Math Phys Eng Sci 362:2065-98. 2004
    ..Both experimental and theoretical aspects of these topics are reviewed...
  81. ncbi The contact mechanics of fractal surfaces
    Renato Buzio
    INFM Dipartimento di Fisica, Universita di Genova, Via Dodecaneso 33, 16146 Genova, Italy
    Nat Mater 2:233-6. 2003
    The role of surface roughness in contact mechanics is relevant to processes ranging from adhesion to friction, wear and lubrication...
  82. ncbi Effect of polymorphism of SiO2 addition on mechanical properties of Feldspathic porcelains
    Ryo Tokunaga
    General Dentistry Department of Comprehensive Oral Health Care, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Dent Mater J 27:347-55. 2008
    ..Circumferential cracks were observed in the porcelains with cristobalite. These results suggested that cristobalite could strengthen fracture toughness of feldspathic porcelains, but not flexural strength...
  83. ncbi Mechanics of patterned helical Si springs on Si substrate
    D L Liu
    Department of Physics, Applied Physics, and Astronomy, Rensselaer Polytechnic Institute, Troy, New York, USA
    J Nanosci Nanotechnol 3:492-5. 2003
  84. ncbi Mechanical properties of glass-ceramic A-W-polyethylene composites: effect of filler content and particle size
    J A Juhasz
    Department of Materials Science and Metallurgy, University of Cambridge, Cambridge CB2 3QZ, UK
    Biomaterials 25:949-55. 2004
    ..A transition in fracture behaviour from ductile to brittle behaviour was observed in samples containing between 30 and 40 vol% filler...
  85. ncbi Effect of novel filler particles on the mechanical and wear properties of dental composites
    D E Ruddell
    Curriculum in Applied and Materials Sciences, University of North Carolina, Chapel Hill, NC, USA
    Dent Mater 18:72-80. 2002
    ..The purpose of this study was to investigate the method of producing pre-polymerized fused-fiber filler modified composite (PP-FFMC) particles and the effectiveness of incorporating these novel filler particles into dental composites...
  86. ncbi Mechanical properties of cast Ti-Hf alloys
    Hideki Sato
    Division of Operative Dentistry, Graduate School of Dentistry, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Biomed Mater Res B Appl Biomater 72:362-7. 2005
    ..05) lower than that of the pure Ti. The cast Ti-Hf alloys tested can be considered viable alternatives to CP Ti because they were stronger than CP Ti and had similar elongation...
  87. ncbi Porous polymer/bioactive glass composites for soft-to-hard tissue interfaces
    Kai Zhang
    Department of Chemical Engineering and Materials Science, University of Minnesota, 421 Washington Avenue SE, Minneapolis, Minnesota 55455, USA
    J Biomed Mater Res 61:551-63. 2002
    ..Composite modulus and break strength increased with increasing glass content due to the change in composition and pore content...
  88. ncbi Mechanical properties and cellular proliferation of electrospun collagen type II
    Kelly J Shields
    Orthopedic Research Laboratory, Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia 23298 0694, USA
    Tissue Eng 10:1510-7. 2004
    ..Electrospun collagen type II scaffolds produce a suitable environment for chondrocyte growth, which potentially establishes the foundation for the development of articular cartilage repair...
  89. ncbi Progress on mechanics of carbon nanotubes and derived materials
    Jean Paul Salvetat
    CNRS, Centre de Recherche sur la Matiere Divisee, UMR6619, Orleans, France
    J Nanosci Nanotechnol 6:1857-82. 2006
    ..Nanotube surface engineering combined with methods producing oriented nanocomposites should bring exceptional materials in the near future...
  90. ncbi Remote sensing of mechanical properties of materials using a novel ultrasound transducer and signal processing
    Yoshinobu Murayama
    College of Engineering, Nihon University, Koriyama, Fukushima 963 8642, Japan
    IEEE Trans Ultrason Ferroelectr Freq Control 52:439-44. 2005
    ..Such measurements obviate the need to apply the force-deformation approach and may be used to enable stiffness imaging...
