Genomes and Genes
Summary: The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications376 found, 100 shown here
- Toxic potential of materials at the nanolevelAndre Nel
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Science 311:622-7. 2006..The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable...
- Understanding biophysicochemical interactions at the nano-bio interfaceAndre E Nel
Division of NanoMedicine, David Geffen School of Medicine and California NanoSystems Institute at UCLA, Los Angeles, California 90095, USA
Nat Mater 8:543-57. 2009Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment...
- Folding DNA to create nanoscale shapes and patternsPaul W K Rothemund
Departments of Computer Science and Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA
Nature 440:297-302. 2006..Finally, individual DNA structures can be programmed to form larger assemblies, including extended periodic lattices and a hexamer of triangles (which constitutes a 30-megadalton molecular complex)...
- Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnologyMarie Christine Daniel
Molecular Nanosciences and Catalysis Group, LCOO, UMR CNRS No 5802, Universite Bordeaux I, 33405 Talence Cedex, France
Chem Rev 104:293-346. 2004
- Drug delivery systems: entering the mainstreamTheresa M Allen
Department of Pharmacology, University of Alberta, Edmonton T6G 2H7, Canada
Science 303:1818-22. 2004..Furthermore, there is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics...
- Effect of surface properties on nanoparticle-cell interactionsAyush Verma
Department of Materials Science and Engineering, Massachusetts Institute of Technology MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Small 6:12-21. 2010..Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed...
- The control of human mesenchymal cell differentiation using nanoscale symmetry and disorderMatthew J Dalby
Centre for Cell Engineering, Joseph Black Building, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK
Nat Mater 6:997-1003. 2007..In addition, the current studies show that topographically treated MSCs have a distinct differentiation profile compared with those treated with osteogenic media, which has implications for cell therapies...
- Stem cell fate dictated solely by altered nanotube dimensionSeunghan Oh
Department of Materials Science and Engineering, University California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 106:2130-5. 2009..cell elongation (approximately 10-fold increased), which induced cytoskeletal stress and selective differentiation into osteoblast-like cells, offering a promising nanotechnology-based route for unique orthopedics-related hMSC treatments.
- Challenges and opportunities for structural DNA nanotechnologyAndre V Pinheiro
Center for Single Molecule Biophysics, The Biodesign Institute, Arizona State University, Tempe, USA
Nat Nanotechnol 6:763-72. 2011..Here we examine the technical challenges in the field of structural DNA nanotechnology and outline some of the promising applications that could be developed if these hurdles can be overcome...
- WSXM: a software for scanning probe microscopy and a tool for nanotechnologyI Horcas
Nanotec Electrónica S L, Centro Empresarial Euronova 3, Ronda de Poniente 2, Edificio 2 1a Planta Oficina A, 28760 Tres Cantos, E 28049 Madrid, Spain
Rev Sci Instrum 78:013705. 2007..Finally, a detailed discussion of some relevant procedures of the software is carried out...
- Cancer nanotechnology: opportunities and challengesMauro Ferrari
Division of Haematology and Oncology, 110U Davis Heart and Lung Research Institute, The Ohio State University, 473 West 12th Avenue, Columbus OH 43210 1002, USA
Nat Rev Cancer 5:161-71. 2005b>Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices derived from engineering, biology, physics and chemistry...
- Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidanceL R Hirsch
Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, TX 77251 1892, USA
Proc Natl Acad Sci U S A 100:13549-54. 2003..Tissues heated above the thermal damage threshold displayed coagulation, cell shrinkage, and loss of nuclear staining, which are indicators of irreversible thermal damage. Control tissues appeared undamaged...
- Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dotsXingyong Wu
Quantum Dot Corporation, 26118 Research Rd, Hayward, CA 94545, USA
Nat Biotechnol 21:41-6. 2003..The results indicate that QD-based probes can be very effective in cellular imaging and offer substantial advantages over organic dyes in multiplex target detection...
- Impact of nanotechnology on drug deliveryOmid C Farokhzad
Laboratory of Nanomedicine and Biomaterials and Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
ACS Nano 3:16-20. 2009b>Nanotechnology is the engineering and manufacturing of materials at the atomic and molecular scale...
- Self-assembly of DNA into nanoscale three-dimensional shapesShawn M Douglas
Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 459:414-8. 2009..We anticipate that our strategy for self-assembling custom three-dimensional shapes will provide a general route to the manufacture of sophisticated devices bearing features on the nanometre scale...
- Self-assembly at all scalesGeorge M Whitesides
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
Science 295:2418-21. 2002..The concept of self-assembly is used increasingly in many disciplines, with a different flavor and emphasis in each...
- Dynamic DNA nanotechnology using strand-displacement reactionsDavid Yu Zhang
Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, Room 530, Boston, Massachussetts 02115, USA
Nat Chem 3:103-13. 2011..Although it had initially focused on the self-assembly of static structures, DNA nanotechnology is now also becoming increasingly attractive for engineering systems with interesting dynamic properties...
- Nanotechnology in drug delivery and tissue engineering: from discovery to applicationsJinjun Shi
MIT Harvard Center for Cancer Nanotechnology Excellence, Laboratory of Nanomedicine and Biomaterials, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nano Lett 10:3223-30. 2010The application of nanotechnology in medicine, referred to as nanomedicine, is offering numerous exciting possibilities in healthcare...
- Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicologyG Oberdorster
Department of Environmental Medicine, University of Rochester, 601 Elmwood Avenue, Medical Center, Rochester, NY 14642, USA
J Intern Med 267:89-105. 2010b>Nanotechnology, nanomedicine and nanotoxicology are complementary disciplines aimed at the betterment of human life...
- Exploring and engineering the cell surface interfaceMolly M Stevens
Department of Materials and Institute for Biomedical Engineering, Imperial College of Science, Technology, and Medicine, Prince Consort Road, London SW7 2BP, UK
Science 310:1135-8. 2005..Far-reaching implications are emerging for applications including medical implants, cell supports, and materials that can be used as instructive three-dimensional environments for tissue regeneration...
- Antimicrobial applications of nanotechnology: methods and literatureJustin T Seil
Laboratory for Nanomedicine Research, School of Engineering, Brown University, Providence, RI 02917, USA
Int J Nanomedicine 7:2767-81. 2012..Consequently, new methods for reducing bacteria activity (and associated infections) are badly needed. Nanotechnology, the use of materials with dimensions on the atomic or molecular scale, has become increasingly utilized for ..
