sonication

Summary

Top Publications

  1. ncbi Sonication of removed hip and knee prostheses for diagnosis of infection
    Andrej Trampuz
    Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    N Engl J Med 357:654-63. 2007
  2. ncbi Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique
    Richard C Murdock
    Applied Biotechnology Branch, Human Effectiveness Directorate Air Force Research Laboratory HEPB, Wright Patterson Air Force Board, Ohio 45433, USA
    Toxicol Sci 101:239-53. 2008
  3. ncbi Sonication cultures of explanted components as an add-on test to routinely conducted microbiological diagnostics improve pathogen detection
    Johannes Holinka
    Department of Orthopaedic Surgery, Medical University of Vienna, General Hospital, Vienna, Austria
    J Orthop Res 29:617-22. 2011
  4. pmc Prosthetic joint infection diagnosis using broad-range PCR of biofilms dislodged from knee and hip arthroplasty surfaces using sonication
    Eric Gomez
    Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    J Clin Microbiol 50:3501-8. 2012
  5. ncbi Reversible blood-brain barrier disruption by repeated transcranial focused ultrasound allows enhanced extravasation
    Feng Yi Yang
    Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang Ming University, Taipei, Taiwan
    J Control Release 150:111-6. 2011
  6. pmc Improved diagnosis of periprosthetic joint infection by multiplex PCR of sonication fluid from removed implants
    Yvonne Achermann
    Infectious Diseases Service, Department of Internal Medicine, Cantonal Hospital Zug, Baar, Switzerland
    J Clin Microbiol 48:1208-14. 2010
  7. pmc Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium
    Nickolai Sheikov
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Ultrasound Med Biol 34:1093-104. 2008
  8. ncbi Micro-SPECT/CT-based pharmacokinetic analysis of 99mTc-diethylenetriaminepentaacetic acid in rats with blood-brain barrier disruption induced by focused ultrasound
    Feng Yi Yang
    Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan
    J Nucl Med 52:478-84. 2011
  9. pmc Treating glioblastoma multiforme with selective high-dose liposomal doxorubicin chemotherapy induced by repeated focused ultrasound
    Feng Yi Yang
    Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang Ming University, Taipei Taiwan fyyang ym edu tw
    Int J Nanomedicine 7:965-74. 2012
  10. pmc Escherichia coli variants in periprosthetic joint infection: diagnostic challenges with sessile bacteria and sonication
    Parham Sendi
    Unit of Infectious Diseases, Basel University Medical Clinic Liestal, and Clinic of Orthopedic Surgery, Cantonal Hospital, Rheinstrasse 26, 4410 Liestal, Switzerland
    J Clin Microbiol 48:1720-5. 2010

Detail Information

Publications273 found, 100 shown here

  1. ncbi Sonication of removed hip and knee prostheses for diagnosis of infection
    Andrej Trampuz
    Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    N Engl J Med 357:654-63. 2007
    ..We hypothesized that culturing of samples obtained from the prosthesis would improve the microbiologic diagnosis of prosthetic-joint infection...
  2. ncbi Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique
    Richard C Murdock
    Applied Biotechnology Branch, Human Effectiveness Directorate Air Force Research Laboratory HEPB, Wright Patterson Air Force Board, Ohio 45433, USA
    Toxicol Sci 101:239-53. 2008
    ..It was also necessary to characterize the impact of sonication, which is implemented to aid in particle dispersion and solution mixture...
  3. ncbi Sonication cultures of explanted components as an add-on test to routinely conducted microbiological diagnostics improve pathogen detection
    Johannes Holinka
    Department of Orthopaedic Surgery, Medical University of Vienna, General Hospital, Vienna, Austria
    J Orthop Res 29:617-22. 2011
    ..improve the pathogen detection in prosthetic joint infections, particularly to evaluate the feasibility of the sonication culture method in the clinical routine...
  4. pmc Prosthetic joint infection diagnosis using broad-range PCR of biofilms dislodged from knee and hip arthroplasty surfaces using sonication
    Eric Gomez
    Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    J Clin Microbiol 50:3501-8. 2012
    ..the utility of PCR on biofilms dislodged from the surface of explanted arthroplasties using vortexing and sonication (i.e., sonicate fluid PCR)...
  5. ncbi Reversible blood-brain barrier disruption by repeated transcranial focused ultrasound allows enhanced extravasation
    Feng Yi Yang
    Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang Ming University, Taipei, Taiwan
    J Control Release 150:111-6. 2011
    ..we demonstrate that, using this noninvasive treatment, Evans Blue (EB) extravasation can be enhanced by repeated sonication. Sonications were applied at an ultrasound frequency of 1 MHz with a 5% duty cycle, and a repetition frequency ..
  6. pmc Improved diagnosis of periprosthetic joint infection by multiplex PCR of sonication fluid from removed implants
    Yvonne Achermann
    Infectious Diseases Service, Department of Internal Medicine, Cantonal Hospital Zug, Baar, Switzerland
    J Clin Microbiol 48:1208-14. 2010
    ..We evaluated the value of multiplex PCR for detection of microbial DNA in sonication fluid from removed orthopedic prostheses...
  7. pmc Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium
    Nickolai Sheikov
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Ultrasound Med Biol 34:1093-104. 2008
    ..proteins occludin, claudin-1, claudin-5, and of submembranous ZO-1 were examined at 1, 2, 4, 6 and 24 h after sonication. A quantitative evaluation of the protein expression was made by counting the number of immunosignals per ..
  8. ncbi Micro-SPECT/CT-based pharmacokinetic analysis of 99mTc-diethylenetriaminepentaacetic acid in rats with blood-brain barrier disruption induced by focused ultrasound
    Feng Yi Yang
    Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan
    J Nucl Med 52:478-84. 2011
    ..The pharmacokinetics of the healthy and tumor-containing brains after BBB-D were compared to identify the optimal time period for combined treatment...
  9. pmc Treating glioblastoma multiforme with selective high-dose liposomal doxorubicin chemotherapy induced by repeated focused ultrasound
    Feng Yi Yang
    Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang Ming University, Taipei Taiwan fyyang ym edu tw
    Int J Nanomedicine 7:965-74. 2012
    ..The present study shows that repeated pulsed high-intensity focused ultrasound (HIFU) can be used to deliver high-dose atherosclerotic plaque-specific peptide-1 (AP-1)-conjugated liposomes selectively to brain tumors...
  10. pmc Escherichia coli variants in periprosthetic joint infection: diagnostic challenges with sessile bacteria and sonication
    Parham Sendi
    Unit of Infectious Diseases, Basel University Medical Clinic Liestal, and Clinic of Orthopedic Surgery, Cantonal Hospital, Rheinstrasse 26, 4410 Liestal, Switzerland
    J Clin Microbiol 48:1720-5. 2010
    ..With sonication, adherent bacteria can be dislodged from the prosthesis...
  11. ncbi Sonication of removed breast implants for improved detection of subclinical infection
    U M Rieger
    Department of Plastic, Reconstructive, and Aesthetic Surgery, University Hospital of Basel, Spitalstrasse 21, 4031, Basel, Switzerland
    Aesthetic Plast Surg 33:404-8. 2009
    ..Current diagnostic tests consist of intraoperative swabs and tissue biopsies. Sonication of removed implants may improve the diagnosis of implant infection by detachment of biofilms from the implant ..