  91. ncbi Thermal and thermomechanical properties of poly(butylene succinate) nanocomposites
    Mamookho E Makhatha
    National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria 0001, PO Box 395, Republic of South Africa
    J Nanosci Nanotechnol 8:1679-89. 2008
    ..In the nitrogen environment, however, the thermal stability systematically decreases with increasing clay loading...
  92. ncbi Spider silk fibers spun from soluble recombinant silk produced in mammalian cells
    Anthoula Lazaris
    Nexia Biotechnologies, Vaudreuil Dorion, Quebec J7V 8P5, Canada
    Science 295:472-6. 2002
    ..Fiber properties correlated with finer fiber diameter and increased birefringence...
  93. ncbi The mechanics of the middle-ear at static air pressures: the role of the ossicular joints, the function of the middle-ear muscles and the behaviour of stapedial prostheses
    K B Huttenbrink
    HNO Universitätsklinik Münster, West Germany
    Acta Otolaryngol Suppl 451:1-35. 1988
    ..This mode of motion has been the generally accepted concept of the ossicle-chain mechanics up to now...
  94. ncbi Aerosolized diuretics for preterm infants with (or developing) chronic lung disease
    L P Brion
    Albert Einstein College of Medicine, Children s Hospital at Montefiore, Pediatrics, Section of Neonatology, Weiler Hospital Room 725, 1825 Eastchester Road, Bronx, NY 10461 2373, USA
    Cochrane Database Syst Rev 3:CD001694. 2006
    ..Lung disease in preterm infants is often complicated with lung edema...
  95. ncbi Helium-hyperoxia, exercise, and respiratory mechanics in chronic obstructive pulmonary disease
    Neil D Eves
    Rehabilitation Medicine, University of Calgary, Calgary, AB, Canada T2N 1N4
    Am J Respir Crit Care Med 174:763-71. 2006
    ..Combining these gases could have an additive effect on dynamic hyperinflation and a greater impact on respiratory mechanics and exercise tolerance.
  96. ncbi The impact of morbid obesity, pneumoperitoneum, and posture on respiratory system mechanics and oxygenation during laparoscopy
    Juraj Sprung
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Anesth Analg 94:1345-50. 2002
    ..20 mm Hg pneumoperitoneum, and body posture (30 degrees head down and 30 degrees head up) on respiratory system mechanics, oxygenation, and ventilation during laparoscopy...
  97. ncbi Alteration of skin mechanics by thin polymer films
    Janusz Jachowicz
    Better Cosmetics LLC, Bethel, CT 06801 2912, USA
    Skin Res Technol 14:312-9. 2008
    ..The aim of the study was to assess whether high molecular weight synthetic polymers, in the form of simple skin treatment formulations, could modify mechanical properties of natural skin as well as artificial skin models...
  98. ncbi Partial liquid ventilation with and without inhaled nitric oxide in a newborn piglet model of meconium aspiration
    K J Barrington
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Am J Respir Crit Care Med 160:1922-7. 1999
    ..effects of partial liquid ventilation (PLV) with and without inhaled nitric oxide (NO) over a 4-h period on lung mechanics, gas exchange, and hemodynamics in an animal model of meconium aspiration syndrome (MAS)...
  99. pmc Investigation of the mechanics of Type III stapes columella tympanoplasty using laser-Doppler vibrometry
    Wade Chien
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Otol Neurotol 28:782-7. 2007
    To investigate the middle ear mechanics of Type III stapes columella tympanoplasty using laser-Doppler vibrometry (LDV) and to determine whether LDV was useful in the identification of structural factors responsible for poor hearing ..
  100. ncbi Investigation of the mechanism of the cell wall DD-carboxypeptidase reaction of penicillin-binding protein 5 of Escherichia coli by quantum mechanics/molecular mechanics calculations
    Qicun Shi
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Am Chem Soc 130:9293-303. 2008
    ..This absence is addressed here by the use of explicit-solvent molecular dynamics simulations and ONIOM quantum mechanics/molecular mechanics (QM/MM) calculations...
