nanotechnology

Summary

Summary: The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.

Top Publications

  1. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
  2. ncbi Understanding biophysicochemical interactions at the nano-bio interface
    Andre E Nel
    Division of NanoMedicine, David Geffen School of Medicine and California NanoSystems Institute at UCLA, Los Angeles, California 90095, USA
    Nat Mater 8:543-57. 2009
  3. ncbi Folding DNA to create nanoscale shapes and patterns
    Paul W K Rothemund
    Departments of Computer Science and Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA
    Nature 440:297-302. 2006
  4. ncbi Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology
    Marie Christine Daniel
    Molecular Nanosciences and Catalysis Group, LCOO, UMR CNRS No 5802, Universite Bordeaux I, 33405 Talence Cedex, France
    Chem Rev 104:293-346. 2004
  5. ncbi Drug delivery systems: entering the mainstream
    Theresa M Allen
    Department of Pharmacology, University of Alberta, Edmonton T6G 2H7, Canada
    Science 303:1818-22. 2004
  6. ncbi Effect of surface properties on nanoparticle-cell interactions
    Ayush Verma
    Department of Materials Science and Engineering, Massachusetts Institute of Technology MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Small 6:12-21. 2010
  7. ncbi The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder
    Matthew J Dalby
    Centre for Cell Engineering, Joseph Black Building, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK
    Nat Mater 6:997-1003. 2007
  8. pmc Stem cell fate dictated solely by altered nanotube dimension
    Seunghan Oh
    Department of Materials Science and Engineering, University California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:2130-5. 2009
  9. pmc Challenges and opportunities for structural DNA nanotechnology
    Andre V Pinheiro
    Center for Single Molecule Biophysics, The Biodesign Institute, Arizona State University, Tempe, USA
    Nat Nanotechnol 6:763-72. 2011
  10. ncbi WSXM: a software for scanning probe microscopy and a tool for nanotechnology
    I Horcas
    Nanotec Electrónica S L, Centro Empresarial Euronova 3, Ronda de Poniente 2, Edificio 2 1a Planta Oficina A, 28760 Tres Cantos, E 28049 Madrid, Spain
    Rev Sci Instrum 78:013705. 2007

Detail Information

Publications376 found, 100 shown here

  1. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
    ..The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable...
  2. ncbi Understanding biophysicochemical interactions at the nano-bio interface
    Andre E Nel
    Division of NanoMedicine, David Geffen School of Medicine and California NanoSystems Institute at UCLA, Los Angeles, California 90095, USA
    Nat Mater 8:543-57. 2009
    Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment...
  3. ncbi Folding DNA to create nanoscale shapes and patterns
    Paul W K Rothemund
    Departments of Computer Science and Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA
    Nature 440:297-302. 2006
    ..Finally, individual DNA structures can be programmed to form larger assemblies, including extended periodic lattices and a hexamer of triangles (which constitutes a 30-megadalton molecular complex)...
  4. ncbi Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology
    Marie Christine Daniel
    Molecular Nanosciences and Catalysis Group, LCOO, UMR CNRS No 5802, Universite Bordeaux I, 33405 Talence Cedex, France
    Chem Rev 104:293-346. 2004
  5. ncbi Drug delivery systems: entering the mainstream
    Theresa M Allen
    Department of Pharmacology, University of Alberta, Edmonton T6G 2H7, Canada
    Science 303:1818-22. 2004
    ..Furthermore, there is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics...
  6. ncbi Effect of surface properties on nanoparticle-cell interactions
    Ayush Verma
    Department of Materials Science and Engineering, Massachusetts Institute of Technology MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Small 6:12-21. 2010
    ..Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed...
  7. ncbi The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder
    Matthew J Dalby
    Centre for Cell Engineering, Joseph Black Building, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK
    Nat Mater 6:997-1003. 2007
    ..In addition, the current studies show that topographically treated MSCs have a distinct differentiation profile compared with those treated with osteogenic media, which has implications for cell therapies...
  8. pmc Stem cell fate dictated solely by altered nanotube dimension
    Seunghan Oh
    Department of Materials Science and Engineering, University California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:2130-5. 2009
    ..cell elongation (approximately 10-fold increased), which induced cytoskeletal stress and selective differentiation into osteoblast-like cells, offering a promising nanotechnology-based route for unique orthopedics-related hMSC treatments.
  9. pmc Challenges and opportunities for structural DNA nanotechnology
    Andre V Pinheiro
    Center for Single Molecule Biophysics, The Biodesign Institute, Arizona State University, Tempe, USA
    Nat Nanotechnol 6:763-72. 2011
    ..Here we examine the technical challenges in the field of structural DNA nanotechnology and outline some of the promising applications that could be developed if these hurdles can be overcome...
  10. ncbi WSXM: a software for scanning probe microscopy and a tool for nanotechnology
    I Horcas
    Nanotec Electrónica S L, Centro Empresarial Euronova 3, Ronda de Poniente 2, Edificio 2 1a Planta Oficina A, 28760 Tres Cantos, E 28049 Madrid, Spain
    Rev Sci Instrum 78:013705. 2007
    ..Finally, a detailed discussion of some relevant procedures of the software is carried out...
  11. ncbi Cancer nanotechnology: opportunities and challenges
    Mauro Ferrari
    Division of Haematology and Oncology, 110U Davis Heart and Lung Research Institute, The Ohio State University, 473 West 12th Avenue, Columbus OH 43210 1002, USA
    Nat Rev Cancer 5:161-71. 2005
    b>Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices derived from engineering, biology, physics and chemistry...
  12. pmc Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
    L R Hirsch
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, TX 77251 1892, USA
    Proc Natl Acad Sci U S A 100:13549-54. 2003
    ..Tissues heated above the thermal damage threshold displayed coagulation, cell shrinkage, and loss of nuclear staining, which are indicators of irreversible thermal damage. Control tissues appeared undamaged...
  13. ncbi Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots
    Xingyong Wu
    Quantum Dot Corporation, 26118 Research Rd, Hayward, CA 94545, USA
    Nat Biotechnol 21:41-6. 2003
    ..The results indicate that QD-based probes can be very effective in cellular imaging and offer substantial advantages over organic dyes in multiplex target detection...
  14. ncbi Impact of nanotechnology on drug delivery
    Omid C Farokhzad
    Laboratory of Nanomedicine and Biomaterials and Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    ACS Nano 3:16-20. 2009
    b>Nanotechnology is the engineering and manufacturing of materials at the atomic and molecular scale...
  15. pmc Self-assembly of DNA into nanoscale three-dimensional shapes
    Shawn M Douglas
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 459:414-8. 2009
    ..We anticipate that our strategy for self-assembling custom three-dimensional shapes will provide a general route to the manufacture of sophisticated devices bearing features on the nanometre scale...
  16. ncbi Self-assembly at all scales
    George M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Science 295:2418-21. 2002
    ..The concept of self-assembly is used increasingly in many disciplines, with a different flavor and emphasis in each...
