osmolar concentration

Summary

Summary: The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent.

Top Publications

  1. pmc Response of Leptospira interrogans to physiologic osmolarity: relevance in signaling the environment-to-host transition
    James Matsunaga
    Research Service, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Infect Immun 75:2864-74. 2007
  2. pmc GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity glycerol response pathway
    J Albertyn
    Department of Microbiology and Biochemistry, Faculty of Science, University of the Orange Free State, Bloemfontein, South Africa
    Mol Cell Biol 14:4135-44. 1994
  3. pmc Osmosensing by bacteria: signals and membrane-based sensors
    J M Wood
    Department of Microbiology and Guelph Waterloo Centre for Graduate Work in Chemistry, University of Guelph, Guelph, Ontario, Canada N1G
    Microbiol Mol Biol Rev 63:230-62. 1999
  4. ncbi Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease
    H Matsui
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, 27599 7248, USA
    Cell 95:1005-15. 1998
  5. ncbi Human hydration indices: acute and longitudinal reference values
    Lawrence E Armstrong
    Human Performance Laboratory, University of Connecticut, Storrs, CT, USA
    Int J Sport Nutr Exerc Metab 20:145-53. 2010
  6. ncbi Saliva parameters as potential indices of hydration status during acute dehydration
    Neil P Walsh
    School of Sport, Health and Exercise Sciences, University of Wales, Bangor, United Kingdom
    Med Sci Sports Exerc 36:1535-42. 2004
  7. ncbi Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses
    Paul H Yancey
    Biology Department, Whitman College, Walla Walla, WA 99362, USA
    J Exp Biol 208:2819-30. 2005
  8. ncbi Assessing hydration status: the elusive gold standard
    Lawrence E Armstrong
    Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT 06269 1110, USA
    J Am Coll Nutr 26:575S-584S. 2007
  9. ncbi Reference change values for monitoring dehydration
    Samuel N Cheuvront
    U S Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, Natick, MA 01760 5007, USA
    Clin Chem Lab Med 49:1033-7. 2011
  10. ncbi Central mechanisms of osmosensation and systemic osmoregulation
    Charles W Bourque
    Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Room L7 216, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, H3G 1A4, Canada
    Nat Rev Neurosci 9:519-31. 2008

Detail Information

Publications319 found, 100 shown here

  1. pmc Response of Leptospira interrogans to physiologic osmolarity: relevance in signaling the environment-to-host transition
    James Matsunaga
    Research Service, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Infect Immun 75:2864-74. 2007
    ..These findings suggest that physiologic osmolarity is an important signal for regulation of gene expression by pathogenic leptospires during transition from ambient conditions to the host tissue environment...
  2. pmc GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity glycerol response pathway
    J Albertyn
    Department of Microbiology and Biochemistry, Faculty of Science, University of the Orange Free State, Bloemfontein, South Africa
    Mol Cell Biol 14:4135-44. 1994
    ..Thus, the HOG pathway most probably has additional targets in the mechanism of adaptation to hypertonic medium...
  3. pmc Osmosensing by bacteria: signals and membrane-based sensors
    J M Wood
    Department of Microbiology and Guelph Waterloo Centre for Graduate Work in Chemistry, University of Guelph, Guelph, Ontario, Canada N1G
    Microbiol Mol Biol Rev 63:230-62. 1999
    ..Thus, osmoregulatory responses accommodate and exploit the effects of individual cosolvents on cell structure and function as well as the collective contribution of cosolvents to intracellular osmolality...
  4. ncbi Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease
    H Matsui
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, 27599 7248, USA
    Cell 95:1005-15. 1998
    ..These data indicate that therapy for CF lung disease should not be directed at modulation of ionic composition, but rather at restoring volume (salt and water) on airway surfaces...
  5. ncbi Human hydration indices: acute and longitudinal reference values
    Lawrence E Armstrong
    Human Performance Laboratory, University of Connecticut, Storrs, CT, USA
    Int J Sport Nutr Exerc Metab 20:145-53. 2010
    ..These findings provide euhydration reference values and hydration extremes for 7 commonly used indices in free-living, healthy, active men who were not exercising in a hot environment or training strenuously...
  6. ncbi Saliva parameters as potential indices of hydration status during acute dehydration
    Neil P Walsh
    School of Sport, Health and Exercise Sciences, University of Wales, Bangor, United Kingdom
    Med Sci Sports Exerc 36:1535-42. 2004
    ....
  7. ncbi Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses
    Paul H Yancey
    Biology Department, Whitman College, Walla Walla, WA 99362, USA
    J Exp Biol 208:2819-30. 2005
    ..Some of these solutes have applications in biotechnology, agriculture and medicine, including in vitro rescue of the misfolded protein of cystic fibrosis. However, caution is warranted if high levels cause overstabilization of proteins...
  8. ncbi Assessing hydration status: the elusive gold standard
    Lawrence E Armstrong
    Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT 06269 1110, USA
    J Am Coll Nutr 26:575S-584S. 2007
    ....
  9. ncbi Reference change values for monitoring dehydration
    Samuel N Cheuvront
    U S Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, Natick, MA 01760 5007, USA
    Clin Chem Lab Med 49:1033-7. 2011
    ..A secondary purpose was to validate use of the tool by dehydrating a group of volunteers...
  10. ncbi Central mechanisms of osmosensation and systemic osmoregulation
    Charles W Bourque
    Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Room L7 216, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, H3G 1A4, Canada
    Nat Rev Neurosci 9:519-31. 2008
    ..Here, recent advances in our understanding of the molecular, cellular and network mechanisms that mediate the central control of osmotic homeostasis in mammals are reviewed...
  11. pmc Phosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolarity
    Josep Clotet
    Department of Molecular and Cellular Biology, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Spain
    EMBO J 25:2338-46. 2006
    ....
  12. pmc Sphingolipids regulate the yeast high-osmolarity glycerol response pathway
    Mirai Tanigawa
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    Mol Cell Biol 32:2861-70. 2012
    ..These observations reveal the sphingolipid-mediated regulation of the osmosensing machinery of the HOG pathway...
  13. pmc The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae
    S M O'Rourke
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143 0448, USA
    Genes Dev 12:2874-86. 1998
    ..Finally, we have found that pseudohyphal growth exhibited by wild-type (HOG1) strains depends on SHO1, suggesting that Sho1p may be a receptor that feeds into the pseudohyphal growth pathway...
  14. ncbi Dehydration in hospital-admitted stroke patients: detection, frequency, and association
    Anne Rowat
    Edinburgh Napier University, School of Nursing and Midwifery and Social Care, Edinburgh, Scotland
    Stroke 43:857-9. 2012
    ..We aimed to determine the frequency of dehydration, risk factors, and associations with outcomes at hospital discharge after stroke...