  12. ncbi Targeted disruption of the blood-brain barrier with focused ultrasound: association with cavitation activity
    N McDannold
    Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Phys Med Biol 51:793-807. 2006
    ..40 and 0.57 MPa. BBBD was observed in contrast MRI after sonication at 0.29-0.57 MPa...
  13. ncbi Multiplex PCR of sonication fluid accurately differentiates between prosthetic joint infection and aseptic failure
    María Eugenia Portillo
    Microbiology Laboratory, Reference Laboratory of Catalunya, Carrer de la Selva, 10, Edifici Inblau A Parc de Negocis MasBlau I, El Prat de Llobregat, 08820 Barcelona, Spain
    J Infect 65:541-8. 2012
    ..Cultures have limited sensitivity in the diagnosis of prosthetic joint infection (PJI), especially in low-grade infections. We assessed the value of multiplex PCR in differentiating PJI from aseptic failure (AF)...
  14. pmc Sonication versus vortexing of implants for diagnosis of prosthetic joint infection
    María Eugenia Portillo
    Microbiology Laboratory, Reference Laboratory of Catalunya, Barcelona, Spain
    J Clin Microbiol 51:591-4. 2013
    Biofilm removal efficacy of vortexing alone was compared with the standard vortexing-sonication procedure. Among 135 removed prostheses, 35 were diagnosed with infection and 100 with aseptic failure...
  15. ncbi High-efficiency Agrobacterium-mediated transformation of citrus via sonication and vacuum infiltration
    Maria Luiza Peixoto de Oliveira
    Plant Biology Department, Plant Tissue Culture Laboratory BIOAGRO, Federal University of Vicosa, Vicosa, MG, Brazil
    Plant Cell Rep 28:387-95. 2009
    ..X Poncirus trifoliata (L.) Raf.] was developed in order to increase transformation frequency. Sonication-assisted Agrobacterium-mediated transformation (SAAT), vacuum infiltration, and a combination of the two ..
  16. ncbi Therapeutic arteriogenesis by ultrasound-mediated VEGF165 plasmid gene delivery to chronically ischemic skeletal muscle
    Howard Leong-Poi
    Division of Cardiology, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Circ Res 101:295-303. 2007
    ..The results of our study demonstrate the utility of ultrasonic destruction of plasmid-bearing microbubbles to induce therapeutic arteriogenesis in the setting of severe chronic ischemia...
  17. pmc Microbiologic diagnosis of prosthetic shoulder infection by use of implant sonication
    Kerryl E Piper
    Division of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, 200 First St S W, Rochester, MN 55905, USA
    J Clin Microbiol 47:1878-84. 2009
    We recently described a sonication technique for the diagnosis of prosthetic knee and hip infections...
  18. pmc Influence of the cell wall on intracellular delivery to algal cells by electroporation and sonication
    Harold R Azencott
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA
    Ultrasound Med Biol 33:1805-17. 2007
    ..Chlamydomonas reinhardtii algal cells and mutant cells lacking a cell wall were exposed to electroporation or sonication. Flow cytometry determined intracellular uptake of calcein and bovine serum albumin (BSA) and loss of cell ..
  19. ncbi High throughput sonication: evaluation for compound solubilization
    Kevin Oldenburg
    MatriCal, Inc, Spokane, WA, USA
    Comb Chem High Throughput Screen 8:499-512. 2005
    ..here that efficient compound dissolution is possible even in 384 well format by the use of in-well plate-based sonication. Surprisingly, compounds precipitated from DMSO stocks either by water uptake or repeated freeze thaw cycles can ..
  20. ncbi Bacterial biofilms and capsular contracture in patients with breast implants
    U M Rieger
    Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University, Innsbruck, Austria
    Br J Surg 100:768-74. 2013
    ..It has been hypothesized that bacterial biofilms on breast implants may cause chronic inflammation leading to capsular contracture. The association between bacterial biofilms of removed implants and capsular contracture was investigated...
  21. pmc Sonication is superior to scraping for retrieval of bacteria in biofilm on titanium and steel surfaces in vitro
    Geir Bjerkan
    Department of Orthopaedic Surgery, St Olav s University Hospital, Trondheim, Norway
    Acta Orthop 80:245-50. 2009
    ..Consequently, detachment of the causative adherent bacteria is crucial for correct microbiological diagnosis. Using an in vitro model, we compared 4 methods of biofilm sampling from metal surfaces...
  22. ncbi Correlations to predict droplet size in ultrasonic atomisation
    R Rajan
    Hindustan Lever Research Centre, Whitefield, Bangalore, India
    Ultrasonics 39:235-55. 2001
    ..Also, an empirical correlation from experimental data has been proposed in this work...
  23. ncbi Quantitative evaluation of focused ultrasound with a contrast agent on blood-brain barrier disruption
    Feng Yi Yang
    Institute of Biomedical Engineering, College of Medicine, National Taiwan University, Taipei, Taiwan
    Ultrasound Med Biol 33:1421-7. 2007
    The use of an ultrasound contrast agent (UCA) with focused ultrasound sonication has the potential to disrupt the blood-brain barrier (BBB) noninvasively and reversibly at target locations...
  24. pmc PCR-hybridization after sonication improves diagnosis of implant-related infection
    Jaime Esteban
    Department of Clinical Microbiology, IIS Fundación Jiménez Díaz, Madrid, Spain
    Acta Orthop 83:299-304. 2012
    We wanted to improve the diagnosis of implant-related infection using molecular biological techniques after sonication.
  25. ncbi Delivery of liposomal doxorubicin (Doxil) in a breast cancer tumor model: investigation of potential enhancement by pulsed-high intensity focused ultrasound exposure
    Victor Frenkel
    Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Building 10, Room 1N306a, 10 Center Drive, Bethesda, MD 20892, USA
    Acad Radiol 13:469-79. 2006
    ..To investigate the potential of using pulsed high-intensity focused ultrasound (HIFU) exposures to enhance the delivery, and hence therapeutic effect of liposomal doxorubicin (Doxil) in a murine breast cancer tumor model...
  26. ncbi Ultrasonography-based 2D motion-compensated HIFU sonication integrated with reference-free MR temperature monitoring: a feasibility study ex vivo
    Vincent Auboiroux
    Faculty of Medicine, University of Geneva, Switzerland
    Phys Med Biol 57:N159-71. 2012
    ..The effective duty-cycle of the HIFU sonication was close to 100 % and no off-interval was required to temporally decouple it from the ultrasonography...
  27. ncbi The rapid determination of sideroxylonals in Eucalyptus foliage by extraction with sonication followed by HPLC
    Ian R Wallis
    School of Botany and Zoology, Australian National University Canberra 0200, Australia
    Phytochem Anal 16:49-54. 2005
    ..Samples of dry, ground foliage were extracted by sonication with 20% methanol in acetonitrile, 7% water in acetonitrile or 40% water in acetonitrile and the extracts ..
  28. pmc Modulation of intracellular Ca2+ concentration in brain microvascular endothelial cells in vitro by acoustic cavitation
    Juyoung Park
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2099, USA
    Ultrasound Med Biol 36:1176-87. 2010
    ....
  29. ncbi Ultrasound triggered drug release from 10-hydroxycamptothecin-loaded phospholipid microbubbles for targeted tumor therapy in mice
    Pan Li
    The Second Affiliated Hospital of Chongqing Medical University, PR China
    J Control Release 162:349-54. 2012
    ..6%) compared with HLMs alone (47.8%) as well as commercial HCPT injection (49.4). In conclusion, HLMs are expected to improve the therapeutic efficacy of MBs and are worthy of further study for UTMD mediated drug delivery...
