Genomes and Genes
Summary: The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent.
Publications319 found, 100 shown here
- Response of Leptospira interrogans to physiologic osmolarity: relevance in signaling the environment-to-host transitionJames Matsunaga
Research Service, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Infect Immun 75:2864-74. 2007..These findings suggest that physiologic osmolarity is an important signal for regulation of gene expression by pathogenic leptospires during transition from ambient conditions to the host tissue environment...
- GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity glycerol response pathwayJ Albertyn
Department of Microbiology and Biochemistry, Faculty of Science, University of the Orange Free State, Bloemfontein, South Africa
Mol Cell Biol 14:4135-44. 1994..Thus, the HOG pathway most probably has additional targets in the mechanism of adaptation to hypertonic medium...
- Osmosensing by bacteria: signals and membrane-based sensorsJ M Wood
Department of Microbiology and Guelph Waterloo Centre for Graduate Work in Chemistry, University of Guelph, Guelph, Ontario, Canada N1G
Microbiol Mol Biol Rev 63:230-62. 1999..Thus, osmoregulatory responses accommodate and exploit the effects of individual cosolvents on cell structure and function as well as the collective contribution of cosolvents to intracellular osmolality...
- Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways diseaseH Matsui
Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, 27599 7248, USA
Cell 95:1005-15. 1998..These data indicate that therapy for CF lung disease should not be directed at modulation of ionic composition, but rather at restoring volume (salt and water) on airway surfaces...
- Human hydration indices: acute and longitudinal reference valuesLawrence E Armstrong
Human Performance Laboratory, University of Connecticut, Storrs, CT, USA
Int J Sport Nutr Exerc Metab 20:145-53. 2010..These findings provide euhydration reference values and hydration extremes for 7 commonly used indices in free-living, healthy, active men who were not exercising in a hot environment or training strenuously...
- Saliva parameters as potential indices of hydration status during acute dehydrationNeil P Walsh
School of Sport, Health and Exercise Sciences, University of Wales, Bangor, United Kingdom
Med Sci Sports Exerc 36:1535-42. 2004....
- Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stressesPaul H Yancey
Biology Department, Whitman College, Walla Walla, WA 99362, USA
J Exp Biol 208:2819-30. 2005..Some of these solutes have applications in biotechnology, agriculture and medicine, including in vitro rescue of the misfolded protein of cystic fibrosis. However, caution is warranted if high levels cause overstabilization of proteins...
- Assessing hydration status: the elusive gold standardLawrence E Armstrong
Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT 06269 1110, USA
J Am Coll Nutr 26:575S-584S. 2007....
- Reference change values for monitoring dehydrationSamuel N Cheuvront
U S Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, Natick, MA 01760 5007, USA
Clin Chem Lab Med 49:1033-7. 2011..A secondary purpose was to validate use of the tool by dehydrating a group of volunteers...
- Central mechanisms of osmosensation and systemic osmoregulationCharles W Bourque
Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Room L7 216, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, H3G 1A4, Canada
Nat Rev Neurosci 9:519-31. 2008..Here, recent advances in our understanding of the molecular, cellular and network mechanisms that mediate the central control of osmotic homeostasis in mammals are reviewed...
- Phosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolarityJosep Clotet
Department of Molecular and Cellular Biology, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Spain
EMBO J 25:2338-46. 2006....
- Sphingolipids regulate the yeast high-osmolarity glycerol response pathwayMirai Tanigawa
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
Mol Cell Biol 32:2861-70. 2012..These observations reveal the sphingolipid-mediated regulation of the osmosensing machinery of the HOG pathway...
- The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiaeS M O'Rourke
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143 0448, USA
Genes Dev 12:2874-86. 1998..Finally, we have found that pseudohyphal growth exhibited by wild-type (HOG1) strains depends on SHO1, suggesting that Sho1p may be a receptor that feeds into the pseudohyphal growth pathway...
- Dehydration in hospital-admitted stroke patients: detection, frequency, and associationAnne Rowat
Edinburgh Napier University, School of Nursing and Midwifery and Social Care, Edinburgh, Scotland
Stroke 43:857-9. 2012..We aimed to determine the frequency of dehydration, risk factors, and associations with outcomes at hospital discharge after stroke...
- Identification and characterization of OscR, a transcriptional regulator involved in osmolarity adaptation in Vibrio choleraeNicholas J Shikuma
Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California 95064, USA
J Bacteriol 191:4082-96. 2009..oscR mutants were less motile and exhibited enhanced biofilm formation only under low-salt conditions...
- Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatasesS M Wurgler-Murphy
Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Mol Cell Biol 17:1289-97. 1997..Thus, the kinase activity of Hog1p is required for its own tyrosine dephosphorylation. Northern blot analyses suggest that Hog1p regulates Ptp2p and/or Ptp3p activity at the posttranscriptional level...
- Sorption of 243Am(III) to multiwall carbon nanotubesXiangke Wang
Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, People s Republic of China
Environ Sci Technol 39:2856-60. 2005....
- Osmoregulation of taurine transporter function and expression in retinal pigment epithelial, ganglion, and müller cellsAmira El-Sherbeny
Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912 2000, USA
Invest Ophthalmol Vis Sci 45:694-701. 2004..To determine whether taurine transporter (TauT) activity and expression are regulated by hyperosmolarity in RPE, ganglion, and Müller cells...
- Hyperosmolality causes growth arrest of murine kidney cells. Induction of GADD45 and GADD153 by osmosensing via stress-activated protein kinase 2D Kultz
Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
J Biol Chem 273:13645-51. 1998....
- Assessing hydration statusStavros A Kavouras
Laboratory of Nutrition and Clinical Dietetics, Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
Curr Opin Clin Nutr Metab Care 5:519-24. 2002..Understanding the importance of euhydration in humans in order to ensure good health in various situations, the purpose of this review is to examine the available techniques in assessing hydration status...