  15. pmc Identification and characterization of OscR, a transcriptional regulator involved in osmolarity adaptation in Vibrio cholerae
    Nicholas J Shikuma
    Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California 95064, USA
    J Bacteriol 191:4082-96. 2009
    ..oscR mutants were less motile and exhibited enhanced biofilm formation only under low-salt conditions...
  16. pmc Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases
    S M Wurgler-Murphy
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Mol Cell Biol 17:1289-97. 1997
    ..Thus, the kinase activity of Hog1p is required for its own tyrosine dephosphorylation. Northern blot analyses suggest that Hog1p regulates Ptp2p and/or Ptp3p activity at the posttranscriptional level...
  17. ncbi Sorption of 243Am(III) to multiwall carbon nanotubes
    Xiangke Wang
    Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, People s Republic of China
    Environ Sci Technol 39:2856-60. 2005
    ....
  18. pmc Osmoregulation of taurine transporter function and expression in retinal pigment epithelial, ganglion, and müller cells
    Amira El-Sherbeny
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912 2000, USA
    Invest Ophthalmol Vis Sci 45:694-701. 2004
    ..To determine whether taurine transporter (TauT) activity and expression are regulated by hyperosmolarity in RPE, ganglion, and Müller cells...
  19. ncbi Hyperosmolality causes growth arrest of murine kidney cells. Induction of GADD45 and GADD153 by osmosensing via stress-activated protein kinase 2
    D Kultz
    Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    J Biol Chem 273:13645-51. 1998
    ....
  20. ncbi Assessing hydration status
    Stavros A Kavouras
    Laboratory of Nutrition and Clinical Dietetics, Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
    Curr Opin Clin Nutr Metab Care 5:519-24. 2002
    ..Understanding the importance of euhydration in humans in order to ensure good health in various situations, the purpose of this review is to examine the available techniques in assessing hydration status...
  21. ncbi Effect of water deprivation on cognitive-motor performance in healthy men and women
    Gabor Szinnai
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine, University Hospital, CH 4031 Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 289:R275-80. 2005
    ..Increased subjective task-related effort suggests that healthy volunteers exhibit cognitive compensating mechanisms for increased tiredness and reduced alertness during slowly progressive moderate dehydration...
  22. ncbi Removal of Pb(II) from aqueous solution by oxidized multiwalled carbon nanotubes
    Di Xu
    Institute of Plasma Physics, Chinese Academy of Sciences, P O Box 1126, 230031 Hefei, China
    J Hazard Mater 154:407-16. 2008
    ....
  23. ncbi Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels
    T Ma
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 273:4296-9. 1998
    ..The results suggest that AQP1 knockout mice are unable to create a hypertonic medullary interstitium by countercurrent multiplication. AQP1 is thus required for the formation of a concentrated urine by the kidney...
  24. pmc Reciprocal regulation of plasma apelin and vasopressin by osmotic stimuli
    Michel Azizi
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Universite Paris Descartes, Faculte de Medecine, and INSERM, CIC 9201, Paris, France
    J Am Soc Nephrol 19:1015-24. 2008
  25. ncbi Conditions for the triggering of spreading depression studied with computer simulations
    H Kager
    Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    J Neurophysiol 88:2700-12. 2002
    ....
  26. pmc The RA domain of Ste50 adaptor protein is required for delivery of Ste11 to the plasma membrane in the filamentous growth signaling pathway of the yeast Saccharomyces cerevisiae
    Dagmar M Truckses
    Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Room 16, Barker Hall, Berkeley, CA 94720 3202, USA
    Mol Cell Biol 26:912-28. 2006
    ..Thus, Ste50 serves as an adaptor to tether Ste11 to the plasma membrane and can do so via association with Cdc42, thereby permitting the encounter of Ste11 with activated Ste20...
  27. ncbi Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells
    De Quan Li
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA
    Invest Ophthalmol Vis Sci 45:4302-11. 2004
    ....
  28. pmc Time-dependent proteome alterations under osmotic stress during aerobic and anaerobic growth in Escherichia coli
    Arnim Weber
    Ludwig Maximilians Universitat Munchen, Department Biologie I, Bereich Mikrobiologie, Maria Ward Str 1a, D 80638 München, Germany
    J Bacteriol 188:7165-75. 2006
    ..Only a few proteins were found to be down-regulated upon osmotic stress...
  29. pmc Selective requirement for SAGA in Hog1-mediated gene expression depending on the severity of the external osmostress conditions
    Meritxell Zapater
    Cell Signaling Unit, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Dr Aiguader 88, E 08003 Barcelona, Spain
    Mol Cell Biol 27:3900-10. 2007
    ....
  30. ncbi [A new approach for better comprehension of diseases of the ocular surface]
    C Baudouin
    Centre National d Ophtalmologie des Quinze Vingts, Paris, France
    J Fr Ophtalmol 30:239-46. 2007
    ....
  31. ncbi Saliva indices track hypohydration during 48h of fluid restriction or combined fluid and energy restriction
    Samuel J Oliver
    School of Sport, Health and Exercise Sciences, Bangor University, Bangor LL57 2PZ, UK
    Arch Oral Biol 53:975-80. 2008
    ..Following the 48h periods, UFR and Sosm were assessed after acute exercise dehydration and rehydration...
  32. ncbi Independence of net water flux from paracellular permeability in the intestine of Fundulus heteroclitus, a euryhaline teleost
    Chris M Wood
    Rosenstiel School of Marine and Atmospheric Sciences, University of Miami, Miami, FL 33149, USA
    J Exp Biol 215:508-17. 2012
    ..We conclude that PEG and water move by separate pathways; absorptive water transport probably occurs via a transcellular route in the intestine of Fundulus heteroclitus...
  33. ncbi Acute hyperosmotic stimulus-induced Fos expression in neurons depends on activation of astrocytes in the supraoptic nucleus of rats
    Hua Yuan
    Institute of Neuroscience, The Fourth Military Medical University, Xi an, China
    J Neurosci Res 88:1364-73. 2010
    ..Astrocytes are activated first, whereas connexin 43 functional hemichannels in SON astrocytes are required for the subsequent activation of the neurons...
  34. pmc Production of piglets after cryopreservation of embryos using a centrifugation-based method for delipation without micromanipulation
    Rongfeng Li
    Division of Animal Science, University of Missouri Columbia, Columbia, Missouri, USA
    Biol Reprod 80:563-71. 2009
    ..Such high-throughput processing overcomes the lack of high efficiency (i.e., the system can be overloaded with embryos for transfer to surrogates)...
