electric impedance

Summary

Summary: The resistance to the flow of either alternating or direct electrical current.

Top Publications

  1. ncbi Bioelectrical impedance analysis--part I: review of principles and methods
    Ursula G Kyle
    Geneva University Hospital, Switzerland
    Clin Nutr 23:1226-43. 2004
  2. pmc An appraisal of the electrical resistance method for assessing root surface area
    Yang Cao
    School of Forest Sciences, University of Eastern Finland, PO Box 111, FI 80101 Joensuu, Finland
    J Exp Bot 61:2491-7. 2010
  3. ncbi Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology
    Máiria A Deli
    Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research Centre of the Hungarian Academy of Sciences, Temesvari korut 62, H 6726 Szeged, Hungary
    Cell Mol Neurobiol 25:59-127. 2005
  4. ncbi Bioelectrical impedance analysis-part II: utilization in clinical practice
    Ursula G Kyle
    Clinical Nutrition Unit, Geneva University Hospital, 1211 Geneva 14, Switzerland
    Clin Nutr 23:1430-53. 2004
  5. pmc Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers
    Luying Peng
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Nutr 139:1619-25. 2009
  6. pmc Accuracy of body mass index in diagnosing obesity in the adult general population
    A Romero-Corral
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, MN 55905, USA
    Int J Obes (Lond) 32:959-66. 2008
  7. pmc Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier
    Michael J Bernas
    Department of Surgery, University of Arizona, Tucson, Arizona, USA
    Nat Protoc 5:1265-72. 2010
  8. ncbi Development of bioelectrical impedance analysis prediction equations for body composition with the use of a multicomponent model for use in epidemiologic surveys
    Shumei S Sun
    Lifespan Research Center, Department of Community Health, Wright State University School of Medicine, Dayton, OH 45420, USA
    Am J Clin Nutr 77:331-40. 2003
  9. ncbi Magnetic resonance electrical impedance tomography (MREIT) for high-resolution conductivity imaging
    Eung Je Woo
    Department of Biomedical Engineering, Kyung Hee University, Korea
    Physiol Meas 29:R1-26. 2008
  10. ncbi Optimization of multiply acquired magnetic flux density B(z) using ICNE-Multiecho train in MREIT
    Hyun Soo Nam
    Department of Mathematics, Konkuk University, Seoul, Korea
    Phys Med Biol 55:2743-59. 2010

Detail Information

Publications418 found, 100 shown here

  1. ncbi Bioelectrical impedance analysis--part I: review of principles and methods
    Ursula G Kyle
    Geneva University Hospital, Switzerland
    Clin Nutr 23:1226-43. 2004
    ..ESPEN guidelines for the clinical use of BIA measurements are described in a paper to appear soon in Clinical Nutrition...
  2. pmc An appraisal of the electrical resistance method for assessing root surface area
    Yang Cao
    School of Forest Sciences, University of Eastern Finland, PO Box 111, FI 80101 Joensuu, Finland
    J Exp Bot 61:2491-7. 2010
    ..Electrical analogues for roots and stem comprising resistors are discussed in relation to in situ measurements...
  3. ncbi Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology
    Máiria A Deli
    Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research Centre of the Hungarian Academy of Sciences, Temesvari korut 62, H 6726 Szeged, Hungary
    Cell Mol Neurobiol 25:59-127. 2005
    ....
  4. ncbi Bioelectrical impedance analysis-part II: utilization in clinical practice
    Ursula G Kyle
    Clinical Nutrition Unit, Geneva University Hospital, 1211 Geneva 14, Switzerland
    Clin Nutr 23:1430-53. 2004
    ..Further validation of BIA is necessary to understand the mechanisms for the changes observed in acute illness, altered fat/lean mass ratios, extreme heights and body shape abnormalities...
  5. pmc Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers
    Luying Peng
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Nutr 139:1619-25. 2009
    ..This dynamic process is mediated by the activation of AMPK. These results suggest an intriguing link between SCFA and the intracellular energy sensor for the development of the intestinal barrier...
  6. pmc Accuracy of body mass index in diagnosing obesity in the adult general population
    A Romero-Corral
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, MN 55905, USA
    Int J Obes (Lond) 32:959-66. 2008
    ..Body mass index (BMI) is the most widely used measure to diagnose obesity. However, the accuracy of BMI in detecting excess body adiposity in the adult general population is largely unknown...
  7. pmc Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier
    Michael J Bernas
    Department of Surgery, University of Arizona, Tucson, Arizona, USA
    Nat Protoc 5:1265-72. 2010
    ..Monolayers of HBMVECs show characteristically high transendothelial electric resistance and have proven useful in multiple functional studies for in vitro modeling of the human blood-brain barrier...
  8. ncbi Development of bioelectrical impedance analysis prediction equations for body composition with the use of a multicomponent model for use in epidemiologic surveys
    Shumei S Sun
    Lifespan Research Center, Department of Community Health, Wright State University School of Medicine, Dayton, OH 45420, USA
    Am J Clin Nutr 77:331-40. 2003
    ..Previous studies to develop and validate bioelectrical impedance analysis (BIA) equations to predict body composition were limited by small sample sizes, sex specificity, and reliance on reference methods that use a 2-component model...
  9. ncbi Magnetic resonance electrical impedance tomography (MREIT) for high-resolution conductivity imaging
    Eung Je Woo
    Department of Biomedical Engineering, Kyung Hee University, Korea
    Physiol Meas 29:R1-26. 2008
    ..Suggestions for future research directions, possible applications in biomedicine, biology, chemistry and material science are discussed...
  10. ncbi Optimization of multiply acquired magnetic flux density B(z) using ICNE-Multiecho train in MREIT
    Hyun Soo Nam
    Department of Mathematics, Konkuk University, Seoul, Korea
    Phys Med Biol 55:2743-59. 2010
    ....
  11. pmc Measuring body composition
    J C K Wells
    MRC Childhood Nutrition Centre, Institute of Child Health, London WC1, UK
    Arch Dis Child 91:612-7. 2006
    ..Simple techniques are adequate for many purposes, and simple regional data may often be of greater value than "whole body" values obtained by more sophisticated approaches...
  12. ncbi Validation of bioelectrical impedance analysis in adolescents across different ethnic groups
    Dalia Haroun
    Childhood Nutrition Research Centre, UCL Institute of Child Health, London, UK
    Obesity (Silver Spring) 18:1252-9. 2010
    ..We found significant variability in BC between ethnic groups that was not reflected by BMI. Manufacturers' equations are unsuitable for predicting BC in multi-ethnic populations, and our new equations are recommended...
  13. pmc A new magnetic resonance electrical impedance tomography (MREIT) algorithm: the RSM-MREIT algorithm with applications to estimation of human head conductivity
    Nuo Gao
    College of Electrical Engineering, Zhejiang University, People s Republic of China
    Phys Med Biol 51:3067-83. 2006
    ....
  14. pmc Importance of whole-body bioimpedance spectroscopy for the management of fluid balance
    Peter Wabel
    Fresenius Medical Care, Bad Homburg, Germany
    Blood Purif 27:75-80. 2009
    ..Preventing the deleterious effects of fluid overload and dehydration is difficult to achieve. Objective and clinically applicable methods for the determination of a target representing normohydration are needed...
