Genomes and Genes
tertiary protein structure
Summary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Publications291 found, 100 shown here
- Integrins: bidirectional, allosteric signaling machinesRichard O Hynes
Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 110:673-87. 2002..Long-range conformational changes couple these functions via allosteric equilibria...
- Translating the histone codeT Jenuwein
Research Institute of Molecular Pathology IMP at the Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
Science 293:1074-80. 2001....
- The protein kinase complement of the human genomeG Manning
SUGEN Inc, 230 East Grand Avenue, South San Francisco, CA 94080, USA
Science 298:1912-34. 2002..We also identified 106 protein kinase pseudogenes. Chromosomal mapping revealed several small clusters of kinase genes and revealed that 244 kinases map to disease loci or cancer amplicons...
- Assignment of homology to genome sequences using a library of hidden Markov models that represent all proteins of known structureJ Gough
Laboratory of Molecular Biology, MRC, Hills Road, Cambridge, CB2 2QH, UK
J Mol Biol 313:903-19. 2001..The annotations derived from these matches are available from a public web server at: http://stash.mrc-lmb.cam.ac.uk/SUPERFAMILY. This server also enables users to match their own sequences against the SUPERFAMILY model library...
- PRODRG: a tool for high-throughput crystallography of protein-ligand complexesAlexander W Schuttelkopf
Division of Biological Chemistry and Molecular Microbiology, Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Dow Street, DD1 5EH, Scotland
Acta Crystallogr D Biol Crystallogr 60:1355-63. 2004..However, tests with distorted starting coordinates show that PRODRG topologies perform better, both in terms of ligand geometry and of crystallographic R factors...
- Systematic functional analysis of the Caenorhabditis elegans genome using RNAiRavi S Kamath
Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Nature 421:231-7. 2003..Our resulting data set and reusable RNAi library of 16,757 bacterial clones will facilitate systematic analyses of the connections among gene sequence, chromosomal location and gene function in C. elegans...
- ESPript/ENDscript: Extracting and rendering sequence and 3D information from atomic structures of proteinsPatrice Gouet
Laboratoire de BioCristallographie, IBCP CNRS UMR 5086 UCBL, 7 passage du Vercors, 69367 Lyon Cedex 07, France
Nucleic Acids Res 31:3320-3. 2003..ESPript and ENDscript are available at http://genopole.toulouse.inra.fr/ESPript...
- The genome of black cottonwood, Populus trichocarpa (Torr. & Gray)G A Tuskan
Environmental Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
Science 313:1596-604. 2006..Overrepresented exceptions in Populus include genes associated with lignocellulosic wall biosynthesis, meristem development, disease resistance, and metabolite transport...
- Signals for sorting of transmembrane proteins to endosomes and lysosomesJuan S Bonifacino
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Annu Rev Biochem 72:395-447. 2003..This complex array of signals and recognition proteins ensures the dynamic but accurate distribution of transmembrane proteins to different compartments of the endosomal-lysosomal system...
- The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responsesMitsutoshi Yoneyama
Department of Tumor Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
Nat Immunol 5:730-7. 2004..Subsequent gene activation by these factors induced antiviral functions, including type I interferon production. Thus, RIG-I is key in the detection and subsequent eradication of the replicating viral genomes...
- Scoring function for automated assessment of protein structure template qualityYang Zhang
Center of Excellence in Bioinformatics, University at Buffalo, Buffalo, New York 14203, USA
Proteins 57:702-10. 2004..These data suggest that the TM-score is a useful complement to the fully automated assessment of protein structure predictions. The executable program of TM-score is freely downloadable at http://bioinformatics.buffalo.edu/TM-score...
- Cellular motility driven by assembly and disassembly of actin filamentsThomas D Pollard
Department of Cellular, Molecular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
Cell 112:453-65. 2003..Profilin catalyzes the exchange of ADP for ATP, refilling the pool of ATP-actin monomers bound to profilin, ready for elongation...
- An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptorXuewu Zhang
Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, 94720, USA
Cell 125:1137-49. 2006..The CDK/cyclin-like complex formed by two kinase domains thus explains the activation of EGFR-family receptors by homo- or heterodimerization...
- GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factorsKent L Rossman
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Nat Rev Mol Cell Biol 6:167-80. 2005..The failure to do so can have significant consequences and is reflected in the aberrant function of Dbl-family GEFs in some human diseases...
- Intrinsically unstructured proteins and their functionsH Jane Dyson
Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Rev Mol Cell Biol 6:197-208. 2005..Many disordered segments fold on binding to their biological targets (coupled folding and binding), whereas others constitute flexible linkers that have a role in the assembly of macromolecular arrays...
- The genome sequence of Schizosaccharomyces pombeV Wood
The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
Nature 415:871-80. 2002....
- Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virusEtienne Meylan
Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Nature 437:1167-72. 2005..Cardif thus functions as an adaptor, linking the cytoplasmic dsRNA receptor RIG-I to the initiation of antiviral programmes...
- MEME: discovering and analyzing DNA and protein sequence motifsTimothy L Bailey
Institute of Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia
Nucleic Acids Res 34:W369-73. 2006..This article describes the freely accessible web server and its architecture, and discusses ways to use MEME effectively to find new sequence patterns in biological sequences and analyze their significance...
- Q-SiteFinder: an energy-based method for the prediction of protein-ligand binding sitesAlasdair T R Laurie
School of Biochemistry and Microbiology, University of Leeds, UK
Bioinformatics 21:1908-16. 2005..Energetically favourable probe sites are clustered according to their spatial proximity and clusters are then ranked according to the sum of interaction energies for sites within each cluster...
- EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapyJ Guillermo Paez
Departments of Medical Oncology and Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Science 304:1497-500. 2004..These results suggest that EGFR mutations may predict sensitivity to gefitinib...
- Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complexNing Zheng
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York 10021, USA
Nature 416:703-9. 2002..The structure suggests that Cul1 may contribute to catalysis through the positioning of the substrate and the ubiquitin-conjugating enzyme, and this model is supported by Cul1 mutations designed to eliminate the rigidity of the scaffold...
- Membrane recognition by phospholipid-binding domainsMark A Lemmon
Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 809C Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104 6059, USA
Nat Rev Mol Cell Biol 9:99-111. 2008..A full appreciation of these processes is crucial for understanding how protein localization and membrane topography and trafficking are regulated in cells...
- Role for a bidentate ribonuclease in the initiation step of RNA interferenceE Bernstein
Cold Spring Harbor Laboratory, New York 11724, USA
Nature 409:363-6. 2001..The enzyme has a distinctive structure, which includes a helicase domain and dual RNase III motifs. Dicer also contains a region of homology to the RDE1/QDE2/ARGONAUTE family that has been genetically linked to RNAi...
- Modeller: generation and refinement of homology-based protein structure modelsAndras Fiser
Department of Biochemistry and Seaver Foundation Center for Bioinformatics, Albert Einstein College of Medicine, Bronz, New York 10461, USA
Methods Enzymol 374:461-91. 2003
- AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus buddingBettina Strack
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Cell 114:689-99. 2003..These observations identify AIP1 as a component of the viral budding machinery, which serves to link a distinct region in the L domain of HIV-1 p6 and EIAV p9 to ESCRT-III...
- SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteinsDavid C Schultz
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Genes Dev 16:919-32. 2002..Thus, KAP-1 is a molecular scaffold that is targeted by KRAB-ZFPs to specific loci and coordinates both histone methylation and the deposition of HP1 proteins to silence gene expression...
- Data growth and its impact on the SCOP database: new developmentsAntonina Andreeva
MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 0QH, UK
Nucleic Acids Res 36:D419-25. 2008..SCOP can be accessed at http://scop.mrc-lmb.cam.ac.uk/scop...
- Shelterin: the protein complex that shapes and safeguards human telomeresTitia de Lange
The Rockefeller University, New York, New York 10021, USA
Genes Dev 19:2100-10. 2005..Six shelterin subunits: TRF1, TRF2, TIN2, Rap1, TPP1, and POT1...
- Carbohydrate-binding modules: fine-tuning polysaccharide recognitionAlisdair B Boraston
Biochemistry and Microbiology, University of Victoria, PO Box 3055 STN CSC, Victoria, BC, Canada V8W 3P6
Biochem J 382:769-81. 2004..The present review summarizes the impact structural biology has had on our understanding of the mechanisms by which CBMs bind to their target ligands...
- Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemiaAndrew P Weng
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Science 306:269-71. 2004..These findings greatly expand the role of activated NOTCH1 in the molecular pathogenesis of human T-ALL and provide a strong rationale for targeted therapies that interfere with NOTCH signaling...
- FOXP3 controls regulatory T cell function through cooperation with NFATYongqing Wu
Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309, USA
Cell 126:375-87. 2006..Thus by switching transcriptional partners, NFAT converts the acute T cell activation program into the suppressor program of Tregs...
- BAR domains as sensors of membrane curvature: the amphiphysin BAR structureBrian J Peter
Medical Research Council MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Science 303:495-9. 2004..From this, we predict that BAR domains are in many protein families, including sorting nexins, centaurins, and oligophrenins. The universal and minimal BAR domain is a dimerization, membrane-binding, and curvature-sensing module...
- Structure of the guide-strand-containing argonaute silencing complexYanli Wang
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Nature 456:209-13. 2008....
- InterProScan: protein domains identifierE Quevillon
European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
Nucleic Acids Res 33:W116-20. 2005..O'Reilly Publishers, Sebastopol, CA, http://www.w3.org/TR/soap/] are also available to the users. Various output formats are supported and include text tables, XML documents, as well as various graphs to help interpret the results...
- Structure of the dengue virus envelope protein after membrane fusionYorgo Modis
Howard Hughes Medical Institute, Children s Hospital and Harvard Medical School, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
Nature 427:313-9. 2004..Specific features of the folded-back structure suggest strategies for inhibiting flavivirus entry...
- Mutations of the BRAF gene in human cancerHelen Davies
Cancer Genome Project, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK
Nature 417:949-54. 2002..As BRAF is a serine/threonine kinase that is commonly activated by somatic point mutation in human cancer, it may provide new therapeutic opportunities in malignant melanoma...
- Function and regulation of cullin-RING ubiquitin ligasesMatthew D Petroski
Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
Nat Rev Mol Cell Biol 6:9-20. 2005..In this review, we focus on the composition, regulation and function of cullin-RING ligases, and describe how these enzymes can be characterized by a set of general principles...
- Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptideMi Sun Jin
Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejon, Korea 305 701
Cell 130:1071-82. 2007..We propose that formation of the TLR1-TLR2 heterodimer brings the intracellular TIR domains close to each other to promote dimerization and initiate signaling...
- DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2S Y Shieh
Department of Biological Sciences, Columbia University, New York, New York 10027, USA
Cell 91:325-34. 1997..Our studies provide a plausible mechanism by which the induction of p53 can be modulated by DNA-PK (or other protein kinases with similar specificity) in response to DNA damage...
- Molecular dynamics and protein functionM Karplus
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 102:6679-85. 2005..We also describe results for the F(1) ATPase molecular motor and the Src family of signaling proteins as examples of applications of simulations to specific biological systems...
- IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon inductionTaro Kawai
Exploratory Research for Advanced Technology, Japan Science and Technology Agency
Nat Immunol 6:981-8. 2005..Knockdown' of IPS-1 by small interfering RNA blocked interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses...
- GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor functionDaniel M Rosenbaum
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
Science 318:1266-73. 2007..Amino acids known to regulate receptor function are linked through packing interactions and a network of hydrogen bonds, suggesting a conformational pathway from the ligand-binding pocket to regions that interact with G proteins...
- SMART 6: recent updates and new developmentsIvica Letunic
EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany
Nucleic Acids Res 37:D229-32. 2009..In addition to the standard web access to the database, users can now query SMART using distributed annotation system (DAS) or through a simple object access protocol (SOAP) based web service...
- Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaksYentram Huyen
Wistar Institute, Philadelphia, Pennsylvania 19104 4268, USA
Nature 432:406-11. 2004..Because methylation of histone H3 Lys 79 was unaltered in response to DNA damage, we propose that 53BP1 senses DSBs indirectly through changes in higher-order chromatin structure that expose the 53BP1 binding site...
- Structural basis for RNA unwinding by the DEAD-box protein Drosophila VasaToru Sengoku
Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Tokyo 113 0033, Japan
Cell 125:287-300. 2006..This mechanism, which differs from those for canonical translocating helicases, may enable the targeted modulation of intricate RNA structures...
- Structural basis of integrin regulation and signalingBing Hao Luo
The CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Annu Rev Immunol 25:619-47. 2007..In this review, we focus on integrin structure as it relates to affinity modulation, ligand binding, outside-in signaling, and cell surface distribution dynamics...
- The Pfam protein families databaseAlex Bateman
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Nucleic Acids Res 32:D138-41. 2004..Pfam is available on the web in the UK (http://www.sanger.ac.uk/Software/Pfam/), the USA (http://pfam.wustl.edu/), France (http://pfam.jouy.inra.fr/) and Sweden (http://Pfam.cgb.ki.se/)...
- The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domainsB K Kay
Department of Pharmacology, University of Wisconsin Madison, Madison, Wisconsin 53706 1532, USA
FASEB J 14:231-41. 2000..Kay, B. K., Williamson, M. P., Sudol, M. The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains...
- The transcriptional coactivators p300 and CBP are histone acetyltransferasesV V Ogryzko
Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2753, USA
Cell 87:953-9. 1996..p300/CBP acetylates all four core histones in nucleosomes. These observations suggest that p300/CBP acetylates nucleosomes in concert with PCAF...
- Structural classification of zinc fingers: survey and summaryS Sri Krishna
Department of Biochemistry, University of Texas, Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
Nucleic Acids Res 31:532-50. 2003..The classification helps in understanding the relationship between the structure, function and evolutionary history of these domains. The results are available as an online database of zinc finger structures...
- A structural perspective of the flavivirus life cycleSuchetana Mukhopadhyay
Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, Indiana 47907 2054, USA
Nat Rev Microbiol 3:13-22. 2005..This review focuses mainly on structural studies of dengue virus...
- R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathwayQinghua Liu
Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Science 301:1921-5. 2003..These results indicate that R2D2 bridges the initiation and effector steps of the Drosophila RNAi pathway by facilitating siRNA passage from Dicer to RISC...
- Protein structure prediction and analysis using the Robetta serverDavid E Kim
Structural Genomics of Pathogenic Protozoa, Department of Biochemistry, University of Washington, Seattle WA 98195, USA
Nucleic Acids Res 32:W526-31. 2004..The Rosetta protein design and protein-protein docking methodologies will soon be available through the server as well...
- Fuzzy complexes: polymorphism and structural disorder in protein-protein interactionsPeter Tompa
Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
Trends Biochem Sci 33:2-8. 2008..Given the crucial role of protein disorder in protein-protein interactions and in regulatory processes, we envision that fuzziness will become integral to understanding the interactome...
- FAK integrates growth-factor and integrin signals to promote cell migrationD J Sieg
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
Nat Cell Biol 2:249-56. 2000..Our results establish that FAK is an important receptor-proximal link between growth-factor-receptor and integrin signalling pathways...
- Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolutionDmitry G Vassylyev
Cellular Signaling Laboratory, RIKEN Harima Institute at SPring 8, 1 1 1 Kouto, Mikazuki cho, Sayo, Hyogo 679 5148, Japan
Nature 417:712-9. 2002..The holoenzyme structure provides insight into the structural organization of transcription intermediate complexes and into the mechanism of transcription initiation...
- Diversity and complexity in DNA recognition by transcription factorsGwenael Badis
Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada
Science 324:1720-3. 2009..This complexity in DNA recognition may be important in gene regulation and in the evolution of transcriptional regulatory networks...
- Double chromodomains cooperate to recognize the methylated histone H3 tailJohn F Flanagan
Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Nature 438:1181-5. 2005..Furthermore, unique inserts within chromodomain 1 of CHD1 block the expected site of H3 tail binding seen in HP1 and Polycomb, instead directing H3 binding to a groove at the inter-chromodomain junction...
