acetylation

Summary

Summary: Formation of an acetyl derivative. (Stedman, 25th ed)

Top Publications

  1. pmc Combinatorial patterns of histone acetylations and methylations in the human genome
    Zhibin Wang
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 40:897-903. 2008
  2. ncbi Lysine acetylation targets protein complexes and co-regulates major cellular functions
    Chunaram Choudhary
    Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried, Germany
    Science 325:834-40. 2009
  3. ncbi Translating the histone code
    T Jenuwein
    Research Institute of Molecular Pathology IMP at the Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Science 293:1074-80. 2001
  4. pmc Regulation of cellular metabolism by protein lysine acetylation
    Shimin Zhao
    School of Life Sciences, Fudan University, Shanghai 20032, China
    Science 327:1000-4. 2010
  5. ncbi Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    Konrad T Howitz
    BIOMOL Research Laboratories, Inc, 5120 Butler Pike, Plymouth Meeting, Pennsylvania 19462, USA
    Nature 425:191-6. 2003
  6. ncbi Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    Anne Brunet
    Division of Neuroscience, Children s Hospital, and Department of Neurobiology, Center for Blood Research CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Science 303:2011-5. 2004
  7. ncbi Resveratrol improves health and survival of mice on a high-calorie diet
    Joseph A Baur
    Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 444:337-42. 2006
  8. ncbi HDAC6 is a microtubule-associated deacetylase
    Charlotte Hubbert
    Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710, USA
    Nature 417:455-8. 2002
  9. pmc Histone deacetylases (HDACs): characterization of the classical HDAC family
    Annemieke J M de Ruijter
    Academic Medical Centre, University of Amsterdam, Amsterdam, The, Netherlands
    Biochem J 370:737-49. 2003
  10. pmc AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
    Carles Canto
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Nature 458:1056-60. 2009

Detail Information

Publications332 found, 100 shown here

  1. pmc Combinatorial patterns of histone acetylations and methylations in the human genome
    Zhibin Wang
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 40:897-903. 2008
    ..Our data suggest that these histone modifications may act cooperatively to prepare chromatin for transcriptional activation...
  2. ncbi Lysine acetylation targets protein complexes and co-regulates major cellular functions
    Chunaram Choudhary
    Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried, Germany
    Science 325:834-40. 2009
    Lysine acetylation is a reversible posttranslational modification of proteins and plays a key role in regulating gene expression. Technological limitations have so far prevented a global analysis of lysine acetylation's cellular roles...
  3. ncbi Translating the histone code
    T Jenuwein
    Research Institute of Molecular Pathology IMP at the Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Science 293:1074-80. 2001
    ....
  4. pmc Regulation of cellular metabolism by protein lysine acetylation
    Shimin Zhao
    School of Life Sciences, Fudan University, Shanghai 20032, China
    Science 327:1000-4. 2010
    Protein lysine acetylation has emerged as a key posttranslational modification in cellular regulation, in particular through the modification of histones and nuclear transcription regulators...
  5. ncbi Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    Konrad T Howitz
    BIOMOL Research Laboratories, Inc, 5120 Butler Pike, Plymouth Meeting, Pennsylvania 19462, USA
    Nature 425:191-6. 2003
    ..We discuss possible evolutionary origins of this phenomenon and suggest new lines of research into the therapeutic use of sirtuin activators...
  6. ncbi Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    Anne Brunet
    Division of Neuroscience, Children s Hospital, and Department of Neurobiology, Center for Blood Research CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Science 303:2011-5. 2004
    ..Thus, one way in which members of the Sir2 family of proteins may increase organismal longevity is by tipping FOXO-dependent responses away from apoptosis and toward stress resistance...
  7. ncbi Resveratrol improves health and survival of mice on a high-calorie diet
    Joseph A Baur
    Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 444:337-42. 2006
    ..These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing...
  8. ncbi HDAC6 is a microtubule-associated deacetylase
    Charlotte Hubbert
    Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710, USA
    Nature 417:455-8. 2002
    Reversible acetylation of alpha-tubulin has been implicated in regulating microtubule stability and function. The distribution of acetylated alpha-tubulin is tightly controlled and stereotypic...
  9. pmc Histone deacetylases (HDACs): characterization of the classical HDAC family
    Annemieke J M de Ruijter
    Academic Medical Centre, University of Amsterdam, Amsterdam, The, Netherlands
    Biochem J 370:737-49. 2003
    ..modification of histones, the building blocks of chromatin, such as methylation, phosphorylation and acetylation. Acetylation is probably the best understood of these modifications: hyperacetylation leads to an increase in ..