- Direct multiplexed measurement of gene expression with color-coded probe pairsGary K Geiss
NanoString Technologies Inc, 201 Elliott Ave West, Suite 300, Seattle, Washington 98119, USA
Nat Biotechnol 26:317-25. 2008..Finally, a comparison of transcript levels for 21 genes across seven samples measured by the nCounter system and SYBR Green real-time PCR demonstrated similar patterns of gene expression at all transcript levels...
- Safe handling of nanotechnologyAndrew D Maynard
Woodrow Wilson International Center for Scholars, USA
Nature 444:267-9. 2006
- DNA in a material worldNadrian C Seeman
Department of Chemistry, New York University, New York 10003, USA
Nature 421:427-31. 2003..This powerful molecular recognition system can be used in nanotechnology to direct the assembly of highly structured materials with specific nanoscale features, as well as in DNA ..
- Current advances in research and clinical applications of PLGA-based nanotechnologyJian ming Lu
Michael E DeBakey Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, Baylor College of Medicine, Houston, TX 77030, USA
Expert Rev Mol Diagn 9:325-41. 2009Co-polymer poly(lactic-co-glycolic acid) (PLGA) nanotechnology has been developed for many years and has been approved by the US FDA for the use of drug delivery, diagnostics and other applications of clinical and basic science research, ..
- Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteinsJwa Min Nam
Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60201, USA
Science 301:1884-6. 2003..Comparable clinically accepted conventional assays for detecting the same target have sensitivity limits of approximately 3 picomdar, six orders of magnitude less sensitive than what is observed with this method...
- Nanoparticle and targeted systems for cancer therapyLisa Brannon-Peppas
Department of Biomedical Engineering, The University of Texas at Austin, 1 University Station, C0800, Austin, TX 78712 0231, USA
Adv Drug Deliv Rev 56:1649-59. 2004..Delivery methods that specifically use nanoparticles are also highlighted, including both degradable and nondegradable polymers...
- The use of nanocrystals in biological detectionPaul Alivisatos
University of California Berkeley, Department of Chemistry, B60 Hildebrand Hall, Berkeley, California 94720 1460, USA
Nat Biotechnol 22:47-52. 2004....
- Continuous base identification for single-molecule nanopore DNA sequencingJames Clarke
Oxford Nanopore Technologies Ltd, Begbroke Science Park, Sandy Lane, Oxford OX5 1PF, UK
Nat Nanotechnol 4:265-70. 2009..This highly accurate tool is suitable for integration into a system for sequencing nucleic acids and for analysing epigenetic modifications...
- Activation of integrin function by nanopatterned adhesive interfacesMarco Arnold
University of Heidelberg, Institute for Physical Chemistry, Biophysical Chemistry, INF 253, 69120 Heidelberg, Germany
Chemphyschem 5:383-8. 2004..We propose that the range between 58-73 nm is a universal length scale for integrin clustering and activation, since these properties are shared by a variety of cultured cells...
- Exosome nanotechnology: an emerging paradigm shift in drug delivery: exploitation of exosome nanovesicles for systemic in vivo delivery of RNAi heralds new horizons for drug delivery across biological barriersSamira Lakhal
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
Bioessays 33:737-41. 2011....
- Bioconjugated quantum dots for in vivo molecular and cellular imagingAndrew M Smith
Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA
Adv Drug Deliv Rev 60:1226-40. 2008..We also examine key issues for in vivo imaging and therapy, such as nanoparticle biodistribution, pharmacokinetics, and toxicology...
- Nanomedicine: current status and future prospectsS Moein Moghimi
Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, UK
FASEB J 19:311-30. 2005Applications of nanotechnology for treatment, diagnosis, monitoring, and control of biological systems has recently been referred to as "nanomedicine" by the National Institutes of Health...
- Self-assembled monolayers of thiolates on metals as a form of nanotechnologyJ Christopher Love
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
Chem Rev 105:1103-69. 2005
- Electrospinning of collagen nanofibersJamil A Matthews
Department of Physiology, Virginia Commonwealth University, Richmond, Virginia 23298 0551, USA
Biomacromolecules 3:232-8. 2002..The structural, material, and biological properties of electrospun collagen suggest that this material may represent a nearly ideal tissue engineering scaffold...
- The emerging field of RNA nanotechnologyPeixuan Guo
Nanobiomedical Center, College of Engineering and College of Medicine, University of Cincinnati, Cincinnati, Ohio 45221, USA
Nat Nanotechnol 5:833-42. 2010..Although RNA nanotechnology resembles DNA nanotechnology in many ways, the base-pairing rules for constructing nanoparticles are different...
- Neural network computation with DNA strand displacement cascadesLulu Qian
Bioengineering, California Institute of Technology, Pasadena, California 91125, USA
Nature 475:368-72. 2011..Our results suggest that DNA strand displacement cascades could be used to endow autonomous chemical systems with the capability of recognizing patterns of molecular events, making decisions and responding to the environment...
- Noninvasive detection of clinically occult lymph-node metastases in prostate cancerMukesh G Harisinghani
Massachusetts General Hospital and Harvard Medical School, Boston, USA
N Engl J Med 348:2491-9. 2003....
- Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imagingJae Hyun Lee
Department of Chemistry and Nanomedical National Core Research Center, Yonsei University, Seoul 120 749, Korea
Nat Med 13:95-9. 2007..Also, we successfully visualized small tumors implanted in a mouse. Such high-performance, nanotechnology-based molecular probes could enhance the ability to visualize other biological events critical to diagnostics ..
- DNA-assisted dispersion and separation of carbon nanotubesMing Zheng
DuPont Central Research and Development, Experimental Station, Wilmington, Delaware 19880, USA
Nat Mater 2:338-42. 2003..This finding links one of the central molecules in biology to a technologically very important nanomaterial, and opens the door to carbon-nanotube-based applications in biotechnology...
- In vitro toxicity of silver nanoparticles at noncytotoxic doses to HepG2 human hepatoma cellsKoji Kawata
Department of Urban and Environmental Engineering, Graduate School of Engineering, Hokkaido University, North 13, West 8, Kita ku, Sapporo 060 8628, Japan
Environ Sci Technol 43:6046-51. 2009..Based on these discussions, it is concluded that both "nanosized particle of Ag" as well as "ionic Ag+" contribute to the toxic effects of Ag-NPs...
- Molecular robots guided by prescriptive landscapesKyle Lund
Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287, USA
Nature 465:206-10. 2010....
