surface tension

Summary

Top Publications

  1. ncbi Surface tension transport of prey by feeding shorebirds: the capillary ratchet
    Manu Prakash
    Center for Bits and Atoms, Massachusetts Institute of Technology MIT, 20 Ames Street, Cambridge, MA 02139, USA
    Science 320:931-4. 2008
  2. ncbi Interfacial tension of phosphatidylcholine-cholesterol system in monolayers at the air/water interface
    Izabela Brzozowska
    Laboratory of Interfacial Electrochemistry, Faculty of Chemistry, University of Warsaw, PL 02 093, Pasteura 1, Warsaw, Poland
    Biophys Chem 95:173-9. 2002
  3. ncbi Physicochemical parameters associated with nanoparticle formation in the salting-out, emulsification-diffusion, and nanoprecipitation methods
    Sergio Galindo-Rodriguez
    Pharmapeptides, Geneva Lyon Interuniversity Centre, 74166 Archamps, France
    Pharm Res 21:1428-39. 2004
  4. pmc Deformation and flow of membrane into tethers extracted from neuronal growth cones
    F M Hochmuth
    Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina 27708, USA
    Biophys J 70:358-69. 1996
  5. ncbi Comparison of methods to detect biosurfactant production by diverse microorganisms
    Noha H Youssef
    Department of Botany and Microbiology, University of Oklahoma, 770 Van Vleet Oval Norman, OK 73019, USA
    J Microbiol Methods 56:339-47. 2004
  6. pmc Pulmonary surfactant surface tension influences alveolar capillary shape and oxygenation
    Machiko Ikegami
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Respir Cell Mol Biol 41:433-9. 2009
  7. pmc Coaction of intercellular adhesion and cortical tension specifies tissue surface tension
    M Lisa Manning
    Princeton Center for Theoretical Science, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 107:12517-22. 2010
  8. ncbi Interfacial tension of bilayer lipid membrane formed from phosphatidylethanolamine
    Aneta D Petelska
    Institute of Chemistry, University of Bialystok, Al J Pilsudskiego 11 4, Bialystok 15 443, Poland
    Biochim Biophys Acta 1567:79-86. 2002
  9. ncbi Well-defined critical association concentration and rapid adsorption at the air/water interface of a short amphiphilic polymer, amphipol A8-35: a study by Förster resonance energy transfer and dynamic surface tension measurements
    Fabrice Giusti
    UMR 7099, CNRS Université Paris 7, Institut de Biologie Physico Chimique, 13 rue Pierre et Marie Curie, F 75005 Paris, France
    Langmuir 28:10372-80. 2012
  10. ncbi The Differential Interfacial Tension Hypothesis (DITH): a comprehensive theory for the self-rearrangement of embryonic cells and tissues
    G Wayne Brodland
    Department of Civil Engineering, University of Waterloo, ON, Canada
    J Biomech Eng 124:188-97. 2002

Research Grants

  1. MECHANISMS IN THE REGULATION OF SP-A GENE EXPRESSION
    Carole R Mendelson; Fiscal Year: 2013
  2. Lipid Droplet Metabolism
    Fredric B Kraemer; Fiscal Year: 2013
  3. Anionic Surfactant Lipid Regulation of Inflammation and Infection in the Lung
    Dennis R Voelker; Fiscal Year: 2013
  4. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard B Weinberg; Fiscal Year: 2010
  5. Hormonal Regulation of Surfactant Protein mRNA Stability
    Joseph L Alcorn; Fiscal Year: 2012
  6. Pulmonary Surfactant and Lung Homeostasis
    John R Perfect; Fiscal Year: 2012
  7. LIPID AND PROTEIN EFFECTS ON MONOLAYER STABILITY
    JOSEPH ANTHONY ZASADZINSKI; Fiscal Year: 2013
  8. Antibacterial Perfluorocarbon Ventilation to Treat Severe Respiratory Infections
    KEITH ELLIOT COOK; Fiscal Year: 2013
  9. Stability of Pullmonary Airways
    JAMES BERNARD GROTBERG; Fiscal Year: 2010
  10. Improving Inhaled Drug Delivery with Self-dispersing Liquids
    STEPHEN GAROFF; Fiscal Year: 2013

Detail Information

Publications308 found, 100 shown here

  1. ncbi Surface tension transport of prey by feeding shorebirds: the capillary ratchet
    Manu Prakash
    Center for Bits and Atoms, Massachusetts Institute of Technology MIT, 20 Ames Street, Cambridge, MA 02139, USA
    Science 320:931-4. 2008
    ..One such feeding mechanism in shorebirds involves surface tension-induced transport of prey in millimetric droplets: By repeatedly opening and closing its beak in a tweezering ..
  2. ncbi Interfacial tension of phosphatidylcholine-cholesterol system in monolayers at the air/water interface
    Izabela Brzozowska
    Laboratory of Interfacial Electrochemistry, Faculty of Chemistry, University of Warsaw, PL 02 093, Pasteura 1, Warsaw, Poland
    Biophys Chem 95:173-9. 2002
    ..Its value equals 18 mN/m. The difference between the stability constant of 1:1 complex in the bilayer and the monolayer at the air/water interface is discussed...
  3. ncbi Physicochemical parameters associated with nanoparticle formation in the salting-out, emulsification-diffusion, and nanoprecipitation methods
    Sergio Galindo-Rodriguez
    Pharmapeptides, Geneva Lyon Interuniversity Centre, 74166 Archamps, France
    Pharm Res 21:1428-39. 2004
    ..The aim of this work was to relate the physicochemical properties of the aqueous and organic phases used for nanoparticle (NP) preparation to the formation of NP produced by salting-out, emulsification-diffusion, and nanoprecipitation...
  4. pmc Deformation and flow of membrane into tethers extracted from neuronal growth cones
    F M Hochmuth
    Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina 27708, USA
    Biophys J 70:358-69. 1996
    ..7 x 10(-19) N.m and an extraordinarily small "apparent surface tension" in the growth cone of 0...
  5. ncbi Comparison of methods to detect biosurfactant production by diverse microorganisms
    Noha H Youssef
    Department of Botany and Microbiology, University of Oklahoma, 770 Van Vleet Oval Norman, OK 73019, USA
    J Microbiol Methods 56:339-47. 2004
    ..were compared for their ease of use and reliability in relation to the ability of the cultures to reduce surface tension. The three methods were used to test for biosurfactant production in 205 environmental strains with different ..
  6. pmc Pulmonary surfactant surface tension influences alveolar capillary shape and oxygenation
    Machiko Ikegami
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Respir Cell Mol Biol 41:433-9. 2009
    ..hypothesized that the shape of alveolar capillaries and accompanying oxygenation are influenced by surfactant surface tension in the alveolus...
  7. pmc Coaction of intercellular adhesion and cortical tension specifies tissue surface tension
    M Lisa Manning
    Princeton Center for Theoretical Science, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 107:12517-22. 2010
    ..Based on this similarity, it has been proposed that tissues behave as liquids and possess a characteristic surface tension, which arises as a collective, macroscopic property of groups of mobile, cohering cells...
  8. ncbi Interfacial tension of bilayer lipid membrane formed from phosphatidylethanolamine
    Aneta D Petelska
    Institute of Chemistry, University of Bialystok, Al J Pilsudskiego 11 4, Bialystok 15 443, Poland
    Biochim Biophys Acta 1567:79-86. 2002
    ..A theoretical equation is derived to describe this dependence in the whole pH range. A maximum corresponding to the isoelectric point appears both in the theoretical equation and in the experimental data...
