Top Publications

  1. ncbi Frictional adhesion: A new angle on gecko attachment
    K Autumn
    Department of Biology, Lewis and Clark College, 0615 SW Palatine Hill Road, Portland, OR 97219, USA
    J Exp Biol 209:3569-79. 2006
  2. ncbi Mixed-mode failure strength of implant-cement interface specimens with varying surface roughness
    J Zelle
    Orthopaedic Research Laboratory, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Biomech 44:780-3. 2011
  3. ncbi Bond strengths of orthodontic bracket after acid-etched, Er:YAG laser-irradiated and combined treatment on enamel surface
    Bor Shiunn Lee
    Graduate Institute of Clinical Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan ROC
    Angle Orthod 73:565-70. 2003
  4. ncbi Mucoadhesive polymeric platforms for controlled drug delivery
    Gavin P Andrews
    School of Pharmacy, The Queen s University of Belfast, Belfast, Ireland
    Eur J Pharm Biopharm 71:505-18. 2009
  5. pmc Resolving the nanoscale adhesion of individual gecko spatulae by atomic force microscopy
    Gerrit Huber
    Max Planck Institut für Metallforschung Heisenbergstrasse 3, D 70569 Stuttgart, Germany
    Biol Lett 1:2-4. 2005
  6. ncbi Calcium oxalate crystal adherence to hyaluronan-, osteopontin-, and CD44-expressing injured/regenerating tubular epithelial cells in rat kidneys
    Marino Asselman
    Department of Urology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    J Am Soc Nephrol 14:3155-66. 2003
  7. ncbi The surface physicochemistry and adhesiveness of Shewanella are affected by their surface polysaccharides
    Anton Korenevsky
    Department of Molecular and Cellular Biology and Advanced Foods and Materials Network Networks of Centres of Excellence, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Microbiology 153:1872-83. 2007
  8. ncbi An in vitro comparison of the intraradicular dentin bond strength of Resilon and gutta-percha
    Lance J Skidmore
    Department of Endodontics, Marquette University, School of Dentistry, Milwaukee, Wisconsin 53233, USA
    J Endod 32:963-6. 2006
  9. pmc Evidence for self-cleaning in gecko setae
    W R Hansen
    Department of Physics and Biology, Lewis and Clark College, Portland, OR 97219, USA
    Proc Natl Acad Sci U S A 102:385-9. 2005
  10. pmc AtaA, a new member of the trimeric autotransporter adhesins from Acinetobacter sp. Tol 5 mediating high adhesiveness to various abiotic surfaces
    Masahito Ishikawa
    Department of Biotechnology, Graduate School of Engineering, Nagoya University, Furo cho, Chikusa ku, Japan
    PLoS ONE 7:e48830. 2012

Detail Information

Publications236 found, 100 shown here

  1. ncbi Frictional adhesion: A new angle on gecko attachment
    K Autumn
    Department of Biology, Lewis and Clark College, 0615 SW Palatine Hill Road, Portland, OR 97219, USA
    J Exp Biol 209:3569-79. 2006
    ..The frictional adhesion model provides an explanation for the very low detachment forces observed in climbing geckos that does not depend on toe peeling...
  2. ncbi Mixed-mode failure strength of implant-cement interface specimens with varying surface roughness
    J Zelle
    Orthopaedic Research Laboratory, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Biomech 44:780-3. 2011
    ..The findings presented in this paper can be used in numerical models to simulate loosening at the implant-cement interface...
  3. ncbi Bond strengths of orthodontic bracket after acid-etched, Er:YAG laser-irradiated and combined treatment on enamel surface
    Bor Shiunn Lee
    Graduate Institute of Clinical Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan ROC
    Angle Orthod 73:565-70. 2003
    ..Er:YAG laser ablation consumed less time compared with the acid-etching technique. Therefore, Er:YAG laser ablation can be an alternative tool to conventional acid etching...
  4. ncbi Mucoadhesive polymeric platforms for controlled drug delivery
    Gavin P Andrews
    School of Pharmacy, The Queen s University of Belfast, Belfast, Ireland
    Eur J Pharm Biopharm 71:505-18. 2009
    ..Evolution of such mucoadhesive formulations has transgressed from first-generation charged hydrophilic polymer networks to more specific second-generation systems based on lectin, thiol and various other adhesive functional groups...
  5. pmc Resolving the nanoscale adhesion of individual gecko spatulae by atomic force microscopy
    Gerrit Huber
    Max Planck Institut für Metallforschung Heisenbergstrasse 3, D 70569 Stuttgart, Germany
    Biol Lett 1:2-4. 2005
    ..This method sheds new light on the nanomechanisms of attachment and will help in the rational design of artificial attachment systems...
  6. ncbi Calcium oxalate crystal adherence to hyaluronan-, osteopontin-, and CD44-expressing injured/regenerating tubular epithelial cells in rat kidneys
    Marino Asselman
    Department of Urology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    J Am Soc Nephrol 14:3155-66. 2003
    ..In conclusion, the expression of HA, OPN, and CD44 by injured/regenerating tubular cells seems to play a role in retention of crystals in the rat kidney...
  7. ncbi The surface physicochemistry and adhesiveness of Shewanella are affected by their surface polysaccharides
    Anton Korenevsky
    Department of Molecular and Cellular Biology and Advanced Foods and Materials Network Networks of Centres of Excellence, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Microbiology 153:1872-83. 2007
    ..These findings remained true for Shewanella strains grown under either aerobic or anaerobic conditions, although the surfaces of anaerobic cells appeared to be less electronegative and more hydrophilic than those of aerobic cells...
  8. ncbi An in vitro comparison of the intraradicular dentin bond strength of Resilon and gutta-percha
    Lance J Skidmore
    Department of Endodontics, Marquette University, School of Dentistry, Milwaukee, Wisconsin 53233, USA
    J Endod 32:963-6. 2006
    ..The results show that the mean bond strength to root canal dentin was significantly higher (p < 0.05) in the Resilon/Epiphany group as compared to the gutta-percha/Kerr Pulp Canal Sealer EWT group...
  9. pmc Evidence for self-cleaning in gecko setae
    W R Hansen
    Department of Physics and Biology, Lewis and Clark College, Portland, OR 97219, USA
    Proc Natl Acad Sci U S A 102:385-9. 2005
    ..We propose that the property of self-cleaning is intrinsic to the setal nanostructure and therefore should be replicable in synthetic adhesive materials in the future...
  10. pmc AtaA, a new member of the trimeric autotransporter adhesins from Acinetobacter sp. Tol 5 mediating high adhesiveness to various abiotic surfaces
    Masahito Ishikawa
    Department of Biotechnology, Graduate School of Engineering, Nagoya University, Furo cho, Chikusa ku, Japan
    PLoS ONE 7:e48830. 2012
    Acinetobacter sp. Tol 5 exhibits an autoagglutinating nature and noteworthy adhesiveness to various abiotic surfaces from hydrophobic plastics to hydrophilic glass and stainless steel...
  11. ncbi Thermosensitive and mucoadhesive in situ gel based on poloxamer as new carrier for rectal administration of nimesulide
    Yuan Yuan
    Department of Pharmacy, Logistic University of Chinese People s Armed Police Forces, China
    Int J Pharm 430:114-9. 2012
    ..In addition, it resulted in significantly higher initial serum concentrations, C(max) and AUC of NM compared to the solid suppository...