  101. pmc The effect of postoperative passive motion on rotator cuff healing in a rat model
    Cathryn D Peltz
    McKay Orthopaedic Research Laboratory, University of Pennsylvania, 424 Stemmler Hall, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
    J Bone Joint Surg Am 91:2421-9. 2009 in an animal model of rotator cuff repair, and passive motion has been shown to improve joint mechanics in animal models of flexor tendon repair...

Research Grants71

  1. The influence of air pollution mixtures on biomarkers of airway oxidative stress
    Roby Greenwald; Fiscal Year: 2013
    ..Dr. Greenwald will also enroll in physiology and biochemistry courses examining the molecular and cellular mechanics of the respiratory response to inhaled toxicants and physiology courses pertaining to the respiratory and ..
  2. Neurotrophins in the Lung
    Y S Prakash; Fiscal Year: 2012
    ..molecular biology, immunocytochemistry, fluorescence Ca2+ imaging, force measurement techniques, and lung mechanics, we will focus on specific mechanisms that may be regulated by BDNF: the second messengers IP3 (via ..
  3. Novel Means to Establish Free Radical Balance in the Neonatal Premature Lung
    Prakash Jagtap; Fiscal Year: 2011
    ..on alveolarization, pulmonary vascular remodeling, interstitial inflammation, gas exchange, and pulmonary mechanics. To address this unmet need, we are developing R-100, a chemically stable redox agent formed from the covalent ..
  4. The Impact of Obstructive Sleep Apnea on Non-Alcoholic Fatty Liver Disease
    ..Corey will require additional training in study design, statistical analysis and obstructive sleep apnea mechanics. Dr. Corey will benefit from the guidance of her two co-mentors, Dr...
  5. PARP Inhibitor and Redox Catalyst for Ventilatory Trauma
    Prakash Jagtap; Fiscal Year: 2013
    ..A comparator group will be administered IV N-acetylcysteine (NAC) at an equivalent mass dose (30 mg/kg). Lung mechanics will be evaluated hourly, allowing for determination of: 1) dynamic respiratory system compliance, 2) resistance ..
  6. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2013
    ..During the mentored phase of this award I will learn new experimental skills in muscle mechanics and electrophysiology that will provide exciting results for the huge problem of preterm labor...
  7. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2012
    ..During the mentored phase of this award I will learn new experimental skills in muscle mechanics and electrophysiology that will provide exciting results for the huge problem of preterm labor...
  8. Clinical and genomic responses to remote ischemic preconditioning
    Brian W McCrindle; Fiscal Year: 2010
    ..of renal (urine output, urea, creatinine), cardiac (troponin I, inotrope score), pulmonary (pulmonary and airway mechanics, ventilation parameters), hematologic (blood counts), hepatic (transaminases, INR), metabolic (lactate, arterial ..
  9. Examination of the Final Stages of Platelet Production
    JONATHAN NOAH THON; Fiscal Year: 2013
    ..have provided me with the necessary expertise to meet my career goals by familiarizing me with the cytoskeletal mechanics, contribution of environmental factors such as extracellular matrix (ECM) components and shear forces, and the ..
    Robert Fettiplace; Fiscal Year: 2013
    ..Experiments will focus on transducer channel adaptation and hair bundle mechanics to define their regulation by Ca2+ and roles in frequency selectivity...
  11. Steroid-Based Contrast Agents for Magnetic Resonance Imaging of Endocrine Disease
    Thomas J Meade; Fiscal Year: 2013
    ..throughout a living organism is of vital importance as it allows for further understanding of cell signaling mechanics. Progesterone and estrogen are steroid hormones that bind to their receptors and function as a transcription ..
  12. Modulation of Ca Control of Cardiac Myofibrils
    R John Solaro; Fiscal Year: 2013
    ..impact of miR-208a KO on modifications of thin filament proteins, on myofilament response to Ca, on myocyte mechanics and Ca, and on in situ cardiac function. Aim #3...
  13. The Role of Lung Volumes in Nocturnal Asthma
    ROBERT LLEWELLYN OWENS; Fiscal Year: 2013
    ..His research efforts have focused on respiratory mechanics, with two projects to date resulting in first author publications...