  9. ncbi Well-defined critical association concentration and rapid adsorption at the air/water interface of a short amphiphilic polymer, amphipol A8-35: a study by Förster resonance energy transfer and dynamic surface tension measurements
    Fabrice Giusti
    UMR 7099, CNRS Université Paris 7, Institut de Biologie Physico Chimique, 13 rue Pierre et Marie Curie, F 75005 Paris, France
    Langmuir 28:10372-80. 2012
    ..This indicates that assembly takes place in a narrow concentration interval around 0.002 g·L(-1). Surface tension measurements decreases regularly with concentration until a threshold of ca. 0...
  10. ncbi The Differential Interfacial Tension Hypothesis (DITH): a comprehensive theory for the self-rearrangement of embryonic cells and tissues
    G Wayne Brodland
    Department of Civil Engineering, University of Waterloo, ON, Canada
    J Biomech Eng 124:188-97. 2002
    ..The theory is used to derive conditions for the cell and tissue rearrangements named above. Finite element-based computer simulations involving two or more cell types confirm these conditions...
  11. pmc Development of a low-resource RNA extraction cassette based on surface tension valves
    Hali Bordelon
    Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235, USA
    ACS Appl Mater Interfaces 3:2161-8. 2011
    ..Processing solutions are separated by air gaps and held in place during processing by the surface tension forces at the liquid-air interface, viz. surface tension valves...
  12. ncbi Role for stress fiber contraction in surface tension development and stretch-activated channel regulation in C2C12 myoblasts
    Francesca Sbrana
    Department of Physics, Centro Studi Dinamiche Complesse, University of Florence, Florence, Italy
    Am J Physiol Cell Physiol 295:C160-72. 2008
    ..Together, these data provide the first experimental evidence for a crucial role of SF contraction in SAC activation. The related changes in cell viscosity may prevent SAC from abnormal activation...
  13. ncbi Biophysics: water-repellent legs of water striders
    Xuefeng Gao
    Key Laboratory of Organic Solids, Institute of Chemistry, Beijing 100080, China
    Nature 432:36. 2004
    ..We show here, however, that it is the special hierarchical structure of the legs, which are covered by large numbers of oriented tiny hairs (microsetae) with fine nanogrooves, that is more important in inducing this water resistance...
  14. pmc Inhibition of pulmonary surfactant adsorption by serum and the mechanisms of reversal by hydrophilic polymers: theory
    Joseph A Zasadzinski
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    Biophys J 89:1621-9. 2005
    ..Natural hydrophilic polymers, like the SP-A present in native surfactant, or hyaluronan, normally present in the alveolar fluids, can enhance adsorption in the presence of serum to eliminate inactivation...
  15. ncbi Flow rate analysis of a surface tension driven passive micropump
    Erwin Berthier
    MacDiarmid Institute for Advanced Materials and Nanotechnology, Department of Electrical and Computer Engineering, University of Canterbury, Christchurch, NZ
    Lab Chip 7:1475-8. 2007
    A microfluidic passive pumping method relying on surface tension properties is investigated and a physical model is developed...
  16. ncbi New protocols for preparing dipalmitoylphosphatidylcholine dispersions and controlling surface tension and competitive adsorption with albumin at the air/aqueous interface
    Sook Heun Kim
    School of Chemical Engineering, Purdue University, 480 Stadium Mall Drive, West Lafayette, IN 47907 2100, USA
    Colloids Surf B Biointerfaces 43:256-66. 2005
    ..with Trurnit's method or when dispersion drops are sprayed onto the surface of a DPPC/BSA mixture, the surface tension becomes lower and is controlled by DPPC, which can prevent the adsorption of BSA...
  17. ncbi Design of peptidyl compounds that affect beta-amyloid aggregation: importance of surface tension and context
    Todd J Gibson
    Department of Chemical and Biological Engineering, University of Wisconsin, 1415 Engineering Drive, Madison, Wisconsin 53706, USA
    Biochemistry 44:8898-907. 2005
    ..In all cases, the hybrid compound's ability to increase solvent surface tension was the strongest predictor of its effect on Abeta aggregation kinetics...
  18. ncbi Alpha5beta1 integrin mediates strong tissue cohesion
    Elizabeth E Robinson
    Department of Surgery, University of Medicine and Dentistry Robert Wood Johnson Medical School, CAB Room 7070, New Brunswick, NJ 08648, USA
    J Cell Sci 116:377-86. 2003
    ..Collectively, these data confirm our hypothesis that alpha5beta1 integrin acts through fibronectin to link adjacent cells together, thus promoting strong intercellular cohesion in 3D cellular aggregates...
  19. ncbi Control of surface tension at liquid-liquid interfaces using nanoparticles and nanoparticle-protein complexes
    Subinoy Rana
    Department of Chemistry, University of Massachusetts at Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA
    Langmuir 28:2023-7. 2012
    ..Using dynamic surface tension measurements, we observed a linear decrease in the meso-equilibrium surface tension (γ) and faster dynamics ..
  20. ncbi Saponins can perturb biologic membranes and reduce the surface tension of aqueous solutions: a correlation?
    Stefan Böttger
    Institut fur Pharmazie, Pharmazeutische Biologie, Freie Universitat Berlin, Konigin Luise Str 2 4, 14195 Berlin, Germany
    Bioorg Med Chem 20:2822-8. 2012
    ..The surfactant behavior lets them lower the surface tension in aqueous solutions and form micelles when reaching the critical micelle concentration (cmc)...
  21. ncbi Colloid transport with wetting fronts: interactive effects of solution surface tension and ionic strength
    Jie Zhuang
    Institute for a Secure and Sustainable Environment, Department of Biosystems Engineering and Soil Science, The University of Tennessee, Knoxville, TN 37996 4134, USA
    Water Res 44:1270-8. 2010
    ..The saturated transport experiments demonstrated that decreasing solution surface tension and ionic strength decreased colloid deposition at the solid-liquid interface and increased colloid recovery ..
  22. ncbi Surface tension-mediated, concave-microwell arrays for large-scale, simultaneous production of homogeneously sized embryoid bodies
    Gi Seok Jeong
    Department of Biomedical Engineering, College of Health Science, Korea University, Seoul, Korea
    Adv Healthc Mater 2:119-25. 2013
    ..The large number of concave well structures is self-constructed through the surface tension of the viscoelastic PDMS prepolymer...
  23. ncbi Surface tension propulsion of fungal spores
    Xavier Noblin
    Laboratoire de Physique de la Matiere Condensee, CNRS UMR 6622, Universite de Nice Sophia Antipolis, Parc Valrose, 06108 Nice, Cedex 2, France
    J Exp Biol 212:2835-43. 2009
    ..The fusion of the droplet onto the spore creates a momentum that propels the spore forward. The use of surface tension for spore ejection offers a new paradigm to perform work at small length scales...
  24. ncbi Solubilization behavior of poorly soluble drugs with combined use of Gelucire 44/14 and cosolvent
    Kohsaku Kawakami
    Developmental Research Laboratories, Shionogi and Co, Ltd, 12 4 Sagisu 5 chome, Fukushima ku, Osaka 553 0002, Japan
    J Pharm Sci 93:1471-9. 2004
    ..Gelucire was confirmed to form micelles by surface tension and fluorescence measurements both in water and water/cosolvent mixtures...
  25. ncbi Surface tension influences cell shape and phagocytosis in alveolar macrophages
    Hiroko Akei
    Cincinnati Children s Hospital, Division of Pulmonary Biology, University of Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 291:L572-9. 2006
    The effect of surface tension on alveolar macrophage shape and phagocytosis was assessed in vivo and in vitro. Surface tension was regulated in vivo by conditionally expressing surfactant protein (SP)-B in Sftpb-/- mice...
