lubrication

Summary

Summary: The application of a substance to diminish friction between two surfaces. It may refer to oils, greases, and similar substances for the lubrication of medical equipment but it can be used for the application of substances to tissue to reduce friction, such as lotions for skin and vaginal lubricants.

Top Publications

  1. ncbi Compliant layer acetabular cups: friction testing of a range of materials and designs for a new generation of prosthesis that mimics the natural joint
    S C Scholes
    Centre for Biomedical Engineering, School of Engineering, Durham University, UK
    Proc Inst Mech Eng H 220:583-96. 2006
  2. ncbi Effect of swing phase load on metal-on-metal hip lubrication, friction and wear
    Sophie Williams
    School of Mechanical Engineering, Institute of Medical and Biological Engineering, University of Leeds, Leeds, LS2 9JT, UK
    J Biomech 39:2274-81. 2006
  3. ncbi Relative safety of sexual lubricants for rectal intercourse
    Kristin M Sudol
    Population Council, New York, New York, USA
    Sex Transm Dis 31:346-9. 2004
  4. ncbi Preferences and practices related to vaginal lubrication: implications for microbicide acceptability and clinical testing
    Sarah Braunstein
    Population Council, New York, New York 10017, USA
    J Womens Health (Larchmt) 14:424-33. 2005
  5. ncbi Recommendations for the management of postmenopausal vaginal atrophy
    D W Sturdee
    Department of Obstetrics and Gynaecology, Heart of England NHS Foundation Trust, Solihull Hospital, UK
    Climacteric 13:509-22. 2010
  6. ncbi Lubrication at physiological pressures by polyzwitterionic brushes
    Meng Chen
    Physical and Theoretical Chemistry Laboratory, University of Oxford, Oxford OX1 3QZ, UK
    Science 323:1698-701. 2009
  7. pmc The slippery slope: lubricant use and rectal sexually transmitted infections: a newly identified risk
    Pamina M Gorbach
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA 90095 1772, USA
    Sex Transm Dis 39:59-64. 2012
  8. pmc Identification of personal lubricants that can cause rectal epithelial cell damage and enhance HIV type 1 replication in vitro
    Othell Begay
    Population Council, New York, New York 10065, USA
    AIDS Res Hum Retroviruses 27:1019-24. 2011
  9. pmc Covert use, vaginal lubrication, and sexual pleasure: a qualitative study of urban U.S. Women in a vaginal microbicide clinical trial
    Susie Hoffman
    HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute and Columbia University, 1051 Riverside Drive, Unit 15, New York, NY 10032, USA
    Arch Sex Behav 39:748-60. 2010
  10. ncbi Replens versus dienoestrol cream in the symptomatic treatment of vaginal atrophy in postmenopausal women
    M Bygdeman
    Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden
    Maturitas 23:259-63. 1996

Detail Information

Publications267 found, 100 shown here

  1. ncbi Compliant layer acetabular cups: friction testing of a range of materials and designs for a new generation of prosthesis that mimics the natural joint
    S C Scholes
    Centre for Biomedical Engineering, School of Engineering, Durham University, UK
    Proc Inst Mech Eng H 220:583-96. 2006
    ..To determine accurately the mode of lubrication under which these joints operate, a synthetic lubricant was used in all these tests...
  2. ncbi Effect of swing phase load on metal-on-metal hip lubrication, friction and wear
    Sophie Williams
    School of Mechanical Engineering, Institute of Medical and Biological Engineering, University of Leeds, Leeds, LS2 9JT, UK
    J Biomech 39:2274-81. 2006
    ..during surgery may alter loading of THRs during the swing phase of gait leading to changes in fluid film lubrication, friction and wear...
  3. ncbi Relative safety of sexual lubricants for rectal intercourse
    Kristin M Sudol
    Population Council, New York, New York, USA
    Sex Transm Dis 31:346-9. 2004
    ..The current study was conducted to determine the relative safety of sexual lubricants for rectal use...
  4. ncbi Preferences and practices related to vaginal lubrication: implications for microbicide acceptability and clinical testing
    Sarah Braunstein
    Population Council, New York, New York 10017, USA
    J Womens Health (Larchmt) 14:424-33. 2005
    ..Preferences and practices regarding lubrication during sex, therefore, likely influence microbicide acceptability and use...
  5. ncbi Recommendations for the management of postmenopausal vaginal atrophy
    D W Sturdee
    Department of Obstetrics and Gynaecology, Heart of England NHS Foundation Trust, Solihull Hospital, UK
    Climacteric 13:509-22. 2010
    ....
  6. ncbi Lubrication at physiological pressures by polyzwitterionic brushes
    Meng Chen
    Physical and Theoretical Chemistry Laboratory, University of Oxford, Oxford OX1 3QZ, UK
    Science 323:1698-701. 2009
    ..0004 at pressures as high as 7.5 megapascals. This extreme lubrication is attributed primarily to the strong hydration of the phosphorylcholine-like monomers that make up the ..
  7. pmc The slippery slope: lubricant use and rectal sexually transmitted infections: a newly identified risk
    Pamina M Gorbach
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA 90095 1772, USA
    Sex Transm Dis 39:59-64. 2012
    ..Use of lubricant products is extremely common during receptive anal intercourse (RAI) yet has not been assessed as a risk for acquisition of sexually transmitted infections (STIs)...
  8. pmc Identification of personal lubricants that can cause rectal epithelial cell damage and enhance HIV type 1 replication in vitro
    Othell Begay
    Population Council, New York, New York 10065, USA
    AIDS Res Hum Retroviruses 27:1019-24. 2011
    ..In addition, the epithelial damage caused by these and many other lubricants may have implications for enhancing HIV transmission in vivo. These data emphasize the importance of performing more rigorous safety testing on these products...
  9. pmc Covert use, vaginal lubrication, and sexual pleasure: a qualitative study of urban U.S. Women in a vaginal microbicide clinical trial
    Susie Hoffman
    HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute and Columbia University, 1051 Riverside Drive, Unit 15, New York, NY 10032, USA
    Arch Sex Behav 39:748-60. 2010
    ..trial of tenofovir gel, a candidate microbicide, we explored the intersection of sexual pleasure and vaginal lubrication to understand whether and under what circumstances women would use a microbicide gel covertly with primary ..
  10. ncbi Replens versus dienoestrol cream in the symptomatic treatment of vaginal atrophy in postmenopausal women
    M Bygdeman
    Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden
    Maturitas 23:259-63. 1996
    ..This study was designed to evaluate the efficacy of Replens, a non-hormonal moisturizing vaginal gel, on symptoms of vaginal atrophy in postmenopausal women, in comparison with Dienoestrol (Cilag), an oestrogenic vaginal cream...
  11. ncbi Boundary lubrication by lubricin is mediated by O-linked beta(1-3)Gal-GalNAc oligosaccharides
    G D Jay
    Department of Medicine, Section of Emergency Medicine, Brown University School of Medicine, Providence, RI 02903, USA
    Glycoconj J 18:807-15. 2001
    b>Lubrication of mammalian joints is mediated by lubricin, a product of megakaryocyte stimulating factor gene (MSF; GenBank accession #U70136) expression...
  12. ncbi Treatment of Sjögren's syndrome-associated dry eye an evidence-based review
    Esen Karamursel Akpek
    The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ophthalmology 118:1242-52. 2011
    ..Outcomes-based review of reported treatment options for patients with dry eye secondary to Sjögren's syndrome (SS)...