- Application of nanotechnology in cancer therapy and imagingXu Wang
Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
CA Cancer J Clin 58:97-110. 2008Recent developments in nanotechnology have provided researchers with new tools for cancer imaging and treatment...
- Progress in antiretroviral drug delivery using nanotechnologyRama Mallipeddi
University of Pittsburgh, Department of Pharmaceutical Sciences, School of Pharmacy, Magee Womens Research Institute, Pittsburgh, PA, USA
Int J Nanomedicine 5:533-47. 2010..Their application in the area of HIV prevention and therapy may lead to the development of more effective drug products for combating this pandemic disease...
- Typing Chlamydia trachomatis: from egg yolk to nanotechnologyLisbeth Nørum Pedersen
Department of Clinical Microbiology, Aarhus University Hospital, Skejby, Denmark
FEMS Immunol Med Microbiol 55:120-30. 2009..The futuristic nanotechnology already seems at hand to further simplify and automate the high-resolution genotyping method based on NAAT and ..
- An application of nanotechnology in advanced dental materialsSumita B Mitra
3M ESPE Dental Products, St Paul, Minn 55144, USA
J Am Dent Assoc 134:1382-90. 2003..This article reports the authors' development of nanofillers and a resulting nanocomposite. They measured the nanocomposite's properties in vitro in comparison with those of several existing composites (hybrids, microhybrids and microfill)...
- Magnetic tweezers: micromanipulation and force measurement at the molecular levelCharlie Gosse
Laboratoire de Physique Statistique, Ecole Normale Superieure, Unité de Recherche 8550 associée au Centre National de la Recherche Scientifique et aux Universités Paris VI et VII, 75231 Paris, France
Biophys J 82:3314-29. 2002..From those experiments, we conclude that magnetic tweezers represent a low-cost and biocompatible setup that could become a suitable alternative to the other available micromanipulators...
- Soft lithography for micro- and nanoscale patterningDong Qin
Nano Research Facility and Department of Energy, Environmental, and Chemical Engineering, Washington University, St Louis, Missouri, USA
Nat Protoc 5:491-502. 2010....
- Reducing infections through nanotechnology and nanoparticlesErik Taylor
School of Engineering, Brown University, Providence, RI 02917, USA
Int J Nanomedicine 6:1463-73. 2011..review article will first examine in detail the mechanisms and applications of some of these nanoparticles, then follow with some recent material designs utilizing nanotechnology that are centered on fighting medical device infections.
- Folding DNA into twisted and curved nanoscale shapesHendrik Dietz
Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Science 325:725-30. 2009..We also combined multiple curved elements to build several different types of intricate nanostructures, such as a wireframe beach ball or square-toothed gears...
- Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticlesJ F Hillyer
Department of Animal Health and Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 1656 Linden Drive, Madison, Wisconsin 53706, USA
J Pharm Sci 90:1927-36. 2001..To our knowledge this is the first report, at the ultrastructural level, of gastrointestinal uptake of particulates by persorption through holes created by extruding enterocytes...
- Lipid-based nanoparticles as pharmaceutical drug carriers: from concepts to clinicAnu Puri
Center for Cancer Research Nanobiology Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702 1201, USA
Crit Rev Ther Drug Carrier Syst 26:523-80. 2009In recent years, various nanotechnology platforms in the area of medical biology, including both diagnostics and therapy, have gained remarkable attention...
- Filamentous bacteriophage: biology, phage display and nanotechnology applicationsJasna Rakonjac
Institute of Molecular Biosciences, Massey University, Palmerston North, New Zealand
Curr Issues Mol Biol 13:51-76. 2011..In the first half of the review, both the Ff and temperate phage are described and compared. A large section of the review is devoted to an overview of phage display technology and its applications in nanotechnology.
- Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticlesShanta Dhar
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 105:17356-61. 2008..The effectiveness of PSMA targeted Pt-NP-Apt nanoparticles against the PSMA(+) LNCaP cells is approximately an order of magnitude greater than that of free cisplatin...
- DNA nanomachinesJonathan Bath
University of Oxford, Department of Physics, Clarendon Laboratory, Parks Road, Oxford OX1 3PU, UK
Nat Nanotechnol 2:275-84. 2007..It has even proved possible to create DNA motors that move autonomously, obtaining energy by catalysing the reaction of DNA or RNA fuels...
- Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detectionYunWei Charles Cao
Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
Science 297:1536-40. 2002..Six dissimilar DNA targets with six Raman-labeled nanoparticle probes were distinguished, as well as two RNA targets with single nucleotide polymorphisms. The current unoptimized detection limit of this method is 20 femtomolar...
- Nanoparticle interaction with biological membranes: does nanotechnology present a Janus face?Pascale R Leroueil
Program in Macromolecular Science and Engineering, Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
Acc Chem Res 40:335-42. 2007....
- Electrospun nanofibrous structure: a novel scaffold for tissue engineeringWan Ju Li
School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, USA
J Biomed Mater Res 60:613-21. 2002..This novel biodegradable scaffold has potential applications for tissue engineering based upon its unique architecture, which acts to support and guide cell growth...
- New approaches to nanofabrication: molding, printing, and other techniquesByron D Gates
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
Chem Rev 105:1171-96. 2005
- Electrochemical DNA sensorsT Gregory Drummond
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
Nat Biotechnol 21:1192-9. 2003....
- Role of nanotechnology in pharmaceutical product developmentHarikrishna Devalapally
Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 110 Mugar Life Sciences Building, Boston, Massachusetts 02115, USA
J Pharm Sci 96:2547-65. 2007..This review summarizes some of the parameters and approaches that can be used to evaluate nanoparticulate drug delivery systems in early stages of formulation development...
- A robust DNA mechanical device controlled by hybridization topologyHao Yan
Department of Chemistry, New York University, New York, NY 10003, USA
Nature 415:62-5. 2002..We expect that a wide range of analogous yet distinct rotary devices can be created by changing the control strands and the device sequences to which they bind...
- The University of California Center for the Environmental Implications of NanotechnologyHilary A Godwin
University of California, School of Public Health, Los Angeles, CA, USA
Environ Sci Technol 43:6453-7. 2009..Assessing nanomaterialsfor human health and ecotoxicological impact can be well aided by using high-throughput laboratory methods...
- Live-cell photoactivated localization microscopy of nanoscale adhesion dynamicsHari Shroff
Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, USA
Nat Methods 5:417-23. 2008..By allowing observation of a wide variety of nanoscale dynamics, live-cell PALM provides insights into molecular assembly during the initiation, maturation and dissolution of cellular processes...
