oxidation reduction

Summary

Summary: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).

Top Publications

  1. ncbi PAS domain S-boxes in Archaea, Bacteria and sensors for oxygen and redox
    I B Zhulin
    Department of Microbiology and Molecular Genetics, School of Medicine, Loma Linda University, CA 92350, USA
    Trends Biochem Sci 22:331-3. 1997
  2. ncbi Bacterial redox sensors
    Jeffrey Green
    Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    Nat Rev Microbiol 2:954-66. 2004
  3. ncbi Differential utilization of saturated palmitate and unsaturated oleate: evidence from cultured myotubes
    Michael Gaster
    Department of Endocrinology, Odense University Hospital, DK 5000 Odense, Denmark
    Diabetes 54:648-56. 2005
  4. ncbi Prokaryotic sulfur oxidation
    Cornelius G Friedrich
    Department of Biochemical and Chemical Engineering, University of Dortmund, D 44221 Dortmund, Germany
    Curr Opin Microbiol 8:253-9. 2005
  5. ncbi Fatty acid regulation of hepatic gene transcription
    Donald B Jump
    Departments of Physiology, Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA
    J Nutr 135:2503-6. 2005
  6. ncbi Isolation of an autotrophic ammonia-oxidizing marine archaeon
    Martin Könneke
    Department of Civil and Environmental Engineering, University of Washington, Seattle, Washington 98195, USA
    Nature 437:543-6. 2005
  7. ncbi ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
    Michel B Toledano
    CEA, iBiTecS, SBIGeM, Laboratoire Stress Oxydants et Cancer, Batiment 142, Commissariat à l Energie Atomique Saclay, 91191 Gif sur Yvette, France
    Nat Rev Mol Cell Biol 8:813-24. 2007
  8. pmc Oxidative protein folding in eukaryotes: mechanisms and consequences
    Benjamin P Tu
    Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 94143, USA
    J Cell Biol 164:341-6. 2004
  9. ncbi Pathways of oxidative damage
    James A Imlay
    Department of Microbiology, University of Illinois, Urbana, Illinois 61801, USA
    Annu Rev Microbiol 57:395-418. 2003
  10. pmc Archaeal nitrification in the ocean
    Cornelia Wuchter
    Department of Marine Biogeochemistry and Toxicology, Royal Netherlands Institute for Sea Research NIOZ, P O Box 59, 1790 AB, Den Burg, The Netherlands
    Proc Natl Acad Sci U S A 103:12317-22. 2006

Detail Information

Publications271 found, 100 shown here

  1. ncbi PAS domain S-boxes in Archaea, Bacteria and sensors for oxygen and redox
    I B Zhulin
    Department of Microbiology and Molecular Genetics, School of Medicine, Loma Linda University, CA 92350, USA
    Trends Biochem Sci 22:331-3. 1997
  2. ncbi Bacterial redox sensors
    Jeffrey Green
    Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    Nat Rev Microbiol 2:954-66. 2004
    ..Advances in biochemical analyses are revealing a range of elegant solutions that have evolved to allow bacteria to sense different redox signals...
  3. ncbi Differential utilization of saturated palmitate and unsaturated oleate: evidence from cultured myotubes
    Michael Gaster
    Department of Endocrinology, Odense University Hospital, DK 5000 Odense, Denmark
    Diabetes 54:648-56. 2005
    ..Neither acute hyperglycemia nor de novo lipid synthesis from glucose seems central to the TAG accumulation in obesity or type 2 diabetes...
  4. ncbi Prokaryotic sulfur oxidation
    Cornelius G Friedrich
    Department of Biochemical and Chemical Engineering, University of Dortmund, D 44221 Dortmund, Germany
    Curr Opin Microbiol 8:253-9. 2005
    ..This indicates a different pathway for oxidation of sulfur to sulfate. Acidophilic bacteria oxidize sulfur by a system different from the Sox enzyme system, as do chemotrophic endosymbiotic bacteria...
  5. ncbi Fatty acid regulation of hepatic gene transcription
    Donald B Jump
    Departments of Physiology, Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA
    J Nutr 135:2503-6. 2005
    ..Many of these mechanisms are regulated by PPARalpha or SREBP-1c. Together, these mechanisms control hepatic lipid composition and affect whole-body lipid composition...
  6. ncbi Isolation of an autotrophic ammonia-oxidizing marine archaeon
    Martin Könneke
    Department of Civil and Environmental Engineering, University of Washington, Seattle, Washington 98195, USA
    Nature 437:543-6. 2005
    ..The autotrophic metabolism of this isolate, and its close phylogenetic relationship to environmental marine crenarchaeal sequences, suggests that nitrifying marine Crenarchaeota may be important to global carbon and nitrogen cycles...
  7. ncbi ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
    Michel B Toledano
    CEA, iBiTecS, SBIGeM, Laboratoire Stress Oxydants et Cancer, Batiment 142, Commissariat à l Energie Atomique Saclay, 91191 Gif sur Yvette, France
    Nat Rev Mol Cell Biol 8:813-24. 2007
    ..By taking advantage of the chemistry of ROS, highly specific mechanisms have evolved that form the basis of oxidant scavenging and ROS signalling systems...