  30. pmc The use of injectable sonication-induced silk hydrogel for VEGF(165) and BMP-2 delivery for elevation of the maxillary sinus floor
    Wenjie Zhang
    Department of Prosthodontics, Ninth People s Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China
    Biomaterials 32:9415-24. 2011
    b>Sonication-induced silk hydrogels were previously prepared as an injectable bone replacement biomaterial, with a need to improve osteogenic features...
  31. ncbi An ultrastrong nanofibrillar biomaterial: the strength of single cellulose nanofibrils revealed via sonication-induced fragmentation
    Tsuguyuki Saito
    Department of Biomaterials Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Biomacromolecules 14:248-53. 2013
    ..The strength of individual nanofibrils was estimated based on a model for the sonication-induced fragmentation of filamentous nanostructures...
  32. pmc A new strategy to enhance cavitational tissue erosion using a high-intensity, Initiating sequence
    Zhen Xu
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 53:1412-24. 2006
    ..The high-intensity, initiating sequence enhances cavitational tissue erosion and enables erosion at intensities significantly lower than what is required to initiate erosion...
  33. ncbi Microbial diversity in biofilm infections of the urinary tract with the use of sonication techniques
    Veronika Hola
    Microbiological Institute, Faculty of Medicine, Masaryk University and St Anne s University Hospital, Czech Republic
    FEMS Immunol Med Microbiol 59:525-8. 2010
    ....
  34. ncbi Wrapping bacteria by graphene nanosheets for isolation from environment, reactivation by sonication, and inactivation by near-infrared irradiation
    O Akhavan
    Department of Physics, Sharif University of Technology, P O Box 11155 9161, Tehran, Iran
    J Phys Chem B 115:6279-88. 2011
    ..However, after removing the sheets from the surface of the microorganisms by using sonication, they could again interact with their environment...
  35. ncbi Quick synthesis of lipid-polymer hybrid nanoparticles with low polydispersity using a single-step sonication method
    Ronnie H Fang
    Department of Nanoengineering and Moores Cancer Center, University of California San Diego, La Jolla, California 92093, United States
    Langmuir 26:16958-62. 2010
    ..Using a bath sonication approach, we demonstrate that the whole hybrid nanoparticle synthesis process can be completed in about 5 min ..
  36. pmc Sonoporation enhances chemotherapeutic efficacy in retinoblastoma cells in vitro
    Nahyoung G Lee
    Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Invest Ophthalmol Vis Sci 52:3868-73. 2011
    ..To study the ability of ultrasound (US) and microbubbles (MB) to enhance chemotherapeutic efficacy against retinoblastoma Y79 cells in vitro...
  37. ncbi Tunable gel formation by both sonication and thermal processing in a cholesterol-based self-assembly system
    Junchen Wu
    Department of Chemistry and Laboratory of Advanced Materials, Fudan University, 220 Handan Road, Shanghai 200433, China
    Chemistry 15:6234-43. 2009
    ..reveal that the cooperation and relative competition of multiple intermolecular interactions, influenced by the sonication or thermal stimulus, are the main contributors for the aggregation or nucleation processes; this results in the ..
  38. pmc Examination of inertial cavitation of Optison in producing sonoporation of chinese hamster ovary cells
    Monica M Forbes
    Department of Bioengineering, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Ultrasound Med Biol 34:2009-18. 2008
    ....
  39. ncbi Effects of microbubbles on ultrasound-mediated gene transfer in human prostate cancer PC3 cells: comparison among Levovist, YM454, and MRX-815H
    Akihiko Watanabe
    Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Cancer Lett 265:107-12. 2008
    ..higher than those without shell (Levovist), and the order of the ECAs facilitating free radical formation by sonication was; YM454>MRX-815H>Levovist...
  40. ncbi Ultrasound microbubbles enhance recombinant adeno-associated virus vector delivery to retinal ganglion cells in vivo
    Wenyue Xie
    Department of Ophthalmology, Second Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing 400010, China
    Acad Radiol 17:1242-8. 2010
    ....
  41. pmc Sonication of proteins causes formation of aggregates that resemble amyloid
    Peter B Stathopulos
    Guelph Waterloo Centre for Graduate Studies in Chemistry and Biochemistry, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    Protein Sci 13:3017-27. 2004
    Despite the widespread use of sonication in medicine, industry, and research, the effects of sonication on proteins remain poorly characterized...
  42. ncbi Breaking down the wall: fractionation of mycobacteria
    Mandana Rezwan
    Institut fur Medizinische Mikrobiologie, Gloriastrasse 32, Universität Zürich CH 8006 Zürich, Switzerland
    J Microbiol Methods 68:32-9. 2007
    ..of high pressure (cell disrupter/French press) with those of pathogen-compatible breakage methods such as sonication, bead beater and lysozyme treatment using the non-pathogenic Mycobacterium smegmatis...
  43. ncbi Vascular gene transfer of phosphomimetic endothelial nitric oxide synthase (S1177D) using ultrasound-enhanced destruction of plasmid-loaded microbubbles improves vasoreactivity
    Claudius Teupe
    Molecular Cardiology, Department of Medicine IV, Institut für Kardiovaskuläre Physiologie, University of Frankfurt, Germany
    Circulation 105:1104-9. 2002
    ..For gene transfer, we used a phosphomimetic, active endothelial nitric oxide synthase (eNOS) construct in which Ser1177 was replaced by aspartic acid (S1177D) and exhibits a 2-fold higher basal activity than the wild-type enzyme...
  44. pmc Sonoporation from jetting cavitation bubbles
    Claus Dieter Ohl
    Faculty of Science and Technology, Physics of Fluids, University of Twente, Enschede, The Netherlands
    Biophys J 91:4285-95. 2006
    ..Apart from annular sites of sonoporation we also find more homogenous patterns of molecule delivery with no cell detachment...
  45. ncbi Acoustically active lipospheres containing paclitaxel: a new therapeutic ultrasound contrast agent
    E C Unger
    ImaRx Pharmaceutical Corp, Tucson, AZ 85719, USA
    Invest Radiol 33:886-92. 1998
    ..Paclitaxel-carrying lipospheres (MRX-552) were developed and evaluated as a new ultrasound contrast agent for chemotherapeutic drug delivery...
  46. ncbi Ultrasound exposure of lipoplex loaded microbubbles facilitates direct cytoplasmic entry of the lipoplexes
    Ine Lentacker
    Laboratory of General Biochemistry and Physical Pharmacy, Ghent Research Group on Nanomedicine, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    Mol Pharm 6:457-67. 2009
    ..This is attractive as the in vivo use of PEGylated nanoparticles remains currently limited due to a decreased cellular uptake and inefficient escape of the PEGylated nanoparticles from the endosomes...
  47. ncbi Cavitation-enhanced extravasation for drug delivery
    Costas D Arvanitis
    Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Headington, Oxford, UK
    Ultrasound Med Biol 37:1838-52. 2011
    ....
  48. ncbi Advanced Fenton processing of aqueous phenol solutions: a continuous system study including sonication effects
    K C Namkung
    Hub University for Industrial Collaboration, Seoul National University of Technology, 172 Gongneung 2 dong, Nowon, Seoul 139 743, South Korea
    Ultrason Sonochem 15:171-6. 2008
    ..b>Sonication with a bath type sonicator resulted in relatively small enhancements of TOC removal but further studies with cup-..