  13. ncbi Comparison of friction and lubrication of different hip prostheses
    S C Scholes
    Centre for Biomedical Engineering, University of Durham, UK
    Proc Inst Mech Eng H 214:49-57. 2000
    ..Various workers have assessed the lubrication modes of different joints by measuring the friction at the bearing surfaces, using different lubricants...
  14. ncbi Polyelectrolyte brushes: a novel stable lubrication system in aqueous conditions
    Motoyasu Kobayashi
    JST ERATO Takahara Soft Interfaces Project, CE80, Kyushu University, 744 Motooka, Nishi ku, Fukuoka, Japan
    Faraday Discuss 156:403-12; discussion 413-34. 2012
    ..of the brush was prevented owing to the good affinity of the poly(SPMK) brush for water forming a water lubrication layer, and electrostatic repulsive interactions among the brushes bearing sulfonic acid groups...
  15. ncbi Alkalinization of intra-cuff lidocaine and use of gel lubrication protect against tracheal tube-induced emergence phenomena
    J P Estebe
    Service d Anesthésie Réanimation Chirurgicale 2, Universite de Rennes 1, Rennes, France
    Br J Anaesth 92:361-6. 2004
    We sought to determine the benefits of using alkalinized lidocaine 40 mg to fill the cuff of a tracheal tube (ETT) in combination with water-soluble gel lubrication to prevent post-intubation sore throat.
  16. ncbi Mucosal irritation potential of personal lubricants relates to product osmolality as detected by the slug mucosal irritation assay
    Els Adriaens
    Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium
    Sex Transm Dis 35:512-6. 2008
    ..In the current study, it was determined whether musosal irritation potency of personal lubricants is related to varying product osmolalities...
  17. pmc Cartilage shear dynamics during tibio-femoral articulation: effect of acute joint injury and tribosupplementation on synovial fluid lubrication
    B L Wong
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Osteoarthritis Cartilage 18:464-71. 2010
    ..To determine the effects of acute injury and tribosupplementation by hyaluronan (HA) on synovial fluid (SF) modulation of cartilage shear during tibio-femoral articulation...
  18. ncbi Prediction of lubricating film thickness in UHMWPE hip joint replacements
    D Jalali-Vahid
    Department of Mechanical and Medical Engineering, University of Bradford, DB7 1DP, Bradford, UK
    J Biomech 34:261-6. 2001
    An elastohydrodynamic lubrication model developed for a ball-in-socket configuration in a previous studies by the present authors (Jalali-Vahid et al...
  19. ncbi The effects of proteins on the friction and lubrication of artificial joints
    S C Scholes
    School of Engineering, Durham University, Durham, UK
    Proc Inst Mech Eng H 220:687-93. 2006
    ..joints of different material combinations were tested in a friction simulator to determine their friction and lubrication properties...
  20. ncbi Normal and prosthetic synovial joints are lubricated by surface-active phospholipid: a hypothesis
    B A Hills
    Mater Children s Hospital and Department of Medicine university of Queensland, Queensland University ot Technology, Brisbane, Australia
    J Arthroplasty 18:499-505. 2003
    ..This, in turn, leads to the replenishment of SAPL, as tested in OA, and the concept of prelubricating prostheses before implantation...
  21. ncbi Boundary lubrication under water
    Wuge H Briscoe
    Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QZ, UK
    Nature 444:191-4. 2006
    Boundary lubrication, in which the rubbing surfaces are coated with molecular monolayers, has been studied extensively for over half a century...
  22. ncbi Synovial fluid lubrication of artificial joints: protein film formation and composition
    Jingyun Fan
    Tribology Group, Department of Mechanical Engineering, Imperial College London
    Faraday Discuss 156:69-85; discussion 87-103. 2012
    ..Clearly it is important to understand the fundamental lubrication mechanisms which control the wear process...
  23. ncbi Laboratory studies on the tribology of hard bearing hip prostheses: ceramic on ceramic and metal on metal
    K Vassiliou
    Centre for Biomedical Engineering, School of Engineering, University of Durham, Durham, UK
    Proc Inst Mech Eng H 221:11-20. 2007
    ..The tribological performance of these joints is superior to that of conventional metal- or ceramic-on-polymer designs...
  24. ncbi Porcine gastric mucin (PGM) at the water/poly(dimethylsiloxane) (PDMS) interface: influence of pH and ionic strength on its conformation, adsorption, and aqueous lubrication properties
    Seunghwan Lee
    Laboratory for Surface Science and Technology, Department of Materials, Swiss Federal Institute of Technology ETH Hönggerberg, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    Langmuir 21:8344-53. 2005
    ..The lubrication mechanism of the self-mated sliding contact of PDMS by means of surface modification with PGM is discussed in ..
  25. ncbi Polymer-brush lubrication in the limit of strong compression
    L Spirin
    Institute of Physics, Johannes Gutenberg University, Staudingerweg 7, 55099, Mainz, Germany
    Eur Phys J E Soft Matter 33:307-11. 2010
    ..In agreement with our theory, the simulation reveals simple power laws, R ∼ W (0.53), η ∼ W (-0.46), and F ∼ W (0.54), for the non-Newtonian regime...
  26. ncbi CID of singly charged antioxidants applied in lubricants by means of a 3D ion trap and a linear ion trap-Orbitrap mass spectrometer
    Alexander Kassler
    Research Division Instrumental Analytical Chemistry, Institute of Chemical Technologies and Analytics, Vienna University of Technology, Austria
    J Mass Spectrom 46:517-28. 2011
    ..For characterizing degradation products of antioxidants, the LIT-Orbitrap hybrid system, allowing the determination of accurate m/z values for product ions, is the method of choice...
  27. ncbi Determination of lubricating film thickness for permeable hydrogel and non-permeable polyurethane layers bonded to a rigid substrate with particular reference to cushion form hip joint replacements
    G McClure
    Department of Mechanical Engineering, University of Leeds
    Proc Inst Mech Eng H 210:89-93. 1996
    ..Comparison of the experimental results and the theoretical predictions based upon elastohydrodynamic lubrication analysis showed good agreement in the entraining experiments where the film thickness was greater than 150 nm...
  28. ncbi Structural determination of zinc dithiophosphates in lubricating oils by gas chromatography-mass spectrometry with electron impact and electron-capture negative ion chemical ionization
    M Becchi
    Service Central d Analyse, CNRS, Vernaison, France
    J Chromatogr A 905:207-22. 2001
    ..The diastereoisomer mixtures of 2-hydroxy-sec.-alkyl radicals were completely separated on GC analysis...
  29. pmc Adaptive mechanically controlled lubrication mechanism found in articular joints
    George W Greene
    Materials Department, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 108:5255-9. 2011
    ..Although many different lubrication mechanisms have been proposed, it is becoming increasingly apparent that the tribological performance of ..
  30. ncbi Lubrication of metal-on-metal hip joints: the effect of protein content and load on film formation and wear
    C Myant
    Tribology Group, Department of Mechanical Engineering, Imperial College London, United Kingdom
    J Mech Behav Biomed Mater 6:30-40. 2012
    ..Thus film formation in MoM hip joints is very susceptible to high contact pressures which might be due to implant misalignment and edge-loading...
  31. ncbi Surface-active phospholipid: a Pandora's box of clinical applications. Part II. Barrier and lubricating properties
    B A Hills
    Mater Children s Hospital and Department of Medicine, University of Queensland, Australia
    Intern Med J 32:242-51. 2002
    ..Highly desirable properties include boundary lubrication (lubricity), release (antistick) and the ability of the strongly adsorbed and strongly cohesive SAPL linings to ..