  8. pmc Oxidative protein folding in eukaryotes: mechanisms and consequences
    Benjamin P Tu
    Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 94143, USA
    J Cell Biol 164:341-6. 2004
    ..How Ero1p distinguishes between the many different PDI-related proteins and how the cell minimizes the effects of oxidative damage from Ero1 remain important open questions...
  9. ncbi Pathways of oxidative damage
    James A Imlay
    Department of Microbiology, University of Illinois, Urbana, Illinois 61801, USA
    Annu Rev Microbiol 57:395-418. 2003
    ..The vulnerability of cells to oxidation lies at the root of obligate anaerobiosis, spontaneous mutagenesis, and the use of oxidative stress as a biological weapon...
  10. pmc Archaeal nitrification in the ocean
    Cornelia Wuchter
    Department of Marine Biogeochemistry and Toxicology, Royal Netherlands Institute for Sea Research NIOZ, P O Box 59, 1790 AB, Den Burg, The Netherlands
    Proc Natl Acad Sci U S A 103:12317-22. 2006
    ..Our data thus suggest a major role for Archaea in oceanic nitrification...
  11. ncbi Investigating mitochondrial redox potential with redox-sensitive green fluorescent protein indicators
    George T Hanson
    Department of Biology, Institute of Molecular Biology, University of Oregon, Eugene, OR 97403 1229, USA
    J Biol Chem 279:13044-53. 2004
    ..T. Dooley, T. M. Dore, G. Hanson, W. C. Jackson, S. J. Remington, and R. Y. Tsien, submitted for publication), it is shown that the cytosol of HeLa cells is also unusually reducing but somewhat less so than the mitochondrial matrix...
  12. ncbi Regulation of PTP1B via glutathionylation of the active site cysteine 215
    W C Barrett
    Laboratory of Biochemistry, Section of Metabolic Regulation, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA
    Biochemistry 38:6699-705. 1999
    ..Glutathionylation of the cysteine sulfenic derivative will prevent the enzyme from further oxidation to its irreversible forms, and constitutes an efficient regulatory mechanism...
  13. ncbi Structure, mechanism and regulation of peroxiredoxins
    Zachary A Wood
    Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA
    Trends Biochem Sci 28:32-40. 2003
    ..Using crystal structures, a detailed catalytic cycle has been derived for typical 2-Cys Prxs, including a model for the redox-regulated oligomeric state proposed to control enzyme activity...
  14. ncbi Reversible inactivation of the tumor suppressor PTEN by H2O2
    Seung Rock Lee
    Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 8015, USA
    J Biol Chem 277:20336-42. 2002
    ....
  15. pmc The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
    R B Vega
    Center for Cardiovascular Research, Departments of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 20:1868-76. 2000
    ....
  16. ncbi Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling
    Zachary A Wood
    Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97333, USA
    Science 300:650-3. 2003
    ..We suggest this adaptation allows 2-Cys Prxs to act as floodgates, keeping resting levels of hydrogen peroxide low, while permitting higher levels during signal transduction...
  17. ncbi Reconciling the chemistry and biology of reactive oxygen species
    Christine C Winterbourn
    Department of Pathology and National Research Centre for Growth and Development, University of Otago Christchurch, PO Box 4345, Christchurch 8040, New Zealand
    Nat Chem Biol 4:278-86. 2008
    ..It also highlights areas where greater understanding is required on the fate of oxidants generated by cellular NADPH oxidases and on the identification of oxidant sensors in cell signaling...
  18. pmc Antioxidants, oxidative damage and oxygen deprivation stress: a review
    Olga Blokhina
    Department of Biosciences, Division of Plant Physiology, Viikki Biocenter, FIN 00014 Helsinki University, Finland
    Ann Bot 91:179-94. 2003
    ....
  19. ncbi Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD
    Andrei V Budanov
    Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Science 304:596-600. 2004
    ..As modulators of peroxide signaling and antioxidant defense, sestrins constitute potential therapeutic targets...
  20. ncbi Free radical-mediated oxidation of free amino acids and amino acid residues in proteins
    E R Stadtman
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 8012, USA
    Amino Acids 25:207-18. 2003
    ....
  21. ncbi Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family
    S DeWilde
    Department of Biochemistry, University of Antwerp, B 2610 Antwerp, Belgium
    J Biol Chem 276:38949-55. 2001
    ..The biochemical and kinetic characteristics are discussed in view of the possible functions of neuroglobin in the vertebrate brain...
  22. ncbi Mitochondrial reactive oxygen species in cell death signaling
    Christophe Fleury
    CNRS UPRES A 8087, Laboratoire de génétique moléculaire et physiologique de l EPHE, Universite de Versailles Saint Quentin, Batiment Fermat, 45, Avenue des Etats Unis, 78035 Versailles Cedex, France
    Biochimie 84:131-41. 2002
    ..Furthermore, the fact that active forms of cell death in yeast and plants also involve ROS suggests the existence of an ancestral redox-sensitive death signaling pathway that has been independent of caspases and Bcl-2...