  49. pmc Ultrasound-mediated release of hydrophilic and lipophilic agents from echogenic liposomes
    Jonathan A Kopechek
    Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45267 0586 USA
    J Ultrasound Med 27:1597-606. 2008
    ....
  50. ncbi Improved Agrobacterium-mediated transformation of cowpea via sonication and vacuum infiltration
    Souvika Bakshi
    Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India
    Plant Cell Rep 30:2281-92. 2011
    An improved method of Agrobacterium-mediated transformation of cowpea was developed employing both sonication and vacuum infiltration treatments...
  51. pmc Saving cells from ultrasound-induced apoptosis: quantification of cell death and uptake following sonication and effects of targeted calcium chelation
    J D Hutcheson
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Ultrasound Med Biol 36:1008-21. 2010
    ..of ultrasound for noninvasive drug and gene delivery have been limited by associated cell death as a result of sonication. In this study, we sought to quantify the distribution of cellular bioeffects caused by low-frequency ultrasound ..
  52. ncbi Bacterial colonization and infection of electrophysiological cardiac devices detected with sonication and swab culture
    Martin Rohacek
    Department of Internal Medicine, Luzerner Kantonsspital, Luzern
    Circulation 121:1691-7. 2010
    Electrophysiological cardiac devices are increasingly used. The frequency of subclinical infection is unknown. We investigated all explanted devices using sonication, a method for detection of microbial biofilms on foreign bodies.
  53. pmc In vitro effect of ultrasound on bacteria and suggested protocol for sonication and diagnosis of prosthetic infections
    Tor Monsen
    Department of Clinical Bacteriology, University Hospital of Umea, Sweden
    J Clin Microbiol 47:2496-501. 2009
    b>Sonication of implants has been shown to be a promising method for diagnosis of prosthetic infections due to its improved sensitivity, simplicity, and low cost...
  54. pmc Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Ultrasound Med Biol 34:834-40. 2008
    ..It also suggests that lower frequency sonication produces less red blood cell extravasation per unit area.
  55. pmc Changes in cell morphology due to plasma membrane wounding by acoustic cavitation
    Robyn K Schlicher
    The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Atlanta, GA, USA
    Ultrasound Med Biol 36:677-92. 2010
    ....
  56. ncbi Factors affecting production of transgenic rats by ICSI-mediated DNA transfer: effects of sonication and freeze-thawing of spermatozoa, rat strains for sperm and oocyte donors, and different constructs of exogenous DNA
    Masumi Hirabayashi
    Center for Brain Experiment, National Institute for Physiological Sciences, Okazaki, Aichi, Japan
    Mol Reprod Dev 70:422-8. 2005
    ..One plasmid DNA (Fyn, 5.0 kb) and two BAC DNA (BAC/Fyn, 208 kb; Svet1/IRES-Cre, 186 kb) were successfully introduced into the SD rat genomes via ICSI, with the producing efficiencies of 2.8%, 0.9%, and 2.4%, respectively...
  57. ncbi Effect of ultrasound parameters on the release of liposomal calcein
    Mercy Afadzi
    Department of Physics, The Norwegian University of Science and Technology, Trondheim, Norway
    Ultrasound Med Biol 38:476-86. 2012
    ..The drug's release is probably due to mechanical (cavitation) rather than thermal effects, and that was also confirmed by the detection of hydroxide radicals...
  58. ncbi Relationship between the degree of osteolysis and cultures obtained by sonication of the prostheses in patients with aseptic loosening of a hip or knee arthroplasty
    Josep M Sierra
    Department of Microbiology, Hospital Clinic of Barcelona, Barcelona, Spain
    Arch Orthop Trauma Surg 131:1357-61. 2011
    ..The aim of our study was to sonicate components of joint prostheses removed due to aseptic loosening, culture the sonicate fluid, and to correlate these results with the degree of radiological osteolysis...
  59. ncbi Effect of sonication parameters on transdermal delivery of insulin to hairless rats
    Alain Boucaud
    GIP Ultrasons, Faculty of Medicine, 2 bis Boulevard Tonnelle, BP 3223, 37032 Cedex, Tours, France
    J Control Release 81:113-9. 2002
    ..modification in blood glucose level, indicating that transdermal transport of insulin mainly occurred during sonication. Sonophoresis may therefore potentially be applied for non-invasive and painless delivery of insulin in the ..
  60. ncbi Activity of asynchronous flight muscle from two bee families during sonication (buzzing)
    M J King
    Industrial Research Ltd, Christchurch, New Zealand
    J Exp Biol 199:2317-21. 1996
    The indirect flight muscles of bees are used to produce a variety of actions in addition to flight, including sonication, which has a higher frequency than flight...
  61. ncbi Effect of ultrasound treatment on steady and dynamic shear properties of glucomannan based salep dispersions: optimization of amplitude level, sonication time and temperature using response surface methodology
    Safa Karaman
    Erciyes University, Engineering Faculty, Food Engineering Department, 38039 Kayseri, Turkey
    Ultrason Sonochem 19:928-38. 2012
    The present study investigated effect of different amplitude levels (40, 70 and 100%), sonication temperatures (40, 50 and 60°C) and exposure times (3, 7 and 11 min) on steady shear properties; apparent viscosity (η), shear stress (σ), ..
  62. ncbi Experimental investigation of MRgHIFU sonication with interleaved electronic and mechanical displacement of the focal point for transrectal prostate application
    Lorena Petrusca
    INSERM, U556, Lyon F 69003, France
    Phys Med Biol 57:4805-25. 2012
    ..interest of dual-modality (electronic and mechanical) interleaved displacement of the focus for volumetric sonication paradigms...
  63. ncbi Evaluation of rheological properties and swelling behaviour of sonicated scleroglucan samples
    Siddique Akber Ansari
    Department of Drug Chemistry and Technologies, University La Sapienza, 00185 Rome, Italy
    Molecules 17:2283-97. 2012
    ..was sonicated at two different polymer concentrations for different periods of time and the effect of sonication was investigated with respect to molecular weight variations and rheological properties...
  64. ncbi Using acoustic cavitation to enhance chemotherapy of DOX liposomes: experiment in vitro and in vivo
    Ying Zheng Zhao
    Wenzhou Medical College, Wenzhou City, Zhejiang Province, China
    Drug Dev Ind Pharm 38:1090-8. 2012
    ..Acoustic cavitation could enhance the absorption efficiency of DOX liposomes, which could be used to reduce DOX adverse effect on normal organs in clinical chemotherapy...
  65. ncbi Glycine catalyzed convenient synthesis of 2-amino-4H-chromenes in aqueous medium under sonic condition
    Bandita Datta
    Department of Studies in Chemistry, Bangalore University, Central College Campus, Palace Road, Bengaluru 560001, India
    Ultrason Sonochem 19:725-8. 2012
    ..This protocol afforded corresponding 2-amino-4H-chromenes in shorter reaction times, high yields and simple work-up procedures with the green aspects by avoiding toxic reagents...
  66. ncbi The relationship between microbiology results in the second of a two-stage exchange procedure using cement spacers and the outcome after revision total joint replacement for infection: the use of sonication to aid bacteriological analysis
    L Sorli
    Parc de Salut Mar, Service of Internal Medicine and Infectious Diseases, Passeig Maritim 25 29, Passeig Maritim 25 29, E 08003 Barcelona, Spain
    J Bone Joint Surg Br 94:249-53. 2012
    ..In this study it was hypothesised that subclinical infection may be diagnosed with sonication of the surface biofilm of the spacer...