  17. ncbi Dynamic DNA nanotechnology using strand-displacement reactions
    David Yu Zhang
    Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, Room 530, Boston, Massachussetts 02115, USA
    Nat Chem 3:103-13. 2011
    ..Although it had initially focused on the self-assembly of static structures, DNA nanotechnology is now also becoming increasingly attractive for engineering systems with interesting dynamic properties...
  18. pmc Nanotechnology in drug delivery and tissue engineering: from discovery to applications
    Jinjun Shi
    MIT Harvard Center for Cancer Nanotechnology Excellence, Laboratory of Nanomedicine and Biomaterials, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nano Lett 10:3223-30. 2010
    The application of nanotechnology in medicine, referred to as nanomedicine, is offering numerous exciting possibilities in healthcare...
  19. ncbi Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology
    G Oberdorster
    Department of Environmental Medicine, University of Rochester, 601 Elmwood Avenue, Medical Center, Rochester, NY 14642, USA
    J Intern Med 267:89-105. 2010
    b>Nanotechnology, nanomedicine and nanotoxicology are complementary disciplines aimed at the betterment of human life...
  20. ncbi Exploring and engineering the cell surface interface
    Molly M Stevens
    Department of Materials and Institute for Biomedical Engineering, Imperial College of Science, Technology, and Medicine, Prince Consort Road, London SW7 2BP, UK
    Science 310:1135-8. 2005
    ..Far-reaching implications are emerging for applications including medical implants, cell supports, and materials that can be used as instructive three-dimensional environments for tissue regeneration...
  21. pmc Antimicrobial applications of nanotechnology: methods and literature
    Justin T Seil
    Laboratory for Nanomedicine Research, School of Engineering, Brown University, Providence, RI 02917, USA
    Int J Nanomedicine 7:2767-81. 2012
    ..Consequently, new methods for reducing bacteria activity (and associated infections) are badly needed. Nanotechnology, the use of materials with dimensions on the atomic or molecular scale, has become increasingly utilized for ..
  22. ncbi Direct multiplexed measurement of gene expression with color-coded probe pairs
    Gary K Geiss
    NanoString Technologies Inc, 201 Elliott Ave West, Suite 300, Seattle, Washington 98119, USA
    Nat Biotechnol 26:317-25. 2008
    ..Finally, a comparison of transcript levels for 21 genes across seven samples measured by the nCounter system and SYBR Green real-time PCR demonstrated similar patterns of gene expression at all transcript levels...
  23. ncbi Safe handling of nanotechnology
    Andrew D Maynard
    Woodrow Wilson International Center for Scholars, USA
    Nature 444:267-9. 2006
  24. ncbi DNA in a material world
    Nadrian C Seeman
    Department of Chemistry, New York University, New York 10003, USA
    Nature 421:427-31. 2003
    ..This powerful molecular recognition system can be used in nanotechnology to direct the assembly of highly structured materials with specific nanoscale features, as well as in DNA ..
  25. pmc Current advances in research and clinical applications of PLGA-based nanotechnology
    Jian ming Lu
    Michael E DeBakey Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Expert Rev Mol Diagn 9:325-41. 2009
    Co-polymer poly(lactic-co-glycolic acid) (PLGA) nanotechnology has been developed for many years and has been approved by the US FDA for the use of drug delivery, diagnostics and other applications of clinical and basic science research, ..
  26. ncbi Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins
    Jwa Min Nam
    Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60201, USA
    Science 301:1884-6. 2003
    ..Comparable clinically accepted conventional assays for detecting the same target have sensitivity limits of approximately 3 picomdar, six orders of magnitude less sensitive than what is observed with this method...
  27. ncbi Nanoparticle and targeted systems for cancer therapy
    Lisa Brannon-Peppas
    Department of Biomedical Engineering, The University of Texas at Austin, 1 University Station, C0800, Austin, TX 78712 0231, USA
    Adv Drug Deliv Rev 56:1649-59. 2004
    ..Delivery methods that specifically use nanoparticles are also highlighted, including both degradable and nondegradable polymers...
  28. ncbi The use of nanocrystals in biological detection
    Paul Alivisatos
    University of California Berkeley, Department of Chemistry, B60 Hildebrand Hall, Berkeley, California 94720 1460, USA
    Nat Biotechnol 22:47-52. 2004
    ....
  29. ncbi Continuous base identification for single-molecule nanopore DNA sequencing
    James Clarke
    Oxford Nanopore Technologies Ltd, Begbroke Science Park, Sandy Lane, Oxford OX5 1PF, UK
    Nat Nanotechnol 4:265-70. 2009
    ..This highly accurate tool is suitable for integration into a system for sequencing nucleic acids and for analysing epigenetic modifications...
  30. ncbi Activation of integrin function by nanopatterned adhesive interfaces
    Marco Arnold
    University of Heidelberg, Institute for Physical Chemistry, Biophysical Chemistry, INF 253, 69120 Heidelberg, Germany
    Chemphyschem 5:383-8. 2004
    ..We propose that the range between 58-73 nm is a universal length scale for integrin clustering and activation, since these properties are shared by a variety of cultured cells...
  31. ncbi Exosome nanotechnology: an emerging paradigm shift in drug delivery: exploitation of exosome nanovesicles for systemic in vivo delivery of RNAi heralds new horizons for drug delivery across biological barriers
    Samira Lakhal
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Bioessays 33:737-41. 2011
    ....
  32. pmc Bioconjugated quantum dots for in vivo molecular and cellular imaging
    Andrew M Smith
    Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA
    Adv Drug Deliv Rev 60:1226-40. 2008
    ..We also examine key issues for in vivo imaging and therapy, such as nanoparticle biodistribution, pharmacokinetics, and toxicology...
  33. ncbi Nanomedicine: current status and future prospects
    S Moein Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, UK
    FASEB J 19:311-30. 2005
    Applications of nanotechnology for treatment, diagnosis, monitoring, and control of biological systems has recently been referred to as "nanomedicine" by the National Institutes of Health...
  34. ncbi Self-assembled monolayers of thiolates on metals as a form of nanotechnology
    J Christopher Love
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Chem Rev 105:1103-69. 2005
  35. ncbi Electrospinning of collagen nanofibers
    Jamil A Matthews
    Department of Physiology, Virginia Commonwealth University, Richmond, Virginia 23298 0551, USA
    Biomacromolecules 3:232-8. 2002
    ..The structural, material, and biological properties of electrospun collagen suggest that this material may represent a nearly ideal tissue engineering scaffold...
  36. pmc The emerging field of RNA nanotechnology
    Peixuan Guo
    Nanobiomedical Center, College of Engineering and College of Medicine, University of Cincinnati, Cincinnati, Ohio 45221, USA
    Nat Nanotechnol 5:833-42. 2010
    ..Although RNA nanotechnology resembles DNA nanotechnology in many ways, the base-pairing rules for constructing nanoparticles are different...
  37. ncbi Neural network computation with DNA strand displacement cascades
    Lulu Qian
    Bioengineering, California Institute of Technology, Pasadena, California 91125, USA
    Nature 475:368-72. 2011
    ..Our results suggest that DNA strand displacement cascades could be used to endow autonomous chemical systems with the capability of recognizing patterns of molecular events, making decisions and responding to the environment...
