lipid peroxidation

Summary

Summary: Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor.

Top Publications

  1. ncbi Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers
    T C Dinis
    Laboratorio de Bioquimica, Faculdade de Farmacia, Universidade de Coimbra, Portugal
    Arch Biochem Biophys 315:161-9. 1994
  2. ncbi Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model
    Lutz W D Weber
    Institute of Toxicology, GSF National Research Center for Environment and Health, Munich, P O Box 1129, D 85758 Neuherberg FRG
    Crit Rev Toxicol 33:105-36. 2003
  3. ncbi Lipid peroxidation and neurodegenerative disease
    Tanea T Reed
    Department of Chemistry, Eastern Kentucky University, Richmond, KY 40475, USA
    Free Radic Biol Med 51:1302-19. 2011
  4. ncbi Free radicals and antioxidants in human health: current status and future prospects
    T P A Devasagayam
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085
    J Assoc Physicians India 52:794-804. 2004
  5. ncbi Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism
    Petr Jezek
    Department of Membrane Transport Biophysics, No 75, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, CZ 14220 Prague, Czech Republic
    Int J Biochem Cell Biol 37:2478-503. 2005
  6. pmc Resveratrol protects rats from Aβ-induced neurotoxicity by the reduction of iNOS expression and lipid peroxidation
    Tai Chun Huang
    Department of Biochemical Science and Biotechnology, National Chia Yi University, Chia Yi, Taiwan
    PLoS ONE 6:e29102. 2011
  7. ncbi α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome
    Mototada Shichiri
    Health Research Institute, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
    Free Radic Biol Med 50:1801-11. 2011
  8. ncbi Life and death: metabolic rate, membrane composition, and life span of animals
    A J Hulbert
    Metabolic Research Centre, Institute for Conservation Biology, School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, Australia
    Physiol Rev 87:1175-213. 2007
  9. ncbi Lipid hydroperoxide generation, turnover, and effector action in biological systems
    A W Girotti
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee 53226 4801, USA
    J Lipid Res 39:1529-42. 1998
  10. ncbi Protective effects of vitamin c against cisplatin-induced nephrotoxicity and lipid peroxidation in adult rats: a dose-dependent study
    L M Antunes
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av. Cafe s/n, Ribeirao Preto, Sao Paulo, 14040-903, Brasil
    Pharmacol Res 41:405-11. 2000

Research Grants

Detail Information

Publications283 found, 100 shown here

  1. ncbi Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers
    T C Dinis
    Laboratorio de Bioquimica, Faculdade de Farmacia, Universidade de Coimbra, Portugal
    Arch Biochem Biophys 315:161-9. 1994
    ..The action of the phenolic compounds acetaminophen, salicylate, and 5-aminosalicylate (5-ASA) as inhibitors of lipid peroxidation was studied under conditions suitable for establishing their antioxidant potencies...
  2. ncbi Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model
    Lutz W D Weber
    Institute of Toxicology, GSF National Research Center for Environment and Health, Munich, P O Box 1129, D 85758 Neuherberg FRG
    Crit Rev Toxicol 33:105-36. 2003
    ..CCl3OO* initiates the chain reaction of lipid peroxidation, which attacks and destroys polyunsaturated fatty acids, in particular those associated with phospholipids...
  3. ncbi Lipid peroxidation and neurodegenerative disease
    Tanea T Reed
    Department of Chemistry, Eastern Kentucky University, Richmond, KY 40475, USA
    Free Radic Biol Med 51:1302-19. 2011
    b>Lipid peroxidation is a complex process involving the interaction of oxygen-derived free radicals with polyunsaturated fatty acids, resulting in a variety of highly reactive electrophilic aldehydes...
  4. ncbi Free radicals and antioxidants in human health: current status and future prospects
    T P A Devasagayam
    Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085
    J Assoc Physicians India 52:794-804. 2004
    ..Lipids are highly prone to free radical damage resulting in lipid peroxidation that can lead to adverse alterations. Free radical damage to protein can result in loss of enzyme activity...
  5. ncbi Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism
    Petr Jezek
    Department of Membrane Transport Biophysics, No 75, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, CZ 14220 Prague, Czech Republic
    Int J Biochem Cell Biol 37:2478-503. 2005
    ....
  6. pmc Resveratrol protects rats from Aβ-induced neurotoxicity by the reduction of iNOS expression and lipid peroxidation
    Tai Chun Huang
    Department of Biochemical Science and Biotechnology, National Chia Yi University, Chia Yi, Taiwan
    PLoS ONE 6:e29102. 2011
    ..result in a significant impairment in spatial memory, a marked increase in the cellular level of iNOS and lipid peroxidation, and an apparent decrease in the expression of heme oxygenase-1 (HO-1)...
  7. ncbi α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome
    Mototada Shichiri
    Health Research Institute, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
    Free Radic Biol Med 50:1801-11. 2011
    ..Supplementation with α-tocopherol decreased levels of lipid peroxidation products in Ts65Dn mice...
  8. ncbi Life and death: metabolic rate, membrane composition, and life span of animals
    A J Hulbert
    Metabolic Research Centre, Institute for Conservation Biology, School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, Australia
    Physiol Rev 87:1175-213. 2007
    ..When combined with the fact that 1) the products of lipid peroxidation are powerful reactive molecular species, and 2) that fatty acids differ dramatically in their susceptibility ..
  9. ncbi Lipid hydroperoxide generation, turnover, and effector action in biological systems
    A W Girotti
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee 53226 4801, USA
    J Lipid Res 39:1529-42. 1998
    b>Lipid peroxidation is a well known example of oxidative damage in cell membranes, lipoproteins, and other lipid-containing structures...
  10. ncbi Protective effects of vitamin c against cisplatin-induced nephrotoxicity and lipid peroxidation in adult rats: a dose-dependent study
    L M Antunes
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av. Cafe s/n, Ribeirao Preto, Sao Paulo, 14040-903, Brasil
    Pharmacol Res 41:405-11. 2000
    ..using single doses of both compounds. Cisplatin administration induced lipid peroxidation which was accompanied by a decrease in renal glutathione level in animals killed 7 days after treatments...
