magnetics

Summary

Summary: The study of magnetic phenomena and magnetic fields. Magnetism produced by electric currents is ELECTROMAGNETICS.

Top Publications

  1. pmc Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy
    Keir C Neuman
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, 50 South Drive, Bethesda, Maryland 20892, USA
    Nat Methods 5:491-505. 2008
  2. ncbi Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging
    Y X Wang
    Department of Radiology, Erasmus University Medical Center-Dijkzigt, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Eur Radiol 11:2319-31. 2001
  3. ncbi Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
    Mukesh G Harisinghani
    Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 348:2491-9. 2003
  4. ncbi Reconstruction of conductivity and current density images using only one component of magnetic field measurements
    Jin Keun Seo
    Department of Mathematics, Yonsei University, Seoul 120 749, Korea
    IEEE Trans Biomed Eng 50:1121-4. 2003
  5. pmc Size, charge and concentration dependent uptake of iron oxide particles by non-phagocytic cells
    Daniel L J Thorek
    Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, PA 19104, USA
    Biomaterials 29:3583-90. 2008
  6. pmc Magnetic tweezers: micromanipulation and force measurement at the molecular level
    Charlie Gosse
    Laboratoire de Physique Statistique, Ecole Normale Superieure, Unité de Recherche 8550 associée au Centre National de la Recherche Scientifique et aux Universités Paris VI et VII, 75231 Paris, France
    Biophys J 82:3314-29. 2002
  7. pmc Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors
    Beata Chertok
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109 1065, USA
    Biomaterials 29:487-96. 2008
  8. ncbi Locoregional cancer treatment with magnetic drug targeting
    C Alexiou
    Department of Otorhinolaryngology, Head and Neck Surgery, Klinikum rechts der Isar, Technical University of Munich, Germany
    Cancer Res 60:6641-8. 2000
  9. ncbi Cell shape and plasma membrane alterations after static magnetic fields exposure
    A Chionna
    Dept of Biological and Environmental Science and Technology, University of Lecce, Italy
    Eur J Histochem 47:299-308. 2003
  10. ncbi Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo
    F Scherer
    Technische Universitat Munchen, Institute of Experimental Oncology, Munich, Germany
    Gene Ther 9:102-9. 2002

Detail Information

Publications385 found, 100 shown here

  1. pmc Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy
    Keir C Neuman
    Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, 50 South Drive, Bethesda, Maryland 20892, USA
    Nat Methods 5:491-505. 2008
    ..The most common force spectroscopy techniques are optical tweezers, magnetic tweezers and atomic force microscopy. Here we describe these techniques and illustrate them with examples highlighting current capabilities and limitations...
  2. ncbi Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging
    Y X Wang
    Department of Radiology, Erasmus University Medical Center-Dijkzigt, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Eur Radiol 11:2319-31. 2001
    ..Iron oxide particles for bowel contrast are coated with insoluble material, and all iron oxide particles for intravenous injection are biodegradable. Superparamagnetic agents open up an important field for research in MR imaging...
  3. ncbi Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
    Mukesh G Harisinghani
    Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 348:2491-9. 2003
    ....
  4. ncbi Reconstruction of conductivity and current density images using only one component of magnetic field measurements
    Jin Keun Seo
    Department of Mathematics, Yonsei University, Seoul 120 749, Korea
    IEEE Trans Biomed Eng 50:1121-4. 2003
    ..In our new MRCDI technique, we need to measure only one component of the induced magnetic flux density and reconstruct both cross-sectional conductivity and current density images without any subject rotation...
  5. pmc Size, charge and concentration dependent uptake of iron oxide particles by non-phagocytic cells
    Daniel L J Thorek
    Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, PA 19104, USA
    Biomaterials 29:3583-90. 2008
    ..Our results show that an unconventional highly cationic particle configuration at 107nm maximized MR contrast of T cells, outperforming the widely utilized USPIO (<50nm)...
  6. pmc Magnetic tweezers: micromanipulation and force measurement at the molecular level
    Charlie Gosse
    Laboratoire de Physique Statistique, Ecole Normale Superieure, Unité de Recherche 8550 associée au Centre National de la Recherche Scientifique et aux Universités Paris VI et VII, 75231 Paris, France
    Biophys J 82:3314-29. 2002
    ..From those experiments, we conclude that magnetic tweezers represent a low-cost and biocompatible setup that could become a suitable alternative to the other available micromanipulators...
  7. pmc Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors
    Beata Chertok
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109 1065, USA
    Biomaterials 29:487-96. 2008
    ..Hence, these nanoparticles appear to be a promising vehicle for glioma-targeted drug delivery...
  8. ncbi Locoregional cancer treatment with magnetic drug targeting
    C Alexiou
    Department of Otorhinolaryngology, Head and Neck Surgery, Klinikum rechts der Isar, Technical University of Munich, Germany
    Cancer Res 60:6641-8. 2000
    ..Furthermore, it may be possible to use these magnetic particles as a "carrier system" for a variety of anticancer agents, e.g., radionuclides, cancer-specific antibodies, and genes...
  9. ncbi Cell shape and plasma membrane alterations after static magnetic fields exposure
    A Chionna
    Dept of Biological and Environmental Science and Technology, University of Lecce, Italy
    Eur J Histochem 47:299-308. 2003
    ..Here we report data that support biological effects of static MFs on U937 cells and human lymphocytes. However, the involvement of these modifications in the onset of diseases needs to be further elucidated...
  10. ncbi Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo
    F Scherer
    Technische Universitat Munchen, Institute of Experimental Oncology, Munich, Germany
    Gene Ther 9:102-9. 2002
    ..Magnetofection provides a novel tool for high throughput gene screening in vitro and can help to overcome fundamental limitations to gene therapy in vivo...
  11. ncbi Cytotoxicity suppression and cellular uptake enhancement of surface modified magnetic nanoparticles
    Ajay Kumar Gupta
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Biomaterials 26:1565-73. 2005
    ....
  12. ncbi Antitumour drugs impede DNA uncoiling by topoisomerase I
    Daniel A Koster
    Kavli Institute of Nanoscience, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands
    Nature 448:213-7. 2007
    ..This combination of single-molecule and in vivo data suggests a cytotoxic mechanism for camptothecins, in which the accumulation of positive supercoils ahead of the replication machinery induces potentially lethal DNA lesions...
  13. ncbi The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma
    Andreas Jordan
    Center of Biomedical Nanotechnology CBN, c o Department of Radiology, CVK, Charite University Medicine, Berlin, Germany
    J Neurooncol 78:7-14. 2006
    ..The optimal treatment schedules and potential combinations with other therapies need to be defined in further studies...
  14. pmc Nearly complete regression of tumors via collective behavior of magnetic nanoparticles in hyperthermia
    C L Dennis
    Materials Science and Engineering Laboratory, NIST, Gaithersburg, MD 20899 8552, USA
    Nanotechnology 20:395103. 2009
    ....
  15. pmc Detection and quantification of magnetically labeled cells by cellular MRI
    Wei Liu
    Philips Research North America, Briarcliff Manor, NY 10510, USA
    Eur J Radiol 70:258-64. 2009
    ..This review summarizes the practical issues regarding detection and quantification of magnetically labeled cells with various MRI contrast agents with a focus on SPIO nanoparticles...