  32. ncbi Practical prevention of vaginal and rectal transmission of HIV by adapting the oral defense: use of commercial lubricants
    S Baron
    University of Texas Medical Branch, Department of Microbiology and Immunology, Galveston, Texas 77555, USA
    AIDS Res Hum Retroviruses 17:997-1002. 2001
    ..S. FDA category, and may be used by recipient women or men, they should be tested in clinical trials to help prevent sexual transmission of HIV...
  33. pmc Acceptability of microbicidal surrogates among Zambian women
    Deborah L Jones
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Sex Transm Dis 35:147-53. 2008
    ....
  34. ncbi Elastohydrodynamic lubrication analysis of metal-on-metal hip prostheses under steady state entraining motion
    M Jagatia
    Department of Mechanical and Medical Engineering, University of Bradford, UK
    Proc Inst Mech Eng H 215:531-41. 2001
    The elastohydrodynamic lubrication problem of metal-on-metal hip joint replacements was considered in this study. A simple ball-in-socket configuration was used to represent the hip prosthesis...
  35. ncbi Preventing sexual transmission of HIV: anti-HIV bioregulatory and homeostatic components of commercial sexual lubricants
    D Nguyen
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555 1070, USA
    J Biol Regul Homeost Agents 18:268-74. 2004
    ..Furthermore, clinical trials of these lubricants and components seem to be indicated because of their FDA safety level, wide availability, and low cost...
  36. ncbi Analysis of fluid film lubrication in artificial hip joint replacements with surfaces of high elastic modulus
    Z M Jin
    Department of Mechanical and Manufacturing Engineering, University of Bradford
    Proc Inst Mech Eng H 211:247-56. 1997
    b>Lubrication mechanisms and contact mechanics have been analysed for total hip joint replacements made from hard bearing surfaces such as metal-on-metal and ceramic-on-ceramic...
  37. ncbi High friction moments in large hard-on-hard hip replacement bearings in conditions of poor lubrication
    Nicholas E Bishop
    Biomechanics Section, TUHH Hamburg University of Technology, Denickestrasse 15, D 21073 Hamburg, Germany
    J Orthop Res 31:807-13. 2013
    ..clinical results for large diameter metal replacement bearings for the hip are related to compromised lubrication due to poor cup placement, which increases wear as well as friction moments...
  38. pmc Is wetter better? An evaluation of over-the-counter personal lubricants for safety and anti-HIV-1 activity
    Charlene S Dezzutti
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e48328. 2012
    ..The two iso-osmolar lubricants, Good Clean Love and PRÉ, and both silicone-based lubricants, Female Condom 2 lubricant and Wet Platinum, were the safest in our testing algorithm...
  39. ncbi Effect of protein lubrication on the wear properties of materials for prosthetic joints
    Y S Liao
    The J Vernon Luck Center for Orthopaedic Research, Los Angeles Orthopaedic Hospital, Los Angeles, California 90007 2697, USA
    J Biomed Mater Res 48:465-73. 1999
    ..The results indicated directions for further research to clarify the lubricating properties of serum, and for developing a universal standard test lubricant...
  40. ncbi Biphasic surface amorphous layer lubrication of articular cartilage
    Simon Graindorge
    Institute of Medical and Biological Engineering, University of Leeds, Leeds LS2 9JT, UK
    Med Eng Phys 27:836-44. 2005
    ..From the lubrication point of view however, a simple biphasic model is unable to account for the extremely low friction coefficients ..
  41. ncbi Intraoral lubrication of PRP-1, statherin and mucin as studied by AFM
    I Cecilia Hahn Berg
    YKI, Institute for Surface Chemistry, Box 5607, SE 114 86 Stockholm, Sweden
    Biofouling 20:65-70. 2004
    The aim of this paper was to elucidate the mechanisms behind salivary lubrication with special emphasis on the lubricity of three key components of the pellicle, viz human acidic proline-rich protein 1 (PRP-1), human statherin and bovine ..
  42. ncbi Liposomes act as effective biolubricants for friction reduction in human synovial joints
    Sarit Sivan
    Department of Biomedical Engineering, Technion Israel Institute of Technology, Haifa 32000, Israel
    Langmuir 26:1107-16. 2010
    ..to liquid-disordered phase transition temperature slightly below physiological temperature are optimal for lubrication. High phospholipid headgroup hydration, high compressibility, and softness are the common denominators of all ..
  43. ncbi In vitro friction and lubrication of large bearing hip prostheses
    S Flanagan
    Department of Materials, Science and Technology, University of Limerick, Limerick, Ireland
    Proc Inst Mech Eng H 224:853-64. 2010
    ..The study detailed here used a hip friction simulator to assess the friction and lubrication properties of large-diameter hip bearings of metal-on-metal and ceramic-on-reinforced-polymer couplings...
  44. ncbi Mechanical effects of the intraarticular administration of high molecular weight hyaluronic acid plus phospholipid on synovial joint lubrication and prevention of articular cartilage degeneration in experimental osteoarthritis
    Tsutomu Kawano
    Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Arthritis Rheum 48:1923-9. 2003
    To examine in vivo the effects of a mixture of high molecular weight hyaluronic acid (HA) plus phospholipids on joint lubrication and articular cartilage degeneration.
  45. ncbi Lubrication regimes in lumbar total disc arthroplasty
    A Shaheen
    Department of Mechanical Engineering, School of Engineering, The University of Birmingham, Edgbaston, Birmingham, UK
    Proc Inst Mech Eng H 221:621-7. 2007
    ..The aim of this paper was to investigate the lubrication regimes that occur in lumbar total disc arthroplasty devices...
  46. ncbi Does additional lubrication affect condom slippage and breakage?
    A M Smith
    Centre for Study of Sexually Transmissible Diseases, La Trobe University, Victoria, Australia
    Int J STD AIDS 9:330-5. 1998
    ....
  47. pmc Adsorption, lubrication, and wear of lubricin on model surfaces: polymer brush-like behavior of a glycoprotein
    Bruno Zappone
    Materials Department and Materials Research Laboratory, University of California Santa Barbara, Santa Barbara, California, USA
    Biophys J 92:1693-708. 2007
    ..These results support recent suggestions that boundary lubrication and wear protection in articular joints are due to the presence of a biological polyelectrolyte on the ..
  48. ncbi Constituents and pH changes in protein rich hyaluronan solution affect the biotribological properties of artificial articular joints
    T Kitano
    Orthopaedic Research Laboratory, Columbia University, New York, NY, USA
    J Biomech 34:1031-7. 2001
    ..pH and viscosity independence at low speed and promotes pH and viscosity dependence at high speed in the lubrication of UHMWPE against SUS...
  49. ncbi Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmission
    Edward J Fuchs
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 5554, USA
    J Infect Dis 195:703-10. 2007
    ..To inform the development of rectal microbicide formulation, we evaluated the effects of hyperosmolar gels on the rectal mucosa...
  50. doi Materials science. Sweet, hairy, soft, and slippery
    Seunghwan Lee
    Laboratory for Surface Science and Technology, Department of Materials, ETH Zurich, 8093 Zurich, Switzerland
    Science 319:575-6. 2008
  51. ncbi The effects of lubricant composition on in vitro wear testing of polymeric acetabular components
    A Wang
    Stryker Howmedica Osteonics, Inc, Mahwah, New Jersey 07430, USA
    J Biomed Mater Res B Appl Biomater 68:45-52. 2004
    ..It is recommended that lubricants for simulator testing be standardized to control total protein content as well as albumin/globulin ratio...