  35. pmc Phosphorylated Ssk1 prevents unphosphorylated Ssk1 from activating the Ssk2 mitogen-activated protein kinase kinase kinase in the yeast high-osmolarity glycerol osmoregulatory pathway
    Tetsuro Horie
    Institute of Medical Sciences, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Mol Cell Biol 28:5172-83. 2008
    ..Hence, because Ssk1 approximately P binds to and inhibits Ssk1-OH, moderate fluctuation of the level of Ssk1-OH does not lead to nonphysiological and detrimental activation of Hog1...
  36. ncbi The hydration influence on the risk of stroke (THIRST) study
    Gustavo J Rodriguez
    Zeenat Qureshi Stroke Research Center, University of Minnesota, MMC 295, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Neurocrit Care 10:187-94. 2009
    ..There is a decreased sensation of thirst and often dehydration among the elderly population. It is unclear whether it represents a contributing factor for cerebral ischemic events...
  37. ncbi Hydration biomarkers and dietary fluid consumption of women
    Lawrence E Armstrong
    Human Performance Laboratory, Department of Kinesiology, University of Connecticut, U 1110, Storrs, CT 06269 1110, USA
    J Acad Nutr Diet 112:1056-61. 2012
    ..In conclusion, these data provide objective normative values for hyperhydration, euhydration, and dehydration that can be used by registered dietitians and clinicians to counsel women about their hydration status...
  38. pmc Influence of progressive fluid restriction on mood and physiological markers of dehydration in women
    Nathalie Pross
    FORENAP, Rouffach, France
    Br J Nutr 109:313-21. 2013
    ..Urine specific gravity appears to be the best physiological measure of hydration status in subjects with a normal level of activity; saliva osmolality is another reliable and non-invasive method for assessing hydration status...
  39. ncbi Observations on saliva osmolality during progressive dehydration and partial rehydration
    Nigel A S Taylor
    Centre for Human and Applied Physiology, School of Health Sciences, University of Wollongong, Wollongong, NSW, 2522, Australia
    Eur J Appl Physiol 112:3227-37. 2012
    ....
  40. pmc Predicting the energetics of osmolyte-induced protein folding/unfolding
    Matthew Auton
    Department of Human Biological Chemistry, University of Texas Medical Branch, 301 University Boulevard, 5 154 Medical Research Building, Galveston, TX 77555 1052, USA
    Proc Natl Acad Sci U S A 102:15065-8. 2005
    ..Moreover, the approach permits dissection of the folding/unfolding free-energy changes into individual contributions from the peptide backbone and residue side chains...
  41. ncbi Tear osmolarity in the diagnosis and management of dry eye disease
    Michael A Lemp
    Department of Ophthalmology, Georgetown University, Washington, DC, USA
    Am J Ophthalmol 151:792-798.e1. 2011
    ..To evaluate the use of tear osmolarity in the diagnosis of dry eye disease...
  42. ncbi Transient activation of the HOG MAPK pathway regulates bimodal gene expression
    Serge Pelet
    ETH Zurich, Department of Biology, Institute of Biochemistry, Schafmattstrasse 18, CH 8093 Zurich, Switzerland
    Science 332:732-5. 2011
    ..Together, these findings provide a molecular mechanism by which a cell can impose a transcriptional threshold in response to a linear signaling behavior...
  43. pmc Sumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeast
    Yuqi Wang
    Department of Biology, Saint Louis University, St Louis, Missouri, United States of America
    PLoS ONE 4:e7456. 2009
    ..Taken together, these findings provide evidence for regulated sumoylation as a mechanism to modulate the activity of Tec1 and validate Ubc9 fusion-directed sumoylation as a useful approach for studying protein sumoylation...
  44. pmc Binding the atypical RA domain of Ste50p to the unfolded Opy2p cytoplasmic tail is essential for the high-osmolarity glycerol pathway
    Irena Ekiel
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada
    Mol Biol Cell 20:5117-26. 2009
    ..As well, overall selection of signaling pathways depends on functionally distinct regions of the Ste50p-RA domain, implicating this element in the control of global regulatory decisions...
  45. ncbi An osmosensing signal transduction pathway in yeast
    J L Brewster
    Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77251
    Science 259:1760-3. 1993
    ..These data define a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment...
  46. ncbi Limitations of salivary osmolality as a marker of hydration status
    Brett R Ely
    US Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
    Med Sci Sports Exerc 43:1080-4. 2011
    ..Salivary osmolality (Sosm) is a potentially useful hydration marker but may be confounded by oral artifacts...
  47. pmc The inner membrane histidine kinase EnvZ senses osmolality via helix-coil transitions in the cytoplasm
    Loo Chien Wang
    Department of Biological Sciences, National University of Singapore, Singapore, Singapore
    EMBO J 31:2648-59. 2012
    ..The model provides a conserved mechanism for signalling proteins that respond to diverse physical and mechanical stimuli...
  48. pmc Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cells
    Megan E Cavet
    Pharmaceutical R and D, Bausch and Lomb, Inc, Rochester, NY 14609, USA
    Mol Vis 16:1791-800. 2010
    ..This study assessed the anti-inflammatory effects of mapracorat in an in vitro osmotic stress model which mimics some of the pathophysiological changes seen in dry eye...
  49. ncbi Hyperosmolarity-mediated mitochondrial dysfunction requires Transglutaminase-2 in human corneal epithelial cells
    Evelyn Png
    Ocular Wound Healing and Therapeutics Laboratory, Singapore Eye Research Institute, Singapore, Singapore
    J Cell Physiol 226:693-9. 2011
    ..This TGM-2-dependent mechanism occurs in part via caspase-3/7 and -9. Protection against mitochondrial stress in the ocular surface targeting TGM-2 may have important implications in the survival of cells in hyperosmolar stress...
  50. ncbi Hyperosmolar stress upregulates HLA-DR expression in human conjunctival epithelium in dry eye patients and in vitro models
    Piera Versura
    Ophthalmology Unit, University of Bologna, Bologna, Italy
    Invest Ophthalmol Vis Sci 52:5488-96. 2011
    ..To investigate the immune response of human conjunctival epithelium to hyperosmolar stress...
  51. ncbi Hyperosmolarity-induced apoptosis in human corneal epithelial cells is mediated by cytochrome c and MAPK pathways
    Lihui Luo
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA
    Cornea 26:452-60. 2007
    ..To study whether hyperosmolarity induces apoptosis in human corneal epithelial cells through cytochrome c-mediated death pathways and by activation of mitogen-activated protein kinases (MAPKs)...
  52. ncbi Decreased aquaporin-2 expression and apical plasma membrane delivery in kidney collecting ducts of polyuric hypercalcemic rats
    J H Earm
    Department of Cell Biology, Institute of Anatomy and Institute of Experimental Clinical Research, University of Aarhus, Denmark
    J Am Soc Nephrol 9:2181-93. 1998
    ..In summary, the results strongly suggest that AQP2 downregulation and reduced apical plasma membrane delivery of AQP2 play important roles in the development of polyuria in association with hypercalcemia...
