surface properties

Summary

Top Publications

  1. ncbi Mediation of biomaterial-cell interactions by adsorbed proteins: a review
    Cameron J Wilson
    Tissue BioRegeneration Domain, Institute of Health and Biomedical Innovation, School of Engineering Systems, Queensland University of Technology, Brisbane, Queensland, Australia
    Tissue Eng 11:1-18. 2005
  2. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
  3. ncbi Effect of surface properties on nanoparticle-cell interactions
    Ayush Verma
    Department of Materials Science and Engineering, Massachusetts Institute of Technology MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Small 6:12-21. 2010
  4. ncbi The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder
    Matthew J Dalby
    Centre for Cell Engineering, Joseph Black Building, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK
    Nat Mater 6:997-1003. 2007
  5. pmc Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
    Martin Lundqvist
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
    Proc Natl Acad Sci U S A 105:14265-70. 2008
  6. pmc Factors affecting the clearance and biodistribution of polymeric nanoparticles
    Frank Alexis
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Pharm 5:505-15. 2008
  7. ncbi Design and self-assembly of two-dimensional DNA crystals
    E Winfree
    Computation and Neural Systems, California Institute of Technology, Pasadena 91125, USA
    Nature 394:539-44. 1998
  8. ncbi Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
    Tony Yeung
    Institute for Medicine and Engineering, University of Pennsylvania, PA 19104, USA
    Cell Motil Cytoskeleton 60:24-34. 2005
  9. ncbi Exploring and engineering the cell surface interface
    Molly M Stevens
    Department of Materials and Institute for Biomedical Engineering, Imperial College of Science, Technology, and Medicine, Prince Consort Road, London SW7 2BP, UK
    Science 310:1135-8. 2005
  10. ncbi Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles
    Chunbai He
    State Key Laboratory of Genetic Engineering, Department of Pharmaceutical Sciences, School of Life Sciences, Fudan University, Shanghai 200433, China
    Biomaterials 31:3657-66. 2010

Detail Information

Publications367 found, 100 shown here

  1. ncbi Mediation of biomaterial-cell interactions by adsorbed proteins: a review
    Cameron J Wilson
    Tissue BioRegeneration Domain, Institute of Health and Biomedical Innovation, School of Engineering Systems, Queensland University of Technology, Brisbane, Queensland, Australia
    Tissue Eng 11:1-18. 2005
    ..Hence, one of the key issues yet to be resolved is that of the interface composition actually encountered by osteoblasts within the sequence of inflammation and bone regeneration...
  2. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
    ..The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable...
  3. ncbi Effect of surface properties on nanoparticle-cell interactions
    Ayush Verma
    Department of Materials Science and Engineering, Massachusetts Institute of Technology MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Small 6:12-21. 2010
    ..These applications require a firm control over nanoparticle-cell interactions, which are mainly dictated by surface properties of nanoparticles...
  4. ncbi The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder
    Matthew J Dalby
    Centre for Cell Engineering, Joseph Black Building, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK
    Nat Mater 6:997-1003. 2007
    ..In addition, the current studies show that topographically treated MSCs have a distinct differentiation profile compared with those treated with osteogenic media, which has implications for cell therapies...
  5. pmc Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
    Martin Lundqvist
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
    Proc Natl Acad Sci U S A 105:14265-70. 2008
    ..the long-lived ("hard") protein corona formed from human plasma for a range of nanoparticles that differ in surface properties and size...
  6. pmc Factors affecting the clearance and biodistribution of polymeric nanoparticles
    Frank Alexis
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Pharm 5:505-15. 2008
    ....
  7. ncbi Design and self-assembly of two-dimensional DNA crystals
    E Winfree
    Computation and Neural Systems, California Institute of Technology, Pasadena 91125, USA
    Nature 394:539-44. 1998
    ..The patterned crystals have been visualized by atomic force microscopy...
  8. ncbi Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
    Tony Yeung
    Institute for Medicine and Engineering, University of Pennsylvania, PA 19104, USA
    Cell Motil Cytoskeleton 60:24-34. 2005
    ..These results support the hypothesis that mechanical factors impact different cell types in fundamentally different ways, and can trigger specific changes similar to those stimulated by soluble ligands...
  9. ncbi Exploring and engineering the cell surface interface
    Molly M Stevens
    Department of Materials and Institute for Biomedical Engineering, Imperial College of Science, Technology, and Medicine, Prince Consort Road, London SW7 2BP, UK
    Science 310:1135-8. 2005
    ..Far-reaching implications are emerging for applications including medical implants, cell supports, and materials that can be used as instructive three-dimensional environments for tissue regeneration...
  10. ncbi Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles
    Chunbai He
    State Key Laboratory of Genetic Engineering, Department of Pharmaceutical Sciences, School of Life Sciences, Fudan University, Shanghai 200433, China
    Biomaterials 31:3657-66. 2010
    ..These results could serve as a guideline in the rational design of drug nanocarriers with maximized therapeutic efficacy and predictable in vivo properties, in which the control of particle size and surface charge was of significance...
  11. ncbi Ultra-large-scale syntheses of monodisperse nanocrystals
    Jongnam Park
    National Creative Research Center for Oxide Nanocrystalline Materials and School of Chemical Engineering, Seoul National University, Seoul 151 744, Korea
    Nat Mater 3:891-5. 2004
    ..The current synthetic procedure is very general and nanocrystals of many transition metal oxides were successfully synthesized using a very similar procedure...
  12. ncbi Evolution of graphene growth on Ni and Cu by carbon isotope labeling
    Xuesong Li
    Department of Mechanical Engineering and the Texas Materials Institute, 1 University Station C2200, The University of Texas at Austin, Austin, Texas 78712 0292, USA
    Nano Lett 9:4268-72. 2009
    ..This data is critical in guiding the graphene growth process as we try to achieve the highest quality graphene for electronic devices...
  13. ncbi Surface treatments of titanium dental implants for rapid osseointegration
    L Le Guehennec
    INSERM U791, LIOAD, Osteoarticular and Dental Tissue Engineering, Faculty of Dental Surgery, 1 Place Alexis Ricordeau, 44042 Nantes Cedex 1, France
    Dent Mater 23:844-54. 2007
    ..These therapeutic strategies should ultimately enhance the osseointegration process of dental implants for their immediate loading and long-term success...
  14. ncbi Self-assembled monolayers of thiolates on metals as a form of nanotechnology
    J Christopher Love
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Chem Rev 105:1103-69. 2005
  15. ncbi Interfaces and the driving force of hydrophobic assembly
    David Chandler
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Nature 437:640-7. 2005
    ..Despite the basic principles underlying the hydrophobic effect being qualitatively well understood, only recently have theoretical developments begun to explain and quantify many features of this ubiquitous phenomenon...
  16. pmc Size, charge and concentration dependent uptake of iron oxide particles by non-phagocytic cells
    Daniel L J Thorek
    Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, PA 19104, USA
    Biomaterials 29:3583-90. 2008
    ..5microm, with precisely controlled surface properties, and without the need for transfection agents...
  17. ncbi Graphene thickness determination using reflection and contrast spectroscopy
    Z H Ni
    Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542
    Nano Lett 7:2758-63. 2007
    ..We also show that the refractive index of graphene is different from that of graphite. The results are compared with those obtained using Raman spectroscopy...