  10. pmc AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
    Carles Canto
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Nature 458:1056-60. 2009
    ..The AMPK-induced SIRT1-mediated deacetylation of these targets explains many of the convergent biological effects of AMPK and SIRT1 on energy metabolism...
  11. pmc Lysine acetylation: codified crosstalk with other posttranslational modifications
    Xiang Jiao Yang
    Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, QC H3A1A1, Canada
    Mol Cell 31:449-61. 2008
    Lysine acetylation has emerged as a major posttranslational modification for histones...
  12. ncbi Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    S Imai
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 403:795-800. 2000
    ..These findings provide a molecular framework of NAD-dependent histone deacetylation that connects metabolism, genomic silencing and ageing in yeast and, perhaps, in higher eukaryotes...
  13. pmc Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
    Zhibin Wang
    Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 138:1019-31. 2009
    Histone acetyltransferases (HATs) and deacetylases (HDACs) function antagonistically to control histone acetylation. As acetylation is a histone mark for active transcription, HATs have been associated with active and HDACs with inactive ..
  14. ncbi Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
    Xiaolei Qiu
    Department of Nutritional Science and Toxicology, University of California, Berkeley, CA 94720, USA
    Cell Metab 12:662-7. 2010
    ..Our studies identify a defense program that CR provokes to reduce oxidative stress and suggest approaches to combat aging and oxidative stress-related diseases...
  15. pmc miR-34a repression of SIRT1 regulates apoptosis
    Munekazu Yamakuchi
    Departments of Medicine and Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:13421-6. 2008
    ..Finally, miR-34a itself is a transcriptional target of p53, suggesting a positive feedback loop between p53 and miR-34a. Thus, miR-34a functions as a tumor suppressor, in part, through a SIRT1-p53 pathway...
  16. ncbi Acetylation of non-histone proteins modulates cellular signalling at multiple levels
    Stephanie Spange
    Leibniz Institute for Age Research Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany
    Int J Biochem Cell Biol 41:185-98. 2009
    This review focuses on the posttranslational acetylation of non-histone proteins, which determines vital regulatory processes...
  17. ncbi Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    X Nan
    Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Nature 393:386-9. 1998
    ..The data suggest that two global mechanisms of gene regulation, DNA methylation and histone deacetylation, can be linked by MeCP2...
  18. ncbi Histone H4-K16 acetylation controls chromatin structure and protein interactions
    Michael Shogren-Knaak
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 311:844-7. 2006
    b>Acetylation of histone H4 on lysine 16 (H4-K16Ac) is a prevalent and reversible posttranslational chromatin modification in eukaryotes...
  19. pmc The many roles of histone deacetylases in development and physiology: implications for disease and therapy
    Michael Haberland
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
    Nat Rev Genet 10:32-42. 2009
    ..Mutant mice lacking individual HDACs are a powerful tool for defining the functions of HDACs in vivo and the molecular targets of HDAC inhibitors in disease...
  20. ncbi Substrate and functional diversity of lysine acetylation revealed by a proteomics survey
    Sung Chan Kim
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Cell 23:607-18. 2006
    b>Acetylation of proteins on lysine residues is a dynamic posttranslational modification that is known to play a key role in regulating transcription and other DNA-dependent nuclear processes...
  21. ncbi Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
    Mario F Fraga
    Cancer Epigenetics Laboratory, Molecular Pathology Program, Spanish National Cancer Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Nat Genet 37:391-400. 2005
    ..Our data suggest that the global loss of monoacetylation and trimethylation of histone H4 is a common hallmark of human tumor cells...
  22. ncbi The transcriptional coactivators p300 and CBP are histone acetyltransferases
    V V Ogryzko
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2753, USA
    Cell 87:953-9. 1996
    ..p300/CBP acetylates all four core histones in nucleosomes. These observations suggest that p300/CBP acetylates nucleosomes in concert with PCAF...
  23. ncbi Accessibility of the Drosophila genome discriminates PcG repression, H4K16 acetylation and replication timing
    Oliver Bell
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Nat Struct Mol Biol 17:894-900. 2010
    ..Together, these findings indicate that differential histone-modification patterns and the organization of replication have distinct and measurable effects on the exposure of the DNA template...