- Graphene as a subnanometre trans-electrode membraneS Garaj
Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA
Nature 467:190-3. 2010..The sensitivity of graphene's in-plane electronic conductivity to its immediate surface environment and trans-membrane solution potentials will offer new insights into atomic surface processes and sensor development opportunities...
- Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug deliveryRajni Sinha
Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, Room 3090, Atlanta, GA 30322, USA
Mol Cancer Ther 5:1909-17. 2006b>Nanotechnology refers to the interactions of cellular and molecular components and engineered materials-typically, clusters of atoms, molecules, and molecular fragments into incredibly small particles-between 1 and 100 nm...
- DNA origami with complex curvatures in three-dimensional spaceDongran Han
The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
Science 332:342-6. 2011..A series of DNA nanostructures with high curvature--such as 2D arrangements of concentric rings and 3D spherical shells, ellipsoidal shells, and a nanoflask--were assembled...
- Electrospun P(LLA-CL) nanofiber: a biomimetic extracellular matrix for smooth muscle cell and endothelial cell proliferationX M Mo
Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, 117576, Singapore, Singapore
Biomaterials 25:1883-90. 2004..The biocompatibility of the nanofiber scaffold has been investigated by culturing cells on the nanofiber scaffold. Both smooth muscle cell and endothelial cell adhered and proliferated well on the P(LLA-CL) nanofiber scaffolds...
- Programmable nanowire circuits for nanoprocessorsHao Yan
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Nature 470:240-4. 2011....
- A bipedal DNA Brownian motor with coordinated legsTosan Omabegho
School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
Science 324:67-71. 2009..This device should be able to fulfill roles that entail the performance of useful mechanical work on the nanometer scale...
- Towards the application of cytoskeletal motor proteins in molecular detection and diagnostic devicesTill Korten
Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany
Curr Opin Biotechnol 21:477-88. 2010..This opens up the opportunity to design highly integrated, miniaturized, autonomous detection devices. Such devices, in turn, may allow fast and cheap on-site diagnosis of diseases and detection of environmental pathogens and toxins...
- Selective differentiation of neural progenitor cells by high-epitope density nanofibersGabriel A Silva
Institute for Bioengineering and Nanoscience in Advanced Medicine, Northwestern University, Chicago, IL 60611, USA
Science 303:1352-5. 2004..This rapid selective differentiation is linked to the amplification of bioactive epitope presentation to cells by the nanofibers...
- Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: implications for drug and gene deliveryJayanth Panyam
Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
FASEB J 16:1217-26. 2002..S. Food and Drug Administration. Hence PLGA is well suited for sustained intracellular delivery of macromolecules...
- Actin filament guidance on a chip: toward high-throughput assays and lab-on-a-chip applicationsMark Sundberg
Department of Chemistry and Biomedical Sciences, University of Kalmar, SE 39182 Kalmar, Sweden
Langmuir 22:7286-95. 2006..The results are discussed in relation to lab-on-a-chip applications and nanotechnology-assisted assays of actomyosin function.
- Imaging intracellular fluorescent proteins at nanometer resolutionEric Betzig
Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA 20147, USA
Science 313:1642-5. 2006....
- Types of neural guides and using nanotechnology for peripheral nerve reconstructionEsmaeil Biazar
Department of Chemistry, Islamic Azad University Tonekabon Branch, Iran
Int J Nanomedicine 5:839-52. 2010..types of artificial and natural guides, and methods to improve the performance of tubes, such as orientation, nanotechnology applications for nerve reconstruction, fibers and nanofibers, electrospinning methods, and their application ..
- Pharmaceutical nanotechnology for oral delivery of anticancer drugsLin Mei
Division of Life and Health Sciences, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
Adv Drug Deliv Rev 65:880-90. 2013..Pharmaceutical nanotechnology, which is to apply and further develop nanotechnology to solve the problems in drug delivery, may provide a ..
- Cellular nanotechnology: making biological interfaces smarterPaula M Mendes
School of Chemical Engineering, University of Birmingham, Birmingham, B15 2TT, UK
Chem Soc Rev 42:9207-18. 2013Recently, there has been an outburst of research on engineered cell-material interfaces driven by nanotechnology and its tools and techniques...
- Inception to actualization: next generation coronary stent coatings incorporating nanotechnologyAaron Tan
Centre for Nanotechnology and Regenerative Medicine, UCL Division of Surgery and Interventional Science, University College London UCL, London NW3 2QG, UK
J Biotechnol 164:151-70. 2013..The advent of nanotechnology has engendered techniques like layer-by-layer self-assembly, and localized drug and gene delivery using ..
- Nanoparticles and the immune systemBanu S Zolnik
Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Food and Drug Administration, Silver Spring, Maryland 20993, USA
Endocrinology 151:458-65. 2010Today nanotechnology is finding growing applications in industry, biology, and medicine...
- Nanotechnology: convergence with modern biology and medicineMihail C Roco
National Science Foundation, Room 505, 4201 Wilson Blvd, Arlington, VA 22230, USA
Curr Opin Biotechnol 14:337-46. 2003The worldwide emergence of nanoscale science and engineering was marked by the announcement of the National Nanotechnology Initiative (NNI) in January 2000...
- Solid-state nanoporesCees Dekker
Kavli Institute of Nanoscience, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands
Nat Nanotechnol 2:209-15. 2007..The solid-state nanopore proves to be a surprisingly versatile new single-molecule tool for biophysics and biotechnology...
- The complex role of multivalency in nanoparticles targeting the transferrin receptor for cancer therapiesJin Wang
Departments of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA
J Am Chem Soc 132:11306-13. 2010....
- Cancer nanotechnology: application of nanotechnology in cancer therapyRanjita Misra
Institute of Life Sciences, Chandrasekharpur, Bhubaneswar, Orissa, India
Drug Discov Today 15:842-50. 2010The application of nanotechnology for cancer therapy has received considerable attention in recent years...
- Graphene/AuNPs/chitosan nanocomposites film for glucose biosensingChangsheng Shan
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Graduate University of the Chinese Academy of Sciences, Changchun, PR China
Biosens Bioelectron 25:1070-4. 2010..The graphene/AuNPs/GOD/chitosan composites film shows prominent electrochemical response to glucose, which makes a promising application for electrochemical detection of glucose...
