cyclization

Summary

Summary: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Top Publications

  1. pmc Extreme bendability of DNA less than 100 base pairs long revealed by single-molecule cyclization
    Reza Vafabakhsh
    Department of Physics, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Science 337:1097-101. 2012
  2. ncbi Palladium-catalyzed oxidative carbocyclization/arylation of enallenes
    Tuo Jiang
    Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE 10691, Stockholm, Sweden
    Org Lett 13:5838-41. 2011
  3. ncbi Palladium-catalyzed oxidative diarylating carbocyclization of enynes
    Min Jiang
    Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE 106 91 Stockholm, Sweden
    Org Lett 14:3538-41. 2012
  4. ncbi Effect of peptide fragment size on the propensity of cyclization in collision-induced dissociation: oligoglycine b(2)-b(8)
    Xian Chen
    Department of Chemistry, University of Florida, Gainesville, Florida 32611, USA
    J Am Chem Soc 131:18272-82. 2009
  5. ncbi Cyclization reaction of peptide fragment ions during multistage collisionally activated decomposition: an inducement to lose internal amino-acid residues
    Chenxi Jia
    Chemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People s Republic of China
    J Am Soc Mass Spectrom 18:663-78. 2007
  6. ncbi Bioconjugation with strained alkenes and alkynes
    Marjoke F Debets
    Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ, The Netherlands
    Acc Chem Res 44:805-15. 2011
  7. ncbi A strain-promoted [3 + 2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems
    Nicholas J Agard
    Department of Chemistry, Howard Hughes Medical Institute, University of California, and Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Am Chem Soc 126:15046-7. 2004
  8. ncbi Rapid and quantitative cyclization of multiple peptide loops onto synthetic scaffolds for structural mimicry of protein surfaces
    Peter Timmerman
    Pepscan Systems B V P O Box 2098, 8203 AB Lelystad, The Netherlands
    Chembiochem 6:821-4. 2005
  9. ncbi Structural biology and chemistry of the terpenoid cyclases
    David W Christianson
    Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104 6323, USA
    Chem Rev 106:3412-42. 2006
  10. ncbi Side chain-to-side chain cyclization by click reaction
    Alexandra Le Chevalier Isaad
    Laboratory of Peptide and Protein Chemistry and Biology, Polo Scientifico e Tecnologico, University of Florence, I 50019 Sesto Fiorentino, Italy
    J Pept Sci 15:451-4. 2009

Detail Information

Publications359 found, 100 shown here

  1. pmc Extreme bendability of DNA less than 100 base pairs long revealed by single-molecule cyclization
    Reza Vafabakhsh
    Department of Physics, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Science 337:1097-101. 2012
    ..We developed a fluorescence-based, protein-free assay for studying the cyclization of single DNA molecules in real time...
  2. ncbi Palladium-catalyzed oxidative carbocyclization/arylation of enallenes
    Tuo Jiang
    Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE 10691, Stockholm, Sweden
    Org Lett 13:5838-41. 2011
    ..The reaction shows wide tolerance toward highly functionalized arylboronic acids and results in a cis addition of two carbon moieties to an olefin in good to excellent yields...
  3. ncbi Palladium-catalyzed oxidative diarylating carbocyclization of enynes
    Min Jiang
    Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE 106 91 Stockholm, Sweden
    Org Lett 14:3538-41. 2012
    ..Control experiments suggest that the reaction starts with an arylpalladation of the alkyne, followed by carbocyclization, transmetalation, and reductive elimination to afford the diarylated product...
  4. ncbi Effect of peptide fragment size on the propensity of cyclization in collision-induced dissociation: oligoglycine b(2)-b(8)
    Xian Chen
    Department of Chemistry, University of Florida, Gainesville, Florida 32611, USA
    J Am Chem Soc 131:18272-82. 2009
    ..This rearrangement mechanism is thought to be due to a head-to-tail cyclization reaction, where the N-terminal and C-terminal part of the fragment are fused into a macrocycle (= cyclic ..
  5. ncbi Cyclization reaction of peptide fragment ions during multistage collisionally activated decomposition: an inducement to lose internal amino-acid residues
    Chenxi Jia
    Chemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People s Republic of China
    J Am Soc Mass Spectrom 18:663-78. 2007
    ..The unique fragmentation consisting of multiple steps is induced by a cyclization reaction of b ions, the mechanism of which has been probed by experiments of N-acetylation, MS(n), rearranged-..
  6. ncbi Bioconjugation with strained alkenes and alkynes
    Marjoke F Debets
    Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ, The Netherlands
    Acc Chem Res 44:805-15. 2011
    ..In the search for bioorthogonal reactions, cycloadditions of cyclic alkenes and alkynes have now established themselves as powerful tools in reagent-free bioconjugations...
  7. ncbi A strain-promoted [3 + 2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems
    Nicholas J Agard
    Department of Chemistry, Howard Hughes Medical Institute, University of California, and Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Am Chem Soc 126:15046-7. 2004
    ..The utility of the reaction was demonstrated by selective modification of biomolecules in vitro and on living cells, with no apparent toxicity...
  8. ncbi Rapid and quantitative cyclization of multiple peptide loops onto synthetic scaffolds for structural mimicry of protein surfaces
    Peter Timmerman
    Pepscan Systems B V P O Box 2098, 8203 AB Lelystad, The Netherlands
    Chembiochem 6:821-4. 2005
  9. ncbi Structural biology and chemistry of the terpenoid cyclases
    David W Christianson
    Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104 6323, USA
    Chem Rev 106:3412-42. 2006
  10. ncbi Side chain-to-side chain cyclization by click reaction
    Alexandra Le Chevalier Isaad
    Laboratory of Peptide and Protein Chemistry and Biology, Polo Scientifico e Tecnologico, University of Florence, I 50019 Sesto Fiorentino, Italy
    J Pept Sci 15:451-4. 2009
    ..Herein, we provide a detailed protocol for the syntheses of model heterodetic cyclopeptides as a prototypical intramolecular CuAAC, using as a model a sequence derived from parathyroid hormone-related protein...