  18. pmc Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles
    Ayush Verma
    Department of Materials Science and Engineering, MIT, Massachusetts 02139, USA
    Nat Mater 7:588-95. 2008
    ..Our results offer a paradigm for analysing the fundamental problem of cell-membrane-penetrating bio- and macro-molecules...
  19. ncbi Antifouling coatings: recent developments in the design of surfaces that prevent fouling by proteins, bacteria, and marine organisms
    Indrani Banerjee
    Howard P Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Adv Mater 23:690-718. 2011
    ..While considerable progress has been made in the design of antifouling coatings, ongoing research in this area should result in the development of even better antifouling materials in the future...
  20. ncbi Cellular uptake, cytotoxicity, and innate immune response of silica-titania hollow nanoparticles based on size and surface functionality
    Wan Kyu Oh
    School of Chemical and Biological Engineering, Seoul National University, 599 Gwanangro, Gwanak Gu, Seoul 151 742, Korea
    ACS Nano 4:5301-13. 2010
    ..These findings provide size- and surface functionality-dependent nanotoxicity and uptake of HNPs, and lead to HNPs for bioapplications such as drug delivery and imaging probe...
  21. pmc Adhesion of osteoblasts to a nanorough titanium implant surface
    Ekaterina Gongadze
    Institute of General Electrical Engineering, University of Rostock, Rostock, Germany
    Int J Nanomedicine 6:1801-16. 2011
    ..It is therefore plausible that nanorough regions of titanium surfaces with sharp edges and spikes promote the adhesion of osteoblasts...
  22. ncbi Improved bone-forming functionality on diameter-controlled TiO(2) nanotube surface
    Karla S Brammer
    Materials Science and Engineering, University of California, San Diego, La Jolla, CA 92093 0411, USA
    Acta Biomater 5:3215-23. 2009
    ....
  23. ncbi Plant surface properties in chemical ecology
    Caroline Muller
    Julius von Sachs Institut fur Biowissenschaften, Universitat Wurzburg, Julius von Sachs Platz 3, D 97082 Wurzburg, Germany
    J Chem Ecol 31:2621-51. 2005
    ..Here, we summarize current knowledge about the physical and chemical properties of plant cuticles and their role in interactions with microorganisms, phytophagous insects, and their antagonists...
  24. ncbi Assessing the effect of surface chemistry on gold nanorod uptake, toxicity, and gene expression in mammalian cells
    Tanya S Hauck
    Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, 4th floor Toronto, ON M5S 3E1, Canada
    Small 4:153-9. 2008
    ..35% of genes examined). These results indicate that gold nanorods are well suited for therapeutic applications, such as thermal cancer therapy, due to their tunable cell uptake and low toxicity...
  25. ncbi Surface properties of sludge and their role in bioflocculation and settleability
    B Q Liao
    Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario, Canada M5S 3E5
    Water Res 35:339-50. 2001
    ..was associated with a larger amount of total EPS but no significant correlation between SVI and the surface properties of sludge was observed...
  26. ncbi Chemistry of aqueous silica nanoparticle surfaces and the mechanism of selective peptide adsorption
    Siddharth V Patwardhan
    Interdisciplinary Biomedical Research Centre, School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK
    J Am Chem Soc 134:6244-56. 2012
    ..Follow-on questions about the relation between peptide adsorption on silica nanoparticles and mineralization of silica from peptide-stabilized precursors are raised...
  27. ncbi New approaches to nanofabrication: molding, printing, and other techniques
    Byron D Gates
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Chem Rev 105:1171-96. 2005
  28. pmc Stresses at the cell-to-substrate interface during locomotion of fibroblasts
    M Dembo
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215 2407, USA
    Biophys J 76:2307-16. 1999
    ..These observations demonstrate that the lamellipodium of the fibroblast is able to generate intense traction stress. The cell body and posterior seem to be mechanically passive structures pulled forward entirely by this action...
  29. ncbi Osteoprogenitor response to semi-ordered and random nanotopographies
    Matthew John Dalby
    Centre for Cell Engineering, Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, UK
    Biomaterials 27:2980-7. 2006
    ..The results demonstrated that the nanotopographies stimulated the osteoprogenitor cell differentiation towards an osteoblastic phenotype...
  30. pmc A second quorum-sensing system regulates cell surface properties but not phenazine antibiotic production in Pseudomonas aureofaciens
    Z Zhang
    Department of Plant Pathology, University of Arizona, Tucson, Arizona 85721, USA
    Appl Environ Microbiol 67:4305-15. 2001
    ..These data suggest that gene(s) regulated by the CsaR-CsaI system also plays a role in the rhizosphere competence of P. aureofaciens 30-84...
  31. ncbi Biological factors contributing to failures of osseointegrated oral implants. (II). Etiopathogenesis
    M Esposito
    Institute of Anatomy and Cell Biology, Goteborg University, Sweden
    Eur J Oral Sci 106:721-64. 1998
    ..Furthermore, it appears that implant surface properties (roughness and type of coating) may influence the failure pattern...
  32. pmc The role of surface charge on the uptake and biocompatibility of hydroxyapatite nanoparticles with osteoblast cells
    Liang Chen
    Department of Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO 65211, USA
    Nanotechnology 22:105708. 2011
    ..These in vitro results may also provide useful information for investigations of HAP nanoparticle applications in gene delivery and intracellular drug delivery...
  33. ncbi Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique
    Richard C Murdock
    Applied Biotechnology Branch, Human Effectiveness Directorate Air Force Research Laboratory HEPB, Wright Patterson Air Force Board, Ohio 45433, USA
    Toxicol Sci 101:239-53. 2008
    ..Observations of material-specific surface properties were also recorded...
  34. pmc Surface-charge-dependent cell localization and cytotoxicity of cerium oxide nanoparticles
    Atul Asati
    NanoScience Technology Center, Suite 400, 12424 Research Parkway, Orlando, Florida 32826, USA
    ACS Nano 4:5321-31. 2010
    ..Taken together, these results indicate that the differential surface-charge-dependent localization of nanoceria in normal and cancer cells plays a critical role in the nanoparticles' toxicity profile...
  35. ncbi Dental microwear texture analysis shows within-species diet variability in fossil hominins
    Robert S Scott
    1 Department of Anthropology, University of Arkansas, Fayetteville, Arkansas 72701, USA 2 These authors contributed equally to this work
    Nature 436:693-5. 2005
    ..africanus. This suggests that A. africanus ate more tough foods and P. robustus consumed more hard and brittle items, but that both had variable and overlapping diets...
  36. ncbi Increased osteoblast adhesion on nanophase metals: Ti, Ti6Al4V, and CoCrMo
    Thomas J Webster
    Department of Biomedical Engineering, Purdue University, 1296Patter Building, West Lafayette, IN 47905, USA
    Biomaterials 25:4731-9. 2004
    ....
  37. pmc Physical approaches to biomaterial design
    Samir Mitragotri
    Department of Chemical Engineering, University of California Santa Barbara, California 93106, USA
    Nat Mater 8:15-23. 2009
    ..In each case, we present examples demonstrating the significance of these properties in biology. We also discuss synthesis methods and biological applications for designer biomaterials, which offer unique physical properties...