  52. pmc Frequent use of lubricants for anal sex among men who have sex with men: the HIV prevention potential of a microbicidal gel
    A Carballo-Dieguez
    HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute, NY, USA
    Am J Public Health 90:1117-21. 2000
    ..This study assessed frequency of rectal lubricant use, opinions about rectal microbicidal gels, and willingness to participate in acceptability trials of rectal microbicides among Latino men who have sex with men (MSM)...
  53. ncbi Ionic liquids in tribology
    Ichiro Minami
    Department of Chemical Engineering, Iwate University, 4 3 5 Ueda, Morioka, Iwate, 020 8551, Japan
    Molecules 14:2286-305. 2009
    ..from 1,3-dialkylimidazolium, with a higher alkyl group on the imidazolium cation being beneficial for good lubrication, while it reduces the thermo-oxidative stability...
  54. pmc Acceptability and use of sexual barrier products and lubricants among HIV-seropositive Zambian men
    D L Jones
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    AIDS Patient Care STDS 22:1015-20. 2008
    ....
  55. ncbi Acceptability of a carrageenan-based candidate vaginal microbicide and matching placebo: findings from a phase II safety trial among women in Chiang Rai, Thailand
    Heidi E Jones
    Population Council, New York, New York, USA
    J Womens Health (Larchmt) 18:1003-10. 2009
    ..To evaluate extended acceptability of vaginal use of a carrageenan-based candidate microbicide and placebo in northern Thai women...
  56. ncbi Conformational and adsorptive characteristics of albumin affect interfacial protein boundary lubrication: from experimental to molecular dynamics simulation approaches
    Hsu Wei Fang
    Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan
    Colloids Surf B Biointerfaces 68:171-7. 2009
    ..joint, it is believed the lubricants form protective layers on the sliding surfaces under the boundary lubrication mechanism...
  57. ncbi Acceptability of formulations and application methods for vaginal microbicides among drug-involved women: results of product trials in three cities
    T M Hammett
    Abt Associates Inc, Cambridge, Massachusetts 02138 1168, USA
    Sex Transm Dis 27:119-26. 2000
    ..Female-controlled methods of HIV prevention, such as vaginal microbicides, are urgently needed, particularly among drug-involved women. Acceptability research is critical to product development...
  58. ncbi Gel lubrication of the tracheal tube cuff reduces pulmonary aspiration
    M C Blunt
    Department of Anaesthesia, Queen Elizabeth Hospital, King Lynn, United Kingdom
    Anesthesiology 95:377-81. 2001
    ..Theoretically, lubrication of the cuff with a water-soluble gel might prevent aspiration by plugging the channels in the cuff wall...
  59. ncbi Ionic liquids as advanced lubricant fluids
    María Dolores Bermúdez
    Grupo de Ciencia de Materiales e Ingeniería Metalúrgica, Departamento de Ingenieria de Materiales y Fabricación, Universidad Politecnica de Cartagena, Campus Muralla del Mar 30202 Cartagena, Spain
    Molecules 14:2888-908. 2009
    ..Some emerging fields are those of lubrication, surface engineering and nanotechnology...
  60. ncbi Effects of handpiece lubrication on resin-based composite bond strength to enamel
    J S Knight
    Department of General Dentistry, USC College of Dental Medicine, Charleston 29425, USA
    Am J Dent 12:116-8. 1999
    To evaluate the effects of handpiece lubrication on the bond strengths of resin-based composite (RBC) to enamel using two different bonding systems.
  61. ncbi Mineral oil lubricants cause rapid deterioration of latex condoms
    B Voeller
    Mariposa Foundation, Topanga, CA 90290
    Contraception 39:95-102. 1989
    ..Aqueous nonoxynol-9 spermicide did not affect either burst index. The implications of these results for contraception and protection from sexually transmitted diseases, including AIDS, are discussed...
  62. pmc The effect of hyaluronidase, phospholipase, lipid solvent and trypsin on the lubrication of canine flexor digitorum profundus tendon
    Yulong Sun
    Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Orthop Res 26:1225-9. 2008
    Although the flexor digitorum profundus (FDP) tendon's gliding resistance is low, the lubrication mechanism that enables this is unclear...
  63. ncbi The effect of femoral head diameter upon lubrication and wear of metal-on-metal total hip replacements
    S L Smith
    School of Mechanical Engineering, University of Leeds, UK
    Proc Inst Mech Eng H 215:161-70. 2001
    ..The joints were subject to dynamic motion and loading cycles simulating walking for both lubrication and wear studies...
  64. ncbi Viscous boundary lubrication of hydrophobic surfaces by mucin
    Gleb E Yakubov
    Unilever Corporate Research, Colworth Science Park, Bedfordshire MK44 1LQ, UK
    Langmuir 25:2313-21. 2009
    ..It was found that mucin facilitates lubrication between hydrophobic PDMS surfaces, leading to a 10-fold reduction in boundary friction coefficient for rough ..
  65. ncbi Importance of head diameter, clearance, and cup wall thickness in elastohydrodynamic lubrication analysis of metal-on-metal hip resurfacing prostheses
    Feng Liu
    Institute of Medical and Biological Engineering, Department of Mechanical Engineering, University of Leeds, Leeds, UK
    Proc Inst Mech Eng H 220:695-704. 2006
    The main design features of metal-on-metal (MOM) hip resurfacing prostheses in promoting elastohydrodynamic lubrication were investigated in the present study, including the femoral head diameter, the clearance, and the cup wall ..
  66. ncbi Differential tissue-on-tissue lubrication by ophthalmic formulations
    Anne E Meyer
    Industry University Center for Biosurfaces, University at Buffalo, Buffalo, New York 14214 3007, USA
    J Biomed Mater Res B Appl Biomater 82:74-88. 2007
    ..of hydrophilic polymer-containing formulations between the "blinking" tissues would compare with lubrication by saline, alone, or an oil-emulsion preparation...
  67. pmc Experimental verification of the role of interstitial fluid pressurization in cartilage lubrication
    Ramaswamy Krishnan
    Department of Mechanical Engineering, Columbia University, 500 West 120th Street, 220 SW Mudd, MC 4703, New York, NY 10027, USA
    J Orthop Res 22:565-70. 2004
    ..Fitting the experimental data to a previously proposed biphasic boundary lubrication model for cartilage yielded an equilibrium friction coefficient of mu eq=0.284+/-0.044...
  68. ncbi Soft lubrication
    J M Skotheim
    Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge CB3 0WA, United Kingdom
    Phys Rev Lett 92:245509. 2004
    We consider some basic principles of fluid-induced lubrication at soft interfaces. In particular, we quantify how a soft substrate changes the geometry of and the forces between surfaces sliding past each other...
  69. pmc The diaphragm and lubricant gel for prevention of cervical sexually transmitted infections: results of a randomized controlled trial
    Gita Ramjee
    Medical Research Council, Durban, South Africa
    PLoS ONE 3:e3488. 2008
    ....
  70. ncbi Lubricating ability of aspirated synovial fluid from emergency department patients with knee joint synovitis
    Gregory D Jay
    Department of Medicine, Brown University School of Medicine, Rhode Island 02903, USA
    J Rheumatol 31:557-64. 2004
    ..Loss of synovial fluid's (SF) lubricating ability has been implicated in the pathogenesis of degenerative joint disease...
  71. ncbi The process of lubrication impairment and its involvement in temporomandibular joint disc displacement: a theoretical concept
    D W Nitzan
    The Hebrew University Hadassah School of Dental Medicine, Jerusalem, Israel
    J Oral Maxillofac Surg 59:36-45. 2001
    ..The joint lubrication system and the process of its breakdown are clarified and an attempt is made to evaluate the possible effect of ..