  38. ncbi Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
    Mukesh G Harisinghani
    Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 348:2491-9. 2003
    ....
  39. ncbi Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging
    Jae Hyun Lee
    Department of Chemistry and Nanomedical National Core Research Center, Yonsei University, Seoul 120 749, Korea
    Nat Med 13:95-9. 2007
    ..Also, we successfully visualized small tumors implanted in a mouse. Such high-performance, nanotechnology-based molecular probes could enhance the ability to visualize other biological events critical to diagnostics ..
  40. ncbi DNA-assisted dispersion and separation of carbon nanotubes
    Ming Zheng
    DuPont Central Research and Development, Experimental Station, Wilmington, Delaware 19880, USA
    Nat Mater 2:338-42. 2003
    ..This finding links one of the central molecules in biology to a technologically very important nanomaterial, and opens the door to carbon-nanotube-based applications in biotechnology...
  41. ncbi In vitro toxicity of silver nanoparticles at noncytotoxic doses to HepG2 human hepatoma cells
    Koji Kawata
    Department of Urban and Environmental Engineering, Graduate School of Engineering, Hokkaido University, North 13, West 8, Kita ku, Sapporo 060 8628, Japan
    Environ Sci Technol 43:6046-51. 2009
    ..Based on these discussions, it is concluded that both "nanosized particle of Ag" as well as "ionic Ag+" contribute to the toxic effects of Ag-NPs...
  42. pmc Molecular robots guided by prescriptive landscapes
    Kyle Lund
    Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287, USA
    Nature 465:206-10. 2010
    ....
  43. ncbi Application of nanotechnology in cancer therapy and imaging
    Xu Wang
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
    CA Cancer J Clin 58:97-110. 2008
    Recent developments in nanotechnology have provided researchers with new tools for cancer imaging and treatment...
  44. pmc Progress in antiretroviral drug delivery using nanotechnology
    Rama Mallipeddi
    University of Pittsburgh, Department of Pharmaceutical Sciences, School of Pharmacy, Magee Womens Research Institute, Pittsburgh, PA, USA
    Int J Nanomedicine 5:533-47. 2010
    ..Their application in the area of HIV prevention and therapy may lead to the development of more effective drug products for combating this pandemic disease...
  45. ncbi Typing Chlamydia trachomatis: from egg yolk to nanotechnology
    Lisbeth Nørum Pedersen
    Department of Clinical Microbiology, Aarhus University Hospital, Skejby, Denmark
    FEMS Immunol Med Microbiol 55:120-30. 2009
    ..The futuristic nanotechnology already seems at hand to further simplify and automate the high-resolution genotyping method based on NAAT and ..
  46. ncbi An application of nanotechnology in advanced dental materials
    Sumita B Mitra
    3M ESPE Dental Products, St Paul, Minn 55144, USA
    J Am Dent Assoc 134:1382-90. 2003
    ..This article reports the authors' development of nanofillers and a resulting nanocomposite. They measured the nanocomposite's properties in vitro in comparison with those of several existing composites (hybrids, microhybrids and microfill)...
  47. pmc Magnetic tweezers: micromanipulation and force measurement at the molecular level
    Charlie Gosse
    Laboratoire de Physique Statistique, Ecole Normale Superieure, Unité de Recherche 8550 associée au Centre National de la Recherche Scientifique et aux Universités Paris VI et VII, 75231 Paris, France
    Biophys J 82:3314-29. 2002
    ..From those experiments, we conclude that magnetic tweezers represent a low-cost and biocompatible setup that could become a suitable alternative to the other available micromanipulators...
  48. ncbi Soft lithography for micro- and nanoscale patterning
    Dong Qin
    Nano Research Facility and Department of Energy, Environmental, and Chemical Engineering, Washington University, St Louis, Missouri, USA
    Nat Protoc 5:491-502. 2010
    ....
  49. pmc Reducing infections through nanotechnology and nanoparticles
    Erik Taylor
    School of Engineering, Brown University, Providence, RI 02917, USA
    Int J Nanomedicine 6:1463-73. 2011
    ..review article will first examine in detail the mechanisms and applications of some of these nanoparticles, then follow with some recent material designs utilizing nanotechnology that are centered on fighting medical device infections.
  50. pmc Folding DNA into twisted and curved nanoscale shapes
    Hendrik Dietz
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Science 325:725-30. 2009
    ..We also combined multiple curved elements to build several different types of intricate nanostructures, such as a wireframe beach ball or square-toothed gears...
  51. ncbi Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles
    J F Hillyer
    Department of Animal Health and Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 1656 Linden Drive, Madison, Wisconsin 53706, USA
    J Pharm Sci 90:1927-36. 2001
    ..To our knowledge this is the first report, at the ultrastructural level, of gastrointestinal uptake of particulates by persorption through holes created by extruding enterocytes...
  52. pmc Lipid-based nanoparticles as pharmaceutical drug carriers: from concepts to clinic
    Anu Puri
    Center for Cancer Research Nanobiology Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702 1201, USA
    Crit Rev Ther Drug Carrier Syst 26:523-80. 2009
    In recent years, various nanotechnology platforms in the area of medical biology, including both diagnostics and therapy, have gained remarkable attention...
  53. ncbi Filamentous bacteriophage: biology, phage display and nanotechnology applications
    Jasna Rakonjac
    Institute of Molecular Biosciences, Massey University, Palmerston North, New Zealand
    Curr Issues Mol Biol 13:51-76. 2011
    ..In the first half of the review, both the Ff and temperate phage are described and compared. A large section of the review is devoted to an overview of phage display technology and its applications in nanotechnology.
  54. pmc Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles
    Shanta Dhar
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:17356-61. 2008
    ..The effectiveness of PSMA targeted Pt-NP-Apt nanoparticles against the PSMA(+) LNCaP cells is approximately an order of magnitude greater than that of free cisplatin...
  55. ncbi DNA nanomachines
    Jonathan Bath
    University of Oxford, Department of Physics, Clarendon Laboratory, Parks Road, Oxford OX1 3PU, UK
    Nat Nanotechnol 2:275-84. 2007
    ..It has even proved possible to create DNA motors that move autonomously, obtaining energy by catalysing the reaction of DNA or RNA fuels...
  56. ncbi Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection
    YunWei Charles Cao
    Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Science 297:1536-40. 2002
    ..Six dissimilar DNA targets with six Raman-labeled nanoparticle probes were distinguished, as well as two RNA targets with single nucleotide polymorphisms. The current unoptimized detection limit of this method is 20 femtomolar...
  57. pmc Nanoparticle interaction with biological membranes: does nanotechnology present a Janus face?
    Pascale R Leroueil
    Program in Macromolecular Science and Engineering, Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    Acc Chem Res 40:335-42. 2007
    ....
  58. ncbi Electrospun nanofibrous structure: a novel scaffold for tissue engineering
    Wan Ju Li
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, USA
    J Biomed Mater Res 60:613-21. 2002
    ..This novel biodegradable scaffold has potential applications for tissue engineering based upon its unique architecture, which acts to support and guide cell growth...