  15. ncbi Electrical properties of acupuncture points and meridians: a systematic review
    Andrew C Ahn
    Division for Research and Education in Complementary and Integrative Medical Therapies, Harvard Medical School, Boston, Massachusetts 02215, USA
    Bioelectromagnetics 29:245-56. 2008
    ..However, the preliminary findings are suggestive and offer future directions for research based on in-depth interpretation of the data...
  16. ncbi A functional in vitro model of rat blood-brain barrier for molecular analysis of efflux transporters
    Nicolas Perrière
    Institut Cochin, Département Biologie Cellulaire, Paris 75014, France
    Brain Res 1150:1-13. 2007
    ..Taken together, our results provide compelling evidence that puromycin-purified rat brain endothelial cells constitute a reliable model of the rat BBB for physiological and pharmacological characterization of BBB transporters...
  17. ncbi Regional tidal ventilation and compliance during a stepwise vital capacity manoeuvre
    Peter A Dargaville
    Department of Paediatrics, Royal Hobart Hospital and University of Tasmania, Liverpool Street, Hobart, TAS, 7000, Australia
    Intensive Care Med 36:1953-61. 2010
    ..To determine whether, during mechanical ventilation, an optimal positive end-expiratory pressure (PEEP) can be identified by measurement of regional tidal volume and compliance [V (T(reg)), C (RS(reg))]...
  18. ncbi Bioelectrical phase angle and impedance vector analysis--clinical relevance and applicability of impedance parameters
    Kristina Norman
    Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie inkl Arbeitsbereich Ernährungsmedizin Charité, Universitatsmedizin Berlin, Berlin, Germany
    Clin Nutr 31:854-61. 2012
    ..This review investigates the clinical relevance and applicability of PhA and Bioelectrical Impedance Vector Analysis (BIVA) which uses the plot of resistance and reactance normalized per height...
  19. ncbi Comparison of multifrequency bioelectrical impedance analysis with dual-energy X-ray absorptiometry for assessment of percentage body fat in a large, healthy population
    Guang Sun
    Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada, and Newlab Clinical Genetics, St John s, Canada
    Am J Clin Nutr 81:74-8. 2005
    ..However, the results of BIA validation with reference methods are contradictory, and few data are available on the influence of adiposity on the measurement of body composition by BIA...
  20. ncbi In vivo electrical conductivity imaging of a canine brain using a 3 T MREIT system
    Hyung Joong Kim
    College of Electronics and Information, Kyung Hee University, Korea
    Physiol Meas 29:1145-55. 2008
    ..The ability to acquire high-resolution conductivity images will find numerous clinical applications not supported by other medical imaging modalities. Potential applications in biology, chemistry and material science are also expected...
  21. ncbi Evaluation of oesophageal mucosa integrity by the intraluminal impedance technique
    Ricard Farre
    Translational Research Center for Gastrointestinal Disorders, Gasthuisberg, Leuven 3000, Belgium
    Gut 60:885-92. 2011
    ..Severe erosive oesophagitis is associated with low impedance baseline. We hypothesised that impedance baseline measurements could be used to evaluate changes in oesophageal mucosa integrity in man...
  22. ncbi Esophageal acid exposure decreases intraluminal baseline impedance levels
    Boudewijn F Kessing
    Department of Gastroenterology and Hepatology, Academic Medical Center Amsterdam, The Netherlands
    Am J Gastroenterol 106:2093-7. 2011
    ..The aim of this study was to investigate the baseline impedance in GERD patients, on and off proton pump inhibitor (PPI), and in healthy controls...
  23. pmc PEEP titration guided by ventilation homogeneity: a feasibility study using electrical impedance tomography
    Zhanqi Zhao
    Department of Biomedical Engineering, Furtwangen University, Jakob Kienzle Strasse 17, D 78054 Villingen Schwenningen, Germany
    Crit Care 14:R8. 2010
    ..The aim of this study was to test the feasibility of PEEP titration guided by ventilation homogeneity using the global inhomogeneity (GI) index based on electrical impedance tomography (EIT) images...
  24. ncbi Primary porcine brain microvascular endothelial cells: biochemical and functional characterisation as a model for drug transport and targeting
    Mathew Smith
    Pharmaceutical Cell Biology, Welsh School of Pharmacy, Cardiff University, Cardiff, UK
    J Drug Target 15:253-68. 2007
    ..Frozen PBMVECs therefore serve as a robust and convenient in vitro cell culture tool for research programs involving CNS drug delivery and targeting and in studies addressing blood-brain barrier transport mechanisms...
  25. ncbi Puromycin-purified rat brain microvascular endothelial cell cultures exhibit improved barrier properties in response to glucocorticoid induction
    Anthony R Calabria
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Neurochem 97:922-33. 2006
    ..The combined use of puromycin and glucocorticoid therefore provides an in vitro system that is well suited for molecular level BBB investigations...
  26. ncbi Bioelectrical impedance underestimates total and truncal fatness in abdominally obese women
    Martin Neovius
    Obesity Unit, M73, Department of Medicine, Karolinska Institute, Karolinska University Hospital, SE 141 86 Stockholm, Sweden
    Obesity (Silver Spring) 14:1731-8. 2006
    ..The secondary aim was to examine BMI and waist circumference (WC) as proxy measures for percentage total body fat (%TBF) and truncal body fat percentage (tr%BF)...
  27. ncbi Murine brain capillary endothelial cells exhibit improved barrier properties under the influence of hydrocortisone
    Christian Weidenfeller
    Institute for Biochemistry, University of Muenster, Wilhelm Klemm Str 2, 48149 Muenster, Germany
    Brain Res 1053:162-74. 2005
    ....
  28. pmc Kinetic cell-based morphological screening: prediction of mechanism of compound action and off-target effects
    Yama A Abassi
    ACEA Biosciences, 6779 Mesa Ridge Road, San Diego, CA 92121, USA
    Chem Biol 16:712-23. 2009
    ..We also identified and characterized a new antimitotic agent. Our findings indicate that the TCRP approach provides predictive mechanistic information for small molecule compounds...
  29. ncbi Body composition analysis by leg-to-leg bioelectrical impedance and dual-energy X-ray absorptiometry in non-obese and obese individuals
    Z Boneva-Asiova
    Endocrinology Unit, Central Police Hospital, Sofia, Bulgaria
    Diabetes Obes Metab 10:1012-8. 2008
    ..The aim of this study is to compare total weight, % body fat (% BF), fat mass (FM) and fat-free mass (FFM) measured by bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA)...
  30. ncbi Prediction of body cell mass, fat-free mass, and total body water with bioelectrical impedance analysis: effects of race, sex, and disease
    D P Kotler
    Gastrointestinal Division, St Luke s Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York 10025, USA
    Am J Clin Nutr 64:489S-497S. 1996
    ..These results indicate that body composition can be estimated with simple and easily applied techniques, and that the estimates are sufficiently precise for use in clinical investigation and practice...
  31. ncbi Regional ventilation by electrical impedance tomography: a comparison with ventilation scintigraphy in pigs
    Jose Hinz
    Department of Anesthesiology, Emergency, University of Gottingen, Gottingen, Germany
    Chest 124:314-22. 2003
    ..The validation of electrical impedance tomography (EIT) for measuring regional ventilation distribution by comparing it with single photon emission CT (SPECT) scanning...