  11. pmc Cu-free click cycloaddition reactions in chemical biology
    John C Jewett
    Department of Chemistry, University of California, Berkeley, CA 94720, USA
    Chem Soc Rev 39:1272-9. 2010
    ..This tutorial review will summarize the history of this emerging field, as well as recent progress in the development and application of bioorthogonal copper-free click cycloaddition reactions...
  12. ncbi Cyclization of conotoxins to improve their biopharmaceutical properties
    Richard J Clark
    The University of Queensland, Institute for Molecular Bioscience, Brisbane, QLD 4072, Australia
    Toxicon 59:446-55. 2012
    ..article gives a brief background on conotoxins, describes their structures and highlights methods for synthetic cyclization to improve their biopharmaceutical properties...
  13. ncbi Cyclization and rearrangement reactions of a(n) fragment ions of protonated peptides
    Benjamin J Bythell
    Computational Proteomics Group, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    J Am Chem Soc 132:14766-79. 2010
    ..Overall, theory and infrared spectroscopy provide compelling evidence that a(n) ions undergo cyclization and/or rearrangement reactions, and the resulting structure(s) observed under our experimental conditions ..
  14. ncbi Stabilization of native protein fold by intein-mediated covalent cyclization
    Neal K Williams
    Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia
    J Mol Biol 346:1095-108. 2005
    ..coli DnaB helicase was used as a model system to assess the stabilization against unfolding gained by covalent cyclization. Cyclization was achieved in vivo by formation of an amide bond between the N and C termini with the help of a ..
  15. ncbi Chemical modifications designed to improve peptide stability: incorporation of non-natural amino acids, pseudo-peptide bonds, and cyclization
    Luca Gentilucci
    Department of Chemistry G Ciamician, Universita degli Studi di Bologna, Via Selmi 2, 40126 Bologna, Italy
    Curr Pharm Des 16:3185-203. 2010
    ..This review focuses on modified peptides in which the peptide character is still preponderant, with particular emphasis on the chemical methodologies utilized to introduce the modifications...
  16. pmc Marine molecular machines: heterocyclization in cyanobactin biosynthesis
    John A McIntosh
    Department of Medicinal Chemistry, College of Pharmacy, University of Utah, Salt Lake City, UT 84112 USA
    Chembiochem 11:1413-21. 2010
    ..The cyanobactin pathway enzymes, PatD and TruD, are thiazoline and oxazoline synthetases...
  17. ncbi Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines: indole synthesis from anilines and ketones
    Ye Wei
    Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, Singapore
    J Am Chem Soc 134:9098-101. 2012
    We report here an operationally simple, palladium-catalyzed cyclization reaction of N-aryl imines, affording indoles via the oxidative linkage of two C-H bonds under mild conditions using molecular oxygen as the sole oxidant...
  18. pmc Gold(I)-catalyzed coupling reactions for the synthesis of diverse small molecules using the build/couple/pair strategy
    Tuoping Luo
    Howard Hughes Medical Institute, Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    J Am Chem Soc 131:5667-74. 2009
    ..These pairing reactions include one based on a novel aza-Wittig-6pi-electrocyclization sequence and others based on ring-closing metathesis reactions...
  19. pmc Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38
    Richard Graeff
    Department of Physiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 284:27629-36. 2009
    ..This study provides the first detailed evidence of the cyclization process and demonstrates the feasibility of engineering the reactivity of the enzymes by mutation, setting the ..
  20. pmc Collective synthesis of natural products by means of organocascade catalysis
    Spencer B Jones
    Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, USA
    Nature 475:183-8. 2011
    ..The power of this concept has been demonstrated through the expedient, asymmetric total syntheses of six well-known alkaloid natural products: strychnine, aspidospermidine, vincadifformine, akuammicine, kopsanone and kopsinine...
  21. ncbi Synthesis of polysubstituted imidazo[1,2-a]pyridines via microwave-assisted one-pot cyclization/Suzuki coupling/palladium-catalyzed heteroarylation
    Jamal Koubachi
    Institut de Chimie Organique et Analytique, UMR CNRS 6005, Universite d Orleans, BP 6759, 45067 Orleans Cedex 2, France
    J Org Chem 72:7650-5. 2007
    ..derivatives using a microwave-assisted one-pot, two-step Suzuki/heteroarylation or one-pot, three-step cyclization/Suzuki/heteroarylation was developed...
  22. ncbi Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis
    Florian Kopp
    Fachbereich Chemie Biochemie, Philipps Universitat Marburg, Hans Meerwein Strasse, 35043, Marburg, Germany
    Nat Prod Rep 24:735-49. 2007
    ..Further, it is illustrated that macrocyclization is not restricted to secondary metabolites, but represents a commonly found structural motif of other biologically active proteins and peptides...
  23. ncbi Total synthesis of alpha-pyrone meroterpenoids, novel bioactive microbial metabolites
    Toshiaki Sunazuka
    Kitasato Institute for Life Sciences, Kitasato University, and The Kitasato Institute, Shirokane, Minato ku, Japan
    Chem Rev 105:4559-80. 2005
  24. ncbi Asymmetric synthesis of isoquinoline alkaloids
    Maria Chrzanowska
    Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60 780 Poznan, Poland
    Chem Rev 104:3341-70. 2004
  25. ncbi On the origins of triterpenoid skeletal diversity
    Ran Xu
    Department of Chemistry, Rice University, 6100 S Main Street, Houston, TX 77005, USA
    Phytochemistry 65:261-91. 2004
    ..skeletons are known from natural sources or enzymatic reactions that are structurally consistent with being cyclization products of squalene, oxidosqualene, or bis-oxidosqualene...
  26. ncbi Biosynthetic diversity in plant triterpene cyclization
    Dereth R Phillips
    Department of Biochemistry and Cell Biology and Department of Chemistry, Rice University, 6100 Main Street, Houston, TX 77005, USA
    Curr Opin Plant Biol 9:305-14. 2006
    ..By contrast, the phylogenetic relationships of cyclases that generate nonsteroidal triterpene alcohols do not consistently reflect their catalytic properties and might indicate recent and rapid catalytic evolution...