  38. ncbi The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles in 3T3-L1 cells and human mesenchymal stem cells
    Tsai Hua Chung
    Stem Cell Research Center, National Health Research Institutes, Miaoli 350, Taiwan, ROC
    Biomaterials 28:2959-66. 2007
    ..Our results show that MSNs uptake by hMSCs can be regulated by a threshold of positive surface charge but also imply that the modulation of surface charge on MSNs uptake is specific to cell type...
  39. ncbi Switchable adhesive substrates: revealing geometry dependence in collective cell behavior
    Claudio G Rolli
    Department New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Stuttgart, Germany
    Biomaterials 33:2409-18. 2012
    ..Additionally, we observe that collective migration characteristics are modulated by the initial incubation time of the cell sheet...
  40. ncbi Cellular uptake and cytotoxicity of gold nanorods: molecular origin of cytotoxicity and surface effects
    Alaaldin M Alkilany
    Department of Chemistry and Biochemistry University of South Carolina Columbia, SC 29208, USA
    Small 5:701-8. 2009
    ..The results suggest that physiochemical surface properties of nanomaterials change substantially after coming into contact with biological media...
  41. ncbi Wear mechanisms in metal-on-metal bearings: the importance of tribochemical reaction layers
    Markus A Wimmer
    Department of Orthopedic Surgery, Rush University Medical Center, 1653 West Congress Parkway, Chicago, Illinois 60612, USA
    J Orthop Res 28:436-43. 2010
    ..This novel finding of a mechanically mixed zone of nanocrystalline metal and organic constituents provides the basis for understanding particle release and may help in identifying new strategies to reduce MoM wear...
  42. ncbi Effect of material characteristics and/or surface topography on biofilm development
    Wim Teughels
    Department of Periodontology, Faculty of Medicine, School of Dentistry, Oral Pathology and Maxillo Facial Surgery, Catholic University of Leuven, Leuven, Belgium
    Clin Oral Implants Res 17:68-81. 2006
    ..An uncontrolled accumulation and/or metabolism of bacteria on the hard surfaces forms, however, the primary cause of dental caries, gingivitis, periodontitis, peri-implantitis, and stomatitis...
  43. ncbi Prediction of TiO2 nanoparticle phase and shape transitions controlled by surface chemistry
    A S Barnard
    Center for Nanoscale Materials, Materials Science Division, Argonne National Laboratory, 9700 South Cass Ave, Argonne, Illinois 60439, USA
    Nano Lett 5:1261-6. 2005
    ..The latter introduces the possibility of inducing phase transitions by changing the surface chemistry...
  44. ncbi The influence of surface functionalization on the enhanced internalization of magnetic nanoparticles in cancer cells
    Angeles Villanueva
    Departamento de Biologia, Universidad Autonoma de Madrid, Madrid, Spain
    Nanotechnology 20:115103. 2009
    ....
  45. ncbi Protein adsorption onto silica nanoparticles: conformational changes depend on the particles' curvature and the protein stability
    Martin Lundqvist
    Molecular Biotechnology IFM, Linkoping University, SE 58183 Linkoping, Sweden
    Langmuir 20:10639-47. 2004
    ..In contrast, the effects on the tertiary structure seem to be independent of the particles' curvature...
  46. pmc Nanopattern-induced changes in morphology and motility of smooth muscle cells
    Evelyn K F Yim
    Department of Biomedical Engineering, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Biomaterials 26:5405-13. 2005
    ..It is proposed that this nanoimprinting technology will provide a valuable platform for studies in cell-substrate interactions and for development of medical devices with nanoscale features...
  47. ncbi Carbon nanotubes with high bone-tissue compatibility and bone-formation acceleration effects
    Yuki Usui
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto Nagano 390 8621, Japan
    Small 4:240-6. 2008
    ..These findings should encourage development of clinical treatment modalities involving CNTs...
  48. ncbi The influence of hierarchical hybrid micro/nano-textured titanium surface with titania nanotubes on osteoblast functions
    Lingzhou Zhao
    School of Stomatology, The Fourth Military Medical University, No 145 West ChangLe Road, Xi an 710032, China
    Biomaterials 31:5072-82. 2010
    ..Our study reveals a synergistic role played by the micro and nanotopographies in osteoblast functions and provides insight to the design of better biomedical implant surfaces...
  49. ncbi Age-dependent degradation of the protein adsorption capacity of titanium
    N Hori
    Laboratory for Bone and Implant Sciences, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry, Los Angeles, CA 90095 1668, USA
    J Dent Res 88:663-7. 2009
    ..This time-dependent degradation in protein adsorption of titanium correlated with its naturally decreasing hydrophilicity, which was not observed for the nickel and chromium surfaces, indicating a titanium-specific biological aging...
  50. ncbi Time-dependent degradation of titanium osteoconductivity: an implication of biological aging of implant materials
    Wael Att
    Laboratory of Bone and Implant Sciences, The Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry, Los Angeles, CA 90095 1668, USA
    Biomaterials 30:5352-63. 2009
    ..We also suggest possible underlying mechanisms for this biological degradation that provide new insights into how we could inadvertently lose, and conversely, maximize the osteoconductivity of titanium-based implant materials...
  51. ncbi Enhancing surface free energy and hydrophilicity through chemical modification of microstructured titanium implant surfaces
    F Rupp
    Department of Prosthetic Dentistry, Section Medical Materials and Technology, University Hospital Tuebingen, Osianderstrasse 2 8, D 72076 Tuebingen, Germany
    J Biomed Mater Res A 76:323-34. 2006
    ....
  52. ncbi Advancing dental implant surface technology--from micron- to nanotopography
    Gustavo Mendonça
    Universidade Catolica de Brasilia, Pos Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av W5 Norte 70 790 160 Brasília, DF, Brazil
    Biomaterials 29:3822-35. 2008
    ..Nanoscale modification of titanium endosseous implant surfaces can alter cellular and tissue responses that may benefit osseointegration and dental implant therapy...
  53. pmc Requirement for both micron- and submicron scale structure for synergistic responses of osteoblasts to substrate surface energy and topography
    G Zhao
    Georgia Institute of Technology, Atlanta, GA, USA
    Biomaterials 28:2821-9. 2007
    ..This study tested the hypothesis that the synergistic response of osteoblasts to these modified surfaces depends on both surface micro-structure and surface energy...
  54. ncbi Biofilm on dental implants: a review of the literature
    Karthikeyan Subramani
    Department of Fixed and Removable Prosthodontics and Dental Material Science, Center for Dental and Oral Medicine and Cranio maxillofacial Surgery, University of Zurich, Switzerland
    Int J Oral Maxillofac Implants 24:616-26. 2009
    ....
  55. ncbi Effects of titanium surface topography on bone integration: a systematic review
    Ann Wennerberg
    Department of Prosthodontics, Faculty of Odontology, Malmo University, Malmo, Sweden
    Clin Oral Implants Res 20:172-84. 2009
    ..To analyse possible effects of titanium surface topography on bone integration...
  56. pmc Nano rough micron patterned titanium for directing osteoblast morphology and adhesion
    Sabrina Puckett
    Division of Engineering, Brown University, Providence, RI 02917, USA
    Int J Nanomedicine 3:229-41. 2008
    ....