  32. ncbi Accuracy of bioelectrical impedance consumer devices for measurement of body composition in comparison to whole body magnetic resonance imaging and dual X-ray absorptiometry
    Anja Bosy-Westphal
    Institut fur Humanernahrung und Lebensmittelkunde, Christian Albrechts Universitat, Kiel, Germany
    Obes Facts 1:319-24. 2008
    ....
  33. ncbi Esophageal pH-impedance monitoring in patients with therapy-resistant reflux symptoms: 'on' or 'off' proton pump inhibitor?
    Gerrit J M Hemmink
    Department of Gastroenterology, Sint Antonius Hospital, Nieuwegein, The Netherlands
    Am J Gastroenterol 103:2446-53. 2008
    ..Until now, it is unclear whether combined pH-impedance monitoring in these patients should be performed on or off PPI...
  34. ncbi Validity of leg-to-leg bioelectrical impedance analysis to estimate body fat in obesity
    Celia Lloret Linares
    Department of Nutrition, Pitié Salpêtrière Hospital AP HP, University Pierre et Marie Curie Paris 6, 83, Boulevard de l Hopital, 75013, Paris, France
    Obes Surg 21:917-23. 2011
    ....
  35. ncbi Combined QCM-D and EIS study of supported lipid bilayer formation and interaction with pore-forming peptides
    Elisabeth Briand
    Department of Applied Physics, Chalmers University of Technology, 412 96 Goteborg, Sweden
    Analyst 135:343-50. 2010
    ..This information will be particularly important for the continued detailed investigation of interactions at model membrane surfaces...
  36. ncbi Conductivity and current density image reconstruction using harmonic Bz algorithm in magnetic resonance electrical impedance tomography
    Suk Hoon Oh
    Graduate School of East West Medical Sciences, Kyung Hee University, Korea
    Phys Med Biol 48:3101-16. 2003
    ..The results suggest that in vitro and in vivo experimental studies with animal subjects are feasible. Further studies are requested to reduce the amount of injection current down to less than 1 mA for human subjects...
  37. ncbi Measurement of ion diffusion using magnetic resonance electrical impedance tomography
    Mark J Hamamura
    Tu and Yuen Center for Functional Onco Imaging, University of California, 164 Irvine Hall, Irvine, CA 92697 5020, USA
    Phys Med Biol 51:2753-62. 2006
    ..The results indicate that MREIT was able to monitor the changing conductivity and concentration distributions resulting from the diffusion of ions within the agarose gel phantom...
  38. ncbi Prediction of fatness by standing 8-electrode bioimpedance: a multiethnic adolescent population
    John D Sluyter
    Department of Pacific Health, University of Auckland, Auckland, New Zealand
    Obesity (Silver Spring) 18:183-9. 2010
    ..In conclusion, equations for fatness estimation using BIA(8) developed for our sample perform better than reliance on the manufacturer's estimates. The relationship between BIA and body composition in adolescents is ethnicity dependent...
  39. ncbi A new BIA equation estimating the body composition of young children
    Jody L Clasey
    Department of Kinesiology and Health Promotion, University of Kentucky, Lexington, Kentucky, USA
    Obesity (Silver Spring) 19:1813-7. 2011
    ....
  40. ncbi Experimental performance evaluation of multi-echo ICNE pulse sequence in magnetic resonance electrical impedance tomography
    Atul S Minhas
    Department of Biomedical Engineering, Kyung Hee University, Yongin, Korea
    Magn Reson Med 66:957-65. 2011
    ..The proposed method will be advantageous for an imaging region with long T2 values such as the brain and knee. Depending on T2 values, we suggest using two or three echoes in future experimental studies...
  41. ncbi Comparison of different methods to define regions of interest for evaluation of regional lung ventilation by EIT
    Sven Pulletz
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Physiol Meas 27:S115-27. 2006
    ..Simple segmental ROIs are less convenient because of the low ventilation-related signal component in the dorsal region...
  42. ncbi Monitoring human mesenchymal stromal cell differentiation by electrochemical impedance sensing
    Michael Angstmann
    Mannheim University of Applied Sciences, Biotechnology, Mannheim, Germany
    Cytotherapy 13:1074-89. 2011
    ..However, standardized quality control assays monitoring differentiation that are non-invasive and continuous over time are lacking...
  43. ncbi Self-assembly-induced formation of high-density silicon oxide memristor nanostructures on graphene and metal electrodes
    Woon Ik Park
    Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology KAIST, 291 Daehak ro, Yuseong Gu, Daejeon 305 701, Republic of Korea
    Nano Lett 12:1235-40. 2012
    ..This approach offers a very convenient pathway to fabricate ultrahigh-density resistive memory devices without relying on high-cost lithography and pattern-transfer processes...
  44. ncbi Differentiation among basal cell carcinoma, benign lesions, and normal skin using electric impedance
    Daryl G Beetner
    Department of Electrical and Computer Engineering, University of Missouri Rolla, 126 Emerson Electric Company Hall, Rolla, MO 65409, USA
    IEEE Trans Biomed Eng 50:1020-5. 2003
    ..Results suggest that electrical impedance could be used to provide rapid and noninvasive differentiation of BCC from similar looking benign lesions...
  45. pmc Occludin as direct target for glucocorticoid-induced improvement of blood-brain barrier properties in a murine in vitro system
    Carola Förster
    Institute of Anatomy and Cell Biology, University of Wurzburg, Koellikerstrasse 6, D 97070 Wurzburg, Germany
    J Physiol 565:475-86. 2005
    ..This study thus provides insights into the molecular processes of barrier genesis, and may help to elucidate mechanisms of brain pathology at the microvascular level...
  46. ncbi Uniqueness and reconstruction in magnetic resonance-electrical impedance tomography (MR-EIT)
    Y Ziya Ider
    Department of Electrical and Electronics Engineering, Bilkent University, Ankara, Turkey
    Physiol Meas 24:591-604. 2003
    ..They can also be used to easily obtain slice and field-of-view images from a 3D object. 2D simulations are made to illustrate the performance of the algorithms...
  47. ncbi Assessment of body fat composition disturbances by bioimpedance analysis in HIV-infected adults
    P Freitas
    Endocrinology Department, Hospital de São João and University of Porto Medical School, Alameda Hernani Monteiro, 4200 Porto, Portugal
    J Endocrinol Invest 34:e321-9. 2011
    ..In a clinical setting, BIA is an easy and useful tool to evaluate fat mass and FFM and gives us a picture of BC that was not possible with anthropometry...
  48. pmc Real-time label-free monitoring of adipose-derived stem cell differentiation with electric cell-substrate impedance sensing
    Pierre O Bagnaninchi
    Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
    Proc Natl Acad Sci U S A 108:6462-7. 2011
    ....
  49. ncbi The significance of measuring body fat percentage determined by bioelectrical impedance analysis for detecting subjects with cardiovascular disease risk factors
    Kentaro Yamashita
    Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 8550, Japan
    Circ J 76:2435-42. 2012
    ..Body fat percentage (BF%) determined by bioelectrical impedance analysis is widely used at home and in medical check-ups. However, the clinical significance of measuring BF% has not been studied in detail...