  23. ncbi Oxidant signals and oxidative stress
    Toren Finkel
    Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1622, USA
    Curr Opin Cell Biol 15:247-54. 2003
    ..These new studies have significantly altered our understanding of how reactive oxygen species participate in diverse processes from tumourigenesis to ageing...
  24. ncbi Free radicals in the physiological control of cell function
    Wulf Dröge
    Division of Immunochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Physiol Rev 82:47-95. 2002
    ..There is growing evidence that aging involves, in addition, progressive changes in free radical-mediated regulatory processes that result in altered gene expression...
  25. ncbi Phylogenetic relationships of Thiomicrospira species and their identification in deep-sea hydrothermal vent samples by denaturing gradient gel electrophoresis of 16S rDNA fragments
    G Muyzer
    Molecular Ecology Unit, Max Planck Institute for Marine Microbiology, Fahrenheitstrasse 1, D 28359 Bremen, Germany
    Arch Microbiol 164:165-72. 1995
    ..The third 'phylotype' was identified as a Desulfovibrio, indicating that sulfate-reducing bacteria, as sources of sulfide, may complement sulfur- and sulfide-oxidizing bacteria ecologically in these sulfide-producing hydrothermal vents...
  26. pmc Stimulating the in situ activity of Geobacter species to remove uranium from the groundwater of a uranium-contaminated aquifer
    Robert T Anderson
    Department of Microbiology, University of Massachusetts, Morrill Science Center, Amherst, Massachusetts 01003, USA
    Appl Environ Microbiol 69:5884-91. 2003
    ..These results demonstrate that in situ bioremediation of uranium-contaminated groundwater is feasible but suggest that the strategy should be optimized to better maintain long-term activity of Geobacter species...
  27. ncbi Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators
    Colette T Dooley
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California 92093 0647, USA
    J Biol Chem 279:22284-93. 2004
    ..g. epidermal growth factor and lysophosphatidic acid...
  28. pmc Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor
    Barbara Ukropcova
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Clin Invest 115:1934-41. 2005
    ..The interindividual variability in metabolic phenotypes was preserved in human myotubes separated from their neuroendocrine environment, which supports the hypothesis that metabolic switching is an intrinsic property of skeletal muscle...
  29. ncbi Thiol chemistry and specificity in redox signaling
    Christine C Winterbourn
    Free Radical Research Group and the National Research Centre for Growth and Development, Department of Pathology, University of Otago, Christchurch, New Zealand
    Free Radic Biol Med 45:549-61. 2008
    ..We discuss areas where observations in cell systems can be rationalized with the reactivity of specific oxidants and where further work is needed to understand the mechanisms involved...
  30. ncbi Activation of the OxyR transcription factor by reversible disulfide bond formation
    M Zheng
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Science 279:1718-21. 1998
    ..The redox potential of OxyR was determined to be -185 millivolts, ensuring that OxyR is reduced in the absence of stress. These results represent an example of redox signaling through disulfide bond formation and reduction...
  31. pmc Increased atherosclerosis in myeloperoxidase-deficient mice
    M L Brennan
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles UCLA, Los Angeles, California, USA
    J Clin Invest 107:419-30. 2001
    ..They also identify an important distinction between murine and human atherosclerosis with regard to the potential involvement of MPO in protein oxidation...
  32. ncbi The function of peroxiredoxins in plant organelle redox metabolism
    Karl Josef Dietz
    Biochemistry and Physiology of Plants, W5 134, Bielefeld University, D 33501 Bielefeld, Germany
    J Exp Bot 57:1697-709. 2006
    ..Following a more general introduction, the paper summarizes present knowledge on plant organellar Prx, addressing Prx in signalling, and also suggests some lines for future research...
  33. ncbi NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences
    Weihai Ying
    Department of Neurology, University of California at San Francisco, San Francisco, California 94121, USA
    Antioxid Redox Signal 10:179-206. 2008
    ..Future investigation into the metabolism and biological functions of NAD and NADP may expose fundamental properties of life, and suggest new strategies for treating diseases and slowing the aging process...
  34. ncbi Thioredoxins and glutaredoxins as facilitators of protein folding
    Carsten Berndt
    The Medical Nobel Institute for Biochemistry, Karolinska Institutet, Stockholm, Sweden
    Biochim Biophys Acta 1783:641-50. 2008
    ....
  35. pmc Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide
    Jun Lu
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:12288-93. 2007
    ..Blocking cancer cell DNA replication and repair and induction of oxidative stress by the inhibition of both Trx and GSH systems are suggested as cancer chemotherapeutic strategies...
  36. ncbi Redox modifications of protein-thiols: emerging roles in cell signaling
    Saibal Biswas
    Department of Biochemistry, Dr Ambedkar College, Nagpur, Maharashtra State, India
    Biochem Pharmacol 71:551-64. 2006
    ....
  37. pmc Redox-based regulation of signal transduction: principles, pitfalls, and promises
    Yvonne M W Janssen-Heininger
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Free Radic Biol Med 45:1-17. 2008
    ..We also attempt to highlight some of the current pitfalls and the approaches needed to advance this important area of biochemical and biomedical research...