  11. ncbi Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure
    Hyun Ju Kim
    Division of Nephrology and Hypertension, University of California, Irvine, California, USA
    Am J Physiol Renal Physiol 298:F662-71. 2010
    ..In confirmation of earlier studies, rats with chronic renal failure exhibited increased lipid peroxidation, glutathione depletion, NF-kappaB activation, mononuclear cell infiltration, and upregulation of monocyte ..
  12. ncbi Plasma total antioxidant capacity, lipid peroxidation, and erythrocyte antioxidant enzyme activities in patients with rheumatoid arthritis and osteoarthritis
    Sezgin Sarban
    Department of Orthopaedic Surgery, Harran University, Medical Faculty, 63200 Sanliurfa, Turkey
    Clin Biochem 38:981-6. 2005
    ..The aim of the present study was to investigate the total antioxidant capacity (TAC), levels of lipid peroxidation (LPO), and antioxidant enzyme activities in patients with rheumatoid arthritis (RA) and osteoarthritis (OA).
  13. pmc Increased oxidative stress in obesity and its impact on metabolic syndrome
    Shigetada Furukawa
    Department of Medicine and Pathophysiology, Graduate School of Medicine, Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Clin Invest 114:1752-61. 2004
    ....
  14. ncbi Disparate patterns of age-related changes in lipid peroxidation in long-lived naked mole-rats and shorter-lived mice
    Blazej Andziak
    Department of Biology, The City College of the City University of New York, New York, NY 10031, USA
    Aging Cell 5:525-32. 2006
    ..We compared age-related profiles of whole-organism lipid peroxidation (urinary isoprostanes) and liver lipid damage (malondialdehyde) in long living naked mole-rats [maximum ..
  15. ncbi A high-fat diet impairs neurogenesis: involvement of lipid peroxidation and brain-derived neurotrophic factor
    Hee Ra Park
    Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Longevity Life Science and Technology Institutes, Pusan National University, Geumjeong Gu, Busan 609 735, Republic of Korea
    Neurosci Lett 482:235-9. 2010
    ..MDA reduced the growth of NPCs, but BDNF treatment restored NPCs proliferation. The present data indicate that a HFD impairs hippocampal neurogenesis and NPCs proliferation through increased lipid peroxidation and decreased BDNF.
  16. pmc Proanthocyanidins produce significant attenuation of doxorubicin-induced mutagenicity via suppression of oxidative stress
    Sabry M Attia
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Oxid Med Cell Longev 3:404-13. 2010
    ..Prior administration of proanthocyanidins ahead of doxorubicin reduced the doxorubicin induced testicular lipid peroxidation and prevented the reduction in testicular non-protein sulfhydryl significantly...
  17. ncbi Pathological aspects of lipid peroxidation
    Anne Negre-Salvayre
    INSERM I2MR 858, IFR 150, Avenue J Poulhès, BP 84225, Toulouse, France
    Free Radic Res 44:1125-71. 2010
    b>Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases...
  18. pmc Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease
    D Allan Butterfield
    Department of Chemistry, Center of Membrane Sciences, Sanders Brown Center on Aging, University of Kentucky, Lexington KY 40506 0055, USA
    Biochim Biophys Acta 1801:924-9. 2010
    ..Increased levels of oxidative stress markers including the markers of lipid peroxidation such as acrolein, 4-hydroxy-2-trans-nonenal (HNE), malondialdehyde, etc. are found in brains of AD subjects...
  19. ncbi Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions
    Angel Catala
    Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas INIFTA CCT La Plata CONICET, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CC 16, Sucursal 4, 1900 La Plata, Argentina
    Chem Phys Lipids 157:1-11. 2009
    ..b>Lipid peroxidation, which leads to lipid hydroperoxide formation often, occurs in response to oxidative stress...
  20. ncbi Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease
    Tanea Reed
    Department of Chemistry, University of Kentucky, Lexington, KY 40506 0055, USA
    Neurobiol Dis 30:107-20. 2008
    ..Accumulated evidence indicates that lipid peroxidation is an early event during the evolution of the disease and occurs in patients with mild cognitive impairment (..
  21. ncbi Lipid peroxidation: physiological levels and dual biological effects
    Etsuo Niki
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
    Free Radic Biol Med 47:469-84. 2009
    b>Lipid peroxidation (LPO) has been shown to induce disturbance of membrane organization and functional loss and modification of proteins and DNA bases, and it has been implicated in the pathogenesis of various diseases...
  22. ncbi Oxidative stress & male infertility
    Kartikeya Makker
    Center for Reproductive Medicine, Glickman Urological and Kidney Institute and Obsterics Gynecology and Women s Health Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Indian J Med Res 129:357-67. 2009
    ..It also highlights the mechanism of production and the pathophysiology of ROS in relation to the male reproductive system and enumerate the benefits of incorporating antioxidants in clinical and experimental settings...
  23. ncbi Carbon tetrachloride-induced nephrotoxicity in rats: protective role of Digera muricata
    Muhammad R Khan
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad 4400, Pakistan
    J Ethnopharmacol 122:91-9. 2009
    ..reactive radicals has been implicated in carbon tetrachloride-induced nephrotoxicity, which are involved in lipid peroxidation, accumulation of dysfunctional proteins, leading to injuries in kidneys...
  24. ncbi Factors associated with oxidative stress in human populations
    Gladys Block
    Division of Health Policy and Management, School of Public Health, University of California, Berkeley, CA 94720, USA
    Am J Epidemiol 156:274-85. 2002
    ..This paper presents data on levels of two biomarkers of lipid peroxidation, malondialdehyde and F(2)-isoprostanes, in 298 healthy adults aged 19-78 years...