- Efficacy of transferrin-conjugated paclitaxel-loaded nanoparticles in a murine model of prostate cancerSanjeeb K Sahoo
Department of Pharmaceutical Sciences, Nebraska Medical Center, Omaha, NE 68198 6025, USA
Int J Cancer 112:335-40. 2004..In conclusion, sustained release NPs demonstrated greater antitumor activity following their conjugation to Tf ligand...
- Silanized surfaces for in vitro studies of actomyosin function and nanotechnology applicationsMark Sundberg
Department of Chemistry and Biomedical Sciences, University of Kalmar, SE 391 82 Kalmar, Sweden
Anal Biochem 323:127-38. 2003..Furthermore, TMCS derivatized glass also seems to offer several advantages over nitrocellulose for HMM adsorption in the ordinary in vitro motility assay...
- Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineeringC Y Xu
Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, 117576 Singapore, Singapore
Biomaterials 25:877-86. 2004....
- Actin-based metallic nanowires as bio-nanotransportersFernando Patolsky
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Nat Mater 3:692-5. 2004..These actin-based metallic wires and their nanotransporting funcionality introduce new concepts for developing biological/inorganic hybrid devices...
- DNA as supramolecular scaffold for functional molecules: progress in DNA nanotechnologyThomas J Bandy
University of Southampton, School of Chemistry, Highfield, Southampton SO17 1BJ, UK
Chem Soc Rev 40:138-48. 2011..Using selected examples of the recent literature, the diversity of the functionalities that have been incorporated into DNA strands is discussed...
- Nanoparticles of biodegradable polymers for clinical administration of paclitaxelSi Shen Feng
Division of Bioengineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
Curr Med Chem 11:413-24. 2004....
- Label-free biomarker detection from whole bloodEric Stern
Department of Biomedical Engineering, School of Engineering and Applied Science, Yale University, New Haven, Connecticut 06511, USA
Nat Nanotechnol 5:138-42. 2010..This study marks the first use of label-free nanosensors with physiological solutions, positioning this technology for rapid translation to clinical settings...
- Ten years of tension: single-molecule DNA mechanicsCarlos Bustamante
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
Nature 421:423-7. 2003..These studies have illuminated the nature of interactions between DNA and proteins, the constraints within which the cellular machinery operates, and the forces created by DNA-dependent motors...
- Dendrimers in biomedical applications--reflections on the fieldSonke Svenson
Dendritic NanoTechnologies, Inc, 2625 Denison Drive, Mount Pleasant, MI 48858, USA
Adv Drug Deliv Rev 57:2106-29. 2005..The reflections on biomedical applications of dendrimers given in this review clearly demonstrate the potential of this new fourth major class of polymer architecture and indeed substantiate the high hopes for the future of dendrimers...
- Nanotechnology and HIV: potential applications for treatment and preventionPeter S Kim
Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Wiley Interdiscip Rev Nanomed Nanobiotechnol 2:693-702. 2010..The capabilities inherent to nanotechnology hold much potential for impact in the field of HIV treatment and prevention...
- Emerging nanotechnology approaches for HIV/AIDS treatment and preventionTewodros Mamo
Laboratory of Nanomedicine and Biomaterials, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Nanomedicine (Lond) 5:269-85. 2010..b>Nanotechnology is an emerging multidisciplinary field that is revolutionizing medicine in the 21st century...
- From nanotechnology to nanomedicine: applications to cancer researchR Seigneuric
Département Nanosciences, Laboratoire Interdisciplinaire Carnot de Bourgogne, CNRS UMR 5209, 9, Avenue Alain Savary, BP 47870, 21078 Dijon Cedex, France
Curr Mol Med 10:640-52. 2010..This translational review aims at integrating some recent advances from micro- and nano-technologies with high potential for improving daily oncology practice...
- Directed self-assembly of nanoparticlesMarek Grzelczak
Departamento de Quimica Fisica and Unidad Asociada CSIC Universidade de Vigo, 36310 Vigo, Spain
ACS Nano 4:3591-605. 2010Within the field of nanotechnology, nanoparticles are one of the most prominent and promising candidates for technological applications...
- Nanotechnology applied to the treatment of malariaNereide Stela Santos-Magalhães
Laboratório de Imunopatologia Keizo Asami LIKA, Universidade Federal de Pernambuco UFPE, Recife, PE, Brazil
Adv Drug Deliv Rev 62:560-75. 2010..This review emphasizes the main requirements for developing new nanotechnology-based carriers as a promising choice in malaria treatment, especially in the case of severe cerebral malaria.
- Single-nucleotide discrimination in immobilized DNA oligonucleotides with a biological nanoporeDavid Stoddart
Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom
Proc Natl Acad Sci U S A 106:7702-7. 2009..The additional steps required to enable nanopore DNA sequencing are outlined...
- Electrospinning of polymeric nanofibers for tissue engineering applications: a reviewQuynh P Pham
Department of Bioengineering, Rice University, Houston, Texas 77251 1892, USA
Tissue Eng 12:1197-211. 2006....
- Hybrid Nanoparticles in Imaging and Therapy of Prostate*Kattesh Katti; Fiscal Year: 2009The University of Missouri (MU) Cancer Nanotechnology Platform (CNP) is the culmination of long-standing interdisciplinary partnerships in departments within the School of Medicine, the College of Arts and Science, the College of ..
- Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator ArraysRyan Bailey; Fiscal Year: 2009..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
- Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseasesRobert M Weiss; Fiscal Year: 2010..Our first test of these nanoparticles will use a mouse model of bladder cancer. Thus, we can determine the therapeutic potential of siRNA for treatment of urologic diseases. ..
- Nanopolymersomes for Transcutaneous Co-Delivery of Vaccine Antigens and AdjuvantsPAUL CAMILLE TUMEH; Fiscal Year: 2013..plan is to become an independent physician-scientist investigator focused on the synthesis and utilization of nanotechnology systems for needle-free transcutaneous immunotherapeutics...
- Alzheimer's Disease TherapeuticTrevor P Castor; Fiscal Year: 2012..hydrophobic molecules such as bryostatin 1 in stable, readily bioavailable oil-based formulations, and novel nanotechnology formulations of bryostatin 1 that will further improve oral bioavailability...
- Nanoemulsion-based vaccine for chronic hepatitis B virusJames R Baker; Fiscal Year: 2010..NanoBio Corporation (Ann Arbor, MI) and the University of Michigan, Michigan Nanotechnology Institute for Medicine and Biological Sciences are developing a nanoemulsion (NE) based adjuvant to enhance ..