  57. ncbi Antibacterial coatings on titanium implants
    Lingzhou Zhao
    School of Stomatology, The Fourth Military Medical University, Xi an 710072, People s Republic of China
    J Biomed Mater Res B Appl Biomater 91:470-80. 2009
    ..One important strategy is to render the implant surface antibacterial by impeding the formation of a biofilm. A number of approaches have been proposed for this purpose and they are reviewed in this article...
  58. pmc A Staphylococcus aureus ypfP mutant with strongly reduced lipoteichoic acid (LTA) content: LTA governs bacterial surface properties and autolysin activity
    Iris Fedtke
    Cellular and Molecular Microbiology Division, University of Tubingen, Department of Medical Microbiology and Hygiene, 72076 Tubingen, Germany
    Mol Microbiol 65:1078-91. 2007
    ..We propose to consider LTA and its biosynthetic enzymes as targets for new antibiofilm strategies...
  59. ncbi A generalized ligand-exchange strategy enabling sequential surface functionalization of colloidal nanocrystals
    Angang Dong
    Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
    J Am Chem Soc 133:998-1006. 2011
    The ability to engineer surface properties of nanocrystals (NCs) is important for various applications, as many of the physical and chemical properties of nanoscale materials are strongly affected by the surface chemistry...
  60. ncbi The influence of nano-scale surface roughness on bacterial adhesion to ultrafine-grained titanium
    Vi K Truong
    Swinburne University of Technology, PO Box 218, Hawthorn, Victoria 3122, Australia
    Biomaterials 31:3674-83. 2010
    ..aeruginosa, while also showing some preference for the ECAP-processed material, was less sensitive to the ECAP processing...
  61. ncbi In vivo evaluation of anodic TiO2 nanotubes: an experimental study in the pig
    Cornelius von Wilmowsky
    Department of Oral and Maxillofacial Surgery, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    J Biomed Mater Res B Appl Biomater 89:165-71. 2009
    ..Because of their simple, low cost, flexible manufacturing and the possibility for the usage as drug or growth factor delivery system, nanotubes seem to be a promising method for future medical implant coatings...
  62. ncbi Electrospun fibers immobilized with bone forming peptide-1 derived from BMP7 for guided bone regeneration
    Young Jun Lee
    Department of Bioengineering, College of Engineering, Hanyang University, Seongdong Gu, Seoul 133 791, Republic of Korea
    Biomaterials 34:5059-69. 2013
    ..24% in the groups implanted with PD-coated PLGA and with BFP1-coated PLGA, respectively. Based on these results, our approach may be a promising tool to develop clinically-applicable bioactive membranes for guided bone regeneration."..
  63. pmc Glycosylation genes expressed in seam cells determine complex surface properties and bacterial adhesion to the cuticle of Caenorhabditis elegans
    Maria J Gravato-Nobre
    Department of Cell and Tissue Biology, University of California, San Francisco, California 94143, USA
    Genetics 187:141-55. 2011
    ..interaction, involving locomotory inhibition by a strain of Bacillus pumilus, reveals diversity in the surface properties of these mutants...
  64. ncbi Surface physicochemical analysis of natural Lactococcus lactis strains reveals the existence of hydrophobic and low charged strains with altered adhesive properties
    Efstathios Giaouris
    Unité mixte de recherche en Bioadhesion et Hygiène des Matériaux, UMR 763 INRA AgroParisTech, 25 avenue de la République, 91300 Massy, France
    Int J Food Microbiol 131:2-9. 2009
    ..A global multivariate analysis of the results revealed a high natural diversity of L. lactis cell surface properties. While 52% of the strains present a hydrophilic and electronegative cell wall surface, a group of strikingly ..
  65. ncbi Effect of zirconium-oxide ceramic surface treatments on the bond strength to adhesive resin
    Saadet Saglam Atsu
    Department of Prosthodontics, Kirikkale University, Faculty of Dental Medicine, Turkey
    J Prosthet Dent 95:430-6. 2006
    ..Surface treatment methods used for resin bonding to conventional silica-based dental ceramics are not reliable for zirconium-oxide ceramics...
  66. ncbi The immobilization of recombinant human tropoelastin on metals using a plasma-activated coating to improve the biocompatibility of coronary stents
    Anna Waterhouse
    School of Molecular Bioscience, University of Sydney, NSW 2006, Australia
    Biomaterials 31:8332-40. 2010
    ..Coatings were characterized for 1) surface properties, 2) mechanical durability, 3) covalent protein binding, 4) endothelial cell interactions and 5) ..
  67. ncbi Enhanced bone apposition to a chemically modified SLA titanium surface
    D Buser
    Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Berne, Freiburgstrasse 7, PO Box 64, 3010 Berne, Switzerland
    J Dent Res 83:529-33. 2004
    ..30 vs. 29.42%; p = 0.017) and 4 wks (81.91 vs. 66.57%; p = 0.011) of healing. At 8 wks, similar results were observed. It is concluded that the modSLA surface promoted enhanced bone apposition during early stages of bone regeneration...
  68. ncbi Cell sensing and response to micro- and nanostructured surfaces produced by chemical and topographic patterning
    Jung Yul Lim
    Division of Musculoskeletal Sciences, Department of Orthopaedics and Rehabilitation, Center for Biomedical Devices and Functional Tissue Engineering, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania, USA
    Tissue Eng 13:1879-91. 2007
    ....
  69. ncbi High surface energy enhances cell response to titanium substrate microstructure
    G Zhao
    Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Biomed Mater Res A 74:49-58. 2005
    ..This suggests that increased bone formation observed on modified Ti surfaces in vivo is due in part to stimulatory effects of high surface energy on osteoblasts...
  70. ncbi Alkyl hydroperoxide reductase has a role in oxidative stress resistance and in modulating changes in cell-surface properties in Azospirillum brasilense Sp245
    Mariam Wasim
    Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    Microbiology 155:1192-202. 2009
    ..had multiple defects in a large array of cellular functions that were consistent with alteration of cell-surface properties, such as cell morphology in stationary phase, Calcofluor White-, Congo Red- and lectin-binding abilities, as ..
  71. ncbi Three-dimensional plasmonic chiral tetramers assembled by DNA origami
    Xibo Shen
    National Center for Nanoscience and Technology, No 11 Beiyitiao, Zhongguancun, Beijing 100190, China
    Nano Lett 13:2128-33. 2013
    ....
  72. pmc Quantitative proteomics analysis of adsorbed plasma proteins classifies nanoparticles with different surface properties and size
    Haizhen Zhang
    Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Proteomics 11:4569-77. 2011
    ..proteomics data resulted in distinctive patterns that classified the nanoparticles based on their surface properties and size...
  73. ncbi Tailoring the surface properties of Ti6Al4V by controlled chemical oxidation
    Fabio Variola
    Institut National de la Recherche Scientifique Energie, Materiaux et Telecommunications, Universite du Quebec, Varennes, Quebec J3X 1S2, Canada
    Biomaterials 29:1285-98. 2008
    ..The resulting new surfaces selectively promote the growth of osteoblasts while inhibiting that of fibroblasts, making them promising tools for regulating the activities of cells in biological environments...