  12. ncbi Thermoreversible mucoadhesive ophthalmic in situ hydrogel: Design and optimization using a combination of polymers
    Divyesh H Shastri
    Department of Pharmaceutics, K B Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat 382023, India
    Acta Pharm 60:349-60. 2010
    ..The quadratic mathematical model developed is applicable to predicting formulations with desired gelation temperature, gel strength, bioadhesion force and drug release properties...
  13. pmc Evidence for van der Waals adhesion in gecko setae
    Kellar Autumn
    Department of Biology, Lewis and Clark College, Portland, OR 97219, USA
    Proc Natl Acad Sci U S A 99:12252-6. 2002
    ..Both artificial setal tips stuck as predicted and provide a path to manufacturing the first dry, adhesive microstructures...
  14. ncbi Effect of different irrigation protocols on resin sealer bond strength to dentin
    Maíra Prado
    Department of Restorative Dentistry, Endodontics Division, State University of Campinas, Piracicaba, Sao Paulo, Brazil
    J Endod 39:689-92. 2013
    ..The aim of this study was to evaluate the influence of different irrigation protocols on resin-based sealer bond strength to dentin and the associated failure pattern...
  15. ncbi A reversible wet/dry adhesive inspired by mussels and geckos
    Haeshin Lee
    Biomedical Engineering Department, Northwestern University, Evanston, Illinois 60208, USA
    Nature 448:338-41. 2007
    ..This hybrid adhesive, which combines the salient design elements of both gecko and mussel adhesives, should be useful for reversible attachment to a variety of surfaces in any environment...
  16. ncbi Analysis of resin tags formation in root canal dentine: a cross sectional study
    Y Malyk
    Department of Restorative Dentistry and Periodontology, Ludwig Maximilians University, Munich, Germany
    Int Endod J 43:47-56. 2010
    ..To evaluate the length, density and quality of resin tags formed by penetration of various types of adhesive systems into dentinal tubules at various cross section levels of the root canal in correlation to the density of dentinal tubules...
  17. ncbi Carbon nanotube arrays with strong shear binding-on and easy normal lifting-off
    Liangti Qu
    Department of Chemical and Materials Engineering, School of Engineering, University of Dayton, 300 College Park, Dayton, OH 45469, USA
    Science 322:238-42. 2008
    ..The mimetic adhesives can be alternatively binding-on and lifting-off over various substrates for simulating the walking of a living gecko...
  18. ncbi Effect of stiffness of multi-level hierarchical attachment system on adhesion enhancement
    Tae Wan Kim
    Nanotribology Laboratory for Information Storage and MEMS NEMS, The Ohio State University, 201 W 19th Avenue, Columbus, OH 43210 1142, USA
    Ultramicroscopy 107:902-12. 2007
    ..The efficiency of attachment-the adhesion coefficient, the adhesion force, the number of contacts and the adhesion energy-for the three-level models with different stiffness is investigated in contact with different rough surfaces...
  19. pmc Adhesion and friction in gecko toe attachment and detachment
    Yu Tian
    Department of Chemical Engineering and California NanoSystems Institute CNSI, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 103:19320-5. 2006
    ..The results have obvious implications for the fabrication of dry adhesives and robotic systems inspired by the gecko's locomotion mechanism...
  20. ncbi Changes in materials properties explain the effects of humidity on gecko adhesion
    Jonathan B Puthoff
    Department of Biology, Lewis and Clark College, Portland, OR 97219 7899, USA
    J Exp Biol 213:3699-704. 2010
    ..Changes in setal materials properties, not capillary forces, fully explain humidity-enhanced adhesion, and van der Waals forces remain the only empirically supported mechanism of adhesion in geckos...
  21. pmc The influence of nano MgO and BaSO4 particle size additives on properties of PMMA bone cement
    Alyssa Ricker
    Divisions of Engineering and Orthopaedics, 184 Hope Street, Brown University, Providence, RI 02912, USA
    Int J Nanomedicine 3:125-32. 2008
    ..This study, thus, suggests that nanoparticles of MgO and BaSO4 should be further studied for improving properties of PMMA for orthopedic applications...
  22. ncbi Bond strength of composite to dentin using conventional, one-step, and self-etching adhesive systems
    S Bouillaguet
    Department of Cariology, Endodontics and Pediatric Dentistry, School of Dental Medicine, University of Geneva, 19 Rue Barthélemy Menn 1205, Geneva, Switzerland
    J Dent 29:55-61. 2001
    ..This in vitro study compared the dentin bonding performance of eight adhesive systems using a microtensile bond strength test...
  23. pmc New insights into the properties of pubescent surfaces: peach fruit as a model
    Victoria Fernandez
    Genetics and Eco physiology Research Group, School of Forest Engineering, Technical University, 28040 Madrid, Spain
    Plant Physiol 156:2098-108. 2011
    ..The significance of the data concerning water-plant surface interactions is discussed within a physiological context...
  24. pmc Ultrastructure and physical properties of an adhesive surface, the toe pad epithelium of the tree frog, Litoria caerulea White
    Ingo Scholz
    Department of Cellular Neurobionics, Institute of Biology 2, RWTH Aachen, Kopernikusstrasse 16, 52056 Aachen, Germany
    J Exp Biol 212:155-62. 2009
    ..The biomimetic implications of these findings are reviewed...
  25. pmc Evidence for capillarity contributions to gecko adhesion from single spatula nanomechanical measurements
    Gerrit Huber
    Max Planck Institute for Metals Research, Heisenbergstrasse 3, D 70569 Stuttgart, Germany
    Proc Natl Acad Sci U S A 102:16293-6. 2005
    ..Acad. Sci. USA 99, 12252-12256], our measurements clearly show that humidity contributes significantly to gecko adhesion on a nanoscopic level. These findings are crucial for the development of artificial biomimetic attachment systems...
  26. ncbi Systematic review of the chemical composition of contemporary dental adhesives
    Kirsten L Van Landuyt
    Leuven BIOMAT Research Cluster, Department of Conservative Dentistry, School of Dentistry, Oral Pathology and Maxillo Facial Surgery, Catholic University of Leuven, Kapucijnenvoer 7, B 3000 Leuven, Belgium
    Biomaterials 28:3757-85. 2007
    ..This paper includes an extensive table with the chemical formulation of contemporary dental adhesives...
  27. ncbi Influence of surface roughness on gecko adhesion
    Gerrit Huber
    Max Planck Institute for Metals Research, Heisenbergstrasse 3, 70569 Stuttgart, Germany
    Acta Biomater 3:607-10. 2007
    ..Both experiments consistently show that the effective adhesion shows a minimum for a root mean square roughness ranging from 100 to 300nm...
  28. ncbi Push-out strength of root fillings with or without thermomechanical compaction
    S M B S Carneiro
    School of Dentistry, University of Ribeirao Preto, Ribeirao Preto, SP, Brasil
    Int Endod J 45:821-8. 2012
    ..To evaluate the influence of thermomechanical compaction (Tagger's hybrid technique - THT) on the push-out strength of several root filling materials to root dentine...
  29. ncbi Evaluation of push-out bond strength of two endodontic post systems
    Konstantinos Mastoras
    Department of Endodontics, Division of Pathology and Therapeutics of Dental Tissues and Basic Dental Sciences, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Endod 38:510-4. 2012
    ..The aim of this study was to evaluate the push-out bond strengths of a new polyfiber post system and a fiber post that were adhesively luted with a dual-cure resin cement...