  50. ncbi MREIT conductivity imaging of the postmortem canine abdomen using CoReHA
    Kiwan Jeon
    Department of Mathematical Sciences, KAIST, Daejeon, Korea
    Physiol Meas 30:957-66. 2009
    ..We elaborate, as an example, that conductivity images of the kidney show clear contrast among cortex, internal medulla, renal pelvis and urethra. We end this paper with a brief discussion on future work using different animal models...
  51. pmc Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice
    Ece A Mutlu
    Department of Medicine, Section of Gastroenterology and Nutrition Rush University Medical College, 1725 W Harrison Street, Chicago, IL 60612, USA
    Part Fibre Toxicol 8:19. 2011
    ..PM can gain access to the gastrointestinal (GI) tract via swallowing of air or secretions from the upper airways or mucociliary clearance of inhaled particles...
  52. ncbi Cytotoxicity of metal and semiconductor nanoparticles indicated by cellular micromotility
    Marco Tarantola
    Institute of Physical Chemistry, University of Mainz, Jakob Welder Weg 11, 55128 Mainz, Germany
    ACS Nano 3:213-22. 2009
    ..The method is validated by conventional cytotoxicity testing and accompanied by fluorescence and dark-field microscopy to visualize changes in the cytoskeleton integrity and to determine the location of the particles within the cell...
  53. ncbi GREIT: a unified approach to 2D linear EIT reconstruction of lung images
    Andy Adler
    Systems and Computer Engineering, Carleton University, Ottawa, ON, Canada
    Physiol Meas 30:S35-55. 2009
    ..All software and data to implement and test the algorithm have been made available under an open source license which allows free research and commercial use...
  54. pmc Two-path impedance spectroscopy for measuring paracellular and transcellular epithelial resistance
    Susanne M Krug
    Institute of Clinical Physiology, Charite, Campus Benjamin Franklin, Freie Universität and Humboldt Universität, Berlin, Germany
    Biophys J 97:2202-11. 2009
    ..The underlying prerequisites and the applicability as a routine method were verified on cell lines of different tightness including HT-29/B6 colon cells and Madin-Darby canine kidney tubule cells C7 and C11...
  55. ncbi The added value of impedance-pH monitoring to Rome III criteria in distinguishing functional heartburn from non-erosive reflux disease
    Edoardo Savarino
    Division of Gastroenterology, Department of Internal Medicine, University of Genoa, Genoa, Italy Division of Gastroenterology, IRCCS Istituto Clinico Humanitas, Milan, Italy
    Dig Liver Dis 43:542-7. 2011
    ..These criteria underestimated the role of non-acid reflux...
  56. ncbi Acidic bile salts modulate the squamous epithelial barrier function by modulating tight junction proteins
    Xin Chen
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Am J Physiol Gastrointest Liver Physiol 301:G203-9. 2011
    ..In conclusion, acidic bile salts disrupted the squamous epithelial barrier function partly by modulating the amounts of claudin-1 and claudin-4. These results provide new insights for understanding the role of TJ proteins in esophagitis...
  57. ncbi Acid modulates the squamous epithelial barrier function by modulating the localization of claudins in the superficial layers
    Tadayuki Oshima
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Lab Invest 92:22-31. 2012
    ..In conclusion, TJs are located in the superficial layers of the esophagus, and acid stimulation disrupts barrier function, at least in part by modulating the amount and localization of claudin-4 in the superficial layers...
  58. ncbi Perception of dysphagia: lack of correlation with objective measurements of esophageal function
    A Lazarescu
    Centre for Gastroenterological Research, KU Leuven, Leuven, Belgium
    Neurogastroenterol Motil 22:1292-7, e336-7. 2010
    ....
  59. ncbi A new simple method for the measurement of visceral fat accumulation by bioelectrical impedance
    Miwa Ryo
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetes Care 28:451-3. 2005
  60. pmc Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism
    A Seth
    Dept of Physiology, Univ of Tennessee Health Science Center, Memphis, TN 38163, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1060-9. 2008
    ..These studies demonstrate that probiotic-secretory proteins protect the intestinal epithelial tight junctions and the barrier function from hydrogen peroxide-induced insult by a PKC- and MAP kinase-dependent mechanism...
  61. ncbi Prediction of fat-free mass by bioimpedance analysis in migrant Asian Indian men and women: a cross validation study
    E C Rush
    Division of Sport and Recreation, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand
    Int J Obes (Lond) 30:1125-31. 2006
    ..However, bioimpedance-based prediction equations have been developed in predominantly white populations and little information is available on their usefulness in Asian Indian populations...
  62. ncbi Effects of butyrate on intestinal barrier function in a Caco-2 cell monolayer model of intestinal barrier
    Luying Peng
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Pediatr Res 61:37-41. 2007
    ..e. whereas low concentrations of butyrate may be beneficial in promoting intestinal barrier function, excessive butyrate may induce severe intestinal epithelial cell apoptosis and disrupt intestinal barrier...
  63. ncbi Three-dimensional electrical impedance tomography of human brain activity
    T Tidswell
    Department of Clinical Neurophysiology, Middlesex Hospital, London W1N 8AA, United Kingdom
    Neuroimage 13:283-94. 2001
    ..The final images contained spatial noise and strategies to reduce this in future work are presented...
  64. ncbi Serum-derived factors weaken the barrier properties of cultured porcine brain capillary endothelial cells in vitro
    Thorsten Nitz
    Institut fur Biochemie, Westfalische Wilhelms Universitat Munster, Wilhelm Klemm Strasse 2, 48149 Munster, Germany
    Brain Res 981:30-40. 2003
    ..Although the structure of the 67 kDa factor could not be analysed, this finding is of importance for in vitro models not only of the blood-brain barrier mostly using serum-containing media...
  65. ncbi Current constrained voltage scaled reconstruction (CCVSR) algorithm for MR-EIT and its performance with different probing current patterns
    Ozlem Birgul
    Department of Electrical and Electronics Engineering, Middle East Technical University, 06531 Ankara, Turkey
    Phys Med Biol 48:653-71. 2003
    ..The spatial resolution is limited by the larger element size of the finite element mesh and twice the magnetic resonance image pixel size...
  66. ncbi Validity of total and segmental impedance measurements for prediction of body composition across ethnic population groups
    P Deurenberg
    Department of Nutrition and Epidemiology, Wageningen University, The Netherlands
    Eur J Clin Nutr 56:214-20. 2002
    ..To test the impact of body build factors on the validity of impedance-based body composition predictions across (ethnic) population groups and to study the suitability of segmental impedance measurements...
  67. pmc Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramides
    Kelly S Schweitzer
    Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202 5120, USA
    Am J Physiol Lung Cell Mol Physiol 301:L836-46. 2011
    ..Amelioration of endothelial permeability may alleviate lung and systemic vascular dysfunction associated with smoking-related chronic obstructive lung diseases...
  68. ncbi Epithelial barrier characteristics and expression of cell adhesion molecules in proximal tubule-derived cell lines commonly used for in vitro toxicity studies
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, 555, Downers Grove, IL 60515, USA
    Toxicol In Vitro 20:942-53. 2006
    ....