  67. pmc Sonication of explanted cardiac implants improves microbial detection in cardiac device infections
    Alessandra Oliva
    Dipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università, Rome, Italy
    J Clin Microbiol 51:496-502. 2013
    The sonication technique has been shown to be a promising tool for microbiological diagnosis of device-related infections...
  68. ncbi Proteases and sonication specifically remove the exosporium layer of spores of Clostridium difficile strain 630
    Karina Escobar-Cortés
    Laboratorio de Mecanismos de Patogénesis Bacteriana, Departamento de Ciencias Biologicas, Universidad Andres Bello, Santiago, Chile
    J Microbiol Methods 93:25-31. 2013
    ..difficile spores through either protease digestion or sonication treatment leaving the spore coat structure intact...
  69. ncbi Cytotoxicity of multi-walled carbon nanotubes in three skin cellular models: effects of sonication, dispersive agents and corneous layer of reconstructed epidermis
    Sebastien Vankoningsloo
    Laboratory of Cellular Biochemistry and Biology, University of Namur, Namur, Belgium
    Nanotoxicology 4:84-97. 2010
    ..as micrometric agglomerates, were not harmful to skin cells, except minor effects in keratinocytes, (ii) mild sonication slightly decreased nanotube agglomeration but increased cytotoxicity on keratinocytes, (iii) addition of ..
  70. pmc Focused-ultrasound disruption of the blood-brain barrier using closely-timed short pulses: influence of sonication parameters and injection rate
    Meaghan A O'Reilly
    Imaging Research, Sunnybrook Research Institute, Toronto, Ontario, Canada
    Ultrasound Med Biol 37:587-94. 2011
    ..Increased burst PRF combined with infusion improved T1w enhancement but without statistical significance, whereas a decrease in burst PRF showed a statistically significant decrease in enhancement...
  71. ncbi Sonication parameters for the preparation of biodegradable nanocapsules of controlled size by the double emulsion method
    Ugo Bilati
    School of Pharmacy, University of Geneva, Geneva, Switzerland
    Pharm Dev Technol 8:1-9. 2003
    The main goal of the present work was to study the influence of the sonication process on the characteristics of poly(lactide-co-glycolide) nanocapsules prepared by the water-in-oil-in-water solvent evaporation method...
  72. ncbi Evaluation of a focused sonication probe for arsenic speciation in environmental and biological samples
    E Sanz
    Facultad de Ciencias Quimicas, Universidad Complutense de Madrid UCM, Ciudad Universitaria s n, 28040 Madrid, Spain
    J Chromatogr A 1097:1-8. 2005
    ..The proposed methods were validated by analysing several Certified Reference Materials: SRM 1,568 a rice flour, CRM-627 tuna fish tissue, SOIL-7 soil and MURST-ISS-A1 Antarctic sediment...
  73. ncbi Aggregation of amyloid Abeta((1-40)) peptide in perdeuterated 2,2,2-trifluoroethanol caused by ultrasound sonication
    Andrei V Filippov
    Division of Chemical Engineering, Lulea University of Technology, Luleå SE 97187, Sweden
    Magn Reson Chem 48:427-34. 2010
    Ultrasound sonication of protein and peptide solutions is routinely used in biochemical, biophysical, pharmaceutical and medical sciences to facilitate and accelerate dissolution of macromolecules in both aqueous and organic solvents...
  74. ncbi Advances in sonoporation strategies for cancer
    Olga Zolochevska
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Front Biosci (Schol Ed) 4:988-1006. 2012
    ..Using high-performance probes, more precise and safer sonoporation treatments will be developed, and newer therapeutic prospects will be realized...
  75. ncbi Homogenisation of cystic fibrosis sputum by sonication--an essential step for Aspergillus PCR
    Caroline G Baxter
    The National Aspergillosis Centre, University Hospital of South Manchester, Southmoor Road, Manchester M239LT, UK
    J Microbiol Methods 85:75-81. 2011
    ..This study aimed to optimise sputum homogenisation utilising sonication to improve Aspergillus DNA extraction...
  76. pmc Chromatin immunoprecipitation (ChIP): revisiting the efficacy of sample preparation, sonication, quantification of sheared DNA, and analysis via PCR
    Pamela D Schoppee Bortz
    Cardiovascular Division, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, United States of America
    PLoS ONE 6:e26015. 2011
    ..We demonstrate that high intensity sonication for at least 30 min is required for full cellular disruption and maximum DNA recovery because ChIP lysis buffers ..
  77. ncbi Insonation of the eye in the presence of microbubbles: preliminary study of the duration and degree of vascular bioeffects--work in progress
    Tomihiko Hirokawa
    Department of Medical Biophysics, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Ultrasound Med 26:731-8. 2007
    ..The purpose of this study was to investigate the presence and duration of vascular permeability changes induced by the combination of ultrasound and an intravascular microbubble contrast agent in the rabbit eye...
  78. ncbi Free-flow isoelectric focusing of proteins remaining in cell fragments following sonication of thyroid carcinoma cells
    Christian Obermaier
    FFE Weber GmbH, Martinsried, Germany
    Electrophoresis 26:2109-16. 2005
    ..By sonication, about one-half of the proteins of thyroid cells were released into the supernatant, while the other half ..
  79. pmc Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats
    Shahrzad Jalali
    Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    BMC Neurol 10:114. 2010
    ..Therefore, the aim of this study was to investigate the activation of cell survival signaling molecules in response to ultrasound-mediated BBB opening;..
  80. ncbi Neat DODAB vesicles: Effect of sonication time on the phase transition thermodynamic parameters and its relation with incomplete chain freezing
    R O Brito
    Centro de Investigacao em Quimica, Department of Chemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre 687, P 4169 007 Porto, Portugal
    Chem Phys Lipids 137:18-28. 2005
    ..In this work we present a systematic DSC investigation on the influence of the sonication method on the main temperature and enthalpy of the transition for DODAB vesicles, prepared both in normal and ..
  81. ncbi Harmonic motion imaging for focused ultrasound (HMIFU): a fully integrated technique for sonication and monitoring of thermal ablation in tissues
    C Maleke
    Department of Biomedical Engineering, Columbia University, New York, NY, USA
    Phys Med Biol 53:1773-93. 2008
    ..This paper discusses a method for monitoring thermal treatment at different sonication durations (10 s, 20 s and 30 s) using the amplitude-modulated (AM) harmonic motion imaging for focused ..
  82. ncbi Significance of location of enzymes on their release during microbial cell disruption
    B Balasundaram
    Department of Chemical Engineering University Department of Chemical Technology, Matunga, Mumbai-400 019 India
    Biotechnol Bioeng 75:607-14. 2001
    ..coli during disruption using various techniques has been investigated. The disruption techniques used were sonication, high-pressure homogenization, and hydrodynamic cavitation...
  83. ncbi Hypocholesterolemic effect of sonication-killed Bifidobacterium longum isolated from healthy adult Koreans in high cholesterol fed rats
    Hea Soon Shin
    College of Pharmacy, Duksung Women s University, Seoul, 132 714, Korea
    Arch Pharm Res 33:1425-31. 2010
    ..We here examined the effect of oral administration of sonication-killed B...
  84. ncbi Viability of yeast form cells of Paracoccidioides brasiliensis after sonication
    Maria Fernanda Reis Gavazzoni Dias
    Hospital Universitario Clementino Fraga Filho, Departamento de Dermatologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
    Med Mycol 42:43-9. 2004
    ..In order to obtain free cells, the cultures are usually sonicated. The present study shows that sonication induces lesions in a significant number of cells, as evaluated by labelling of the cells with acridine orange ..