  38. ncbi Dissimilatory Fe(III) and Mn(IV) reduction
    Derek R Lovley
    Department of Microbiology, University of Massachusetts Amherst, Amherst, MA 01003, USA
    Adv Microb Physiol 49:219-86. 2004
    ..In comparison with other respiratory processes, the study of Fe(III) and Mn(IV) reduction is in its infancy, but genome-enabled approaches are rapidly advancing our understanding of this environmentally significant physiology...
  39. ncbi PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress
    Sara B Cullinan
    Leonard and Madlyn Abramson Family Cancer Research Institute and Cancer Center, Department of Cancer Biology, University of Pennsylvania Cancer Center, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    J Biol Chem 279:20108-17. 2004
    ..Our data suggest that perturbations in cellular redox status sensitize cells to the harmful effects of endoplasmic reticulum stress, but that other factors are essential for apoptotic commitment...
  40. pmc Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta
    Niki L Reynaert
    Department of Pathology and Chemistry, University of Vermont, Burlington, 05405, USA
    Proc Natl Acad Sci U S A 103:13086-91. 2006
    ..Collectively, these findings demonstrate the physiological relevance of the S-glutathionylation-GRX redox module in controlling the magnitude of activation of the NF-kappaB pathway...
  41. ncbi Denaturing gradient gel electrophoresis (DGGE) approaches to study the diversity of ammonia-oxidizing bacteria
    Mette Haubjerg Nicolaisen
    Department of Microbial Ecology, Institute of Biological Sciences, University of Aarhus, Ny Munkegade, Building 540, DK 8000 C, Aarhus, Denmark
    J Microbiol Methods 50:189-203. 2002
    ..The majority of retrieved sequences from all four habitats with high ammonia loads were Nitrosomonas-like and only few Nitrosospira-like sequences were detected...
  42. pmc Mycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survival
    Amit Singh
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 104:11562-7. 2007
    ..Taken together, our results suggest that WhiB3 is an intracellular redox sensor that integrates environmental redox signals with core intermediary metabolism...
  43. ncbi The PerR transcription factor senses H2O2 by metal-catalysed histidine oxidation
    Jin Won Lee
    Department of Microbiology, Cornell University, Ithaca, New York 14853, USA
    Nature 440:363-7. 2006
    ....
  44. pmc Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life
    Barry Halliwell
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Plant Physiol 141:312-22. 2006
  45. pmc RsrA, an anti-sigma factor regulated by redox change
    J G Kang
    Department of Microbiology, College of Natural Sciences, and Research Center for Molecular Microbiology, Seoul National University, Seoul 151 742, Korea
    EMBO J 18:4292-8. 1999
    ..Thioredoxin was able to reduce oxidized RsrA, suggesting that sigma(R), RsrA and the thioredoxin system comprise a novel feedback homeostasis loop that senses and responds to changes in the intracellular thiol-disulfide redox balance...
  46. ncbi Methane as fuel for anaerobic microorganisms
    Rudolf K Thauer
    Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, D 35043 Marburg, Germany
    Ann N Y Acad Sci 1125:158-70. 2008
    ..The first step in methane oxidation is most likely the exergonic formation of 2-methylsuccinate from fumarate and methane catalyzed by a glycine-radical enzyme...
  47. pmc Chromate-reducing properties of soluble flavoproteins from Pseudomonas putida and Escherichia coli
    D F Ackerley
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    Appl Environ Microbiol 70:873-82. 2004
    ..The results nevertheless suggest that YieF may be an even more suitable candidate for further studies than ChrR...
  48. pmc Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice. Demonstration of epitopes of oxidized low density lipoprotein in human plasma
    W Palinski
    Department of Medicine, University of California, San Diego 92093, USA
    J Clin Invest 98:800-14. 1996
    ..The availability of "natural" monoclonal autoantibodies should facilitate the identification of specific epitopes inducing this response...
  49. ncbi Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate
    Annette Salmeen
    Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
    Nature 423:769-73. 2003
    ....
  50. ncbi Involvement of oxidative stress response genes in redox homeostasis, the level of reactive oxygen species, and ageing in Saccharomyces cerevisiae
    Tamara Drakulic
    Ramaciotti Centre for Gene Function Analysis and School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, Sydney, Australia
    FEMS Yeast Res 5:1215-28. 2005
    ..Heterogeneity was detected in populations of strains with compromised anti-oxidant defences, and as cells aged they shifted from one cell type with low ROS content to another with much higher intracellular ROS...
  51. ncbi Identification of a protein required for disulfide bond formation in vivo
    J C Bardwell
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Cell 67:581-9. 1991
    ..The purified DsbA protein is capable of reducing the disulfide bonds of insulin, an activity that it shares with these disulfide oxidoreductases. Our results suggest that disulfide bond formation is facilitated by DsbA in vivo...