  26. ncbi The role of the gel <=> liquid-crystalline phase transition in the lung surfactant cycle
    M Gugliotti
    , , , , Brazil
    Biophys Chem 89:243-51. 2001
    ..Based on these results, an explanation on how fluid aggregates in the alveolar subphase can form a rigid monolayer at the alveolar interface is proposed...
  27. ncbi Molecular dynamics simulations of the surface tension and structure of salt solutions and clusters
    Lu Sun
    Department of Theoretical Chemistry and Biology, School of Biotechnology, Royal Institute of Technology, S 10691 Stockholm, Sweden
    J Phys Chem B 116:3198-204. 2012
    ..Interfacial properties, including surface tension and halide anion distributions, are crucial issues in the study of the aerosols...
  28. ncbi Surface tension comparison of four common root canal irrigants and two new irrigants containing antibiotic
    Luciano Giardino
    Department of Periodontology, Dental, School, University of Brescia, Italy
    J Endod 32:1091-3. 2006
    The aim of this study is to compare the surface tension of four common endodontic irrigants: Moltendo EDTA 17%, Cetrexidin, Smear Clear, Sodium hypochlorite 5.25%, with the surface tension of MTAD and Tetraclean...
  29. ncbi The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice
    Angela Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical School, Philadelphia 19104, USA
    Am J Physiol Lung Cell Mol Physiol 283:L755-65. 2002
    ..reductions in surfactant protein (SP)-B, a hydrophobic surfactant protein responsible for maintaining low surface tension of the lining fluid of distal air spaces...
  30. pmc Fine tuning of tissues' viscosity and surface tension through contractility suggests a new role for α-catenin
    Tomita Vasilica Stirbat
    Institut Lumière Matière, UMR5306 Université Lyon 1 CNRS, Universite de Lyon, Villeurbanne, Lyon, France
    PLoS ONE 8:e52554. 2013
    ..time ago an analogy between liquids and tissues and showed that indeed tissues possess a measurable tissue surface tension and viscosity...
  31. ncbi Component-specific surface and physiological activity in bovine-derived lung surfactants
    Robert H Notter
    Department of Pediatrics Neonatology, Box 777, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Chem Phys Lipids 114:21-34. 2002
    ..Survanta had lower adsorption, higher minimum surface tension, and a smaller effect on surfactant-deficient P-V mechanics consistent with minimal contributions from SP-B...
  32. pmc Lung surfactant protein SP-B promotes formation of bilayer reservoirs from monolayer and lipid transfer between the interface and subphase
    Svetlana Baoukina
    Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada
    Biophys J 100:1678-87. 2011
    ..On interface expansion, the flow of lipids to the monolayer restored the surface tension to the equilibrium spreading value...
  33. ncbi Folding of lipid monolayers containing lung surfactant proteins SP-B(1-25) and SP-C studied via coarse-grained molecular dynamics simulations
    Susan L Duncan
    Dept of Chemical Engineering, University of Michigan, 2300 Hayward St, 3074 H H Dow Building, Ann Arbor, Michigan 48109, USA
    Biochim Biophys Acta 1798:1632-50. 2010
    ..In addition to promoting fold formation, the peptides also display fusogenic behavior, which can lead to surface refining...
  34. ncbi Fusion of vesicles with the air-water interface: the influence of polar head group, salt concentration, and vesicle size
    M Gugliotti
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Av Prof Lineu Prestes 748, 05508 940, Sao Paulo, Brazil
    Biochim Biophys Acta 1463:301-6. 2000
    ..For the zwitterionic vesicles, plots of the initial surface pressure increase rate (surface tension decrease rate) as a function of temperature show a peak at the phase transition temperature (T(m)) of the ..
  35. ncbi Characterisation of the interaction of lactate dehydrogenase with Tween-20 using isothermal titration calorimetry, interfacial rheometry and surface tension measurements
    William J McAuley
    The School of Pharmacy, The Queen s University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Pharm Sci 98:2659-69. 2009
    ..of the protein and surfactant on the interfacial properties were followed with interfacial rheology and surface tension measurements in order to understand the mechanism by which the surfactant prevents protein adsorption to the ..
  36. ncbi Aggregation behavior of sodium dioctylsulfosuccinate in aqueous ethylene glycol medium. A case of hydrogen bonding between surfactant and solvent and its manifestation in the surface tension isotherm
    D Das
    Department of Chemistry, North Eastern Hill University, Shillong, India
    Langmuir 28:15762-9. 2012
    ..present study cmc of AOT in water + EG medium in the range from 0 to 100% (by weight) EG is measured by using surface tension and fluorescence emission methods...
  37. ncbi Relating cell and tissue mechanics: implications and applications
    Karoly Jakab
    Department of Physics and Astronomy, University of Missouri, Columbia, Missouri 65211, USA
    Dev Dyn 237:2438-49. 2008
    ..A manifestation of differential adhesion is tissue liquidity and a measure for it is tissue surface tension. In terms of this property, DAH correctly predicts global developmental tissue patterns...
  38. ncbi Surface tension phenomena in the xylem sap of three diffuse porous temperate tree species
    Karen K Christensen-Dalsgaard
    Department of Renewable Resources, 4 44 ESB, University of Alberta, Edmonton, Alberta T6G2E3, Canada
    Tree Physiol 31:361-8. 2011
    ..physiology models involving bubble nucleation, expansion or elimination, it is typically assumed that the surface tension of xylem sap is equal to that of pure water, though this has never been tested...
  39. ncbi The interfacial tension of the lipid membrane formed from lipid-cholesterol and lipid-lipid systems
    Aneta D Petelska
    Institute of Chemistry, University of Bialystok, Al J Pilsudskiego 11 4, 15 443 Bialystok, Poland
    Cell Biochem Biophys 44:205-11. 2006
    ....
  40. ncbi Acid-base equilibria at interface separating electrolyte solution and lipid bilayer formed from phosphatidylcholine
    Aneta D Petelska
    Laboratory of Interfacial Electrochemistry, Faculty of Chemistry, University of Warsaw, Pasteur St 1, 02 093 Warsaw, Poland
    Biophys Chem 104:13-9. 2003
    ..We take suitable equations to describe the dependence of interfacial tension of a lipid bilayer membrane on H(+) and OH(-) ion concentrations. A theoretical equation is derived to describe this dependence in the whole pH range...
  41. ncbi Interfacial tension of the lipid membrane formed from lipid-fatty acid and lipid-amine systems
    Aneta D Petelska
    Institute of Chemistry, University of Bialystok, Al J Pilsudskiego 11 4, 15 443 Bialystok, Poland
    Bioelectrochemistry 70:28-32. 2007
    ....
  42. ncbi Non-cooperative effects of lung surfactant proteins on early adsorption to an air/water interface
    Vincent Schram
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Biochim Biophys Acta 1616:165-73. 2003
    ..kinetics to an air/water interface were monitored at different temperatures using a Wilhelmy plate to measure surface tension. When plotted versus protein concentration, the adsorption rates during the initial change in surface tension ..
  43. pmc Inactivation of pulmonary surfactant due to serum-inhibited adsorption and reversal by hydrophilic polymers: experimental
    H William Taeusch
    Pediatrics, University of California, San Francisco, California 94110, USA
    Biophys J 89:1769-79. 2005
    ....
  44. ncbi Test of the Epstein-Plesset model for gas microparticle dissolution in aqueous media: effect of surface tension and gas undersaturation in solution
    P Brent Duncan
    Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina 27708 0300, USA
    Langmuir 20:2567-78. 2004
    ..by two main factors: the concentration (undersaturation) of dissolved gas in the aqueous solution and the surface tension of the gas bubble-water interface via a Laplace overpressure in the bubble that this creates...