  85. ncbi Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier
    Nickolai Sheikov
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Ultrasound Med Biol 32:1399-409. 2006
    ..present study, we aimed to estimate the rate of the transendothelial vesicular traffic after focused ultrasound sonication in the rabbit brain, using ultrastructural morphometry and horseradish peroxidase (HRP) as a tracer...
  86. pmc Particle size distribution in DMPC vesicles solutions undergoing different sonication times
    Giuseppe Maulucci
    Istituto di Fisica, Universitá Cattolica S Cuore A Gemelli, Rome, Italy
    Biophys J 88:3545-50. 2005
    ..liposome suspensions was investigated by dynamic-light scattering (DLS) as a function of the sonication time (t(s))...
  87. ncbi The effect of sonication on simulated osteoarthritis. Part II: alleviation of osteoarthritis pathogenesis by 1 MHz ultrasound with simultaneous hyaluronate injection
    So Ra Park
    Department of Physiology, College of Medicine, Inha University, Incheon, Korea
    Ultrasound Med Biol 31:1559-66. 2005
    ..In the present study, we evaluated the effectiveness of sonication on the progress of induced OA in rabbits...
  88. ncbi Fast preparation of the seawater accommodated fraction of heavy fuel oil by sonication
    Saioa Elordui-Zapatarietxe
    Institute of Environmental Science and Technology, Universitat Autonoma de Barcelona, Bellaterra 08193, Catalonia, Spain
    Chemosphere 73:1811-6. 2008
    ..Here we describe a simple and fast set up, using sonication, to produce reproducible SWAF in the laboratory...
  89. ncbi The development and evaluation of ultrasound for the treatment of bacterial suspensions. A study of frequency, power and sonication time on cultured Bacillus species
    E Joyce
    Sonochemistry Centre, School of Science and the Environment, Coventry University, CV1 5FB, Coventry, UK
    Ultrason Sonochem 10:315-8. 2003
    ..In assessing the bacterial kill with time under different sonication regimes three types of behaviour were characterized: High power ultrasound (lower frequencies) in low volumes of ..
  90. ncbi Sonochemically fabricated microelectrode arrays for biosensors offering widespread applicability: Part I
    Andrew C Barton
    Institute of BioScience and Technology, Cranfield University at Silsoe, Cranfield Centre for Analytical Science Silsoe, Cranfield, Bedfordshire MK45 4DT, UK
    Biosens Bioelectron 20:328-37. 2004
    ..Sensors already developed for ethanol, oxalate and a number of pesticide determinations will be reported in subsequent publications...
  91. ncbi Improved Agrobacterium-mediated transformation of sunflower (Helianthus annuus L.): assessment of macerating enzymes and sonication
    S Weber
    Institut für Pflanzenbau und Pflanzenzüchtung I, LS Pflanzenzüchtung, Justus Liebig Universitat, Heinrich Buff Ring 26 32, 35392 Giessen, Germany
    Plant Cell Rep 21:475-82. 2003
    ..was evaluated following wounding by cell-wall-digesting enzymes and sonication. The frequency of explants with regenerated shoots expressing GUS (beta-glucuronidase) or GFP (green fluorescent ..
  92. ncbi Evaluation of disruption methods for the release of intracellular recombinant protein from Escherichia coli for analytical purposes
    Jan Tkac
    Division of Biotechnology, Department of Physics and Measurement Technology, Linkoping University, SE 581 83 Linkoping, Sweden
    Biotechnol Appl Biochem 40:83-8. 2004
    ..Three methods of cell disruption, sonication, osmotic shock and chemical treatment using a non-ionic surfactant, were critically compared with respect to ..
  93. ncbi Apoptotic effects of selected strains of lactic acid bacteria on a human T leukemia cell line are associated with bacterial arginine deiminase and/or sphingomyelinase activities
    L Di Marzio
    Department of Experimental Medicine, University of L'Aquila, 67100 L'Aquila, Italy
    Nutr Cancer 40:185-96. 2001
    ..On the other hand, our results indicate that apoptosis induced by CD2 samples could also be associated with high levels of arginine deiminase activity, which in turn was able to downregulate polyamine synthesis in Jurkat cells...
  94. ncbi Brief ultrasonication improves detection of biofilm-formative bacteria around a metal implant
    Naomi Kobayashi
    Department of Anatomic Pathology, The Cleveland Clinic, OH 44195 5138, USA
    Clin Orthop Relat Res 457:210-3. 2007
    ..b>Sonication for 1 minute increased the yield of bacteria...
  95. ncbi Gene therapy progress and prospects: ultrasound for gene transfer
    C M H Newman
    Cardiovascular Research Unit, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    Gene Ther 14:465-75. 2007
    ..Loading MCB with nucleic acids and/or disease-targeting ligands may further improve the efficiency and specificity of UEGT such that clinical testing becomes a realistic prospect...
  96. ncbi Measurement and correlation of acoustic cavitation with cellular bioeffects
    Daniel M Hallow
    School of Chemical and Biomolecular Engineering, Georgia Insitute of Technology, Atlanta, GA 30332 0100, USA
    Ultrasound Med Biol 32:1111-22. 2006
    ..Using broadband noise as a measure of cavitation activity, this study determined the kinetics of cavitation during sonication of Optison contrast agent and tested whether cellular bioeffects can be predicted by cavitation dose...
  97. pmc Evaluation of quantitative analysis of cultures from sonicated retrieved orthopedic implants in diagnosis of orthopedic infection
    Jaime Esteban
    Department of Clinical Microbiology, Fundación Jiménez Díaz UTE, Universidad Autonoma de Madrid, Madrid, Spain
    J Clin Microbiol 46:488-92. 2008
    ..microbiological diagnosis of device-related osteoarticular infections, we have developed a protocol based on the sonication of device samples, followed by concentration and inoculation of the sonicate in a broad variety of media in a ..
  98. ncbi Development of a laboratory model to assess the removal of biofilm from interproximal spaces by powered tooth brushing
    Heather Adams
    Washington State University, Pullman, Washington, USA
    Am J Dent 15:12B-17B. 2002
    ..To develop an interproximal laboratory model to compare the potential effectiveness of powered brushing to remove biofilm plaque from interproximal spaces beyond the reach of bristles...
  99. ncbi Application of sonication to release DNA from Bacillus cereus for quantitative detection by real-time PCR
    Else Marie Fykse
    Norwegian Defence Research Establishment, Division for Protection and Materiel, PO Box 25, N 2027 Kjeller, Norway
    J Microbiol Methods 55:1-10. 2003
    A rapid sonication method for lysis of Gram-positive bacteria was evaluated for use in combination with quantitative real-time polymerase chain reaction (PCR) analyses for detection...
  100. ncbi Comparison of the interproximal plaque removal efficacy of two powered toothbrushes using in vitro oral biofilms
    Christopher K Hope
    Department of Microbiology, Eastman Dental Institute for Oral Healthcare Sciences, University College London, UK
    Am J Dent 15:7B-11B. 2002
    ....
  101. ncbi Extraction of up to 95% of wheat (Triticum aestivum) flour protein using warm sodium dodecyl sulfate (SDS) without reduction or sonication
    Frances M DuPont
    United States Department of Agriculture, Agricultural Research Service, Western Regional Research Center, 800 Buchanan Street, Albany, California 94710, USA
    J Agric Food Chem 56:7431-8. 2008
    Extraction of glutenin polymers without sonication is an essential prerequisite for accurate determination of their composition and molecular size distribution. Sequential fractionation of wheat flour with 0.1 M KCl and 0...