  52. pmc The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice
    S Xanthoudakis
    Department of Central Nervous System Research, Hoffmann La Roche Inc, Nutley, NJ 07110, USA
    Proc Natl Acad Sci U S A 93:8919-23. 1996
    ..Degeneration of the mutant embryos is clearly evident at embryonic day 5.5. These findings demonstrate that Ref-1 is essential for early embryonic development...
  53. ncbi Peroxisome proliferator-activated receptor alpha target genes
    S Mandard
    Nutrition, Metabolism and Genomics Group, Wageningen University, 6700 Wageningen, The Netherlands
    Cell Mol Life Sci 61:393-416. 2004
    ....
  54. ncbi Total antioxidant capacity as a tool to assess redox status: critical view and experimental data
    A Ghiselli
    National Institute for Food and Nutrition Research Istituto Nazionale per la Ricerca su Alimenti e Nutrizione, 546 Via Ardeatina, 00178 Rome, Italy
    Free Radic Biol Med 29:1106-14. 2000
    ..Consequently, this review discusses the rationale, interpretation, confounding factors, measurement limits, and human applications of the measure of plasma AC...
  55. ncbi Archaea predominate among ammonia-oxidizing prokaryotes in soils
    S Leininger
    Department of Biology, University of Bergen, Jahnebakken 5, N 5020 Bergen, Norway
    Nature 442:806-9. 2006
    ..Our results indicate that crenarchaeota may be the most abundant ammonia-oxidizing organisms in soil ecosystems on Earth...
  56. ncbi Oxidative modification to cysteine sulfonic acid of Cys111 in human copper-zinc superoxide dismutase
    Noriko Fujiwara
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Hyogo, 663 8501, Japan
    J Biol Chem 282:35933-44. 2007
    ..These results suggest that Cys(111) is a primary target for oxidative modification and plays an important role in oxidative damage to human SOD1, including familial amyotrophic lateral sclerosis mutants...
  57. ncbi Identification of S-glutathionylated cellular proteins during oxidative stress and constitutive metabolism by affinity purification and proteomic analysis
    Christina Lind
    Division of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
    Arch Biochem Biophys 406:229-40. 2002
    ....
  58. pmc Selective redox regulation of cytokine receptor signaling by extracellular thioredoxin-1
    Ulla Schwertassek
    Redox Regulation Research Group, German Cancer Research Center DKFZ A160, Heidelberg, Germany
    EMBO J 26:3086-97. 2007
    ..Furthermore, we confirm that Trx1 affects CD30-dependent changes in lymphocyte effector function. Thus, we conclude that receptor-ligand signaling interactions can be selectively regulated by an extracellular redox catalyst...
  59. ncbi Reduced lipid oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin: evidence from cultured myotubes
    Michael Gaster
    Department of Endocrinology, Odense University Hospital, Odense, Denmark
    Diabetes 53:542-8. 2004
    ..These results indicate that the reduced lipid oxidation in diabetic skeletal muscle in vivo may be of genetic origin; it also appears that TAG metabolism is not primarily affected in diabetic muscles under basal physiological conditions...
  60. ncbi Roles of the glutathione- and thioredoxin-dependent reduction systems in the Escherichia coli and saccharomyces cerevisiae responses to oxidative stress
    O Carmel-Harel
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Microbiol 54:439-61. 2000
    ..coli OxyR and SoxR and the S. cerevisiae Yap1p transcriptional regulators of the adaptive responses to oxidative stress...
  61. ncbi Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins
    Sue Goo Rhee
    Laboratory of Cell Signaling, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Opin Cell Biol 17:183-9. 2005
    ....
  62. ncbi Anaerobic microbial dehalogenation
    Hauke Smidt
    Laboratory of Microbiology, Wageningen University, 6703CT Wageningen, The Netherlands
    Annu Rev Microbiol 58:43-73. 2004
    ....
  63. ncbi Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation
    U Ermler
    Max Planck Institut fur Biophysik, Heinrich Hoffmann Strabetae 7, 60528 Frankfurt, Germany
    Science 278:1457-62. 1997
    ..Together with a second structurally characterized enzyme state (MCRsilent) containing the heterodisulfide of coenzymes M and B, a reaction mechanism is proposed that uses a radical intermediate and a nickel organic compound...
  64. pmc Cloning and sequence of cymA, a gene encoding a tetraheme cytochrome c required for reduction of iron(III), fumarate, and nitrate by Shewanella putrefaciens MR-1
    C R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    J Bacteriol 179:1143-52. 1997
    ..The localization of the fumarate and iron(III) reductases to the periplasm and outer membrane of MR-1, respectively, suggests the possibility of a similar electron transfer role for CymA...
  65. ncbi Metagenome and mRNA expression analyses of anaerobic methanotrophic archaea of the ANME-1 group
    Anke Meyerdierks
    Max Planck Institute for Marine Microbiology, Celsiusstrasse 1, 28359 Bremen, Germany
    Environ Microbiol 12:422-39. 2010
    ..The genes were shown to be expressed, suggesting direct electron transfer as an additional possible mode to shuttle electrons from ANME-1 to the bacterial sulfate-reducing partner...