  27. ncbi Structural determinants for N1/N7 cyclization of nicotinamide hypoxanthine 5'-dinucleotide (NHD+) derivatives by ADP-ribosyl cyclase from aplysia californica: Ca2+-mobilizing activity of 8-substituted cyclic inosine 5'-diphosphoribose analogues in T-lymph
    Christelle Moreau
    Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, United Kingdom
    J Med Chem 49:5162-76. 2006
    ..hypoxanthine 5'-dinucleotide (NHD+) analogues modified at C-8 (2-5) and 7-deaza-NHD+ were synthesized, and cyclization in the presence of Aplysia ADP-ribosyl cyclase was studied...
  28. ncbi Microwave-assisted syntheses of N-heterocycles using alkenone-, alkynone- and aryl-carbonyl O-phenyl oximes: formal synthesis of neocryptolepine
    Fernando Portela-Cubillo
    School of Chemistry, EaStCHEM, University of St Andrews, St Andrews, Fife KY16 9ST, UK
    J Org Chem 73:5558-65. 2008
    ..However, iminyl radicals did cyclize onto indoles, enabling indolopyridines to be prepared. The latter route was exploited in a short formal synthesis of neocryptolepine starting from 2-((1H-indol-3-yl)methyl)cyclohexanone...
  29. ncbi Antioxidant activity of the anti-inflammatory compound ebselen: a reversible cyclization pathway via selenenic and seleninic acid intermediates
    Bani Kanta Sarma
    Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560 012, India
    Chemistry 14:10603-14. 2008
    ..the concentration of the thiol is relatively low in the reaction mixture, the selenenic acid undergoes a rapid cyclization to produce ebselen...
  30. ncbi Orchestration of discoid polyketide cyclization in the resistomycin pathway
    Kathrin Fritzsche
    Leibniz Institute for Natural Product Research and Infection Biology, HKI, Department of Biomolecular Chemistry, Beutenbergstr 11a, 07745 Jena, Germany
    J Am Chem Soc 130:8307-16. 2008
    ..In total three cyclases that are involved in discoid cyclization (RemI, RemF, and RemL) were identified by mutational analyses and in vivo pathway reconstitution...
  31. pmc Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates
    Joseph P Noel
    Howard Hughes Medical Institute, USA
    ACS Chem Biol 5:377-92. 2010
    ..originates from the enzyme-catalyzed ionization of (trans,trans)-farnesyl diphosphate (FPP) (1a) and subsequent cyclization along either 2,3-transoid or 2,3-cisoid farnesyl cation pathways...
  32. ncbi Cyclization of hydrazones of 2-acetyl-1-naphthol and 1-acetyl-2-naphthol with triphosgene. Synthesis of Spiro naphthoxazine dimers
    Abdullah Saad Al-Bogami
    Department of Chemistry, King Saud University, P O Box 2455, Riyadh 11451, Saudi Arabia
    Molecules 14:2147-59. 2009
    b>Cyclization of hydrazones derived from 2-acetyl-1-naphthol and 1-acetyl-2-naphthol with triphosgene gave naphtho[1,2-e]-1,3-oxazines, naphtho[2,1-e]-1,3-oxazines or their spiro dimers depending on the molar ratio of triphosgene used for ..
  33. pmc Spectroscopic, steady-state kinetic, and mechanistic characterization of the radical SAM enzyme QueE, which catalyzes a complex cyclization reaction in the biosynthesis of 7-deazapurines
    Reid M McCarty
    Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ 85721, USA
    Biochemistry 52:188-98. 2013
    ..These studies implicate 5'-dAdo(•) as the initiator of the ring contraction reaction catalyzed by QueE by abstraction of the H atom from C-6 of CPH(4)...
  34. pmc Design and synthesis of medium-ring lactam libraries inspired by octalactin a. A convergent-divergent approach
    Neil Brown
    Department of Chemistry, University of Missouri, 205 Spencer Chemical Laboratories, 5100 Rockhill Road, Kansas City, Missouri 64110, USA
    J Comb Chem 10:628-31. 2008
  35. pmc Structure-activity relationship and metabolic stability studies of backbone cyclization and N-methylation of melanocortin peptides
    Yaniv Linde
    Institute of Chemistry, Safra Campus, Givat Ram, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Biopolymers 90:671-82. 2008
    Backbone cyclization (BC) and N-methylation have been shown to enhance the activity and/or selectivity of biologically active peptides and improve metabolic stability and intestinal permeability...
  36. ncbi Total synthesis of the aspercyclides
    Jiří Pospíšil
    Max Planck Institut fur Kohlenforschung, 45470 Mulheim Ruhr, Germany
    Chemistry 15:5956-68. 2009
    ..The preparation of the required cyclization precursor 43 hinged on a palladium-catalyzed ortho-iodination reaction of 2-methylbenzoic acid, an efficient ..
  37. pmc Palladium(II)-catalyzed cyclization of unsaturated hydroperoxides for the synthesis of 1,2-dioxanes
    Jason R Harris
    Department of Chemistry, University of California, Irvine, California 92697 2025, USA
    Org Lett 11:3290-3. 2009
    The cyclization of gamma,delta-unsaturated tertiary hydroperoxides in the presence of a palladium(II) catalyst afforded 1,2-dioxanes resembling biologically active natural products...
  38. ncbi Reactivity and regioselectivity in 1,3-dipolar cycloadditions of azides to strained alkynes and alkenes: a computational study
    Franziska Schoenebeck
    Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA
    J Am Chem Soc 131:8121-33. 2009
    ..Trans-cycloalkene dipolarophiles have much lower barriers than cis-cycloalkenes...
  39. pmc X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate
    Ekaterina Y Shishova
    Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6323, USA
    Biochemistry 46:1941-51. 2007
    Aristolochene synthase from Aspergillus terreus catalyzes the cyclization of the universal sesquiterpene precursor, farnesyl diphosphate, to form the bicyclic hydrocarbon aristolochene. The 2...