  25. ncbi High oxidative damage levels in the longest-living rodent, the naked mole-rat
    Blazej Andziak
    Department of Biology, City College of the City University of New York, New York, NY 10031, USA
    Aging Cell 5:463-71. 2006
    ..and a surprisingly more pro-oxidative cellular environment, manifested by 10-fold higher levels of in vivo lipid peroxidation. Furthermore, mole-rats exhibit greater levels of accrued oxidative damage to lipids (twofold), DNA (..
  26. ncbi Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action
    Mahmoud A Mansour
    Department of Pharmacology, Faculty of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    Cell Biochem Funct 20:143-51. 2002
    ..firstly, on the effects of oral administration of thymoquinone (TQ) on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase activity in hepatic, cardiac and kidney tissues of normal mice...
  27. ncbi Chemistry and biochemistry of lipid peroxidation products
    F Gueraud
    UMR1089 Xenobiotiques, INRA, Toulouse, France
    Free Radic Res 44:1098-124. 2010
    Oxidative stress and resulting lipid peroxidation is involved in various and numerous pathological states including inflammation, atherosclerosis, neurodegenerative diseases and cancer...
  28. ncbi Evaluation of oxidative stress in autism: defective antioxidant enzymes and increased lipid peroxidation
    Nagwa A Meguid
    Department of Research on Children with Special Needs, National Research Center, Tahrir St, Cairo, Egypt
    Biol Trace Elem Res 143:58-65. 2011
    ..dismutase (SOD) and glutathione peroxidase (GSH-Px), and levels of malondialdehyde (MDA), a marker of lipid peroxidation, in Egyptian autistic children...
  29. ncbi Combination effects of enalapril and losartan on lipid peroxidation in the kidneys of KK-Ay/Ta mice
    Takahiko Yamazaki
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Nephron Exp Nephrol 113:e66-76. 2009
    Adenosine monophosphate activated protein kinase (AMPK) has a protective effect on lipid peroxidation. Adiponectin and AMPK might have a role in the pathogenesis of diabetic nephropathy...
  30. pmc Overview of lipid peroxidation products and hepatic protein modification in alcoholic liver disease
    Rebecca L Smathers
    Molecular Toxicology Program, Department of Pharmaceutical Sciences, University of Colorado Denver, USA
    Chem Biol Interact 192:107-12. 2011
    ..Studies were initiated to identify hepatic proteins that are targets of 4-HNE modification and determine their relationship with progression of the early stages of ALD...
  31. ncbi The lipid peroxidation by-product 4-hydroxy-2-nonenal (4-HNE) induces insulin resistance in skeletal muscle through both carbonyl and oxidative stress
    Nicolas J Pillon
    Universite de Lyon, F 69622 Lyon, France
    Endocrinology 153:2099-111. 2012
    ..Under conditions of oxidative stress, lipid peroxidation of ω6-polyunsaturated fatty acids leads to the production of 4-hydroxy-2-nonenal (4-HNE)...
  32. ncbi Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles
    Renping Hu
    Medical College, Soochow University, Suzhou, China
    J Hazard Mater 191:32-40. 2011
    ..These findings suggest that TiO(2) NP-induced apoptosis in the mouse hippocampus may result from an intrinsic pathway, and workers and consumers should take great caution when handling nanomaterials...
  33. ncbi Selective toxicity of ZnO nanoparticles toward Gram-positive bacteria and cancer cells by apoptosis through lipid peroxidation
    Mariappan Premanathan
    Department of Biotechnology, Mepco Schlenk Engineering College, Sivakasi, Tamil Nadu, India
    Nanomedicine 7:184-92. 2011
    ..The nanoparticles enhanced ultrasound-induced lipid peroxidation in the liposomal membrane...
  34. ncbi Antioxidant and hepatoprotective effect of Acanthus ilicifolius
    B H Babu
    Amala Cancer Research Centre, Amala Nagar, 680 553, Thrissur, India
    Fitoterapia 72:272-7. 2001
    ..These results were comparable with those obtained with curcumin (100 mg/kg, p.o.)...
  35. pmc Lipid peroxidation and total antioxidant capacity in vitreous, aqueous humor, and blood samples from patients with diabetic retinopathy
    Raffaele Mancino
    Ophthalmology Unit, Department of Biopathology, Tor Vergata University of Rome, Rome, Italy
    Mol Vis 17:1298-304. 2011
    ..To evaluate levels of malondialdehyde and the total antioxidant capacity (TAC) in the blood, aqueous humor, and vitreous bodies of diabetic and nondiabetic patients. We also measured the blood energy charge potential (ECP)...
  36. pmc Role of lipid peroxidation and PPAR-δ in amplifying glucose-stimulated insulin secretion
    Guy Cohen
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Institute for Drug Research, Hebrew University, Jerusalem, Israel
    Diabetes 60:2830-42. 2011
    ..We aimed at identifying PUFA-derived mediators and their cellular targets that are involved in the amplification of insulin release from β-cells preexposed to high glucose levels...
  37. ncbi F2-isoprostanes as markers of oxidative stress in vivo: an overview
    Ginger L Milne
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    Biomarkers 10:S10-23. 2005
    ..studies carried out over the past decade have shown that these compounds are extremely accurate measures of lipid peroxidation and have illuminated the role of oxidant injury in a number of human diseases including atherosclerosis, ..
  38. ncbi Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress
    D Allan Butterfield
    Department of Chemistry, Center of Membrane Sciences, and Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506 0055, USA
    Free Radic Biol Med 32:1050-60. 2002
    ..review summarizes current knowledge on phospholipid peroxidation and protein oxidation in AD brain, one potential cause of this oxidative stress, and consequences of A(beta)-induced lipid peroxidation and protein oxidation in AD brain.
  39. pmc The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy
    T Zhou
    Department of Biochemistry, Zhongshan Medical School, Sun Yat Sen University, Guangzhou, China
    Diabetologia 54:459-68. 2011
    ..Here we investigated the causative role of oxidative stress in retinal WNT pathway activation in an experimental model of diabetes...