  69. ncbi African trypanosome interactions with an in vitro model of the human blood-brain barrier
    Dennis J Grab
    Department of Pediatrics, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    J Parasitol 90:970-9. 2004
    ..This is the first demonstration of paracellular traversal of African trypanosomes across the BBB. Further studies are required to determine the mechanism of BBB traversal by these parasites at the cellular and molecular level...
  70. ncbi Influence of nasogastric tubes on gastroesophageal reflux in preterm infants: a multiple intraluminal impedance study
    Corinna S Peter
    Department of Neonatology and Pediatric Pulmonology, Hannover Medical School, Hannover, Germany
    J Pediatr 141:277-9. 2002
    ..There were 72 (range, 40-145) reflux episodes with the esophageal placement and 122 (range, 60-147) during the gastric position (P <.01)...
  71. ncbi Equipotential projection-based magnetic resonance electrical impedance tomography and experimental realization
    Mahir S Ozdemir
    Department of Electrical and Electronics Engineering, Middle East Technical University, 06531 Ankara, Turkey
    Phys Med Biol 49:4765-83. 2004
    ..The proposed technique is evaluated both on simulated and measured data for conductor and insulator objects...
  72. ncbi Bioelectrical impedance phase angle in clinical practice: implications for prognosis in advanced colorectal cancer
    Digant Gupta
    Cancer Treatment Centers of America at Midwestern Regional Medical Center, Zion, IL 60099, USA
    Am J Clin Nutr 80:1634-8. 2004
    ....
  73. ncbi Discriminating between body fat and fluid changes in the obese adult using bioimpedance vector analysis
    A Piccoli
    Institute of Internal Medicine, Division of Nephrology, University of Padova, Italy
    Int J Obes Relat Metab Disord 22:97-104. 1998
    ..We used an assumption-free, graphical method for interpreting body weight variation in obesity using bioelectrical measurements...
  74. ncbi Prediction of body fat in 12-y-old African American and white children: evaluation of methods
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 76:980-90. 2002
    ..The prevalence of obesity is increasing in children. Validation of methods of predicting fatness in African American and white children could help to identify children at high risk...
  75. ncbi Validation of foot-to-foot bioelectrical impedance analysis with dual-energy X-ray absorptiometry in the assessment of body composition in young children: the EarlyBird cohort
    Joanne Hosking
    Department of Endocrinology and Metabolism, Peninsula Medical School, Plymouth Campus, Plymouth, UK
    Br J Nutr 96:1163-8. 2006
    ..Therefore, BIA may be useful for large-scale studies but is not interchangeable with DEXA and should be interpreted with caution in individuals...
  76. pmc Measurement of body fat using leg to leg bioimpedance
    R Y Sung
    Department of Paediatrics, The Chinese University of Hong Kong, 6 F Clinical Science Building, Prince of Wales Hospital, Shatin, Hong Kong
    Arch Dis Child 85:263-7. 2001
    ..2) To establish a reference range of percentage body fat in Hong Kong Chinese children...
  77. ncbi Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs
    Luca Cucullo
    Center for Cerebrovascular Research, Cleveland, Ohio, USA
    Epilepsia 48:505-16. 2007
    ....
  78. ncbi Comparison of methods to assess body composition changes during a period of weight loss
    Madlyn I Frisard
    Pennington Biomedical Research Center, Baton Rouge, LA 70810, USA
    Obes Res 13:845-54. 2005
    ..To assess the accuracy of body composition measurements by air displacement plethysmography and bioelectrical impedance analysis (BIA) compared with DXA during weight loss...
  79. ncbi Electrical conductivity imaging using gradient B, decomposition algorithm in magnetic resonance electrical impedance tomography (MREIT)
    Chunjae Park
    College of Electronics and Information, Kyung Hee University, Kyungki 449 701, Korea
    IEEE Trans Med Imaging 23:388-94. 2004
    ..Numerical simulations with added random noise of realistic amounts show the feasibility of the algorithm in practical applications and also its robustness against measurement noise...
  80. pmc The h channel mediates location dependence and plasticity of intrinsic phase response in rat hippocampal neurons
    Rishikesh Narayanan
    Center for Learning and Memory, The University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 28:5846-60. 2008
    ..Our analyses and results also establish impedance as a powerful measure of intrinsic dynamics and excitability, given that it quantifies temporal relationships among signals and excitability as functions of input frequency...
  81. ncbi MMPs contribute to TNF-alpha-induced alteration of the blood-cerebrospinal fluid barrier in vitro
    Patrick Zeni
    Institut fur Biochemie, Westfalische Wilhelms Universitat, Wilhelm Klemm Strasse 2, D 48149 Munster, Germany
    Am J Physiol Cell Physiol 293:C855-64. 2007
    ..Thus TNF-alpha may mediate the binding of leukocytes to cellular adhesion molecules and the transmigration across the blood-CSF barrier...
  82. ncbi Abnormalities of bioimpedance measures in overweight and obese hemodialyzed patients
    B Guida
    Department of Neuroscience Physiology Nutrition Section, University Federico II, Naples, Italy
    Int J Obes Relat Metab Disord 25:265-72. 2001
    ....
  83. ncbi Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons
    J C Magee
    Neuroscience Center, Louisiana State University Medical Center, New Orleans, Louisiana 70112, USA
    J Neurosci 18:7613-24. 1998
    ..Overall, Ih acts to dampen dendritic excitability, but its largest impact is on the subthreshold range of membrane potentials where the integration of inhibitory and excitatory synaptic inputs takes place...
  84. ncbi Evaluation of an electrical impedance tomography-based Global Inhomogeneity Index for pulmonary ventilation distribution
    Zhanqi Zhao
    Section for Experimental Anesthesiology, Department of Anesthesiology and Critical Care Medicine, University Medical Center, Freiburg, Germany
    Intensive Care Med 35:1900-6. 2009
    ..To evaluate the plausibility, stability, and interindividual comparability of the global inhomogeneity index (GI) based on electrical impedance tomography (EIT)...
  85. ncbi EIT reconstruction algorithms: pitfalls, challenges and recent developments
    William R B Lionheart
    Department of Mathematics, UMIST, Manchester, M60 1QD, UK
    Physiol Meas 25:125-42. 2004
    ..We also suggest common pitfalls or 'inverse crimes' to avoid...
  86. ncbi Real-time monitoring of morphological changes in living cells by electronic cell sensor arrays: an approach to study G protein-coupled receptors
    Naichen Yu
    ACEA Biosciences, 11585 Sorrento Valley Road, San Diego, California 92121, USA
    Anal Chem 78:35-43. 2006
    ..Moreover, the noninvasive nature of the readout offers the added advantage of performing multiple treatments in the same well to study events such as desensitization and receptor cross-talk...
  87. ncbi Magnetic resonance electrical impedance tomography (MREIT): simulation study of J-substitution algorithm
    Ohin Kwon
    Department of Mathematics, Konkuk University, Seoul, Korea
    IEEE Trans Biomed Eng 49:160-7. 2002
    ..MREIT provides accurate high-resolution cross-sectional resistivity images making resistivity values of various human tissues available for many biomedical applications...