  40. ncbi Chemical synthesis, backbone cyclization and oxidative folding of cystine-knot peptides: promising scaffolds for applications in drug design
    Michael Reinwarth
    Institute for Organic Chemistry and Biochemistry, Technische Universitat Darmstadt, Darmstadt, Germany
    Molecules 17:12533-52. 2012
    ..residues), the chemical synthesis route is challenging since it involves critical steps such as head-to-tail cyclization and oxidative folding towards the respective bioactive isomer...
  41. ncbi Tetrasubstituted 2-imidazolones via Ag(I)-catalyzed cycloisomerization of propargylic ureas
    Vsevolod A Peshkov
    Laboratory for Organic and Microwave Assisted Chemistry LOMAC, Department of Chemistry, Katholieke Universiteit Leuven, Leuven, Belgium
    J Org Chem 76:5867-72. 2011
    ..A one-pot protocol based on a Ag(I)-catalyzed cycloisomerization of propargylic ureas, derived from secondary propargylamines and isocyanates, was developed for the generation of the 2-imidazolone core...
  42. ncbi Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA(B) receptor
    Reena Halai
    Institute for Molecular Bioscience, Division of Chemistry and Structural Biology, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Med Chem 54:6984-92. 2011
    ..Here, we improved the biopharmaceutical properties of RgIA by backbone cyclization using 3-7 residue peptidic linkers...
  43. ncbi Reductive cyclization cascades of lactones using SmI2-H2O
    Dixit Parmar
    School of Chemistry, University of Manchester, Manchester, United Kingdom
    J Am Chem Soc 133:2418-20. 2011
    Lactones bearing two alkenes or an alkene and an alkyne undergo reductive cyclization cascades upon treatment with SmI(2)-H(2)O, giving decorated azulene motifs in excellent yields with good diastereocontrol.
  44. ncbi Cysteine cyclic pyrrole-imidazole polyamide for sequence-specific recognition in the DNA minor groove
    Hironobu Morinaga
    Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606 8502, Japan
    J Am Chem Soc 133:18924-30. 2011
    ..Here, we describe a novel cyclization method for producing PI polyamides using cysteine and a chloroacetyl residue...
  45. ncbi Selective transition state stabilization via hyperconjugative and conjugative assistance: stereoelectronic concept for copper-free click chemistry
    BRIAN GOLD
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306 4390, USA
    J Org Chem 77:75-89. 2012
    ..Further computational and experimental studies confirmed the generality of the above accelerating effects and compared them with the conjugative TS stabilization by π-acceptors...
  46. pmc Insights into diterpene cyclization from structure of bifunctional abietadiene synthase from Abies grandis
    Ke Zhou
    Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA
    J Biol Chem 287:6840-50. 2012
    ..for diterpene synthase activity, catalyzing class I (ionization-initiated) and class II (protonation-initiated) cyclization reactions. Reported here is the crystal structure of AgAS at 2...
  47. pmc Aberrant cyclization affords a C-6 modified cyclic adenosine 5'-diphosphoribose analogue with biological activity in Jurkat T cells
    Christelle Moreau
    Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, United Kingdom
    J Med Chem 55:1478-89. 2012
    ....
  48. ncbi Tandem Rh(III)-catalyzed oxidative acylation of secondary benzamides with aldehydes and intramolecular cyclization: the direct synthesis of 3-hydroxyisoindolin-1-ones
    Satyasheel Sharma
    Department of Chemistry, University of Ulsan, Ulsan, 680 749, Republic of Korea
    Org Lett 14:906-9. 2012
    ..between secondary benzamides and aryl aldehydes via sp(2) C-H bond activation followed by an intramolecular cyclization is described...
  49. pmc A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion
    Felix Kopp
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Chem Biol 8:358-65. 2012
    ..Cheminformatic analysis indicates that these macrocycles access regions of chemical space that overlap with natural products, distinct from currently targeted synthetic drugs...
  50. ncbi Identification and characterization of xiamycin A and oxiamycin gene cluster reveals an oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis
    Huixian Li
    CAS Key Laboratory of Marine Bio resources Sustainable Utilization, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China
    J Am Chem Soc 134:8996-9005. 2012
    ..Most notably, the flavin dependent oxygenase XiaI was biochemically characterized in vitro to convert indosespene to XMA, revealing an unusual oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis.
  51. pmc Cyclization of the intrinsically disordered α1S dihydropyridine receptor II-III loop enhances secondary structure and in vitro function
    Han Shen Tae
    John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, Australian Capital Territory 2601, Australia
    J Biol Chem 286:22589-99. 2011
    ..RyR1) increased 4-fold, and its ability to activate RyR1 channels in lipid bilayers was enhanced 3-fold by cyclization. These functional changes were predicted consequences of the structural enhancement...
  52. ncbi Aza-1,2,3-triazole-3-alanine synthesis via copper-catalyzed 1,3-dipolar cycloaddition on aza-progargylglycine
    Caroline Proulx
    Departement de Chimie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec H3C 3J7, Canada
    J Org Chem 75:5385-7. 2010
    ..Circular dichroism spectroscopy in water demonstrated that azapeptides which possess an aza-1,2,3-triazole-3-alanine residue at the Trp(4) position of the GHRP-6 sequence adopt beta-turn conformations...
  53. ncbi Effect of the His residue on the cyclization of b ions
    Benjamin J Bythell
    Computational Proteomics Group, German Cancer Research Center DKFZ, Heidelberg, Germany
    J Am Soc Mass Spectrom 21:1352-63. 2010
    ..There is compelling experimental and theoretical evidence for formation of nondirect sequence ions via cyclization/reopening chemistry in the CID spectra of the b ions when the His residue is near the C-terminus...