- Brain Delivery of Nanoformulated Superoxide DismutaseErin G Rosenbaugh; Fiscal Year: 2013..In addition to the proposed scientific research, this fellowship will support the applicant's participation in nanotechnology-based coursework and career development.
- Theranostic Nanomedicine for Breast Cancer Prevention and Image-Guided TherapyPrakash R Rai; Fiscal Year: 2011DESCRIPTION (provided by applicant): This proposal uses a nanotechnology and optical imaging-based strategy for prevention (AIM 1) and image-guided treatment (Aim 2) of breast cancer (BrCa) by targeting several key molecular targets in ..
- Detection of engineered nanomaterials in drinking water, food, commercial productPaul K Westerhoff; Fiscal Year: 2010b>Nanotechnology is rapidly resulting in the production of nanomaterials (NMs) that will be used in everything from toothpaste to pesticides, yet the research community lacks adequate techniques to measure the size and concentration of ..
- Lung Toxicity of Carbon Nanotubes in Models of Pre-Existing Respiratory DiseaseJAMES CHRISTOPHER BONNER; Fiscal Year: 2010DESCRIPTION (provided by applicant): Rapid advances in nanotechnology will be accompanied by the exposure of millions of individuals to products containing nanomaterials...
- Theranostic Nanomedicine for Breast Cancer Prevention and Image-Guided TherapyPrakash R Rai; Fiscal Year: 2013Abstract This proposal uses a nanotechnology and optical imaging-based strategy for prevention (AIM 1) and image- guided treatment (Aim 2) of breast cancer (BrCa) by targeting several key molecular targets in 3D cultures and orthotopic ..
- Nanodiagnostics and Nanotherapeutics: Building Research Ethics and OversightSusan M Wolf; Fiscal Year: 2010..A focal area of development is nanodiagnostics and nanotherapeutics. These fields use nanotechnology to develop nanoscale tools for in vitro diagnostics, in vivo imaging agents, drugs and therapies, targeted ..
- Transport ATPases: From Molecules to MaladiesRajini Rao; Fiscal Year: 2010..for a deep, mechanistic understanding of human pathologies, paving the way for new therapies and advances in nanotechnology. An impetus for the conference is the rapidly growing number of diseases associated with Transport ATPases, ..
- Molecular mechanism of antiangiogenic properties of gold nanoparticlePriyabrata Mukherjee; Fiscal Year: 2013b>Nanotechnology is a burgeoning field and brings with it a myriad of opportunities and possibilities for advancing medical science and disease treatment...
- INTRACOCHLEAR ELECTROCHEMICAL GRADIENTSAlexander A Spector; Fiscal Year: 2012..physical principles underlying the outer hair cell motor will contribute to the emerging field of biological nanotechnology. These studies may lead to improved therapeutic interventions for the hearing impaired...
- Mechanisms of Virus Replication and Gene ExpressionANNE ELIZABETH SIMON; Fiscal Year: 2013..range of expertise, from cellular and molecular biology to genomics and evolution, and from biochemistry to nanotechnology and vaccine development Trainees progress through innovative rotations, advanced courses in molecular and ..
- Influenza therapy by Au-nanorod 5'PPP-NS1-siRNA/cDNA targeting of bronchial cellsPaul R Knight; Fiscal Year: 2010..prophylactic and therapeutic non-viral gene transfer strategies that target pulmonary cells in vivo employing nanotechnology. The lung is especially well suited for these treatment strategies as direct contact with the environment ..
- Low Cost Diagnosis of Disease using Synthetic DNA ReactionsWilliam L Hughes; Fiscal Year: 2013..discovery, and characterization of zinc oxide nanostructures for piezoelectric applications towards DNA-based nanotechnology for medical benefit...
- Role of CD98 Glycoprotein in Intestinal InflammationHamed Laroui; Fiscal Year: 2013..The efficacy of knockdown of CD98 expression in inflamed colon will subsequently be assessed using a targeted nanotechnology approach...
- Multifunctional nanoparticles to improve treatment of human glioblastomaMiqin Zhang; Fiscal Year: 2013..This strategy combines the advances in forefront research of GBM cancer biology with advanced nanotechnology in tumor imaging and therapeutics to circumvent the resistance to treatment...
- Designing an Integrated Nanoscale System for Ion Channel Structure-Function StudyRatneshwar Lal; Fiscal Year: 2013DESCRIPTION (provided by applicant): Overall goal of this application is to design and develop nanotechnology to study key nanoscale biostructures - Ion channels and receptors that are essential for all living functions...
- Microvascular Health and Nanoparticle ExposureTimothy R Nurkiewicz; Fiscal Year: 2010..morbidity and mortality) from exposure to larger particles and the considerably dynamic nature of nanotechnology, identifying the health effects of nanoparticle exposure may prove far more challenging...
- Personalized therapeutics for inhibiting breast cancer metastasisDEBRA AUGUSTE; Fiscal Year: 2012..I propose to use our knowledge and experience in chemical engineering, material science, and nanotechnology to develop therapeutics that will increase breast cancer patient survival by inhibiting tumor progression and ..
- Nanotechnology for Multiplexed and Intraoperative Cancer DetectionShuming Nie; Fiscal Year: 2010..DESCRIPTION (Provided by the applicant): This GO grant application aims to integrate the unique capabilities of nanotechnology and innovative optical instrumentation for broad applications in cancer surgery...
- Long-Term Non-Enzymatic Glucose Sensors for an Artificial PancreasNATALIE ANN WISNIEWSKI; Fiscal Year: 2013..Multiple nanotechnology-based stabilizing agents will be employed...
- Understanding and Eliminating Oncogenic EGFR Signaling in Malignant GliomaAlain Charest; Fiscal Year: 2013..5) To ascertain toxicity profiles and efficacy spectrum of various nanotechnology platforms for the efficient delivery of small interfering RNA (siRNA) molecules to GBM tumor cells in vivo...
- Nanoparticle Analysis of Enveloped Virus Entry PathwaysRobert Davey; Fiscal Year: 2009DESCRIPTION (provided by applicant): In the field of nanotechnology, much attention has been paid to the construction of nanometer- sized particles that can harbor drugs and other therapeutic agents...
- siRNA-gold nanoparticle mediated ganglioside depletion for diabetic wound healingAMY SUSAN PALLER; Fiscal Year: 2013..We propose that genetic inhibition of ganglioside synthesis through the use of a novel nanotechnology approach will reverse impaired wound healing in KCs under high glucose conditions and in diabetic mice...