- The DEAD-box protein family of RNA helicasesOlivier Cordin
Département de Microbiologie et Médecine Moléculaire, Centre Medical Universitaire, 1 rue Michel Servet, 1211, Geneve 4, Switzerland
Gene 367:17-37. 2006..This review will focus on the description of the molecular characteristics of members of the DEAD-box protein family and on the enzymatic activities they possess...
- Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifsJohn C Obenauer
Center for Cancer Research, E18 580, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Nucleic Acids Res 31:3635-41. 2003..In addition, a new series of Sequence Match programs for non-quantitative user-defined motifs has been implemented. Scansite is available via the World Wide Web at http://scansite.mit.edu...
- The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNAJafar Sharif
Tohoku University Biomedical Engineering Research Organization TUBERO, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
Nature 450:908-12. 2007..The link between hemi-methylated DNA, Np95 and Dnmt1 thus establishes key steps of the mechanism for epigenetic inheritance of DNA methylation...
- Edc3p and a glutamine/asparagine-rich domain of Lsm4p function in processing body assembly in Saccharomyces cerevisiaeCarolyn J Decker
Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721
J Cell Biol 179:437-49. 2007..These results suggest a stepwise model for P-body assembly with the initial formation of a core mRNA-protein complex that then aggregates through multiple specific mechanisms...
- DNA-binding specificity of the ERF/AP2 domain of Arabidopsis DREBs, transcription factors involved in dehydration- and cold-inducible gene expressionYoh Sakuma
Biological Resources Division, Japan International Research Center for Agricultural Sciences JIRCAS, 1 1 Ohwashi, Tsukuba, Ibaraki, 305 8686, Japan
Biochem Biophys Res Commun 290:998-1009. 2002..The DREB subfamily included three novel DREB1A- and six DREB2A-related proteins. We analyzed expression of novel genes for these proteins and discuss their roles in stress-responsive gene expression...
- The CATH classification revisited--architectures reviewed and new ways to characterize structural divergence in superfamiliesAlison L Cuff
Institute of Structural and Molecular Biology, University College London, London, WC1E 6BT, UK
Nucleic Acids Res 37:D310-4. 2009..Information on the degree of structural diversity in each superfamily and structural overlaps between superfamilies can now be downloaded from the CATH website...
- JmjC-domain-containing proteins and histone demethylationRobert J Klose
Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
Nat Rev Genet 7:715-27. 2006..Here we analyse the evolutionary relationship between Jumonji C (JmjC)-domain-containing proteins and discuss their cellular functions in relation to their potential enzymatic activities...
- Fibronectin at a glanceRoumen Pankov
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Sci 115:3861-3. 2002
- Purified Argonaute2 and an siRNA form recombinant human RISCFabiola V Rivas
Cold Spring Harbor Laboratory, Watson School of Biological Sciences, New York 11724, USA
Nat Struct Mol Biol 12:340-9. 2005..These studies demonstrate that Argonaute proteins catalyze mRNA cleavage within RISC and provide a source of recombinant enzyme for detailed biochemical studies of the RNAi effector complex...
- Refined structure of the nicotinic acetylcholine receptor at 4A resolutionNigel Unwin
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
J Mol Biol 346:967-89. 2005..Access to the pore on the intracellular side is further influenced by narrow lateral windows, which would be expected to screen out electrostatically ions of the wrong charge and size...
- Prions affect the appearance of other prions: the story of [PIN(+)]I L Derkatch
Laboratory for Molecular Biology, Department of Biological Sciences, University of Illinois at Chicago, 900 South Ashland Avenue, Chicago, IL 60607, USA
Cell 106:171-82. 2001..Importantly, the de novo appearance of Rnq1::GFP prion aggregates also requires the presence of other prions, suggesting the existence of a general mechanism by which the appearance of prions is enhanced by heterologous prion aggregates...
- Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivityCai Hong Yun
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, MA 02115, USA
Cancer Cell 11:217-27. 2007..Strikingly, direct binding measurements show that gefitinib binds 20-fold more tightly to the L858R mutant than to the wild-type enzyme...
- Crystal structure of a mammalian voltage-dependent Shaker family K+ channelStephen B Long
Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Science 309:897-903. 2005..Electrostatic properties of the side portals and positions of the T1 domain and beta subunit are consistent with electrophysiological studies of inactivation gating and with the possibility of K+ channel regulation by the beta subunit...
- Themes and variations on ubiquitylationA M Weissman
Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 1152, USA
Nat Rev Mol Cell Biol 2:169-78. 2001..A few years ago, we could only have dreamt of the complex arsenal of enzymes dedicated to ubiquitylation. Why has nature come up with so many ways of doing what seems to be such a simple job?..
- DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNASteen K T Ooi
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Nature 448:714-7. 2007..These data indicate that DNMT3L recognizes histone H3 tails that are unmethylated at lysine 4 and induces de novo DNA methylation by recruitment or activation of DNMT3A2...
- Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradationP Kavsak
Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada
Mol Cell 6:1365-75. 2000..These studies thus define Smad7 as an adaptor in an E3 ubiquitin-ligase complex that targets the TGF beta receptor for degradation...
- Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist EritoranHo Min Kim
Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejon, Korea 305 701
Cell 130:906-17. 2007..The interaction with Eritoran is mediated by a hydrophobic internal pocket in MD-2. Based on structural analysis and mutagenesis experiments on MD-2 and TLR4, we propose a model of TLR4-MD-2 dimerization induced by LPS...
- Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotesJ L Riechmann
Mendel Biotechnology, 21375 Cabot Boulevard, Hayward, CA 94545, USA
Science 290:2105-10. 2000..The genome-wide comparison reveals the evolutionary generation of diversity in the regulation of transcription...
- Evolution of protein kinase signaling from yeast to manGerard Manning
Sugen Inc 230 East Grand Ave, South San Francisco, CA 94080, USA
Trends Biochem Sci 27:514-20. 2002....
- Structure of a bacterial multidrug ABC transporterRoger J P Dawson
Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
Nature 443:180-5. 2006....
- The guanine nucleotide-binding switch in three dimensionsI R Vetter
, 44227 Dortmund, Germany
Science 294:1299-304. 2001..Here we will try to define some underlying principles...
- Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesisMarzena Bienko
Institute for Biochemistry II, Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt, Germany
Science 310:1821-4. 2005..Our results indicate that Ub-binding domains of Y-family polymerases play crucial regulatory roles in TLS...
- PDBsum new thingsRoman A Laskowski
European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
Nucleic Acids Res 37:D355-9. 2009..Furthermore, it now accepts users' own PDB format files and generates a private set of analyses for each uploaded structure...
- Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplificationM E Gorre
Department of Medicine, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
Science 293:876-80. 2001..These studies provide evidence that genetically complex cancers retain dependence on an initial oncogenic event and suggest a strategy for identifying inhibitors of STI-571 resistance...
- Macromolecular TLS refinement in REFMAC at moderate resolutionsMartyn D Winn
Daresbury Laboratory, Daresbury, Warrington, WA4 4AD, United Kingdom
Methods Enzymol 374:300-21. 2003
- Toward high-resolution de novo structure prediction for small proteinsPhilip Bradley
University of Washington, Department of Biochemistry, and Howard Hughes Medical Institute, Box 357350, Seattle, WA 98195, USA
Science 309:1868-71. 2005..5 angstroms) can be achieved for small protein domains (<85 residues). The primary bottleneck to consistent high-resolution prediction appears to be conformational sampling...
- The molecular architecture of axonemes revealed by cryoelectron tomographyDaniela Nicastro
Laboratory for 3D Electron Microscopy of Cells, Department of Molecular, Cellular, and Developmental Biology, CB 347, University of Colorado, Boulder, CO 80309 0347, USA
Science 313:944-8. 2006..Periodic densities were also observed inside doublet microtubules; these may contribute to doublet stability...
- Insights into DNA recombination from the structure of a RAD51-BRCA2 complexLuca Pellegrini
University of Cambridge, Department of Biochemistry, Tennis Court Road, Cambridge CB2 1GA, UK
Nature 420:287-93. 2002..Cancer-associated mutations that affect the BRC repeat disrupt its predicted interaction with RAD51, yielding structural insight into mechanisms for cancer susceptibility...
- Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assemblyJ Nakayama
Cold Spring Harbor Laboratory, Post Office Box 100, Cold Spring Harbor, NY 11724, USA
Science 292:110-3. 2001..These data define a conserved pathway wherein sequential histone modifications establish a "histone code" essential for the epigenetic inheritance of heterochromatin assembly...
- Transcriptional control by the TGF-beta/Smad signaling systemJ Massague
Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
EMBO J 19:1745-54. 2000
- SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-boxC Bai
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
Cell 86:263-74. 1996..Different skp1 mutants arrest cells in either G1 or G2, suggesting a connection between regulation of proteolysis in different stages of the cycle...
- Crystal structure of the extracellular segment of integrin alpha Vbeta3J P Xiong
Renal Unit, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
Science 294:339-45. 2001..MIDAS lies adjacent to a calcium-binding site with a potential regulatory function...
- Dynamic interaction of BiP and ER stress transducers in the unfolded-protein responseA Bertolotti
Skirball Institute of Biomolecular Medicine, Departments of Medicine and Cell Biology and the Kaplan Cancer Center, New York University School of Medicine, New York, New York 10016, USA
Nat Cell Biol 2:326-32. 2000..These findings are consistent with a model in which BiP represses signalling through PERK and IRE1 and protein misfolding relieves this repression by effecting the release of BiP from the PERK and IRE1 lumenal domains...
- Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligandJian Ping Xiong
Renal Unit, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
Science 296:151-5. 2002..Ligand binding induces small changes in the orientation of alphaV relative to beta3...
- Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteinsToshiki Itoh
Department of Cell Biology and Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Dev Cell 9:791-804. 2005..These results suggest a close interplay between the mechanisms that control actin dynamics and those that mediate plasma membrane invagination and fission...
- Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunityMitsutoshi Yoneyama
Antiviral Innate Immunity Project, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, Honkomagome, Tokyo, Japan
J Immunol 175:2851-8. 2005..These results highlight ingenious mechanisms for initiating antiviral innate immune responses and the action of virus-encoded inhibitors...
- The structural basis for cap binding by influenza virus polymerase subunit PB2Delphine Guilligay
Grenoble Outstation, European Molecular Biology Laboratory, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France
Nat Struct Mol Biol 15:500-6. 2008..These findings clarify the nature of the cap binding site in PB2 and will allow efficient structure-based design of new anti-influenza compounds inhibiting viral transcription...
- Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coliMichael J Kerner
Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
Cell 122:209-20. 2005..We suggest that the chaperonin system may have facilitated the evolution of this fold into a versatile platform for the implementation of numerous enzymatic functions...