  30. ncbi Evaluation of adhesiveness of Acinetobacter sp. Tol 5 to abiotic surfaces
    Masahito Ishikawa
    Department of Biotechnology, Graduate School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    J Biosci Bioeng 113:719-25. 2012
    ..In the present study, various aspects of the adhesiveness of Tol 5 cells were evaluated, namely, the association with biofilm formation, the specificity, and the effects ..
  31. ncbi Interspecific comparison of the mechanical properties of mussel byssus
    Shanna L Brazee
    Department of Biological Sciences, University of Rhode Island, Kingston, Rhode Island 02881, USA
    Biol Bull 211:263-74. 2006
    ..This comparative study not only provides insight into the ecological limitations and evolution of mussels, but also suggests new models for the design of novel biomimetic polymers...
  32. ncbi Inhibition of membrane-bound carbonic anhydrase enhances subretinal fluid absorption and retinal adhesiveness
    T J Wolfensberger
    Department of Ophthalmology, Stanford University School of Medicine, Stanford, USA
    Graefes Arch Clin Exp Ophthalmol 238:76-80. 2000
    ..This study investigates how benzolamide, a carbonic anhydrase inhibitor which does not readily penetrate cell membranes, modulates retinal pigment epithelium functions relative to acetazolamide, which diffuses into the cytosol...
  33. ncbi A novel OCT technique to measure in vivo the corneal adhesiveness for sodium carboxymethylcellulose in humans and its validity in the diagnosis of dry eye
    Pietro Emanuele Napoli
    Department of Surgical Sciences, Eye Clinic, University of Cagliari, Cagliari, Italy
    Invest Ophthalmol Vis Sci 55:3179-85. 2014
  34. pmc Configuration of the setal fields of Rhoptropus (Gekkota: Gekkonidae): functional, evolutionary, ecological and phylogenetic implications of observed pattern
    Megan K Johnson
    University of Calgary, Department of Biological Sciences, Canada
    J Anat 214:937-55. 2009
    ..Our findings have implications for the understanding of the evolution of adhesive structures, and for the principles used for generating and manufacturing biomimetic artificial microfibrillar arrays...
  35. pmc Adhesion and merging of lipid bilayers: a method for measuring the free energy of adhesion and hemifusion
    Yen Sun
    Department of Physics and Astronomy, Rice University, Houston, Texas, USA
    Biophys J 100:987-95. 2011
    ..This is relevant for current research on membrane fusion, which focuses on how fusion proteins induce lipid transformations...
  36. ncbi Subdigital setae of narrow-toed geckos, including a Eublepharid (Aeluroscalabotes felinus)
    Anne M Peattie
    University of California, Berkeley, Department of Integrative Biology, Berkeley, California, USA
    Anat Rec (Hoboken) 291:869-75. 2008
  37. ncbi Thiomers: preparation and in vitro evaluation of a mucoadhesive nanoparticulate drug delivery system
    Andreas Bernkop-Schnürch
    Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold Franzens University Innsbruck, Innrain 52, Josef Moller Haus, 6020 Innsbruck, Austria
    Int J Pharm 317:76-81. 2006
    ..Therefore, they seem to be advantageous over ionically crosslinked chitosan nanoparticles...
  38. ncbi Comparison of neuronal cell adhesiveness of materials in the diX (Parylene) family
    Yasuhiro X Kato
    NTT Communication Science Laboratories, Nippon Telegraph and Telephone Corporation, 243 0198 Kanagawa, Japan
    Neurosci Lett 464:26-8. 2009
    ..However, its uses are limited due to its extremely low adhesiveness with neuronal cells...
  39. ncbi Effect of thermal cycling on enamel bond strength of single-step self-etch systems
    Shino Amano
    Nihon University, School of Dentistry, Department of Operative Dentistry, Tokyo, Japan
    Oper Dent 31:616-22. 2006
    ..With a careful choice of adhesive systems, the benefit to using single-step self-etch systems in terms of simplifying the clinical procedure might be acceptable, even after thermal stresses...
  40. ncbi Effective elastic modulus of isolated gecko setal arrays
    K Autumn
    Department of Biology, Lewis and Clark College, Portland, OR 97219, USA
    J Exp Biol 209:3558-68. 2006
    ..Unlike synthetic PSAs, setal arrays act as Hookean elastic solids; setal arrays function as a bed of springs with a directional stiffness, assisting alignment of the adhesive spatular tips with the contact surface during shear loading...
  41. ncbi Nanostructure-dependent water-droplet adhesiveness change in superhydrophobic anodic aluminum oxide surfaces: from highly adhesive to self-cleanable
    Wonbae Lee
    Department of Biomedical Engineering, College of Health Science, Korea University San 1, Jeongneung 3 dong, Seongbuk gu, Seoul 136 703, Korea
    Langmuir 26:1412-5. 2010
    Water-droplet adhesiveness was freely controlled on a single platform of superhydrophobic anodized aluminum oxide (AAO) within the range from highly adhesive to self-cleanable...
  42. ncbi Shear induced adhesion: contact mechanics of biological spatula-like attachment devices
    Alexander Filippov
    Donetsk Institute for Physics and Engineering, National Academy of Science, Ukraine
    J Theor Biol 276:126-31. 2011
    ..At such equilibrium, maximal adhesion can be generated. This principle manifests the crucial role of spatulate terminal elements in biological fibrillar adhesion...
  43. ncbi Adhesiveness and purulence of respiratory secretions: implications for mucociliary transport in patients with bronchiectasis
    Joana Tambascio
    Lucy Montoro Rehabilitation Institute, University of São Paulo at Ribeirão Preto School of Medicine, Ribeirao Preto, Brazil
    J Bras Pneumol 36:545-53. 2010
    ..To analyze and compare the transport properties of respiratory secretions, classified by selected parameters, in individuals with bronchiectasis unrelated to cystic fibrosis...
  44. ncbi Adhesion and friction force coupling of gecko setal arrays: implications for structured adhesive surfaces
    Boxin Zhao
    Department of Chemical Engineering and Materials Research Laboratory, University of California at Santa Barbara, Santa Barbara, CA 93106, USA
    Langmuir 24:1517-24. 2008
    ..Our results also have practical implications and criteria for designing reversible and responsive adhesives and articulated robotic mechanisms...
  45. ncbi Increase in cell adhesiveness on a poly(ethylene terephthalate) fabric by sintered hydroxyapatite nanocrystal coating in the development of an artificial blood vessel
    Tsutomu Furuzono
    Department of Bioengineering, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Osaka, Japan
    ASAIO J 52:315-20. 2006
    ..A prototype of an artificial blood vessel was finally fabricated by use of HAp/PET composite...
  46. ncbi Bonding of stainless steel brackets to enamel with a new self-etching primer
    Ryan W Arnold
    Department of Oral Sciences, School of Dentistry, University of Minnesota, 515 Delaware Street SE, Minneapolis, MN 55455, USA
    Am J Orthod Dentofacial Orthop 122:274-6. 2002
    ..05). Under the conditions of these experiments, a 10-minute delay in bonding after application of the self-etching primer might not be deleterious to adhesion...
  47. ncbi Liposome coated with low molecular weight chitosan and its potential use in ocular drug delivery
    Ning Li
    School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China
    Int J Pharm 379:131-8. 2009
    ..In conclusion, the LCH coating significantly modified the properties of liposome and brought a series of notable advantages for ocular drug delivery...