  24. pmc SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
    Matthew D Hirschey
    Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
    Nature 464:121-5. 2010
    ..Sirtuin 3 (SIRT3) is localized in the mitochondrial matrix, where it regulates the acetylation levels of metabolic enzymes, including acetyl coenzyme A synthetase 2 (refs 1, 2)...
  25. ncbi Suppression of inflammation by a synthetic histone mimic
    Edwige Nicodeme
    Centre de Recherche GSK, 27 Avenue du Québec, 91140 Villebon Sur Yvette, France
    Nature 468:1119-23. 2010
    ..Our findings suggest that synthetic compounds specifically targeting proteins that recognize post-translationally modified histones can serve as a new generation of immunomodulatory drugs...
  26. ncbi Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
    C J Phiel
    Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6148, USA
    J Biol Chem 276:36734-41. 2001
    ..Based on these observations, we propose that inhibition of histone deacetylase provides a mechanism for valproic acid-induced birth defects and could also explain the efficacy of valproic acid in the treatment of bipolar disorder...
  27. ncbi Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
    W Gu
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
    Cell 90:595-606. 1997
    ..Here, we demonstrate that p53 can be modified by acetylation both in vivo and in vitro...
  28. ncbi Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease
    Tiago Fleming Outeiro
    Alzheimer s Research Unit, MGH, Harvard Medical School, CNY 114, 16th Street, Charlestown, MA 02129, USA
    Science 317:516-9. 2007
    ..Furthermore, the inhibitors protected against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease. The results suggest a link between neurodegeneration and aging...
  29. ncbi HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention
    X J Yang
    Molecular Oncology Group, Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada
    Oncogene 26:5310-8. 2007
    b>Acetylation of the epsilon-amino group of a lysine residue was first discovered with histones in 1968, but the responsible enzymes, histone acetyltransferases and deacetylases, were not identified until the mid-1990s...
  30. ncbi Histone deacetylase inhibitors in cancer therapy
    Andrew A Lane
    Massachusetts General Hospital Cancer Center, Boston, MA 02214, USA
    J Clin Oncol 27:5459-68. 2009
    Epigenetic processes are implicated in cancer causation and progression. The acetylation status of histones regulates access of transcription factors to DNA and influences levels of gene expression...
  31. pmc Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux
    Qijun Wang
    State Key Laboratory of Genetic Engineering, Department of Microbiology, School of Life Sciences and Institute of Biomedical Sciences, Fudan University, Shanghai 200032, China
    Science 327:1004-7. 2010
    Lysine acetylation regulates many eukaryotic cellular processes, but its function in prokaryotes is largely unknown...
  32. pmc O-acetylation of Arabidopsis hemicellulose xyloglucan requires AXY4 or AXY4L, proteins with a TBL and DUF231 domain
    Sascha Gille
    Energy Biosciences Institute, University of California, Berkeley, California 94720, USA
    Plant Cell 23:4041-53. 2011
    ..mass profiling, two nonallelic mutants (axy4-1 and axy4-2) that have a 20 to 35% reduction in xyloglucan O-acetylation were identified...
  33. ncbi Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription
    Michael J Carrozza
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Cell 123:581-92. 2005
    ..Rco1 and Eaf3 were subunits specific to Rpd3S. Mutants of RCO1 and EAF3 exhibited increased acetylation in the FLO8 and STE11 open reading frames (ORFs) and the appearance of aberrant transcripts initiating within ..
  34. ncbi Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
    Yutaka Kondo
    Department of Leukemia, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Nat Genet 40:741-50. 2008
    ..These data establish EZH2-mediated H3K27triM as a mechanism of tumor-suppressor gene silencing in cancer that is potentially independent of promoter DNA methylation...
  35. pmc Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress
    Randa Tao
    Howard Hughes Medical Institute and Molecular Radiation Oncology, Radiation Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA
    Mol Cell 40:893-904. 2010
    ..deacetylation (lenti-MnSOD(K122-R)), increased MnSOD activity when expressed in MnSOD⁻/⁻ MEFs, suggesting acetylation directly regulates function...
  36. ncbi Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4
    Michiel Vermeulen
    Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, D 82152 Martinsried, Germany
    Cell 131:58-69. 2007
    ..Interestingly, asymmetric dimethylation of H3R2 selectively inhibits TFIID binding to H3K4me3, whereas acetylation of H3K9 and H3K14 potentiates TFIID interaction...
  37. pmc A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
    Bong Hyun Ahn
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:14447-52. 2008
    ..We further demonstrate that mitochondrial protein acetylation is markedly elevated in Sirt3(-/-) tissues...