- CD-Search: protein domain annotations on the flyAron Marchler-Bauer
Computational Biology Branch, NCBI, National Library of Medicine, NIH, Building 38A, Room 5S508, 8600 Rockville Pike, Bethesda, MD 20894, USA
Nucleic Acids Res 32:W327-31. 2004..CD-Search can be accessed at http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi...
- Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domainA J Bannister
Wellcome CRC Institute and Department of Pathology, University of Cambridge, UK
Nature 410:120-4. 2001..This model may also explain the stable inheritance of the heterochromatic state...
- Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCMAlberto Ciccia
Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts, UK
Mol Cell 25:331-43. 2007..Our data indicate that the FANCM/FAAP24 complex may play a key role in recruitment of the FA core complex to damaged DNA...
- Coupling of the nucleus and cytoplasm: role of the LINC complexMelissa Crisp
Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610
J Cell Biol 172:41-53. 2006..2005), support a model in which Sun proteins tether nesprins in the ONM via interactions spanning the PNS. In this way, Sun proteins and nesprins form a complex that links the nucleoskeleton and cytoskeleton (the LINC complex)...
- A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60X Cao
The Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111 USA
Science 293:115-20. 2001..This complex potently stimulates transcription via heterologous Gal4- or LexA-DNA binding domains, suggesting that release of the cytoplasmic tail of APP by gamma-cleavage may function in gene expression...
- ApoE4 Structure Correctors as a Therapeutic Approach for Alzheimers DiseaseRobert W Mahley; Fiscal Year: 2013..This amino acid difference gives rise to profound differences in the tertiary protein structure and function...
- Oral administration of TeaMemTM inhibits Alzheimer's disease pathogenesisJun Tan; Fiscal Year: 2009..These studies will lay the foundation for AD clinical trials with pure TeaMemTM or/and piperine (an alkaloid derived from black pepper) in the near future. ..
- Assembly and Function of the Septal Ring in E. coliPIET A DE BOER; Fiscal Year: 2013..A number of SR proteins are, or are actively pursued as, drug targets. This project may lead to the identification of additional promising targets for, and rational designs of, new anti-bacterial drugs. ..
- Synthetic Nanofiber Vaccines for Cocaine AddictionJia Zhou; Fiscal Year: 2013..Also, more broadly, completion of the proposed work will integrate the fields of synthetic chemistry, nanotechnology, immunology, and addiction to significantly impact human health. ..
- Aptamers to distinguish functional modification of target proteins by affinity prSTEVEN SULJAK; Fiscal Year: 2009..Such aptamers could be used for signaling the presence of proteins associated with particular disease states, or potentially as pharmaceutical agents that can block or modify the action of these proteins. ..
- Translocation through TonB-dependent transportersKaren Jakes; Fiscal Year: 2013..Better understanding the mechanisms that mobilize that uptake will allow design of means to inhibit that essential process. ..
- Octyl gallate (OG) and Promotion of non-amyloidogenic processing of APPJun Tan; Fiscal Year: 2013..At the end of these experiments, these studies will provide the molecular basis for the future development of OG as novel and pharmacologically safe agents for Alzheimer's disease prevention/treatment. ..
- CONTENT AND ASSEMBLAGE OF PLATELET GRANULE PROTEINSDaniel Walz; Fiscal Year: 1993..These studies should provide a better understanding of the role of thrombospondin in platelet aggregation, fibrin formation and fibrinolysis and permit the development of synthetic peptides which prevent or attenuate these processes...
- Protein Structure Prediction Using First PrinciplesCHRISTODOULOS ACHILLEUS FLOUDAS; Fiscal Year: 2011..and torsional angle dynamics, and (f) a new proposed approach for the selection of the predicted tertiary protein structure, from the ensemble of low energy protein structures, using a distance dependent force field developed ..
- MMP1 & MMP9: Mechanism of Activation & Substrate BindingGregory Goldberg; Fiscal Year: 2009..Specific Aims 2 and 3 propose to start with the gelatinase model to define biochemical interactions of gelatinases with substrate and to examine how these can enable processive diffusion and enzyme activation. ..
- LOX Pro-peptide Inhibition of FGF Signaling in Oral CancerAMITHA PALAMAKUMBURA; Fiscal Year: 2009..These studies will be of great importance to develop new therapeutic agents for oral cancer. ..
- RXR-Heterodimeric Receptors in the GI TractEllen Li; Fiscal Year: 2006..We propose to study intraheterodimerization interactions between RXR and the minimal peptide by nuclear magnetic resonance techniques. ..
- I-TASSER based atomic-level protein structure predictionYang Zhang; Fiscal Year: 2013..I-TASSER and QUARK methods, the project aims to significantly improving the state of the art of tertiary protein structure prediction, especially for the non- and distant-homology proteins, so that the computational structure ..
- VIRUS RECEPTOR INTERACTION IN ECHOVIRUS INFECTIONJeffrey Bergelson; Fiscal Year: 1999..James Hogle, determine the virus structure by X-ray diffraction. Knowledge of the virus structure, and the isolation of viral cDNA, will facilitate future genetic experiments to identify the viral sites for receptor binding. ..
- Structure-based Directed Evolution of Fast-Maturing GFPsRebekka Wachter; Fiscal Year: 2007..may depend on the strength of a base positioned close to the chromophore-forming amino acids in the tertiary protein structure. Therefore, specific sets of residues in the immediate chromophore environment will be the primary ..