  16. ncbi Magnetic tweezers measurement of single molecule torque
    Alfredo Celedon
    Department of Mechanical Engineering, Howard Hughes Medical Institute Graduate Training Program and Institute for NanoBioTechnology, Johns Hopkins University, Baltimore Maryland 21218, USA
    Nano Lett 9:1720-5. 2009
    ..We show torque measurement of single DNA molecules and demonstrate for the first time measurements of single chromatin fibers...
  17. ncbi Tomographic imaging using the nonlinear response of magnetic particles
    Bernhard Gleich
    Philips Research Hamburg, Röntgenstrasse 24 26, D 22335 Hamburg, Germany
    Nature 435:1214-7. 2005
    ..We evaluate the prospects for further improvement, and show that the method has the potential to be developed into an imaging method characterized by both high spatial resolution as well as high sensitivity...
  18. ncbi Direct observation of dipolar chains in iron ferrofluids by cryogenic electron microscopy
    K Butter
    Van t Hoff Laboratory for Physical and Colloid Chemistry, Debye Institute, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Nat Mater 2:88-91. 2003
    ..These findings show that the experimental model used is well suited to study the structural properties of dipolar particle systems...
  19. pmc Changing and shielded magnetic fields suppress c-Fos expression in the navigation circuit: input from the magnetosensory system contributes to the internal representation of space in a subterranean rodent
    Tomás Burger
    Department of Zoology, Faculty of Science Charles University in Prague, Vinicna 7, CZ 12844 Praha 2, Czech Republic
    J R Soc Interface 7:1275-92. 2010
    ..Thus, magnetic information may be integrated with multimodal sensory and motor information into a common spatial representation of allocentric space within this circuit...
  20. ncbi The biotin-streptavidin interaction can be reversibly broken using water at elevated temperatures
    Anders Holmberg
    Department of Biotechnology, Royal Institute of Technology KTH, Stockholm, Sweden
    Electrophoresis 26:501-10. 2005
    ....
  21. ncbi Doxorubicin loaded magnetic polymersomes: theranostic nanocarriers for MR imaging and magneto-chemotherapy
    Charles Sanson
    Université de Bordeaux IPB, ENSCBP, 16 Avenue Pey Berland, 33607 Pessac Cedex, France
    ACS Nano 5:1122-40. 2011
    ..These magnetic polymersomes can be used as efficient multifunctional nanocarriers for combined therapy and imaging...
  22. ncbi Magnetic biosensor technologies for medical applications: a review
    J Llandro
    Cavendish Laboratory, Cambridge, UK
    Med Biol Eng Comput 48:977-98. 2010
    ..Finally, progress in the field of magnetic biosensors and the outlook for the future are discussed...
  23. ncbi Smart drug delivery through DNA/magnetic nanoparticle gates
    Eduardo Ruiz-Hernández
    Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s n, 28040 Madrid, Spain
    ACS Nano 5:1259-66. 2011
    ..Furthermore, due to its capacity to increase the temperature of the surrounding media, this multifunctional device could play an important role in the development of advanced drug delivery systems for thermochemotherapy against cancer...
  24. ncbi Multiferroics with spiral spin orders
    Yoshinori Tokura
    Department of Applied Physics, University of Tokyo, Multiferroics Project, ERATO, Japan Science and Technology Agency, Tokyo, Japan
    Adv Mater 22:1554-65. 2010
    ....
  25. ncbi Rolled-up magnetic sensor: nanomembrane architecture for in-flow detection of magnetic objects
    Ingolf Mönch
    Institute for Integrative Nanosciences, IFW Dresden, Helmholtzstrasse 20, 01069 Dresden, Germany
    ACS Nano 5:7436-42. 2011
    ..The performance of the rolled-up magnetic sensor for the in-flow detection of ferromagnetic CrO(2) nanoparticles embedded in a biocompatible polymeric hydrogel shell is highlighted...
  26. pmc Magnetoreception in an avian brain in part mediated by inner ear lagena
    Le Qing Wu
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Biol 21:418-23. 2011
    ..We also found, through ablation studies, that much of the observed pathway appears to receive magnetic information from the pigeon lagena receptor organs...
  27. ncbi Static magnetic fields aggravate the effects of ionizing radiation on cell cycle progression in bone marrow stem cells
    Amir Sabet Sarvestani
    Department of Biophysics, Faculty of Bioscience, Tarbiat Modares University, Tehran, Iran
    Micron 41:101-4. 2010
    ....
  28. ncbi Human erythrocytes as nanoparticle carriers for magnetic particle imaging
    D E Markov
    Philips Research Europe, High Tech Campus 4, 5656 AE Eindhoven, The Netherlands
    Phys Med Biol 55:6461-73. 2010
    ..This affects the MPI signal of an erythrocyte-based tracer, compared to bulk. The reduced signal is counterbalanced by a higher in vivo stability of the SPIO-loaded RBCs constructs for MPI applications...
  29. ncbi Impact of magnetic labeling on human and mouse stem cells and their long-term magnetic resonance tracking in a rat model of Parkinson disease
    Albrecht Stroh
    Institute of Neuroscience, Technical University Munich, Munich, Germany
    Mol Imaging 8:166-78. 2009
    ..Our study strongly suggests that molecular MRI approaches must be carefully tailored to the respective cell population to exert minimal physiologic impact, ensuring the feasibility of this imaging approach for clinical applications...
  30. ncbi Quick genotyping detection of HBV by giant magnetoresistive biochip combined with PCR and line probe assay
    Xiao Zhi
    National Key Laboratory of Nano Micro Fabrication Technology, Institute of Micro Nano Science and Technology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    Lab Chip 12:741-5. 2012
    ..The novel method has great potential application in clinical HBV genotyping diagnosis, and can be easily extended to other biomedical applications based on molecular recognition...
  31. pmc Effects of low-field magnetic stimulation on brain glucose metabolism
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, MD 20892, USA
    Neuroimage 51:623-8. 2010
    ..This data provides preliminary evidence that EPI sequences may affect neuronal activity and merits further investigation...
  32. ncbi A novel calcium phosphate ceramic-magnetic nanoparticle composite as a potential bone substitute
    Yao Wu
    National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, People s Republic of China
    Biomed Mater 5:15001. 2010
    ..Accordingly, it might be expected that this CaP-MNP composite could become a potential bone substitute or bone tissue engineering scaffold...
  33. ncbi Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite
    Anna Tampieri
    Institute of Science and Technology for Ceramics National Research Council, Faenza RA 48018, Italy
    Acta Biomater 8:843-51. 2012
    ..This result potentially opens new perspectives for biodevices aimed at bone regeneration and for anti-cancer therapies based on hyperthermia...
  34. ncbi The use of magnets with single-site umbilical laparoscopic surgery
    Benjamin E Padilla
    Department of Surgery, Fundación Hospitalaria Children s Hospital, Buenos Aires, Argentina
    Semin Pediatr Surg 20:224-31. 2011
    ..Magnet-assisted laparoscopic surgery is safe and effective in children. The use of magnetic graspers improves triangulation and ergonomics while reducing the number and size of abdominal incisions...