  38. ncbi Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion
    Tom Rolef Ben-Shahar
    Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln sInn Fields, London WC2A 3PX, UK
    Science 321:563-6. 2008
    ..We identified spontaneous suppressors of the thermosensitive eco1-1 allele in budding yeast. An acetylation-mimicking mutation of a conserved lysine in cohesin's Smc3 subunit makes Eco1 dispensable for cell growth, and ..
  39. ncbi Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    Joseph T Rodgers
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 434:113-8. 2005
    ..Thus, we have identified a molecular mechanism whereby SIRT1 functions in glucose homeostasis as a modulator of PGC-1alpha. These findings have strong implications for the basic pathways of energy homeostasis, diabetes and lifespan...
  40. ncbi Acetylation and deacetylation of non-histone proteins
    Michele A Glozak
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, SRB 23011, Tampa, FL 33612, USA
    Gene 363:15-23. 2005
    ..by histone deacetylases (HDACs) opens yet another exciting new field of discovery in the role of the dynamic acetylation and deacetylation on cellular function...
  41. pmc Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation
    QiHuang Jin
    Nuclear Receptor Biology Section, CEB, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    EMBO J 30:249-62. 2011
    ..Here, we show deletion of GCN5/PCAF in cells specifically and dramatically reduces acetylation on histone H3K9 (H3K9ac) while deletion of CBP/p300 specifically and dramatically reduces acetylations on H3K18 ..
  42. ncbi Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth
    Lei Lv
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University, Shanghai 200032, China
    Mol Cell 42:719-30. 2011
    ..Here we show that PKM2 is acetylated on lysine 305 and that this acetylation is stimulated by high glucose concentration...
  43. pmc SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span
    Tiara L A Kawahara
    Program in Epithelial Biology, Division of Endocrinology, Gerontology, and Metabolism, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 136:62-74. 2009
    ..We propose that SIRT6 attenuates NF-kappaB signaling via H3K9 deacetylation at chromatin, and hyperactive NF-kappaB signaling may contribute to premature and normal aging...
  44. ncbi A molecular determinant for the establishment of sister chromatid cohesion
    Elcin Unal
    Howard Hughes Medical Institute and Department of Embryology, Carnegie Institution, 3520 San Martin Drive, Baltimore, MD 21218, USA
    Science 321:566-9. 2008
    ..Smc3p acetylation is induced in S phase after the chromatin loading of cohesin and is suppressed in G(1) and G(2)/M...
  45. pmc Acetylation of tau inhibits its degradation and contributes to tauopathy
    Sang Won Min
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Neuron 67:953-66. 2010
    ..We found that tau is acetylated and that tau acetylation prevents degradation of phosphorylated tau (p-tau)...
  46. pmc CBP/p300-mediated acetylation of histone H3 on lysine 56
    Chandrima Das
    Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, PO Box 6511, Aurora Colorado 80045, USA
    Nature 459:113-7. 2009
    b>Acetylation within the globular core domain of histone H3 on lysine 56 (H3K56) has recently been shown to have a critical role in packaging DNA into chromatin following DNA replication and repair in budding yeast...
  47. ncbi Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast
    Jinglan Zhang
    Center for Molecular Discovery, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell 31:143-51. 2008
    ..Our study thus identified a molecular target for the acetyltransferase Eco1 and revealed that Smc3 acetylation is a conserved mechanism in regulating sister chromatid cohesion.
  48. ncbi Altered histone acetylation is associated with age-dependent memory impairment in mice
    Shahaf Peleg
    Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Grisebach Str 5, D 37077 Goettingen, Germany
    Science 328:753-6. 2010
    ..During learning, aged mice display a specific deregulation of histone H4 lysine 12 (H4K12) acetylation and fail to initiate a hippocampal gene expression program associated with memory consolidation...
  49. pmc SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
    Dohoon Kim
    Howard Hughes Medical Institute, Picower Insitute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Boston, MA, USA
    EMBO J 26:3169-79. 2007
    ..resveratrol reduced neurodegeneration in the hippocampus, prevented learning impairment, and decreased the acetylation of the known SIRT1 substrates PGC-1alpha and p53...
  50. ncbi Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis
    Yi Tang
    Institute for Cancer Genetics, Surgeons, Columbia University, 1150 St Nicholas Ave, New York, New York 10032, USA
    Mol Cell 24:827-39. 2006
    ..we show that Tip60 is required for both cell growth arrest and apoptosis mediated by p53 and also induces its acetylation specifically at lysine 120 (K120) within the DNA-binding domain...