- Effect of water deprivation on cognitive-motor performance in healthy men and womenGabor Szinnai
Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine, University Hospital, CH 4031 Basel, Switzerland
Am J Physiol Regul Integr Comp Physiol 289:R275-80. 2005..Increased subjective task-related effort suggests that healthy volunteers exhibit cognitive compensating mechanisms for increased tiredness and reduced alertness during slowly progressive moderate dehydration...
- Removal of Pb(II) from aqueous solution by oxidized multiwalled carbon nanotubesDi Xu
Institute of Plasma Physics, Chinese Academy of Sciences, P O Box 1126, 230031 Hefei, China
J Hazard Mater 154:407-16. 2008....
- Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channelsT Ma
Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
J Biol Chem 273:4296-9. 1998..The results suggest that AQP1 knockout mice are unable to create a hypertonic medullary interstitium by countercurrent multiplication. AQP1 is thus required for the formation of a concentrated urine by the kidney...
- Reciprocal regulation of plasma apelin and vasopressin by osmotic stimuliMichel Azizi
Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Universite Paris Descartes, Faculte de Medecine, and INSERM, CIC 9201, Paris, France
J Am Soc Nephrol 19:1015-24. 2008
- Conditions for the triggering of spreading depression studied with computer simulationsH Kager
Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
J Neurophysiol 88:2700-12. 2002....
- The RA domain of Ste50 adaptor protein is required for delivery of Ste11 to the plasma membrane in the filamentous growth signaling pathway of the yeast Saccharomyces cerevisiaeDagmar M Truckses
Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Room 16, Barker Hall, Berkeley, CA 94720 3202, USA
Mol Cell Biol 26:912-28. 2006..Thus, Ste50 serves as an adaptor to tether Ste11 to the plasma membrane and can do so via association with Cdc42, thereby permitting the encounter of Ste11 with activated Ste20...
- Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cellsDe Quan Li
Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA
Invest Ophthalmol Vis Sci 45:4302-11. 2004....
- Time-dependent proteome alterations under osmotic stress during aerobic and anaerobic growth in Escherichia coliArnim Weber
Ludwig Maximilians Universitat Munchen, Department Biologie I, Bereich Mikrobiologie, Maria Ward Str 1a, D 80638 München, Germany
J Bacteriol 188:7165-75. 2006..Only a few proteins were found to be down-regulated upon osmotic stress...
- Selective requirement for SAGA in Hog1-mediated gene expression depending on the severity of the external osmostress conditionsMeritxell Zapater
Cell Signaling Unit, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Dr Aiguader 88, E 08003 Barcelona, Spain
Mol Cell Biol 27:3900-10. 2007....
- [A new approach for better comprehension of diseases of the ocular surface]C Baudouin
Centre National d Ophtalmologie des Quinze Vingts, Paris, France
J Fr Ophtalmol 30:239-46. 2007....
- Saliva indices track hypohydration during 48h of fluid restriction or combined fluid and energy restrictionSamuel J Oliver
School of Sport, Health and Exercise Sciences, Bangor University, Bangor LL57 2PZ, UK
Arch Oral Biol 53:975-80. 2008..Following the 48h periods, UFR and Sosm were assessed after acute exercise dehydration and rehydration...
- Independence of net water flux from paracellular permeability in the intestine of Fundulus heteroclitus, a euryhaline teleostChris M Wood
Rosenstiel School of Marine and Atmospheric Sciences, University of Miami, Miami, FL 33149, USA
J Exp Biol 215:508-17. 2012..We conclude that PEG and water move by separate pathways; absorptive water transport probably occurs via a transcellular route in the intestine of Fundulus heteroclitus...
- Acute hyperosmotic stimulus-induced Fos expression in neurons depends on activation of astrocytes in the supraoptic nucleus of ratsHua Yuan
Institute of Neuroscience, The Fourth Military Medical University, Xi an, China
J Neurosci Res 88:1364-73. 2010..Astrocytes are activated first, whereas connexin 43 functional hemichannels in SON astrocytes are required for the subsequent activation of the neurons...
- Production of piglets after cryopreservation of embryos using a centrifugation-based method for delipation without micromanipulationRongfeng Li
Division of Animal Science, University of Missouri Columbia, Columbia, Missouri, USA
Biol Reprod 80:563-71. 2009..Such high-throughput processing overcomes the lack of high efficiency (i.e., the system can be overloaded with embryos for transfer to surrogates)...
- Phosphorylated Ssk1 prevents unphosphorylated Ssk1 from activating the Ssk2 mitogen-activated protein kinase kinase kinase in the yeast high-osmolarity glycerol osmoregulatory pathwayTetsuro Horie
Institute of Medical Sciences, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Mol Cell Biol 28:5172-83. 2008..Hence, because Ssk1 approximately P binds to and inhibits Ssk1-OH, moderate fluctuation of the level of Ssk1-OH does not lead to nonphysiological and detrimental activation of Hog1...
- The hydration influence on the risk of stroke (THIRST) studyGustavo J Rodriguez
Zeenat Qureshi Stroke Research Center, University of Minnesota, MMC 295, 420 Delaware St SE, Minneapolis, MN 55455, USA
Neurocrit Care 10:187-94. 2009..There is a decreased sensation of thirst and often dehydration among the elderly population. It is unclear whether it represents a contributing factor for cerebral ischemic events...
- Hydration biomarkers and dietary fluid consumption of womenLawrence E Armstrong
Human Performance Laboratory, Department of Kinesiology, University of Connecticut, U 1110, Storrs, CT 06269 1110, USA
J Acad Nutr Diet 112:1056-61. 2012..In conclusion, these data provide objective normative values for hyperhydration, euhydration, and dehydration that can be used by registered dietitians and clinicians to counsel women about their hydration status...
- Influence of progressive fluid restriction on mood and physiological markers of dehydration in womenNathalie Pross
FORENAP, Rouffach, France
Br J Nutr 109:313-21. 2013..Urine specific gravity appears to be the best physiological measure of hydration status in subjects with a normal level of activity; saliva osmolality is another reliable and non-invasive method for assessing hydration status...
- Observations on saliva osmolality during progressive dehydration and partial rehydrationNigel A S Taylor
Centre for Human and Applied Physiology, School of Health Sciences, University of Wollongong, Wollongong, NSW, 2522, Australia
Eur J Appl Physiol 112:3227-37. 2012....