  54. ncbi One-pot cyclization of 2-aminophenethyl alcohols: a novel and direct approach to the synthesis of N-acyl indolines
    Zengxue Wang
    Department of Chemistry, Shanghai University, Shanghai, China
    J Org Chem 72:9364-7. 2007
    A unique one-pot cyclization of 2-aminophenethyl alcohols with carboxylic acids in the presence of PPh3, CCl4, and NEt3 furnished the formation of N-acyl indolines in good to excellent yields...
  55. pmc Total synthesis of the strychnos alkaloid (+)-minfiensine: tandem enantioselective intramolecular Heck-iminium ion cyclization
    Amy B Dounay
    Department of Chemistry, University of California, Irvine, 1102 Natural Sciences II, Irvine, California 92697 2025, USA
    J Am Chem Soc 130:5368-77. 2008
    ..A cascade catalytic asymmetric Heck-iminium cyclization was developed that rapidly provides 3,4-dihydro-9a,4a-(iminoethano)-9H-carbazoles in high enantiomeric purity...
  56. pmc Reaction discovery employing macrocycles: transannular cyclizations of macrocyclic bis-lactams
    Chong Han
    Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA
    Org Lett 11:413-6. 2009
    ..Preliminary mechanistic studies support an olefin isomerization-intramolecular conjugate addition pathway...
  57. pmc Skeletal diversity via cationic rearrangements of substituted dihydropyrans
    Matthew R Medeiros
    Department of Chemistry, Center for Chemical Methodology and Library Development CMLD BU, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA
    Org Lett 12:3222-5. 2010
    ..Substituted dihydropyrans, easily accessed from a commercially available glycal, undergo acid-catalyzed rearrangement to provide highly functionalized isochroman and dioxabicyclooctane scaffolds...
  58. pmc Highly Z- and enantioselective ring-opening/cross-metathesis reactions catalyzed by stereogenic-at-Mo adamantylimido complexes
    Ismail Ibrahem
    Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
    J Am Chem Soc 131:3844-5. 2009
    ..Importantly, the desired chiral pyrans thus obtained bear a Z olefin either exclusively (>98:<2 Z/E) or predominantly (>or=87:13 Z/E)...
  59. ncbi Improved proteolytic stability of chicken cathelicidin-2 derived peptides by D-amino acid substitutions and cyclization
    E Margo Molhoek
    TNO Defense, Security and Safety, Rijswijk, The Netherlands
    Peptides 32:875-80. 2011
    ..we engineered novel chicken cathelicidin-2 analogs by substitution of l- with D-amino acids and head-to-tail cyclization. Both cyclic and D-amino acid variants showed enhanced stability in human serum compared to C1-15 and F(2,5,12)..
  60. ncbi First determination of the rate constant for ring-closure of an azahexenoyl radical: 6-aza-7-ethyl-5-hexenoyl
    Sara H Kyne
    ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, Australia
    Chem Commun (Camb) 46:6521-3. 2010
    ..utilising free radical carbonylation chemistry provide a first estimate for the rate constant for 6-endo cyclization of the 6-aza-7-ethyl-5-hexenoyl radical of (4.8 +/- 2...
  61. ncbi (5'S)- and (5'R)-5',8-cyclo-2'-deoxyguanosine: mechanistic insights on the 2'-deoxyguanosin-5'-yl radical cyclization
    Chryssostomos Chatgilialoglu
    ISOF, Consiglio Nazionale delle Ricerche, Bologna, Italy
    Chem Res Toxicol 20:1820-4. 2007
    ..The observed (5'R)/(5'S) ratio of 8:1 was obtained in both sets of experiments. The mechanism of the cyclization reaction is discussed in some detail, and the diastereomeric outcome is rationalized in terms of favorable ..
  62. ncbi Synthesis of novel peptide linkers: simultaneous cyclization and labeling
    Gajanan K Dewkar
    Department of Chemistry and Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, Virginia 23298 0037, USA
    Org Lett 11:4708-11. 2009
    ..These reagents can be used to simultaneously cyclize and label peptides containing two cysteines. Many labels are compatible with this method including lipids, fluorescent groups, and biotin...
  63. ncbi Template effects in S(N)2 displacements for the preparation of pseudopeptidic macrocycles
    Vicente Martí-Centelles
    Departament de Quimica Inorganica i Organica, Universitat Jaume I 12071 Castelló, Spain
    Chemistry 18:2409-22. 2012
    ..Interestingly, the presence of different substituents on the constituent amino acids seems to play a minor role in the overall process...
  64. ncbi The remarkable metal-catalysed olefin metathesis reaction
    Amir H Hoveyda
    Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Nature 450:243-51. 2007
    ..Nonetheless, the full potential of olefin metathesis will be realized only when additional catalysts are discovered that are truly practical and afford exceptional selectivity for a significantly broader range of reactions...
  65. ncbi A regioselective approach to trisubstituted 2 (or 6)-arylaminopyrimidine-5-carbaldehydes and their application in the synthesis of structurally and electronically unique GlambdaC base precursors
    Rachel L Beingessner
    National Institute for Nanotechnology and Department of Chemistry, University of Alberta, 11421 Saskatchewan Drive, Edmonton, Alberta, T6G 2M9, Canada
    J Org Chem 73:931-9. 2008
    ..Furthermore, these fused-bicyclic compounds are readily derivatized using the Suzuki cross-coupling reaction to generate electronically and structurally unique GlambdaC base precursors...
  66. pmc Synthesis of unique scaffolds via Diels-Alder cycloadditions of tetrasubstituted cyclohexadienes
    Amanda L Jones
    Department of Chemistry and the Center for Chemical Methodology and Library Development CMLD BU, Boston University, Boston, Massachusetts 02215, USA
    Org Lett 12:1592-5. 2010
    ..Reactive heterodienophiles, including singlet oxygen ((1)O(2)), 4-substituted-1,2,4-triazoline-3,5-diones (TADs), and aryl- and acylnitroso compounds were employed, yielding novel heterocyclic products...