  88. ncbi Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture
    Oscar R Colegio
    Department of Cell Biology, Yale University, New Haven, Connecticut 06520, USA
    Am J Physiol Cell Physiol 284:C1346-54. 2003
    ..These results support a model in which the claudins create paracellular channels and the first extracellular domain is sufficient to determine both paracellular charge selectivity and TER...
  89. ncbi Use of bioelectrical impedance analysis to assess body composition in rural Gambian children
    M Prins
    Wageningen University and Research Centre, Wageningen, The Netherlands
    Eur J Clin Nutr 62:1065-74. 2008
    ....
  90. ncbi Characterizing spinal muscular atrophy with electrical impedance myography
    Seward B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Shapiro 810, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Muscle Nerve 42:915-21. 2010
    ..These results confirm that EIM can accurately categorize patients with SMA. Because EIM requires no patient effort and is rapid to apply, it may serve a useful role in future SMA clinical trials...
  91. ncbi Use of anisotropic modelling in electrical impedance tomography: description of method and preliminary assessment of utility in imaging brain function in the adult human head
    Juan Felipe P J Abascal
    Laboratoire des Signaux et Systèmes, SUPELEC, Gif sur Yvette, France
    Neuroimage 43:258-68. 2008
    ..This suggests that incorporation of anisotropy in numerical models used for image reconstruction is likely to improve EIT image quality...
  92. pmc Reflux events detected by pH-MII do not determine fundoplication outcome
    Rachel Rosen
    Center for Motility and Functional Gastrointestinal Disorders, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Pediatr Gastroenterol Nutr 50:251-5. 2010
    ..The aim of the study was to determine predictors of fundoplication outcome including acid and nonacid reflux burden...
  93. pmc Nedd4-2 interacts with occludin to inhibit tight junction formation and enhance paracellular conductance in collecting duct epithelia
    Nandita S Raikwar
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, 52242, USA
    Am J Physiol Renal Physiol 299:F436-44. 2010
    ..In summary, we demonstrate that Nedd4-2 plays a role in tight junction assembly and the regulation of paracellular conductance in the collecting duct...
  94. ncbi Reference distribution of the bioelectrical impedance vector in healthy term newborns
    Ana V B Margutti
    University of Ribeirao Preto, Sao Paulo, Brazil
    Br J Nutr 104:1508-13. 2010
    ..BIVA and PA permit an assessment without the need to know body weight and the prediction error of conventional impedance formulas...
  95. ncbi Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3beta
    Feng Liu
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    FASEB J 16:950-62. 2002
    ....
  96. ncbi In vitro evaluation of the toxicity induced by nickel soluble and particulate forms in human airway epithelial cells
    Efrat Forti
    European Centre for the Validation of Alternative Methods, Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra Va, Italy
    Toxicol In Vitro 25:454-61. 2011
    ..Furthermore, we have demonstrated that the induced effects by Ni compounds can be partially attributed to the increase in Ni ions (Ni(2+)) intracellular levels...
  97. ncbi Magnetic resonance electrical impedance tomography for monitoring electric field distribution during tissue electroporation
    M Kranjc
    Faculty of Electrical Engineering, University of Ljubljana, SI 1000 Ljubljana, Slovenia
    IEEE Trans Med Imaging 30:1771-8. 2011
    ....
  98. ncbi Addition of pH-impedance monitoring to standard pH monitoring increases the yield of symptom association analysis in infants and children with gastroesophageal reflux
    Clara M Loots
    Academic Medical Centre, Amsterdam, The Netherlands
    J Pediatr 154:248-52. 2009
    ..To assess the additional yield of combined multichannel intraluminal pH-impedance (pH-MII) monitoring compared with standard pH monitoring on gastroesophageal reflux (GER) symptom associations in infants and children...
  99. ncbi Comparison of direct body composition assessment methods in patients with chronic heart failure
    Antigone Oreopoulos
    School of Public Health, University of Alberta, Edmonton, Alberta, Canada
    J Card Fail 16:867-72. 2010
    ..We examined the validity of leg-to-leg bioelectrical impedance analysis (BIA) and near-infrared interactance (NIR) to assess body composition in chronic heart failure (CHF) patients...
  100. ncbi Interleukin-1beta-induced disruption of barrier function in cultured human corneal epithelial cells
    Kazuhiro Kimura
    Department of Ocular Pathophysiology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 50:597-603. 2009
    ..We examined the effects of the proinflammatory cytokine interleukin (IL)-1beta on AJs and TJs as well as on barrier function in simian virus 40-transformed human corneal epithelial (HCE) cells...
  101. ncbi Gravity-dependent ventilation distribution in rats measured with electrical impedance tomography
    Daniel Rooney
    Paediatric Critical Care Research Group, Paediatric Intensive Care Unit, Mater Children s Hospital, South Brisbane QLD, Australia
    Physiol Meas 30:1075-85. 2009
    ..Gravity had little impact on regional filling. Ventilation distribution in rats is gravity dependent, whereas regional filling characteristics are dependent on anatomy...

Research Grants66

  1. Breast Cancer Diagnosis by Electrical Impedance Imaging
    JONATHAN NEWELL; Fiscal Year: 2009
    ..Success of such a trial would reduce the need for biopsy and increase the detection of tumors at an earlier stage, which would reduce the morbidity and mortality of breast cancer. ..
  2. Astrocyte senescence and HIV-associated neurocognitive disorders
    ELIZABETH PATRICIA CROWE; Fiscal Year: 2013
    ....
  3. Biomimetic Microsystem for High Throughput Evaluation of Engineered Nanomaterials
    Robert M Worden; Fiscal Year: 2010
    ....
  4. Body Composition and Energy Utilization in Spinal Muscular Atrophy
    Douglas Michael Sproule; Fiscal Year: 2012
    ..We will also study muscle imaging and electrical impedance as potential biomarkers of disease progression;the development of such biomarkers is of critical importance in the acceleration of clinical trials in SMA. ..
  5. Biology of desmosome-gap junctions in the testis
    Dolores D Mruk; Fiscal Year: 2010
    ..The study of desmosome-gap junctions in the testis will yield new and important insights into the biology of spermatogenesis. ..
  6. A device for rapid, painless, bedside muscle evaluation of children
    JOSE LUIS BOHORQUEZ; Fiscal Year: 2012
    ..Thus, the overall goal of this project is to develop a handheld, noninvasive electrical impedance device that can perform accurate, rapid assessments of muscle health in children. ..
  7. PROTEINS OF THE ENDOTHELIAL CELL SURFACE
    Jordan S Pober; Fiscal Year: 2013
    ..Successful completion of these aims may lead to effective therapeutic approaches to control capillary leak. ..
  8. Biosensing Devices for Cytotoxic and Genotoxic Assessment of Nanomaterials
    Chenzhong Li; Fiscal Year: 2012
    ..The electrical impedance devices have important implications in solving problems in many biomedical areas such as nanotechnology based drug design and delivery, cancer diagnosis and therapy, and biomaterial development and applications. ..
  9. Noninvasive Assessment of Neuromuscular Disease using Electrical Impedance
    Jeremy M Shefner; Fiscal Year: 2013
    ....