  35. ncbi Synthesis, functionalization, and biomedical applications of multifunctional magnetic nanoparticles
    Rui Hao
    Department of Advanced Materials and NanotechnologyPeking University, Beijing, People s Republic of China
    Adv Mater 22:2729-42. 2010
    ..It also summarizes the general strategies applied for NP surface functionalization. The review further highlights some exciting examples of these MFMNPs for multimodality imaging and for target-specific drug/gene delivery applications...
  36. ncbi Microfluidic assisted synthesis of multi-functional polycaprolactone microcapsules: incorporation of CdTe quantum dots, Fe3O4 superparamagnetic nanoparticles and tamoxifen anticancer drugs
    C H Yang
    Dept of Biological Science and Technology, I Shou University, Taiwan
    Lab Chip 9:961-5. 2009
    ..The result showed superparamagnetic and fluorescent properties, and was used as a controlled drug release vehicle. The composite magnetic and fluorescent PCL microcapsules are potential candidates for a smart drug delivery system...
  37. ncbi Recent advances in magnetic tweezers
    Iwijn De Vlaminck
    Kavli Institute of Nanoscience, Delft University of Technology, Delft, 2628 CJ, The Netherlands
    Annu Rev Biophys 41:453-72. 2012
    ..In this review, we survey the most important recent advances and reflect on more interesting twists to come...
  38. ncbi Feasibility and safety of remote-controlled magnetic navigation for ablation of atrial fibrillation
    William T Katsiyiannis
    Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA
    Am J Cardiol 102:1674-6. 2008
    ..In conclusion, radiofrequency ablation of AF performed with RMN is safe and feasible. Compared with conventional hand-navigated ablation, RMN ablation results in similar clinical outcomes with decreased fluoroscopy and procedure times...
  39. ncbi Inhibited atherosclerotic plaque formation by local administration of magnetically labeled endothelial progenitor cells (EPCs) in a rabbit model
    Zhan Long Ma
    Department of Radiology, Molecular Imaging Laboratory, Zhong Da Hospital, Southeast University, Nanjing, China
    Atherosclerosis 205:80-6. 2009
    ..To investigate whether atherosclerosis can be prevented by magnetically labeled endothelial progenitor cells (EPCs) in rabbits...
  40. ncbi Giant magnetoresistive sensors and superparamagnetic nanoparticles: a chip-scale detection strategy for immunosorbent assays
    Rachel L Millen
    Department of Chemistry, Ames Laboratory USDOE, and Institute for Combinatorial Discovery, Iowa State University, Ames, Iowa 50011, USA
    Anal Chem 77:6581-7. 2005
    ..These results, along with a detailed description of the experimental testing platform, are described in terms of sensitivity, detection limits, and potential for multiplexing...
  41. ncbi Quaternion-based extended Kalman filter for determining orientation by inertial and magnetic sensing
    Angelo M Sabatini
    ARTS Lab, Scuola Superiore Sant Anna, Piazza Martiri della Libertà, Pisa 56127, Italy
    IEEE Trans Biomed Eng 53:1346-56. 2006
    ....
  42. ncbi Wavelength-dependent effects of light on magnetic compass orientation in Drosophila melanogaster
    J B Phillips
    Department of Biology, Indiana University, Bloomington 47405
    J Comp Physiol A 172:303-8. 1993
    ..However, the data do not exclude the alternative hypothesis that a change in the wavelength of light has a non-specific effect on the flies' behavior, i.e., causing the flies to exhibit a different form of magnetic orientation behavior...
  43. ncbi AC-magnetic field controlled drug release from magnetoliposomes: design of a method for site-specific chemotherapy
    M Babincova
    Department of Biophysics and Chemical Physics, Comenius University, Mlynska dolina F1, 842 48 Bratislava, Slovakia
    Bioelectrochemistry 55:17-9. 2002
    ..The results showed that magnetoliposomes could be specifically heated to 42 degrees C (phase transition temperature of a used lipid) in a few minutes and during this, the encapsulated doxorubicin is massively released...
  44. ncbi Clinical applications of magnetic nanoparticles for hyperthermia
    Burghard Thiesen
    MagForce Nanotechnologies AG, Berlin, Germany
    Int J Hyperthermia 24:467-74. 2008
    ..Numerous groups are working in this field worldwide, but only one approach has been tested in clinical trials so far. Here, we summarize the clinical data gained in these studies on magnetic fluid induced hyperthermia...
  45. ncbi Chondrogenic differentiation of mesenchymal stem cells is inhibited after magnetic labeling with ferumoxides
    Jeff W M Bulte
    Blood 104:3410-2; author reply 3412-3. 2004
  46. ncbi Symmetry breaking in a plasmonic metamaterial at optical wavelength
    André Christ
    Nanophotonics and Metrology Laboratory, Ecole Polytechnique Federal de Lausanne, Lausanne, Switzerland
    Nano Lett 8:2171-5. 2008
    ..Such higher order plasmon resonances are characterized by their subradiant nature. They generally reveal long lifetimes and distinct absorption losses. It is shown that the near-field interaction strongly determines these modes...
  47. ncbi Clinical hyperthermia of prostate cancer using magnetic nanoparticles: presentation of a new interstitial technique
    M Johannsen
    Department of Urology, Charite Campus Mitte, Schumannstr 20 21, 10117 Berlin, Germany
    Int J Hyperthermia 21:637-47. 2005
    ..To the authors' knowledge, this is the first report on clinical application of interstitial hyperthermia using magnetic nanoparticles in the treatment of human cancer...
  48. ncbi Polarized light cues underlie compass calibration in migratory songbirds
    Rachel Muheim
    Department of Animal Ecology, Lund University, Ecology Building, SE 223 62 Lund, Sweden
    Science 313:837-9. 2006
    ..We suggest that skylight polarization patterns are used to derive an absolute (i.e., geographic) directional system that provides the primary calibration reference for all of the compasses of migratory songbirds...
  49. ncbi Anticancer effect and immune induction by hyperthermia of malignant melanoma using magnetite cationic liposomes
    Masataka Suzuki
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya, Japan
    Melanoma Res 13:129-35. 2003
    ..These results suggest that hyperthermia using MCLs is an effective therapy for melanoma, since this treatment can kill the tumour cells not only by heat but also by inducing an immune response...
  50. ncbi Magnetically enhanced nucleic acid delivery. Ten years of magnetofection-progress and prospects
    Christian Plank
    Institute of Experimental Oncology and Therapy Research, Technische Universitat Munchen, Munich, Germany
    Adv Drug Deliv Rev 63:1300-31. 2011
    ..We summarize results that have been obtained with using magnetofection in basic research and in preclinical animal models. Finally, we describe some of our recent work and end with some conclusions and perspectives...
  51. pmc Magnetic compass of birds is based on a molecule with optimal directional sensitivity
    Thorsten Ritz
    Department of Physics and Astronomy, University of California, Irvine, California, USA
    Biophys J 96:3451-7. 2009
    ..This radical pair design might be realized by cryptochrome photoreceptors if paired with molecular oxygen as a reaction partner...