  14. Mechanics and regulation of chromosome dynamics in meiotic prophase
    MICHAEL EDWARD DRESSER; Fiscal Year: 2012
    ..Understanding this new process will provide a new perspective to understand how chromosomes are prepared for inheritance and what makes chromosome transmission fail so frequently in humans. ..
  15. Reciprocal Control of Ca2+ Channels by Anchored Protein Kinase A and Calcineurin
    William A Sather; Fiscal Year: 2010
    ..The goal of the research plan is to gain substantial insight into the mechanics, at the molecular level, of modulation of CaV1.2 channel function...
  16. Mechanics of Inner Ear Hair Bundles
    ..These probes will be used to investigate stereocilia bundle mechanics, and (in subsequent projects) the micromechanics of transduction in cochlear hair cells...
  17. Skeletal muscle function and mitochondrial metabolism in non-diabetic CKD
    Baback Roshanravan; Fiscal Year: 2012
    ..During his investigation he will gain valuable insight in to muscle mechanics and energetics in collaboration with internationally renowned experts in muscle mechanics and metabolic imaging...
  18. Recombination Repair Complex in Human Cells
    Richard Fishel; Fiscal Year: 2013
    ..complex interactions of DSB repair components with chromatin and will provide additional insight into protein mechanics on chromosomes, chromosomal maintenance and ultimately rational therapeutic approaches to cancer and radiation ..
  19. Mechanisms Underlying the Progression of Arterial Stiffness in Hypertension
    Jay D Humphrey; Fiscal Year: 2013
    ..To test this hypothesis, we will quantify and compare for the first time progressive changes in wall mechanics, composition, and hemodynamics in 3 basic mouse models (wild-type, fibrillin-1 deficient, and fibulin-5 null), ..
  20. Epithelial JNK-TGFb1 Signaling Axis in Airway Remodeling
    Yvonne M W Janssen-Heininger; Fiscal Year: 2013
    ..of house dust mite-induced epithelial to mesenchymal transition, airways fibrosis, and altered respiratory mechanics in vivo, and utilize mice that globally lack JNK1, or specifically within the bronchiolar epithelium, following ..
  21. Molecular mechanics of mutant cardiac myosin
    Jeffrey R Moore; Fiscal Year: 2013
    ..This study will examine how FHC mutations in one of the proteins of the heart (the myosin regulatory light chain), alters the ability of the heart to generate force and power at the molecular level. ..
  22. Predicting cell deformation from body level mechanical loads
    Ahmet Erdemir; Fiscal Year: 2012
    ..mechanisms can be studied in an isolated fashion but connecting mechanical cellular response to organ level mechanics and human movement requires a multiscale approach...
  23. Middle-ear Mechanics in Normal and Pathological Ears
    John J Rosowski; Fiscal Year: 2013
    ..Over the past 10 years, we have utilized a unique and powerful combination of methods to study middle-ear mechanics including in-vivo measurements using laser Doppler vibrometry, in-vitro measurements in cadaveric human temporal ..
  24. Non-invasive Ultrasound Elasticity Imaging (UEI) in Crohn's Disease
    Jonathan M Rubin; Fiscal Year: 2010
    ..This method allows complete characterization of the altered local tissue elastic properties and local intestine mechanics. Furthermore, it does so with high spatial resolution, offering excellent sensitivity, specificity, accuracy and ..
  25. Integrated imaging of the form and function of the beating embryonic heart
    ANDREW MARTIN ROLLINS; Fiscal Year: 2013
    ..With an integrated imaging system that can capture contraction mechanics, hemodynamics, calcium transients, and electrical conduction throughout the developmental stages during which ..
  26. Computational Modeling and Accelerated Aging of the Ascending Aorta
    Jay D Humphrey; Fiscal Year: 2013
    ..e., the first open source finite element model capable of modeling the unique evolving histo-mechanics of the ascending aorta), and "pilot or feasibility studies" (i.e...