  40. ncbi Role of oxidative modifications in atherosclerosis
    Roland Stocker
    Centre for Vascular Research, University of New South Wales, Sydney, New South Wales, Australia
    Physiol Rev 84:1381-478. 2004
    ..To address this issue, we have proposed an "oxidative response to inflammation" model as a means of reconciling the response-to-injury and oxidative modification hypotheses of atherosclerosis...
  41. ncbi Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia
    Jianguo Li
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Appl Physiol 102:557-63. 2007
    ..The goal of the study was to determine if CIH causes lipid peroxidation and dyslipidemia in the absence of obesity and whether the degrees of dyslipidemia and lipid peroxidation ..
  42. ncbi Lipid peroxidation and antioxidant enzyme activities in vascular and Alzheimer dementias
    Angela Casado
    Departamento de Fisiopatología Celular y Molecular, Centro de Investigaciones Biologicas CSIC, Ramiro de Maeztu, 9, Madrid 28040, Spain
    Neurochem Res 33:450-8. 2008
    ..001). We conclude that oxidative stress plays an important role in the brain damage for both AD and VD, being observed higher levels of oxidative stress for AD that for VD...
  43. ncbi Effect of dietary docosahexaenoic acid connecting phospholipids on the lipid peroxidation of the brain in mice
    Seiichi Hiratsuka
    Shizuoka Prefectural Research Institute of Fishery, Yaizu, Shizuoka, Japan
    J Nutr Sci Vitaminol (Tokyo) 54:501-6. 2008
    The effect of dietary docosahexaenoic acid (DHA, C22:6n-3) with two lipid types on lipid peroxidation of the brain was investigated in streptozotocin (STZ)-induced diabetic mice...
  44. ncbi Alterations in brain antioxidant status, protein oxidation and lipid peroxidation in response to different stress models
    Emel Sahin
    Department of Biochemistry, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey
    Behav Brain Res 155:241-8. 2004
    ..glutathione peroxidase (Se-GSH-Px) activities, and reduced glutathione (GSH), protein carbonyl (PC) and lipid peroxidation marker (conjugated diene (CD) and thiobarbituric acid-reactive substances (TBARS)) levels in brain of rats, ..
  45. ncbi Protective effects of Digera muricata (L.) Mart. on testis against oxidative stress of carbon tetrachloride in rat
    Muhammad Rashid Khan
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
    Food Chem Toxicol 47:1393-9. 2009
    ..muricata treatment augments the antioxidants defense mechanism against carbon tetrachloride induced toxicity and provides evidence that it may have a therapeutic role in free radical mediated diseases...
  46. ncbi Early anti-inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in rats
    Feng Bao
    Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada
    J Neurochem 88:1335-44. 2004
    ..estimating macrophage infiltration), myeloperoxidase activity (MPO, approximating neutrophil infiltration), lipid peroxidation, inducible nitric oxide synthase (iNOS) and nitrotyrosine (indicating protein nitration) expression in the ..
  47. ncbi Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: relationship to decreased fat and lipid peroxidation
    Anshu Mittal
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Carcinogenesis 24:1379-88. 2003
    ..revealed that treatment of GSP in vivo and in vitro systems significantly inhibited UVB- or Fe3+-induced lipid peroxidation by 57-66% (P<0.01) and 41-77% (P< 0.05-0...
  48. ncbi A new insight into resveratrol as an atheroprotective compound: inhibition of lipid peroxidation and enhancement of cholesterol efflux
    Hicham Berrougui
    Research Center on Aging, Sherbrooke, QC, Canada
    Atherosclerosis 207:420-7. 2009
    ..We measured the formation of conjugated dienes and the rate of lipid peroxidation, and observed that resveratrol inhibited copper- and irradiation-induced LDL and HDL oxidation as observed ..
  49. ncbi Lipid peroxidation and antioxidative enzyme activities in childhood epilepsy
    Dilsad Turkdogan
    Institute of Neurological Sciences, Marmara University, Istanbul, Turkey
    J Child Neurol 17:673-6. 2002
    This study aimed to investigate the relationship among lipid peroxidation, subsequent activation of scavenger enzymes (superoxide dismutase and glutathione peroxidase), and the presence of structural abnormality in 52 epileptic children ..
  50. ncbi In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases
    Shuichi Seki
    Third Department of Internal Medicine, Osaka City University Medical School, 1 4 3, Asahimachi, Abenoku, Osaka 545 8585, Japan
    J Hepatol 37:56-62. 2002
    ..Although oxidative stress is an important candidate in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), the localization and pathological significance of oxidative stress-induced cellular damage in NAFLD remains unclear...
  51. ncbi Acidic pH amplifies iron-mediated lipid peroxidation in cells
    F Q Schafer
    Free Radical Research Institute and ESR Facility, The University of Iowa, Iowa City, IA 52242 1101, USA
    Free Radic Biol Med 28:1175-81. 2000
    The goal of our study was to investigate the mechanism by which changes in extracellular pH influence lipid peroxidation processes...
  52. ncbi Oxidative stress in chronic hepatitis C: not just a feature of late stage disease
    Sanjiv K Jain
    The Liver Unit, Manchester Royal Infirmary, Manchester, UK
    J Hepatol 36:805-11. 2002
    ..Chronic hepatitis C infection is a major world-wide problem, frequently progressing to cirrhosis, liver failure or hepatoma. The pathological mechanisms of disease progression are unclear but oxidant stress may play a role...
  53. ncbi Plasma total antioxidant capacity in hemodialyzed patients and its relationships to other biomarkers of oxidative stress and lipid peroxidation
    Gianmario Gerardi
    III Servizio di Analisi Chimico Cliniche Laboratorio di Biotecnologie, Spedali Civili di Brescia, Italy
    Clin Chem Lab Med 40:104-10. 2002
    ..Plasma lipid peroxidation was assessed by determining the peroxidation products malonaldehyde and 4-hydroxynonenal (MDA-4HNE) as well ..