  72. ncbi Tracheal fluid leakage in benchtop trials: comparison of static versus dynamic ventilation model with and without lubrication
    Mital H Dave
    Department of Anaesthesia, University Children s Hospital, Steinwiesstrasse 75, 8032, Zurich, Switzerland
    J Anesth 24:247-52. 2010
    ..This study compared the potential of a static and dynamic ventilation benchtop model and cuff lubrication in testing the tracheal sealing properties of a given TT cuff.
  73. ncbi Lubrication of circumcision site for prevention of meatal stenosis in children younger than 2 years old
    Hassan Bazmamoun
    Department of Pediatrics, Division of Gastroenterology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
    Urol J 5:233-6. 2008
    ..We evaluated the topical use of a lubricant jelly after circumcision in boys in order to reduce the risk of meatal stenosis...
  74. ncbi Reduced expression and proteolytic susceptibility of lubricin/superficial zone protein may explain early elevation in the coefficient of friction in the joints of rats with antigen-induced arthritis
    Khaled A Elsaid
    Rhode Island Hospital, Providence, RI 02881, USA
    Arthritis Rheum 56:108-16. 2007
    ..To investigate the effect of arthritis development and progression on the integrity and function of lubricin and the relationship of lubricin to cartilage damage in a rat antigen-induced arthritis model...
  75. ncbi Thin film rheology and lubricity of hyaluronic acid solutions at a normal physiological concentration
    Rafael Tadmor
    Materials Research Laboratory, and Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    J Biomed Mater Res 61:514-23. 2002
    ..beam) interferometry to measure surface shapes and separations (to +/-1 A), the normal, viscous, and shear (lubrication) forces between smooth mica surfaces in aqueous hyaluronic acid (HA) solutions were measured...
  76. pmc Effects of sustained interstitial fluid pressurization under migrating contact area, and boundary lubrication by synovial fluid, on cartilage friction
    M Caligaris
    Department of Mechanical Engineering, Columbia University, New York, NY 10027, United States
    Osteoarthritis Cartilage 16:1220-7. 2008
    This experimental study tests two hypotheses which address outstanding questions in cartilage lubrication: can the friction coefficient remain low under sustained physiological loading conditions? How effective is synovial fluid (SF) in ..
  77. ncbi The lubricative function of artificial joint material surfaces by confocal laser scanning microscopy. Comparison with natural synovial joint surface
    Masanori Kobayashi
    Brigham and Women s Hospital, Harvard Medical School, USA
    Biomed Mater Eng 13:429-37. 2003
    ..under the physiological loading by confocal laser scanning microscopy (CLSM) to clarify the mechanism of lubrication in natural joints and subsequently improve the quality of artificial joints...
  78. ncbi Effect of synovial fluid on boundary lubrication of articular cartilage
    T A Schmidt
    Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California San Diego, La Jolla, CA 92093, USA
    Osteoarthritis Cartilage 15:35-47. 2007
    The lubrication of articulating cartilage surfaces in joints occurs through several distinct modes...
  79. ncbi The role of the surface amorphous layer of articular cartilage in joint lubrication
    S Graindorge
    Institute of Medical and Biological Engineering, University of Leeds, UK
    Proc Inst Mech Eng H 220:597-607. 2006
    ..particular, the amorphous layer that covers the surface of articular cartilage is thought to play some role in lubrication. This study aimed to characterize the surface amorphous layer (SAL) using a variety of techniques, including ..
  80. ncbi Comparison of the efficacy between lidocaine spray plus lidocaine jelly lubrication and lidocaine jelly lubrication alone prior to nasogastric intubation: a prospective double-blind randomized controlled study
    Supot Pongprasobchai
    Department of Medicine, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand
    J Med Assoc Thai 90:41-7. 2007
    ..The authors conducted a double-blind randomized controlled study to compare a commercial-available 10% lidocaine spray plus 2% lidocaine jelly lubrication and 2% lidocaine jelly lubrication alone prior to NG intubation.
  81. ncbi Boundary lubrication in vivo
    B A Hills
    Department of Medicine, University of Queensland and Mater Children s Hospital, Brisbane, Australia
    Proc Inst Mech Eng H 214:83-94. 2000
    Evidence is reviewed for the concept that the body employs essentially the same lubrication system in many sites in the body where tissues slide over each other with such ease...
  82. ncbi Tribological principles in metal-on-metal hip joint design
    D Dowson
    School of Mechanical Engineering, University of Leeds, Leeds, UK
    Proc Inst Mech Eng H 220:161-71. 2006
    ..Powerful indications have emerged of the dominant role of mixed lubrication in current metal-on-metal hip replacements, with elastohydrodynamic film thickness controlling wear...
  83. ncbi Understanding the role of corrosion in the degradation of metal-on-metal implants
    Y Yan
    School of Mechanical Engineering, University of Leeds, Leeds, UK
    Proc Inst Mech Eng H 220:173-81. 2006
    ..The specific action of proteins in corrosion and tribocorrosion for high-carbon Co-Cr-Mo and low-carbon Co-Cr-Mo alloys is discussed...
  84. ncbi The effect of microstructure on the wear of cobalt-based alloys used in metal-on-metal hip implants
    R Varano
    Department of Mining, Metals and Materials, McGill University, Montreal, Quebec, Canada
    Proc Inst Mech Eng H 220:145-59. 2006
    ..on the wear of cobalt-based alloys used in metal-on-metal hip implants was investigated in a boundary lubrication regime designed to represent the conditions that occurred some of the time in vivo...
  85. ncbi 'Severe' wear challenge to 'as-cast' and 'double heat-treated' large-diameter metal-on-metal hip bearings
    J G Bowsher
    Department of Engineering and IRC in Biomedical Materials, Queen Mary, University of London, London, UK
    Proc Inst Mech Eng H 220:135-43. 2006
    ..This is in sharp contrast with the published significance of bearing diameter and radial clearance on the wear of MOM hip bearings...
  86. ncbi Metal-on-metal bearings surfaces: materials, manufacture, design, optimization, and alternatives
    G H Isaac
    DePuy International Ltd, Leeds, UK
    Proc Inst Mech Eng H 220:119-33. 2006
    ....
  87. ncbi Metal-on-metal hip joint tribology
    D Dowson
    School of Mechanical Engineering, The University of Leeds, Leeds, UK
    Proc Inst Mech Eng H 220:107-18. 2006
    ..Metal-on-polymer hip replacements operate in the boundary lubrication regime, thus leading to the design guidance to reduce the femoral head diameter as much as is feasible to ..
  88. ncbi Effect of wear of bearing surfaces on elastohydrodynamic lubrication of metal-on-metal hip implants
    F Liu
    School of Mechanical Engineering, University of Leeds, Leeds, UK
    Proc Inst Mech Eng H 219:319-28. 2005
    The effect of geometry change of the bearing surfaces owing to wear on the elastohydrodynamic lubrication (EHL) of metal-on-metal (MOM) hip bearings has been investigated theoretically in the present study...
  89. ncbi Increased total knee arthroplasty ultra-high molecular weight polyethylene wear using a clinically relevant hyaluronic acid simulator lubricant
    J Desjardins
    Department of Bioengineering, Clemson University, SC 29634, USA
    Proc Inst Mech Eng H 220:609-23. 2006
    ..These findings support the hypothesis that the addition of HA to simulator lubricant is capable of producing CoCr femoral component surface damage similar to that observed in vivo...