  27. Syndecan-1 in Aortic Aneurysm Formation
    Elliot Chaikof; Fiscal Year: 2012
    ..Specifically, we intend to: (1) determine the capacity of arterial wall mechanics and oxidized lipids, both as isolated and interactive factors, to modulate syndecan-1 expression during the ..
  28. The biomechanics of morphogenesis in the frog
    Lance A Davidson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The goal of this proposal is to apply a multi-scale analysis of the mechanics of convergent extension, identifying biomechanical mechanisms that regulate cell shape and drive mediolateral cell ..
  29. Nuclear mechanics and mechanotransduction in muscular laminopathies
    Jan Lammerding; Fiscal Year: 2013
    ..In the first aim, we will test the hypothesis that altered nuclear mechanics result in increased nuclear rupture in mechanically stressed tissue...
    R Dyche Mullins; Fiscal Year: 2013
    ..2. Use reconstituted lamellipodial actin networks to understand the biochemical basis of cytoskeletal mechanics and the crosstalk between signaling and the cytoskeleton...
  31. Structural Dynamics of Cardiac Muscle Contraction
    Brett A Colson; Fiscal Year: 2012
    ..His strong background in heart and skeletal muscle physiology, using methods of muscle fiber mechanics, x-ray diffraction, and molecular biology, will be augmented by training in spectroscopic probe techniques, ..
  32. Biomechanics of Blood Stream Infections
    John G Younger; Fiscal Year: 2012
    ..goal of this work is mechanically phenotype this material and to experimentally link these organisms'mechanics to behavior in vivo so as to better understand clinical device infections and their complications...
    Jay D Humphrey; Fiscal Year: 2010
    ..We submit that such quantification will be fundamental to many basic science and industrial studies seeking to improve vascular health. ..
  34. The Efficacy of Pranayama in COPD
    David A Kaminsky; Fiscal Year: 2013
    ..that the mechanisms involved will include reduced dynamic hyperinflation as well as beneficial effects on lung mechanics, inflammation and oxidative stress...
  35. Molecular control of tissue morphogenesis
    Jennifer A Zallen; Fiscal Year: 2013
    ..Recent work has provided insight into the physical mechanisms that underlie the mechanics of force generation and cell adhesion during axis elongation...
  36. Molecular roles in active and passive mechanics in cochlear hair bundles
    ANTHONY WEI PENG; Fiscal Year: 2013 micro-electro-mechanical systems (MEMS) devices are developed to specifically measure cochlear hair bundle mechanics. Using whole-cell voltage clamp recordings of mammalian cochlear hair cells along with new MEMS devices, ..
  37. Computational and Functional Characterization of the Molecular Steps in Membran*
    J Troy Littleton; Fiscal Year: 2013
    ..In particular, little is known about the detailed mechanics of protein interactions that regulate synaptic vesicle fusion...
  38. The Role of Age-Related Matrix Stiffening in Endothelial Cell Function
    Cynthia A Reinhart-King; Fiscal Year: 2012
    ..and monolayer permeability on varying stiffness substrates to test the hypothesis that changes in substrate mechanics alters endothelial cell morphology, focal adhesion formation, and junctional integrity...
  39. Genetics and Molecular Biology of Striated Muscle Myosin
    Sanford I Bernstein; Fiscal Year: 2013
    ..upon myosin structure, ATPase activity, in vitro motility, indirect flight and jump muscle ultrastructure, fiber mechanics and organism locomotion...
  40. Transforming Growth Factor-Beta Signal Transduction
    Joan Massague; Fiscal Year: 2013
    ..identified Smad proteins as receptor substrates and transcriptional regulators, and delineated the basic mechanics of Smad nuclear accumulation and target gene selection...
  41. Engineering Developmental Microenvironments: Cartilage Formation and Maturation
    Robert L Mauck; Fiscal Year: 2012
    ..Yet, the mechanics and ECM organization of engineered constructs for implantation have yet to match those of the native tissue and ..
  42. Image-based modeling of nonlinear and anisotropic intervertebral disc mechanics
    Edward J Vresilovic; Fiscal Year: 2010
    ..For over three decades finite element models have proved valuable to study disc mechanics. However, the currently available disc models have three significant limitations that will be addressed in this ..