  67. ncbi Gold(I)-catalyzed regioselective cyclizations of silyl ketene amides and carbamates with alkynes
    Ellen C Minnihan
    Department of Medicinal Chemistry, Merck Research Laboratories, Merck and Co Inc, P O Box 2000, Rahway, NJ 07065, USA
    J Org Chem 72:6287-9. 2007
    ..The gold(I)-catalyzed regioselective cyclizations of silyl ketene amides or carbamates with alkynes were utilized to construct cyclopentanes or dehydro-delta-lactams...
  68. ncbi Conversion of squalene to the pentacarbocyclic hopene
    Dirk J Reinert
    Institut fur Organische Chemie und Biochemie, Albert Ludwigs Universitat, Albertstr 21, D 79104 Freiburg, Germany
    Chem Biol 11:121-6. 2004
    ..The structure analysis revealed a mobile region between the active center cavity and the membrane, which may melt, opening a passage for squalene and hopene...
  69. ncbi Synthesis of (-)-conocarpan by two routes based on radical cyclization and establishment of its absolute configuration
    Derrick L J Clive
    Chemistry Department, University of Alberta, Edmonton, Alberta T6G 2G2, Canada
    Org Biomol Chem 6:1831-42. 2008
    ..The first (98% ee) is based on formal radical cyclization onto a benzene ring, and involves a 5-exo-trigonal closure onto a double bond restrained within a 6-membered ..
  70. ncbi Synthesis of novel 3-(aryl)benzothieno[2,3-c]pyran-1-ones from Sonogashira products and intramolecular cyclization: Antitumoral activity evaluation
    Maria João R P Queiroz
    Centro de Quimica, Universidade do Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Eur J Med Chem 44:1893-9. 2009
    ..tricyclic lactones) were prepared either by a tandem one-pot Sonogashira coupling and intramolecular cyclization, reacting the 3-bromobenzo[b]thiophene-2-carboxylic acid with arylacetylenes, or by Sonogashira coupling of the ..
  71. ncbi Non-enzymatic cyclization of creatine ethyl ester to creatinine
    Matthew W Giese
    Department of Chemistry, Marian University, Indianapolis, IN 46222, USA
    Biochem Biophys Res Commun 388:252-5. 2009
    ..It was found that mild aqueous conditions result in the cyclization of creatine ethyl ester to provide inactive creatinine as the exclusive product, and this transformation ..
  72. ncbi Gold-catalyzed synthesis of carbon-bridged medium-sized rings
    Francis Barabé
    Center for Catalysis Research and Innovation, University of Ottawa, Department of Chemistry, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5
    Org Lett 11:4236-8. 2009
    ..Herein, we report a mild and highly efficient method to generate carbon-bridged frameworks of various sizes using phosphino gold(I) catalysts...
  73. ncbi Highly efficient Cu(I)-catalyzed synthesis of N-heterocycles through a cyclization-triggered addition of alkynes
    Junbin Han
    Department of Chemistry, University of Louisville, Louisville, Kentucky 40292, USA
    J Am Chem Soc 132:916-7. 2010
    ..An aminoalkyne (terminal or internal) and a terminal alkyne furnish functionalized five-, six-, and seven-membered N-heterocycles in excellent yields via a Cu(I)-catalyzed, one-pot, tandem hydroamination/alkynylation process...
  74. ncbi Gold(I)-catalyzed tandem cyclization approach to tetracyclic indolines
    Yongxiang Liu
    Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, USA
    Org Lett 12:1448-51. 2010
    Two highly stereoselective cationic gold(I)-catalyzed tandem cyclization reactions of alkynylindoles are described. These reactions demonstrated a novel and general strategy to rapidly construct highly functionalized polycyclic indolines...
  75. pmc Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers
    Fernando Lopez-Gallego
    Department of Biochemistry, University of Minnesota, Paul, MN 55108, USA
    Chembiochem 11:1093-106. 2010
    Sesquiterpene synthases catalyze with different catalytic fidelity the cyclization of farnesyl pyrophosphate (FPP) into hundreds of known compounds with diverse structures and stereochemistries...
  76. ncbi Azaanthraquinone assembly from N-propargylamino quinone via a Au(I)-catalyzed 6-endo-dig cycloisomerization
    Chunhui Jiang
    School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, P R China
    J Org Chem 75:4323-5. 2010
    ..The catalytic process was applied to the synthesis of alkaloid cleistopholine and its analogues. A mechanism involving benign nucleophilicity of the aminoquinone was proposed...
  77. pmc Genetic interception and structural characterization of thiopeptide cyclization precursors from Bacillus cereus
    Albert A Bowers
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Chem Soc 132:12182-4. 2010
    ..These results identify TclM and its homologues in other thiazolyl peptide producing strains as the enzymes responsible for the trans-annular heteroannulation at core of this class of molecules...
  78. ncbi Radiolytic cyclization of stem-and-loop structured oligodeoxynucleotide with neighboring arrangement of α,ω-bis-disulfides
    Kazuhito Tanabe
    Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615 8510, Japan
    Org Biomol Chem 8:4837-42. 2010
    ..that forms a stem-and-loop structure with a neighboring arrangement of α,ω-bis-disulfides underwent efficient cyclization via an intramolecular exchange reaction at the disulfide moieties with a multiple turnover process...
  79. pmc Total synthesis and antimicrobial activity of a natural cycloheptapeptide of marine origin
    Rajiv Dahiya
    Department of Pharmaceutical Chemistry, NRI Institute of Pharmacy, Bhopal 462 021, Madhya Pradesh, India
    Mar Drugs 8:2384-94. 2010
    ..Boc-L-Pro-L-Ile-L-Pro-OH tripeptide unit with the L-Phe-L-Pro-L-Pro-L-Tyr-OMe tetrapeptide unit, followed by cyclization of the resulting linear heptapeptide fragment...
  80. ncbi Molecular mechanism of enzymatic allene oxide cyclization in plants
    Eckhard Hofmann
    Biophysics, Department of Biology and Biotechnology, Ruhr University Bochum, Universitaetsstrasse 150, D 44801 Bochum, Germany
    Plant Physiol Biochem 46:302-8. 2008
    ..the first oxylipin with signal character, cis-(+)-12-oxo-phytodienoic acid (OPDA), is produced in a cyclization reaction catalyzed by allene oxide cyclase (AOC)...