- QD-BRET nanosensors for protease detection and imagingJianghong Rao; Fiscal Year: 2012..This research proposes to develop a novel nanotechnology-based sensing and imaging system for sensitive, accurate, and multiplex detection and imaging of MMPs in ..
- Genetic Susceptibility to Nanoparticle-Induced Respiratory DiseaseJAMES CHRISTOPHER BONNER; Fiscal Year: 2013DESCRIPTION (provided by applicant): Rapid advances in nanotechnology will be accompanied by the exposure of millions of individuals to products containing nanomaterials...
- Nano-Antioxidants as a Therapeutic for Preclinical Models of NAFLDRobia G Pautler; Fiscal Year: 2013..activity, that do not pass radicals on to other molecules and that can be targeted, we have turned to nanotechnology. These nano-antioxidants, polyethylene glycolated hydrophilic carbon clusters (PEG-HCCs), are based on carbon ..
- TRAINING IN BIOMOLECULAR PHARMACOLOGYDavid H Farb; Fiscal Year: 2013..genomics, gene therapy, proteomics, animal models (transgenic and behavioral), structural biology, nanotechnology, systems biology and medicinal chemistry...
- Tri-modal Polymeric Micelles for 'See &Treat'Applications in Surgical OncologyGlen S Kwon; Fiscal Year: 2012..The goal is to develop nanotechnology for "see and treat" modalities in surgical oncology, enabled by polymeric micelles that emit tissue ..
- Rapid Novel Molecular Detection of Methicillin-Resistant Staphylococcus aureusELENA ANATOLIEVNA USACHEVA; Fiscal Year: 2010..to integrate our algorithm with their nanotechnology and detection platform and evaluate the feasibility for developing a reliable, cost-effective diagnostic ..
- Defining Target Contribution to Orofacial Pain by Antisense OligonucleotidesZhigang Luo; Fiscal Year: 2009..One is to use novel nanotechnology in delivering agents with therapeutic potential to block injury-induced orofacial pain and target gene ..
- Molecularly guided multimodal theranostics for breast cancerAmit Joshi; Fiscal Year: 2013..Hence, the early thrust of cancer nanotechnology was focused towards the development of nanocarriers for delivering diagnostic/therapeutic payloads to improve ..
- Boosting anti-tumor immune responses by modulating genes with nanoparticlesJose R Conejo-Garcia; Fiscal Year: 2010..To accomplish these aims, we have assembled a multidisciplinary team combining expertise in nanotechnology and tumor immunology...
- Integrative Cancer Nanoscience and Microsystems (IC-NSMS) Training CenterJanet M Oliver; Fiscal Year: 2013..IC-NSMS training via a boot camp to immerse new students in the integration of cancer biology and nanotechnology, an oncologist-led seminar on real-world problems in cancer prevention, detection and treatment and an ..
- Instrument for Single Molecule Sequencing of Alzheimer's-Relevant Genomic OxidatiDavid E Wolf; Fiscal Year: 2012..proposes to develop a single molecule DNA sequencing nanotechnology sensitive to a wide variety of DNA modifications, including those central to the pathogenesis of Alzheimer&..
- Asia-ARVO Travel Awards and SymposiumSally S Atherton; Fiscal Year: 2010..NIH including translational research, global health, high throughput technologies (genomics, proteomics, and nanotechnology), and health disparities...
- Nanoconjugate based on polymalic acid for brain tumor treatmentJulia Y Ljubimova; Fiscal Year: 2013DESCRIPTION (provided by applicant): Recent advances in nanotechnology may offer a new hope for a significant improvement and success of cancer treatment, especially in preventing tumor growth and progression...
- Cigarette Smoke and Autophagy/Lysosomal Pathway DysfunctionMartha M Monick; Fiscal Year: 2013..macrophages will be investigated using state-of-the-art facilities available in the University of Iowa, Nanotechnology Institute...
- MicroRNA pathway in mechanisms of nanoparticles neurotoxicityAlexander K Murashov; Fiscal Year: 2010..These cylindrical structures have novel properties that make them useful in many applications in nanotechnology, electronics, optics, as well as in medicine...
- Alzheimer's Drug Discovery Using Unique Nanotechnology PlatformWilliam L Klein; Fiscal Year: 2013..This project is expected to have strong potential to identify lead compounds that target binding of synaptotoxic Ab oligomers to their receptors, an underexploited but critical early-step in AD pathogenesis. ..
- Hybridization Chain Reaction: In Situ Amplification for Biological ImagingNiles A Pierce; Fiscal Year: 2013..Here, we draw on concepts from the field of nucleic acid nanotechnology to design and validate in situ am- plifiers based on the mechanism of hybridization chain reaction (HCR)...
- Bio-imaging with Isothermal DNA Self-AssemblyDavid Yu Zhang; Fiscal Year: 2013..DNA nanotechnology can, in principle, improve bio-imaging performance in all four categories, but conventional DNA nanotechnology ..
- Bio-imaging with Isothermal DNA Self-AssemblyDavid Yu Zhang; Fiscal Year: 2013..DNA nanotechnology can, in principle, improve bio-imaging performance in all four categories, but conventional DNA nanotechnology ..
- Targeted Gene Therapy and Nanomedicine Approaches to Treat Corneal DiseasesRAJIV RAVINDRA MOHAN; Fiscal Year: 2012..for transporting therapeutic genes into keratocytes of the rabbit cornea in vivo, can provide safe and novel nanotechnology-based nonviral gene therapy modalities to treat corneal diseases, and targeted delivery genes disabling ..
- Determination of Markers of High Pathogenicity in InfluenzaRichard A Dluhy; Fiscal Year: 2013..This project will ultimately demonstrate that bio-nanotechnology combined with vibrational spectroscopy has the ability to enhance detection and diagnosis of emerging viral ..
- Novel Influenza A Nanovaccines for Broad Cross ProtectionBaozhong Wang; Fiscal Year: 2013..We will use the newest nanotechnology approach to produce nanoclusters self-assembled directly from the resulting antigenic proteins as universal ..
- Interdisciplinary Biomedical Research Training ProgramSamuel L Jones; Fiscal Year: 2013..Engineering and Textiles, Statistics and Epidemiology, Biological Chemistry, and Pharmacology, Toxicology, and Nanotechnology. Research projects will emphasize the melding of two disciplines to create a novel approach to a biomedical ..