  52. ncbi Biomolecular reactions studied using changes in Brownian rotation dynamics of magnetic particles
    Andrea Prieto Astalan
    IMEGO AB, Arvid Hedvalls Backe 4, SE 411 33 Göteborg, Sweden
    Biosens Bioelectron 19:945-51. 2004
    ..Our method allows to perform an immunoassay in a single step and is much faster and cheaper compared to conventional ELISA procedures...
  53. pmc A magnetically triggered composite membrane for on-demand drug delivery
    Todd Hoare
    Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L7, Canada
    Nano Lett 9:3651-7. 2009
    ..The total drug dose delivered was directly proportional to the duration of the "on" pulse. The membranes were noncytotoxic, were biocompatible, and retained their switchable flux properties after 45 days of subcutaneous implantation...
  54. pmc Avian ultraviolet/violet cones identified as probable magnetoreceptors
    Christine Niessner
    Fachbereich Biowissenschaften der J W Goethe Universität Frankfurt, Frankfurt am Main, Germany
    PLoS ONE 6:e20091. 2011
    ..But so far, the exact subcellular characterization of these molecules in the retina remained unknown...
  55. ncbi Static and ELF magnetic fields induce tumor growth inhibition and apoptosis
    S Tofani
    Department of Medical Physics, Ivrea Hospital ASL n 9, Ivrea TO, Italy
    Bioelectromagnetics 22:419-28. 2001
    ..A discussion on the possible biophysical mechanism at the base of the observed biological results is also offered...
  56. ncbi Enrichment of peptides in serum by C(8)-functionalized magnetic nanoparticles for direct matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis
    Ning Yao
    Department of Chemistry, Fudan University, Shanghai 200433, China
    J Chromatogr A 1185:93-101. 2008
    ..Finally, the C(8)-magnetic nanoparticles were successfully applied to fast and efficient enrichment of low-abundance peptides from protein tryptic digestion and human serum followed by MALDI-TOF-MS analysis...
  57. ncbi Three-dimensional distribution of the electric field induced in the brain by transcranial magnetic stimulation using figure-8 and deep H-coils
    Yiftach Roth
    Advanced Technology Center, Sheba Medical Center, Tel Hashomert, Israel
    J Clin Neurophysiol 24:31-8. 2007
    ....
  58. ncbi Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging
    Jae Hyun Lee
    Department of Chemistry and Nanomedical National Core Research Center, Yonsei University, Seoul 120 749, Korea
    Nat Med 13:95-9. 2007
    ..Also, we successfully visualized small tumors implanted in a mouse. Such high-performance, nanotechnology-based molecular probes could enhance the ability to visualize other biological events critical to diagnostics and therapeutics...
  59. ncbi Novel, magnetically guided catheter for endocardial mapping and radiofrequency catheter ablation
    Mitchell N Faddis
    Washington University School of Medicine, St Louis, MO, USA
    Circulation 106:2980-5. 2002
    ..A feasibility study was performed in animals to evaluate a novel magnetic guidance system (MGS) that generates a magnetic field to control the movement and position of a magnetic ablation catheter...
  60. ncbi Remote-controlled catheter ablation of accessory pathways: results from the magnetic laboratory
    Julian Kyoung Ryul Chun
    Department of Cardiology, Asklepios Klinik St Georg Hospital, Lohmuehlenstr 5, Hamburg 20099, Germany
    Eur Heart J 28:190-5. 2007
    ..This study evaluates feasibility, safety, and efficacy of magnetic remote-controlled accessory pathway (AP) ablation...
  61. ncbi Magnetic relaxation switches capable of sensing molecular interactions
    J Manuel Perez
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02129
    Nat Biotechnol 20:816-20. 2002
    ....
  62. pmc Magnetic field changes activate the trigeminal brainstem complex in a migratory bird
    Dominik Heyers
    Arbeitsgruppe Neurosensorik Animal Navigation, Institut für Biologie und Umweltwissenschaften, University of Oldenburg, D 26111 Oldenburg, Germany
    Proc Natl Acad Sci U S A 107:9394-9. 2010
    ..We therefore suggest that V1 transmits magnetic information to the brain in this migratory passerine bird...
  63. ncbi Resonance effects indicate a radical-pair mechanism for avian magnetic compass
    Thorsten Ritz
    Department of Physics and Astronomy, University of California, Irvine, California 92697 4575, USA
    Nature 429:177-80. 2004
    ..These results are consistent with a resonance effect on singlet-triplet transitions and suggest a magnetic compass based on a radical-pair mechanism...
  64. pmc Quantitative modeling and optimization of magnetic tweezers
    Jan Lipfert
    Kavli Institute of Nanoscience, Delft University of Technology, Delft, The Netherlands
    Biophys J 96:5040-9. 2009
    ..Following these principles, we present a configuration that allows one to apply > or = 40 pN stretching forces on approximately 1-microm tethered beads...
  65. ncbi Synthesis, properties, and applications of iron nanoparticles
    Dale L Huber
    Nanostructures and Advanced Materials Chemistry Dept Sandia National Laboratories, PO Box 5800 MS 1421, Albuquerque, NM 87185, USA
    Small 1:482-501. 2005
    ..Iron however has a great deal to offer at the nanoscale, including very potent magnetic and catalytic properties. Recent work has begun to take advantage of iron's potential, and work in this field appears to be blossoming...
  66. ncbi Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells
    J W Bulte
    Laboratory of Diagnostic Radiology Research CC, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Biotechnol 19:1141-7. 2001
    ..The availability of magnetodendrimers opens up the possibility of MR tracking of a wide variety of (stem) cell transplants...
  67. doi Drug-loaded superparamagnetic iron oxide nanoparticles for combined cancer imaging and therapy in vivo
    Mi Kyung Yu
    Research Center for Biomolecular Nanotechnology, Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryong dong, Buk Gu, Gwangju 500 712, South Korea
    Angew Chem Int Ed Engl 47:5362-5. 2008
  68. ncbi Dexamethasone-containing PLGA superparamagnetic microparticles as carriers for the local treatment of arthritis
    Nicoleta Butoescu
    School of Pharmaceutical Sciences, University of Geneva, Switzerland
    Biomaterials 30:1772-80. 2009
    ..This type of carrier could represent a suitable magnetically retainable intra-articular drug delivery system for treating joint diseases such as arthritis or osteoarthritis...
  69. ncbi Magnetic resonance tracking of magnetically labeled autologous bone marrow CD34+ cells transplanted into the spinal cord via lumbar puncture technique in patients with chronic spinal cord injury: CD34+ cells' migration into the injured site
    Fernando Callera
    Serviço de Hematologia e Hemoterapia de São José dos Campos, São José dos Campos São Paulo, CEP 12210 040, Brasil
    Stem Cells Dev 16:461-6. 2007
    ..We suggested for the first time that autologous bone marrow CD34(+) cells labeled with magnetic nanoparticles delivered into the spinal cord via LP technique migrated into the injured site in patients with chronic SCI...