- Predicting the energetics of osmolyte-induced protein folding/unfoldingMatthew Auton
Department of Human Biological Chemistry, University of Texas Medical Branch, 301 University Boulevard, 5 154 Medical Research Building, Galveston, TX 77555 1052, USA
Proc Natl Acad Sci U S A 102:15065-8. 2005..Moreover, the approach permits dissection of the folding/unfolding free-energy changes into individual contributions from the peptide backbone and residue side chains...
- Tear osmolarity in the diagnosis and management of dry eye diseaseMichael A Lemp
Department of Ophthalmology, Georgetown University, Washington, DC, USA
Am J Ophthalmol 151:792-798.e1. 2011..To evaluate the use of tear osmolarity in the diagnosis of dry eye disease...
- Transient activation of the HOG MAPK pathway regulates bimodal gene expressionSerge Pelet
ETH Zurich, Department of Biology, Institute of Biochemistry, Schafmattstrasse 18, CH 8093 Zurich, Switzerland
Science 332:732-5. 2011..Together, these findings provide a molecular mechanism by which a cell can impose a transcriptional threshold in response to a linear signaling behavior...
- Sumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeastYuqi Wang
Department of Biology, Saint Louis University, St Louis, Missouri, United States of America
PLoS ONE 4:e7456. 2009..Taken together, these findings provide evidence for regulated sumoylation as a mechanism to modulate the activity of Tec1 and validate Ubc9 fusion-directed sumoylation as a useful approach for studying protein sumoylation...
- Binding the atypical RA domain of Ste50p to the unfolded Opy2p cytoplasmic tail is essential for the high-osmolarity glycerol pathwayIrena Ekiel
Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada
Mol Biol Cell 20:5117-26. 2009..As well, overall selection of signaling pathways depends on functionally distinct regions of the Ste50p-RA domain, implicating this element in the control of global regulatory decisions...
- An osmosensing signal transduction pathway in yeastJ L Brewster
Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77251
Science 259:1760-3. 1993..These data define a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment...
- Limitations of salivary osmolality as a marker of hydration statusBrett R Ely
US Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
Med Sci Sports Exerc 43:1080-4. 2011..Salivary osmolality (Sosm) is a potentially useful hydration marker but may be confounded by oral artifacts...
- The inner membrane histidine kinase EnvZ senses osmolality via helix-coil transitions in the cytoplasmLoo Chien Wang
Department of Biological Sciences, National University of Singapore, Singapore, Singapore
EMBO J 31:2648-59. 2012..The model provides a conserved mechanism for signalling proteins that respond to diverse physical and mechanical stimuli...
- Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cellsMegan E Cavet
Pharmaceutical R and D, Bausch and Lomb, Inc, Rochester, NY 14609, USA
Mol Vis 16:1791-800. 2010..This study assessed the anti-inflammatory effects of mapracorat in an in vitro osmotic stress model which mimics some of the pathophysiological changes seen in dry eye...
- Hyperosmolarity-mediated mitochondrial dysfunction requires Transglutaminase-2 in human corneal epithelial cellsEvelyn Png
Ocular Wound Healing and Therapeutics Laboratory, Singapore Eye Research Institute, Singapore, Singapore
J Cell Physiol 226:693-9. 2011..This TGM-2-dependent mechanism occurs in part via caspase-3/7 and -9. Protection against mitochondrial stress in the ocular surface targeting TGM-2 may have important implications in the survival of cells in hyperosmolar stress...
- Hyperosmolar stress upregulates HLA-DR expression in human conjunctival epithelium in dry eye patients and in vitro modelsPiera Versura
Ophthalmology Unit, University of Bologna, Bologna, Italy
Invest Ophthalmol Vis Sci 52:5488-96. 2011..To investigate the immune response of human conjunctival epithelium to hyperosmolar stress...
- Hyperosmolarity-induced apoptosis in human corneal epithelial cells is mediated by cytochrome c and MAPK pathwaysLihui Luo
Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA
Cornea 26:452-60. 2007..To study whether hyperosmolarity induces apoptosis in human corneal epithelial cells through cytochrome c-mediated death pathways and by activation of mitogen-activated protein kinases (MAPKs)...
- Decreased aquaporin-2 expression and apical plasma membrane delivery in kidney collecting ducts of polyuric hypercalcemic ratsJ H Earm
Department of Cell Biology, Institute of Anatomy and Institute of Experimental Clinical Research, University of Aarhus, Denmark
J Am Soc Nephrol 9:2181-93. 1998..In summary, the results strongly suggest that AQP2 downregulation and reduced apical plasma membrane delivery of AQP2 play important roles in the development of polyuria in association with hypercalcemia...
- sigmaB-dependent gene induction and expression in Listeria monocytogenes during osmotic and acid stress conditions simulating the intestinal environmentDavid Sue
Department of Food Science, Cornell University, Ithaca, NY 14853, USA
Microbiology 150:3843-55. 2004..As inlA, bsh and opuCA are critical for gastrointestinal infections in animal models, the data also suggest that sigma(B) contributes to the ability of L. monocytogenes to cause foodborne infections...
- Physiological osmotic induction of Leptospira interrogans adhesion: LigA and LigB bind extracellular matrix proteins and fibrinogenHenry A Choy
Division of Infectious Diseases, 111F, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Infect Immun 75:2441-50. 2007..The characterization of the Lig adhesin function should aid the design of Lig-based vaccines and serodiagnostic tests...
- Hyperosmotic stress-induced caspase-3 activation is mediated by p38 MAPK in the hippocampusJulie M Niswander
Department of Neurology, The University of Toledo College of Medicine, Toledo, OH 43614 5809, USA
Brain Res 1186:1-11. 2007....