  66. ncbi Redox imbalance and its control in HIV infection
    Hajime Nakamura
    Department of Biological Responses, Institute for Virus Research, Kyoto University, 53 Shogin Kawaharacho, Sakyo, Kyoto 606 8507, Japan
    Antioxid Redox Signal 4:455-64. 2002
    ..Redox control will be an important therapeutic strategy for oxidative stress-associated disorders including HIV infection...
  67. ncbi Generation of reactive oxygen species by the mitochondrial electron transport chain
    Yuanbin Liu
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037 9062, USA
    J Neurochem 80:780-7. 2002
    ..These new insights clarify an elusive target for intervening mitochondrial ROS-related processes or diseases...
  68. pmc Redox homeostasis and antioxidant signaling: a metabolic interface between stress perception and physiological responses
    Christine H Foyer
    Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK
    Plant Cell 17:1866-75. 2005
  69. ncbi Mitochondrial redox biology and homeostasis in plants
    Graham Noctor
    Institut de Biotechnologie des Plantes, UMR CNRS 8618, Université de Paris XI, 91405 Orsay Cedex, France
    Trends Plant Sci 12:125-34. 2007
    ..In this review, mitochondrial redox metabolism is discussed in relation to the integrated cellular energy and redox function that controls plant cell biology and fate...
  70. pmc Quantifying changes in the thiol redox proteome upon oxidative stress in vivo
    Lars I Leichert
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 North University, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 105:8197-202. 2008
    ..These experiments illustrate that OxICAT, which can be used in a variety of different cell types and organisms, is a powerful tool to identify, quantify, and monitor oxidative thiol modifications in vivo...
  71. ncbi Gain of function in an ERV/ALR sulfhydryl oxidase by molecular engineering of the shuttle disulfide
    Elvira Vitu
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Mol Biol 362:89-101. 2006
    ....
  72. ncbi Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
    Timothy R Koves
    Sarah W Stedman Nutrition and Metabolism Center, Department of Medicine, Duke University, Durham, NC 27710, USA
    Cell Metab 7:45-56. 2008
    ..These findings reveal a strong connection between skeletal muscle insulin resistance and lipid-induced mitochondrial stress...
  73. ncbi Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactions
    Joakim Huber
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
    Arterioscler Thromb Vasc Biol 22:101-7. 2002
    ..In addition to oxidized lipoproteins, oxidized MVs and apoptotic blebs may play an important role in chronic inflammatory diseases, such as atherosclerosis...
  74. ncbi Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in ryanodine receptor type 1
    Paula Aracena-Parks
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 281:40354-68. 2006
    ..In summary, we have identified a discrete subset of cysteines that are likely to be involved in the functional response of RyR1 to different redox modifications (S-nitrosylation, S-glutathionylation, and oxidation to disulfides)...
  75. pmc Import of small Tim proteins into the mitochondrial intermembrane space
    Thomas Lutz
    Institut fur Physiologische Chemie, Universitat Munchen, Butenandtstrasse 5, 81377 Munchen, Germany
    EMBO J 22:4400-8. 2003
    ....
  76. ncbi Redox regulation of the G1 to S phase transition in the mouse embryo fibroblast cell cycle
    Sarita G Menon
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City 52242, USA
    Cancer Res 63:2109-17. 2003
    ....
  77. ncbi Exogenous carbohydrate oxidation during ultraendurance exercise
    Asker E Jeukendrup
    Human Performance Laboratory, School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Appl Physiol (1985) 100:1134-41. 2006
    ..The ingestion of Glu+Fru increases CHO(Exo) compared with the ingestion of Glu alone, potentially through the oxidation of CHO(Exo) in the liver or through the conversion to, and oxidation of, lactate...
  78. ncbi A novel mechanism of nuclear photosynthesis gene regulation by redox signals from the chloroplast during photosystem stoichiometry adjustment
    T Pfannschmidt
    Institute of General Botany, Department of Plant Physiology, University of Jena, Dornburger Strasse 159, 07743 Jena, Germany
    J Biol Chem 276:36125-30. 2001
    ..Thus, the expression of nuclear-encoded PSI genes is controlled by diverse light quality-dependent redox signals from the plastids during photosystem stoichiometry adjustment...
  79. ncbi Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Am J Clin Nutr 89:455S-62S. 2009
    ..These findings imply that obese individuals would benefit from interventions that increase the skeletal muscle mitochondrial content and the potential for oxidizing FAs...
  80. ncbi Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase
    S Hadjur
    Centre for Molecular Medicine and Therapeutics, British Columbia Research Institute for Children s and Women s Health, University of British Columbia, Vancouver, British Columbia, Canada
    Blood 98:1003-11. 2001
    ..These results suggested that the altered redox state likely present in Fancc(-/-) Sod1(-/-) hematopoietic progenitors was responsible for an impairment of cell proliferation or survival. (Blood. 2001;98:1003-1011)..
  81. ncbi Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein
    R Bryk
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Science 295:1073-7. 2002
    ..AhpD thus represents a class of thioredoxin-like molecules that enables an antioxidant defense...