  48. ncbi Rheological characterisation of primary and binary interactive bioadhesive gels composed of cellulose derivatives designed as ophthalmic viscosurgical devices
    Gavin P Andrews
    Medical Polymers Research Institute, The Queen s University of Belfast, Medical Biology Centre, 97, Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK
    Biomaterials 26:571-80. 2005
    ..Based on the described rheological properties it is suggested that binary gels composed of mass ratios of HEC to NaCMC of either 3.6: 2.4 or 2.4: 3.6 would be acceptable as OVD and would uniquely offer duality of function...
  49. ncbi Shear bond strength of self-etch adhesives to enamel with additional phosphoric acid etching
    Anne Katrin Lührs
    Department of Conservative Dentistry, Periodontology and Preventive Dentistry, Hannover Medical School, Hannover, Germany
    Oper Dent 33:155-62. 2008
    ..An additional phosphoric acid etching of enamel should be considered when using self-etch adhesives. More clinical studies are needed to evaluate the long-term success of the examined adhesives...
  50. ncbi Synthesis and characterisation of mucoadhesive thiolated polymers
    A Bernkop-Schnürch
    Institute of Pharmaceutical Technology, Center of Pharmacy, University of Vienna, Althanstrasse 14, A 1090, Vienna, Austria
    Int J Pharm 194:239-47. 2000
    ..The results represent helpful basic information in order to improve the mucoadhesive properties of thiolated polymers...
  51. ncbi Effectiveness of submicron-sized, chitosan-coated liposomes in oral administration of peptide drugs
    Hirofumi Takeuchi
    Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Int J Pharm 303:160-70. 2005
    ..The chitosan-coated ssLip, with their higher retentive property in the intestinal tract, are much more effective than ssLip and CS-Lip in improving the enteral absorption of peptide drugs...
  52. ncbi Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems
    Hirofumi Takeuchi
    Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, Japan 5 6 1 Mitahora Higashi Gifu, 502 8585, Japan
    Adv Drug Deliv Rev 57:1583-94. 2005
    ..These observations explained well the superiority of the ssCS-Lip as drug carrier in oral administration of calcitonin in rats than other liposomal particles...
  53. ncbi Thiolated polymers--thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates
    C E Kast
    Institute of Pharmaceutical Technology and Biopharmaceutics, Center of Pharmacy, University of Vienna, Austria
    Biomaterials 22:2345-52. 2001
    ..According to these results. chitosan-TGA conjugates represent a promising tool for the development of mucoadhesive drug delivery systems...
  54. pmc Understanding marine mussel adhesion
    Heather G Silverman
    Biological Systems Department, Idaho National Laboratory, Idaho Falls, Idaho 83415, USA
    Mar Biotechnol (NY) 9:661-81. 2007
    ..This study provides a background on adhesive proteins identified in the blue mussel, Mytilus edulis, and introduces our research interests and discusses the future for continued research related to mussel adhesion...
  55. pmc A beetle-inspired solution for underwater adhesion
    M Varenberg
    Department of Thin Films and Biological Systems, Max Planck Institute for Metals Research, Heisenbergstrasse 3, Stuttgart 70569, Germany
    J R Soc Interface 5:383-5. 2008
    ..This results in a higher adhesive capability of the material, with potential in medicine, bio- and marine technologies and a range of applications in liquid-dominated environments...
  56. pmc Overexpression of the Candida albicans ALA1 gene in Saccharomyces cerevisiae results in aggregation following attachment of yeast cells to extracellular matrix proteins, adherence properties similar to those of Candida albicans
    N K Gaur
    Department of Research, Veterans Affairs Medical Center, Kansas City, Missouri 64128, USA
    Infect Immun 67:6040-7. 1999
    ..The similarities in the adherence and aggregation properties of C. albicans and S. cerevisiae overexpressing ALA1 suggest a role in adherence and aggregation for ALA1 and ALA1-like genes in C. albicans...
  57. ncbi The role of granules within viscous capture threads of orb-weaving spiders
    B D Opell
    Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    J Exp Biol 213:339-46. 2010
  58. ncbi Formulation and evaluation of oral mucoadhesive multiparticulate system containing metoprolol tartarate: an in vitro-ex vivo characterization
    Veena Belgamwar
    R C Patel College of Pharmacy, Shirpur, State, Maharashtra, India
    Curr Drug Deliv 6:113-21. 2009
    ..57 to 0.73. The stability studies performed on the optimized batches at 40 degrees C /75% RH for 90 days indicated no significant change in the physicochemical properties...
  59. ncbi Adhesion of echinoderm tube feet to rough surfaces
    Romana Santos
    Académie Universitaire Wallonie Bruxelles, Universite de Mons Hainaut, Laboratoire de Biologie Marine, 6 Avenue du Champ de Mars, B 7000 Mons, Belgium
    J Exp Biol 208:2555-67. 2005
    ..Under short pulses of wave-generated forces, attached discs probably behave elastically, distributing the stress along the entire contact area, in order to avoid crack generation and thus precluding disc peeling and tube foot detachment...
  60. ncbi Cross-linking the protein precursor of marine mussel adhesives: bulk measurements and reagents for curing
    Jennifer Monahan
    Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA
    Langmuir 20:3724-9. 2004
    ..The results show that optimal curing occurs when the reagent is an oxidizing metal ion (e.g., MnO4-, Fe3+). We conclude that marine mussels are likely to employ Mn3+ and Fe3+ for protein cross-linking and adhesive synthesis...
  61. ncbi A microshear test to measure bond strengths of dentin-polymer interfaces
    Walter G McDonough
    Polymers Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Biomaterials 23:3603-8. 2002
  62. pmc Single-molecule mechanics of mussel adhesion
    Haeshin Lee
    Department of Biomedical Engineering and Materials Science and Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 103:12999-3003. 2006
  63. ncbi Barnacle reattachment: a tool for studying barnacle adhesion
    D Rittschof
    Duke University Marine Laboratory, Beaufort, North Carolina, USA
    Biofouling 24:1-9. 2008
    ..The method enables down-selection of coatings from combinatorial approaches to manageable levels for definitive field testing. Reattachment can be used with coatings that combine antifouling and fouling-release technologies...
  64. ncbi Contact angle anomalies indicate that surface-active eluates from silicone coatings inhibit the adhesive mechanisms of fouling organisms
    Anne Meyer
    Industry University Center for Biosurfaces, University at Buffalo, Buffalo, New York 14214, USA
    Biofouling 22:411-23. 2006
    ..Swelling of the silicone elastomeric coatings by hydrocarbon fluids was observed for all four coatings, before and after immersion...
  65. ncbi Linking adhesive and structural proteins in the attachment plaque of Mytilus californianus
    Hua Zhao
    Department of Molecular, Cellular and Developmental Biology, Marine Science Institute, University of California, Santa Barbara, California 93106, USA
    J Biol Chem 281:26150-8. 2006
    ..5-S-Cysteinyldopa was detected at nearly 1 mol %. The results suggest that mcfp-6 may provide a cohesive link between the surface-coupling Dopa-rich proteins and the bulk of the plaque proteins...