  10. Optimizing Bioactive Hydrogels to Control Angiogenesis and Inflammation in Functi
    JOACHIM B KOHN; Fiscal Year: 2010
    ..To overcome the difficulties in studying inflammatory and angiogenic responses to biomaterials, several high risk in vitro and in vivo methods will be utilized. ..
  11. Noninvasive assessment of neuromuscular diseases using electrical impedance
    Seward B Rutkove; Fiscal Year: 2010
    ..Thus, the overall goal of this project is to develop a handheld, noninvasive electrical impedance device that can perform accurate, rapid assessments of muscle health. ..
  12. Sphingolipid Signaling in Endothelial Function
    Menq Jer Lee; Fiscal Year: 2012
    ..The success of this proposed research will not only lead to the discovery of novel mechanisms mediating GPCR signaling, but may also develop into future therapeutic usages. ..
  13. Electrical Impedance Myography for the Assessment of Neck and Low Back Pain
    JOSE LUIS BOHORQUEZ; Fiscal Year: 2013
    ..With the completion of these aims, CMD, will be well-poised submit a 510k application to FDA and pursue Phase 3 funding for commercialization. ..
  14. EIT: a non-radiating functional imaging method for cystic fibrosis
    JENNIFER LYNN MUELLER; Fiscal Year: 2013
    ..Regional changes in air trapping and consolidation from pre to post treatment as indicated by the EIT images will be calculated, with subjects serving as their own control. ..
  15. In Vitro Human Tissue Model for Intravaginal Drug Delivery
    Seyoum Ayehunie; Fiscal Year: 2010
    ..This proposal will optimize a highly differentiated, human vaginal tissue model to facilitate such studies. ..
  16. Electrical Impedance Myography in an Animal Model
    Seward B Rutkove; Fiscal Year: 2013
    ..With the successful completion of this research, we will have greatly expanded our tools to effectively apply and interpret EIM in both pre-clinical animal studies and human clinical research. ..
  17. Shear regulated differentiation of hPSCs to brain endothelial cells
    Sean P Palecek; Fiscal Year: 2013
    ..Ascertain the effects of shear stress on hPSC-derived BMEC phenotype induction and maintenance 3. Determine the roles of PECAM-1 and VE-cadherin in shear-induced differentiation of BMECs ..
  18. Leukotrienes and blood-brain barrier
    Kwang S Kim; Fiscal Year: 2013
    ..We propose to determine the contribution of the host molecules involving leukotrienes to microbial traversal of the blood-brain barrier. ..
  19. Multi-excitation magnetoacoustic imaging of tissue conductivities
    Bin He; Fiscal Year: 2013
    ..The successful development of a high-resolution, non-ionizing, cost-effective electrical impedance imaging system will have a significant impact to screening and early detection of breast cancer. ..
  20. Nanoparticle Effects on Epithelial Cell Protein Expression and Function
    Frank A Witzmann; Fiscal Year: 2012
    ..In addition, the studies will correlate the changes in protein expression with changes in cellular function at both toxic and subtoxic levels. ..
  21. Breast Cancer Risk Stratification with Resonant Electrical Impedance Spectroscopy
    David Gur; Fiscal Year: 2010
    ..If successful, this proposal will have a large public health impact via increased early detection of breast cancer. ..
  22. A Novel Ultrasound Phased Array and Sonication Method for Stroke Treatments
    Kullervo Hynynen; Fiscal Year: 2012
    ..During this research we plan to develop such a system and perform all of the experiments needed prior to starting clinical trials. This research may have a major impact on patient care. ..
  23. Phase 1b Trial of stem cells in ALS
    Seward B Rutkove; Fiscal Year: 2013
    ....
  24. STAT Palm-Sized Blood Counter
    EUGENE YAN HO CHAN; Fiscal Year: 2013
    ..The resulting product can be utilized in a wide- range of settings including ambulances, inpatient rooms, operating rooms, medical offices, and resource- starved settings. ..
  25. Electrical impedance myography and quantitative ultrasound in Duchenne muscular d
    Seward B Rutkove; Fiscal Year: 2013
    ..With the successful completion of this work, we will have set the stage for the use of one or both of these techniques as the preferred biomarkers in Phase II clinical trials in DMD. ..
  26. Novel Mucosal Models Predictive of Microbicide Safety
    Marla J Keller; Fiscal Year: 2012
    ..In addition, these models may provide a means to test the safety of microbicides in healthy women as well as those with underlying STIs. ..
  27. Functional characterization of the novel protein nephrocystin-5
    JOHN F O apos TOOLE; Fiscal Year: 2010
    ....
  28. ALTERNATIVE BREAST CANCER IMAGING MODALITIES
    Keith D Paulsen; Fiscal Year: 2010
    ..abstract_text> ..
  29. Assessing Indeterminate Thyroid Nodules With Electrical Impedance Measurements
    Mitchell E Tublin; Fiscal Year: 2012
    ..We will assess the ability of this technology to accurately characterize these indeterminate nodules as benign or malignant prior to a "diagnostic" surgery. ..
  30. Miniaturized Laser Sources for Optical Neuroprostheses
    MATTHEW DUMMER; Fiscal Year: 2012
    ..In the example of cochlear implants, this innovation would improve the quality of the implants, particularly in noisy environments or in appreciating music. ..
  31. LLISA: ???Liposome-Linked Immunosorbant Assay??? for Detection of HIV Viral Load
    Abraham P Lee; Fiscal Year: 2013
    ..With the integration of these two sets of expertise, we expect to address the grand challenge of developing point-of-care viral load assays. ..
  32. Optimal Electrode Geometries for Efficient and Selective Deep Brain Stimulation
    Bryan Howell; Fiscal Year: 2013
    ..In the long-term, the research will help transform electrode design from an ad hoc practice to a calculated science. ..
  33. Proof-of-Concept for Card-Based CD4 Cell Counting
    HAROLD EDWARD AYLIFFE; Fiscal Year: 2010
    ..white blood cell count, absolute CD4+ T cell count, and percent CD4 count using a new volumetric combination electric impedance/fluorescence sensor contained on a disposable microfluidic cassette...
  34. Intraoperative Surgical Margin Assessment with Electrical Impedance Spectroscopy
    RYAN JOSEPH HALTER; Fiscal Year: 2013
    ..Overall, this will further advance the study of electrical property signatures of normal and diseased prostate in vivo and help to translate this technology to the clinic. ..
  35. PCR-independent Reagent-Free Nucleic Acid Detection
    HAROLD GEORGE MONBOUQUETTE; Fiscal Year: 2012
    ....
  36. Novel Methods for Cardiac Micro-Impedance Measurement
    ANDREW EMIL POLLARD; Fiscal Year: 2013
    ..Thesaurus Terms: electrical impedance, electrical measurement, heart electrical activity, interstitial, intracellular, method development, cardiac myocyte, electrical conductance, membrane model, myocardium, electrode. ..
  37. Prostate Cancer Screening With Electrical Impedance Measurements
    Alexander Hartov; Fiscal Year: 2010
    ..We also will develop new electronics and reconstruction techniques applicable to this configuration. This project capitalizes on our group's extensive experience in impedance imaging. ..
  38. A Multi-functional Optical Impedance Microscope for Live Cell Imaging
    Shaopeng Wang; Fiscal Year: 2012
    ..The success of this project will provide a new tool that has a broad range of applications on cell dynamic studies. ..