  70. ncbi Robotic magnetic navigation for atrial fibrillation ablation
    Carlo Pappone
    Department of Electrophysiology, San Raffaele Scientific Institute, Milan, Italy
    J Am Coll Cardiol 47:1390-400. 2006
    ..We assessed feasibility of magnetic catheter guidance in patients with atrial fibrillation (AF) undergoing circumferential pulmonary vein ablation (CPVA)...
  71. ncbi Intracranial thermotherapy using magnetic nanoparticles combined with external beam radiotherapy: results of a feasibility study on patients with glioblastoma multiforme
    Klaus Maier-Hauff
    Department of Neurosurgery, Bundeswehrkrankenhaus, Berlin, Germany
    J Neurooncol 81:53-60. 2007
    ..6 degrees C (42.4-49.5 degrees C) were measured and signs of local tumor control were observed. In conclusion, deep cranial thermotherapy using magnetic nanoparticles can be safely applied on glioblastoma multiforme patients...
  72. ncbi Enrichment of cell subpopulations applying automated MACS technique: purity, recovery and applicability for PCR-based chimerism analysis
    A Willasch
    Department of Pediatric Hematology, Oncology and Hemostaseology, Goethe University Frankfurt, Hospital for Children and Adolescents III, Frankfurt, Germany
    Bone Marrow Transplant 45:181-9. 2010
    ..Isolation of cell subpopulations by automated cell enrichment in post-transplant peripheral blood is feasible and fast providing excellent purity and recovery for routine lineage-specific chimerism analysis...
  73. ncbi The use of oligoperoxide-coated magnetic nanoparticles to label stem cells
    Daniela Sponarová
    Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq 2, 162 06 Prague 6, Czech Republic
    J Biomed Nanotechnol 7:384-94. 2011
    ..Such particles are thus promising for in vivo MR imaging of transplanted cells. Moreover, PVBM offers the possibility of additional modification by grafting compounds that reduce non-specific protein adsorption...
  74. ncbi Enhancement of magnetic nanoparticle-mediated gene transfer to astrocytes by 'magnetofection': effects of static and oscillating fields
    Mark Pickard
    Cellular and Neural Engineering Group, Institute for Science and Technology in Medicine, Keele University, Staffordshire, ST5 5BG, UK
    Nanomedicine (Lond) 5:217-32. 2010
    ..To assess the feasibility of using magnetic nanoparticles (MNPs) to transfect astrocytes derived for transplantation and determine if transfection efficacy can be enhanced by static and oscillating magnetic fields...
  75. ncbi GMR sensors: magnetoresistive behaviour optimization for biological detection by means of superparamagnetic nanoparticles
    A Manteca
    CEIT, Paseo de Manuel Lardizábal, N 15, 20018 Donostia San Sebastian, Spain
    Biosens Bioelectron 26:3705-9. 2011
    ..2 μm diameter magnetic carriers (7.68 pg ferrite/particle) have shown the best response and they have induced a shift in the magnetoresistive hysteresis loops up to 9% at 175 Oe...
  76. pmc Drug/dye-loaded, multifunctional iron oxide nanoparticles for combined targeted cancer therapy and dual optical/magnetic resonance imaging
    Santimukul Santra
    NanoScience Technology Center, Chemistry Department Burnett School of Biomedical Sciences, College of Medicine University of Central Florida, 12424 Research Parkway, Suite 400, Orlando, FL 32826, USA
    Small 5:1862-8. 2009
    ..The resulting folate-derivatized theranostics nanoparticles could allow for targeted optical/magnetic resonance imaging and targeted killing of folate-expressing cancer cells...
  77. ncbi Self-assembly of magnetic nanoparticles in evaporating solution
    Jiyeon Ku
    Department of Chemistry, University of California, Berkeley, California 94720, United States
    J Am Chem Soc 133:838-48. 2011
    ..Their effective interactions drive the formation of layered loop structures similar to those observed in experiments...
  78. ncbi Biological effects of 6 mT static magnetic fields: a comparative study in different cell types
    Bernadette Tenuzzo
    Department of Biological and Environmental Science and Technology, University of Lecce, Lecce, Italy
    Bioelectromagnetics 27:560-77. 2006
    ..From these data we conclude that 6 mT static MF exposure interfered with apoptosis in a cell type- and exposure time-dependent manner, while the effects of static MF exposure on the apoptotic program were independent of the drugs used...
  79. ncbi Core-shell NaYF4:Yb3+,Tm3+@FexOy nanocrystals for dual-modality T2-enhanced magnetic resonance and NIR-to-NIR upconversion luminescent imaging of small-animal lymphatic node
    Ao Xia
    Advanced Materials Laboratory and Department of Chemistry, Fudan University, Shanghai, PR China
    Biomaterials 32:7200-8. 2011
    ..Moreover, the toxicity of NaYF(4):Yb(3+),Tm(3+)@Fe(x)O(y) nanocrystals has also been evaluated by MTT assay, IC50 values, and histological analysis of lymphatic node sections...
  80. ncbi Magnetic nanoparticle-induced hyperthermia treatment under magnetic resonance imaging
    Alsayed A M Elsherbini
    National Institute of Laser Enhanced Science NILES, Cairo University, Cairo, Egypt
    Magn Reson Imaging 29:272-80. 2011
    ..Also, the results revealed that the tumor size in the all mice exposed to MRH is still as the same as before the treatment, but the rate of tumor growth was very slow by comparing with the growth rate of the control group...
  81. ncbi Efficient labeling of mesenchymal stem cells using cell permeable magnetic nanoparticles
    Jin Sook Suh
    Department of Craniomaxillofacial Reconstructive Sciences, School of Dentistry, Seoul National University, Seoul, Republic of Korea
    Biochem Biophys Res Commun 379:669-75. 2009
    ..Taken together, cell permeable magnetic nanoparticles conjugated with LMWP can be suggested as labeling tools for efficient magnetic imaging of transplanted cells...
  82. ncbi Bioprinted nanoparticles for tissue engineering applications
    Kivilcim Buyukhatipoglu
    Mechanical Engineering and Mechanics Department, Drexel University, Philadelphia, PA, USA
    Tissue Eng Part C Methods 16:631-42. 2010
    ..The hybrid nanobioprinting method can noninvasively manipulate and track bioactive factors and cells within tissue engineering structures...
  83. ncbi Tensile strain and magnetic particle force application do not induce MAP3K8 and IL-1B differential gene expression in a similar manner to fluid shear stress in human mesenchymal stem cells
    John R Glossop
    Institute for Science and Technology in Medicine, The Guy Hilton Research Centre, University of Keele, Stoke on Trent, Staffordshire, UK
    J Tissue Eng Regen Med 4:577-9. 2010
    ..This illustrates divergence in the process of mechanotransduction in mechanically stimulated MSCs...
  84. ncbi Mechanical integrin stress and magnetic forces induce biological responses in mesenchymal stem cells which depend on environmental factors
    Annika Kasten
    Medical Faculty, Laboratory of Cell Biology, University of Rostock, Rostock, Germany
    J Cell Biochem 111:1586-97. 2010
    ..However, the responses of cells depend strongly on the substrate to which they adhere and on the cross-talk between integrin-mediated signals and soluble factors...