  54. ncbi Products of the isoprostane pathway: unique bioactive compounds and markers of lipid peroxidation
    L Jackson Roberts
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232 6602, USA
    Cell Mol Life Sci 59:808-20. 2002
    ..to lysine residues on proteins and induce cross-links at rates that far exceed other aldehyde products of lipid peroxidation. Isoprostane-like compounds (neuroprostanes) and isoketal-like compounds (neuroketals) are formed from ..
  55. ncbi Green tea supplementation affects body weight, lipids, and lipid peroxidation in obese subjects with metabolic syndrome
    Arpita Basu
    Nutritional Sciences, Human Environmental Sciences, Oklahoma State University, Stillwater, Oklahoma, USA
    J Am Coll Nutr 29:31-40. 2010
    ..To compare the effects of supplementation of green tea beverage or green tea extracts with controls on body weight, glucose and lipid profile, biomarkers of oxidative stress, and safety parameters in obese subjects with metabolic syndrome...
  56. ncbi Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair
    Helmut Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Langenbecks Arch Surg 391:499-510. 2006
    ..Chronic inflammatory processes induce oxidative/nitrosative stress and lipid peroxidation (LPO), thereby generating excess reactive oxygen species (ROS), reactive nitrogen species (RNS), and DNA-..
  57. ncbi Damage to the structure of erythrocyte plasma membranes in patients with type-2 hypercholesterolemia
    Maria Koter
    Department of Environment Pollution Biophysics, University of Lodz, 12 16 Banacha St, 90 347, Lodz, Poland
    Int J Biochem Cell Biol 36:205-15. 2004
    ..The study involved 60 hypercholesterolemic patients and 30 healthy individuals as the control group...
  58. pmc Phospholipase A(2), reactive oxygen species, and lipid peroxidation in CNS pathologies
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, Cardiovascular Research Center, Neuroscience Training Program, University of Wisconsin, Madison, WI, USA
    BMB Rep 41:560-7. 2008
    ..Dissecting the contribution of PLA(2) to lipid peroxidation in CNS injury and disorders is a challenging proposition due to the multiple forms of PLA(2), the diverse ..
  59. ncbi Measurement of lipid peroxidation
    K Moore
    Department of Medicine, Royal Free Hospital School of Medicine, London, UK
    Free Radic Res 28:659-71. 1998
    b>Lipid peroxidation results in the formation of conjugated dienes, lipid hydroperoxides and degradation products such as alkanes, aldehydes and isoprostanes...
  60. ncbi Plasma lipid peroxidation and antioxidant levels in patients with rheumatoid arthritis
    Ayhan Kamanli
    Department of Physical Medicine and Rehabilitation, Medical Faculty, Firat University, Elazig, Turkey
    Cell Biochem Funct 22:53-7. 2004
    ..of vitamin E, beta-carotene, activities of glutathione peroxidase (GSH-Px) and catalase, levels of lipid peroxidation (MDA) and reduced glutathione (GSH) in 36 patients with rheumatoid arthritis (RA) and 22 healthy age-matched ..
  61. ncbi Edaravone prevents kainic acid-induced neuronal death
    Ryohei Miyamoto
    Department of Pediatrics, Osaka Medical College, Japan
    Brain Res 1209:85-91. 2008
    ..significantly lessened the KA-induced increase of HNE, Ed may exert its neuroprotective effect by inhibiting lipid peroxidation. However, post-treatment with Ed prevented neuronal cell loss, while HNE and glutathione levels did not ..
  62. ncbi Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis
    D Pratico
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 21:4183-7. 2001
    Oxidative stress is a key feature in the Alzheimer's disease (AD) brain and manifests as lipid peroxidation (LPO). Isoprostanes (iPs) are specific and sensitive markers of in vivo LPO...
  63. ncbi Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia
    Rao Muralikrishna Adibhatla
    Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792 3232, USA
    Free Radic Biol Med 40:376-87. 2006
    ..of PLA2 in cerebral ischemia has been shown while other studies have separately demonstrated increased lipid peroxidation. To the best of our knowledge no study has directly shown the role of PLA2 in lipid peroxidation in cerebral ..
  64. ncbi Differential effects of carotenoids on lipid peroxidation due to membrane interactions: X-ray diffraction analysis
    Hyesun P McNulty
    Elucida Research, 100 Cummings Center, Suite 135L, P O Box 7100, Beverly, MA 01915 0091, USA
    Biochim Biophys Acta 1768:167-74. 2007
    ..To test this hypothesis, we measured the effects of various carotenoids on rates of lipid peroxidation and correlated these findings with their membrane interactions, as determined by small angle X-ray ..
  65. ncbi Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden
    E P Simpson
    Department of Neurology, Baylor College of Medicine, Houston, TX, USA
    Neurology 62:1758-65. 2004
    ..Markers of oxidative stress and immune activation are significantly elevated in postmortem ALS CNS tissue, although the relevance to pathogenesis is unclear...
  66. ncbi The change of oxidative stress products in diabetes mellitus and diabetic retinopathy
    Hong Zhi Pan
    First Affiliated Hospital of the Harbin Medical University, No 23 Youzheng Street, Nangang District, Harbin, Heilongjiang, 150001, China
    Br J Ophthalmol 92:548-51. 2008
    ..The aim of this study is to detect oxidative stress parameters in type 2 diabetes mellitus with or without retinopathy and to investigate the relationship between oxidative stress and patients with type 2 diabetic retinopathy...
  67. ncbi Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis
    Naga Chalasani
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Gastroenterol 99:1497-502. 2004
    Products of systemic lipid peroxidation are important in the pathogenesis of cardiovascular disease...
  68. ncbi Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin--the antioxidant proteins
    Abha Chauhan
    NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314, USA
    Life Sci 75:2539-49. 2004
    Autism is a neurological disorder of childhood with poorly understood etiology and pathology. We compared lipid peroxidation status in the plasma of children with autism, and their developmentally normal non-autistic siblings by ..