  53. ncbi sigmaB-dependent gene induction and expression in Listeria monocytogenes during osmotic and acid stress conditions simulating the intestinal environment
    David Sue
    Department of Food Science, Cornell University, Ithaca, NY 14853, USA
    Microbiology 150:3843-55. 2004
    ..As inlA, bsh and opuCA are critical for gastrointestinal infections in animal models, the data also suggest that sigma(B) contributes to the ability of L. monocytogenes to cause foodborne infections...
  54. pmc Physiological osmotic induction of Leptospira interrogans adhesion: LigA and LigB bind extracellular matrix proteins and fibrinogen
    Henry A Choy
    Division of Infectious Diseases, 111F, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Infect Immun 75:2441-50. 2007
    ..The characterization of the Lig adhesin function should aid the design of Lig-based vaccines and serodiagnostic tests...
  55. ncbi Hyperosmotic stress-induced caspase-3 activation is mediated by p38 MAPK in the hippocampus
    Julie M Niswander
    Department of Neurology, The University of Toledo College of Medicine, Toledo, OH 43614 5809, USA
    Brain Res 1186:1-11. 2007
    ....
  56. pmc A postgenomic appraisal of osmotolerance in Listeria monocytogenes
    Roy D Sleator
    Department of Microbiology and National Food Biotechnology Centre, University College Cork, Cork, Ireland
    Appl Environ Microbiol 69:1-9. 2003
  57. ncbi Testing the paradigm that the denaturing effect of urea on protein stability is offset by methylamines at the physiological concentration ratio of 2:1 (urea:methylamines)
    Laishram Rajendrakumar Singh
    Department of Biosciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110 025, India
    Biochim Biophys Acta 1774:1555-62. 2007
    ..We show here that the molar concentration of a methylamine required to offset the denaturing effect of urea at a given concentration is different for different proteins...
  58. pmc The effect of osmotic stress on the cell volume, metaphase II spindle and developmental potential of in vitro matured porcine oocytes
    S F Mullen
    The Comparative Medicine Center and Department of Veterinary Pathobiology, The University of Missouri at Columbia, Columbia, MO 65211, USA
    Cryobiology 54:281-9. 2007
    ....
  59. ncbi Association and dissociation kinetics for CheY interacting with the P2 domain of CheA
    Richard C Stewart
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Mol Biol 336:287-301. 2004
    ....
  60. ncbi Tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) in mechanically stimulated vascular endothelial cells
    M Osawa
    Department of Structural Analysis, National Cardiovascular Center Research Institute, Osaka Japan
    Eur J Cell Biol 72:229-37. 1997
    ..Our study is the first demonstration of inducible tyrosine phosphorylation of PECAM-1 and suggests involvement of PECAM-1 and Src family kinases in the sensing/signal transduction of mechanical stimuli in ECs...
  61. ncbi Isotonic NaCl intake by cell-dehydrated rats
    Daniela T B Pereira
    Department of Physiology and Pathology, School of Dentistry, Paulista State University UNESP, Rua Humaita, 1680 Centro, 14801 903, Araraquara, Sao Paulo, Brazil
    Physiol Behav 76:501-5. 2002
    ..4; 0.9% NaCl: 0.5+/-0.2 ml/2 h, n=14). Therefore, a sodium load that raises natremia and plasma osmolality, and therefore induces cell dehydration, results in both 0.9% NaCl and water ingestion when the rats have a two-bottle choice...
  62. ncbi Maxi-anion channel as a candidate pathway for osmosensitive ATP release from mouse astrocytes in primary culture
    Hong Tao Liu
    Department of Cell Physiology, National Institute for Physiological Sciences, Myodaiji cho, Okazaki 444 8585, Japan
    Cell Res 18:558-65. 2008
    ..Thus, we propose that the maxi-anion channel constitutes a major pathway for swelling-induced ATP release from cultured mouse astrocytes as well...
  63. ncbi Hyperosmolarity-induced cornification of human corneal epithelial cells is regulated by JNK MAPK
    Zhuo Chen
    Department of Ophthalmology, The Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Invest Ophthalmol Vis Sci 49:539-49. 2008
    ....
  64. pmc Effect of hyperosmolality on beta-defensin gene expression by human corneal epithelial cells
    Srihari Narayanan
    College of Optometry, University of Houston, Houston, TX 77204 2020, USA
    Cornea 25:1063-8. 2006
    ....
  65. ncbi High urea and creatinine concentrations and urea transporter B in mammalian urinary tract tissues
    David A Spector
    Division of Renal Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Physiol Renal Physiol 292:F467-74. 2007
    ....
  66. ncbi Osmotic stress of salmon stimulates upregulation of a cold inducible RNA binding protein (CIRP) similar to that of mammals and amphibians
    Feng Pan
    Dept of Fisheries, Animal and Veterinary Science, Building 14 East Farm, URI, Kingston, RI 02881, USA
    Biochimie 86:451-61. 2004
    ..In contrast to the function of CIRPs, SGRP appears to have a more prominent role in adaptation to hyperosmotic conditions rather than cold stress...
  67. ncbi When the stress of your environment makes you go HOG wild
    Patrick J Westfall
    Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3202, USA
    Science 306:1511-2. 2004
    ..These findings have had direct application to understanding stress sensing and control of transcription by stress-activated mitogen-activated protein kinases in mammalian cells...
  68. ncbi Influence of raised plasma osmolality on clinical outcome after acute stroke
    A Bhalla
    Department of Public Health Sciences, Guy s, King s and St Thomas Hospital School of Medicine, Guy s and St Thomas Hospital, London, England
    Stroke 31:2043-8. 2000
    ..We examined the association of raised plasma osmolality on stroke outcome at 3 months and the change of plasma osmolality with hydration during the first week after stroke...
  69. ncbi Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells
    Hervør Lykke Olsen
    Lilly Research Laboratories, Essener Bogen 7, D 22419 Hamburg, Germany
    Endocrinology 146:4861-70. 2005
    ..The stimulatory action of glucose in isolated alpha-cells contrasts with the suppressive effect of the sugar in intact islets and highlights the primary importance of islet paracrine signaling in the regulation of glucagon release...
  70. pmc Characterization of defined ompR mutants of Salmonella typhi: ompR is involved in the regulation of Vi polysaccharide expression
    D Pickard
    Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, United Kingdom
    Infect Immun 62:3984-93. 1994
    ..typhi and that one of the environmental signals for this regulation may be osmolarity...