  66. ncbi Erythrocyte adhesiveness/aggregation: a novel biomarker for the detection of low-grade internal inflammation in individuals with atherothrombotic risk factors and proven vascular disease
    Shlomo Berliner
    Department of Internal Medicine D, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Am Heart J 149:260-7. 2005
  67. pmc Thermal gelation and tissue adhesion of biomimetic hydrogels
    Sean A Burke
    Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA
    Biomed Mater 2:203-10. 2007
    ..1 kPa, SD = 12.5 kPa, n = 11) was several times stronger than a fibrin glue control tested under the same conditions. The results suggest a possible use of this biomimetic strategy for repair of soft tissues...
  68. ncbi Viscoelastic solids explain spider web stickiness
    Vasav Sahni
    Department of Polymer Science, Integrated Bioscience Program, The University of Akron, Akron, OH 44325 3909, USA
    Nat Commun 1:19. 2010
    ..The glycoproteins in the glue droplets behave as a viscoelastic solid and the elasticity is critical in enhancing adhesion caused by specific adhesive ligands. These results have important implications in mimicking bioadhesives...
  69. pmc Strong reversible Fe3+-mediated bridging between dopa-containing protein films in water
    Hongbo Zeng
    Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, T6G 2V4 Canada
    Proc Natl Acad Sci U S A 107:12850-3. 2010
    ..The results suggest that dopa-metal interactions may provide an energetic new paradigm for engineering strong, self-healing interactions between polymers under water...
  70. ncbi The correlation between the adsorption of adhesive proteins and cell behaviour on hydroxyl-methyl mixed self-assembled monolayers
    Cristina C Barrias
    INEB Instituto de Engenharia Biomedica, Divisão de Biomateriais, Universidade do Porto, R Campo Alegre 823, 4150 180 Porto, Portugal
    Biomaterials 30:307-16. 2009
  71. ncbi Tensile bond strength of different adhesive systems between bone and composite compared: an in vitro study
    Peter Maurer
    Department of Oral and Plastic Maxillofacial Surgery, Martin Luther University, Halle Wittenberg, Germany
    J Craniomaxillofac Surg 32:85-9. 2004
    ..The aim was to compare tensile bond strength of three dentine adhesive systems (Excite, Clearfil New Bond, Etch & Prime 3.0) and two cyanoacrylate adhesives (Cyano Veneer, Histoacryl) to animal bone in vitro...
  72. pmc Adhesion mechanisms of the mussel foot proteins mfp-1 and mfp-3
    Qi Lin
    Department of Chemical Engineering, Graduate Program in Biomolecular Science and Engineering, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 104:3782-6. 2007
    ..g., their inability to be peeled off) rather than a high intrinsic surface or adhesion energy, W...
  73. ncbi [Application of an amphiphilic bonder in a goat model to increase the femoral cement-bone adhesion in cemented hip arthroplasty]
    R Muller-Rath
    Orthopadische Klinik, RWTH Aachen
    Z Orthop Unfall 145:476-82. 2007
    ..The aim of this study is to evaluate the biocompatibility of such a bonder and its effects on the mechanical stability of cemented hip arthroplasty stems in vivo...
  74. ncbi Characterisation of bioadhesives for periodontal and oral mucosal drug delivery
    I G Needleman
    Department of Periodontology, Eastman Dental Institute, London, UK
    J Clin Periodontol 25:74-82. 1998
    ..Physical characterisation therefore appears to have an important place in screening polymeric formulations prior to clinical testing in the periodontal pocket and oral mucosa...
  75. ncbi Properties of a new injectable type of root canal filling resin with adhesiveness to dentin
    Yohji Imai
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan
    J Endod 29:20-3. 2003
    ..type of root canal wall, adhesive filling resin, which we developed, were studied for its physical properties, adhesiveness to dentin and the root canal, and sealing ability...
  76. ncbi Integrative cartilage repair: adhesive strength is correlated with collagen deposition
    M A DiMicco
    Department of Bioengineering and Institute for Biomedical Engineering, University of California, San Diego, La Jolla 92093-0412, USA
    J Orthop Res 19:1105-12. 2001
  77. ncbi Environmental bioadhesion: themes and applications
    L O Burzio
    Instituto de Bioquimica, Facultad de Ciencias, Universidad Austral de Chile, Valdivia
    Curr Opin Biotechnol 8:309-12. 1997
    ..The use of these adhesive proteins as anticorrosive coats for metal also suggests important applications for industry...
  78. ncbi A glycosylated byssal precursor protein from the green mussel Perna viridis with modified dopa side-chains
    Kousaku Ohkawa
    Institute of High Polymer Research, Faculty of Textile Science and Technology Shinshu University Tokida 3 15 1 Ueda 386 8567 Japan
    Biofouling 20:101-15. 2004
    ..The sequence homology of Pvfp-1 with the common structural motifs of the fp-1 protein family strongly suggests that the Pvfp-1 functions as the byssal coating (lacquer) protein...
  79. ncbi A molecular, morphometric and mechanical comparison of the structural elements of byssus from Mytilus edulis and Mytilus galloprovincialis
    Jared M Lucas
    Marine Science Institute and Molecular, Cellular and Developmental, Biology Department, University of California at Santa Barbara, Santa Barbara, CA 93106, USA
    J Exp Biol 205:1807-17. 2002
    ..It is apparent from this comparison that M. galloprovincialis and M. edulis are seemingly interchangeable models for byssal research...
  80. ncbi A new long acting ophthalmic formulation of carteolol containing alginic acid
    O Sechoy
    Centre de Recherche, Laboratorie CHAUVIN, Le Millénaire B P 1174 34009 Cedex 1, Montpellier, France
    Int J Pharm 207:109-16. 2000
    ..The overall results of this study indicate that the alginic-acid vehicle is an excellent drug carrier, well tolerated, and could be used for the development of a long-acting ophthalmic formulation of carteolol...
  81. ncbi van der Waals and hygroscopic forces of adhesion generated by spider capture threads
    Anya C Hawthorn
    College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA
    J Exp Biol 206:3905-11. 2003
    ..The appearance of fibril nodes introduced hydrophilic sites that implemented hygroscopic force and increased thread stickiness under intermediate and high humidity...
  82. ncbi Soybean glycinin subunits: Characterization of physicochemical and adhesion properties
    Xiaoqun Mo
    Bio Material and Technology Lab, BIVAP, Department of Grain Science and Industry, Kansas State University, Manhattan, Kansas 66506, USA
    J Agric Food Chem 54:7589-93. 2006
    ..Basic subunits are responsible for the water resistance of glycinin and are a good starting material for the development of water-resistant adhesives...
  83. ncbi Mussel byssus and biomolecular materials
    T J Deming
    Departments of Materials and Chemistry, University of California, SantaBarbara, CA 93106, USA
    Curr Opin Chem Biol 3:100-5. 1999
    ..These discoveries have led to the development of recombinant proteins and synthetic polypeptides that are able to reproduce the properties of mussel adhesives for applications in medicine and biotechnology...
  84. ncbi Integrative biology of sticky feet in geckos
    Eric R Pianka
    Integrative Biology C0930, University of Texas, Austin, TX 78712 1064, USA
    Bioessays 27:647-52. 2005
    ..Emergent properties arising from molecular adhesion include several adaptive radiations that have produced a great diversity of geckos worldwide...