- Enzyme-Responsive Nanoemulsions as Tumor-Specific Ultrasound Contrast Agents forAndrew P Goodwin; Fiscal Year: 2011..Andrew Goodwin for a Pathway to Independence Award in Cancer Nanotechnology (RFA-CA-09-015)...
- Novel nanotechnology based oral influenza vaccinesSang Moo Kang; Fiscal Year: 2011..In our quest to advance to the next generation of vaccines using novel nanotechnology formulation, we propose to encapsulate influenza vaccines into stabilized small beadlike particles containing ..
- Computational Studies of Early Stage Cell Entry Events by Non-enveloped VirusesERIC ROBERT MAY; Fiscal Year: 2013..My interest in understanding elastic properties of viral capsids is both to enhance nanotechnology design efforts but also to understand morphological changes in capsids related to virus life cycle events...
- Training Grant in Academic NephrologyJOSEPH VINCENT BONVENTRE; Fiscal Year: 2013..fluid exchange, physiology and pharmacology of vasoactive hormones, human and mouse genetics, bioengineering, nanotechnology, tissue engineering, regenerative biology, and immunological mechanisms in kidney diseases...
- University of New Mexico Cancer Center SupportCheryl L Willman; Fiscal Year: 2013..mortality, and disparity;the integration of regional scientific strengths in engineering, biotechnology, nanotechnology, radioisotopes, drug discovery, imaging, and high performance computing into its Research Programs and Shared ..
- Nanotechnology for Minimally Invasive Cancer Detection and ResectionAaron M Mohs; Fiscal Year: 2011..The primary goal of this Pathway to Independence Award in Cancer Nanotechnology Research (K99/R00) proposal is to integrate the unique capabilities of nanotechnology with innovative optical ..
- Nanotechnology enabled desktop image-guided microbeam radiation therapy systemOTTO Z contact ZHOU; Fiscal Year: 2010..image guided radiation therapy system developed jointly with Siemens Oncology using the same enabling nanotechnology. The image guidance system is capable of 3D imaging in real time and during radiation delivery, a highly ..
- Enhancing Intestinal &Brain Uptake of Anti-AIDS DrugsPatrick J Sinko; Fiscal Year: 2013..Utilizing a nanotechnology approach, the proposed research will develop novel anti-HIV therapeutics that will dramatically increase ..
- A rapid label-free sensor for immune markers of environmental exposure for applicChristopher Striemer; Fiscal Year: 2012..The explosive growth of nanotechnology in research and consumer products (sunscreens, cosmetics, paint) is also creating an array of ultrafine ..
- Use of Silver Nanostructures on Microtransponders in Ultra-sensitive AssayWlodek Mandecki; Fiscal Year: 2011..The assay has a potential to also improve PCa disease management. Acceptance of nanotechnology-based multiplex assays on microtransponders by researchers and clinicians could initiate new methods in ..
- Nanotechnology-based Theranostic Technology for Bone Tissue EngineeringBalaji Sitharaman; Fiscal Year: 2010..in this application for the NIH Director's New Innovator Award is to engineer the next generation of nanotechnology-based theranostic (diagnostic + therapeutic) technology that will facilitate non-invasive imaging, and at the ..
- Nanotechnology Enabled Temporomandibular Joint (TMJ) ProsthesisRAYMOND G THOMPSON; Fiscal Year: 2010..Our specific aims are as follows: Specific Aim 1: Develop nanotechnology for reducing friction and wear on the articulating, load-bearing components of TMJ metallic implants (condyle ..
- Optimization of SWCNT/siRNA complex formulation for tumor accumulationLynn Kirkpatrick; Fiscal Year: 2012..is a biotechnology company located in Houston, TX, exploiting the pionering nanotechnology studies of the late 1996 Nobel Laureate, Dr. Richard Smalley of Rice University. The rights to Dr...
- RNA Nanomotor Based Active Devices for Biology and MedicineRashid Bashir; Fiscal Year: 2009DESCRIPTION (provided by applicant): Nanotechnology is truly revolutionizing our ability to manufacture and design active devices and systems that are small, cheap, and ultra-sensitive...
- Catalytic DNA Biosensor for Toxic Metal IonsYi Lu; Fiscal Year: 2009..of state-of-the-art tools in catalytic DNA biology, catalytic molecular beacons biotechnology and nanoparticle nanotechnology. Catalytic DNA molecules specific for heavy metal ions will be obtained through in vitro selection, and ..
- Dual Antigen Nanoparticle Vaccine System For Bacillus Infectious DiseasePuthupparampil Scaria; Fiscal Year: 2009Development of rationally designed vaccines is an important need that nanotechnology has tremendous potential to transform. Already nanoparticle developments are incorporated into approved small molecule therapeutics...
- DNA-modulated release of drug from melanoma targeting NPKit Lam; Fiscal Year: 2009..b>Nanotechnology is an emerging field that has shown promise for the development of novel diagnostic, imaging and therapeutic ..
- Shape Specific, Enzyme-Responsive, Nano-Imprinted Particles for Drug DeliveryKrishnendu Roy; Fiscal Year: 2009b>Nanotechnology is one of the most promising avenues for the development of advanced drug delivery vehicles. Classically, the field has focused on synthesizing nanocarriers based on self assembly or emulsion based concepts...
- A Nanotechnology Enabled Point of Care Diagnostic Platform for Early Stage CancerJames Nelson; Fiscal Year: 2009..We propose to develop a nanotechnology enabled protein signature based diagnostic test for prostate cancer available at the point of primary care.
- Nanotechnology for One Step Concentration and Preservation of Labile Biomarkers iLANCE ALLEN LIOTTA; Fiscal Year: 2010..This project will deliver a novel nanotechnology that can rapidly harvest, concentrate, and protect from degradation, labile biomarkers in whole blood or serum,..
- Enhancing Faculty Recruitment in Nanoscale Sciences for Biomedical ResearchYogesh K Vohra; Fiscal Year: 2010..and health professions, the Center is uniquely positioned to be at the forefront of biomaterials research and nanotechnology development for improving human health...
- Novel Cancer Nanotechnology Platforms for Photodynamic Therapy and ImagingRavindra Pandey; Fiscal Year: 2009..Paras Prasad, PhD (UB), will lead development and photophysical characterization of the Ormosil platform. Raoul Kopelman, PhD (UM), will lead development and photophysical characterization the polyacrylamide platform. ..