  90. ncbi Transient elastohydrodynamic lubrication analysis of metal-on-metal hip implant under simulated walking conditions
    F Liu
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, LS2 9JT, UK
    J Biomech 39:905-14. 2006
    The transient elastohydrodynamic lubrication (EHL) analysis was performed in this study for a typical metal-on-metal bearing employing a polyethylene backing underneath a metallic cup inlay under dynamic operating conditions of load and ..
  91. ncbi [Viscosity determination of synovial fluids from the canine hip and elbow joint as well as the human knee joint]
    Gabriele Helms
    Klinik für Kleintiere der Stiftung Tierärztliche Hochschule Hannover, Hannover
    Berl Munch Tierarztl Wochenschr 121:374-80. 2008
    ..of pathological changes in both human and canine hip joints is mainly caused by a lack of synovial fluid lubrication. This results in an increased joint abrasion...
  92. ncbi The influence of clearance on friction, lubrication and squeaking in large diameter metal-on-metal hip replacements
    Claire L Brockett
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK
    J Mater Sci Mater Med 19:1575-9. 2008
    ..investigated in this study using a hip friction simulator to examine the influence of clearance on friction, lubrication and squeaking...
  93. ncbi The tribology of metal-on-metal total hip replacements
    S C Scholes
    Centre for Biomedical Engineering, School of Engineering, Durham University, Durham, UK
    Proc Inst Mech Eng H 220:183-94. 2006
    ..These types of joint offer a potential solution to enhance the longevity of prosthetic hip systems; however, problems may arise owing to the effects of metal ion release, which are, as yet, not fully understood...
  94. ncbi [FE-analysis of surface stresses for the tribological system in total hip prostheses]
    Bernd Arno Behrens
    Institut für Umformtechnik und Umformmaschinen IFUM, Leibniz Universitat Hannover, Produktionstechnisches Zentrum Hannover PZH, Garbsen, Deutschland
    Biomed Tech (Berl) 51:367-70. 2006
    ..In the future adapted prostheses have to be developed that ensure optimal friction and absorption characteristics of the components...
  95. ncbi Prediction of lubrication regimes in two-piece metacarpophalangeal prostheses
    Thomas J Joyce
    Centre for Rehabilitation and Engineering Studies, School of Mechanical and Systems Engineering, Stephenson Building, University of Newcastle upon Tyne, Claremont Road, Newcastle upon Tyne, NE1 7RU, UK
    Med Eng Phys 29:87-92. 2007
    ..These were compared by calculating the lubrication regime for the material combinations and operating conditions expected at the metacarpophalangeal joints of the ..
  96. ncbi Static coefficient of friction between stainless steel and PMMA used in cemented hip and knee implants
    N Nuño
    Département de Génie de la Production Automatisée, Ecole de technologie superieure, Universite du Quebec, 1100 Notre Dame Str W, Montreal, Quebec, Canada, H3C 1K3
    Clin Biomech (Bristol, Avon) 21:956-62. 2006
    ..The measurement of this coefficient using a repeatable and reproducible methodology for materials used in total hip arthroplasty is missing from the literature...
  97. ncbi Tribological behaviour of orthodontic archwires under dry and wet sliding conditions in-vitro. I--Frictional behaviour
    Abdenacer Berradja
    Departments of Metallurgy and Materials Engineering, Katholieke Universiteit Leuven, Leuven, Belgium
    Aust Orthod J 22:11-9. 2006
    ..To evaluate the frictional behaviour of orthodontic archwires in dry and wet conditions in-vitro...
  98. ncbi Metal-on-metal hip simulator study of increased wear particle surface area due to 'severe' patient activity
    J G Bowsher
    Department of Engineering and IRC in Biomedical Materials, Queen Mary, University of London, London, UK
    Proc Inst Mech Eng H 220:279-87. 2006
    ..that 'severe'-gait conditions will change wear, wear particle sizes, and morphology owing to a decline in joint lubrication. Four carbon MOM hip bearings 40 mm high were subjected to normal-walking and fast-jogging simulations in an ..
  99. ncbi The effect of 'running-in' on the tribology and surface morphology of metal-on-metal Birmingham hip resurfacing device in simulator studies
    K Vassiliou
    Centre for Biomedical Engineering, Durham University, Durham, UK
    Proc Inst Mech Eng H 220:269-77. 2006
    ..24 mm3 per 10(6) cycles over the final 2 x 10(6) cycles of testing. The friction tests suggested boundary lubrication initially, but at 1 x 10(6) cycles a mixed lubrication regime was evident...
  100. ncbi Development rationale for an articular surface replacement: a science-based evolution
    G H Isaac
    DePuy International Limited, Leeds, UK
    Proc Inst Mech Eng H 220:253-68. 2006
    ....
  101. ncbi History and modern concepts in surface replacement
    D McMinn
    The Birmingham Nuffield Hospital and Royal Orthopaedic Hospital, The McMinn Centre, 25 Highfield Road, Edgbaston, Birmingham B15 3DP, UK
    Proc Inst Mech Eng H 220:239-51. 2006
    ..Modern hip resurfacing using metal-on-metal bearings has shown good medium-term results in the most challenging subgroup--young active patients...

Research Grants63

  1. Oral Mucins as a Diagnostic Indicator and Therapeutic Treatment for Xerostomia
    DAVID JOHN CULP; Fiscal Year: 2011
    ..Mucins perform many protective functions, including hydration and lubrication of tissue surfaces as well as interaction with pathogens, either alone or as part of large complexes with other ..
  2. Evaluation of an MRI Biomarker for Meniscal Repair
    Hollis G Potter; Fiscal Year: 2010
    ..the contact area between the incongruent articular surfaces of the distal femoral and proximal tibial, joint lubrication, chondrocyte nutrition and joint stability [1]...
  3. Lubricin Function in Articulating Joints
    Matthew L Warman; Fiscal Year: 2012
    ..We will study mice that express different forms of lubricin and also study biologic samples from patients with normal and damaged joints to begin correlating lubricin variation with human joint health. ..
  4. Sex, sex steroids and dry eye syndromes
    David A Sullivan; Fiscal Year: 2013
    ..effects on the meibomian gland;and (3) explore the role of sex and sex steroids in the control of boundary lubrication and surfactant proteins at the ocular surface and/or adnexa...
  5. A Web Based Self Management Intervention for Intermittent Urinary Catheter Use
    Mary H Wilde; Fiscal Year: 2013
    ..perform CIC in a variety of situations with good technique;(5) choose optimal catheter, equipment, and lubrication;and (6) adapt to social needs...
  6. Joint Capsule Biomechanics and Transport in Rat Models of Aging and Disease
    WILLIAM JOSEPH MCCARTY; Fiscal Year: 2012
    ..diseases, such as osteoarthritis (OA), result in pathological changes to the synovial fluid in joints, reducing lubrication function and leading to degenerative wear and often to pain and disability...
  7. Ca2+ and secretory dynamics in salivary acinar cells
    David I Yule; Fiscal Year: 2013
    ..It is essential for the hydration of the oral mucosa;it provides lubrication, begins nutrient digestion and imparts antimicrobial and mechanical protection for the mouth and upper ..
  8. Silicone-free glass pre-filled syringe system for Biological Drugs.
    VINAY G SAKHRANI; Fiscal Year: 2013
    ..TriboFilm Research, Inc. proposes the development of their TriboGlide(R) silicone-free lubrication system for use in glass prefilled syringes...