  85. ncbi Comparative in vitro study of oesophageal adhesiveness of different commercial formulations containing alendronate
    Monjed Shakweh
    Laboratoire de Physicochimie, Pharmacotechnie et Biopharmacie, UMR CNRS 8612, Universite Paris Sud, Chatenay Malabry, France
    Eur J Pharm Sci 31:262-70. 2007
    ..The demonstrated differences in adhesiveness suggest that differences in oesophageal tolerance between Fosamax tablets and generics of sodium alendronate ..
  86. ncbi Resistance to degradation of resin-dentin bonds using a one-step HEMA-free adhesive
    Francesca Monticelli
    Department of Dental Materials, School of Dentistry, University of Granada, Spain
    J Dent 35:181-6. 2007
    ..To evaluate the resistance to degradation of resin-dentin bonds formed with a one-step acetone-containing and HEMA-free adhesive...
  87. ncbi Step-cure polymerization: effect of initial light intensity on resin/dentin bond strength in class I cavities
    Alex Jose Souza Santos
    Potiguar School of Dentistry, Potiguar University UnP, RN, Brazil
    Oper Dent 31:324-31. 2006
    ..05). The use of a low initial light intensity (200-250 mW/cm2) for 10 seconds followed by high irradiation intensity provided the best bond strengths, similar to bonding in a flat cavity...
  88. ncbi Fractured surface characterization: wet versus dry bonding
    M Hashimoto
    Department of Pediatric Dentistry, School of Dentistry, Hokkaido University, North 13, West 17, Kita ku, Sapporo 060 8586, Hokkaido, Japan
    Dent Mater 18:95-102. 2002
    ..Fractographic analysis was conducted to evaluate the resin-dentin bond structures made under wet and dry conditions...
  89. ncbi Effects of cleaning agents on bond strength to dentin
    Celso Rosin
    Department of Restorative Dentistry, School of Dentistry, University of Sao Paulo
    Braz Oral Res 19:127-33. 2005
    ..Based on statistical and SEM analysis, it was concluded that the cleaning agents studied did not interfere with the bond strength of the adhesive systems used to dentin...
  90. ncbi Microtensile bond strength tests: scanning electron microscopy evaluation of sample integrity before testing
    Marco Ferrari
    Department of Dental Materials, University of Sienna, Sienna, Italy
    Eur J Oral Sci 110:385-91. 2002
    ..It seems sensible to develop a method for a quantitative assessment of specimens integrity before loading as a possible predictor for their performance under load...
  91. ncbi Bond durability of the resin-bonded and silane treated ceramic surface
    Tabassom Hooshmand
    Department of Restorative Dentistry, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield S10 2TA, UK
    Dent Mater 18:179-88. 2002
  92. ncbi The effects of luting resin bond to dentin on the strength of dentin supported by indirect resin composite
    Koji Furukawa
    Cariology and Operative Dentistry, Department of Restorative Sciences, Graduate School, Tokyo Medical and Dental University, 5 45 Yushima 1 chome, Bunkyo ku, Tokyo 113 8549, Japan
    Dent Mater 18:136-42. 2002
    ..The purpose of this study was to evaluate the effects of thickness and adhesion of three resin cements on the fracture resistance of indirect resin composite bonded to dentin...
  93. ncbi Effect of different bur grinding on the bond strength of self-etching adhesives
    Stefano Semeraro
    Department of Prosthodontics, School of Dentistry, University of Milan, Milan, Italy
    Oper Dent 31:317-23. 2006
    ..In conclusion, when cutting dentin, selecting the proper bur type is important for improving the bond strength of some self-etching adhesive systems...
  94. ncbi Effect of dentinal surface preparation on bond strength of self-etching adhesives
    Cynthia K Y Yiu
    Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong SAR, China
    J Adhes Dent 10:173-82. 2008
    ..This study examined the effects of cutting dentin with different burs at various speeds on the microtensile bond strength (muTBS) of two self-etching adhesive systems...
  95. ncbi The microtensile bond strength of self-etching adhesives to ground enamel
    William W Brackett
    Department of Oral Rehabilitation, School of Dentistry, Medical College of Georgia, Augusta, GA, USA
    Oper Dent 31:332-7. 2006
  96. ncbi Comparison of bond strengths using different curing lights
    Scott M Peterson
    Department of Orthodontics, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Clin Orthod 40:309-13; quiz 307. 2006
  97. ncbi Four-year water degradation of a total-etch and two self-etching adhesives bonded to dentin
    Ali I Abdalla
    Department of Restorative Dentistry, Faculty of Dentistry, University of Tanta, Tanta, Egypt
    J Dent 36:611-7. 2008
    ..To evaluate effect of direct and indirect water storage on the microtensile dentin bond strength of one total-etch and two self-etching adhesives...
  98. ncbi Influence of additional adhesive application on the microtensile bond strength of adhesive systems
    André Luís Faria de Silva
    Department of Restorative Dentistry, Piracicaba School of Dentistry, University of Campinas, Piracicaba, Sao Paulo, Brazil
    Oper Dent 31:562-8. 2006
    ..G6 and G7 presented the lowest microTBS values. When solvent-free adhesives systems were used, microTBS values were not affected by the thicker layer...
  99. ncbi Influence of airborne-particle abrasion on mechanical properties and bond strength of carbon/epoxy and glass/bis-GMA fiber-reinforced resin posts
    Carlos Jose Soares
    Biomechanical Group, Dentistry and Dental Materials School of Dentistry, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil
    J Prosthet Dent 99:444-54. 2008
    ..Controversy exists concerning the use of fiber-reinforced posts to improve bond strength to resin cement because some precementation treatments can compromise the mechanical properties of the posts...
  100. ncbi Dentin bonding on different walls of a class II preparation
    Andrea Nobrega Cavalcanti
    Department of Restorative Dentistry, Piracicaba Dental School, UNICAMP, Av Limeira 901, 13 414 900, Piracicaba, SP, Brazil
    J Adhes Dent 10:17-23. 2008
    ..To evaluate the bond strength on different cavity walls of Class II preparations. Different bonding systems and the effect of thermomechanical cycling were investigated...
  101. ncbi Shear bond strength between nickel-chromium and human dentine using a dual-cure, self-adhesive universal resin luting agent
    John Chai
    Prince Philip Dental Hospital, Hong Kong
    Eur J Prosthodont Restor Dent 16:85-8. 2008
    ..Given the simplicity of use of the dual-cure, self-adhesive universal resin luting agent, it appears to be promising in clinical applications...

Research Grants62

  1. Synthesis and properties of a bacterial bioadhesive
    Yves V Brun; Fiscal Year: 2013
    ..The project has three specific aims. The first aim is to determine the biophysical basis for holdfast adhesiveness. Atomic force microscopy (AFM) will be used to systematically study the influence of surface roughness, shear ..
  2. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Martin Bluth; Fiscal Year: 2007
    ..once HAF is injected in the peritoneal cavity, it distributes and adheres evenly to the walls, improving the adhesiveness between lacerated tissues and potentiating clot formation through the up-regulation of P-selectin...
  3. The role of adenosine kinase in atherosclerosis
    Yuqing Huo; Fiscal Year: 2013
    ..In specific aim 1, we will investigate the effect of endothelial ADK deficiency on the decreased inflammatory adhesiveness of the arterial endothelium and the suppressed formation of atherosclerotic lesions...
  4. Proteolysis of ultralarge von Willebrand factor and metabolic syndrome-diabetes
    Jing Fei Dong; Fiscal Year: 2011
    ..We have recently found that the activity of ADAMTS-13, which cleaves ULVWF to reduce its adhesiveness, is decreased in patients with severe systemic inflammation...