  81. ncbi Rhodium-catalyzed synthesis of eight-membered rings
    Brenton DeBoef
    Department of Chemistry, Washington University, One Brookings Drive, Saint Louis, Missouri 63130 4899, USA
    J Org Chem 72:799-804. 2007
    ..A catalyst system that provides cyclooctatrienes in greater than 70% yield is reported. Several experiments to determine the nature of the catalyst are described...
  82. pmc Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity
    Moushumi Paul
    Department of Chemistry, University of Illinois at Urbana Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
    Biochemistry 46:6268-76. 2007
    ..However, these mutations compromised cyclization activity when investigated with full length or truncated peptide substrates...
  83. ncbi Novel approach to 5-substituted proline derivatives using a silver-catalyzed cyclization as the key step
    Bart C J van Esseveldt
    Radboud University Nijmegen, Institute for Molecules and Materials, Toernooiveld 1, NL 6525 ED Nijmegen, The Netherlands
    J Org Chem 70:1791-5. 2005
    ..The methodology involves a Ag-catalyzed 5-endo-dig cyclization of enantiopure aryl-substituted acetylene-containing amino acids...
  84. ncbi Intein-mediated cyclization of a soluble and a membrane protein in vivo: function and stability
    Christian Siebold
    Departement fur Chemie und Biochemie, Universitat Bern, Bern, Switzerland
    Biophys Chem 96:163-71. 2002
    ..Cyclized IIA(Glc) displayed increased stability against temperature and GuHCl-induced unfolding (75 vs. 70 degrees C; 1.52 vs. 1.05 M)...
  85. ncbi Extending Pummerer reaction chemistry. development of a strategy for the regio- and stereoselective oxidative cyclization of 3-(omega-nucleophile)-tethered indoles
    Ken S Feldman
    Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Org Chem 70:6429-40. 2005
    The brominative cyclization of diastereomeric beta-silyloxy tryptophan derivatives proceeded with divergent regiochemistry (C(2) or C(3) addition), depending on the relative stereochemistry of the silyloxy substituent...
  86. ncbi An effective use of benzoic anhydride and its derivatives for the synthesis of carboxylic esters and lactones: a powerful and convenient mixed anhydride method promoted by basic catalysts
    Isamu Shiina
    Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku ku, Tokyo 162 8601, Japan
    J Org Chem 69:1822-30. 2004
    ..The efficiency of the cyclizations is compared to those of other reported lactonizations...
  87. ncbi Stereochemical diversity through cyclodimerization: synthesis of polyketide-like macrodiolides
    Qibin Su
    Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA
    Org Lett 5:2149-52. 2003
    ..Additional structural diversity is introduced by further stereoselective reactions on selected macrodiolides 7a, 7g, 10a, and 11...
  88. ncbi Practical solid-phase parallel synthesis of Delta(5)-2-oxopiperazines via N-acyliminium ion cyclization
    Sung Chan Lee
    Department of Chemistry, Seoul National University, Seoul 151 747, Korea
    J Comb Chem 9:828-35. 2007
    A practical solid-phase strategy for the synthesis of Delta(5)-2-oxopiperazines via N-acyliminium ion cyclization has been developed...
  89. ncbi Loading peptidyl-coenzyme A onto peptidyl carrier proteins: a novel approach in characterizing macrocyclization by thioesterase domains
    Stephan A Sieber
    Fachbereich Chemie Biochemie, Philipps Univerität Marburg, Hans Meerwein Strasse, 35032 Marburg, Germany
    J Am Chem Soc 125:10862-6. 2003
    ..To explore the great potential of these domains for the catalysis of cell-free cyclization reactions, the new strategy takes advantage of the direct interaction between the natural substrate where the ..
  90. pmc Second-generation difluorinated cyclooctynes for copper-free click chemistry
    Julian A Codelli
    Departments of Chemistry, University of California, Berkeley, California 94720, USA
    J Am Chem Soc 130:11486-93. 2008
    ..These second-generation DIFO reagents should expand the use of copper-free click chemistry in the hands of biologists...
  91. ncbi Effective, selective hydroalkoxylation/cyclization of alkynyl and allenyl alcohols mediated by lanthanide catalysts
    Xianghua Yu
    Department of Chemistry, Northwestern University, Evanston, Illinois 60208, USA
    J Am Chem Soc 129:7244-5. 2007
  92. ncbi Elongated multiple electronic cascade and cyclization spacer systems in activatible anticancer prodrugs for enhanced drug release
    F M de Groot
    Department of Organic Chemistry, NSR-Center for Molecular Structure, Design and Synthesis, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    J Org Chem 66:8815-30. 2001
    ..It is expected that the generally applicable novel spacer systems reported herein will contribute to future development of improved enzymatically activated prodrugs...
  93. ncbi Asymmetric synthesis of tetrahydropalmatine via tandem 1,2-addition/cyclization
    Marine Boudou
    Institut fur Organische Chemie, RWTH Aachen, Landoltweg 1, D 52074 Aachen, Germany
    J Org Chem 70:9486-94. 2005
    ..The Pummerer cyclization led to the formation of (S)-(-)-2 with slight racemization (ee = 89%), whereas the Friedel-Crafts reaction ..
  94. ncbi Regiocontrolled intramolecular cyclizations of carboxylic acids to carbon-carbon triple bonds promoted by acid or base catalyst
    Masanobu Uchiyama
    Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba ku, Sendai 980 8578, Japan
    Org Lett 8:5517-20. 2006
    ..investigated, for the first time, the relationship between regioselectivity and acid/base effects in the cyclization reactions between carboxylic acids and carbon-carbon triple bonds...
  95. ncbi Unnatural natural products from the transannular cyclization of lathyrane diterpenes
    G Appendino
    Universita del Piemonte Orientale, DiSCAFF, Viale Ferrucci 33, 28100 Novara, Italy
    Org Lett 3:1609-12. 2001
    ..Apparently, Nature is far from having fully exploited the built-in reactivity of these compounds to generate chemical diversity...