  82. ncbi S-glutathionylation in protein redox regulation
    Isabella Dalle-Donne
    Department of Biology, University of Milan, I 20133 Milan, Italy
    Free Radic Biol Med 43:883-98. 2007
    ..In this review, we describe recent breakthroughs in our understanding of the potential role of protein S-glutathionylation in the redox regulation of signal transduction...
  83. pmc Calorie restriction extends yeast life span by lowering the level of NADH
    Su Ju Lin
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 18:12-6. 2004
    ..A genetic intervention that specifically decreases NADH levels increases life span, validating the model that NADH regulates yeast longevity in response to CR...
  84. ncbi A thiol peroxidase is an H2O2 receptor and redox-transducer in gene activation
    Agnes Delaunay
    Laboratoire Stress Oxydants et Cancers, SBGM, DBJC, CEA Saclay, 91191 Gif sur Yvette, Cedex, France
    Cell 111:471-81. 2002
    ..These data reveal a redox-signaling function for a GPx-like enzyme and elucidate a eukaryotic hydroperoxide-sensing mechanism. Gpx3 is thus a hydroperoxide receptor and redox-transducer...
  85. pmc The protein disulphide-isomerase family: unravelling a string of folds
    D M Ferrari
    Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D37077 Gottingen, Germany
    Biochem J 339:1-10. 1999
    ..Thus the presence of both redox-active and -inactive domains within these proteins portends a complexity of functions differentially accommodated by the various family members...
  86. pmc Novel genes of the dsr gene cluster and evidence for close interaction of Dsr proteins during sulfur oxidation in the phototrophic sulfur bacterium Allochromatium vinosum
    Christiane Dahl
    Institut für Mikrobiologie and Biotechnologie, Rheinische Friedrich Wilhelms Universitat Bonn, Meckenheimer Allee 168, D 53115 Bonn, Germany
    J Bacteriol 187:1392-404. 2005
    ....
  87. ncbi Redefining oxidative stress
    Dean P Jones
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Whitehead Biomedical Research Center, Emory University, Atlanta, Georgia 30322, USA
    Antioxid Redox Signal 8:1865-79. 2006
    ..Adoption of such a definition could redirect research to identify key perturbations of redox signaling and control and lead to new treatments for oxidative stress-related disease processes...
  88. pmc The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
    Rosa M Canet-Aviles
    Laboratory of Neurogenetics, National Institute on Aging, 9000 Rockville Pike, Bethesda, MD 20892 1589, USA
    Proc Natl Acad Sci U S A 101:9103-8. 2004
    ..We suggest that DJ-1 protects against neuronal death, and that this is signaled by acidification of the key cysteine residue, C106...
  89. ncbi Redox regulation of cardiac calcium channels and transporters
    Aleksey V Zima
    Department of Physiology, Stritch School of Medicine, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, USA
    Cardiovasc Res 71:310-21. 2006
    ..This article summarizes recent findings on redox regulation of cardiac Ca(2+) transport systems and discusses contributions of this redox regulation to normal and pathological cardiac function...
  90. ncbi Bacterial diversity and activity along a salinity gradient in soda lakes of the Kulunda Steppe (Altai, Russia)
    Mirjam J Foti
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Extremophiles 12:133-45. 2008
    ..Furthermore, the increase of sodium carbonate/bicarbonate seemed to affect the composition of the microbial community in soda lakes, but not the rate of sulfate reduction...
  91. pmc Identification of methyl coenzyme M reductase A (mcrA) genes associated with methane-oxidizing archaea
    Steven J Hallam
    Monterey Bay Aquarium Research Institute, Moss Landing, California 95039 9644, USA
    Appl Environ Microbiol 69:5483-91. 2003
    ..These results provide a basis for identifying methanotrophic archaea with mcrA sequences and define a functional genomic link between methanogenic and methanotrophic archaea...
  92. pmc The ascorbic acid redox state controls guard cell signaling and stomatal movement
    Zhong Chen
    Department of Biochemistry, University of California, Riverside, California 92521 0129, USA
    Plant Cell 16:1143-62. 2004
    ..Our analyses suggest that DHAR serves to maintain a basal level of Asc recycling in guard cells that is insufficient to scavenge the high rate of H(2)O(2) produced in the afternoon, thus resulting in stomatal closure...
  93. ncbi Redox regulation of protein tyrosine phosphatases during receptor tyrosine kinase signal transduction
    Paola Chiarugi
    Dipartimento di Scienze Biochimiche, Universita di Firenze, Viale Morgagni 50, 50134 Florence, Italy
    Trends Biochem Sci 28:509-14. 2003
    ..We propose that signal transduction by oxygen species through reversible phosphotyrosine phosphatase inhibition, represents a widespread and conserved component of the biochemical machinery that is triggered by RTKs...
  94. pmc Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells
    Nikolaos Dimopoulos
    Division of Molecular Physiology, Centre for Interdisciplinary Research, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 399:473-81. 2006
    ....