  71. pmc Adaptor functions of Cdc42, Ste50, and Sho1 in the yeast osmoregulatory HOG MAPK pathway
    Kazuo Tatebayashi
    Division of Molecular Cell Signaling, Institute of Medical Sciences, University of Tokyo, Tokyo, Japan
    EMBO J 25:3033-44. 2006
    ..Thus, Cdc42, Ste50, and Sho1 act as adaptor proteins that control the flow of the osmostress signal from Ste20/Cla4 to Ste11, then to Pbs2...
  72. ncbi Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1
    M Trevisani
    Department of Experimental and Clinical Medicine, Headache Center, University of Ferrara, via Fossato di Mortara 19, 44100 Ferrara, Italy
    Nat Neurosci 5:546-51. 2002
    ..This provides a likely mechanistic explanation for the ethanol-induced sensory responses that occur at body temperature and for the sensitivity of inflamed tissues to ethanol, such as might be found in esophagitis, neuralgia or wounds...
  73. ncbi Mucosal irritation potential of personal lubricants relates to product osmolality as detected by the slug mucosal irritation assay
    Els Adriaens
    Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium
    Sex Transm Dis 35:512-6. 2008
    ..In the current study, it was determined whether musosal irritation potency of personal lubricants is related to varying product osmolalities...
  74. ncbi Osmolarity, ionic flux, and changes in brain excitability
    P A Schwartzkroin
    Department of Neurological Surgery, University of Washington, Seattle 98195 6470, USA
    Epilepsy Res 32:275-85. 1998
    ..These experiments indicate that manipulation of ionic balance may not only facilitate epileptiform activities, but may also provide insight into new therapeutic strategies to block seizures...
  75. ncbi Copeptin in the differential diagnosis of the polydipsia-polyuria syndrome--revisiting the direct and indirect water deprivation tests
    Wiebke Fenske
    Department of Internal Medicine I Endocrine Unit, University Hospital Wurzburg, Oberdurrbacher Strasse 6, D 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 96:1506-15. 2011
    ..In theory, direct measurement of AVP is highly attractive but is hampered by technical difficulties...
  76. ncbi A link between tear instability and hyperosmolarity in dry eye
    Haixia Liu
    Indiana University School of Optometry, Bloomington, IN 47401, USA
    Invest Ophthalmol Vis Sci 50:3671-9. 2009
    ..The purpose of this study was to provide indirect evidence of short-term hyperosmolar conditions during tear instability and to test whether the corneal epithelium responds to transient hyperosmolar stress...
  77. pmc Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway
    T Ketela
    Department of Biology, McGill University, Montreal, Quebec, Canada H3A 1B1
    J Bacteriol 181:3330-40. 1999
    ..In addition, we have identified an open reading frame, MTL1, which encodes a protein with both structural and functional similarity to Mid2p...
  78. ncbi Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation
    M J Tamas
    Laboratorium voor Moleculaire Celbiologie, Katholieke Universiteit Leuven, Flanders, Belgium
    Mol Microbiol 31:1087-104. 1999
    ..Fps1p may be an example of a more widespread class of regulators of osmoadaptation, which control the cellular content and release of compatible solutes...
  79. ncbi YB-1 is capable of forming extended nanofibrils
    O M Selivanova
    Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia
    Biochemistry (Mosc) 75:115-20. 2010
    ..They possess polarity and tend to associate with one another to give structures of a higher order, like ribbons or bundles. The YB-1 fibrillar architecture has a distinct periodicity with a repeat unit of about 52 nm...
  80. ncbi Physiological and biochemical analysis of overwintering and cold tolerance in two Central European populations of the spruce bark beetle, Ips typographus
    V Kostal
    Biology Centre, AS CR, Institute of Entomology, Ceske Budejovice, Czech Republic
    J Insect Physiol 57:1136-46. 2011
    ..Lts50 at -15°C are significantly shorter in moist (6.9 days) than in dry (>42 days) microenvironment because there is higher probability of external ice nucleation and occurrence of lethal freezing in the moist situation...
  81. ncbi Transient receptor potential vanilloid 1 is required for intrinsic osmoreception in organum vasculosum lamina terminalis neurons and for normal thirst responses to systemic hyperosmolality
    Sorana Ciura
    Centre for Research in Neuroscience, Montreal General Hospital and McGill University, Montreal, Quebec, Canada, H3G 1A4
    J Neurosci 26:9069-75. 2006
    ..These findings indicate that OVLT neurons act as primary osmoreceptors and that a product of the trpv1 gene is required for osmosensory transduction...
  82. ncbi Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress
    Markus Proft
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 9:1307-17. 2002
    ..Cyc8-Tup1 is not simply a corepressor but is also involved in recruiting SWI/SNF and SAGA during the transcriptional induction process...
  83. pmc Controlled water intake: a method for objectively evaluating thirst and hydration state in monkeys by the measurement of blood osmolality
    Hiroshi Yamada
    Center for Neural Science, New York University, New York, NY 10003, USA
    J Neurosci Methods 191:83-9. 2010
    ..This evidence suggests that osmolality can be used as a tool for monitoring the hydration level of experimental subjects...
  84. pmc The frequency dependence of osmo-adaptation in Saccharomyces cerevisiae
    Jerome T Mettetal
    Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 319:482-4. 2008
    ..After large osmotic shocks, an additional, much slower, negative feedback through gene expression allows cells to respond faster to future stimuli...
  85. ncbi Osmosensing and osmosignaling in Corynebacterium glutamicum
    Reinhard Kramer
    Institute of Biochemistry, University of Cologne, Germany
    Amino Acids 37:487-97. 2009
    ..The molecular mechanism of the activation process is discussed in relation to the recently published X-ray structure of BetP...
  86. ncbi The effects of fluid restriction on hydration status and subjective feelings in man
    Susan M Shirreffs
    School of Sport and Exercise Sciences, Loughborough University, Loughborough LE11 3TU, UK
    Br J Nutr 91:951-8. 2004
    ..Thirst increased from 0-13 h of FR then did not increase further (P>0.05). The subjects reported feelings of headache during the FR trial and also that their ability to concentrate and their alertness were reduced...
  87. pmc Hydroxyectoine is superior to trehalose for anhydrobiotic engineering of Pseudomonas putida KT2440
    M Manzanera
    Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT, United Kingdom
    Appl Environ Microbiol 68:4328-33. 2002
    ..Hydroxyectoine therefore has considerable potential for the improvement of desiccation tolerance in sensitive microorganisms, particularly for those recalcitrant to trehalose...
  88. ncbi Glucose-mediated induction of TGF-beta 1 and MCP-1 in mesothelial cells in vitro is osmolality and polyol pathway dependent
    Teresa Y H Wong
    Institute of Nephrology, University of Wales College of Medicine, Cardiff, United Kingdom
    Kidney Int 63:1404-16. 2003
    ..The contribution of the polyol pathway to mesothelial cell activation has, however, not been fully determined...