  5. Serine/Threonine Phosphatases and Platelet Physiology
    K Vinod Vijayan; Fiscal Year: 2013
    ..CIN85 depletion reduced Src activation and [unreadable]IIb[unreadable]3 adhesiveness. Using platelets and aIIbb3 model cells, we will test if PP2Ac negatively regulates outside-in signaling via ..
  6. Role of Missing Metastasis Gene in tumor progression
    STEVEN ZHAN; Fiscal Year: 2013
    ..Furthermore, we observed that null MIM cells displayed significantly altered shapes, reduced adhesiveness to extracellular matrix and the formation of actin stress fibers...
  7. R-Ras signaling in vascular biology
    Lawrence E Goldfinger; Fiscal Year: 2013
    ..R-Ras in particular functions to regulate adhesiveness, motility, proliferation and differentiation of cells of the vessel wall, and to modulate these processes ..
  8. Syndecan-1 in Lung Repair
    Peter Chen; Fiscal Year: 2013
    ..By functionally coupling itself to the a2[unreadable]1 integrin, syndecan-1 tunes the cell adhesiveness to collagen thereby allowing efficient cell migration to occur...
  9. Integrated Multi-scale Adhesive Dynamics Modeling of T-lymphocyte Homing
    Daniel A Hammer; Fiscal Year: 2013
    ..We show preliminary results that SLP-76 defects lead to a decrease in adhesiveness, and DGK defects lead to an increase in adhesiveness...
  10. Gene Delivery in Retinal Diseases
    John M Nickerson; Fiscal Year: 2013
    ..They penetrate through interstitial spaces through avidity and adhesiveness. 2. They penetrate cell membranes efficiently through lipid-raft uptake. 3...
  11. Modeling and microsystems approach to glioma invasion
    Steven S Rosenfeld; Fiscal Year: 2013
    ..the model will be tested in vivo by quantifying cell migration in live mouse brain slices as a function of cell adhesiveness, micromechanical brain stiffness, and brain micro-architecture...
  12. Intra-Oral drug-eluting adhesive film
    Haesun Park; Fiscal Year: 2011
    ..A series of films will be developed and will be evaluated for their buccal adhesiveness. The most promising films proceed to the drug loading test...
  13. Regulation of podocyte function by hic-5
    PETER H MUNDEL; Fiscal Year: 2013
    ..the induction of hic-5 expression in podocytes contributes to the pathogenesis of proteinuria by increasing the adhesiveness of podocyte to the extracellular matrix (ECM)/glomerular basement membrane (GBM)...
  14. Spatiotemporal Coordination of Formin and Arp2/3 in Epithelial Cell Migration
    Kwonmoo Lee; Fiscal Year: 2013
    ..assembly is mechano-responsive, I will investigate how the mechanical environment of different stiffness and adhesiveness of substrates affects Arp2/3 activation...
  15. CRIM1-b-Catenin-Cadherin Interactions in Eye Development and Disease
    RICHARD A contact LANG; Fiscal Year: 2010
    ..For example, regulation of cadherin adhesiveness is critical for eye-specific diseases such as secondary cataract formation where there is an epithelial to ..
  16. Coronary Vascular Cell Development
    Takashi Mikawa; Fiscal Year: 2013
    ..the PE in the mesoderm;2) oriented PE villous extension by an AVJ-derived directional cue(s);and 3) increased adhesiveness of PE cells to myocytes at the AVJ...
    Michael Lawrence; Fiscal Year: 1999
    ..and transendothelial migration occurs only alter a signal is received by the neutrophil to activate CD 18 adhesiveness. How neutrophils are signaled to arrest once they have begun rolling on the vessel wall is unknown...
  18. Hedgehog-mediated regulation of cell adhesion
    Xiaoyan Zheng; Fiscal Year: 2013
    ..The current view is that the response to the Hh signal induces a change in the adhesiveness and that this difference leads to the segregation of A cells from P cell...
  19. Structure/function studies of lactoferrin as a protease
    Andrew Plaut; Fiscal Year: 2005
    ..adhesins that mediate bacterial attachment to host epithelial cells, and lactoferrin cleavage reduces bacterial adhesiveness, in vitro. In our proposed studies we will develop quantitative assays for lactoferrin enzyme activity...
    MICHAEL CHARNESS; Fiscal Year: 1999
    ..immunoglobulin-like (Ig) or fibronectin type III repeat homology domains (FN3) of L1 exhibit ethanol-sensitive adhesiveness when expressed in NIH/3T3 cells, and will then learn whether specific deletions in the L1 cDNA abolish ethanol'..
    MARC VISNER; Fiscal Year: 1991
    ..and monocytes will be monitored in animals in which either PMNL and monocytes have been depleted or the CD-18 adhesiveness molecule on PMNL and monocytes has been blocked with antibody...
    IRWIN SHERMAN; Fiscal Year: 2004
    ..It is known that increased adhesiveness of the PE is due to parasite-induced changes in the erythrocyte membrane protein, band 3, as well as the ..
    Douglas Lauffenburger; Fiscal Year: 2002
    ..also established that individual cell movement speed depends on integrin/ligand binding through cell/substratum adhesiveness, in accord with their model predictions...
    PHILIP CRADDOCK; Fiscal Year: 1980
    ..complement activation (and the concomitant generation of C5a des arg) leads to augmented granulocyte adhesiveness and auto-aggregation...
    C Dewey; Fiscal Year: 1990
    ..ii) functional surface properties, as characterized by tissue factor procoagulant activity and surface adhesiveness for platelets; and (iii) receptor-mediated endocytosis, using the radiolabeled ligands alpha2-macroglobulin and ..
    Bruce Bochner; Fiscal Year: 1993
    ..Studies are designed to establish which inflammatory agents act on endothelial cells to induce adhesiveness for basophils, and which agents promote basophil adhesiveness by an effect primarily on the basophil...
    Alan Cross; Fiscal Year: 2002
    ..occurs during both myeloid maturation and activation and is accompanied by enhanced motility, deformability and adhesiveness. Sialidases are enzymes that rapidly remove sialic acid residues from glycoconjugates and on neutrophil ..
    Toshio Asakura; Fiscal Year: 2004 the left, induction of Hb F synthesis, hydration or reduction of dehydration of red blood cells (RBCs), and adhesiveness of RBCs to endothelial cells, are examined...
    Donald Miller; Fiscal Year: 2001
    ..A major cellular target for TNF-a is the endothelium, where increases in coagulant activity, cell adhesiveness and vascular permeability are observed...
    Robert Sah; Fiscal Year: 2004
    ..metabolically active cells at a cartilage-cartilage interface, and (3) developed a system to characterize adhesiveness of chondrocytes to articular cartilage (e.g., the surrounding host tissue)...
  31. Eptifibatide as Treatment for Acute Pain Episodes in Sickle Cell Disease
    Kenneth Ataga; Fiscal Year: 2009
    ..potent inflammatory mediator, CD40 ligand (CD40L), is known to increase leukocyte proliferation, endothelial adhesiveness and procoagulant activity, once it is exposed on the platelet surface and released into plasma following ..
    GEORGE LEIKAUF; Fiscal Year: 2001
    ..These proteins provide the characteristic viscosity, adhesiveness, and elasticity to the mucus lining the airways...