- A postgenomic appraisal of osmotolerance in Listeria monocytogenesRoy D Sleator
Department of Microbiology and National Food Biotechnology Centre, University College Cork, Cork, Ireland
Appl Environ Microbiol 69:1-9. 2003
- Testing the paradigm that the denaturing effect of urea on protein stability is offset by methylamines at the physiological concentration ratio of 2:1 (urea:methylamines)Laishram Rajendrakumar Singh
Department of Biosciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110 025, India
Biochim Biophys Acta 1774:1555-62. 2007..We show here that the molar concentration of a methylamine required to offset the denaturing effect of urea at a given concentration is different for different proteins...
- The effect of osmotic stress on the cell volume, metaphase II spindle and developmental potential of in vitro matured porcine oocytesS F Mullen
The Comparative Medicine Center and Department of Veterinary Pathobiology, The University of Missouri at Columbia, Columbia, MO 65211, USA
Cryobiology 54:281-9. 2007....
- Association and dissociation kinetics for CheY interacting with the P2 domain of CheARichard C Stewart
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
J Mol Biol 336:287-301. 2004....
- Tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) in mechanically stimulated vascular endothelial cellsM Osawa
Department of Structural Analysis, National Cardiovascular Center Research Institute, Osaka Japan
Eur J Cell Biol 72:229-37. 1997..Our study is the first demonstration of inducible tyrosine phosphorylation of PECAM-1 and suggests involvement of PECAM-1 and Src family kinases in the sensing/signal transduction of mechanical stimuli in ECs...
- Isotonic NaCl intake by cell-dehydrated ratsDaniela T B Pereira
Department of Physiology and Pathology, School of Dentistry, Paulista State University UNESP, Rua Humaita, 1680 Centro, 14801 903, Araraquara, Sao Paulo, Brazil
Physiol Behav 76:501-5. 2002..4; 0.9% NaCl: 0.5+/-0.2 ml/2 h, n=14). Therefore, a sodium load that raises natremia and plasma osmolality, and therefore induces cell dehydration, results in both 0.9% NaCl and water ingestion when the rats have a two-bottle choice...
- Maxi-anion channel as a candidate pathway for osmosensitive ATP release from mouse astrocytes in primary cultureHong Tao Liu
Department of Cell Physiology, National Institute for Physiological Sciences, Myodaiji cho, Okazaki 444 8585, Japan
Cell Res 18:558-65. 2008..Thus, we propose that the maxi-anion channel constitutes a major pathway for swelling-induced ATP release from cultured mouse astrocytes as well...
- Hyperosmolarity-induced cornification of human corneal epithelial cells is regulated by JNK MAPKZhuo Chen
Department of Ophthalmology, The Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030, USA
Invest Ophthalmol Vis Sci 49:539-49. 2008....
- Effect of hyperosmolality on beta-defensin gene expression by human corneal epithelial cellsSrihari Narayanan
College of Optometry, University of Houston, Houston, TX 77204 2020, USA
Cornea 25:1063-8. 2006....
- High urea and creatinine concentrations and urea transporter B in mammalian urinary tract tissuesDavid A Spector
Division of Renal Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Physiol Renal Physiol 292:F467-74. 2007....
- Osmotic stress of salmon stimulates upregulation of a cold inducible RNA binding protein (CIRP) similar to that of mammals and amphibiansFeng Pan
Dept of Fisheries, Animal and Veterinary Science, Building 14 East Farm, URI, Kingston, RI 02881, USA
Biochimie 86:451-61. 2004..In contrast to the function of CIRPs, SGRP appears to have a more prominent role in adaptation to hyperosmotic conditions rather than cold stress...
- When the stress of your environment makes you go HOG wildPatrick J Westfall
Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3202, USA
Science 306:1511-2. 2004..These findings have had direct application to understanding stress sensing and control of transcription by stress-activated mitogen-activated protein kinases in mammalian cells...
- Influence of raised plasma osmolality on clinical outcome after acute strokeA Bhalla
Department of Public Health Sciences, Guy s, King s and St Thomas Hospital School of Medicine, Guy s and St Thomas Hospital, London, England
Stroke 31:2043-8. 2000..We examined the association of raised plasma osmolality on stroke outcome at 3 months and the change of plasma osmolality with hydration during the first week after stroke...
- Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cellsHervør Lykke Olsen
Lilly Research Laboratories, Essener Bogen 7, D 22419 Hamburg, Germany
Endocrinology 146:4861-70. 2005..The stimulatory action of glucose in isolated alpha-cells contrasts with the suppressive effect of the sugar in intact islets and highlights the primary importance of islet paracrine signaling in the regulation of glucagon release...
- Characterization of defined ompR mutants of Salmonella typhi: ompR is involved in the regulation of Vi polysaccharide expressionD Pickard
Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, United Kingdom
Infect Immun 62:3984-93. 1994..typhi and that one of the environmental signals for this regulation may be osmolarity...
- Adaptor functions of Cdc42, Ste50, and Sho1 in the yeast osmoregulatory HOG MAPK pathwayKazuo Tatebayashi
Division of Molecular Cell Signaling, Institute of Medical Sciences, University of Tokyo, Tokyo, Japan
EMBO J 25:3033-44. 2006..Thus, Cdc42, Ste50, and Sho1 act as adaptor proteins that control the flow of the osmostress signal from Ste20/Cla4 to Ste11, then to Pbs2...
- Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1M Trevisani
Department of Experimental and Clinical Medicine, Headache Center, University of Ferrara, via Fossato di Mortara 19, 44100 Ferrara, Italy
Nat Neurosci 5:546-51. 2002..This provides a likely mechanistic explanation for the ethanol-induced sensory responses that occur at body temperature and for the sensitivity of inflamed tissues to ethanol, such as might be found in esophagitis, neuralgia or wounds...
- Mucosal irritation potential of personal lubricants relates to product osmolality as detected by the slug mucosal irritation assayEls Adriaens
Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium
Sex Transm Dis 35:512-6. 2008..In the current study, it was determined whether musosal irritation potency of personal lubricants is related to varying product osmolalities...
- Osmolarity, ionic flux, and changes in brain excitabilityP A Schwartzkroin
Department of Neurological Surgery, University of Washington, Seattle 98195 6470, USA
Epilepsy Res 32:275-85. 1998..These experiments indicate that manipulation of ionic balance may not only facilitate epileptiform activities, but may also provide insight into new therapeutic strategies to block seizures...