  85. pmc GMR biosensor arrays: a system perspective
    D A Hall
    Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
    Biosens Bioelectron 25:2051-7. 2010
    ..Lastly, the multiplexing capability and reproducibility of the system was demonstrated by simultaneously monitoring sensors functionalized with three unique proteins at different concentrations in real-time...
  86. ncbi Preparation and characterization of monodisperse core-shell Fe3O4@SiO2 microspheres and its application for magnetic separation of nucleic acids from E. coli BL21
    Chao Ma
    State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Nanjing 210096, PR China
    J Biomed Nanotechnol 8:1000-5. 2012
    ..coli BL21) and verified the great application prospects for bioseparation technology of the biomoleculars...
  87. ncbi Stabilization and functionalization of iron oxide nanoparticles for biomedical applications
    Esther Amstad
    Laboratory for Surface Science and Technology, ETH Zurich, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    Nanoscale 3:2819-43. 2011
    ..A critical evaluation of different strategies to stabilize and functionalize core-shell superparamagnetic iron oxide NPs as well as a brief introduction to characterization methods to compare those strategies is given...
  88. ncbi Intracellular magneto-spatial organization of magnetic organelles inside intact bacterial cells
    Mohit Naresh
    Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, New Delhi 110016, India
    J Biomed Nanotechnol 7:572-7. 2011
    ..Our work opens promising avenues in the direction of measuring the magnetic behavior of nano-magnets inside living systems by utilizing an operationally straight-forward approach...
  89. ncbi Optimization of multiply acquired magnetic flux density B(z) using ICNE-Multiecho train in MREIT
    Hyun Soo Nam
    Department of Mathematics, Konkuk University, Seoul, Korea
    Phys Med Biol 55:2743-59. 2010
    ....
  90. ncbi Rapid isolation and detection of cancer cells by utilizing integrated microfluidic systems
    Kang Yi Lien
    Institute of Nanotechnology and Microsystems Engineering, National Cheng Kung University, Tainan, 701, Taiwan
    Lab Chip 10:2875-86. 2010
    ..Consequently, the proposed 3D microfluidic system incorporated with immunomagnetic beads may provide a promising automated platform for the rapid isolation and detection of cancer cells with a high sensitivity...
  91. ncbi Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins
    Jwa Min Nam
    Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60201, USA
    Science 301:1884-6. 2003
    ..Comparable clinically accepted conventional assays for detecting the same target have sensitivity limits of approximately 3 picomdar, six orders of magnitude less sensitive than what is observed with this method...
  92. ncbi MRI evaluation of the antitumor activity of paramagnetic liposomes loaded with prednisolone phosphate
    Evelina Cittadino
    Department of Chemistry, IFM and Molecular and Preclinical Imaging Centres, University of Torino, Via Nizza 52, I 10126, Torino, Italy
    Eur J Pharm Sci 45:436-41. 2012
    ..The accumulation of the amphipatic MRI label caused the occurrence of a long-term residual T(1) contrast still detectable 1week after injection...
  93. pmc Animal cryptochromes mediate magnetoreception by an unconventional photochemical mechanism
    Robert J Gegear
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 463:804-7. 2010
    ..This work emphasizes the utility of Drosophila transgenesis for elucidating the precise mechanisms of Cry-mediated magnetosensitivity in insects and also in vertebrates such as migrating birds...
  94. ncbi Potential biomarkers for esophageal carcinoma detected by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Li Hua Liu
    Research Center, Fourth Hospital of Hebei Medical University and Hebei Cancer Institute, Shijiazhuang, PR China
    Clin Chem Lab Med 48:855-61. 2010
    ....
  95. pmc Human cryptochrome exhibits light-dependent magnetosensitivity
    Lauren E Foley
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Commun 2:356. 2011
    ..The results show that human CRY2 has the molecular capability to function as a light-sensitive magnetosensor and reopen an area of sensory biology that is ready for further exploration in humans...
  96. ncbi The application of Fe3O4 nanoparticles in cancer research: a new strategy to inhibit drug resistance
    Xuemei Wang
    State Key Lab of Bioelectronics, Chien Shiung WU Laboratory, Southeast University, Nanjing 210096, People s Republic of China
    J Biomed Mater Res A 80:852-60. 2007
    ....
  97. ncbi Remote magnetic catheter navigation for cavotricuspid isthmus ablation in patients with common-type atrial flutter
    Dirk Vollmann
    Division of Cardiology and Pneumology, Heart Center, University of Gottingen, Gottingen, Germany
    Circ Arrhythm Electrophysiol 2:603-10. 2009
    ..Remote magnetic catheter navigation (RMN) may provide benefits for different ablation procedures, but its efficacy for CTI ablation has not been evaluated in a randomized, controlled trial...
  98. ncbi Navigational abilities of adult and experienced homing pigeons deprived of olfactory or trigeminally mediated magnetic information
    Anna Gagliardo
    Dipartimento di Biologia, University of Pisa, Italy
    J Exp Biol 212:3119-24. 2009
    ..Our data show that even in trained adult pigeons, olfactory cues are needed for homing from unfamiliar locations and that the lack of magnetic information does not affect navigational abilities of experienced adult homing pigeons...
  99. ncbi A polymer lab-on-a-chip for magnetic immunoassay with on-chip sampling and detection capabilities
    Jaephil Do
    Microsystems and BioMEMS Laboratory, Center for BioMEMS and Nanobiosciences, Department of Electrical and Computer Engineering and Computer Science, University of Cincinnati, Cincinnati, OH 45221, USA
    Lab Chip 8:542-9. 2008
    ..A sampling and detection of as low as 16.4 ng mL(-1) of mouse IgG has been successfully performed in 35 min for the entire procedure...
  100. pmc Multiplex protein assays based on real-time magnetic nanotag sensing
    Sebastian J Osterfeld
    Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:20637-40. 2008
    ..The multianalyte ability, sensitivity, scalability, and ease of use of the MNT-based protein assay technology make it a strong contender for versatile and portable molecular diagnostics in both research and clinical settings...
  101. ncbi Impact of remote magnetic catheter navigation on ablation fluoroscopy and procedure time
    Albert M Kim
    University of California, San Francisco, California, USA
    Pacing Clin Electrophysiol 31:1399-404. 2008
    ..Remote magnetic catheter navigation (RCN) is gaining acceptance in clinical cardiac electrophysiology, but details regarding how RCN affects procedure execution are not well characterized...

Research Grants59

  1. Design Optimization of Combined Magnetoencephalography and Susceptometry
    Solomon Gilbert Diamond; Fiscal Year: 2013
    ..Since the proposed system uses ultra-low field magnetics it may also be used to study neurovascular function in epilepsy for patients with implanted electrode arrays and ..
  2. Magnetoresistive Sensor Platform for Parallel Cancer Marker Detection
    Marc D Porter; Fiscal Year: 2013
    ..The goal is to construct and test this technology, which is based on the magnetics concepts that read the hard disk drive in most of today's laptop computers and portable music media players,..