  69. ncbi Cadmium induces reactive oxygen species generation and lipid peroxidation in cortical neurons in culture
    E Lopez
    Instituto de Bioquímica Centro Mixto CSIC UCM, Facultad de Farmacia, 28040 Madrid, Spain
    Free Radic Biol Med 40:940-51. 2006
    ..Necrotic death could be mediated by lipid peroxidation induced by cadmium through an indirect mechanism (ROS formation)...
  70. ncbi Role of glutathione peroxidase in protecting mammalian spermatozoa from loss of motility caused by spontaneous lipid peroxidation
    J G Alvarez
    Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, 19104 6080
    Gamete Res 23:77-90. 1989
    ..Recent work has shown that loss of sperm motility in these species correlates with the extent of spontaneous lipid peroxidation. In this study, the effect of H2O2 on this reaction in sperm of the three species was investigated...
  71. ncbi Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments
    M Bilici
    Department of Psychiatry, School of Medicine, Karadeniz Technical University, 61080, Trabzon, Turkey
    J Affect Disord 64:43-51. 2001
    ..and abnormalities in lipid compounds may cause overproduction of ROS and, in turn, antioxidative enzyme activities (AEAs) and lipid peroxidation (LP), and that these phenomena may be related to pathophysiology of major depression.
  72. pmc Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal
    Sung Chun Tang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Exp Neurol 213:114-21. 2008
    ..we report that TLR4 expression increases in neurons when exposed to amyloid beta-peptide (Abeta1-42) or the lipid peroxidation product 4-hydroxynonenal (HNE)...
  73. pmc Exploring the biology of lipid peroxidation-derived protein carbonylation
    Kristofer S Fritz
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    Chem Res Toxicol 24:1411-9. 2011
    ..The accumulation of reactive aldehydes resulting from sustained oxidative stress and lipid peroxidation is an underlying factor in the development of these pathologies...
  74. ncbi CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice
    Young Sun Kang
    Division of Nephrology, Department of Internal Medicine, Korea University, Ansan City, Korea
    Kidney Int 78:883-94. 2010
    ..Hence, our findings suggest that CCR2 antagonists can improve insulin resistance by modulation of the adipose tissue and restore renal function through both metabolic and anti-fibrotic effects in type 2 diabetic mice...
  75. pmc Association of GSTM1 and GSTT1 polymorphism with lipid peroxidation in benign prostate hyperplasia and prostate cancer: a pilot study
    Vivek Kumar
    Department of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, Dilshad Garden, Delhi, India
    Dis Markers 30:163-9. 2011
    ..Double deletion (GSTM1-/GSTT1-) is associated with higher oxidative stress which might play a role in the pathogenesis of BPH and prostate cancer. However, other markers of oxidative stress should be analyzed before any firm conclusion...
  76. ncbi Puerarin protects rat kidney from lead-induced apoptosis by modulating the PI3K/Akt/eNOS pathway
    Chan Min Liu
    School of Life Science, Xuzhou Normal University, No 101, Shanghai Road, Tangshan New Area, Xuzhou City 221116, Xuzhou City, Jiangsu Province, PR China
    Toxicol Appl Pharmacol 258:330-42. 2012
    ..elevation of reactive oxygen species (ROS) production and oxidative stress, as evidenced by increasing of lipid peroxidation level and depleting of intracellular reduced glutathione (GSH) level in kidney, were suppressed by treatment ..
  77. ncbi Protective effects of curcumin against sodium fluoride-induced toxicity in rat kidneys
    Seyed Fazel Nabavi
    National elites foundation of Iran, Tehran, Iran
    Biol Trace Elem Res 145:369-74. 2012
    ..After 1 week, lipid peroxidation level, activities of superoxide dismutase, catalase, and level of glutathione in kidney homogenate were ..
  78. ncbi Relationship between (Na + K)-ATPase activity, lipid peroxidation and fatty acid profile in erythrocytes of hypertensive and normotensive subjects
    Ramón Rodrigo
    Laboratory of Renal Pathophysiology, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Casilla, 70058, Santiago 7, Chile
    Mol Cell Biochem 303:73-81. 2007
    Oxidative stress may play a role in the pathogenic mechanism of essential hypertension. Lipid peroxidation can alter the cellular structure of membrane-bound enzymes by changing the membrane phospholipids fatty acids composition...
  79. ncbi Experimental exposure to wood-smoke particles in healthy humans: effects on markers of inflammation, coagulation, and lipid peroxidation
    Lars Barregard
    Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital and Academy, Goteborg University, Goteborg, Sweden
    Inhal Toxicol 18:845-53. 2006
    ..to examine whether short-term exposure to wood smoke affects markers of inflammation, blood hemostasis, and lipid peroxidation in healthy humans...
  80. pmc Resveratrol and red wine function as antioxidants in the nervous system without cellular proliferative effects during experimental diabetes
    Carina Duarte Venturini
    Universidade Federal de Ciências da Saúde de Porto Alegre, Division of Pharmacology, Porto Alegre, Brazil
    Oxid Med Cell Longev 3:434-41. 2010
    ..b>Lipid peroxidation (TBARS), catalase and superoxide dismutase were measured to evaluate the oxidative stress and the BrdU-..
  81. ncbi Increased oxidative DNA damage, lipid peroxidation, and reactive oxygen species in cultured orbital fibroblasts from patients with Graves' ophthalmopathy: evidence that oxidative stress has a role in this disorder
    C C Tsai
    Department of Ophthalmology, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
    Eye (Lond) 24:1520-5. 2010
    ..We investigated the oxidative stress in orbital fibroadipose tissues and cultured orbital fibroblasts from patients with Graves' ophthalmopathy (GO)...
  82. ncbi Activation of stress signaling pathways by the end product of lipid peroxidation. 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production
    K Uchida
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    J Biol Chem 274:2234-42. 1999
    ..and the AP-1-induced transcription of xenobiotic-metabolizing enzymes, these data may show a potential critical role for JNK in the induction of a cellular defense program against toxic products generated from lipid peroxidation.