- Copeptin in the differential diagnosis of the polydipsia-polyuria syndrome--revisiting the direct and indirect water deprivation testsWiebke Fenske
Department of Internal Medicine I Endocrine Unit, University Hospital Wurzburg, Oberdurrbacher Strasse 6, D 97080 Wurzburg, Germany
J Clin Endocrinol Metab 96:1506-15. 2011..In theory, direct measurement of AVP is highly attractive but is hampered by technical difficulties...
- A link between tear instability and hyperosmolarity in dry eyeHaixia Liu
Indiana University School of Optometry, Bloomington, IN 47401, USA
Invest Ophthalmol Vis Sci 50:3671-9. 2009..The purpose of this study was to provide indirect evidence of short-term hyperosmolar conditions during tear instability and to test whether the corneal epithelium responds to transient hyperosmolar stress...
- Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathwayT Ketela
Department of Biology, McGill University, Montreal, Quebec, Canada H3A 1B1
J Bacteriol 181:3330-40. 1999..In addition, we have identified an open reading frame, MTL1, which encodes a protein with both structural and functional similarity to Mid2p...
- Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulationM J Tamas
Laboratorium voor Moleculaire Celbiologie, Katholieke Universiteit Leuven, Flanders, Belgium
Mol Microbiol 31:1087-104. 1999..Fps1p may be an example of a more widespread class of regulators of osmoadaptation, which control the cellular content and release of compatible solutes...
- YB-1 is capable of forming extended nanofibrilsO M Selivanova
Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia
Biochemistry (Mosc) 75:115-20. 2010..They possess polarity and tend to associate with one another to give structures of a higher order, like ribbons or bundles. The YB-1 fibrillar architecture has a distinct periodicity with a repeat unit of about 52 nm...
- Physiological and biochemical analysis of overwintering and cold tolerance in two Central European populations of the spruce bark beetle, Ips typographusV Kostal
Biology Centre, AS CR, Institute of Entomology, Ceske Budejovice, Czech Republic
J Insect Physiol 57:1136-46. 2011..Lts50 at -15°C are significantly shorter in moist (6.9 days) than in dry (>42 days) microenvironment because there is higher probability of external ice nucleation and occurrence of lethal freezing in the moist situation...
- Transient receptor potential vanilloid 1 is required for intrinsic osmoreception in organum vasculosum lamina terminalis neurons and for normal thirst responses to systemic hyperosmolalitySorana Ciura
Centre for Research in Neuroscience, Montreal General Hospital and McGill University, Montreal, Quebec, Canada, H3G 1A4
J Neurosci 26:9069-75. 2006..These findings indicate that OVLT neurons act as primary osmoreceptors and that a product of the trpv1 gene is required for osmosensory transduction...
- Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stressMarkus Proft
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
Mol Cell 9:1307-17. 2002..Cyc8-Tup1 is not simply a corepressor but is also involved in recruiting SWI/SNF and SAGA during the transcriptional induction process...
- Controlled water intake: a method for objectively evaluating thirst and hydration state in monkeys by the measurement of blood osmolalityHiroshi Yamada
Center for Neural Science, New York University, New York, NY 10003, USA
J Neurosci Methods 191:83-9. 2010..This evidence suggests that osmolality can be used as a tool for monitoring the hydration level of experimental subjects...
- The frequency dependence of osmo-adaptation in Saccharomyces cerevisiaeJerome T Mettetal
Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 319:482-4. 2008..After large osmotic shocks, an additional, much slower, negative feedback through gene expression allows cells to respond faster to future stimuli...
- Osmosensing and osmosignaling in Corynebacterium glutamicumReinhard Kramer
Institute of Biochemistry, University of Cologne, Germany
Amino Acids 37:487-97. 2009..The molecular mechanism of the activation process is discussed in relation to the recently published X-ray structure of BetP...
- The effects of fluid restriction on hydration status and subjective feelings in manSusan M Shirreffs
School of Sport and Exercise Sciences, Loughborough University, Loughborough LE11 3TU, UK
Br J Nutr 91:951-8. 2004..Thirst increased from 0-13 h of FR then did not increase further (P>0.05). The subjects reported feelings of headache during the FR trial and also that their ability to concentrate and their alertness were reduced...
- Hydroxyectoine is superior to trehalose for anhydrobiotic engineering of Pseudomonas putida KT2440M Manzanera
Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT, United Kingdom
Appl Environ Microbiol 68:4328-33. 2002..Hydroxyectoine therefore has considerable potential for the improvement of desiccation tolerance in sensitive microorganisms, particularly for those recalcitrant to trehalose...
- Glucose-mediated induction of TGF-beta 1 and MCP-1 in mesothelial cells in vitro is osmolality and polyol pathway dependentTeresa Y H Wong
Institute of Nephrology, University of Wales College of Medicine, Cardiff, United Kingdom
Kidney Int 63:1404-16. 2003..The contribution of the polyol pathway to mesothelial cell activation has, however, not been fully determined...
- Osmotic demyelination syndrome following rapid correction of hyponatraemiaD M Snell
University Hospital of North Tees, Hardwick Road, Stockton, UK
Anaesthesia 63:92-5. 2008..Continuous veno-venous haemofiltration has been used effectively in this setting...
- Effect of peristaltic contractions of the renal pelvic wall on solute concentrations of the renal inner medulla in the hamsterMary Ella C Pruitt
Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
Am J Physiol Renal Physiol 290:F892-6. 2006..This procedure also significantly decreased inner medullary osmolality. We conclude that elimination of the contractions of the renal pelvic wall in the hamster significantly impairs inner medullary concentrating ability...
- Peak bone mass in patients with phenylketonuriaD Modan-Moses
Pediatric Endocrinology Unit, The Edmond and Lily Safra Children s Hospital, Tel Hashomer, 52621, Israel
J Inherit Metab Dis 30:202-8. 2007..Our aim was to evaluate peak bone mass in adult PKU patients and to relate BMD to nutritional parameters...