  3. Triple Analysis of Blood Clotting using Driven and Diffusing Microbeads
    Richard Chasen Spero; Fiscal Year: 2013
    ..This Phase 1 SBIR comprises two specific aims: assembling an imaging/magnetics platform to perform the tests, and validating the tests against standard coagulometers...
  4. Cancer Sample Preparation with Micromachined Magnetic Sifter and Nanoparticles
    Shan X Wang; Fiscal Year: 2012
    ..We have formed an interdisciplinary team with expertise from magnetics, nanotechnology, cancer clinical practice and research, biochemistry, and proteomics to work on a novel ..
  5. TAS::75 0849::TAS
    KAI MING LO; Fiscal Year: 2011
    ..It is believed that the magnetics design technology (magnets, gradient, sweep and modulation coil) as well as our user interface and control ..
  6. PRE-MRI PATIENT SCREENING FOR INTRAOCULAR FOREIGN BODIES
    PETER CZIPOTT; Fiscal Year: 2000
    ..To develop this potential, Quantum Magnetics has formed a partnership with Dr. R...
  7. MAGNETIC RESONANCE IMAGING USING SQUIDS
    Sankaran Kumar; Fiscal Year: 1993
    ..Recent experiments at the University of California, Berkeley, and here at Quantum Magnetics have shown that SQUIDs can be used to detect radiofrequency nuclear magnetic signals...
  8. SUPERCONDUCTING MAGNET FOR MICROCOIL NMR
    YUKIKAZU IWASA; Fiscal Year: 2001
    ..from the Applicant's Abstract): The specific aims of this Phase I STTR project, proposed by the American Magnetics, Inc...
  9. A Low Cost Clinically Relevant 7T MRI Magnet
    Piotr Starewicz; Fiscal Year: 2007
    ..Stern Magnetics, LLC has successfully demonstrated the high performance of internally reinforced super- conducting wire with ..
  10. Novel Platform for Advanced MR Imaging of Animal
    Piotr Starewicz; Fiscal Year: 2005
    ..The ultimate goal of this process will also help to establish Stern Magnetics LLC as a competitive US manufacturer of high-field MRI magnet systems.
  11. Toxin Detection w/Antibody Fragments & Novel Biosensors
    Edward Elson; Fiscal Year: 2003
    ..We will also compare each system to standard ELISA. ..
  12. Biosensor for Contaminant-Free Platelets
    Edward Elson; Fiscal Year: 2002
    ..abstract_text> ..
  13. MR Method for Determining Magnetic Field Correlation
    Jens Jensen; Fiscal Year: 2005
    ..The means and standard deviations of the MFC values will be calculated for the subject pool. This will provide baseline data for the application of MFC imaging to neurological disorders. ..
  14. Paramagnetic Enhancement in Off-Resonance Rotating Frame
    Huiming Zhang; Fiscal Year: 2004
    ..We will generalize a method for assessing the quantity and environment of a paramagnetic probe required in specific application such as imaging drug delivery, cell migration and tumor growth. ..
  15. The Cardiac Atlas Project: Establishment of a Cardiac MRI Database.
    ALISTAIR ANDREW YOUNG; Fiscal Year: 2010
    ..By pooling data from many studies into a single resource, researchers will be able to perform standardized comparisons across many patient groups, in order to better predict and evaluate the effects of disease and treatment. ..
  16. HEPATIC TISSUE ENGINEERING
    Martin Yarmush; Fiscal Year: 2006
    ..The proposed studies will also provide basic tools useful in the development of other engineered tissues and organs. ..
  17. Motor-Functional Neuroanatomy in Cerebral Palsy
    George Wittenberg; Fiscal Year: 2006
    ..Because the TMS measurements are non-invasive, painless, and relatively rapid, this method has promise for motor general application in understanding, classifying, and treating patients with cerebral palsy. [unreadable] [unreadable]..
  18. MRS Measurements of GABA in Temporal Lobe Epilepsy
    Hoby Hetherington; Fiscal Year: 2007
    ..Therefore the development of robust methods for measuring GABA from the temporal lobe in patients with temporal lobe epilepsy would be of significant benefit. [unreadable] [unreadable] [unreadable]..
  19. Cellular MRI in Glioma and Radiation Necrosis
    Ali Syed Arbab; Fiscal Year: 2010
    ..Early detection of recurrent or metastatic glioma as well as early differentiation of glioma from radiation necrosis will help clinician to tackle the devastating neurological disease. ..
  20. Polynuclear Clusters in Nitrogenase-Structure Reactivity
    Dimitri Coucouvanis; Fiscal Year: 2007
    ..abstract_text> ..
  21. New MRI Sequences/RF Coils for Hand Psoriatic Arthritis
    WINGCHI KWOK; Fiscal Year: 2005
    ..This technology will allow us to start the clinical evaluation of the disease mechanism and the long-term effect of early treatment. ..
  22. Real Time Functional Genomics of Metabolism/Cell Arrays
    Martin Yarmush; Fiscal Year: 2004
    ..In summary, the proposed work seeks to provide fundamental research and a base of personnel equipped to solve problems in fields such as metabolic engineering where complex biological phenomena are under investigation. ..
  23. Polynuclear Clusters in Biology - Structure, Reactivity
    Dimitri Coucouvanis; Fiscal Year: 2005
    ..The function of the catecholate ligands in these compounds, as storage sites of oxidizing equivalents, will be determined. ..
  24. The Influence of Static Magnetic Fields on Brain tissue
    Andrzej Wieraszko; Fiscal Year: 2003
    ..The cell excitability, synaptic efficiency and action potentials recorded from the slices exposed to SMF will be studied. The directions of alternative and future research are delineated. ..
  25. Flourescent Ceramic Nanoprobes (RMI)
    TIMOTHY BOYLE; Fiscal Year: 2008
    ..All of the innovations uncovered during the preparation of these nanoprobes will be shared in order to benefit medical research applications beyond those proposed in this investigation. ..
  26. Differentiation of Glioma from Radiation Injury Using Cellular MRI
    Syed Ali; Fiscal Year: 2008
    ..This magnetic labeling technique will also help investigators to track the injected CTL in the body as well as in the targeted areas by magnetic resonance imaging (MRI). [unreadable] [unreadable] [unreadable]..
  27. Fast, Quantitative, Perfusion-Based functional-MRI
    Luis Hernandez Garcia; Fiscal Year: 2007
    ..These developments will be quite instrumental to the use of ASL perfusion imaging as a powerful tool for the study of brain function. ..
  28. Training in Stem Cell Research
    Martin Yarmush; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  29. ESCHERICHIA COLI INVASION OF BRAIN ENDOTHELIAL CELLS
    Sheng He Huang; Fiscal Year: 2007
    ..To further characterize the role of IbeABP in E. coil K1 invasion of human BMEC. (3). To determine how E. coil K1 invasion gene expression is regulated by the IbeR and environmental signals (glucose and oxygen tension). ..
  30. Living Cell Arrays for Real Time Functional Genomics
    Martin Yarmush; Fiscal Year: 2009
    ..Dr. Jeffrey Morgan (Brown Univ., Providence, RI), a molecular biologist and expert in gene therapy, will lead the Molecular Biology and Cell Analysis group focusing on reporter cell line development. ..