  89. ncbi Osmotic demyelination syndrome following rapid correction of hyponatraemia
    D M Snell
    University Hospital of North Tees, Hardwick Road, Stockton, UK
    Anaesthesia 63:92-5. 2008
    ..Continuous veno-venous haemofiltration has been used effectively in this setting...
  90. pmc Effect of peristaltic contractions of the renal pelvic wall on solute concentrations of the renal inner medulla in the hamster
    Mary Ella C Pruitt
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    Am J Physiol Renal Physiol 290:F892-6. 2006
    ..This procedure also significantly decreased inner medullary osmolality. We conclude that elimination of the contractions of the renal pelvic wall in the hamster significantly impairs inner medullary concentrating ability...
  91. ncbi Peak bone mass in patients with phenylketonuria
    D Modan-Moses
    Pediatric Endocrinology Unit, The Edmond and Lily Safra Children s Hospital, Tel Hashomer, 52621, Israel
    J Inherit Metab Dis 30:202-8. 2007
    ..Our aim was to evaluate peak bone mass in adult PKU patients and to relate BMD to nutritional parameters...
  92. ncbi Do vesical and voided urine have identical compositions?
    Ahmed Shafik
    Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Cairo, Egypt
    Scand J Urol Nephrol 38:243-6. 2004
    ..In view of the concept that the urothelium is a functioning epithelium, we investigated the hypothesis that the composition of urine is modified as it passes through the urethra from the urinary bladder to the exterior...
  93. pmc NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment
    William Y Go
    Department of Pathology, School of Medicine, University of California at San Diego, La Jolla, CA 92093 0644, USA
    Proc Natl Acad Sci U S A 101:10673-8. 2004
    ....
  94. ncbi Aquaporin-2 water channels in spontaneously hypertensive rats
    Michele Buemi
    Nephrology, Department of Internal Medicine, University of Messina, Messina, Italy
    Am J Hypertens 17:1170-8. 2004
    ..The PAVP appeared to be higher in OPC-treated rats from both strains. These findings suggest that AVP and the AQP2 are involved in the pathogenesis of hypertension in SHR...
  95. ncbi Regulatory volume decrease (RVD) by isolated and in situ bovine articular chondrocytes
    P G Bush
    Department of Biomedical Sciences (Physiology, University Medical School, Hugh Robson Building, George Square, Edinburgh, UK
    J Cell Physiol 187:304-14. 2001
    ..The results suggested that the signalling pathways involved in RVD remained intact after chondrocyte isolation from cartilage and thus it was likely that there was no role for cell-matrix interactions in mediating RVD...
  96. ncbi Osmotic stress up-regulates aquaporin-3 gene expression in cultured human keratinocytes
    Y Sugiyama
    Basic Research Laboratory, Kanebo Ltd, 5-3-28 Kotobuki-cho, 250-0002, Odawara, Japan
    Biochim Biophys Acta 1522:82-8. 2001
    ..However, AQP1, AQP4 and AQP9 mRNA expression were unchanged under any of the hypertonic conditions examined. These findings indicated that osmotic stress up-regulates AQP3 gene expression in cultured keratinocytes...
  97. ncbi A novel type of urea transporter, UT-C, is highly expressed in proximal tubule of seawater eel kidney
    Abinash Chandra Mistry
    Dept of Biological Sciences, Tokyo Institute of Technology, 4259 B 19 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    Am J Physiol Renal Physiol 288:F455-65. 2005
    ....
  98. ncbi Does the composition of voided urine reflect that of the renal pelvis?
    Ahmed Shafik
    Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, 2 Talaat Harb Street, Cairo, 11121, Egypt
    Urol Res 34:261-4. 2006
    ..The composition of voided urine does not seem to compare to renal pelvic urine. This concept needs to be considered in urine analysis evaluation and its relation to renal function...
  99. pmc A nicked duplex decamer DNA with a PEG(6) tether
    L Kozerski
    Drug Institute, 00 725 Warszawa, Chetmska 30 34, Poland, Institute of Organic Chemistry, Polish Academy of Sciences, 01 224 Warszawa, Kasprzaka 44, Poland
    Nucleic Acids Res 29:1132-43. 2001
    ..At the same time the (1)H resonances have longer T:(1) times. This parameter is suggested as a sensitive gauge of stabilisation...
  100. pmc A sensor for intracellular ionic strength
    Esther Biemans-Oldehinkel
    Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    Proc Natl Acad Sci U S A 103:10624-9. 2006
    ..We present a model for the gating of membrane transport by ionic strength and propose a new role for CBS domains...

Research Grants74

  1. THERMODYNAMICS OF BIOCHEMICAL SYSTEMS
    ROBERT ALBERTY; Fiscal Year: 2005
    ..This quantitative treatment of the literature data on biochemical reactions will uncover errors because deltafG'0 values can be determined by use of two or more biochemical reactions, which should give the same answer. ..
  2. Proline uptake in staphylococcus aureus pathogenesis
    WILLIAM SCHWAN; Fiscal Year: 2002
    ..The results of this study will help us understand the role of proline transport in S. aureus infections. ..
  3. Multidisciplinary Training Program in Human Imaging
    GEOFFREY CLARKE; Fiscal Year: 2008
    ..abstract_text> ..
  4. MECHANISMS OF CELLULAR TAURINE TRANSPORT IN BRAIN EDEMA
    James Olson; Fiscal Year: 2001
    ....
  5. Exposure to Bisphenol A & Reproductive Effect in Humans
    De Kun Li; Fiscal Year: 2007
    ..The proposed study will evaluate the reproductive effects of BPA in settings where there have been high levels of exposure. The study will also investigate effects in multiple human generations. ..
  6. MSM Multiscale Modeling of the Heart in Cardiovascular
    DANIEL BEARD; Fiscal Year: 2007
    ..abstract_text> ..
  7. GEORGETOWN UNIVERSITY-MEDSTAR CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE
    Joseph Verbalis; Fiscal Year: 2006
    ..The planning process will be led by a committee of faculty members who are leaders in translational research and clinical research training at the member institutions. [unreadable] [unreadable] [unreadable]..
  8. MECHANISMS OF SULFATE TRANSPORT AND REGULATION
    Michael Jennings; Fiscal Year: 2007
    ..abstract_text> ..
  9. Open Tubular Capillary Electrochromatography/Mass Spectroscopy
    JOSEPH PESEK; Fiscal Year: 2007
    ..This project focuses on providing a means for the analysis of complex samples found in clinical, biological and pharmaceutical applications. [unreadable] [unreadable] [unreadable]..
  10. Generation of Collecting Duct Knockout of PPARgamma
    Tianxin Yang; Fiscal Year: 2006
    ..New information provided by this proposal is expected to provide insights into the roles of PPARgamma in regulation of fluid balance and in mediation of the side effects of TDZ. ..