  9. Aging Osteoarthritis Effect on Structure-Function of Human Meniscal Attachments
    ADAM CHRISTOPHER ABRAHAM; Fiscal Year: 2013
    Project Summary/Abstract: Menisci are fibrocartilagenous structures that aid in load distribution and joint lubrication. Their functionality relies in part on the uniquely graded interfaces that join the menisci to the underlying bone...
  10. Swarming as a model for surface-sensing in Salmonella typhimurium
    Rasika M Harshey; Fiscal Year: 2012
    ..and excrete surfactants and polysaccharides that aid surface motility by generating wetness and providing lubrication. Our studies in this grant period have established that external wetness is more critical for swarming in S...
  11. A new multiphase polymeric material for cushion-bearing orthopedic implants
    BRUCE LAWRENCE CARVALHO; Fiscal Year: 2013
    ..Also, they are associated with very low friction since they can deform microscopically to induce fluid film lubrication associated with synovial fluid...
  12. In situ imaging of OA cartilage micro-fluidics
    Christopher Price; Fiscal Year: 2013
    ..e. load support and lubrication), which are dependent on the biphasic behaviors of the tissue, are progressively compromised...
  13. Regulation of lacrimal gland development and regeneration
    Helen P Makarenkova; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Dry eye syndrome is a chronic lack of sufficient lubrication in the eye due to malfunction or damage to the lacrimal gland...
  14. Engineering Lubrication in Tissue Engineered Cartilage
    AKEPATI HARI REDDI; Fiscal Year: 2013
    ..A key component of articular cartilage lubrication is superficial zone protein (SZP), which displays altered levels in animal models of early- and late-stage OA...
  15. Targeted microcarrier design and optimization
    David M Eckmann; Fiscal Year: 2013
    ..mediating NC motion in vascular targeted drug delivery involving three distinct scales: a macroscopic regime, a lubrication regime and an adhesion regime...
  16. Biophysical Modeling of Fluid and Solute Transport in the TMJ Disc
    Hai Yao; Fiscal Year: 2010
    ..on the tissue mechanical function and establish fluid flow dependent mechanisms for disc loading support and lubrication. To accomplish Specific Aim 1, we will: a) determine hydraulic permeability, fixed charge density, and ..
  17. A novel therapeutic for the treatment of persistent corneal epithelial defects
    Bennie H Jeng; Fiscal Year: 2010
    ..In general, traditional therapy of PED consists of aggressive lubrication with preservative-free artificial tears and ointments, the use of bandage soft contact lenses, pressure ..
  18. Mechanisms of Articular Cartilage Lubrication
    Robert L Sah; Fiscal Year: 2010
    ..an apposing tissue surface with remarkable tribological propertieslow friction, low wear, and multiple modes of lubrication acting to lower friction and/or wear...
  19. Patterned Microtexture for Improved Durability of Orthopedic Knee Implants
    RONALD L JACOBSEN; Fiscal Year: 2013
    ..will add to the implant's femoral component a surface texture that is designed to create hydrodynamic lubrication at low sliding velocities...
  20. BIOTRIBOLOGY OF DIARTHRODIAL JOINTS
    Gerard A Ateshian; Fiscal Year: 2013
    ..years much progress has been made in our understanding of the basic engineering science of articular cartilage lubrication, driven significantly by the progress achieved in the prior funding periods (1995- 2008) of this grant...
  21. Engineering Tendon Grafts for Better Outcomes
    Chunfeng Zhao; Fiscal Year: 2013
    ..Our preliminary studies in vitro have shown that cd-HA-lubricin further improves the lubrication of extrasynovial tendon to a level comparable to intrasynovial tendon...
  22. Health Empowerment for MSM in South Africa
    Tim Lane; Fiscal Year: 2013
    ..3) greater increases in sexual health-promoting behaviors, including consistent condom and water-based lubrication use with male partners, regular HIV testing among HIV-negative MSM every 6 months, and regular monitoring of ..
  23. Modeling shoe-floor interface properties to predict slips and falls
    Mark S Redfern; Fiscal Year: 2012
    ..micro-level properties of the shoe-floor-contaminant interface (material and surface characteristics along with lubrication properties), and 2) macro- level designs of the shoe (i.e. tread and shape) and floor...
  24. Restitution of Lubrication in ACL Deficient Joints Preventing Wear
    Gregory Jay; Fiscal Year: 2009
    ..Lubricin and superficial zone protein (SZP) are the boundary lubricants of articular cartilage- a lubrication mechanism which arises in the absence of viscosity...
  25. Silicone-free glass pre-filled syringe system for Biological Drugs.
    VINAY SAKHRANI; Fiscal Year: 2009
    ..We propose the development of glass prefilled syringes with the TriboGlide(r) silicone-free lubrication system based on perfluoropolyether chemistry...
  26. FEMALE SEXUAL AROUSAL: CLITORAL AND VAGINAL PHYSIOLOGY
    Abdulmaged Traish; Fiscal Year: 2003
    ..afflicted women are utilizing "off-label" oral vasoactive agents for treatment of diminished genital swelling/lubrication responses in the absence of such physiologic and clinical trial data, suggesting demand for improved female ..
  27. THE ROLE OF RETINOIDS IN LACRIMAL GLAND FUNCTION
    John Ubels; Fiscal Year: 2002
    ..The lacrimal gland fluid provides the ocular surface with lubrication, anti-bacterial proteins, electrolytes and nutrients...
  28. PROLINE-RICH GLYCOPROTEIN MASTICATORY LUBRICATION
    Lawrence Tabak; Fiscal Year: 1991
    The purpose of this investigation is to examine the structural basis of proline-rich glycoprotein mediated lubrication. The salivary secretions which bathe the oral cavity play a significant role in maintaining the health of the hard and ..
  29. MECHANISMS OF IMMUNOTOXICITY OF ORGANOPHOSPHATES
    Stephen Pruett; Fiscal Year: 1990
    ....
  30. Novel therapy for female sexual dysfunction
    Garry Southan; Fiscal Year: 2001
    ..no attention directed at elucidating the fundamental mechanisms accounting for clitoral engorgement, vaginal lubrication, and alterations in vaginal and vulval mucosal blood flows accompanying sexual arousal...
  31. REGULATION OF GLANDULAR MUCOUS CELL SECRETION
    DAVID CULP; Fiscal Year: 2001
    ..e., increased dental caries and lack of lubrication)...
  32. Ginkgo Biloba: Antidepressant-Induced Sexual Dysfunction
    Cindy Meston; Fiscal Year: 2003
    ..In women, the side effects most commonly reported include decreased sexual arousal with decreased lubrication, delayed or inhibited orgasm, and decreased sexual desire...
  33. Alcohol drinking in affiliative rodents
    Andrey Ryabinin; Fiscal Year: 2009
    ....
  34. DEVELOPMENT OF CELL LINES FROM SUBLINGUAL GLANDS
    DAVID CULP; Fiscal Year: 1992
    ..Protective functions which have been attributed to mucins, include: 1) lubrication and hydration of oral surfaces; 2) selection for the adherence as well as clearance of specific micro-organisms;..
  35. [Ca2+]i and Secretory Dynamics in Parotid Acinar Cells
    David Yule; Fiscal Year: 2007
    Saliva is vital for oral health. It is essential for the hydration of the oral mucosa; it provides lubrication, begins nutrient digestion and imparts antimicrobial and mechanical protection for the mouth and upper gastrointestinal tract...
  36. Low Temp Decontamination/Sterilize/Dental Handpieces
    Mohamed Labib; Fiscal Year: 2005
    ..caused by the combined effects of poor cleaning of internal channels and surfaces, improper or inadequate lubrication of moving parts, and repeated steam sterilization...