  31. Electroporation and transcutaneous extraction of drugs
    SATHYANARAYANA MURTHY; Fiscal Year: 2006
    ..Further we also plan to correlate the time course of unbound ciprofloxacin in dermal ECF with that in synovial fluid determined by microdialysis in rat. [unreadable] [unreadable] [unreadable]..
  32. Motor Map Plasticity in Constraint Therapy for Stroke
    George Wittenberg; Fiscal Year: 2005
    ..This could lead to the development of new rehabilitative strategies based on the interaction between therapeutic interventions and the physiology and anatomy of recovery. ..
  33. Tumor-reactive IgG in the diagnosis of ovarian cancer
    Douglas Taylor; Fiscal Year: 2005
    ..Ultimately, antigenic proteins, linked with histologic type and stage of disease, will be combined into the development of protein arrays to screen for circulating reactive IgG as an early diagnostic test. ..
  34. NUMERICAL SIMULATION OF CARDIAC ELECTROPHYSIOLOGY
    Bradley Roth; Fiscal Year: 2005
    ..Each hypothesis is motivated by experimental data, and the goal of the theoretical simulations is to interpret these data. ..
  35. Intermolecular Multiple-Quantum Coherence Effects in NMR
    Warren Warren; Fiscal Year: 2002
    ....
  36. Nuclease-Resistant Aptamers to Botox and Anthrax Toxins
    John Bruno; Fiscal Year: 2004
    ..Such reagents could also be used in environmental biosensors or diagnostic test kits for detection of BOTOX and anthrax toxins in body fluids or environmental samples. ..
  37. MRI Method for In Vivo Iron Quantification
    Jens Jensen; Fiscal Year: 2007
    ..We will also compare the MRI data to iron measurements obtained with SQUID biosusceptometry. ..
  38. Characterization of Tear Dynamics
    Jianhua Wang; Fiscal Year: 2007
    ..g. dry eye). [unreadable] [unreadable]..
  39. Data-driven Real-Time Surgical Simulation from Reality-based Soft-tissue Models
    JAYDEV DESAI; Fiscal Year: 2009
    ..Widespread availability of this state of the art training tool will help to elevate and equalize the level of basic surgical skills of residents in training by transcending national and resource barriers. ..
  40. Structural Mapping of Protein Complexes by Hydrogen/Deuterium Exchange
    Alan Marshall; Fiscal Year: 2009
    ..This project is multidisiplinary and pulls together several distinguished collaborators with focused research projects that will benefit directly from H/D exchange with high-resolution mass analysis. ..
  41. Matrix metalloproteinases as biomarkers of neurodegeneration
    Veronica Shubayev; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  42. MOLECULAR BASIS OF HEPATIC HYPERMETABOLISM IN BURNS
    Martin Yarmush; Fiscal Year: 2001
    ..abstract_text> ..
  43. Prenatal NSAID Use and Miscarriage
    De Kun Li; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  44. Mitral Annular Remodeling for MR Therapy
    Kiyotaka Fukamachi; Fiscal Year: 2005
    ..Therefore, this proposed research program is an important first step in this novel procedure's development as one potential therapeutic option for high-risk CHF patients with functional MR. ..
  45. International Conference on Biological Inorganic Chemistry
    Dimitri Coucouvanis; Fiscal Year: 2005
    ..A major use of the support sought in this application will assist mainly the junior participants of the meeting and particularly women and minorities among them. ..
  46. SOURCES OF SOUND IN SPEECH
    ANDERS LOFQVIST; Fiscal Year: 2005
    ..Such data are not only necessary for the development of computational models of the vocal tract, but will also serve as references for comparison with the speech of disordered populations. ..
  47. Craniosacral Therapy in Migraine Feasibility Study
    John Mann; Fiscal Year: 2007
    ..Duration of the study for each subject is 16 weeks. Length of the entire project is 2 years. [unreadable] [unreadable] [unreadable]..
  48. NANOSCALE IRON PHASES IN NEURODEGENERATIVE DISEASES
    Jon Dobson; Fiscal Year: 2005
    ..The Pl's combination of skills and experience related to the research proposed here is unique and unavailable in the US. ..
  49. 7 Tesla Whole-body MRI scanner
    Peter van Zijl; Fiscal Year: 2005
    ..This 7T whole-body upgrade is essential for continued high-quality state-of-the-art research at our institutions and for the national facilities provided by our Research Resource. ..
  50. Miniature Low-Noise High-Quality MRI Preamplifiers
    Hiroyuki Fujita; Fiscal Year: 2007
    ..The long-term goal is to become a main supplier of new high-quality low-noise miniature preamplifiers for the MRI hardware industry. [unreadable] [unreadable] [unreadable]..
  51. FUNCTIONAL MRI MAPPING OF HUMAN THALAMOCORTICAL NETWORKS
    Wei Chen; Fiscal Year: 2003
    ..This is vital to the understanding of human brain functions involving both sensory perception and higher cognitive processes at physiological and pathological conditions. ..
  52. Multi-Tx MRI for Uniform B1 Excitation at High Bo Field
    Scott King; Fiscal Year: 2004
    ..At the end of this four year project, we will have demonstrated a possible solution to the inhomogenous transmit problem at 3T, which will be transferable to higher fields with the appropriate array coil designs. ..
  53. INDUCED ABORTION AND BREAST CANCER RISK
    De Kun Li; Fiscal Year: 2001
    ....
  54. MAGNETOELASTIC SENSORS FOR BIOMEDICAL MONITORING
    KEAT ONG; Fiscal Year: 2003
    ..The wireless, remote query nature of the sensor technology would also find great utility for in-situ monitoring of biological chemical analyte concentrations such as glucose. ..
  55. Novel Anti-Malarials by Combinatorial Pharmacogenomics
    Joseph DeRisi; Fiscal Year: 2006
    ..The compiled relationships from known anti-malarials, novel quinolines, and toxicology will then be used to guide and optimize additional synthesis efforts toward the ultimate goal of producing effective therapeutics. ..
  56. Prenatal MF Exposure & Miscarriage Risk Among Women
    De Kun Li; Fiscal Year: 2009
    ..The findings from the proposed study will provide much needed confirmation of the recently reported results and advance our understanding of a MF health effect. ..
  57. Exposure to Bisphenol A & Reproductive Effect in Humans
    De Kun Li; Fiscal Year: 2007
    ..The proposed study will evaluate the reproductive effects of BPA in settings where there have been high levels of exposure. The study will also investigate effects in multiple human generations. ..
  58. NEW CONTRAST AGENTS FOR MR IMAGING OF THE IMMUME SYSTEM
    Thomas Meade; Fiscal Year: 2003
    ..A MR contrast agent that is uniquely sensitive to this enzyme process would be of great utility in dissecting this mechanism. ..
  59. An In-Situ Biliary Manometer for Sphincter of Oddi Dysfunction Diagnosis
    KEAT ONG; Fiscal Year: 2008
    ..As an example, with proper modifications the same sensor technology can be applied for measuring the pressure within an artery stent for in-stent stenosis detection. [unreadable] [unreadable] [unreadable]..