  11. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2010
    ..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
  12. Improved Measurements of Vocal Fold-Related Tissues
    Sarah Klemuk; Fiscal Year: 2006
    ..Surface roughness of plate and substrate surfaces will be quantified using SEM technology and Scanning Probe Microscopy. [unreadable] [unreadable]..
  13. Harbor-UCLA Initiative for Minority Student Development
    Christina Wang; Fiscal Year: 2005
    ....
  14. Molecular Physioloy of Brain Cation-Cl Cotransporters
    Eric Delpire; Fiscal Year: 2006
    ..abstract_text> ..
  15. MUSCARINIC RECEPTOR COUPLING TO INOSITIDES IN CNS
    Stephen Fisher; Fiscal Year: 2006
    ..Accordingly, knowledge of the signal transduction pathways that regulate VSOAC is an essential prerequisite for the rational design of therapeutic agents. ..
  16. Analysis of Large-Scale Biochemical Systems
    DANIEL BEARD; Fiscal Year: 2007
    ..In addition, the computational tools that are developed by this research program will be disseminated through a partnership with a software company. [unreadable] [unreadable] [unreadable]..
  17. Physiologic role of collecting duct ciiliary proteins
    Donald Kohan; Fiscal Year: 2007
    ..Most importantly, this work may shed light on novel mechanisms involved in control of blood pressure and development of hypertension. [unreadable] [unreadable] [unreadable]..
  18. Pressure-enhanced near-infrared breast cancer imaging
    Shudong Jiang; Fiscal Year: 2008
    ....
  19. HYPONATREMIA-INDUCED OSTEOPOROSIS
    Joseph G Verbalis; Fiscal Year: 2010
    ....
  20. MECHANISMS OF WATER FLOW ACROSS BIOLOGICAL MEMBRANES
    Mark Zeidel; Fiscal Year: 2009
    ..Building on substantial prior progress, this competing renewal seeks to define at a molecular level the mechanisms by which water and other small molecules cross barrier membranes, AQP's, and UT's. ..
  21. EGFR Targeted Nanoparticles to Overcome Paclitaxel Resistant Breast Cancer
    RUSSELL MUMPER; Fiscal Year: 2009
    ..The innovation of this proposal relates to nanotemplate engineering of biocompatible nanoparticles, overcoming multi- drug resistance, and the use of nanotechnology to engineer a cell-targeted cancer therapy. ..
  22. MATHEMATICAL MODELS OF RENAL DYNAMICS
    HAROLD LAYTON; Fiscal Year: 2009
    ..abstract_text> ..
  23. Prenatal MF Exposure & Miscarriage Risk Among Women
    De Kun Li; Fiscal Year: 2009
    ..The findings from the proposed study will provide much needed confirmation of the recently reported results and advance our understanding of a MF health effect. ..
  24. Cerebral edema in pediatric ketoacidosis
    Nicole Glaser; Fiscal Year: 2009
    ..This initial animal data will form the basis for a randomized clinical trial of interventions for the prevention of CE in children with DKA which will be the main focus of the study. ..
  25. Collecting duct endothelin-1 and hypertension
    Donald Kohan; Fiscal Year: 2009
    ..Such information is important in understanding intrarenal mechanisms responsible for hypertension and salt and water retention. ..
  26. Nanoparticle HIV Protein Vaccines for Cellular Responses
    RUSSELL MUMPER; Fiscal Year: 2009
    ..In addition, Dr. Nath's lab will produce vaccinia expressing antigen. ..
  27. Cellular Mechanisms Controlling Dog Oocyte Maturation
    Nucharin Songsasen; Fiscal Year: 2008
    ....
  28. Are IQs low in offspring of euthyroid women with low T4
    Wendy Craig; Fiscal Year: 2008
    ..It is intended that the study be continued for five more years (total of 10) in order to obtain additional estimates of neuropsychological development in the children at a time when more extensive testing can be performed. ..
  29. Renal medullary COX-2 in blood pressure control
    Tianxin Yang; Fiscal Year: 2008
    ..The information resulted from these studies will provide new insight into the molecular mechanism responsible for long-term control of arterial blood pressure. ..
  30. Interaction of COX-2 AND nNOS in renin secretion (R01)
    Tianxin Yang; Fiscal Year: 2008
    ..abstract_text> ..
  31. Modulators of CL-dependent Transport Processes (RMI)
    Eric Delpire; Fiscal Year: 2005
    ....
  32. The Contact Lens and Dry Eye Study
    Jason Nichols; Fiscal Year: 2006
    ..The long-term objective of this research is to contribute to a better understanding of the etiology and risk factors for contact lens-related dry eye so that progress can be made toward its prevention. ..
  33. REDUCTASE INTERACTIONS GOVERNING AROMATASE ACTIVITIES
    Alan Conley; Fiscal Year: 2001
    ..abstract_text> ..
  34. EFFECT OF SHIGATOXIN-1 ON BRAIN ENDOTHELIAL CELLS
    Donald Kohan; Fiscal Year: 2004
    ....
  35. The Molecular Basis of Ovarian Testosterone Production
    Robert Rosenfield; Fiscal Year: 2004
    ..The overall goal of this proposal is to understand the factors regulating the production of testosterone in women, particularly in their ovaries. ..
  36. Assesment of a Chronic Subcutaneous Glucose Sensor
    W Ward; Fiscal Year: 2003
    ..ether-based polymer. We will compare their long term function in studies using rabbits, which will be also be used to ascertain the effect of the growth factors and the real-time data processing. ..
  37. NANOTEMPLATE ENGINEERING OF CELL-SPECIFIC NANOPARTICLES
    RUSSELL MUMPER; Fiscal Year: 2003
    ..Ideally, data from these therapeutic studies may help to advance these innovative nanotechnologies toward clinical investigation. ..
  38. PHYSIOLOGICAL ADAPTATION TO SUSTAINED HYPO-OSMOLALITY
    Joseph Verbalis; Fiscal Year: 2002
    ..These studies should lead to an elucidation of the cellular mechanisms underlying one of the most basic and intriguing unanswered question about clinically hyponatremic disorders. ..
  39. Development of Etched Modified Capillaries
    JOSEPH PESEK; Fiscal Year: 2002
    ..Microsolv Corporation will undertake a marketing plan to distribute the products for use by companies working in the targeted application areas. ..
  40. Estrogen and the Aging Blood Brain Barrier
    OAK CHI; Fiscal Year: 2002
    ..The information obtained from our study will be crucially important for the clinical application of estrogen therapy for stroke as well as understanding the pathophysiology of age related cerebrovascular changes. ..
  41. INDICES OF BIOTIN NUTRITION
    Donald Mock; Fiscal Year: 2001
    ..4) Whether biotin deficiency of similar severity to that observed either early or late in human gestation causes increased rates of fetal malformation in the mouse. 5) The enzyme(s) responsible for biotin beta-oxidation. ..