Research Grants64

  1. Cavitation Enhancement of Biospecimen processing for Improved DNA Fragmentation
    WILLIAM PERRY JANZEN; Fiscal Year: 2013
    ..buffer reagents, microbubble size, microbubble concentration, acoustic frequency, acoustic peak pressure, and sonication duration...
  2. A Novel Ultrasound Phased Array and Sonication Method for Stroke Treatments
    Kullervo Hynynen; Fiscal Year: 2012
    ..It is our hypothesis that transcranial sonication using phased array applicators and patient-specific skull information derived from CT scans can better localize ..
  3. ORAL CONTROLLED-RELEASE DELIVERY SYSTEMS
    H Rawls; Fiscal Year: 1991
    ..Microcapsules will be prepared using a published sonication/solvent evaporation method...
  4. Laser-enhanced particle-free HIFU heating
    Xinmai Yang; Fiscal Year: 2013
    ..However, the volume of the lesion following a single HIFU sonication is small. As a result, it can take up to several hours to ablate a relatively small tumor...
  5. ANTI-AIDS NUCLEOSIDE CONJUGATES OF ETHER PHOSPHOLIPIDS
    CHUNG HONG; Fiscal Year: 1992
    ..The conjugates will be formulated as a micellar solution (size 0.01-0.1 mum) by sonication of water suspension of the conjugate. The micellar solution also dissolves the water-insoluble anti-HIV agents...
  6. Organotrifluoroborates in Selective Organic Synthesis
    Gary A Molander; Fiscal Year: 2013
    ..g., water, ionic liquids), the bases required, and the conditions of the reaction (e.g., by using sonication or microwaves)...
  7. Non-invasive Modulation of Brain Function by Focused Ultrasound
    Seung Schik Yoo; Fiscal Year: 2012
    ..We will develop a magnetic resonance imaging (MRI)-guided sonication environment, capable of evaluating local brain function using electrophysiological recordings (..
  8. ACOUSTIC PEDIATRIC OSTEOMETER FOR LONG BONE ASSESSMENT
    Armen Sarvazyan; Fiscal Year: 2000
    ..By discrete sonication along a bone by linear array of probes, the APO will generate an ultrasound velocity profile of the examination ..
  9. Hyperacetylation of Biologically Active SV40 Chromatin
    Barry Milavetz; Fiscal Year: 2006
    ..The SV40 chromatin will be analyzed either as intact chromosomes or following sonication or micrococcal nuclease digestion to generate suitably sized fragments of chromatin by a combination of ..
  10. Passive Cavitation Imaging for Guidance and Control of Ultrasound Ablation
    T Douglas Mast; Fiscal Year: 2010
    ..beams, can be passively imaged by ultrasound arrays, providing specific information about spatially-dependent sonication intensity, temperature, and tissue viability in vivo...
  11. Low-Intensity Ultrasound for Treating Tumor Vasculature
    Andrew Wood; Fiscal Year: 2009
    ..a sensitive ultrasound imaging assay that can be used to quantitatively monitor the antivascular action of sonication. This raises the possibility of using ultrasound to treat cancers by targeting their blood vessels...
  12. A cell-free system for exocytosis in the beta-cell
    SUSANNE STRAUB SHARP; Fiscal Year: 2005
    ..Optimization of the system will be achieved by studying the effects of changes in sonication conditions, e.g...
  13. CELLULAR IMMUNE RESPONSES TO ORAL BACTERIAL ANTIGENS
    PRISCILLA CHEN; Fiscal Year: 1980
    ..Cell walls of A. Viscosus are obtained after sonication. Soluble antigens and cell walls of B. asaccharolyticus are also being prepared...
  14. ULTRASONIC RADIATION OF NUCLEIC ACIDS AND COMPONENTS
    SHIH WANG; Fiscal Year: 1980
    ..1) the study of the sonochemical changes of nucleic acid bases, nucleosides, and nucleotides at low levels of sonication (less than or equal to 5 W per sq. cm, less than 30 min, 1 MHz) and 2) the examination of the inactivation of H...
  15. Phased Array Ultrasound System for Cardiac Ablation
    Kullervo Hynynen; Fiscal Year: 2006
    ..To accomplish this we plan to: First, perform in vivo animal tests with our linear phased arrays to explore the sonication parameters and methods for inducing adequate tissue coagulation...
  16. Device for High Throughput Massively Parallel Sonication
    Kevin Oldenburg; Fiscal Year: 2006
    ..The goal of this project is solve these problems by developing a high speed, massively parallel sonication system that can be used to drive precipitated compounds stored in each well of a 96, 384, or 1536-well plate ..
  17. DNA REPAIR STUDIES IN XERODERMA PIGMENTOSUM CELLS
    Kristien Mortelmans; Fiscal Year: 1980
    ..complementation experiments with XP complementation groups that are shown to be defective in excision repair, and (3) investigate the dimer-excising ability of normal and XP cell-free extracts prepared by methods other than sonication.
  18. IMMUNE RESPONSE AND GRAFT REJECTION
    HENRY WINN; Fiscal Year: 1990
    ..and those to tissues that have been devitalized by lyophilization, irradiation, treatment with glutaraldehyde, sonication, or heat...
  19. Identification of CBFA1 Targets in Osteoblasts
    Baruch Frenkel; Fiscal Year: 2003
    ..targets, we first showed that efficient ChIP could be performed using restriction enzyme digestion instead of sonication for fragmentation of the chromatin...
  20. Novel MRI Contrast Agent for Monitoring Thermal Ablation
    Nathan Mcdannold; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  21. BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUND
    Douglas Miller; Fiscal Year: 2001
    ..abstract_text> ..
  22. BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUND
    Douglas Miller; Fiscal Year: 2009
    ..This project will examine bioeffects in cells and tissues and show how to safely use ultrasound contrast agents in diagnostic imaging. ..
  23. ULTRASOUND ENHANCEMENT OF CANCER GENE THERAPY
    Douglas Miller; Fiscal Year: 2003
    ..This research will provide a bridge from the basic research breakthrough to specific therapeutic applications and urgently needed clinical research programs utilizing this novel technology. ..
  24. ULTRASOUND ENHANCEMENT OF CANCER GENE THERAPY
    Douglas Miller; Fiscal Year: 2002
    ..This research will provide a bridge from the basic research breakthrough to specific therapeutic applications and urgently needed clinical research programs utilizing this novel technology. ..
  25. Neurofeedback functional MRI
    Seung Schik Yoo; Fiscal Year: 2006
    ....
  26. Sonoporation as a new genetic tool for F. nucleatum
    Yiping Han; Fiscal Year: 2008
    ..nucleatum will be investigated. Our long term goal is to develop sonoporation into a robust tool for genetic manipulation of microorganisms [unreadable] [unreadable] [unreadable]..
  27. Biomimetic Nanofibrillar Scaffolds For Cartilage Tissue Engineering
    Anu Subramanian; Fiscal Year: 2008
    ..The engineering methodology developed in this proposal may have broader impacts on the manufacturing of other surfaces for tissue engineering. [unreadable] [unreadable] [unreadable]..
  28. Image-guided Ultrasound-triggered Tumor Therapy
    Alexander Klibanov; Fiscal Year: 2007
    ..Monitor blood flow within the tumor after treatment. Perform final optimization of the drug carrier formulation and ultrasound activation parameters. ..