  59. ncbi New approaches to nanofabrication: molding, printing, and other techniques
    Byron D Gates
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Chem Rev 105:1171-96. 2005
  60. ncbi Electrochemical DNA sensors
    T Gregory Drummond
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Nat Biotechnol 21:1192-9. 2003
    ....
  61. ncbi Role of nanotechnology in pharmaceutical product development
    Harikrishna Devalapally
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 110 Mugar Life Sciences Building, Boston, Massachusetts 02115, USA
    J Pharm Sci 96:2547-65. 2007
    ..This review summarizes some of the parameters and approaches that can be used to evaluate nanoparticulate drug delivery systems in early stages of formulation development...
  62. ncbi A robust DNA mechanical device controlled by hybridization topology
    Hao Yan
    Department of Chemistry, New York University, New York, NY 10003, USA
    Nature 415:62-5. 2002
    ..We expect that a wide range of analogous yet distinct rotary devices can be created by changing the control strands and the device sequences to which they bind...
  63. ncbi The University of California Center for the Environmental Implications of Nanotechnology
    Hilary A Godwin
    University of California, School of Public Health, Los Angeles, CA, USA
    Environ Sci Technol 43:6453-7. 2009
    ..Assessing nanomaterialsfor human health and ecotoxicological impact can be well aided by using high-throughput laboratory methods...
  64. ncbi Live-cell photoactivated localization microscopy of nanoscale adhesion dynamics
    Hari Shroff
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, USA
    Nat Methods 5:417-23. 2008
    ..By allowing observation of a wide variety of nanoscale dynamics, live-cell PALM provides insights into molecular assembly during the initiation, maturation and dissolution of cellular processes...
  65. pmc Graphene as a subnanometre trans-electrode membrane
    S Garaj
    Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 467:190-3. 2010
    ..The sensitivity of graphene's in-plane electronic conductivity to its immediate surface environment and trans-membrane solution potentials will offer new insights into atomic surface processes and sensor development opportunities...
  66. ncbi Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery
    Rajni Sinha
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, Room 3090, Atlanta, GA 30322, USA
    Mol Cancer Ther 5:1909-17. 2006
    b>Nanotechnology refers to the interactions of cellular and molecular components and engineered materials-typically, clusters of atoms, molecules, and molecular fragments into incredibly small particles-between 1 and 100 nm...
  67. ncbi DNA origami with complex curvatures in three-dimensional space
    Dongran Han
    The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
    Science 332:342-6. 2011
    ..A series of DNA nanostructures with high curvature--such as 2D arrangements of concentric rings and 3D spherical shells, ellipsoidal shells, and a nanoflask--were assembled...
  68. ncbi Electrospun P(LLA-CL) nanofiber: a biomimetic extracellular matrix for smooth muscle cell and endothelial cell proliferation
    X M Mo
    Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, 117576, Singapore, Singapore
    Biomaterials 25:1883-90. 2004
    ..The biocompatibility of the nanofiber scaffold has been investigated by culturing cells on the nanofiber scaffold. Both smooth muscle cell and endothelial cell adhered and proliferated well on the P(LLA-CL) nanofiber scaffolds...
  69. ncbi Programmable nanowire circuits for nanoprocessors
    Hao Yan
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 470:240-4. 2011
    ....
  70. pmc A bipedal DNA Brownian motor with coordinated legs
    Tosan Omabegho
    School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
    Science 324:67-71. 2009
    ..This device should be able to fulfill roles that entail the performance of useful mechanical work on the nanometer scale...
  71. ncbi Towards the application of cytoskeletal motor proteins in molecular detection and diagnostic devices
    Till Korten
    Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany
    Curr Opin Biotechnol 21:477-88. 2010
    ..This opens up the opportunity to design highly integrated, miniaturized, autonomous detection devices. Such devices, in turn, may allow fast and cheap on-site diagnosis of diseases and detection of environmental pathogens and toxins...
  72. ncbi Selective differentiation of neural progenitor cells by high-epitope density nanofibers
    Gabriel A Silva
    Institute for Bioengineering and Nanoscience in Advanced Medicine, Northwestern University, Chicago, IL 60611, USA
    Science 303:1352-5. 2004
    ..This rapid selective differentiation is linked to the amplification of bioactive epitope presentation to cells by the nanofibers...
  73. ncbi Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery
    Jayanth Panyam
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    FASEB J 16:1217-26. 2002
    ..S. Food and Drug Administration. Hence PLGA is well suited for sustained intracellular delivery of macromolecules...
  74. ncbi Actin filament guidance on a chip: toward high-throughput assays and lab-on-a-chip applications
    Mark Sundberg
    Department of Chemistry and Biomedical Sciences, University of Kalmar, SE 39182 Kalmar, Sweden
    Langmuir 22:7286-95. 2006
    ..The results are discussed in relation to lab-on-a-chip applications and nanotechnology-assisted assays of actomyosin function.
  75. ncbi Imaging intracellular fluorescent proteins at nanometer resolution
    Eric Betzig
    Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA 20147, USA
    Science 313:1642-5. 2006
    ....
  76. pmc Types of neural guides and using nanotechnology for peripheral nerve reconstruction
    Esmaeil Biazar
    Department of Chemistry, Islamic Azad University Tonekabon Branch, Iran
    Int J Nanomedicine 5:839-52. 2010
    ..types of artificial and natural guides, and methods to improve the performance of tubes, such as orientation, nanotechnology applications for nerve reconstruction, fibers and nanofibers, electrospinning methods, and their application ..
  77. ncbi Pharmaceutical nanotechnology for oral delivery of anticancer drugs
    Lin Mei
    Division of Life and Health Sciences, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
    Adv Drug Deliv Rev 65:880-90. 2013
    ..Pharmaceutical nanotechnology, which is to apply and further develop nanotechnology to solve the problems in drug delivery, may provide a ..
  78. pmc Cellular nanotechnology: making biological interfaces smarter
    Paula M Mendes
    School of Chemical Engineering, University of Birmingham, Birmingham, B15 2TT, UK
    Chem Soc Rev 42:9207-18. 2013
    Recently, there has been an outburst of research on engineered cell-material interfaces driven by nanotechnology and its tools and techniques...
  79. ncbi Inception to actualization: next generation coronary stent coatings incorporating nanotechnology
    Aaron Tan
    Centre for Nanotechnology and Regenerative Medicine, UCL Division of Surgery and Interventional Science, University College London UCL, London NW3 2QG, UK
    J Biotechnol 164:151-70. 2013
    ..The advent of nanotechnology has engendered techniques like layer-by-layer self-assembly, and localized drug and gene delivery using ..
  80. pmc Nanoparticles and the immune system
    Banu S Zolnik
    Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Food and Drug Administration, Silver Spring, Maryland 20993, USA
    Endocrinology 151:458-65. 2010
    Today nanotechnology is finding growing applications in industry, biology, and medicine...