  74. ncbi Graphene-based liquid crystal device
    Peter Blake
    School of Computer Science, University of Manchester, Manchester, UK
    Nano Lett 8:1704-8. 2008
    ..We also discuss the advantages of graphene compared to conventionally used metal oxides in terms of low resistivity, high transparency and chemical stability...
  75. ncbi Interfacing silicon nanowires with mammalian cells
    Woong Kim
    The Molecular Foundry and Materials Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    J Am Chem Soc 129:7228-9. 2007
  76. ncbi Oral implant surfaces: Part 2--review focusing on clinical knowledge of different surfaces
    Tomas Albrektsson
    Department of Biomaterials Handicap Research, Institute for Surgical Sciences, Goteborg University, Sweden
    Int J Prosthodont 17:544-64. 2004
    ..This article reviews clinical knowledge of selected oral implant surfaces...
  77. ncbi Surface engineering approaches to micropattern surfaces for cell-based assays
    Didier Falconnet
    BioInterfaceGroup, Laboratory for Surface Science and Technology, Department of Materials, Swiss Federal Institute of Technology ETH Zurich, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    Biomaterials 27:3044-63. 2006
    ....
  78. ncbi Enhanced osteoblast functions on anodized titanium with nanotube-like structures
    Chang Yao
    School of Materials Engineering, 500 Central Drive, Purdue University, West Lafayette, Indiana 47907 2022, USA
    J Biomed Mater Res A 85:157-66. 2008
    ....
  79. ncbi The interaction of cells and bacteria with surfaces structured at the nanometre scale
    K Anselme
    Institut de Sciences des Materiaux de Mulhouse, CNRS LRC, Universite de Haute Alsace, Mulhouse, France
    Acta Biomater 6:3824-46. 2010
    ....
  80. pmc Generating triangulated macromolecular surfaces by Euclidean Distance Transform
    Dong Xu
    Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 4:e8140. 2009
    ..Both source code and the executable program of EDTSurf are freely available at http://zhang.bioinformatics.ku.edu/EDTSurf...
  81. ncbi Transfer-free electrical insulation of epitaxial graphene from its metal substrate
    Silvano Lizzit
    Sincrotrone Trieste, S S 14 Km 163 5, 34149 Trieste, Italy
    Nano Lett 12:4503-7. 2012
    ..We follow the reaction steps by X-ray photoemission spectroscopy and demonstrate the electrical insulation using a nanoscale multipoint probe technique...
  82. ncbi Effect of subinhibitory concentration of piperacillin/tazobactam on Pseudomonas aeruginosa
    A P Fonseca
    Department of Microbiology, Faculty of Medicine, University of Porto, Portugal
    J Med Microbiol 53:903-10. 2004
    ..The results obtained indicate that sub-MIC P/T interferes with the pathogenic potential of P. aeruginosa...
  83. ncbi Topography effects of pure titanium substrates on human osteoblast long-term adhesion
    K Anselme
    Laboratoire de Recherche sur les Biomatériaux et les Biotechnologies, Universite du Littoral Cote d Opale, 52 rue du Dr Calot, 62608 Berck sur Mer Cedex, France
    Acta Biomater 1:211-22. 2005
    ..Its correlation with the order parameter, which describes the organization of the roughness, confirmed once more that human osteoblasts are more sensitive to the organization and morphology of the roughness than to its amplitude...
  84. pmc Reduced adhesion of macrophages on anodized titanium with select nanotube surface features
    Amancherla Rajyalakshmi
    Non Ferrous Materials Technology Development Centre, Hyderabad, India
    Int J Nanomedicine 6:1765-71. 2011
    ..This in vitro study thus demonstrated a reduced density of macrophages on anodized Ti, thereby providing further evidence of the greater efficacy of anodized Ti for orthopedic applications...
  85. ncbi DNA surface hybridization: comparison of theory and experiment
    Damion Irving
    Department of Chemical and Biological Engineering, Polytechnic Institute of New York University, Brooklyn, New York 11201, USA
    J Phys Chem B 114:7631-40. 2010
    ..By delineating conditions under which specific hybridization behaviors are observed, the results advance fundamental knowledge in support of DNA microarray and biosensor applications...
  86. pmc Insect aquaplaning: Nepenthes pitcher plants capture prey with the peristome, a fully wettable water-lubricated anisotropic surface
    Holger F Bohn
    Zoologie II, Biozentrum, Am Hubland, 97074 Wurzburg, Germany
    Proc Natl Acad Sci U S A 101:14138-43. 2004
    ..It is based on special surface properties of the pitcher rim (peristome) and insect "aquaplaning...
  87. ncbi Nanotechnology: pediatric applications
    Mary C Machado
    Division of Engineering, Brown University, Providence, Rhode Island 02919, USA
    Pediatr Res 67:500-4. 2010
    ..This review seeks to examine the antimicrobial properties of both nanoparticles and nanomodified surfaces and to characterize their effectiveness at reducing bacterial colonization on ETT...
  88. ncbi Geometric control of stem cell differentiation rate on surfaces
    Wei Luo
    Department of Chemistry and Carolina Center for Genome Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3290, USA
    Langmuir 24:12129-33. 2008
    ..Furthermore, the cells within the pattern behave more characteristically of a tissue than do individual cells because a certain critical threshold cell density is required to induce differentiation...
  89. ncbi Mechanical and histological evaluation of a PMMA-based bone cement modified with gamma-methacryloxypropyltrimethoxysilane and calcium acetate
    Tadashi Tsukeoka
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Biomaterials 27:3897-903. 2006
    ..The modification was found to be effective in enabling osteoconduction with PMMA bone cement, thus providing stable fixation for a long period after implantation...
  90. ncbi Thickness of multiwalled carbon nanotubes affects their lung toxicity
    Ivana Fenoglio
    Dipartimento di Chimica, Universita degli Studi di Torino, Via P Giuria 7, Torino 10125, Italy
    Chem Res Toxicol 25:74-82. 2012
    ..The data reported herein suggest that the nanotube diameter is an important parameter to be considered in the toxicological assessment of CNTs...
  91. ncbi Bacterial adhesion on PEG modified polyurethane surfaces
    K D Park
    Biomaterials Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea
    Biomaterials 19:851-9. 1998
    ..These results suggest that surface modification with PEG1k-SO3, PEG3.4k and PEG3.4k-heparin seems to be effective for prevention of bacterial adhesion and subsequent infection...
  92. ncbi Highly selective directed assembly of functional actomyosin on Au surfaces
    Pradeep Manandhar
    Langmuir 21:3213-6. 2005
    ..In vitro motility assays of filament sliding were used to confirm functionality of assembled actomyosin...
  93. ncbi Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model
    Camilla Foged
    Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Int J Pharm 298:315-22. 2005
    ..we investigated DC uptake of model fluorescent polystyrene particles with a broad size range and variable surface properties. Localization of particles was investigated using confocal laser scanning microscopy and uptake was ..
  94. ncbi BSA adsorption on differently charged polystyrene nanoparticles using isothermal titration calorimetry and the influence on cellular uptake
    Grit Baier
    Max Planck Institute for Polymer Research, Mainz, Germany
    Macromol Biosci 11:628-38. 2011
    ..The cellular uptake of particles before and after BSA adsorption was studied using HeLa cells in the presence and absence of supplemented FCS in the cell culture medium...