  51. pmc Loss-of-function mutation of REDUCED WALL ACETYLATION2 in Arabidopsis leads to reduced cell wall acetylation and increased resistance to Botrytis cinerea
    Yuzuki Manabe
    Joint BioEnergy Institute and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Plant Physiol 155:1068-78. 2011
    ..However, the enzymes involved in the polysaccharide acetylation have not been identified...
  52. ncbi Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5
    Christine Schlicker
    Laboratory of Biochemistry, Department of Physiological Chemistry, Ruhr University Bochum, Universitaetsstrasse 150, 44801 Bochum, Germany
    J Mol Biol 382:790-801. 2008
    ....
  53. pmc Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
    David B Lombard
    Howard Hughes Medical Institute, The Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 27:8807-14. 2007
    ..Overall, our results extend the recent finding of lysine acetylation of mitochondrial proteins and demonstrate that SIRT3 has evolved to control reversible lysine acetylation in ..
  54. pmc Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
    Jill C Milne
    Sirtris Pharmaceuticals Inc, 790 Memorial Drive, Cambridge, Massachusetts 02139, USA
    Nature 450:712-6. 2007
    ..Thus, SIRT1 activation is a promising new therapeutic approach for treating diseases of ageing such as type 2 diabetes...
  55. pmc CREBBP mutations in relapsed acute lymphoblastic leukaemia
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 471:235-9. 2011
    ..Functionally, the mutations impaired histone acetylation and transcriptional regulation of CREBBP targets, including glucocorticoid responsive genes...
  56. pmc Acetylation is indispensable for p53 activation
    Yi Tang
    Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell 133:612-26. 2008
    ..conflicting reports on the question of whether p53 posttranslational modifications, such as phosphorylation or acetylation, are essential or only play a subtle, fine-tuning role in the p53 response...
  57. pmc p53 post-translational modification: deregulated in tumorigenesis
    Chao Dai
    Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, 1130 St Nicholas Avenue, New York, NY 10032, USA
    Trends Mol Med 16:528-36. 2010
    ....
  58. ncbi Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map
    Sean R Collins
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158, USA
    Nature 446:806-10. 2007
    ..Rtt109 is the founding member of a novel class of histone acetyltransferases responsible for Asf1-dependent acetylation of histone H3 on lysine 56...
  59. ncbi Regulation of histone acetylation during memory formation in the hippocampus
    Jonathan M Levenson
    Baylor College of Medicine, Department of Neuroscience, Houston, Texas 77030, USA
    J Biol Chem 279:40545-59. 2004
    ..Specifically, we investigated hippocampal histone acetylation during the initial stages of consolidation of long term association memories in a contextual fear conditioning ..
  60. ncbi Histone acetylation in chromatin structure and transcription
    M Grunstein
    Department of Biological Chemistry, UCLA School of Medicine and the Molecular Biology Institute, University of California, Los Angeles 90095, USA
    Nature 389:349-52. 1997
    ..These acetylation patterns may direct histone assembly and help regulate the unfolding and activity of genes.
  61. ncbi HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
    Jeffrey J Kovacs
    Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710, USA
    Mol Cell 18:601-7. 2005
    ..Here, we present evidence that Hsp90 chaperone activity is regulated by reversible acetylation and controlled by the deacetylase HDAC6. We show that HDAC6 functions as an Hsp90 deacetylase...
  62. ncbi Recovery of learning and memory is associated with chromatin remodelling
    Andre Fischer
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 447:178-82. 2007
    ..Environmental enrichment correlated with chromatin modifications (increased histone-tail acetylation)...
  63. ncbi Duration of nuclear NF-kappaB action regulated by reversible acetylation
    - Chen Lf
    Gladstone Institute of Virology and Immunology, Department of Medicine, University of California, San Francisco, CA 94141, USA
    Science 293:1653-7. 2001
    ..Our studies now demonstrate that the RelA subunit of NF-kappaB is subject to inducible acetylation and that acetylated forms of RelA interact weakly, if at all, with IkappaBalpha...
  64. pmc ATP-citrate lyase links cellular metabolism to histone acetylation
    Kathryn E Wellen
    Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 324:1076-80. 2009
    Histone acetylation in single-cell eukaryotes relies on acetyl coenzyme A (acetyl-CoA) synthetase enzymes that use acetate to produce acetyl-CoA...