  45. pmc In situ biosurfactant production by Bacillus strains injected into a limestone petroleum reservoir
    N Youssef
    Department of Botany and Microbiology, University of Oklahoma, Norman, OK 73019, USA
    Appl Environ Microbiol 73:1239-47. 2007
    ..02 +/- 0.001 h(-1)), and biosurfactant yields (0.015 +/- 0.001 mol biosurfactant/mol glucose). The data demonstrate the technical feasibility of microbial processes for oil recovery...
  46. ncbi The differential adhesion hypothesis: a direct evaluation
    Ramsey A Foty
    Department of Surgery, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Dev Biol 278:255-63. 2005
    ..of liquid-like cell aggregate surface tensions have shown that, without exception, a cell aggregate of lower surface tension tends to envelop one of higher surface tension to which it adheres...
  47. ncbi Intrinsic contact angle of aqueous phases at membranes and vesicles
    Halim Kusumaatmaja
    Theory and Bio Systems, Max Planck Institute of Colloids and Interfaces, 14424 Potsdam, Germany
    Phys Rev Lett 103:238103. 2009
    ..A detailed comparison between theory and experiment provides strong evidence that the intrinsic contact angle theta(in) represents a material parameter, in contrast to the effective contact angles...
  48. pmc Metastability of a supercompressed fluid monolayer
    Ethan C Smith
    Departments of Biochemistry, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Biophys J 85:3048-57. 2003
    ..These observations indicate that in several respects, the supercompression of POPC monolayers resembles the supercooling of three-dimensional liquids toward a glass transition...
  49. ncbi Effect of plasticizer on the dynamic surface tension and the free volume of Eudragit systems
    Romána Zelkó
    Institute of Pharmacy Administration, University of Pharmacy, Semmelweis University, Hogyes E Street 7 9, H 1092 Budapest, Hungary
    Int J Pharm 244:81-6. 2002
    The purpose of the present study was to determine the changes of dynamic surface tension of aqueous Eudragit dispersions quantitatively and compare these data with the free volume of the free films formed from several dispersions of ..
  50. ncbi Insertion of tear proteins into a meibomian lipids film
    F Miano
    R and D Sifi S p A via E Patti, 36 95020 Aci S Antonio CT, Italy
    Colloids Surf B Biointerfaces 44:49-55. 2005
    ..meibomian lipid composition is therefore functional to maintain tear proteins activity...
  51. ncbi Hofmeister salt effects on surface tension arise from partitioning of anions and cations between bulk water and the air-water interface
    Laurel M Pegram
    Department of Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Phys Chem B 111:5411-7. 2007
    ..surface-bulk partitioning model to interpret the effects of individual Hofmeister cations and anions on the surface tension of water...
  52. ncbi Dynamic surface tension and adsorption mechanisms of surfactants at the air-water interface
    J Eastoe
    University of Bristol, School of Chemistry, Cantock s Close, UK
    Adv Colloid Interface Sci 85:103-44. 2000
    ..Finally, the first reported measurements of the dynamic surface excess Gamma(t), using the overflowing cylinder in conjunction with neutron reflection, are described...
  53. ncbi Correlation between thermal aggregation and stability of lysozyme with salts described by molar surface tension increment: an exceptional propensity of ammonium salts as aggregation suppressor
    Atsushi Hirano
    Institute of Applied Physics, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, 305 8573, Japan
    Protein J 26:423-33. 2007
    ..The positive relation between aggregation rate and T (m) was described by another factor such as the surface tension of salt solutions...
  54. ncbi Dependence of lung injury on surface tension during low-volume ventilation in normal open-chest rabbits
    Edgardo D'Angelo
    Istituto di Fisiologia Umana I, Universita di Milano, Milan, Italy
    J Appl Physiol (1985) 102:174-82. 2007
    ....
  55. ncbi Phospholipase A2 is present in meconium and inhibits the activity of pulmonary surfactant: an in vitro study
    A J Schrama
    Department of Pediatrics, Leiden University Medical Center, The Netherlands
    Acta Paediatr 90:412-6. 2001
    ..Also, their effect on the surface tension of surfactant (Curosurf) was measured using a pulsating bubble surfactometer (PBS)...
  56. ncbi Interface properties of simplified tear-like fluids in relation to lipid and aqueous layers composition
    Fausto Miano
    SIFI S p A Lavinaio CT, Italy
    Adv Exp Med Biol 506:405-17. 2002
    ..We may also couple different techniques such as measuring elastic and rheological properties of the films that may be relevant to its physiological behaviour...
  57. ncbi Critical exponents for line tension and dipole density difference from lipid monolayer domain boundary fluctuations
    Michael C Heinrich
    Department of Chemistry, Institute for Medicine and Engineering, and Laboratory for Research on the Structure of Matter, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104, USA
    J Phys Chem B 112:8063-8. 2008
    ..Additionally, photobleaching effects and domain size influence were quantified and found to be small in our system. We suggest that the method of flicker spectroscopy can be helpful in identifying line-active compounds...
  58. pmc Hybrid lipids as a biological surface-active component
    R Brewster
    Weizmann Institute of Science, Department of Materials and Interfaces, Rehovot, Israel
    Biophys J 97:1087-94. 2009
    ..In this limit, finite-sized domains stabilized by the packing of these hybrid lipids can form as equilibrium structures...
  59. pmc Axisymmetric drop shape analysis for estimating the surface tension of cell aggregates by centrifugation
    Ali Kalantarian
    Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada
    Biophys J 96:1606-16. 2009
    Biological tissues behave in certain respects like liquids. Consequently, the surface tension concept can be used to explain aspects of the in vitro and in vivo behavior of multicellular aggregates...
  60. ncbi Spontaneous, oscillatory liquid transport in surface tension-confined microfluidics
    Shih Hui Chao
    Center for Ecogenomics, The Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA
    Lab Chip 9:867-9. 2009
    ..A unique, spontaneous, oscillatory flow phenomenon driven by the Marangoni effect on a heterogeneous surface can be used for passive microfluidic pumping...
  61. ncbi On the role of surface tension in the pathophysiology of emphysema
    Edward P Ingenito
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 171:300-4. 2005
  62. ncbi Surface properties of sulfur- and ether-linked phosphonolipids with and without purified hydrophobic lung surfactant proteins
    Yusuo Chang
    Department of Pediatrics, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Chem Phys Lipids 137:77-93. 2005
    ..The high activity and inhibition resistance of synthetic surfactants containing DEPN-8 or SO(2)-lipid plus SP-B/SP-C are promising for future applications in treating surfactant dysfunction in inflammatory lung injury...
  63. ncbi Surface tension in tears
    J M Tiffany
    Arch Soc Esp Oftalmol 81:363-6. 2006
  64. ncbi Dynamic surface tension behavior in a photoresponsive surfactant system
    Bradley A Cicciarelli
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Langmuir 23:4753-64. 2007
    ..illumination conditions (dark, UV light, visible light), freshly formed surfaces exhibit profoundly different surface tension trajectories as they approach essentially identical equilibrium states...
  65. ncbi Synthesis and surface activity of diether-linked phosphoglycerols: potential applications for exogenous lung surfactants
    Robert H Notter
    Department of Pediatrics, University of Rochester, Rochester, NY 14642, USA
    Bioorg Med Chem Lett 17:113-7. 2007
    ..The surface tension-lowering capabilities of synthetic lung surfactant mixtures containing the PG analogs were measured on the ..
  66. ncbi Mapping and analysis of the lytic and fusogenic domains of surfactant protein B
    Marnie A Ryan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Biochemistry 44:861-72. 2005
    ..The requirements for optimal surface tension reduction were similar to those for fusion; in contrast, helix 1 (residues 7-22) alone was sufficient for ..