  81. ncbi Nanotechnology: convergence with modern biology and medicine
    Mihail C Roco
    National Science Foundation, Room 505, 4201 Wilson Blvd, Arlington, VA 22230, USA
    Curr Opin Biotechnol 14:337-46. 2003
    The worldwide emergence of nanoscale science and engineering was marked by the announcement of the National Nanotechnology Initiative (NNI) in January 2000...
  82. ncbi Solid-state nanopores
    Cees Dekker
    Kavli Institute of Nanoscience, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands
    Nat Nanotechnol 2:209-15. 2007
    ..The solid-state nanopore proves to be a surprisingly versatile new single-molecule tool for biophysics and biotechnology...
  83. pmc The complex role of multivalency in nanoparticles targeting the transferrin receptor for cancer therapies
    Jin Wang
    Departments of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA
    J Am Chem Soc 132:11306-13. 2010
    ....
  84. ncbi Cancer nanotechnology: application of nanotechnology in cancer therapy
    Ranjita Misra
    Institute of Life Sciences, Chandrasekharpur, Bhubaneswar, Orissa, India
    Drug Discov Today 15:842-50. 2010
    The application of nanotechnology for cancer therapy has received considerable attention in recent years...
  85. ncbi Graphene/AuNPs/chitosan nanocomposites film for glucose biosensing
    Changsheng Shan
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Graduate University of the Chinese Academy of Sciences, Changchun, PR China
    Biosens Bioelectron 25:1070-4. 2010
    ..The graphene/AuNPs/GOD/chitosan composites film shows prominent electrochemical response to glucose, which makes a promising application for electrochemical detection of glucose...
  86. ncbi Efficacy of transferrin-conjugated paclitaxel-loaded nanoparticles in a murine model of prostate cancer
    Sanjeeb K Sahoo
    Department of Pharmaceutical Sciences, Nebraska Medical Center, Omaha, NE 68198 6025, USA
    Int J Cancer 112:335-40. 2004
    ..In conclusion, sustained release NPs demonstrated greater antitumor activity following their conjugation to Tf ligand...
  87. ncbi Silanized surfaces for in vitro studies of actomyosin function and nanotechnology applications
    Mark Sundberg
    Department of Chemistry and Biomedical Sciences, University of Kalmar, SE 391 82 Kalmar, Sweden
    Anal Biochem 323:127-38. 2003
    ..Furthermore, TMCS derivatized glass also seems to offer several advantages over nitrocellulose for HMM adsorption in the ordinary in vitro motility assay...
  88. ncbi Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineering
    C Y Xu
    Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, 117576 Singapore, Singapore
    Biomaterials 25:877-86. 2004
    ....
  89. ncbi Actin-based metallic nanowires as bio-nanotransporters
    Fernando Patolsky
    Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Nat Mater 3:692-5. 2004
    ..These actin-based metallic wires and their nanotransporting funcionality introduce new concepts for developing biological/inorganic hybrid devices...
  90. ncbi DNA as supramolecular scaffold for functional molecules: progress in DNA nanotechnology
    Thomas J Bandy
    University of Southampton, School of Chemistry, Highfield, Southampton SO17 1BJ, UK
    Chem Soc Rev 40:138-48. 2011
    ..Using selected examples of the recent literature, the diversity of the functionalities that have been incorporated into DNA strands is discussed...
  91. ncbi Nanoparticles of biodegradable polymers for clinical administration of paclitaxel
    Si Shen Feng
    Division of Bioengineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    Curr Med Chem 11:413-24. 2004
    ....
  92. pmc Label-free biomarker detection from whole blood
    Eric Stern
    Department of Biomedical Engineering, School of Engineering and Applied Science, Yale University, New Haven, Connecticut 06511, USA
    Nat Nanotechnol 5:138-42. 2010
    ..This study marks the first use of label-free nanosensors with physiological solutions, positioning this technology for rapid translation to clinical settings...
  93. ncbi Ten years of tension: single-molecule DNA mechanics
    Carlos Bustamante
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nature 421:423-7. 2003
    ..These studies have illuminated the nature of interactions between DNA and proteins, the constraints within which the cellular machinery operates, and the forces created by DNA-dependent motors...
  94. ncbi Dendrimers in biomedical applications--reflections on the field
    Sonke Svenson
    Dendritic NanoTechnologies, Inc, 2625 Denison Drive, Mount Pleasant, MI 48858, USA
    Adv Drug Deliv Rev 57:2106-29. 2005
    ..The reflections on biomedical applications of dendrimers given in this review clearly demonstrate the potential of this new fourth major class of polymer architecture and indeed substantiate the high hopes for the future of dendrimers...
  95. ncbi Nanotechnology and HIV: potential applications for treatment and prevention
    Peter S Kim
    Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 2:693-702. 2010
    ..The capabilities inherent to nanotechnology hold much potential for impact in the field of HIV treatment and prevention...
  96. pmc Emerging nanotechnology approaches for HIV/AIDS treatment and prevention
    Tewodros Mamo
    Laboratory of Nanomedicine and Biomaterials, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Nanomedicine (Lond) 5:269-85. 2010
    ..b>Nanotechnology is an emerging multidisciplinary field that is revolutionizing medicine in the 21st century...
  97. ncbi From nanotechnology to nanomedicine: applications to cancer research
    R Seigneuric
    Département Nanosciences, Laboratoire Interdisciplinaire Carnot de Bourgogne, CNRS UMR 5209, 9, Avenue Alain Savary, BP 47870, 21078 Dijon Cedex, France
    Curr Mol Med 10:640-52. 2010
    ..This translational review aims at integrating some recent advances from micro- and nano-technologies with high potential for improving daily oncology practice...
  98. ncbi Directed self-assembly of nanoparticles
    Marek Grzelczak
    Departamento de Quimica Fisica and Unidad Asociada CSIC Universidade de Vigo, 36310 Vigo, Spain
    ACS Nano 4:3591-605. 2010
    Within the field of nanotechnology, nanoparticles are one of the most prominent and promising candidates for technological applications...
  99. ncbi Nanotechnology applied to the treatment of malaria
    Nereide Stela Santos-Magalhães
    Laboratório de Imunopatologia Keizo Asami LIKA, Universidade Federal de Pernambuco UFPE, Recife, PE, Brazil
    Adv Drug Deliv Rev 62:560-75. 2010
    ..This review emphasizes the main requirements for developing new nanotechnology-based carriers as a promising choice in malaria treatment, especially in the case of severe cerebral malaria.
  100. pmc Single-nucleotide discrimination in immobilized DNA oligonucleotides with a biological nanopore
    David Stoddart
    Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom
    Proc Natl Acad Sci U S A 106:7702-7. 2009
    ..The additional steps required to enable nanopore DNA sequencing are outlined...
  101. ncbi Electrospinning of polymeric nanofibers for tissue engineering applications: a review
    Quynh P Pham
    Department of Bioengineering, Rice University, Houston, Texas 77251 1892, USA
    Tissue Eng 12:1197-211. 2006
    ....