  39. Biomimetic Self-Adhesive Dry EEG Electrodes
    Mingui Sun; Fiscal Year: 2013
    ..In order to translate our laboratory findings to successful clinical practice, we will also investigate methods to apply GT electrodes to the existing EEG systems. ..
  40. Impedance Changes as an Indicator of Successful Skin Electroporative DNA delivery
    Mark J Jaroszeski; Fiscal Year: 2012
    ..It will also be applicable for delivering DNA based vaccines. ..
  41. Cryptococcus traversal of Brain Endothelial cells
    Kwang Kim; Fiscal Year: 2007
    ..neoformans traversal of HBMEC monolayers and will be the basis of future investigations to characterize microbial-host interactions that are relevant to the pathogenesis of cryptococcal meningitis/meningoencephalitis. ..
  42. Electrical Property Based Image-guided Prostate Biopsy
    RYAN JOSEPH HALTER; Fiscal Year: 2010
    ....
  43. Biophysics of Acupuncture: Electrical Properties of Loose Connective Tissue
    Andrew Ahn; Fiscal Year: 2009
    ..Each of these skills will be critical to the candidate's long-term goal of becoming an independent clinical investigator with a focus on the biophysics of acupuncture. ..
  44. A Noninvasive Real-Time Monitoring System for Pulmonary Function Assessment
    JEFFREY ASHE; Fiscal Year: 2013
    ..Upon successful completion, the clinician will have access to a device that will provide a 3-D regional ventilation/perfusion (V/Q) mismatch data, a 3-D regional indicator of atelectasis, and regional perfusion data. ..
  45. Commercialization of Magneto-Nanosensor Immunoassay Platform for Cancer Diagnosis
    Sebastian J Osterfeld; Fiscal Year: 2013
    ....
  46. EXOCYTIC INSERTION OF POTASSIUM CHANNELS IN MEMBRANES
    William Moran; Fiscal Year: 2001
    ..These studies will provide important information about regulation of the pump-leak model that generates membrane potentials and controls cell volume in nutrient- stimulated Na-absorbing epithelia. ..
  47. Measuring Intra/Extracellular Volume and Hemodynamics
    Leslie Montgomery; Fiscal Year: 2003
    ..It is hoped that the instrument may be further validated during statistically significant clinical trials during a Phase II NIH SBIR grant. ..
  48. FAT AND FAT FREE BODY COMPOSITION IN OLDER MEN AND WOMEN
    Scott Going; Fiscal Year: 1991
    ....
  49. Electrical System for Rapid Bacterial Cultures
    Paul W Todd; Fiscal Year: 2011
    ..Techshot and colleagues at the University of Missouri have proposed an electrical measurement device that can detect bacterial growth in blood in a few hours, rather than the 1 or 2 days currently (which is sometimes too late). ..
  50. A novel physiologically realistic microfluidic in-vitro blood-brain barrier model
    BALABHASKAR PRABHAKARPANDIAN; Fiscal Year: 2013
    ..A multi-disciplinary partnership with expertise in engineering and biology has been assembled for successful completion of the project. ..
  51. FAT AND FAT-FREE BODY COMPOSITION DEVELOPMENT IN AGING
    Richard Boileau; Fiscal Year: 1992
    ..Dual photon absorptiometry has been added to measure total body bone mineral...
  52. Multi-Functional Guidewire for Peripheral Vasculature
    Ghassan S Kassab; Fiscal Year: 2013
    ..Successful completion of the proposed Aims will allow us to translate our research findings into a device that could drastically improve the treatment of PAD. ..
  53. Label-free multichannel spectral cytometry based on stimulated Raman scattering
    Ji Xin Cheng; Fiscal Year: 2013
    ..Performance of the label-free spectral cytometer will be tested through quantitation of fat storage in adipocytes and of drug uptake by cancer cells. ..
  54. TRANSEPITHELIAL MIGRATION OF HUMAN NEUTROPHILS
    Eva Cramer; Fiscal Year: 1991
    ..The results of these studies should provide insight into how leukocytes are attracted to and recognize influenza-infected epithelia and the role they play in limiting viral spread and initiating recovery...
  55. ADAPTIVE ELECTRIC CURRENT COMPUTED TOMOGRAPHY SYSTEM
    JONATHAN NEWELL; Fiscal Year: 1990
    ..Full advantage of this flexibility is achieved by the use of the adaptive current algorithm which selects the optimal current pattern to apply based upon the observed unknown conductivities...
  56. KIDNEY ISCHEMIA AND TIGHT JUNCTION RECOVERY
    Sanjay Nigam; Fiscal Year: 2001
    ..He will then determine total vs. radiolabeled tight junction protein in immunoprecipitates from macromolecular complex, the extractable fraction, and in the cell-surface pool. ..
  57. Micro-Fabricated Complete Blood Counter
    HAROLD AYLIFFE; Fiscal Year: 2007
    ..blood analysis that utilizes micro-electro- mechanical systems (MEMS) fabricated chips and radio-frequency electric impedance (EI) interrogation signals to differentiate blood cell types...
  58. Creation of an In Vitro Brain Barrier Transport System
    Wei Zheng; Fiscal Year: 2006
    ....
  59. ELECTRICAL IMPEDANCE TOMOGRAPHY IMAGED CRYOSURGERY
    Boris Rubinsky; Fiscal Year: 2003
    ..Completion of the project will establish EIT as effective for imaging minimally invasive surgical procedures in general and cryosurgery, in particular. ..
  60. ICU ARF DIALYSIS DOSE QUANTIFICATION AND PATIENT OUTCOME
    Emil Paganini; Fiscal Year: 2001
    ..It is expected that this project, along with the other IRPG generated data, will provide the building blocks for the design and implementation of future multi-centered interventional trials in Acute Renal Failure.] ..
  61. Analysis of Nitric Oxide During Meridian Practices
    Sheng Xing Ma; Fiscal Year: 2007
    ..abstract_text> ..
  62. Effects of HIV Protease Inhibitors of Endothelial Barrie
    Changyi Chen; Fiscal Year: 2005
    ..Our findings may also suggest new therapeutic strategies, which may eventually prove effective for the prevention and treatment of these complications. ..
  63. High Performance Ultrasound Devise for Medical Imaging
    HAIXING ZHENG; Fiscal Year: 2007
    ..For device design, it is difficult to match both acoustic impedance and electric impedance and other requirement...
  64. An Electrical Impedance Monitor
    Justin Clark; Fiscal Year: 2004
    ..The tasks of Phase I are directed toward the development and validation of the method. Assuming a successful Phase I, a commercial prototype instrument will be designed and tested in the Phase II. ..
  65. Cryosurgery with Electrical Impedance Tomography
    Alexander Hartov; Fiscal Year: 2001
    ..The integration of EIT capabilities with their existing equipment would constitutive a unique and possible very significant improvement in the current state of the art in cryosurgery. ..
  66. DEVELOPMENT AND MAINTENANCE OF EPITHELIAL CELL POLARITY
    PHILIP BREITFELD; Fiscal Year: 1990
    ..Thus, this system will allow for the direct examination of several aspects of cell polarity which will aid in understanding normal morphogenesis, embryogenesis, and fetal development...