- Do vesical and voided urine have identical compositions?Ahmed Shafik
Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Cairo, Egypt
Scand J Urol Nephrol 38:243-6. 2004..In view of the concept that the urothelium is a functioning epithelium, we investigated the hypothesis that the composition of urine is modified as it passes through the urethra from the urinary bladder to the exterior...
- NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironmentWilliam Y Go
Department of Pathology, School of Medicine, University of California at San Diego, La Jolla, CA 92093 0644, USA
Proc Natl Acad Sci U S A 101:10673-8. 2004....
- Aquaporin-2 water channels in spontaneously hypertensive ratsMichele Buemi
Nephrology, Department of Internal Medicine, University of Messina, Messina, Italy
Am J Hypertens 17:1170-8. 2004..The PAVP appeared to be higher in OPC-treated rats from both strains. These findings suggest that AVP and the AQP2 are involved in the pathogenesis of hypertension in SHR...
- Regulatory volume decrease (RVD) by isolated and in situ bovine articular chondrocytesP G Bush
Department of Biomedical Sciences (Physiology, University Medical School, Hugh Robson Building, George Square, Edinburgh, UK
J Cell Physiol 187:304-14. 2001..The results suggested that the signalling pathways involved in RVD remained intact after chondrocyte isolation from cartilage and thus it was likely that there was no role for cell-matrix interactions in mediating RVD...
- Osmotic stress up-regulates aquaporin-3 gene expression in cultured human keratinocytesY Sugiyama
Basic Research Laboratory, Kanebo Ltd, 5-3-28 Kotobuki-cho, 250-0002, Odawara, Japan
Biochim Biophys Acta 1522:82-8. 2001..However, AQP1, AQP4 and AQP9 mRNA expression were unchanged under any of the hypertonic conditions examined. These findings indicated that osmotic stress up-regulates AQP3 gene expression in cultured keratinocytes...
- A novel type of urea transporter, UT-C, is highly expressed in proximal tubule of seawater eel kidneyAbinash Chandra Mistry
Dept of Biological Sciences, Tokyo Institute of Technology, 4259 B 19 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
Am J Physiol Renal Physiol 288:F455-65. 2005....
- Does the composition of voided urine reflect that of the renal pelvis?Ahmed Shafik
Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, 2 Talaat Harb Street, Cairo, 11121, Egypt
Urol Res 34:261-4. 2006..The composition of voided urine does not seem to compare to renal pelvic urine. This concept needs to be considered in urine analysis evaluation and its relation to renal function...
- A nicked duplex decamer DNA with a PEG(6) tetherL Kozerski
Drug Institute, 00 725 Warszawa, Chetmska 30 34, Poland, Institute of Organic Chemistry, Polish Academy of Sciences, 01 224 Warszawa, Kasprzaka 44, Poland
Nucleic Acids Res 29:1132-43. 2001..At the same time the (1)H resonances have longer T:(1) times. This parameter is suggested as a sensitive gauge of stabilisation...
- A sensor for intracellular ionic strengthEsther Biemans-Oldehinkel
Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
Proc Natl Acad Sci U S A 103:10624-9. 2006..We present a model for the gating of membrane transport by ionic strength and propose a new role for CBS domains...
- THERMODYNAMICS OF BIOCHEMICAL SYSTEMSROBERT ALBERTY; Fiscal Year: 2005..This quantitative treatment of the literature data on biochemical reactions will uncover errors because deltafG'0 values can be determined by use of two or more biochemical reactions, which should give the same answer. ..
- Proline uptake in staphylococcus aureus pathogenesisWILLIAM SCHWAN; Fiscal Year: 2002..The results of this study will help us understand the role of proline transport in S. aureus infections. ..
- Multidisciplinary Training Program in Human ImagingGEOFFREY CLARKE; Fiscal Year: 2008..abstract_text> ..
- MECHANISMS OF CELLULAR TAURINE TRANSPORT IN BRAIN EDEMAJames Olson; Fiscal Year: 2001....
- Exposure to Bisphenol A & Reproductive Effect in HumansDe Kun Li; Fiscal Year: 2007..The proposed study will evaluate the reproductive effects of BPA in settings where there have been high levels of exposure. The study will also investigate effects in multiple human generations. ..
- MSM Multiscale Modeling of the Heart in CardiovascularDANIEL BEARD; Fiscal Year: 2007..abstract_text> ..
- GEORGETOWN UNIVERSITY-MEDSTAR CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCEJoseph Verbalis; Fiscal Year: 2006..The planning process will be led by a committee of faculty members who are leaders in translational research and clinical research training at the member institutions. [unreadable] [unreadable] [unreadable]..
- MECHANISMS OF SULFATE TRANSPORT AND REGULATIONMichael Jennings; Fiscal Year: 2007..abstract_text> ..
- Open Tubular Capillary Electrochromatography/Mass SpectroscopyJOSEPH PESEK; Fiscal Year: 2007..This project focuses on providing a means for the analysis of complex samples found in clinical, biological and pharmaceutical applications. [unreadable] [unreadable] [unreadable]..
- Generation of Collecting Duct Knockout of PPARgammaTianxin Yang; Fiscal Year: 2006..New information provided by this proposal is expected to provide insights into the roles of PPARgamma in regulation of fluid balance and in mediation of the side effects of TDZ. ..
- Estrogen & Progesterone Effects on Orthostatic ToleranceNINA STACHENFELD; Fiscal Year: 2010..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
- Improved Measurements of Vocal Fold-Related TissuesSarah Klemuk; Fiscal Year: 2006..Surface roughness of plate and substrate surfaces will be quantified using SEM technology and Scanning Probe Microscopy. [unreadable] [unreadable]..
- Harbor-UCLA Initiative for Minority Student DevelopmentChristina Wang; Fiscal Year: 2005....
- Molecular Physioloy of Brain Cation-Cl CotransportersEric Delpire; Fiscal Year: 2006..abstract_text> ..