- Determination of ab initio conformational shiftsHAROLD SCHERAGA; Fiscal Year: 2005..the results provided by this proposed research would provide additional assistance for an accurate tertiary protein structure prediction and, consequently, make a significant contribution to the solution of the, as yet unsolved, ..
- STRUCTURAL ORGANIZATION AND PROTEOMICS OF TBThomas Terwilliger; Fiscal Year: 2005..The structural and functional information obtained in this project is to be placed in the public domain by timely deposition in publicly available databases. ..
- Software tools for analysis and visulaization of protein structureEthan A Merritt; Fiscal Year: 2010..The algorithms and computation tools developed as part of this work will be distributed freely, and we will provide web-based state of the art analysis of structures submitted by external researchers. ..
- EXPANDED PROTEIN STRUCTURE REFINEMENT AND VALIDATIONEthan Merritt; Fiscal Year: 2005..This, in turn, will make it easier to identify key biological features such as the presence and conformation of bound ligands, and the nature of hinge and inter-domain motions. ..
- Hydrophobics transport across the outer membraneBert van den Berg; Fiscal Year: 2009..These structures will also allow us to determine whether mechanistic differences exist between LCFA and xenobiotics transport. ..
- ENHANCING COLLECTIN MEDIATED HOST DEFENSEKevan Hartshorn; Fiscal Year: 2001..These experiments should yield important insights into basic collection biology and demonstrate that enhancement of collectin-mediated pulmonary host defense can be achieved in vivo through rational alteration of wild type collectins. ..
- Mechanisms and Function in HAD PhosphotransferasesKaren Allen; Fiscal Year: 2009..abstract_text> ..
- Structural studies on the Initiator protein, IBP39.Maria Schumacher; Fiscal Year: 2008..vaginalis suggests it is a possible target for the treatment of trichomoniasis, which afflicts over 170 million individuals each _,ear, ..
- Proteomic biomarkers for lymphomaGERALD DENIS; Fiscal Year: 2008..The heuristic should be adaptable and extendable to a wide spectrum of human hematologic malignancies, including myeloid leukemias. [unreadable] [unreadable] [unreadable]..
- [Ca2+]i and Secretory Dynamics in Parotid Acinar CellsDavid Yule; Fiscal Year: 2007..abstract_text> ..
- Novel Context-Activated Protide Anti-InfectivesMichael Yeaman; Fiscal Year: 2008..These advances would represent major breakthroughs in the prevention and treatment of these common and increasingly difficult-to-treat infections. [unreadable] [unreadable] [unreadable]..
- Membrane Targeting by PI-binding DomainsTATIANA KUTATELADZE; Fiscal Year: 2009..The results generated by this research may provide new approaches to rational design of anti-tumor therapeutic agents and systems for delivering drugs into cancer cells. ..
- MOLECULAR MECHANISM OF RENAL NA+ DEPENDENT COTRANSPORTAna M Pajor; Fiscal Year: 2010..Understanding how NaDC1 and SdcS work will help us to develop treatments for NaDC1-mediated diseases. ..
- The role of srcasm in keratinocyte biologyJohn Seykora; Fiscal Year: 2009..The in vivo effects of SFKs and Srcasm on epidermal development and function will be determined by characterizing double transgenic strains over-expressing SFKs and Srcasm. ..
- Structural basis of signaling by ING2 PHDTatiana G Kutateladze; Fiscal Year: 2010..These studies will aid in deeper understanding of how the critical ING2-p53 pathways can be therapeutically manipulated and may help to identify new diagnostic markers and targets to prevent and treat cancer. ..
- Regulation of NF-kB by the Akt kinaseLawrence P Kane; Fiscal Year: 2010..Such knowledge may eventually lead to more specific and efficacious treatments for tumors with dysregulated Akt. ..
- The FIAT-ATF4 interaction and the control of bone massRene St Arnaud; Fiscal Year: 2010..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..
- CELL SURFACE STRUCTURE AND TRANSFORMATIONSRichard Hynes; Fiscal Year: 2005..Evaluation of the functions of cell adhesion proteins and the consequences of their misexpression in metastatic cells will lead to new leads for therapeutic interventions against metastasis. ..
- Structural mechanism of DNA segregation by the pSK41 par systemMaria Schumacher; Fiscal Year: 2010..Thus, understanding the structural basis for DNA segregation by this par system will provide several points of potential therapeutic intervention against pSK41 harboring multidrug resistant S. aureus strains. ..
- gp120 covalent analogs as candidate HIV vaccinesSudhir Paul; Fiscal Year: 2008..Novel vaccination strategies and HIV-1 neutralizing Abs will emerge from these studies if the physiological barriers to catalytic Ab synthesis can be bypassed. [unreadable] [unreadable]..
- Proteolytic Antibody HIVcidesSudhir Paul; Fiscal Year: 2007..These studies may identify proteolytic antibodies suitable for further development as a topical HIVcide. [unreadable] [unreadable] [unreadable]..
- Cell Biology of Human Thiamine TransportersVEEDAMALI SUBRAMANIAN; Fiscal Year: 2005....
- DETERMINANTS IN PLATELET MICROBICIDAL PROTEINSMichael Yeaman; Fiscal Year: 2004..Thus, these studies will significantly advance our understanding of antimicrobial host defense, and may yield new modes for its amplification. ..