  29. HIGH TEMPERATURE ULTRASOUND THERAPY GUIDED BY MRI
    Kullervo Hynynen; Fiscal Year: 2002
    ..These theoretical models are required for accurate multi focal pattern sonication planning and control of the treatments...
  30. CYTOMIMETIC ORGANIC CHEMISTRY
    FREDRIC MENGER; Fiscal Year: 2007
    ....
  31. Cloning and analysis of centrosome-associated RNA
    MARK ALLIEGRO; Fiscal Year: 2007
    ..If our hypothesis is correct, this study will reopen a line of inquiry with impact in areas of cell and developmental biology ranging from control of cell division to evolution of eukaryotes. [unreadable] [unreadable]..
  32. Heat Activated Gene Therapy Using Radiomimetic CdtB
    Michael Borrelli; Fiscal Year: 2007
    ..Consequently, complementary therapies that can improve local control for primary and recurrent cancers are needed. The proposed study will test the potential of heat-activated CdtB gene therapy to help satisfy this need. ..
  33. MR Guided Focused Ultrasound Surgery for Prostate Cancer
    Clare Tempany; Fiscal Year: 2009
    ..Thus, at the conclusion of this project we will be poised to begin larger phase II/III clinical trials, with an industrial partner leading to commercial development of a device for further trials. ..
  34. ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULL
    Kullervo Hynynen; Fiscal Year: 2002
    ..Fifth, to investigate the optimal sonication parameters to produce the desired physiologic or histologic end points using in vivo rabbit brain studies; and 6...
  35. Development and Characterization of a Novel Contrast Agent
    Margaret Wheatley; Fiscal Year: 2009
    ..A diagnostic tool that could safely and non-invasively detect tumors at an early stage, before metastasis, would be a great advance in health care. ..
  36. ACOUSTICALLY ACTIVATED MICELLAR DRUG DELIVERY
    Natalya Y Rapoport; Fiscal Year: 2010
    ....
  37. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen C Steere; Fiscal Year: 2010
    ..Furthermore, this work brings us closer to the long-term goal of direct comparisons of antigens in Lyme arthritis and rheumatoid arthritis synovia. ..
  38. Soft Tissue Biomechanical Behavior During Acupuncture in Low Back Pain
    Helene M Langevin; Fiscal Year: 2010
    ....
  39. CONSTITUTIVE STRESS PROTEINS AND STRESS TOLERANCE
    Michael Borrelli; Fiscal Year: 2002
    ....
  40. ACOUSTICALLY ACTIVATED MICELLAR DRUG DELIVERY
    Natalya Rapoport; Fiscal Year: 2001
    ....
  41. 2007 Elastin and Elastic Fibers Gordon Conference
    Elaine Davis; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  42. Mechanism of in-vitro aging
    LYSLE LEWIS; Fiscal Year: 2007
    ..The proposed research will enhance our understanding of events that occur as a consequence of shortened chromosomes and factors that affect the rate of shortening. [unreadable] [unreadable] [unreadable]..
  43. Contrast Enhanced Ultrasound with Therapeutic Modality
    Margaret Wheatley; Fiscal Year: 2004
    ..These studies are a prelude to show feasibility prior to in vivo studies. ..
  44. Dentin/Adhesive Interface Structure/Property Imaging
    Yong Wang; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  45. Drosophila Models of Prion Disease
    Surachai Supattapone; Fiscal Year: 2003
    ..These studies have relevance for prion diseases and other age-related, neurodegenerative illnesses associated with protein misfolding. ..
  46. Changes in the Cornified Cell Envelope in HPV Infection
    Darron Brown; Fiscal Year: 2006
    ..abstract_text> ..
  47. HIGH RESOLUTION BLOOD FLOW MAPPING IN OCULAR TISSUES
    Katherine Ferrara; Fiscal Year: 2003
    ..In conjunction with this study, mechanical damage to the vessel wall will be directly assessed through the use of fluorescent markers. ..
  48. MR GUIDED PROSTATE CANCER DIAGNOSIS AND BRACHYTHERAPY
    Clare Tempany; Fiscal Year: 2003
    ..An ultimate goal beyond the scope of this application is our collaboration with General Electric Medical systems (GEMS) on new MR-guided technical advances and an NSF funded project to develop medical robotics. ..
  49. Oral Immunology/Microbiology Research Group Annual Mtg
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  50. Oral Immunology/Microbiology Annual Meeting
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  51. Therapeutic Ultrasound Contrast Agent Dynamics Modeling
    CHAO TSUNG HSIAO; Fiscal Year: 2006
    ..In Phase II, the model can be extended to continue beyond shell break up and fragmentation and will address a cloud of contrast agents. [unreadable] [unreadable] [unreadable]..
  52. Bcr-Abl thiophosphorylation profiling in CML using MALDI
    Laurie Parker; Fiscal Year: 2006
    ..apos; ..
  53. H2S PRODUCTION AND VIRULENCE OF TREPONEMA DENTICOLA
    Lianrui Chu; Fiscal Year: 2007
    ..denticola to produce H2S from glutathione. The outcomes will elucidate the mechanisms of action that each member of the enzyme pathway plays in the virulence capacity of T. denticola. ..
  54. High-Speed Optical Imaging for Medical Diagnosis and Therapy
    OLIVER KRIPFGANS; Fiscal Year: 2007
    ..This camera is able to record images of these examinations and help us to better understand how to improve diagnosis and treatment. [unreadable] [unreadable] [unreadable]..
  55. The Development and Testing of a Sonic Treatment Brush for Diabetic Foot Ulcers
    ROBERT AKRIDGE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  56. Molecular/Mechanical Imaging of Dentin Bonding Substrate
    Yong Wang; Fiscal Year: 2007
    ..Results from this work will provide critical, new insight into failure mechanisms at the dentin/adhesive interface; failure that can ultimately lead to premature breakdown of the composite restoration. ..
  57. Local harmonic motion imaging for thermal surgery
    Kullervo Hynynen; Fiscal Year: 2006
    ..Therefore the potential clinical impact of the proposed research is significant. ..
  58. BIOMECHANICAL EFFECT OF ACUPUNCTURE NEEDLING
    HELENE LANGEVIN; Fiscal Year: 2001
    ..This will contribute to the fundamental understanding of acupuncture therapy and may lead to improvements in treatments. ..
  59. F.nucleatum in Amniotic Fluid Infection
    Yiping Han; Fiscal Year: 2004
    ..nucleatum for diagnostic purposes, and intervention studies aimed at reducing the incidence of preterm birth. ..
  60. CONTRAST ASSISTED ULTRASOUND IMAGING OF TUMORS
    Katherine Ferrara; Fiscal Year: 2006
    ..Since these hydrophobic drugs are now suspended in Cremophor for human use, a final aim is to develop acoustically-activated drug delivery vehicles that provide an alternative to the toxicity of Cremophor. ..
  61. Diagnosis and Pathogenesis of Early Lyme Disease
    Allen Steere; Fiscal Year: 2007
    ..In addition, greater knowledge of spirochetal virulence and host factors associated with severe disease may allow the development of laboratory markers for patients who would benefit from more intensive treatment. ..
  62. Opening of the Blood Brain Barrier for Molecular Imaging
    Kullervo Hynynen; Fiscal Year: 2007
    ..The development of even one such imaging method for routine clinical use would have a major impact on patient care. [unreadable] [unreadable]..