- MUSCARINIC RECEPTOR COUPLING TO INOSITIDES IN CNSStephen Fisher; Fiscal Year: 2006..Accordingly, knowledge of the signal transduction pathways that regulate VSOAC is an essential prerequisite for the rational design of therapeutic agents. ..
- Analysis of Large-Scale Biochemical SystemsDANIEL BEARD; Fiscal Year: 2007..In addition, the computational tools that are developed by this research program will be disseminated through a partnership with a software company. [unreadable] [unreadable] [unreadable]..
- Physiologic role of collecting duct ciiliary proteinsDonald Kohan; Fiscal Year: 2007..Most importantly, this work may shed light on novel mechanisms involved in control of blood pressure and development of hypertension. [unreadable] [unreadable] [unreadable]..
- Pressure-enhanced near-infrared breast cancer imagingShudong Jiang; Fiscal Year: 2008....
- HYPONATREMIA-INDUCED OSTEOPOROSISJoseph G Verbalis; Fiscal Year: 2010....
- MECHANISMS OF WATER FLOW ACROSS BIOLOGICAL MEMBRANESMark Zeidel; Fiscal Year: 2009..Building on substantial prior progress, this competing renewal seeks to define at a molecular level the mechanisms by which water and other small molecules cross barrier membranes, AQP's, and UT's. ..
- EGFR Targeted Nanoparticles to Overcome Paclitaxel Resistant Breast CancerRUSSELL MUMPER; Fiscal Year: 2009..The innovation of this proposal relates to nanotemplate engineering of biocompatible nanoparticles, overcoming multi- drug resistance, and the use of nanotechnology to engineer a cell-targeted cancer therapy. ..
- MATHEMATICAL MODELS OF RENAL DYNAMICSHAROLD LAYTON; Fiscal Year: 2009..abstract_text> ..
- Prenatal MF Exposure & Miscarriage Risk Among WomenDe Kun Li; Fiscal Year: 2009..The findings from the proposed study will provide much needed confirmation of the recently reported results and advance our understanding of a MF health effect. ..
- Cerebral edema in pediatric ketoacidosisNicole Glaser; Fiscal Year: 2009..This initial animal data will form the basis for a randomized clinical trial of interventions for the prevention of CE in children with DKA which will be the main focus of the study. ..
- Collecting duct endothelin-1 and hypertensionDonald Kohan; Fiscal Year: 2009..Such information is important in understanding intrarenal mechanisms responsible for hypertension and salt and water retention. ..
- Nanoparticle HIV Protein Vaccines for Cellular ResponsesRUSSELL MUMPER; Fiscal Year: 2009..In addition, Dr. Nath's lab will produce vaccinia expressing antigen. ..
- Cellular Mechanisms Controlling Dog Oocyte MaturationNucharin Songsasen; Fiscal Year: 2008....
- Are IQs low in offspring of euthyroid women with low T4Wendy Craig; Fiscal Year: 2008..It is intended that the study be continued for five more years (total of 10) in order to obtain additional estimates of neuropsychological development in the children at a time when more extensive testing can be performed. ..
- Renal medullary COX-2 in blood pressure controlTianxin Yang; Fiscal Year: 2008..The information resulted from these studies will provide new insight into the molecular mechanism responsible for long-term control of arterial blood pressure. ..
- Interaction of COX-2 AND nNOS in renin secretion (R01)Tianxin Yang; Fiscal Year: 2008..abstract_text> ..
- Modulators of CL-dependent Transport Processes (RMI)Eric Delpire; Fiscal Year: 2005....
- The Contact Lens and Dry Eye StudyJason Nichols; Fiscal Year: 2006..The long-term objective of this research is to contribute to a better understanding of the etiology and risk factors for contact lens-related dry eye so that progress can be made toward its prevention. ..
- REDUCTASE INTERACTIONS GOVERNING AROMATASE ACTIVITIESAlan Conley; Fiscal Year: 2001..abstract_text> ..
- EFFECT OF SHIGATOXIN-1 ON BRAIN ENDOTHELIAL CELLSDonald Kohan; Fiscal Year: 2004....
- The Molecular Basis of Ovarian Testosterone ProductionRobert Rosenfield; Fiscal Year: 2004..The overall goal of this proposal is to understand the factors regulating the production of testosterone in women, particularly in their ovaries. ..
- Assesment of a Chronic Subcutaneous Glucose SensorW Ward; Fiscal Year: 2003..ether-based polymer. We will compare their long term function in studies using rabbits, which will be also be used to ascertain the effect of the growth factors and the real-time data processing. ..
- NANOTEMPLATE ENGINEERING OF CELL-SPECIFIC NANOPARTICLESRUSSELL MUMPER; Fiscal Year: 2003..Ideally, data from these therapeutic studies may help to advance these innovative nanotechnologies toward clinical investigation. ..
- PHYSIOLOGICAL ADAPTATION TO SUSTAINED HYPO-OSMOLALITYJoseph Verbalis; Fiscal Year: 2002..These studies should lead to an elucidation of the cellular mechanisms underlying one of the most basic and intriguing unanswered question about clinically hyponatremic disorders. ..
- Development of Etched Modified CapillariesJOSEPH PESEK; Fiscal Year: 2002..Microsolv Corporation will undertake a marketing plan to distribute the products for use by companies working in the targeted application areas. ..
- Estrogen and the Aging Blood Brain BarrierOAK CHI; Fiscal Year: 2002..The information obtained from our study will be crucially important for the clinical application of estrogen therapy for stroke as well as understanding the pathophysiology of age related cerebrovascular changes. ..
- INDICES OF BIOTIN NUTRITIONDonald Mock; Fiscal Year: 2001..4) Whether biotin deficiency of similar severity to that observed either early or late in human gestation causes increased rates of fetal malformation in the mouse. 5) The enzyme(s) responsible for biotin beta-oxidation. ..
- 3 D HOLOGRAPHIC VIDEO RECORDING IN BIOLOGICAL TISSUEDavid Nolte; Fiscal Year: 2001....
- FREE PLASMA SEX HORMONE AND ANDROGEN ACTIONRobert Rosenfield; Fiscal Year: 2001....