Research Grants73

  1. Hybrid Nanoparticles in Imaging and Therapy of Prostate*
    Kattesh Katti; Fiscal Year: 2009
    The University of Missouri (MU) Cancer Nanotechnology Platform (CNP) is the culmination of long-standing interdisciplinary partnerships in departments within the School of Medicine, the College of Arts and Science, the College of ..
  2. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  3. Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseases
    Robert M Weiss; Fiscal Year: 2010
    ..Our first test of these nanoparticles will use a mouse model of bladder cancer. Thus, we can determine the therapeutic potential of siRNA for treatment of urologic diseases. ..
  4. Nanopolymersomes for Transcutaneous Co-Delivery of Vaccine Antigens and Adjuvants
    PAUL CAMILLE TUMEH; Fiscal Year: 2013
    ..plan is to become an independent physician-scientist investigator focused on the synthesis and utilization of nanotechnology systems for needle-free transcutaneous immunotherapeutics...
  5. Alzheimer's Disease Therapeutic
    Trevor P Castor; Fiscal Year: 2012
    ..hydrophobic molecules such as bryostatin 1 in stable, readily bioavailable oil-based formulations, and novel nanotechnology formulations of bryostatin 1 that will further improve oral bioavailability...
  6. Nanoemulsion-based vaccine for chronic hepatitis B virus
    James R Baker; Fiscal Year: 2010
    ..NanoBio Corporation (Ann Arbor, MI) and the University of Michigan, Michigan Nanotechnology Institute for Medicine and Biological Sciences are developing a nanoemulsion (NE) based adjuvant to enhance ..
  7. Brain Delivery of Nanoformulated Superoxide Dismutase
    Erin G Rosenbaugh; Fiscal Year: 2013
    ..In addition to the proposed scientific research, this fellowship will support the applicant's participation in nanotechnology-based coursework and career development.
  8. Theranostic Nanomedicine for Breast Cancer Prevention and Image-Guided Therapy
    Prakash R Rai; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): This proposal uses a nanotechnology and optical imaging-based strategy for prevention (AIM 1) and image-guided treatment (Aim 2) of breast cancer (BrCa) by targeting several key molecular targets in ..
  9. Detection of engineered nanomaterials in drinking water, food, commercial product
    Paul K Westerhoff; Fiscal Year: 2010
    b>Nanotechnology is rapidly resulting in the production of nanomaterials (NMs) that will be used in everything from toothpaste to pesticides, yet the research community lacks adequate techniques to measure the size and concentration of ..
  10. Lung Toxicity of Carbon Nanotubes in Models of Pre-Existing Respiratory Disease
    JAMES CHRISTOPHER BONNER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Rapid advances in nanotechnology will be accompanied by the exposure of millions of individuals to products containing nanomaterials...
  11. Theranostic Nanomedicine for Breast Cancer Prevention and Image-Guided Therapy
    Prakash R Rai; Fiscal Year: 2013
    Abstract This proposal uses a nanotechnology and optical imaging-based strategy for prevention (AIM 1) and image- guided treatment (Aim 2) of breast cancer (BrCa) by targeting several key molecular targets in 3D cultures and orthotopic ..
  12. Nanodiagnostics and Nanotherapeutics: Building Research Ethics and Oversight
    Susan M Wolf; Fiscal Year: 2010
    ..A focal area of development is nanodiagnostics and nanotherapeutics. These fields use nanotechnology to develop nanoscale tools for in vitro diagnostics, in vivo imaging agents, drugs and therapies, targeted ..
  13. Transport ATPases: From Molecules to Maladies
    Rajini Rao; Fiscal Year: 2010
    ..for a deep, mechanistic understanding of human pathologies, paving the way for new therapies and advances in nanotechnology. An impetus for the conference is the rapidly growing number of diseases associated with Transport ATPases, ..
  14. Molecular mechanism of antiangiogenic properties of gold nanoparticle
    Priyabrata Mukherjee; Fiscal Year: 2013
    b>Nanotechnology is a burgeoning field and brings with it a myriad of opportunities and possibilities for advancing medical science and disease treatment...
  15. INTRACOCHLEAR ELECTROCHEMICAL GRADIENTS
    Alexander A Spector; Fiscal Year: 2012
    ..physical principles underlying the outer hair cell motor will contribute to the emerging field of biological nanotechnology. These studies may lead to improved therapeutic interventions for the hearing impaired...
  16. Mechanisms of Virus Replication and Gene Expression
    ANNE ELIZABETH SIMON; Fiscal Year: 2013
    ..range of expertise, from cellular and molecular biology to genomics and evolution, and from biochemistry to nanotechnology and vaccine development Trainees progress through innovative rotations, advanced courses in molecular and ..
  17. Influenza therapy by Au-nanorod 5'PPP-NS1-siRNA/cDNA targeting of bronchial cells
    Paul R Knight; Fiscal Year: 2010
    ..prophylactic and therapeutic non-viral gene transfer strategies that target pulmonary cells in vivo employing nanotechnology. The lung is especially well suited for these treatment strategies as direct contact with the environment ..
  18. Low Cost Diagnosis of Disease using Synthetic DNA Reactions
    William L Hughes; Fiscal Year: 2013
    ..discovery, and characterization of zinc oxide nanostructures for piezoelectric applications towards DNA-based nanotechnology for medical benefit...
  19. Role of CD98 Glycoprotein in Intestinal Inflammation
    Hamed Laroui; Fiscal Year: 2013
    ..The efficacy of knockdown of CD98 expression in inflamed colon will subsequently be assessed using a targeted nanotechnology approach...
  20. Multifunctional nanoparticles to improve treatment of human glioblastoma
    Miqin Zhang; Fiscal Year: 2013
    ..This strategy combines the advances in forefront research of GBM cancer biology with advanced nanotechnology in tumor imaging and therapeutics to circumvent the resistance to treatment...
  21. Designing an Integrated Nanoscale System for Ion Channel Structure-Function Study
    Ratneshwar Lal; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Overall goal of this application is to design and develop nanotechnology to study key nanoscale biostructures - Ion channels and receptors that are essential for all living functions...
  22. Microvascular Health and Nanoparticle Exposure
    Timothy R Nurkiewicz; Fiscal Year: 2010
    ..morbidity and mortality) from exposure to larger particles and the considerably dynamic nature of nanotechnology, identifying the health effects of nanoparticle exposure may prove far more challenging...
  23. Personalized therapeutics for inhibiting breast cancer metastasis
    DEBRA AUGUSTE; Fiscal Year: 2012
    ..I propose to use our knowledge and experience in chemical engineering, material science, and nanotechnology to develop therapeutics that will increase breast cancer patient survival by inhibiting tumor progression and ..
  24. Nanotechnology for Multiplexed and Intraoperative Cancer Detection
    Shuming Nie; Fiscal Year: 2010
    ..DESCRIPTION (Provided by the applicant): This GO grant application aims to integrate the unique capabilities of nanotechnology and innovative optical instrumentation for broad applications in cancer surgery...
  25. Long-Term Non-Enzymatic Glucose Sensors for an Artificial Pancreas
    NATALIE ANN WISNIEWSKI; Fiscal Year: 2013
    ..Multiple nanotechnology-based stabilizing agents will be employed...