  65. ncbi Histone modifications in transcriptional regulation
    Shelley L Berger
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Genet Dev 12:142-8. 2002
    ..to consist of phosphorylation, methylation and ubiquitination, in addition to the better-characterized acetylation. This multiplicity of modifications, and their occurrence in patterns and dependent sequences, argues ..
  66. ncbi Building sister chromatid cohesion: smc3 acetylation counteracts an antiestablishment activity
    Benjamin D Rowland
    University of Oxford, Department of Biochemistry, South Parks Road, Oxford OX1 3QU, UK
    Mol Cell 33:763-74. 2009
    ..According to this model, Eco1 promotes sister DNA entrapment partly by relieving an antiestablishment activity associated with Scc3, Pds5, and Rad61...
  67. pmc Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation
    Chuanbing Bian
    School of Life Sciences, University of Science and Technology of China, Anhui, People s Republic of China
    EMBO J 30:2829-42. 2011
    ..Our in vitro and in vivo functional assays show that Sgf29 recognizes methylated H3K4 to recruit the SAGA complex to its targets sites and mediates histone H3 acetylation, underscoring the importance of Sgf29 in gene regulation.
  68. pmc Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation
    Stephen J Haggarty
    Department of Molecular and Cellular Biology, and Harvard Institute of Chemistry and Cell Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 100:4389-94. 2003
    Protein acetylation, especially histone acetylation, is the subject of both research and clinical investigation. At least four small-molecule histone deacetylase inhibitors are currently in clinical trials for the treatment of cancer...
  69. pmc N-terminal acetylation of cellular proteins creates specific degradation signals
    Cheol Sang Hwang
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 327:973-7. 2010
    ..Removal of N-terminal Met by Met-aminopeptidases frequently leads to Nt-acetylation of the resulting N-terminal alanine (Ala), valine (Val), serine (Ser), threonine (Thr), and cysteine (Cys) ..
  70. pmc Histone H4 lysine 16 acetylation regulates cellular lifespan
    Weiwei Dang
    Gene Expression and Regulation Program, The Wistar Institute Philadelphia, Pennsylvania 19104, USA
    Nature 459:802-7. 2009
    ..of the family to be found, establishes and maintains chromatin silencing by removing histone H4 lysine 16 acetylation and bringing in other silencing proteins...
  71. ncbi Covalent modifications of histones during development and disease pathogenesis
    Sukesh R Bhaumik
    Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA
    Nat Struct Mol Biol 14:1008-16. 2007
    ..and genetic properties of the enzymatic machinery involved in four different types of histone modification: acetylation, ubiquitination, phosphorylation and methylation...
  72. pmc Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
    William C Hallows
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 103:10230-5. 2006
    ..We demonstrate that mammalian Acetyl-CoA synthetases (AceCSs) are regulated by reversible acetylation and that sirtuins activate AceCSs by deacetylation...
  73. pmc Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2
    Bjoern Schwer
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 103:10224-9. 2006
    ..that a mammalian sirtuin directly controls the activity of a metabolic enzyme by means of reversible lysine acetylation. Because the activity of a bacterial ortholog of AceCS2, called ACS, is controlled via deacetylation by a ..
  74. pmc TRIM24 links a non-canonical histone signature to breast cancer
    Wen Wei Tsai
    Department of Biochemistry and Molecular Biology, Program in Genes and Development, Graduate School of Biomedical Sciences, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nature 468:927-32. 2010
    ..The PHD-Bromo of TRIM24 provides a structural rationale for chromatin activation through a non-canonical histone signature, establishing a new route by which chromatin readers may influence cancer pathogenesis...
  75. pmc HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo
    Yu Zhang
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    EMBO J 22:1168-79. 2003
    ..Reversible acetylation on the epsilon-amino group of alpha-tubulin Lys40 marks stabilized microtubule structures and may contribute to ..
  76. ncbi HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation
    P Gaub
    Center for Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Germany
    Cell Death Differ 17:1392-408. 2010
    Neuronal outgrowth is guided by both extrinsic and intrinsic factors, involving transcriptional regulation. The acetylation of histones and transcription factors, which facilitates promoter accessibility, ultimately promotes ..
  77. ncbi Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons
    Koichi Hasegawa
    Laboratory of Regulation of Neuronal Development, Institute for Protein Research, Osaka University, Osaka 565 0871, Japan
    J Neurosci 28:8772-84. 2008
    ..Here we report that necdin regulates the acetylation status of p53 via Sirt1 to suppress p53-dependent apoptosis in postmitotic neurons...