- INDUCED ABORTION AND BREAST CANCER RISKDe Kun Li; Fiscal Year: 2001....
- SHIGA LIKE TOXIN AND RENAL CELL DYSFUNCTIONDonald Kohan; Fiscal Year: 2001..These studies provide essential information on how and why HGEN are damaged in HUS. ..
- Optical Imaging of Seizure Activity in Adult NeocortexDARYL HOCHMAN; Fiscal Year: 2004....
- Mechanisms of renal cell adaptation to hypertonicityDIETMAR KUELTZ; Fiscal Year: 2006..Aim 4: By studying the proteins that are targeted by GADD45 proteins during hypertonic stress in renal inner medullary cells. ..
- MoAbs for the Management of Pancreatic CancerDavid Gold; Fiscal Year: 2005..Finally, a PAM4IL2 fusion protein will be examined for its ability to enhance tumor uptake of a subsequently administered radiolabeled PAM4 antibody. ..
- BRAIN OXYTOCIN AND ETHANOL EFFECT ON INGESTIVE BEHAVIORJoseph Verbalis; Fiscal Year: 2001....
- PRESERVATION OF GENETIC LINES IN A NON MAMMALIAN SYSTEMMary Hagedorn; Fiscal Year: 2005..Most importantly, these somatic changes will not affect the germ line, so they are ideal for genomic banking to maintain important genetic stocks for biomedical and endangered fish research. ..
- Gene Polymorphisms, Preterm Birth, Neonatal Complicatio*Steven Witkin; Fiscal Year: 2005..Identification of genetic factors in mothers or their neonates that influence susceptibility to preterm labor and fetal morbidity in different racial groups will aid in development of improved protocols for monitoring and treatment...
- New Paradigms of P450-mediated Steroids MetabolismAlan Conley; Fiscal Year: 2006..abstract_text> ..
- Passivating Proteins in Implantable Glucose SensorsW Ward; Fiscal Year: 2004..8. A histologic evaluation will be performed to assess the effect of passivating proteins and antibody blocked fibrinogen on the nature of the foreign body capsule. ..
- Prostate Cancer Development & GrowthChristina Wang; Fiscal Year: 2004..The results will provide the important missing link between diet fat and CaP growth and development. ..
- Ninth International Conference on Endothelin (ET-9)Donald Kohan; Fiscal Year: 2005..abstract_text> ..
- EFFECT OF DIABETES AND HYPERTENSION ON ISCHEMIC INJURYStephen Schaffer; Fiscal Year: 2003..Cell culture studies will be complimented by studies using an isolated heart model to test the hypothesis that hypertensive diabetic hearts will be more susceptible to an ischemic insole because of elevated levels of angiotensin. ..
- Nanoengineered HIV-1 Vaccines Based on TatRUSSELL MUMPER; Fiscal Year: 2004..The development of an appropriate nanoparticle-based HIV-1 Tat vaccine will also benefit strategies that may incorporate multiple HIV genes such as Tat, Env, Gag, Pol, and Rev. ..
- OmpR and acid regulation of Escherichia coli fim genesWILLIAM SCHWAN; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- Microbial Fingerprinting Chip and Automated AnalysisDON DALY; Fiscal Year: 2003..Because the method and DNA chip is "universal", it may be applicable for the identification of other microorganism, as demonstrated in our preliminary studies with Salmonella, Xanthomonas and E. coli pathogens. ..
- Prenatal NSAID Use and MiscarriageDe Kun Li; Fiscal Year: 2008..unreadable] [unreadable]..
- Genetics of Angiotensinogen-Mediated Hypertension: Stage, Background & GenderDonald E Kohan; Fiscal Year: 2010..Our goal is to advance the specificity of clinical management and treatment of EH. ..
- Correlation of MRI with Cartilage Mechanical StiffnessMartha Gray; Fiscal Year: 2006..abstract_text> ..
- Reducing Renal TGF-B in Diabetic GlomerulosclerosisMARGO COHEN; Fiscal Year: 2005..abstract_text> ..
- SEX HORMONES AND BODY FLUID REGULATIONNINA STACHENFELD; Fiscal Year: 2003....
- 2007 Cellular Osmoregulation: Sensors, Tranducers & Regulators Gordon Research CoPAUL YANCEY; Fiscal Year: 2007..In all aspects of the conference, the organizers are working to promote the involvement of women, minorities and people with disabilities. [unreadable] [unreadable] [unreadable]..
- Role of COX2 in Medullary Interstitial Cell Survival and FunctionGilbert Moeckel; Fiscal Year: 2008..It is necessary to understand how these cells function in order to design better drugs to treat high blood pressure. [unreadable] [unreadable]..
- CONTROL OF SODIUM INTAKE IN THE HINDLIMB UNWEIGHTED RATJ Cunningham; Fiscal Year: 2005..Additionally, these data may contribute to understanding of health problems associated with an aging population and with cardiovascular disease such as congestive heart failure. ..
- NEURAL REGULATION OF VASOPRESSIN RELEASEJ Thomas Cunningham; Fiscal Year: 2010..Benefits: The results will provide new information regarding the control of vasopressin secretion and how these systems contribute to pathophysiology. ..
- In-Home Prevention of SA risks in Native Teen FamiliesJohn T Walkup; Fiscal Year: 2010....
- Risk for Depression Stress and Neuroendocrine FunctionAUDREY TYRKA; Fiscal Year: 2008..This R01 proposal will entail a prospective longitudinal investigation of the effects of childhood adversity and maternal mood and anxiety disorders on the development of neuroendocrine dysfunction and psychopathology. ..
- Delivery Systems for Precision Brain Cell TargetingScott Banta; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Workshop on Methods for Macromolecular ModelingTamar Schlick; Fiscal Year: 2004....
- Mechanisms of DNA PolymerasesTamar Schlick; Fiscal Year: 2007..Such studies have immediate applications to the diagnostics, and eventually treatment via polymerase inhibitors, of human diseases caused by defective repair of DNA, like various cancers and premature aging. ..