  67. ncbi Testing the role of solvent surface tension in protein ionization by electrospray
    Maria Samalikova
    Institute of Organic Chemistry, Johannes Kepler University, Altenbergerstrasse 69, A 4040 Linz, Austria
    J Mass Spectrom 40:503-10. 2005
    This work was aimed at probing the influence of solvent surface tension on protein ionization by electrospray...
  68. ncbi The "wisdom" of lung surfactant: balancing host defense and surface tension-reducing functions
    Jo Rae Wright
    Box 3709, Dept of Cell Biology, Duke Univ Medical Center, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 291:L847-50. 2006
  69. ncbi Single molecular anatomy of solvophobic effects in host-guest interactions based on surface tension using atomic force microscopy
    Satoshi Yasuda
    Institute of Applied Physics, 21st Century COE, CREST JST, University of Tsukuba, Tsukuba, Ibaraki 305 8573, Japan
    Phys Rev Lett 96:228303. 2006
    The effectiveness of the mechanism of surface tension to analyze the host-guest interaction was demonstrated by measuring the unbinding force of the beta-Cyclodextrin (CyD)--adamantane molecules in a liquid environment at the single-..
  70. ncbi Domains of surfactant protein A that affect protein oligomerization, lipid structure and surface tension
    N Palaniyar
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, OX1 3QU, Oxford, UK
    Comp Biochem Physiol A Mol Integr Physiol 129:109-27. 2001
    ..In recent work, we have determined that the maintenance of low surface tension of surfactant in the presence of serum protein inhibitors requires cooperative interactions between the C-..
  71. ncbi Polymyxin B/pulmonary surfactant mixtures have increased resistance to inactivation by meconium and reduce growth of gram-negative bacteria in vitro
    Guido Stichtenoth
    Department of Clinical Chemistry, Laboratory for Surfactant Research, Karolinska Hospital, Sweden
    Pediatr Res 59:407-11. 2006
    ..Curosurf plus CaCl2/PxB needed a 4-fold increase of meconium concentration to increase dynamic surface tension significantly compared with Curosurf plus CaCl2 alone, indicating that PxB further increases the resistance ..
  72. pmc Morphological alterations of exogenous surfactant inhibited by meconium can be prevented by dextran
    Matthias Ochs
    Institute of Anatomy, Experimental Morphology, University of Bern, Baltzerstrasse 2, CH 3012 Bern, Switzerland
    Respir Res 7:86. 2006
    ..Morphological surfactant analysis by transmission electron microscopy (TEM) and stereology allows the differentiation of active (large aggregates = LA) and inactive (small aggregates = SA) subtypes...
  73. ncbi Simple model for prediction of surface tension of mixed surfactant solutions
    V B Fainerman
    International Medical Physicochemical Centre, Donetsk Medical University, Donetsk, Ukraine
    Adv Colloid Interface Sci 96:339-59. 2002
    ..The agreement between experimental data and the theoretical calculations is excellent. This approach can be especially important for practical applications of surfactant mixtures for which experimental data are scarce...
  74. pmc On simulating lipid bilayers with an applied surface tension: periodic boundary conditions and undulations
    S E Feller
    Biophysics Laboratory, Food and Drug Administration, Rockville, Maryland 20852 1448, USA
    Biophys J 71:1350-5. 1996
    ..Such fluctuations are intrinsically connected to the value of the macroscopic (or thermodynamic) surface tension (cf. Eqs. 1 and 9; for a related treatment, see Brochard et al., 1975, 1976)...
  75. ncbi Bronchoscopic administration of bovine natural surfactant in ARDS and septic shock: impact on biophysical and biochemical surfactant properties
    A Gunther
    Dept of Internal Medicine II, Justus Liebig University, Giessen, Germany
    Eur Respir J 19:797-804. 2002
    ..Both minimum (gammamin) and adsorption (gammaads) surface tension values (pulsating bubble surfactometer) were dramatically increased...
  76. ncbi In situ synthesis of oligonucleotide arrays by using surface tension
    J H Butler
    GenePharm Inc, 136 South Wolfe Road, Sunnyvale, CA 94086, USA
    J Am Chem Soc 123:8887-94. 2001
    ..These arrays are composed of features defined and separated by differential surface tension (surface tension arrays)...
  77. ncbi Effects of surface tension and viscosity on airway reopening
    D P Gaver
    Section of Pulmonary and Critical Care Medicine, University of Chicago, Illinois 60637
    J Appl Physiol (1985) 69:74-85. 1990
    ..Using dimensional analysis, we found that the relative importance of viscous and surface tension forces depends on the capillary number (Ca = microU/gamma)...
  78. ncbi Rapid method for measurement of surface tension in multiwell plates
    Matthew G Cottingham
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Lab Invest 84:523-9. 2004
    We describe an optical method for quantifying surface tension in 96-well microtitre plates...
  79. ncbi Cardiac looping in experimental conditions: effects of extraembryonic forces
    Dmitry A Voronov
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Dev Dyn 224:413-21. 2002
    ..Such preparations, however, expose the embryo and the heart to surface tension that is not present in ovo...
  80. ncbi In vivo determination of surface tension in the horse trachea and in vitro model studies
    V Im Hof
    Department of Internal Medicine, University Hospital, Inselspital, Berne, Switzerland
    Respir Physiol 109:81-93. 1997
    We measured the surface tension in the trachea of the non-anaesthetised horse from the spreading behaviour of fluid drops, using videotracheoscopy...
  81. ncbi Mechanical ventilation of isolated rat lungs changes the structure and biophysical properties of surfactant
    Ruud A W Veldhuizen
    Lawson Health Research Institute and Department of Physiology, University of Western Ontario, London, Ontario, Canada N6A 4V2
    J Appl Physiol (1985) 92:1169-75. 2002
    ..of the biophysical properties by using a captive bubble surfactometer demonstrated that adsorption and surface tension reduction were significantly impaired with LA from the injuriously ventilated lungs...
  82. ncbi Surfactant in the middle ear and eustachian tube: a review
    John F McGuire
    School of Medicine, Georgetown University, 2908 B O Street NW, Washington, DC 20007, USA
    Int J Pediatr Otorhinolaryngol 66:1-15. 2002
    ..four platforms of research: the role of surfactant in the innate immune system, the effect of surfactant on surface tension and Eustachian tube opening pressure, the capacity of surfactant to alter the rheological properties of mucus ..
  83. ncbi Constant-pressure and constant-surface tension simulations in dissipative particle dynamics
    Ask F Jakobsen
    MEMPHYS Center for Biomembrane Physics, Physics Department, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    J Chem Phys 122:124901. 2005
    We present a method for constant-pressure and constant-surface tension simulations in dissipative particle dynamics using a Langevin piston approach...
  84. pmc Adsorption of frog foam nest proteins at the air-water interface
    Alan Cooper
    Department of Chemistry, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Biophys J 88:2114-25. 2005
    ..ranaspumins) from the foam nests of the tropical frog Physalaemus pustulosus have been investigated by surface tension, two-photon excitation fluorescence microscopy, specular neutron reflection, and related biophysical ..
  85. ncbi Temperature dependence of blood surface tension
    J Rosina
    Department of Medical Biophysics and Medical Informatics, Third Medical Faculty, Charles University, Prague, Czech Republic
    Physiol Res 56:S93-8. 2007
    Whole blood surface tension of 15 healthy subjects recorded by the ring method was investigated in the temperature range from 20 to 40 degrees C...
  86. ncbi Surface tension controls capsule thickness and collagen orientation in glaucoma shunt devices
    O A Kadri
    Department of Biology, U.S. Air Force Academy, CO 80840, USA
    Biomed Sci Instrum 37:257-62. 2001
    ..Previous studies suggested that fibers orient along the principal stress lines--surface tension on the capsule directs collagen growth in order to strengthen the stretched membrane...