  43. Novel Topoisomerase I Inhibitors
    MARK S CUSHMAN; Fiscal Year: 2013
    ..ternary complexes through medicinal chemistry, computer graphics molecular modeling, molecular mechanics, ab initio quantum mechanics, and biochemical studies...
  44. Single Cross-Bridge Kinetics in Transgenic Mouse Hearts Expressing FHC Mutations
    Danuta Szczesna-Cordary; Fiscal Year: 2012
    ..kinetics must be carried out at the level of a single cross-bridge and the results compared to cross-bridge mechanics derived from measurements on skinned and intact muscle fibers...
  45. Rac1 and Rac2 Guanosine Triphosphatases in Erythroid Function and Differentiation
    ..we propose a systematic characterization of the effects of Rac GTPase deficiency on the actin polymerization mechanics in the RBC cytoskeleton, with analysis of the actin-associated proteins and evaluation of possible cross-talk of ..
  46. Mechanisms of Mycoplasmal Disease Pathogenesis
    KEVIN F DYBVIG; Fiscal Year: 2013
    ..Knowledge of the structures will be instrumental in understanding the mechanism of their synthesis and the mechanics of how they interact with mycoplasmal proteins and host molecules...
  47. Effect of Prosthetic Foot-Ankle Stiffness on Amputee Function
    GLENN KLUTE; Fiscal Year: 2011
    ..Clinicians are well aware that foot stiffness strongly influences the mechanics of amputee gait and prescribe ESAR feet with manufacturer-identified stiffness levels based on body weight and ..
  48. Dyspnea on Exertion in Obesity: Effects of Exercise Training and Weight Loss
    Tony G Babb; Fiscal Year: 2013 which exercise training would be dramatically beneficial, or to obesity-related changes in respiratory mechanics, in which aggressive weight loss measures may be necessary before exercise training can be tolerated...
  49. Signaling pathways that mediate mammalian oocyte cortical mechanics
    Douglas N Robinson; Fiscal Year: 2013
    ..From a cellular mechanics standpoint, it is remarkable that this cell division occurs at all, as fluid dynamics would predict that the ..
  50. Development of a Low Cost, Real-time Biofeedback Gait Retraining System
    SAUNDERS WHITTLESEY; Fiscal Year: 2012
    ..improves outcomes, helps reduce the recurrence of injury, as well as the long term consequences of the abnormal mechanics, such as osteoarthritis, and can reduce or even eliminate pain...
  51. Epigenetics participate in neonatal CLD
    Kurt H Albertine; Fiscal Year: 2013
    ..dysregulation caused by MV alone on pulmonary epigenetics, histology, respiratory gas exchange, and pulmonary mechanics. Specific Aim 1 will determine whether MV causes genome-wide dysregulation of H3 covalent modifications and DNA ..
  52. Assessing and modifying bone quality in chronic kidney disease
    Chris Newman; Fiscal Year: 2013
    ..include tissue-level mechanical properties, mineralization, collagen composition (cross-linking, morphology, and mechanics), and bone matrix hydration (MRI)...
  53. CRCNS:US French Coll:Computational Imaging of the Aging Cerebral Microvasculature
    Bradley P Sutton; Fiscal Year: 2013
    ..will be integrated into undergraduate and graduate course offerings by the research team, including: Modeling Human Physiology, Modeling Human Physiology Lab, Cellular Bioenergetics, and other fluid mechanics and mass transport courses.
  54. Biological Mechanism of FSGS-1
    Martin R Pollak; Fiscal Year: 2011
    ..of this protein and cause a ~10-fold increase in its actin-binding activity, leading to altered dynamics and mechanics of in vitro actin cytoskeletal networks...
  55. A TG model for functional effects of FHC mutations in b-cardiac myosin
    Susan Lowey; Fiscal Year: 2013
    ..Approaches ranging from single molecule mechanics to cardiac muscle physiology have led to the hypothesis that a "gain of function" arises from FH mutations in ..