  26. Understanding and Eliminating Oncogenic EGFR Signaling in Malignant Glioma
    Alain Charest; Fiscal Year: 2013
    ..5) To ascertain toxicity profiles and efficacy spectrum of various nanotechnology platforms for the efficient delivery of small interfering RNA (siRNA) molecules to GBM tumor cells in vivo...
  27. Nanoparticle Analysis of Enveloped Virus Entry Pathways
    Robert Davey; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): In the field of nanotechnology, much attention has been paid to the construction of nanometer- sized particles that can harbor drugs and other therapeutic agents...
  28. siRNA-gold nanoparticle mediated ganglioside depletion for diabetic wound healing
    AMY SUSAN PALLER; Fiscal Year: 2013
    ..We propose that genetic inhibition of ganglioside synthesis through the use of a novel nanotechnology approach will reverse impaired wound healing in KCs under high glucose conditions and in diabetic mice...
  29. QD-BRET nanosensors for protease detection and imaging
    Jianghong Rao; Fiscal Year: 2012
    ..This research proposes to develop a novel nanotechnology-based sensing and imaging system for sensitive, accurate, and multiplex detection and imaging of MMPs in ..
  30. Genetic Susceptibility to Nanoparticle-Induced Respiratory Disease
    JAMES CHRISTOPHER BONNER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Rapid advances in nanotechnology will be accompanied by the exposure of millions of individuals to products containing nanomaterials...
  31. Nano-Antioxidants as a Therapeutic for Preclinical Models of NAFLD
    Robia G Pautler; Fiscal Year: 2013
    ..activity, that do not pass radicals on to other molecules and that can be targeted, we have turned to nanotechnology. These nano-antioxidants, polyethylene glycolated hydrophilic carbon clusters (PEG-HCCs), are based on carbon ..
  32. TRAINING IN BIOMOLECULAR PHARMACOLOGY
    David H Farb; Fiscal Year: 2013
    ..genomics, gene therapy, proteomics, animal models (transgenic and behavioral), structural biology, nanotechnology, systems biology and medicinal chemistry...
  33. Tri-modal Polymeric Micelles for 'See &Treat'Applications in Surgical Oncology
    Glen S Kwon; Fiscal Year: 2012
    ..The goal is to develop nanotechnology for "see and treat" modalities in surgical oncology, enabled by polymeric micelles that emit tissue ..
  34. Rapid Novel Molecular Detection of Methicillin-Resistant Staphylococcus aureus
    ELENA ANATOLIEVNA USACHEVA; Fiscal Year: 2010
    ..to integrate our algorithm with their nanotechnology and detection platform and evaluate the feasibility for developing a reliable, cost-effective diagnostic ..
  35. Defining Target Contribution to Orofacial Pain by Antisense Oligonucleotides
    Zhigang Luo; Fiscal Year: 2009
    ..One is to use novel nanotechnology in delivering agents with therapeutic potential to block injury-induced orofacial pain and target gene ..
  36. Molecularly guided multimodal theranostics for breast cancer
    Amit Joshi; Fiscal Year: 2013
    ..Hence, the early thrust of cancer nanotechnology was focused towards the development of nanocarriers for delivering diagnostic/therapeutic payloads to improve ..
  37. Boosting anti-tumor immune responses by modulating genes with nanoparticles
    Jose R Conejo-Garcia; Fiscal Year: 2010
    ..To accomplish these aims, we have assembled a multidisciplinary team combining expertise in nanotechnology and tumor immunology...
  38. Integrative Cancer Nanoscience and Microsystems (IC-NSMS) Training Center
    Janet M Oliver; Fiscal Year: 2013
    ..IC-NSMS training via a boot camp to immerse new students in the integration of cancer biology and nanotechnology, an oncologist-led seminar on real-world problems in cancer prevention, detection and treatment and an ..
  39. Instrument for Single Molecule Sequencing of Alzheimer's-Relevant Genomic Oxidati
    David E Wolf; Fiscal Year: 2012
    ..proposes to develop a single molecule DNA sequencing nanotechnology sensitive to a wide variety of DNA modifications, including those central to the pathogenesis of Alzheimer&..
  40. Asia-ARVO Travel Awards and Symposium
    Sally S Atherton; Fiscal Year: 2010
    ..NIH including translational research, global health, high throughput technologies (genomics, proteomics, and nanotechnology), and health disparities...
  41. Nanoconjugate based on polymalic acid for brain tumor treatment
    Julia Y Ljubimova; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Recent advances in nanotechnology may offer a new hope for a significant improvement and success of cancer treatment, especially in preventing tumor growth and progression...
  42. Cigarette Smoke and Autophagy/Lysosomal Pathway Dysfunction
    Martha M Monick; Fiscal Year: 2013
    ..macrophages will be investigated using state-of-the-art facilities available in the University of Iowa, Nanotechnology Institute...
  43. MicroRNA pathway in mechanisms of nanoparticles neurotoxicity
    Alexander K Murashov; Fiscal Year: 2010
    ..These cylindrical structures have novel properties that make them useful in many applications in nanotechnology, electronics, optics, as well as in medicine...
  44. Alzheimer's Drug Discovery Using Unique Nanotechnology Platform
    William L Klein; Fiscal Year: 2013
    ..This project is expected to have strong potential to identify lead compounds that target binding of synaptotoxic Ab oligomers to their receptors, an underexploited but critical early-step in AD pathogenesis. ..
  45. Hybridization Chain Reaction: In Situ Amplification for Biological Imaging
    Niles A Pierce; Fiscal Year: 2013
    ..Here, we draw on concepts from the field of nucleic acid nanotechnology to design and validate in situ am- plifiers based on the mechanism of hybridization chain reaction (HCR)...
  46. Bio-imaging with Isothermal DNA Self-Assembly
    David Yu Zhang; Fiscal Year: 2013
    ..DNA nanotechnology can, in principle, improve bio-imaging performance in all four categories, but conventional DNA nanotechnology ..
  47. Bio-imaging with Isothermal DNA Self-Assembly
    David Yu Zhang; Fiscal Year: 2013
    ..DNA nanotechnology can, in principle, improve bio-imaging performance in all four categories, but conventional DNA nanotechnology ..
  48. Targeted Gene Therapy and Nanomedicine Approaches to Treat Corneal Diseases
    RAJIV RAVINDRA MOHAN; Fiscal Year: 2012
    ..for transporting therapeutic genes into keratocytes of the rabbit cornea in vivo, can provide safe and novel nanotechnology-based nonviral gene therapy modalities to treat corneal diseases, and targeted delivery genes disabling ..
  49. Determination of Markers of High Pathogenicity in Influenza
    Richard A Dluhy; Fiscal Year: 2013
    ..This project will ultimately demonstrate that bio-nanotechnology combined with vibrational spectroscopy has the ability to enhance detection and diagnosis of emerging viral ..
  50. Novel Influenza A Nanovaccines for Broad Cross Protection
    Baozhong Wang; Fiscal Year: 2013
    ..We will use the newest nanotechnology approach to produce nanoclusters self-assembled directly from the resulting antigenic proteins as universal ..