  42. 3 D HOLOGRAPHIC VIDEO RECORDING IN BIOLOGICAL TISSUE
    David Nolte; Fiscal Year: 2001
    ....
  43. FREE PLASMA SEX HORMONE AND ANDROGEN ACTION
    Robert Rosenfield; Fiscal Year: 2001
    ....
  44. INDUCED ABORTION AND BREAST CANCER RISK
    De Kun Li; Fiscal Year: 2001
    ....
  45. SHIGA LIKE TOXIN AND RENAL CELL DYSFUNCTION
    Donald Kohan; Fiscal Year: 2001
    ..These studies provide essential information on how and why HGEN are damaged in HUS. ..
  46. Optical Imaging of Seizure Activity in Adult Neocortex
    DARYL HOCHMAN; Fiscal Year: 2004
    ....
  47. Mechanisms of renal cell adaptation to hypertonicity
    DIETMAR KUELTZ; Fiscal Year: 2006
    ..Aim 4: By studying the proteins that are targeted by GADD45 proteins during hypertonic stress in renal inner medullary cells. ..
  48. MoAbs for the Management of Pancreatic Cancer
    David Gold; Fiscal Year: 2005
    ..Finally, a PAM4IL2 fusion protein will be examined for its ability to enhance tumor uptake of a subsequently administered radiolabeled PAM4 antibody. ..
  49. BRAIN OXYTOCIN AND ETHANOL EFFECT ON INGESTIVE BEHAVIOR
    Joseph Verbalis; Fiscal Year: 2001
    ....
  50. PRESERVATION OF GENETIC LINES IN A NON MAMMALIAN SYSTEM
    Mary Hagedorn; Fiscal Year: 2005
    ..Most importantly, these somatic changes will not affect the germ line, so they are ideal for genomic banking to maintain important genetic stocks for biomedical and endangered fish research. ..
  51. Gene Polymorphisms, Preterm Birth, Neonatal Complicatio*
    Steven Witkin; Fiscal Year: 2005
    ..Identification of genetic factors in mothers or their neonates that influence susceptibility to preterm labor and fetal morbidity in different racial groups will aid in development of improved protocols for monitoring and treatment...
  52. New Paradigms of P450-mediated Steroids Metabolism
    Alan Conley; Fiscal Year: 2006
    ..abstract_text> ..
  53. Passivating Proteins in Implantable Glucose Sensors
    W Ward; Fiscal Year: 2004
    ..8. A histologic evaluation will be performed to assess the effect of passivating proteins and antibody blocked fibrinogen on the nature of the foreign body capsule. ..
  54. Prostate Cancer Development & Growth
    Christina Wang; Fiscal Year: 2004
    ..The results will provide the important missing link between diet fat and CaP growth and development. ..
  55. Ninth International Conference on Endothelin (ET-9)
    Donald Kohan; Fiscal Year: 2005
    ..abstract_text> ..
  56. EFFECT OF DIABETES AND HYPERTENSION ON ISCHEMIC INJURY
    Stephen Schaffer; Fiscal Year: 2003
    ..Cell culture studies will be complimented by studies using an isolated heart model to test the hypothesis that hypertensive diabetic hearts will be more susceptible to an ischemic insole because of elevated levels of angiotensin. ..
  57. Nanoengineered HIV-1 Vaccines Based on Tat
    RUSSELL MUMPER; Fiscal Year: 2004
    ..The development of an appropriate nanoparticle-based HIV-1 Tat vaccine will also benefit strategies that may incorporate multiple HIV genes such as Tat, Env, Gag, Pol, and Rev. ..
  58. OmpR and acid regulation of Escherichia coli fim genes
    WILLIAM SCHWAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  59. Microbial Fingerprinting Chip and Automated Analysis
    DON DALY; Fiscal Year: 2003
    ..Because the method and DNA chip is "universal", it may be applicable for the identification of other microorganism, as demonstrated in our preliminary studies with Salmonella, Xanthomonas and E. coli pathogens. ..
  60. Prenatal NSAID Use and Miscarriage
    De Kun Li; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  61. Genetics of Angiotensinogen-Mediated Hypertension: Stage, Background & Gender
    Donald E Kohan; Fiscal Year: 2010
    ..Our goal is to advance the specificity of clinical management and treatment of EH. ..
  62. Correlation of MRI with Cartilage Mechanical Stiffness
    Martha Gray; Fiscal Year: 2006
    ..abstract_text> ..
  63. Reducing Renal TGF-B in Diabetic Glomerulosclerosis
    MARGO COHEN; Fiscal Year: 2005
    ..abstract_text> ..
  64. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2003
    ....
  65. 2007 Cellular Osmoregulation: Sensors, Tranducers & Regulators Gordon Research Co
    PAUL YANCEY; Fiscal Year: 2007
    ..In all aspects of the conference, the organizers are working to promote the involvement of women, minorities and people with disabilities. [unreadable] [unreadable] [unreadable]..
  66. Role of COX2 in Medullary Interstitial Cell Survival and Function
    Gilbert Moeckel; Fiscal Year: 2008
    ..It is necessary to understand how these cells function in order to design better drugs to treat high blood pressure. [unreadable] [unreadable]..
  67. CONTROL OF SODIUM INTAKE IN THE HINDLIMB UNWEIGHTED RAT
    J Cunningham; Fiscal Year: 2005
    ..Additionally, these data may contribute to understanding of health problems associated with an aging population and with cardiovascular disease such as congestive heart failure. ..
  68. NEURAL REGULATION OF VASOPRESSIN RELEASE
    J Thomas Cunningham; Fiscal Year: 2010
    ..Benefits: The results will provide new information regarding the control of vasopressin secretion and how these systems contribute to pathophysiology. ..
  69. In-Home Prevention of SA risks in Native Teen Families
    John T Walkup; Fiscal Year: 2010
    ....
  70. Risk for Depression Stress and Neuroendocrine Function
    AUDREY TYRKA; Fiscal Year: 2008
    ..This R01 proposal will entail a prospective longitudinal investigation of the effects of childhood adversity and maternal mood and anxiety disorders on the development of neuroendocrine dysfunction and psychopathology. ..
  71. Delivery Systems for Precision Brain Cell Targeting
    Scott Banta; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  72. Workshop on Methods for Macromolecular Modeling
    Tamar Schlick; Fiscal Year: 2004
    ....
  73. Mechanisms of DNA Polymerases
    Tamar Schlick; Fiscal Year: 2007
    ..Such studies have immediate applications to the diagnostics, and eventually treatment via polymerase inhibitors, of human diseases caused by defective repair of DNA, like various cancers and premature aging. ..