  95. ncbi Improved current extraction from ZnO/PbS quantum dot heterojunction photovoltaics using a MoO3 interfacial layer
    Patrick R Brown
    Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Nano Lett 11:2955-61. 2011
    ..5-fold, 2.3-fold, and 4.5-fold enhancements in photovoltaic device efficiency for gold, silver, and ITO anodes, respectively, and result in a power conversion efficiency of 3.5 ± 0.4% for a device employing a gold anode...
  96. ncbi A carpet cloak for visible light
    Majid Gharghi
    NSF Nanoscale Science and Engineering Center, University of California, Berkeley 3112 Etcheverry Hall, UC Berkeley, California 94720, United States
    Nano Lett 11:2825-8. 2011
    ..This silicon nitride on low index substrate can also be a general scheme for implementation of transformation optical devices at visible frequencies...
  97. ncbi Selective assembly and guiding of actomyosin using carbon nanotube network monolayer patterns
    Kyung Eun Byun
    Physics and Astronomy, Seoul National University, Shilim Dong, Kwanak gu, Seoul, Korea
    Langmuir 23:9535-9. 2007
    ..This strategy is advantageous over previous methods because it does not require complicated biomolecular linking processes and nonbiological nanostructures are usually more stable than biomolecular linkers...
  98. ncbi Design and ocular tolerance of flurbiprofen loaded ultrasound-engineered NLC
    E Gonzalez-Mira
    Department of Physical Chemistry, Faculty of Pharmacy, Institute of Nanoscience and Nanotechnology, University of Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
    Colloids Surf B Biointerfaces 81:412-21. 2010
    ..The developed systems were shown physico-chemically stable with high tolerance for eye instillation...
  99. ncbi Tuning cell adhesion by controlling the roughness and wettability of 3D micro/nano silicon structures
    A Ranella
    Institute of Electronic Structure and Laser, Foundation for Research and Technology Hellas, IESL FORTH, Heraklion, Greece
    Acta Biomater 6:2711-20. 2010
    ..The potential use of the patterned Si substrates as model scaffolds for the systematic exploration of the role of 3D micro/nano morphology and/or surface energy on cell adhesion and growth is envisaged...
  100. pmc Greater osteoblast proliferation on anodized nanotubular titanium upon electrical stimulation
    Batur Ercan
    Division of Engineering, Brown University, Providence, RI 02912, USA
    Int J Nanomedicine 3:477-85. 2008
    ..Thus, results of this study suggest that coupling the positive influences of electrical stimulation and nanotubular features on anodized titanium may improve osteoblast responses necessary for enhanced orthopedic implant efficacy...
  101. ncbi Electrospinning of nano/micro scale poly(L-lactic acid) aligned fibers and their potential in neural tissue engineering
    F Yang
    Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576
    Biomaterials 26:2603-10. 2005
    ..Based on the experimental results, the aligned nanofibrous PLLA scaffold could be used as a potential cell carrier in neural tissue engineering...

Research Grants65

  1. Human Pluripotent Stem Cell Differentiation with Defined O2 & Protein Engagement
    ROBERT SAMUEL LANGER; Fiscal Year: 2010
    ..In particular, high-throughput approaches will be used to develop culture materials with optimized surface properties incorporating defined extracellular matrix (ECM) components that allow for accurate control of oxygen ..
  2. Regulatory Mechanisms Controlling Expression of P. gingivalis Surface Structures
    MARY ELLEN DAVEY; Fiscal Year: 2013
    ..the regulatory mechanisms and signals that control the expression of genes involved in modifying the surface properties of P...
  3. Hazard Assessment and Risk Estimation of Inhaled Nanomaterials Exposure
    Gunter Oberdorster; Fiscal Year: 2010
    ..in the lungs through their oxidative stress-inducing potential that is related to their reactive surface properties and that the ensuing pulmonary inflammatory response enhances translocation to and effects in secondary ..
  4. Combinatorial Metal Oxide Substrates to Enhance Osteogenic Stem Cell Functions
    Jaime E Ramírez-Vick; Fiscal Year: 2012
    ..This approach will provide substrates with a range of subtle changes in surface properties and composition...
  5. Chaperone Assisted Crystallography
    Anthony A Kossiakoff; Fiscal Year: 2012
    ..of Fab-binding proteins that can be engineered to introduce anomalous atom types for MAD phasing and alter surface properties, as well as to induce lattice formation...
  6. Array development of anti-inflammatory peptoid-graft polymers for islet delivery
    Matthew Webber; Fiscal Year: 2013
    ..response through immunoisolation of encapsulated islets or by coating islets with materials to change surface properties. Here, we seek to develop new peptidomimetic materials for use in coating/encapsulating islets that not only ..
  7. Rapid Prototyping Method and Design Library for Universal POC Application
    VINCENT JEN JR GAU; Fiscal Year: 2010
    ..The wide variety of biocompatible surface properties of commercially available polymer/plastics provides a critical competitive advantage over conventional ..
  8. Structural Analysis of NAT Acetylation, Substrate Specificity and Polymorphisms
    Kylie J Walters; Fiscal Year: 2010
    ..3) Define how acetylation affects NAT structure and surface properties. The successful outcome of this research could aid in the prevention of bladder cancer and lead to new ..
  9. Interactions of engineered nanomaterials with lung alveolar epithelium
    EDWARD DAVID CRANDALL; Fiscal Year: 2010
    ..e., alveolar epithelium) in order to help understand possible injury from inhaled fullerenes with defined surface properties (e.g., charge and hydrophobicity). With this knowledge, improved nanomedical and biological applications (e...
  10. A Nanofibrous Bioactive Hemodialysis Access Graft
    SAIF G PATHAN; Fiscal Year: 2010
    ..electrospinning conditions for the nanofibrous BioAccess graft, 2) characterize physical, chemical and surface properties of the graft, 3) evaluate release pharmacokinetics of rHir, Moxifloxacin and Paclitaxel from the BioAccess ..
  11. A Nanofibrous Bioactive Hemodialysis Access Graft
    SAIF G PATHAN; Fiscal Year: 2013
    ..Phase II are to: 1) electrospin BioAccess grafts for implantation studies, qualify physical, chemical and surface properties of BioAccess grafts, 3) confirm biologic properties of BioAccess graft using established assays employed in ..
  12. Modulation of Qdot nanoparticle toxicity by glutathione in GCL transgenic mice
    TERRANCE JAMES KAVANAGH; Fiscal Year: 2010
    ..We hypothesize that the colloidal stability and nanomaterial surface properties such as surface ligands and functional groups will affect in vitro and in vivo behavior and toxicity of QDs...
  13. Development of a Surgical and Transcatheter Polymeric Heart Valve
    JACK CABELL GRIFFIS; Fiscal Year: 2012
    ..materials for heart valves for their tunable mechanical properties (for improved durability), tunable surface properties (for reduced calcification), and the ability to program hemocompatibility (for non-thrombogenecity)...