  37. SILICONE-FREE LOW FRICTION COATING FOR SYRINGES
    PAUL VERNON; Fiscal Year: 2000
    ..1 billion in the US alone. An acceptable alternative to silicone oil will produce an initial demand of 100 million coated stoppers a year. ..
  38. Vaginal Gel to Enhance Lubrication & Sperm Function
    JOANNA ELLINGTON; Fiscal Year: 2003
    ..aims to validate proof of concept for a vaginal gel, "Pro~Cept, designed to provide sperm-safe personal lubrication and an optimal environment for post-ejaculatory sperm function, to promote cervical mucus penetration...
  39. BIOTRIBOLOGY OF DIARTHRODIAL JOINTS
    Gerard Ateshian; Fiscal Year: 1999
    DESCRIPTION (Adapted from the Applicant's Abstract): Understanding the lubrication of diarthrodial joints has been an important objective in the field of biomechanics since the early part of this century...
  40. SILICONE-FREE LOW FRICTION COATING FOR SYRINGES
    VINAY SAKHRANI; Fiscal Year: 2006
    ..abstract_text> ..
  41. GUINEA PIG SUBLINGUAL GLAND AS A MUCOUS CELL MODEL
    DAVID CULP; Fiscal Year: 1991
    ..Protective functions which have been attributed to mucins include: 1) lubrication and hydration of oral surfaces; 2) selection for the adherence as well as clearance of -specific micro-..
  42. CONFORMATION OF DENTAL SALIVARY MOLECULES
    Robert Baier; Fiscal Year: 1993
    ..The biological functions of PRG include masticatory lubrication, bacterial binding, pellicle formation and calcium coordination...
  43. AGE, PSYCHOSEXUAL RESPONSE, AND REPRODUCTIVE HORMONES
    Patricia Morokoff; Fiscal Year: 1990
    ..It is hypothesized that estrogen will play a more significant role in determining amount of vaginal lubrication (important in preventing painful intercouse) than in determining amount of vaginal vascongestion, a measure ..
  44. PLEURAL LIQUID EXCHANGE AND LUNG MECHANICS
    STEPHEN LAI FOOK; Fiscal Year: 2007
    ..The primary function of pleural liquid is lubrication of the pleural surfaces during breathing...
  45. ENHANCEMENT OF LUBRICATION FOR ARTIFICIAL CARTILAGE
    Martine LaBerge; Fiscal Year: 1992
    ..It is postulated that this surgical technique could be improved through providing an intrinsic boundary lubrication mechanism attached to the surface of the artificial material...
  46. Thymosin beta 4 and Autoimmune Ocular Surface Disease
    Gabriel Sosne; Fiscal Year: 2004
    ..pathology of dry eye disease has improved significantly during recent years, the mainstay of treatment, ocular lubrication, provides only palliative relief at best to patients with severe dry eye disease...
  47. NANOCOMPOSITE SURFACE FOR VERY LOW WEAR ORTHOPEDICS
    Eric Tobin; Fiscal Year: 1999
    ..the metallic surfaces in this configuration is still of concern, particularly due to the questionable amount of lubrication available to the artificial joint...
  48. PSYCHOPHYSICS OF ASTRINGENT MATERIALS
    HARRY LAWLESS; Fiscal Year: 2000
    ..Astringency involves de-lubrication of the salivary coating in the oral cavity A critical step in the development of astringency is the association ..
  49. PREVENTIVE ONCOLOGY ACADEMIC AWARD
    David Garabrant; Fiscal Year: 1991
    ..The applicant will develop an exposure classification system, systematically evaluate cancer risks for each exposure, and use empirical Bayes techniques to rank the associations to identify those that are more likely to be true...
  50. GRC on Musculoskeletal Biology & Bioengineering
    Robert Sah; Fiscal Year: 2004
    ..multiple tissues include biomaterial fabrication, cell sources, integration at tissue/material interfaces, lubrication at surfaces, skeletal development, growth and regeneration, insights from total joint replacement, the in vivo ..
  51. DEVELOPMENT OF A BIOPOLYMER BASED TEAR FILM SUPPLEMENT
    Edward Ellis; Fiscal Year: 1999
    ..viscoelastic properties of the mucin component of the tear film to supplement the structure, stability and lubrication of the tear film...
  52. Cartilage Integration: in Vitro to In Vivo Translation
    Robert Sah; Fiscal Year: 2006
    ..that tailoring cartilaginous implants and host tissues to enhance site- specific integration or, alternatively, lubrication can create key localized features that facilitate successful treatment of cartilage defects...
  53. NEW LUBRICANTS FOR ROTATING ANODE X-RAY TUBE BEARINGS
    WARD HALVERSON; Fiscal Year: 2000
    ..The coating's composition can be far from phase-equilibrium, thus providing unique lubrication properties...
  54. Novel therapy for female sexual dysfunction
    Garry Southan; Fiscal Year: 2004
    ..no attention directed at elucidating the fundamental mechanisms accounting for clitoral engorgement, vaginal lubrication, and alterations in vaginal and vulval mucosal blood flows accompanying sexual arousal...
  55. CARCINOGENESIS--HIGHLY REACTIVE NITROSAMINES
    RICHARD LOEPPKY; Fiscal Year: 2001
    ....
  56. Biophysics of Microbicides for STD Prevention
    David Katz; Fiscal Year: 2005
    ..It will also provide unprecedented biophysical data relevant to mechanisms of STD infection in women. ..
  57. CONFORMATION OF DENTALLY RELEVANT SALIVARY MOLECULES
    RONALD LOOMIS; Fiscal Year: 1992
    ..biologically relevant functions to this project are bacterial clearance from the oral cavity and masticatory lubrication. The empirically-based methods to be used for structural analyses are nuclear magnetic resonance (NMR), ..
  58. DEVELOPMENT OF A BIOPOLYMER-BASED TEAR FILM SUPPLEMENT
    Edward Ellis; Fiscal Year: 2002
    ..produce a tear supplement of natural, purified mucin, and establish its effects on the structure, stability and lubrication of the tear film, using the clinical model accepted by the FDA...
  59. Causal and Nonlinear Models of Cancer Risk Among Autoworkers
    Ellen Eisen; Fiscal Year: 2009
    ..In 2004, the National Toxicology Program (NIEHS) announced plans for long-term animal testing of MWF to help address lingering uncertainty regarding the carcinogenic risk posed by ongoing exposures. ..
  60. Molecular Regulation of Lacrimal Gland Branching
    Richard Lang; Fiscal Year: 2005
    ..Regardless of the etiology, in severe cases the absence of lubrication to the cornea can result in ulceration and blindness...
  61. NEW LUBRICANTS FOR ROTATING ANODE X-RAY TUBE BEARINGS
    MICHAEL DRORY; Fiscal Year: 2003
    ..Good Phase H results should lead to immediate application in commercial rotating anode X-ray tubes. PROPOSED COMMERCIAL APPLICATION: Not available. ..
  62. Mesothelial Lubrication and Pleural Homeostatsis
    Stephen Loring; Fiscal Year: 2008
    ..We propose to study the hydrodynamic mechanisms important for lubrication of mesothelial surfaces...
  63. Pulsus Paradoxus Monitor
    Gregory Jay; Fiscal Year: 2005
    ..Future Phase 2 activities could include prospective PP threshold testing in the emergency department and home monitoring of selected asthmatic patients, both of which would impact efficient clinical resource utilization. ..