  95. ncbi Reactive oxygen signalling: the latest news
    Christophe Laloi
    Institute of Plant Sciences, Plant Genetics, Swiss Federal Institute of Technology ETH, CH 8092, Zurich, Switzerland
    Curr Opin Plant Biol 7:323-8. 2004
    ..Moreover, both the chemical identity of a given ROS and the intracellular site of its production seem to affect the specificity of its biological activity, further increasing the complexity of ROS signalling within plants...
  96. ncbi Muscle-derived ROS and thiol regulation in muscle fatigue
    Leonardo F Ferreira
    Department of Physiology, University of Kentucky, 800 Rose St, Lexington, KY 40536 0298, USA
    J Appl Physiol (1985) 104:853-60. 2008
    ..These findings highlight the importance of ROS and thiol chemistry in fatigue, show the feasibility of thiol-based countermeasures, and identify new directions for mechanistic and translational research...
  97. pmc Diversity of ammonia-oxidizing archaea and bacteria in the sediments of a hypernutrified subtropical estuary: Bahía del Tóbari, Mexico
    J Michael Beman
    Department of Geological and Environmental Sciences, Building 320, Room 118, Stanford University, Stanford, CA 94305 2115, USA
    Appl Environ Microbiol 72:7767-77. 2006
    ....
  98. ncbi The antioxidant properties of serum albumin
    Marjolaine Roche
    Laboratoire de Biochimie et Genetique Moleculaire, Universite de la Reunion, Saint Denis de La Réunion, France
    FEBS Lett 582:1783-7. 2008
    ..In particular, we describe the role of albumin in ligand binding and free radical-trapping activities. In addition, physiological and pathological situations that modify the antioxidant properties of albumin are reported...
  99. pmc Contrasting sensitivities of Escherichia coli aconitases A and B to oxidation and iron depletion
    Shery Varghese
    Department of Microbiology, University of Illinois, Urbana, IL 61801, USA
    J Bacteriol 185:221-30. 2003
    ..coli synthesizes a transport system. Thus, AcnB may be retained as the primary aconitase because the lability of its exposed cluster allows E. coli to sense and respond to iron depletion...
  100. ncbi In vitro demonstration of anaerobic oxidation of methane coupled to sulphate reduction in sediment from a marine gas hydrate area
    Katja Nauhaus
    Max Planck Institut für Marine Mikrobiologie, D 28359 Bremen, Germany
    Environ Microbiol 4:296-305. 2002
    ..Hence, the experiments did not provide evidence for one of these compounds acting as a free extracellular intermediate (intercellular shuttle) during AOM by the presently investigated consortia...
  101. pmc A cysteine-rich CCG domain contains a novel [4Fe-4S] cluster binding motif as deduced from studies with subunit B of heterodisulfide reductase from Methanothermobacter marburgensis
    Nils Hamann
    Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, D 35043 Marburg, Germany
    Biochemistry 46:12875-85. 2007
    ..In addition, Zn K-edge X-ray absorption spectroscopy identified an isolated Zn site with an S3(O/N)1 geometry in HdrB and the HDR holoenzyme. The N-terminal CCG domain is suggested to provide ligands to the Zn site...

Research Grants9

  1. Control of Cardiac Metabolism: NADH Shuttles/Hypertrophy
    Thomas Scholz; Fiscal Year: 2006
    ..A complete understanding of this pathway is essential to fully define the interaction between these two compartments. [unreadable] [unreadable]..
  2. REDOX PROPERTIES OF FLAVODOXIN-LIKE FLAVOPROTEINS
    RICHARD SWENSON; Fiscal Year: 2007
    ..These studies are also designed to expand our understanding of the fundamentally different way that the one electron reduced state (the flavin semiquinone) is stabilized and is utilized in these two different systems. ..
  3. REACTION MECHANISM OF MYOCARDIAC UBIQUINONE-PROTEINS
    Chang An Yu; Fiscal Year: 2009
    ..For type specifications, see instructions on page 6.) RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  4. METABOLISM AND NUTRITION OF IRON AND OTHER TRACE METALS
    PAUL SALTMAN; Fiscal Year: 1993
    ..There is a remarkable coherence among the three research goals in that site-specific binding, oxidation-reduction and chelation play significant roles in cellular metabolism of trace elements...
  5. HORMONAL REGULATION OF ENERGY METABOLISM
    Tarun Patel; Fiscal Year: 1993
    ....
  6. ELECTRON TRANSPORT ENZYMES IN CATECHOLAMINE GRANULES
    Patrick Fleming; Fiscal Year: 1990
    ..DBH was not previously known to be allosterically regulated. Thus, this characterization is necessary to permit an understanding of the regulation of catecholamine biosynthesis...
  7. Molecular mechanisms of oxidative stress resistance in an animal model of aging w
    Sarah Milton; Fiscal Year: 2009
    ....
  8. Biomimetic Microsystem for High Throughput Evaluation of Engineered Nanomaterials
    Robert M Worden; Fiscal Year: 2010
    ....
  9. GORDON RESEARCH CONFERENCE ON PYRROLES
    SAMUEL BEALE; Fiscal Year: 1990
    ..Because of the breadth of coverage, the conference is considered by many of the participants to be the most important conference attended...