  14. Innovative Biofabrication of 3D Nano-Biocomposites for Repair of Osteochondral De
    LAURIE O'ROURKE; Fiscal Year: 2012
    ..which we can manufacture bacterial cellulose nano-biomaterial with spatially controlled architecture and surface properties. PUBLIC HEALTH RELEVANCE: Reconstruction of orthopedic defects that arise from trauma, disease, age, or ..
  15. Engineering of Proteins for Crystallography
    Adam Godzik; Fiscal Year: 2013
    ..we will investigate how surface entropy reduction affects protein solubility and stability, and how protein surface properties impact on the quality of heteronuclear NMR spectra...
  16. Development of LOS-Modified Nanoparticles for Improved Airway Epithelial Uptake
    Jennifer Fiegel; Fiscal Year: 2013
    ..conditions, and 2) determining the biochemical mechanism(s) responsible for modification of nanoparticle surface properties in respiratory mucus...
  17. Nanofluidic Devices for Studying Assembly of Single Virus Particles
    Stephen C Jacobson; Fiscal Year: 2013
    ..influenced depends strongly on the dimensions and geometries of the nanoscale conduits, applied waveforms, surface properties of the conduit, and composition of the transport medium, and particle shape and composition...
  18. Sytems Analysis of Nanoparticle Biocompatibility
    Brian D Thrall; Fiscal Year: 2011
    ..structure activity relationship (QSAR) approach to investigate the specific physical and chemical surface properties that influence nanoparticle biocompatibility...
  19. Engineered Organic Particles of Controlled Size, Shape and Surface Chemistry for
    Joseph M DeSimone; Fiscal Year: 2012
    ..able to fabricate nanoparticles with precise control over the particle size, shape, composition, cargo and surface properties to create truly engineered drug therapies that can be used to overcome the obstacles facing researchers and ..
  20. Novel Materials and Methods for Separations of Glycopeptides and Glycans
    Barry E Boyes; Fiscal Year: 2011
    ..be synthesized and tested for HILIC operation, as well as to establish the fundamental relationships between surface properties, particle characteristics, and utility for glycan and glycopeptides separations...
  21. Noninvasive Monitoring of Tissue-engineered Constructs by US Elasticity Imaging
    Kang Kim; Fiscal Year: 2012
    ..but with appropriate mechanical and degradation properties and (2) the scaffold must have the right surface properties to provide favorable conditions for cells to attach differentiate and lay down ECM...
  22. Enhanced radiation therapy with nanoscale frequency modulators
    Ming Su; Fiscal Year: 2012
    ..can cause chemical reactions of photoactive molecules immobilized on nanoparticles, and change the surface properties of nanoparticles so that nanoparticles can penetrate cellular and nuclear membranes;subsequent x- ray ..
  23. Apoptosis Inducing to Enhance Tumor Targeting
    Ze Lu; Fiscal Year: 2012
    ..In addition, the particle size and surface properties were selected to enhance the particle retention in the peritoneal cavity and the particle localization on ..
  24. VAPOR GROWN CARBON FIBERS FOR BIOMEDICAL APPLICATIONS
    THOMAS APPLE; Fiscal Year: 1993
    ..tailor or "fine-tune" the electrical and thermal conductivity, the tensile strength and the modulus and the surface properties through various doping, coating and annealing procedures to allow for their application in prosthesis and as ..
  25. Cell-and Nucleus-Permeable Luminescent Gold Nanoparticles
    Jie Zheng; Fiscal Year: 2010
    ..We propose to develop a library of luminescent gold nanoprobes with different surface properties, so that we can uncover the underlying principles that govern cell and nuclear permeability of gold ..
  26. Neural Representation of Features in the Human Visual Cortex
    Frank Tong; Fiscal Year: 2011
    ..activity in early human visual areas corresponds with visual feature perception across changes in the surface properties of the stimulus...
  27. Camptothecin-Containing Nanoparticles: Control Over Particle Size, Biodistributio
    Jianjun Cheng; Fiscal Year: 2012
    ..Numerous studies suggested that the size and the surface properties of NPs can have direct correlation with their biodistribution in vivo...
  28. Engineering Functional Salivary Glands Using Micropatterned Scaffolds
    Melinda Larsen; Fiscal Year: 2013
    ..Aim 3: Optimize nanofiber surface properties to enhance salivary gland acinar cell function...
  29. Investigation into Mechanisms NLRP3 Activation by Nickel Associated Multi-Walled
    TERI ALYN GIRTSMAN; Fiscal Year: 2013
    ..However, a mechanistic predictive model based on physical and surface properties of ENM has not been established to aid in protecting human health...
  30. The development of object representation in infancy
    Lisa M Oakes; Fiscal Year: 2010
    ..object manipulation, we will (a) examine the role of motor development in infants'representation of the surface properties of objects (Experiments 1-4), and (b) investigate the role of developing memory and attention skills on the ..
  31. ELECTROSTATIC SURFACE OPTIMIZATION FOR OSSEOINTEGRATION
    Michele Marcolongo; Fiscal Year: 2000
    ..Once the specific surface properties which encourage osteoblast attachment are determined, it would then be possible to engineer the surface of ..
  32. In Silico and in Vitro Investigation of Non-Conserved Interaction Characteristics
    David A Liberles; Fiscal Year: 2013
    ..Signals of evolutionary adaptation will be sought in the protein surface properties and the encoding genes, in context of the 3D-structure of the target proteins...
  33. CARBONATOAPATITE FORMATION IN ENAMEL MINERALIZATION
    Takaaki Aoba; Fiscal Year: 1993
    ..of chemical and physical properties will be used to study the effects of mineral composition and crystal-surface properties on the adsorption of enamel proteins and inhibitory activity of the adsorbed proteins on apatite crystal ..
  34. Processing and Characterization of Coatings for Polymeric Implants
    Afsaneh Rabiei; Fiscal Year: 2013
    ..Confirmation that we can successfully modify the surface properties of PEEK has given us confidence that we can adapt this approach to other polymers, including ultra-high ..
  35. Mucus Penetrating Nanoparticles for Vaginal Drug Delivery
    Justin Hanes; Fiscal Year: 2009
    ..In Aim 1, we will fully characterize particle size and surface properties, and use particle tracking to observe diffusional transport rates of mucus-penetrating and conventional ..
  36. Novel Materials and Methods for Separations of Glycopeptides and Glycans
    Barry E Boyes; Fiscal Year: 2013
    ..be synthesized and tested for HILIC operation, as well as to establish the fundamental relationships between surface properties, particle characteristics, and utility for glycan and glycopeptides separations...
  37. A Translational Approach Towards Ligament Regeneration
    Cato T Laurencin; Fiscal Year: 2013
    ..with surface modification techniques will be used to create scaffolds with optimized pore structure and surface properties to facilitate cell adhesion, migration, proliferation, and tissue in- growth, as well as mechanical ..
  38. Assess structure and microbial interactions of clay mineral antibacterial agent
    Lynda Williams; Fiscal Year: 2007
    ..of the clay mineral especially with regard to mycobacteria, (2) determine if the crystal structure and surface properties of the clay mineral are responsible for its antibacterial effects, (3) identify the specific, toxic ..
  39. The representation of surface appearance in visual cortex
    Jonathan A Winawer; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The broad goals of this proposal are to increase understanding of how surface properties are represented by the visual system...