  96. ncbi HPLC-MS characterization of cyclo-statherin Q-37, a specific cyclization product of human salivary statherin generated by transglutaminase 2
    Tiziana Cabras
    Department of Sciences Applied to Biosystems, Cagliari University, Monserrato Campus, Monserrato, CA, Italy
    J Sep Sci 29:2600-8. 2006
    ..Y, monitored by HPLC-electrospray ionization-ion trap-mass spectrometric analysis, demonstrated that cyclization involved almost specifically Gln-37 (> 95%), with the percentage of Gln-39 implicated in the cross-linkiing ..
  97. ncbi Serine and threonine beta-lactones: a new class of hepatitis A virus 3C cysteine proteinase inhibitors
    Manjinder S Lall
    Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2
    J Org Chem 67:1536-47. 2002
    ....
  98. pmc Scope and mechanistic study of the ruthenium-catalyzed ortho-C-H bond activation and cyclization reactions of arylamines with terminal alkynes
    Chae S Yi
    Department of Chemistry, Marquette University, Milwaukee, Wisconsin 53201 1881, USA
    J Am Chem Soc 127:17000-6. 2005
    ..A mechanism involving rate-determining ortho-C-H bond activation and intramolecular C-N bond formation steps via an unsaturated cationic ruthenium acetylide complex has been proposed...
  99. ncbi Microbial transformations of chalcones: hydroxylation, O-demethylation, and cyclization to flavanones
    M Sanchez-Gonzalez
    Division of Medicinal and Natural Products Chemistry, Center for Biocatalysis and Bioprocessing, College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, USA
    J Nat Prod 67:553-8. 2004
    ..flavanones and to O-demethylated and hydroxylated chalcones, some of which functioned as intermediates in the cyclization process...
  100. ncbi Efficient macrocyclization of U-turn preorganized peptidomimetics: the role of intramolecular H-bond and solvophobic effects
    Jorge Becerril
    Department of Inorganic and Organic Chemistry, University Jaume, I E 12080 Castellón, Spain
    J Am Chem Soc 125:6677-86. 2003
    ..The cyclization reaction does not require high dilution techniques and seems to be insensitive to the size of the formed ..
  101. ncbi Quantitative analysis, using MALDI-TOF mass spectrometry, of the N-terminal hydrolysis and cyclization reactions of the activation process of onconase
    Marc Ribo
    Laboratori d Enginyeria de Proteïnes, Departament de Biologia, Facultat de Ciencies, Universitat de Girona, Girona, Spain
    Eur J Biochem 271:1163-71. 2004
    ..0. The intramolecular cyclization of glutaminyl that renders the pyroglutamyl residue is not accelerated by increasing the concentration of ..

Research Grants10

  1. Analogs of GTP as novel inhibitors of bacterial c-di-GMP-synthesizing enzymes
    George E Wright; Fiscal Year: 2010
    ..chromatography, and characterized by NMR and LCMS methods;2, test GTP analogs for their ability to inhibit cyclization of GTP to c-di- GMP by the Pseudomonas aeruginosa DGC "PA3702";a coupled assay measuring pyrophosphate release ..
  2. Synthesis of Medicinally Important Heterocycles
    RICHARD LAROCK; Fiscal Year: 2007
    The vast majority of medicinally important drugs contain a heterocyclic or carbocyclic ring. The electrophilic cyclization of functionally-substituted alkynes has been little studied, although it would appear to be a very promising route ..
  3. REACTIVITY MODELS FOR ISOPENICILLIN N SYNTHETASE
    PATRICIA SHAPLEY; Fiscal Year: 1992
    ..biosynthesis of both penicillins and cephalosporins, a small, soluble enzyme is responsible for the oxidative cyclization of the tripeptide delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to isopenicillin N...
  4. DNA Topology In TBP/DNA Complexes: Chromatin Connections
    Jason Kahn; Fiscal Year: 2004
    ..to Pol II transcription initiation as part of the TFIID assembly, induces negative supercoiling upon DNA cyclization of short restriction fragments to give minicircies...
  5. TERPENE CYCLASES: FUNCTIONAL DOMAINS AND STRUCTURES
    JOSEPH NOEL; Fiscal Year: 2003
    The objective of this proposal is to understand the structural and mechanistic features governing the cyclization of farnesyl diphosphate (FPP) catalyzed by a homologous set of four plant sesquiterpene cyclases including Nictotiana ..
  6. FUNGAL POLYKETIDE SYNTHASES
    CHARLES SIH; Fiscal Year: 2001
    ..to catalyze the assembly of two distinct products with different carbon chain lengths, functionalization and cyclization patterns...
  7. MANGANESE (III) BASED OXIDATIVE FREE RADICAL CYCLIZATION
    BARRY SNIDER; Fiscal Year: 2000
    ..The goal of this research is to develop oxidative free- radical cyclization into a reliable and versatile method for the synthesis of highly functionalized cyclic and polycyclic compounds...
  8. CD38/ADP RIBOSYL CYCLASE R0LE IN OSTEOCLAST REGULATION
    Mone Zaidi; Fiscal Year: 2003
    ..The latter is formed from NAD+ following its cyclization by the enzyme, CD38 (an ADP-ribosyl cyclase)...
  9. Tetrahydrofurans, Tetrahydropyrans and 2H-Furanones
    CHRISTOPHER SPILLING; Fiscal Year: 2009
    ..Since the palladium catalyzed cyclization is stereospecific, the stereochemistry of the phosphono allylic carbonates dictates the stereochemistry of new ..
  10. A Bacitracin derivative for systemic use
    Ake Elhammer; Fiscal Year: 2007
    ..The CES approach combines automated solid-phase peptide synthesis of linear precursor peptides, with enzymatic cyclization using a recombinant thioesterase (TE) domain derived from the relevant Non Ribosomal Peptide Synthetase (NRPS) ..