  87. ncbi Surface pressure measurements of human tears and individual tear film components indicate that proteins are major contributors to the surface pressure
    Sophia T Tragoulias
    Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, Australia
    Cornea 24:189-200. 2005
    Tear film stability has been associated with a low surface tension (high surface pressure), which has been attributed to a variety of tear film components...
  88. pmc Particle-induced indentation of the alveolar epithelium caused by surface tension forces
    S M Mijailovich
    Molecular and Integrative Physiological Sciences, Dept of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Bldg I, Rm 1010D, Boston, MA 02115, USA
    J Appl Physiol (1985) 109:1179-94. 2010
    ..operating in the particle-tissue interaction phenomena can be explained on the basis of a balance between surface tension force and tissue resistance force; the former tend to move a particle toward alveolar epithelial cell surface,..
  89. ncbi Surfactant alterations in severe pneumonia, acute respiratory distress syndrome, and cardiogenic lung edema
    A Gunther
    Department of Internal Medicine, Justus Liebig University, Giessen, Germany
    Am J Respir Crit Care Med 153:176-84. 1996
    ..We conclude that pronounced surfactant abnormalities, comparable to those in ARDS in the absence of lung infection, occur in different entities of severe PNEU, but not in CLE...
  90. ncbi Bilirubin influence on oxidative lung damage and surfactant surface tension properties
    Carlo Dani
    Section of Neonatology, Department of Surgical and Medical Critical Care, University of Florence, Florence, Italy
    Pediatr Pulmonol 38:179-85. 2004
    ..that hyperbilirubinemia might reduce in vivo oxidative lung damage while also diminishing lung surfactant surface tension properties during acute lung injury, we performed a randomized study in a rabbit model of acute lung injury...
  91. pmc Thermodynamic effects of the hydrophobic surfactant proteins on the early adsorption of pulmonary surfactant
    V Schram
    Departments of Biochemistry and Molecular Biology, Medicine, and Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97201-3098, USA
    Biophys J 81:1536-46. 2001
    ..We compared the temperature and concentration dependence of adsorption, measured by monitoring surface tension, between calf lung surfactant extract (CLSE) and the complete set of neutral and phospholipids (N&PL) ..
  92. ncbi Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease
    H Matsui
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, 27599 7248, USA
    Cell 95:1005-15. 1998
    ..These data indicate that therapy for CF lung disease should not be directed at modulation of ionic composition, but rather at restoring volume (salt and water) on airway surfaces...
  93. ncbi Pulmonary surfactant in birds: coping with surface tension in a tubular lung
    W Bernhard
    Departments of Pediatric Pulmonology and Neonatology, Hannover Medical School, 30625 Hannover, Germany
    Am J Physiol Regul Integr Comp Physiol 281:R327-37. 2001
    ..with pig surfactant, both bird surfactants were enriched in dipalmitoylphosphatidylcholine, the principle surface tension-lowering agent in surfactant, and depleted in palmitoylmyristoylphosphatidylcholine, the other disaturated ..
  94. ncbi The effect of dextran to restore the activity of pulmonary surfactant inhibited by albumin
    J J Lu
    Department of Mechanical and Industrial Engineering, University of Toronto, 5 King s College Road, Toronto, Ont, Canada M5S 3G8
    Respir Physiol Neurobiol 130:169-79. 2002
    ..It was found that dextran could effectively restore surface tension properties of the inhibited surfactant in vitro...
  95. ncbi Dextran restores albumin-inhibited surface activity of pulmonary surfactant extract
    T Kobayashi
    Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University, Kanazawa 920 8641, Japan
    J Appl Physiol (1985) 86:1778-84. 1999
    ..01). The minimum surface tension of 2...
  96. ncbi Surfactant subtype conversion is related to loss of surfactant apoprotein B and surface activity in large surfactant aggregates. Experimental and clinical studies
    A Gunther
    Departments of Internal Medicine and Anatomy, Justus Liebig University Giessen, Giessen, Germany
    Am J Respir Crit Care Med 159:244-51. 1999
    ..of LA to SA was accompanied by a marked decline in the ability of the remaining LA fraction to reduce surface tension by adsorption and during film compression on a pulsating bubble surfactometer...
  97. pmc Box-Behnken experimental design in the development of a nasal drug delivery system of model drug hydroxyurea: characterization of viscosity, in vitro drug release, droplet size, and dynamic surface tension
    Pankaj Dayal
    Division of Pharmaceutics, College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, FL 32307, USA
    AAPS PharmSciTech 6:E573-85. 2005
    ..The rheology and dynamic surface tension (DST) of the test formulations was investigated using LV-DV-III Brookfield rheometer and T60 SITA tensiometer,..
  98. ncbi Nonionic polymers reverse inactivation of surfactant by meconium and other substances
    H William Taeusch
    Departments of Pediatrics and Physiology, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA
    Am J Respir Crit Care Med 159:1391-5. 1999
    A variety of substances including human meconium have been found to affect adversely the surface tension-lowering activity of pulmonary surfactants, and this effect may be important in the pathogenesis of a number of human diseases...
  99. ncbi Effect of interactions between the adsorbed species on the properties of single and mixed-surfactant monolayers at the air/water interface
    Stoyan I Karakashev
    Faculty of Chemistry, St Kliment Ohridski University of Sofia, Sofia, 1126, Bulgaria
    J Colloid Interface Sci 248:477-86. 2002
    Experimental data on surface tension available from the literature and generated in the present study are analyzed to estimate the applicability of adsorption models, based on the Frumkin equation, to nonionic and ionic surfactants and ..
  100. ncbi The influence of subphase temperature on miltefosine-cholesterol mixed monolayers
    J Miñones
    Department of Physical Chemistry, Faculty of Pharmacy, Campus Sur, 15706 Santiago de Compostela, Spain
    J Colloid Interface Sci 301:258-66. 2006
    ..Such "surface complexes" should be responsible for the contraction of the mean molecular area and thus the high stability of the mixed monolayer...
  101. ncbi Substrate and surfactant effects on the glass-liquid transition of thin water films
    Ryutaro Souda
    Nanoscale Materials Center, National Institute for Materials Science, 1 1 Namiki, Tsukuba, Ibaraki 305 0044, Japan
    J Phys Chem B 110:17524-30. 2006
    ..This is because the morphology of supercooled liquid water is changed by the surface tension, and it is quenched by termination of the free OH groups on the surface...

Research Grants62

  1. MECHANISMS IN THE REGULATION OF SP-A GENE EXPRESSION
    Carole R Mendelson; Fiscal Year: 2013
    ..Pulmonary surfactant, a developmentally regulated lipoprotein synthesized in alveolar type II cells, reduces surface tension within the lung alveolus and is essential for normal breathing...
  2. Lipid Droplet Metabolism
    Fredric B Kraemer; Fiscal Year: 2013
    ..This hypothesis will be tested using specialized equipment to measure the viscoelastic properties (viscosity, surface tension, etc...
  3. Anionic Surfactant Lipid Regulation of Inflammation and Infection in the Lung
    Dennis R Voelker; Fiscal Year: 2013
    ..surfactant system of the lung is a lipid and protein complex that plays a central role in regulating the surface tension of the alveolar compartment and controlling innate immunity...
  4. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard B Weinberg; Fiscal Year: 2010
    ..We have proposed that this behavior enables apo A-IV to act as a barostat that maintains lipoprotein surface tension and lipid packing within a critical range required for lipid transfer reactions...