  83. ncbi Antioxidant enzyme activities and oxidative stress in affective disorders
    M Erkan Ozcan
    Department of Psychiatry, Inonu University Medical School, Malatya, Turkey
    Int Clin Psychopharmacol 19:89-95. 2004
    ..The results of several reports suggest that lower antioxidant defences against lipid peroxidation exist in patients with depression and that there is a therapeutic benefit from antioxidant supplementation ..
  84. ncbi l-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB pathways
    Tae Il Kim
    College of Pharmacy and CBITRC, Chungbuk National University, Cheongju, Chungbuk 361 763, Korea
    Free Radic Biol Med 47:1601-10. 2009
    ..Thus, l-theanine may be useful in the prevention and treatment of AD...
  85. ncbi Radiation-induced lipid peroxidation activates src kinase and triggers nuclear EGFR transport
    Klaus Dittmann
    Department of Radiation Oncology, Eberhard Karls University, Röntgenweg, Germany
    Radiother Oncol 92:379-82. 2009
    ..Elucidation of the molecular mechanism of radiation-induced activation of src kinase, which initiates EGFR internalization and nuclear transport...
  86. pmc Protection of pancreatic beta-cells by group VIA phospholipase A(2)-mediated repair of mitochondrial membrane peroxidation
    Zhengshan Zhao
    Division of Experimental Diabetes and Aging, Department of Geriatrics and Adult Development, One Gustave L Levy Place, Mount Sinai School of Medicine, New York, NY 10029, USA
    Endocrinology 151:3038-48. 2010
    ..The low iPLA(2)beta expression level in db/db mouse beta-cells may render them vulnerable to injury by reactive oxygen species...
  87. ncbi Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action
    Tim U Krohne
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Exp Eye Res 90:261-6. 2010
    ..We previously demonstrated that lipid peroxidation-related protein modifications inhibit lysosomal degradation of photoreceptor outer segment (POS) proteins in ..
  88. pmc Reactive oxygen species mediate liver injury through parenchymal nuclear factor-kappaB inactivation in prolonged ischemia/reperfusion
    Laura Llacuna
    Liver Unit, Hospital Clinic, Institut de Investigacions Biomèdiques August Pi Sunyer, Centro de Investigaciones Biomédicas Esther Koplowitz, Universitat de Barcelona, Barcelona, Spain
    Am J Pathol 174:1776-85. 2009
    ....
  89. ncbi Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD
    Tanea T Reed
    Department of Chemistry, Center of Membrane Sciences, and Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA
    Brain Res 1274:66-76. 2009
    ..Oxidative stress in brain is reported in MCI and AD, including lipid peroxidation indexed by protein-bound 4-hydroxy-2-nonenal (HNE)...
  90. ncbi The levels of glutathione peroxidase, vitamin A, E, C and lipid peroxidation in patients with transitional cell carcinoma of the bladder
    O Yalcin
    Department of Urology, Firat Medical Centre, and Department of Chemistry, Faculty of Science and Literature, Firat University, 23119 Elazig, Turkey
    BJU Int 93:863-6. 2004
    ..To assess the levels of erythrocyte glutathione peroxidase (GSH-Px), and the serum levels of antioxidant vitamins (A, E and C), selenium and malondialdehyde (MDA) in patients with transitional cell carcinoma (TCC) of the bladder...
  91. ncbi S-allylcysteine inhibits free radical production, lipid peroxidation and neuronal damage in rat brain ischemia
    Y Numagami
    Philadelphia Biomedical Research Institute, King of Prussia, PA 19406, USA
    J Nutr 131:1100S-5S. 2001
    ..Although SAC did not attenuate the first peak, it did affect the second peak, which is related to lipid peroxidation. The lipid peroxidation as estimated by thiobarbituric acid reactive substances (TBARS) increased ..
  92. pmc Apple polyphenol extracts prevent damage to human gastric epithelial cells in vitro and to rat gastric mucosa in vivo
    G Graziani
    Dipartimento di Scienza degli Alimenti, Universita di Napoli, Italy
    Gut 54:193-200. 2005
    ..Fresh fruit and vegetables exert multiple biological effects on the gastrointestinal mucosa...
  93. ncbi Medicinal values of fruit peels from Citrus sinensis, Punica granatum, and Musa paradisiaca with respect to alterations in tissue lipid peroxidation and serum concentration of glucose, insulin, and thyroid hormones
    Hamendra Singh Parmar
    School of Life Sciences, Devi Ahilya University, Indore, MP, India
    J Med Food 11:376-81. 2008
    ..from Citrus sinensis, Punica granatum, and Musa paradisiaca were investigated for their effects on tissue lipid peroxidation (LPO) and on the concentration of thyroid hormones, insulin, and glucose in male rats...
  94. pmc Inhaled diesel emissions alter atherosclerotic plaque composition in ApoE(-/-) mice
    Matthew J Campen
    Toxicology Division, Lovelace Respiratory Research Institute, Albuquerque, NM, USA
    Toxicol Appl Pharmacol 242:310-7. 2010
    ..Diesel induced dose-related alterations in gene markers of vascular remodeling and aortic lipid peroxidation; filtration of PM did not significantly alter these vascular responses, indicating that the gaseous portion ..
  95. ncbi The lipid whisker model of the structure of oxidized cell membranes
    Michael E Greenberg
    Department of Cell Biology, Cleveland Clinic, Ohio 44195, USA
    J Biol Chem 283:2385-96. 2008
    ..Rather, our results suggest the following global phenomenon. As cellular membranes undergo lipid peroxidation, such as during senescence or apoptosis, previously hydrophobic portions of fatty acids will move from the ..
  96. ncbi Protective effects of zinc on lipid peroxidation, antioxidant enzymes and hepatic histoarchitecture in chlorpyrifos-induced toxicity
    Ajay Goel
    Department of Biophysics, Panjab University, Sector 14, Chandigarh 160014, India
    Chem Biol Interact 156:131-40. 2005
    ..The effects of these treatments were studied on various parameters in rat liver, including lipid peroxidation, antioxidant enzymes, levels of metallothionein (MT) and hepatic histoarchitecture...