    Douglas Lauffenburger; Fiscal Year: 2000
    ..of these materials can be increased by progressively greater cross-linking via cysteine thiol groups; (b) cell adhesiveness to these materials is affected by the charge distribution on the peptides...
  34. Polysaccharide Hydrogel Fillers for Arteriovenous Malformation
    Weiliam Chen; Fiscal Year: 2007
    ..traditional agents because of: (i) minimal preparation time, (ii) rapid gelation within the vasculature, (iii) adhesiveness and cohesiveness to tissues that allow for vascular occlusion but minimize the risk for clogging catheters, and ..
  35. Cytoplasmic Regulation of a4b1 Avidity under Flow
    Mark Ginsberg; Fiscal Year: 2005
    ..the cytoskeletal environment of VLA-4 in T cells and its implications in in situ chemokine stimulation of VLA-4 adhesiveness at endothelial contacts...
  36. p120 catenin/VE-cadherin interaction in angiogenesis
    Andres Ferber; Fiscal Year: 2005
    ..The interaction between VE-cadherin and p120ctn seems to modulate cell growth and adhesiveness. We proposed to further characterize the role of the VE-cadherin -p120ctn interaction in regulating cellular ..
    Alan Wells; Fiscal Year: 2003
    ..factors and ELR-CXC chemokines promoted or limited cell motility, respectively, by affecting cell-substratum adhesiveness, and that this was mediated by activation, or inhibition thereof, of calpain...
    Stefano Fiore; Fiscal Year: 1999
    ..Lipoxin A4-induced modifications endothelium cell adhesiveness, proliferation, cytokine generation and release will be specific objectives...
    MALCOLM STEINBERG; Fiscal Year: 1991
    ..indicate that the information system guiding these cells displays the formal properties of a gradient of adhesiveness. A "Cell Guidance Associated Molecule" (CGAM) is predicted to map to the putative gradient...
    Robert Liddington; Fiscal Year: 2003
    ..In addition, we have proposed that the adhesiveness of A domains is dependent on tertiary structure changes within the A domain ("shape-shifting") that create a ..
    Robert Webster; Fiscal Year: 1990
    ..In contrast to augmentation of natural host defense to infection, the intensified adhesiveness and aggregation of neutrophils noted with hemodialysis leukopenia has been suggested to result in the ..
    Celso Bianco; Fiscal Year: 1980
    ..these observations by: (a) studying the correlations between macrophage spreading, inhbition of migration and adhesiveness to a substrate on one hand and cellular locomotion on the other hand; (b) establishing the required temporal ..
  43. Leuko-polymersomes for Optical Imaging
    Daniel Hammer; Fiscal Year: 2007
    ..under flow; 2) to engineer the material properties of the membrane, through polymer synthesis, to modulate the adhesiveness of the polymersomes; and 3) to incorporate a spectrum of large, hydrophobic near-IR dyes within the membrane of ..
    Frederick Grinnell; Fiscal Year: 1992
    Cellular adhesiveness is a fundamental feature of cell behavior. The long-term goal of my research is to determine the mechanisms underlying cell adhesion to extracellular substrata...
    Rakesh Jain; Fiscal Year: 1999
    ..lymphocytes will be studied by direct visualization in normal and tumor microcirculations and related to their adhesiveness and deformability...
  46. Regulation of inflammation: sheddases and CD62L
    Bruce Walcheck; Fiscal Year: 2009
    ..turn, these events appear to control leukocyte recruitment in different ways, such as by influencing L-selectin adhesiveness upon neutrophil attachment to the vascular wall and by maintaining soluble L-selectin in the serum as an ..
  47. Pressure stimulated cell adhesion
    Marc Basson; Fiscal Year: 2009
    ..We propose that signals within tumor cells interact with the cytoskeleton to modify the adhesiveness of cell surface receptors required for adhesion and metastasis...
  48. Role of Integrins During Heart Valve Development
    Scott Klewer; Fiscal Year: 2007
    ..form of congenital heart disease, and computer modeling predicts these defects can result from altered cell adhesiveness. While considerable progress has been made in understanding how multiple families of growth factors regulate ..
    Robert Brackenbury; Fiscal Year: 1992
    ..cells by Rous sarcoma virus (RSV) results in a dramatic reduction in amount of N-CAM and associated cell adhesiveness together with an increase in cell motility...
  50. Cell Motility in Prostate Tumor Invasion
    Douglas Lauffenburger; Fiscal Year: 2004
    ..At least two major biophysical processes are primary governors of cell locomotion: (1) cell/substratum adhesiveness, and (2) cell contractile force. We will employ a set of model cell types to test key hypotheses...
    Druie Cavender; Fiscal Year: 1991
    ..the spread of chronic inflammatory lesions, 3) by characterizing T cell subpopulations with varying degrees of adhesiveness for EC with regard to their chemotactic responsiveness, their cell-surface expression of LFA-1 and very late ..
    TIEN WEN WIEDMANN; Fiscal Year: 1990
    ..These WGA-R cells express altered membrane glycosylation, altered cell adhesiveness, and reduced malignant potential...
    Robert Turner; Fiscal Year: 1980
    The membrane changes involved in the developmentally programmed decrease in cell adhesiveness that accompanies sea urchin embryo primary mesenchyme formation are being subjected to continued biochemical analysis...
    Michael Marmor; Fiscal Year: 1993
    ..We will use physiological techniques to measure the adhesiveness of the SRS, to create experimental detachments, and to monitor electrophysiologically the function of retina ..
  55. ICAM-1 rearrangement and leukocyte-endothelial adhesion
    Dennis Kucik; Fiscal Year: 2004
    ..This involves control adhesiveness of both the leukocyte and the endothelial cell to which it adheres...
  56. Signaling pathways activating adhesion in sickle cells
    LESLIE PARISE; Fiscal Year: 2005
    Agonist-induced signaling is a primary mechanism regulating adhesiveness of platelets, leukocytes and other cells...
    Erkki Ruoslahti; Fiscal Year: 2002
    ..They may also explain how malignant cells down-regulate their adhesiveness and increase their ability to migrate and invade...
    TIMOTHY O TOOLE; Fiscal Year: 1999
    ..In response to external stimuli, integrins upregulate ligand binding affinity and alter cellular adhesiveness. Preliminary data suggest that integrin "activation" or affinity modulation involves cell- specific signalling ..
  59. The Role of VILIP-1 in Development of Skin Tumors
    Andres Klein Szanto; Fiscal Year: 2007
    ..In this experiment, we will study cell proliferation, differentiation, adhesiveness, migration and invasiveness of VILIP-1 transfectants and knocked-down SCC cells in the context of cyclic ..
    Timothy Springer; Fiscal Year: 2003
    ..Studies of the function of these molecules in health and disease, the regulation of adhesiveness through them, and the structure of their interaction sites is of great importance, and may lead to the ..
    Sahebarao Mahadik; Fiscal Year: 1992
    ..3. To identify the possible molecular mechanisms associated with abnormal growth parameters: the adhesiveness to plastic substratum, the levels of fibronectin and the growth response to growth factors, e.g...
    Jayalakshmi Vaidyanathan; Fiscal Year: 2006
    ..Binding studies between the ligands and collagen will be conducted by:1) a novel immunochemical binding assay developed by us; and 2) isothermal titration calorimetry, and related to computed interaction energy values. ..