  5. Hormonal Regulation of Surfactant Protein mRNA Stability
    Joseph L Alcorn; Fiscal Year: 2012
    ..by applicant): The synthesis of pulmonary surfactant, a lipoprotein complex that acts to reduce lung alveolar surface tension, is developmentally and hormonally regulated in fetal lung tissue...
  6. Pulmonary Surfactant and Lung Homeostasis
    John R Perfect; Fiscal Year: 2012
    In addition to reducing surface tension in the lung, surfactant proteins SP-A and SP-D have important immunomodulatory functions...
  7. LIPID AND PROTEIN EFFECTS ON MONOLAYER STABILITY
    JOSEPH ANTHONY ZASADZINSKI; Fiscal Year: 2013
    ..lung surfactants, reduce the surface shear viscosity by orders of magnitude, without altering the minimum surface tension. We have found that cholesterol separates into a disordered "interphase" that reduces the line tension ..
  8. Antibacterial Perfluorocarbon Ventilation to Treat Severe Respiratory Infections
    KEITH ELLIOT COOK; Fiscal Year: 2013
    ..the tidal flow of PFCs actively removes infected mucus from airway walls due to fluid shear and reduced mucus surface tension. The mucus is then convectively transported from the lungs, aided by buoyant force, and removed easily from ..
  9. Stability of Pullmonary Airways
    JAMES BERNARD GROTBERG; Fiscal Year: 2010
    ..Closure results from a surface tension instability that tends to pull the airway to a smaller diameter while potentially driving the liquid lining ..
  10. Improving Inhaled Drug Delivery with Self-dispersing Liquids
    STEPHEN GAROFF; Fiscal Year: 2013
    ..that adding certain surfactants (amphiphilic molecules that adsorb to and spread over liquid surfaces) or low surface tension fluids to inhaled medications will promote the formation of self-dispersing medicated films in the lung...
  11. LPCAT1 is essential for perinatal lung function and survival
    John M Shannon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The air-liquid interface in the lung is a region of high surface tension that, if unmodified, causes alveolar collapse and respiratory failure...
  12. Cardiolipin Induced Lung Injury and FIC1
    Rama K Mallampalli; Fiscal Year: 2013
    ....
  13. Membrane Mechanics, Osmotic Stress, and the Yeast Stretch-Activated TRP
    Yoshiro Saimi; Fiscal Year: 2010
    ..interface centers between the charged lipid head and the hydrophobic tail of the lipid bilayer, a point where surface tension is the highest...
  14. INTERFACIAL ADSORPTION OF PULMONARY SURFACTANT
    Stephen B Hall; Fiscal Year: 2010
    Pulmonary surfactant lowers surface tension in the lungs...
  15. Using deep-cavity cavitands to study supramolecular chemistry in water
    Bruce C Gibb; Fiscal Year: 2013
    ..to build the first thermodynamic models of the Hofmeister Effect at the molecular level, and has the potential to unify current models of the Hofmeister Effect based on bulk properties such as solubility, viscosity, and surface tension.
  16. Improved ventilation of the edematous lung
    Carrie E Perlman; Fiscal Year: 2013
    ..We have developed a novel method for determining surface tension in edematous alveoli, enabling in situ assessment of the effect of additives on interfacial surface tension...
  17. RADIOPAQUE FLUOROCARBON IN DIAGNOSTIC RADIOLOGY
    David Long; Fiscal Year: 1980
    ..The RFC's are chemically stable and biologically inert and safe. Because of their low surface tension and low viscosity, fluorocarbon liquids coat surfaces readily and rapidly...
  18. Biomechanical Evaluation of Eustachian Tube Dysfunction
    Samir N Ghadiali; Fiscal Year: 2010
    ..e. surface tension and mucosal adhesion forces) influence ET opening...
  19. LIQUID VENTILATION IN ARDS
    Ronald Hirschl; Fiscal Year: 2000
    ..Perfluorocarbons are inert, colorless, high-density, low surface tension liquids which carry large quantities of oxygen and carbon dioxide...
  20. Unexpectedly Profound Role of Water in Biology and Medicine
    Gerald H Pollack; Fiscal Year: 2013
    ..Do the above-mentioned features play a central role? (2) Surface tension and oxygen exchange...
  21. DEVELOPMENT OF DNA MICROARRAY FABRICATION METHOD
    Maureen Cronin; Fiscal Year: 1999
    ..Our system combines drop-on-demand inkjet reagent delivery with a chemically modified substrate. Surface tension constrains active chemistry to predefined locations...
  22. INTERFACIAL ADSORPTION OF PULMONARY SURFACTANT
    Stephen Hall; Fiscal Year: 1999
    ..pulmonary surfactant adsorbs rapidly to an air-liquid interface to form interfacial films capable of reducing surface tension during compression...
  23. GLUTATHIONE PROTECTION AGAINST HYPEROXIC INJURY IN LUNG
    Dean Jones; Fiscal Year: 1993
    DESCRIPTION: (Adapted from the applicant's abstract.) Pulmonary surfactant is a complex that reduces surface tension at the air-liquid interface and plays a crucial role in neonatal adaptation...
  24. PULMONARY SURFACTANT DYNAMICS AND SURFACTANT PROTEIN A
    DENNIS VOELKER; Fiscal Year: 2000
    ..a lipid and protein complex present in the alveolus that greatly diminishes the work of breathing by reducing surface tension at athe air-liquid interface...
  25. ANNEXINS AND LUNG SURFACTANT SECRETION
    Lin Liu; Fiscal Year: 1999
    Pulmonary surfactant lines the lung epithelium and lowers surface tension to prevent collapse at end-expiration. It is synthesized in epithelial type II cells and stored in lamellar bodies...
  26. BILIRUBIN ENCEPHALOPATHY: ROLE OF MONOVALENT ANION
    Richard Wennberg; Fiscal Year: 1992
    ..In vitro studies will document the influence of bilirubin on surface tension in aqueous solutions and investigate determinants of water/non-aqueous solvent partitioning...
  27. SURFACTANT PROTEINS AND LUNG INFLAMMATION
    Kelly Greene; Fiscal Year: 2000
    ..modulators of host defense and alveolar inflammation, in addition to their role in reducing alveolar surface tension. Lung inflammation is characterized by elevated neutrophil and interleukin-8 (IL-8) concentrations in BAL ..
  28. SPECTROSCOPY OF BIOMEMBRANE MONOLAYERS
    Richard Dluhy; Fiscal Year: 2006
    ..by applicant): Pulmonary surfactant is an integral component of mammalian alveoli that serves to reduce surface tension and promote oxygen uptake in the lung...
  29. Pneumedoreductive Surfacant - New Therapy for Emphysema
    Edward Ingenito; Fiscal Year: 2004
    ..Two factors determine lung elastic recoil: 1) stretching of the tissue fiber network and 2) surface tension generated by the surface film at the alveolar air-liquid interface...
  30. DOES PULMONARY SURFACTANT REACT WITH INHALED POLLUTANTS?
    BARBARA FINLAYSON PITTS; Fiscal Year: 1993
    ..occurs, the alveoli are lined with a liquid layer containing pulmonary surfactant (PS) which lowers the surface tension by alignment at the air-water interface...
  31. SUB-MICROLITER, HIGH THROUGHPUT THERMAL CYCLER
    Andre Marziali; Fiscal Year: 2002
    ..Consequently, the surface tension limitations associated with small volume pipetting are avoided and sub microliter reactions are pipetted ..
  32. SURFACTANT PROTEIN A IN PULMONARY HOST DEFENSE
    Francis McCormack; Fiscal Year: 2002
    ..pulmonary surfactant, a mixture of phospholipids and proteins that maintains alveolar patency by reducing surface tension forces at the dir-liquid interface...