  78. ncbi Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65
    Rosemary Kiernan
    Laboratoire de Virologie Moleculaire, Institut de Genetique Humaine, Montpellier 34296, France
    J Biol Chem 278:2758-66. 2003
    ..Both HDAC2 and HDAC3 interact with p65, although only HDAC3 was able to deacetylate p65. Acetylation of p65 reduces its ability to bind kappaBeta-DNA...
  79. ncbi Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
    J S Steffan
    Department of Psychiatry and Human Behavior, Gillespie 2121, University of California, Irvine, California 92697, USA
    Nature 413:739-43. 2001
    ..These findings raise the possibility that therapy with HDAC inhibitors may slow or prevent the progressive neurodegeneration seen in Huntington's disease and other polyglutamine-repeat diseases, even after the onset of symptoms...
  80. pmc Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally
    Yu Zhang
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, P O Box 2543, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Mol Cell Biol 28:1688-701. 2008
    ..To investigate the in vivo functions of HDAC6 and the relevance of tubulin acetylation/deacetylation, we targeted the HDAC6 gene by homologous recombination in embryonic stem cells and generated ..
  81. pmc Acetylation of the p53 DNA-binding domain regulates apoptosis induction
    Stephen M Sykes
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Mol Cell 24:841-51. 2006
    ..This modification, acetylation of lysine 120 (K120), occurs rapidly after DNA damage and is catalyzed by the MYST family acetyltransferases ..
  82. pmc An acetylation site in the middle domain of Hsp90 regulates chaperone function
    Bradley T Scroggins
    Urologic Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Mol Cell 25:151-9. 2007
    ..Hsp90 is subject to an array of posttranslational modifications that affect its function, including acetylation. Histone deacetylase (HDAC) inhibitors and knockdown of HDAC6 induce Hsp90 acetylation and inhibit its activity...
  83. pmc The genomic landscape of histone modifications in human T cells
    Tae Young Roh
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:15782-7. 2006
    ..Our data reveal that rapidly inducible genes are associated with the H3 acetylation and H3K4me3 modifications, suggesting they assume a chromatin structure poised for activation...
  84. ncbi C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB
    Sonja I Gringhuis
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Immunity 26:605-16. 2007
    ..trigger DC-SIGN on human DCs to activate the serine and threonine kinase Raf-1, which subsequently leads to acetylation of the NF-kappaB subunit p65, but only after TLR-induced activation of NF-kappaB...
  85. pmc SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70
    Nagalingam R Sundaresan
    University of Chicago Medical Center, Committee on Cellular and Molecular Physiology, Biological Science Division, University of Chicago, Chicago, Illinois 60637, USA
    Mol Cell Biol 28:6384-401. 2008
    ..These studies underscore an essential role of SIRT3 in the survival of cardiomyocytes in stress situations...
  86. ncbi Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex
    P A Grant
    Department of Biochemistry and Molecular Biology and The Center for Gene Regulation, The Pennsylvania State University, University Park 16802 4500, USA
    Genes Dev 11:1640-50. 1997
    ..it fails to acetylate histones contained in nucleosomes, indicating that additional components are required for acetylation of chromosomal histones...
  87. pmc SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production
    Tadahiro Shimazu
    Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
    Cell Metab 12:654-61. 2010
    ..Our findings show SIRT3 regulates ketone body production during fasting and provide molecular insight into how protein acetylation can regulate enzymatic activity.
  88. ncbi FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction
    Yukari Ido Kitamura
    Naomi Berrie Diabetes Center, Department of Medicine, Columbia University, New York, New York 10032, USA
    Cell Metab 2:153-63. 2005
    ..Using acetylation-defective and acetylation-mimicking mutants, we demonstrate that acetylation targets FoxO1 to Pml and prevents ..
  89. ncbi HDAC6 a new cellular stress surveillance factor
    Patrick Matthias
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
    Cell Cycle 7:7-10. 2008
    ..HDAC6 appears both as a sensor of stressful stimuli and as an effector, which, thanks to its wide range of activities, mediates and coordinates appropriate cell responses...