  51. Interdisciplinary Biomedical Research Training Program
    Samuel L Jones; Fiscal Year: 2013
    ..Engineering and Textiles, Statistics and Epidemiology, Biological Chemistry, and Pharmacology, Toxicology, and Nanotechnology. Research projects will emphasize the melding of two disciplines to create a novel approach to a biomedical ..
  52. Enzyme-Responsive Nanoemulsions as Tumor-Specific Ultrasound Contrast Agents for
    Andrew P Goodwin; Fiscal Year: 2011
    ..Andrew Goodwin for a Pathway to Independence Award in Cancer Nanotechnology (RFA-CA-09-015)...
  53. Novel nanotechnology based oral influenza vaccines
    Sang Moo Kang; Fiscal Year: 2011
    ..In our quest to advance to the next generation of vaccines using novel nanotechnology formulation, we propose to encapsulate influenza vaccines into stabilized small beadlike particles containing ..
  54. Computational Studies of Early Stage Cell Entry Events by Non-enveloped Viruses
    ERIC ROBERT MAY; Fiscal Year: 2013
    ..My interest in understanding elastic properties of viral capsids is both to enhance nanotechnology design efforts but also to understand morphological changes in capsids related to virus life cycle events...
  55. Training Grant in Academic Nephrology
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2013
    ..fluid exchange, physiology and pharmacology of vasoactive hormones, human and mouse genetics, bioengineering, nanotechnology, tissue engineering, regenerative biology, and immunological mechanisms in kidney diseases...
  56. University of New Mexico Cancer Center Support
    Cheryl L Willman; Fiscal Year: 2013
    ..mortality, and disparity;the integration of regional scientific strengths in engineering, biotechnology, nanotechnology, radioisotopes, drug discovery, imaging, and high performance computing into its Research Programs and Shared ..
  57. Nanotechnology for Minimally Invasive Cancer Detection and Resection
    Aaron M Mohs; Fiscal Year: 2011
    ..The primary goal of this Pathway to Independence Award in Cancer Nanotechnology Research (K99/R00) proposal is to integrate the unique capabilities of nanotechnology with innovative optical ..
  58. Nanotechnology enabled desktop image-guided microbeam radiation therapy system
    OTTO Z contact ZHOU; Fiscal Year: 2010
    ..image guided radiation therapy system developed jointly with Siemens Oncology using the same enabling nanotechnology. The image guidance system is capable of 3D imaging in real time and during radiation delivery, a highly ..
  59. Enhancing Intestinal &Brain Uptake of Anti-AIDS Drugs
    Patrick J Sinko; Fiscal Year: 2013
    ..Utilizing a nanotechnology approach, the proposed research will develop novel anti-HIV therapeutics that will dramatically increase ..
  60. A rapid label-free sensor for immune markers of environmental exposure for applic
    Christopher Striemer; Fiscal Year: 2012
    ..The explosive growth of nanotechnology in research and consumer products (sunscreens, cosmetics, paint) is also creating an array of ultrafine ..
  61. Use of Silver Nanostructures on Microtransponders in Ultra-sensitive Assay
    Wlodek Mandecki; Fiscal Year: 2011
    ..The assay has a potential to also improve PCa disease management. Acceptance of nanotechnology-based multiplex assays on microtransponders by researchers and clinicians could initiate new methods in ..
  62. Nanotechnology-based Theranostic Technology for Bone Tissue Engineering
    Balaji Sitharaman; Fiscal Year: 2010
    ..in this application for the NIH Director's New Innovator Award is to engineer the next generation of nanotechnology-based theranostic (diagnostic + therapeutic) technology that will facilitate non-invasive imaging, and at the ..
  63. Nanotechnology Enabled Temporomandibular Joint (TMJ) Prosthesis
    RAYMOND G THOMPSON; Fiscal Year: 2010
    ..Our specific aims are as follows: Specific Aim 1: Develop nanotechnology for reducing friction and wear on the articulating, load-bearing components of TMJ metallic implants (condyle ..
  64. Optimization of SWCNT/siRNA complex formulation for tumor accumulation
    Lynn Kirkpatrick; Fiscal Year: 2012
    ..is a biotechnology company located in Houston, TX, exploiting the pionering nanotechnology studies of the late 1996 Nobel Laureate, Dr. Richard Smalley of Rice University. The rights to Dr...
  65. RNA Nanomotor Based Active Devices for Biology and Medicine
    Rashid Bashir; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Nanotechnology is truly revolutionizing our ability to manufacture and design active devices and systems that are small, cheap, and ultra-sensitive...
  66. Catalytic DNA Biosensor for Toxic Metal Ions
    Yi Lu; Fiscal Year: 2009
    ..of state-of-the-art tools in catalytic DNA biology, catalytic molecular beacons biotechnology and nanoparticle nanotechnology. Catalytic DNA molecules specific for heavy metal ions will be obtained through in vitro selection, and ..
  67. Dual Antigen Nanoparticle Vaccine System For Bacillus Infectious Disease
    Puthupparampil Scaria; Fiscal Year: 2009
    Development of rationally designed vaccines is an important need that nanotechnology has tremendous potential to transform. Already nanoparticle developments are incorporated into approved small molecule therapeutics...
  68. DNA-modulated release of drug from melanoma targeting NP
    Kit Lam; Fiscal Year: 2009
    ..b>Nanotechnology is an emerging field that has shown promise for the development of novel diagnostic, imaging and therapeutic ..
  69. Shape Specific, Enzyme-Responsive, Nano-Imprinted Particles for Drug Delivery
    Krishnendu Roy; Fiscal Year: 2009
    b>Nanotechnology is one of the most promising avenues for the development of advanced drug delivery vehicles. Classically, the field has focused on synthesizing nanocarriers based on self assembly or emulsion based concepts...
  70. A Nanotechnology Enabled Point of Care Diagnostic Platform for Early Stage Cancer
    James Nelson; Fiscal Year: 2009
    ..We propose to develop a nanotechnology enabled protein signature based diagnostic test for prostate cancer available at the point of primary care.
  71. Nanotechnology for One Step Concentration and Preservation of Labile Biomarkers i
    LANCE ALLEN LIOTTA; Fiscal Year: 2010
    ..This project will deliver a novel nanotechnology that can rapidly harvest, concentrate, and protect from degradation, labile biomarkers in whole blood or serum,..
  72. Enhancing Faculty Recruitment in Nanoscale Sciences for Biomedical Research
    Yogesh K Vohra; Fiscal Year: 2010
    ..and health professions, the Center is uniquely positioned to be at the forefront of biomaterials research and nanotechnology development for improving human health...
  73. Novel Cancer Nanotechnology Platforms for Photodynamic Therapy and Imaging
    Ravindra Pandey; Fiscal Year: 2009
    ..Paras Prasad, PhD (UB), will lead development and photophysical characterization of the Ormosil platform. Raoul Kopelman, PhD (UM), will lead development and photophysical characterization the polyacrylamide platform. ..