  56. Regulation of Myosin Ic Mechanochemistry
    Michael J Greenberg; Fiscal Year: 2012
    ..Thus, by understanding the mechanics of myosin Ic, the molecular role of myosin Ic can be deduced...
  57. Mechanisms of rapid paravascular fluid transport in the brain
    Jeffrey J Iliff; Fiscal Year: 2012
    ..However, the mechanics and molecular basis of this paravascular fluid transport remain poorly characterized...
  58. Structural origin of fibrin clot mechanical properties
    John W Weisel; Fiscal Year: 2012
    ..To build a general theory of the structural origin of clot mechanics, we will develop constitutive models that take advantage of the quantitative information derived from ..
  59. Cardiac Imaging of Thoracic Fat and Aortic Stiffness in Older High Risk Patients
    Tina E Brinkley; Fiscal Year: 2013
    ..Receipt of this K01 award will provide training in imaging, epidemiology, and vascular biology/mechanics, thereby equipping her with the skills necessary to become an independent researcher in the field of ..
  60. 3-D optical imaging of the in vivo organ of Corti motion at a sub-nanometer scale
    Alfred L Nuttall; Fiscal Year: 2013
    ..Knowledge of the in vivo mechanics of the tectorial membrane, including resonance, will set to rest a quarter century of conjecture on how the ..
  61. Structure, Activity &Physiological Role of Hemichannels
    Ratneshwar Lal; Fiscal Year: 2012
    ..complex, resulting 3D conformations and channel properties such as permeability, conductance, energetics, and mechanics. The main focus of this application is two-fold: a) to have a practical integrated double chamber AFM with the ..
  62. In Vivo Imaging-Based Multiscale Modeling of Normal and Atrophied Human Lower Leg
    Shantanu Sinha; Fiscal Year: 2013
    ..It is now evident that complex intramuscular mechanics play a critical role in the muscle forces generated in active muscles...
    CLAIRE FARLEY; Fiscal Year: 2000
    ..Experimental findings on the mechanics of running gaits have revealed that the overall musculoskeletal system behaves like a single linear spring in ..
  64. Bioengineering Studies of Abdominal Aortic Aneurysm Fluid and Wall Dynamics
    ENDER FINOL; Fiscal Year: 2009
    ..potential is the non-uniform arterial wall thickness, within the context of a dynamic assessment of aneurysm mechanics. Our overall goal is to address this hypothesis by predicting AAA risk of rupture on a patient-specific basis ..
    Julius Guccione; Fiscal Year: 1999
    ..these passive material properties will be used in an existing state-of-the-art finite element model for the mechanics of the beating ventricles to compute three-dimensional myocardial stress and deformation throughout the ..
    Robert Kusy; Fiscal Year: 2002
    ..During treatment these patients will likely require some space closure or regaining via sliding mechanics. Unfortunately the uncertainty of frictional forces complicates the practitioner's best efforts to move teeth...
    Julian Allen; Fiscal Year: 1992
    ..It results in multiple abnormalities of lung mechanics, e.g., decreased lung compliance and increased airway resistance and work of breathing...
  68. Histo-Mechanics & Biology of Remodeling in Hypertension
    JAY HUMPHREY; Fiscal Year: 2005
    ..Recent advances in vascular biology and mechanics suggest a paradigm shift in hypertension research...
    JEFFRY MADURA; Fiscal Year: 2002
    ..For example molecular mechanics/dynamics will be used to investigate the binding of polysaccharides to Chitinase A while coupled quantum ..
  70. Ventilation Improves Lung Physiology and Biology
    Bela Suki; Fiscal Year: 2006
    ..tidal volume (Vt) and frequency on a cycle by cycle basis, called variable ventilation(VV), improves both lung mechanics and oxygenation in a rodent model of acute lung injury...
    Ajit Yoganathan; Fiscal Year: 1992
    The faculty of the Cardiovascular Fluid Mechanics Laboratory at the Georgia Institute of Technology propose the acquisition of new research equipment to allow for state-of-the-art velocity measurement visualization in cardiovascular flow ..