  33. C/EBP AND ALVEOLAR TYPE II CELL DIFFERENTIATION
    SHELDON FEINSTEIN; Fiscal Year: 2000
    ..are involved in the synthesis of pulmonary surfactant, a complex of lipids and proteins which lowers surface tension preventing alveolar collapse...
  34. Precursor Preference in Surfactant Synthesis of Newborns
    Kimberly Spence; Fiscal Year: 2004
    Pulmonary surfactant, a mixture of phospholipid and protein, stabilizes lungs by lowering surface tension and preventing alveolar collapse at end expiration...
  35. Simplified Total Liquid Ventilator
    Kathryn Osterholzer; Fiscal Year: 2002
    ..Periluorocarbons are inert, colorless, low surface tension liquids that can carry large quantities of oxygen and carbon dioxide...
  36. MOLECULAR PROPERTIES OF NA+ CHANNELS IN LUNG ATII CELLS
    Dale Benos; Fiscal Year: 1999
    ..especially under pathological conditions in which the pulmonary surfactant system has been compromised and surface tension increases, the information obtained from this work may eventually have important implications in the ..
  37. POLYMERS WITH STEP-WISE VARIABLE SURFACE COMPOSITION
    Robert Ward; Fiscal Year: 2002
    ..In Phase we confirmed that, while rates are slower, equilibrium surface tension/composition of polymer blends is quantitatively similar to conventional surfactants in liquid Solvents...
  38. ALVEOLAR SURFACE FORCES EFFECTS ON LUNG FUNCTION
    James Butler; Fiscal Year: 2000
    ..Experiments will be done in anesthetized sheep and in excised lungs with surface tension alterations caused by saline lavage, rinses with constant surface tension oils, and oleic acid administration ..
  39. Electrostatic Formation and Transport of Small Droplets
    Thomas Jones; Fiscal Year: 2002
    ..elucidate these dynamics, varying the important parameters of electrode configuration, voltage waveform, and surface tension, as well as analytic and computer modeling of the processes involved...
  40. PULMONARY MASS AND HEAT TRANSPORT
    James Grotberg; Fiscal Year: 1991
    ..theoretical analysis of how a liquid droplet (an aerosol) spreads on a thin liquid film (lung's lining) from surface tension effects...
  41. DEVELOPMENT OF A BIOPOLYMER BASED TEAR FILM SUPPLEMENT
    Edward Ellis; Fiscal Year: 1999
    ..ophthalmic solution and characterize with respect to accepted ranges of viscosity, osmolality, pH and surface tension. PROPOSED COMMERCIAL APPLICATION The approximately 100 million dollars dry eye product market is expected to ..
  42. The Host Response to Calfactant for Direct Acute Lung Injury in Critically Ill Ch
    Derek Wheeler; Fiscal Year: 2009
    ..Surfactant functions to decrease surface tension during normal tidal breathing and is an integral part of the innate lung defense...
  43. Engineering Ventilation Waveforms to Reduce Atelectrauma
    Donald Gaver; Fiscal Year: 2009
    ..In RDS and potentially ARDS, the lining fluid surface tension is elevated due to surfactant deficiency, which increases the pressure necessary to open the occluded airways...
  44. PROTEINS IN MOLECULAR MECHANISMS OF TEAR FILM FORMATION
    BEN GLASGOW; Fiscal Year: 2000
    ..Specific Aim I: To elucidate the role of lipocalins in formation of the tear surface film. A. The surface tension contribution of dilapidated and lipidated lipocalins will be measured in aqueous media...
  45. De Novo Design of Lung Surfactant Protein B Mimics
    TICORA JONES; Fiscal Year: 2003
    ..This protein is crucial for the expansion and contraction of the alveoli in the lungs as it reduces surface tension and allows for the gas exchange that occurs during respiration...
  46. Bioemulsifying Vaccine Delivery System for Immunomodulation
    David Kaplan; Fiscal Year: 2009
    ..g., emulsification, surface tension) and biological function (e.g., macrophage activation such as TNF.)...
  47. Microbiological Air Contamination from Machining Fluids
    Tiina Reponen; Fiscal Year: 2002
    ..will be adopted and modified for this study, and will be used with MWFs representing different viscosity and surface tension. The aerosolization of mist will be tested first with clean fluids, with fluids inoculated with known ..
  48. Electrowetting Droplet Microfluidics for Biochips
    MICHAEL EMERLING; Fiscal Year: 2003
    ..utilizes the most dominant physical force that is present in microfluidic sample handling: interfacial surface tension. Tanner Research, Inc...
  49. PULMONARY MASS AND HEAT TRANSPORT
    James Grotberg; Fiscal Year: 2002
    ..theoretical modelling will allow us to infer physical properties of the liquid lining (thickness, viscosity, surface tension) in airways and in alveoli...
  50. MECHANOREGULATION OF ALVEOLAR CELL PHENOTYPIC EXPRESSION
    Jorge Gutierrez; Fiscal Year: 2004
    ..characterized by lamellar bodies containing surfactant components, which are responsible for lowering surface tension at the alveolar air-liquid interface, preventing alveolar collapse...
  51. Droplet Cell Array Assays
    GREGORY FARIS; Fiscal Year: 2007
    ..We use laser light to induce surface tension gradients, which allows us to selectively move very small individual droplets (mu L-pL), and we have ..
  52. MOLECULAR MECHANISMS OF LUNG SURFACTANT SECRETION
    Lin Liu; Fiscal Year: 2007
    Lung surfactant is critical in reducing surface tension and maintaining normal functions of lungs...
  53. Pneumoreductive Surfactant Therapy for Emphysema
    Edward Ingenito; Fiscal Year: 2007
    ..PRSs are inhaled drugs that increase lung recoil by safely altering the surface tension properties of native lung surfactant...
  54. INTEGRATION OF FTIR AND A CAPTIVE BUBBLE SURFACTOMETER
    JOHN BAATZ; Fiscal Year: 2000
    ..FTIR spectral acquisition in the CBS/ATR-FTIR sample chamber, to optimize parameters and instrumentation for surface tension measurements by the CBS component, and to integrate all components of the CBS/ATR-FTIR sampling accessory for ..
  55. Lagrangian detection of biomolecular interactions
    FREDERICK HASELTON; Fiscal Year: 2005
    ..appropriate fiber, deposition of probe, development of the small volume reaction compartment with immiscible surface tension valves, and a specialized apparatus for computer controlled fiber transport through multiple reaction ..
  56. NEUTROPHIL INJURY TO ALVEOLAR TYPE II CELLS
    Courtney Crim; Fiscal Year: 1990
    ..3) measuring the activity of several enzymes involved in surfactant biosynthesis; 4) determination of minimal surface tension and hysteresis profiles of surfactant released from injured type II cells...
  57. ABCA3 and Alveolar Homeostasis
    Jeffrey A Whitsett; Fiscal Year: 2010
    ....
  58. CYTOMIMETIC ORGANIC CHEMISTRY
    FREDRIC MENGER; Fiscal Year: 2007
    ....
  59. PERINATAL EXPRESSION OF SURFACTANT PROTEIN GENE SP-B
    Jeffrey Whitsett; Fiscal Year: 2007
    ..Transcriptional responses to decreased SP-B will be determined using RNA microarray, to identify the molecular pathways mediating or compensating for reduced SP-B/surfactant function in vivo. [unreadable] [unreadable]..
  60. SHH and Alveolar Formation
    Jeffrey Whitsett; Fiscal Year: 2006
    ..abstract_text> ..
  61. Transcriptional Control of Respiratory Epithelial Progenitor Cells
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..A Stem Cell Consortium will be established at CCHMC, Univ. of Cincinnati College of Medicine to develop education, training, and research bridging hematopoietic stem cell and pulmonary stem cell biology on our campus. ..