  97. ncbi Antioxidant status and lipid peroxidation in type II diabetes mellitus
    Ramazan Memisogullari
    Department of Biochemistry, Medical School, Ataturk University, Erzurum, Turkey
    Cell Biochem Funct 21:291-6. 2003
    ..In this study, erythrocyte glutathione levels, lipid peroxidation, superoxide dismutase, catalase, and glutathione peroxidase and some extracellular antioxidant protein ..
  98. ncbi The flavonoid baicalin counteracts ischemic and oxidative insults to retinal cells and lipid peroxidation to brain membranes
    S H Jung
    Nuffield Laboratory of Ophthalmology, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Neurochem Int 53:325-37. 2008
    ..Moreover, a lipid peroxidation assay was used to compare the antioxidant capacity of baicalin with the flavonoid, epigallocatechin gallate (..
  99. ncbi Ameliorative effect of ajwain extract on hexachlorocyclohexane-induced lipid peroxidation in rat liver
    K R Anilakumar
    Biochemistry and Nutrition Discipline, Defence Food Research Laboratory, Mysore 570011, Karnataka, India
    Food Chem Toxicol 47:279-82. 2009
    ..Results revealed that HCH administration lead to an increase in hepatic lipid peroxidation associated with reduction in, levels of glutathione (GSH), activity of superoxide dismutase (SOD), catalase ..
  100. ncbi Lipid peroxidation and antioxidant enzyme activities in infertile men: correlation with semen parameter
    Fatma Ben Abdallah
    Human Pathologies and Oxidative Stress Unit, Superior Institute of Biotechnology of Sfax, Sfax, Tunisia
    J Clin Lab Anal 23:99-104. 2009
    ..05). In conclusion, our results suggest that the evaluation of oxidative status and antioxidant defenses may be taken as an important tool for diagnosis and treatment of male infertility...
  101. ncbi Antioxidative and hepatoprotective effects of magnolol on acetaminophen-induced liver damage in rats
    Yung Hsiang Chen
    Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan
    Arch Pharm Res 32:221-8. 2009
    ..01, 0.1, and 1 mug/kg). Histological changes around the hepatic central vein, lipid peroxidation (thiobarbituric acid-reactive substance/TBARS), and GSH depletion in liver tissue induced by APAP were also ..

Research Grants10

  1. MOLECULAR MECHANISMS OF OXIDATION OF LDL
    Sampath Parthasarathy; Fiscal Year: 1999
    ..B (apoB) and amino phospholipids (phosphatidylethanolamine) of LDL play a role in the propagation of lipid peroxidation and in the generation of oxidized LDL...
  2. OXIDANT MECHANISMS IN MEMBRANOUS NEPHROPATHY
    Sudhir Shah; Fiscal Year: 1993
    ..B. To examine the effect of anti-Fx1A antibody on glomerular GSH, GSSG levels, GSSG/GSH ratios and lipid peroxidation. The detection of enhanced lipid peroxidation and changes in glutathione (GSH) "oxidized" glutathione, (GSSG)..
  3. FREE RADICAL LIPID PEROXIDATION DAMAGE
    ALOYS TAPPEL; Fiscal Year: 1991
    Long-term objectives are (i) to advance knowledge of lipid peroxidation in animal tissues, with a major focus on the interaction of toxic initiators and antioxygenic protectors as determined by differential biochemical damage to lipids, ..
  4. Metals in exhaled breath condensate as COPD biomarkers
    Antonio Mutti; Fiscal Year: 2005
    ..LC-MS/MS) will be used as a complementary approach to develop biomarkers of effect (aldehydes from lipid peroxidation) suitable for the long-term monitoring of COPD patients...
  5. LIPID PEROXIDATION IN COLORECTAL CANCER
    Manuela Gago Dominguez; Fiscal Year: 2009
    ..and folate) and risk-enhancing (alcohol intake) factors for colorectal cancer are associated with plasma lipid peroxidation products [malondialdehyde, (MDA) and lipid peroxides] among controls. 2.1...
  6. Refinement of LC/ESR/MS for Studying Lipid Free Radicals in Colon Cancer Growth
    Steven Qian; Fiscal Year: 2009
    ..In addition, PUFA-derived free radicals, the most reactive intermediates in 15-LOX and COX lipid peroxidation, have not yet been identified nor their bioactivities characterized in colon cancer progression due to the ..
  7. OXIDATIVE CELL INJURY: FIRST-EPISODE PSYCHOTIC PATIENTS
    Sahebarao Mahadik; Fiscal Year: 2002
    ..proposal is the initial findings from our previous studies of an impaired antioxidant defense and increased lipid peroxidation that were associated with the brain morphometric changes at the onset of psychosis...
  8. EFFECT OF VITAMIN E ON HEPATOCYTE STRUCTURE AND FUNCTION
    Ronald Sokol; Fiscal Year: 1991
    ..E is the primary membrane-localized antioxidant protecting cellular membranes from free radical-induced lipid peroxidation. Infants and children with chronic forms of cholestatic hepatobiliary diseases frequently develop ..
  9. BREATH ETHANE, BIOMARKER OF VITAMIN A AND E DEFICIENCY
    Kathleen Schwarz; Fiscal Year: 1993
    ..Both vitamins exhibit potent antioxidant activity in vitro, and breath ethane (a volatile product of lipid peroxidation) is a useful index of vitamin E deficiency...
  10. Lipid peroxidation product induced DNA damage in the p53 gene and liver cancer
    ERIC MOON SHONG M TANG; Fiscal Year: 2010
    ..Rats on CDD therefore provide an excellent model for studying HCC. It has been found that the lipid peroxidation (LPO) level and LPO product-induced DNA damage are significantly increased in liver cells of rats on CDD;LPO ..