- X-Ray Optics and Area DetectorLin Chen; Fiscal Year: 2004..Pardi) Structural biology and biochemistry of Telomeres (Cdc13) (Deborah Wuttke) Structural studies of the prokaryotic and eukaryotic chemotaxis pathways (Joseph Falke) Structure and mechanism at the chemical synapse (Michael Stowell) ..
- ANNEXIN PHOSPHORYLATION: CAUSES AND CONSEQUENCESCARL CREUTZ; Fiscal Year: 2004....
- Develop Peptide Inhibitors of the NFAT/AP-1 ComplexLin Chen; Fiscal Year: 2003..These inhibitors may be important tools for studying the basic molecular mechanisms of tolerance induction and may lead to clinical drugs for invoking antigen specific long-term immune tolerance. ..
- GLOMERULAR LAMININS: STRUCTURE AND FUNCTIONChristine Abrass; Fiscal Year: 2003....
- PRESERVATION OF HDL FUNCTION DURING EARLY ATHEROGENESISJOHN BIELICKI; Fiscal Year: 2002..Moreover, the research will uncover novel mechanisms for preserving HDL/LCAT function that can be utilized therapeutically to fight the onset of cardiovascular disease. ..
- STRUCTURE/FUNCTION OF GTC, A NOVEL GOLGI PROTEIN COMPLEXFREDERICK HUGHSON; Fiscal Year: 2002..These studies will provide the first insights into the role of this novel protein complex in the process of intracellular protein traffic. ..
- HUMAN HEPATIC & INTESTINAL UDP GLUCURONOSYLTRANSFERASESAnna Radominska Pandya; Fiscal Year: 2002..abstract_text> ..
- COPPER METALLOBIOCHEMISTRY IN SACCHAROMYCES CEREVISAEDANIEL KOSMAN; Fiscal Year: 2002..Thus, elucidation of the function and modulation of Mac1p in yeast will be broadly relevant to eukaryotic copper and iron metabolism in general. ..
- Matrix and Morphogenesis ConferenceMARION GORDON; Fiscal Year: 2002..This meeting provides a unique opportunity for senior and junior scientists to gather and discuss the latest and most advanced results in the field of extracellular matrix and morphogenesis. ..
- Structural studies of bacterial quorum sensing regulatorMair Churchill; Fiscal Year: 2005..Study the structures and mechanisms to determine similarities to other AHL synthases. ..
- Inhibition of Scar by the HEM2/Abi2/Pir121 ComplexSHAE PADRICK; Fiscal Year: 2005..NMR line broadening experiments will then determine the binding site in terms of specific amino acids and the site will be confirmed by designed point mutants testing the HAP or Arp2/3 binding interfaces. ..
- METABOTROPIC GLUTAMATE RECEPTORS IN BASAL GANGLIACOLLEEN NISWENDER; Fiscal Year: 2009..Furthermore, we will test the hypothesis that agonists or allosteric potentiators of this receptor can provide palliative relief in rodent models of PD by actions in the GP. ..
- Structure:function studies of the glucocorticoid receptorRaj Kumar; Fiscal Year: 2007..unreadable] [unreadable]..
- X-ray diffraction analysis of human adenovirusVijay Reddy; Fiscal Year: 2006..et al. Science 309: 1090-1092, 2005). [unreadable] [unreadable] [unreadable]..
- STRUCTURE/FUNCTION OF SURFACTANT PROTEIN DErika Crouch; Fiscal Year: 2006..As in the past, secreted recombinant proteins with novel structural attributes will be characterized and utilized for collaborative studies of SP-D function. [unreadable] [unreadable]..
- Iron Trafficking to Ribonucleotide ReductasesDANIEL KOSMAN; Fiscal Year: 2006..This work should provide new insight into the assembly of a critical iron prosthetic group in vivo and evidence that this process can be a target for intervention in a viral infection. ..
- Molecular mechanisms of voltage-gated ion channelsHans Peter Larsson; Fiscal Year: 2006..These measurements will be used to determine how S4 moves in the different channels and will further our understanding of the different mechanisms of opening of these two classes of channels. ..
- Gene Therapy of Muscle Wasting From UremiaXiaonan Wang; Fiscal Year: 2005..We believe that the experimental results will shed the insight on the mechanisms of muscle protein degradation, and provide a possible new approach to treat the pathological process of muscle wasting. ..
- THE ROLE OF RB IN THE RETINA & OTHER TISSUESJAMES HARBOUR; Fiscal Year: 2009..Consequently, these aims are highly relevant to the vision statement of the NEI, and they address several major program goals and objectives of the Retinal Diseases Program. ..
- STRUCTURAL STUDIES OF CHROMOSOMAL PROTEIN/DNA COMPLEXESMair Churchill; Fiscal Year: 2002..Structural studies with HMG-D will be valuable for understanding DNA recognition at a level of detail that will be helpful in the design of improved anti-tumor drugs. ..
- Molecular Mechanisms of Mesangial SclerosisChristine Abrass; Fiscal Year: 2009..Understanding transcriptional control of LN isoform expression will add new insights into the role that LN plays in normal glomerulogenesis and that becomes disordered in glomerular disease. ..
- 2005 Bones & Teeth Gordon ConferenceRene St Arnaud; Fiscal Year: 2005..These funds, if granted, will aid immeasurably in allowing the Gordon Research Conference to fulfill its function to stimulate further creativity in bone, cartilage and tooth research. ..
- MOLECULAR ANGLE TRANSITIONS IN MUSCLETHOMAS BURGHARDT; Fiscal Year: 2001....