  40. New biomaterials for ocular surface reconstruction.
    Mark I Rosenblatt; Fiscal Year: 2010
    ..We propose to design bioengineered tissues composed of with surface properties that will facilitate repair of the eye.
  41. SURFACE ENGINEERING IN CONTACT ACTIVATION OF COAGULATION
    Christopher A Siedlecki; Fiscal Year: 2013
    ..with measured adsorption properties of blood proteins and fails to account for relationships among activator surface properties, production of enzyme intermediates, and time to plasma coagulation in vitro...
  42. GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AG
    Yasuko Rikihisa; Fiscal Year: 2004
    ..surface proteins may provide an instructive model for studying adaptive genetic strategies, and fundamental surface properties, of several ehrlichial species contributing to human and animal diseases...
  43. Sensor for Paralytic Shellfish Poisons
    ROBERT GAWLEY; Fiscal Year: 2006
    ..2. Self-assembly and covalent attachment of the sensors to glass slides and evaluation of the surface properties and coating. 3...
  44. Trophoblast Selectins and Their Uterine Mucin Ligands
    Susan Fisher; Fiscal Year: 2006
    ..In essence, they assume many of the cell surface properties of endothelial cells...
  45. DIRECT OBSERVATION OF INTERFACIAL PROCESS
    Vladimir Hlady; Fiscal Year: 2001
    ..protein-biomaterial surface adsorption and to relate it to the two-dimensional variation of biomaterial's surface properties, such as surface energy and elasticity...
  46. DIRECT OBSERVATION OF INTERFACIAL PROCESS
    Vladimir Hlady; Fiscal Year: 2003
    ..protein-biomaterial surface adsorption and to relate it to the two-dimensional variation of biomaterial's surface properties, such as surface energy and elasticity...
  47. VASCULAR ENDOTHELIUM AND FLUID SHEAR STRESS IN VITRO
    C Dewey; Fiscal Year: 1990
    ..as defined by cell surface-selective patterns of integral- and membrane-associated proteins; (ii) functional surface properties, as characterized by tissue factor procoagulant activity and surface adhesiveness for platelets; and (iii) ..
  48. Detection of Bacteria using Nanoparticle-Polymer Sensors
    VINCENT ROTELLO; Fiscal Year: 2009
    ..uses multivalent interactions between polymers and nanoparticles, coupled with the ability to engineer the surface properties of nanoparticles to provide controlled interactions with biological systems...
  49. Cluster Ion Sources for ToF-SIMS
    David G Castner; Fiscal Year: 2012
    ..The proposed cluster ion beam sources will provide new information about the surface properties of biomedical devices, as well as the biomolecules and cells interacting with those devises, that is needed ..
  50. CHARACTERIZATION OF MICROBIAL LECTINS
    Patricia Murray; Fiscal Year: 1992
    ..Although it is recognized that the surface properties of bacteria may ultimately determine the outcome of host-parasite interactions, the precise nature of the ..
  51. Cluster Ion Source for ESCA Instrument
    David G Castner; Fiscal Year: 2010
    ..The proposed cluster ion beam source will provide new information about the surface properties of biomedical devices that is needed to achieve this objective.
  52. POLYMERIC MICELLAR CONTRAST AGENTS FOR CT ANGIOGRAPHY
    John Babich; Fiscal Year: 2000
    ..to reduce both the iodine load to the patient and the time necessary to perform the examination by modifying surface properties of the micelle vesicles...
  53. 3 to15 Covalent Gold for High Resolution Electron Microscopy
    VISHWAS JOSHI; Fiscal Year: 2009
    ..domain for stabilizing the gold nanoparticles, and hydrophilic surface groups that provide a wide choice of surface properties and conjugation reactions...
  54. Novel-Non-Viral Delivery of IFN Gene to Cancer Cells
    NATHALIE BELLOCQ; Fiscal Year: 2004
    ..The adamantane component self-assembles with the particles to modify the surface properties, thereby adapting the particles to be more suitable for systemic delivery...
  55. Biological fate and biocompatibility of dendritic and silica-based nanoconstructs
    Hamid Ghandehari; Fiscal Year: 2010
    ..These nanoconstructs can be fabricated with discrete, well-defined monodisperse size, shape and surface properties. However little is known about the interactions of these particles with mammalian systems including their ..
  56. Structure-Function of Borrelia Surface Lipoproteins
    WOLFRAM ZUECKERT; Fiscal Year: 2005
    ..variable and membrane-distal loops (i) form the Vsp-specific antibody epitopes, and (ii) also confer the surface properties involved in tissue localization...
  57. FOREIGN BODY REACTION AND DEVICE CENTERED INFECTION
    Liping Tang; Fiscal Year: 2002
    ..how adsorbed fibrinogen actually enhances the persistence of implant-associated bacteria and how particular surface properties influence both foreign body reactions and device-centered infection...
  58. FOREIGN BODY REACTION AND DEVICE CENTERED INFECTION
    Liping Tang; Fiscal Year: 2001
    ..how adsorbed fibrinogen actually enhances the persistence of implant-associated bacteria and how particular surface properties influence both foreign body reactions and device-centered infection...
  59. GENETIC RECOMBINATION IN MYCOPLASMAS
    Kevin Dybvig; Fiscal Year: 1993
    ..Recent studies have shown that the surface properties of mycoplasmas vary at a high frequency of about 10-3 per cell per generation...
  60. DYSREGULATION OF CETP AND LPL IN THE DIABETIC CYNOMOLGUS
    John Bagdade; Fiscal Year: 1993
    ..that CIT leads to peripheral hyperinsulinism and stimulation of lipoprotein lipase (LpL) which alters the surface properties of larger VLDL and enhances their affinity for cholesterol ester transfer protein (CETP)...
  61. PHOSPHOLIPIDS AND ULCER PROTECTION
    Lenard Lichtenberger; Fiscal Year: 2002
    ..made by our laboratory: 1) that the mucosal surface of the GI tract has hydrophobic (acid-resistant) surface properties due to the presence of an extracellular lining of zwitterionic phospholipids; 2) that NSAIDs form a chemical ..
  62. Germination of Bacillus anthracis Spores in Macrophages
    Daoguo Zhou; Fiscal Year: 2004
    ..spores from pathogenic isolates and that germination requires specific receptors and/or specific spore surface properties. In order to test this hypothesis, we propose two approaches: 1) initially direct or limit spores to ..
  63. SENTINEL LYMPH NODE STAGING WITH MAGNETIC NANOPARTICLES
    JEROME LEWIS; Fiscal Year: 1999
    ..2) Determine the effect of nanoparticle surface properties on nodal nanoparticle uptake rates...
  64. Self Assembly Methods for Surface Properties for stents
    Jennifer Lalli; Fiscal Year: 2004
    ..These patented nanotechnology-based processes would allow the spatial grading of mechanical and other properties at the molecular level, specifically as required by our working hypothesis, to mitigate turbulent flow-induced restenosis. ..
  65. High and Low Frequency Scanning Acoustic Microscopes
    Paulette Spencer; Fiscal Year: 2002
    ..of SAM is the ability to investigate the properties of internal and subsurface structures in addition to the surface properties of most materials, including those that are optically opaque...