  90. pmc Acetylation by the transcriptional coactivator Gcn5 plays a novel role in co-transcriptional spliceosome assembly
    Felizza Q Gunderson
    Department of Biology, Molecular Biology Section, University of California San Diego, La Jolla, California, USA
    PLoS Genet 5:e1000682. 2009
    ..of defective transcription elongation for these genes in the absence of Gcn5, while Gcn5-dependent histone acetylation is enriched in the promoter regions...
  91. pmc MEC-17 is an alpha-tubulin acetyltransferase
    Jyothi S Akella
    Department of Cellular Biology, University of Georgia, Athens, Georgia 30602, USA
    Nature 467:218-22. 2010
    ..b>Acetylation of the epsilon-amino group of K40 on alpha-tubulin is a conserved PTM on the luminal side of microtubules that ..
  92. pmc Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes
    Diego Pasini
    Biotech Research and Innovation Centre BRIC, University of Copenhagen, Copenhagen, Denmark
    Nucleic Acids Res 38:4958-69. 2010
    ..We show that loss of PRC2 activity results in a global increase in H3K27 acetylation. The methylation to acetylation switch correlates with the transcriptional activation of PcG target genes, both ..
  93. pmc Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease
    Emma Hockly
    Medical and Molecular Genetics, Guy s, King s and St Thomas School of Medicine, King s College London, Eighth Floor Guy s Tower, Guy s Hospital, London SE1 9RT, United Kingdom
    Proc Natl Acad Sci U S A 100:2041-6. 2003
    ..We show that SAHA crosses the blood-brain barrier and increases histone acetylation in the brain...
  94. pmc Multiple roles of HDAC inhibition in neurodegenerative conditions
    De Maw Chuang
    Molecular Neurobiology Section, National Institute of Mental Health, National Institutes of Health, 10 Center Drive MSC 1363, Bethesda, MD 20892 1363, USA
    Trends Neurosci 32:591-601. 2009
    Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in histones and other proteins and in regulating fundamental cellular activities such as transcription...
  95. pmc The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
    Yasukazu Nakahata
    Department of Pharmacology, University of California, Irvine, CA 92697, USA
    Cell 134:329-40. 2008
    ..The central clock protein CLOCK has HAT properties. It directs acetylation of histone H3 and of its dimerization partner BMAL1 at Lys537, an event essential for circadian function...
  96. ncbi SIRT1 regulates circadian clock gene expression through PER2 deacetylation
    Gad Asher
    Department of Molecular Biology, Sciences III, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
    Cell 134:317-28. 2008
    ..Given the NAD(+) dependence of SIRT1 deacetylase activity, it is likely that SIRT1 connects cellular metabolism to the circadian core clockwork circuitry...
  97. ncbi Biomarkers for predicting clinical responses to HDAC inhibitors
    Lindsay Stimson
    Dept of Clinical Pharmacology, Laboratory of Cancer Biology, Oxford, United Kingdom
    Cancer Lett 280:177-83. 2009
    Post-translational modifications of histone and non-histone proteins by acetylation are known to play a key role in tumourigenesis...
  98. pmc HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer
    Junkui Ai
    Department of Urology, University of Pittsburgh School of Medicine, Pennsylvania 15232, USA
    Mol Endocrinol 23:1963-72. 2009
    ..deacetylase 6 (HDAC6) is implicated, but has not been proven, in regulating AR activity via modulating Hsp90 acetylation. Here, we report that knockdown of HDAC6 in C4-2 cells using short hairpin RNA impaired ligand-independent ..
  99. pmc Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis
    Yu yi Lin
    High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 136:1073-84. 2009
    ..Among these, acetylation sites (Lys19 and 514) of phosphoenolpyruvate carboxykinase (Pck1p) were determined by tandem mass spectrometry...
  100. ncbi Genome-wide replication-independent histone H3 exchange occurs predominantly at promoters and implicates H3 K56 acetylation and Asf1
    Anne Rufiange
    Centre de recherche en cancérologie de l Université Laval, L Hôtel Dieu de Québec CHUQ, Quebec, Canada
    Mol Cell 27:393-405. 2007
    ..This could facilitate induction of repressed genes. Importantly, we show that histone H3 K56 acetylation, a replication-associated mark, is also present in replication-independent newly assembled nucleosomes and ..
  101. pmc Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assembly
    Qing Li
    Department of Biochemistry and Molecular Biology, Mayo Clinic, College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Cell 134:244-55. 2008
    ..However, the molecular functions of the acetylation of newly synthesized histones in this DNA replication-coupled nucleosome assembly pathway remain enigmatic...

Research Grants16

  1. Histone Deacetylases and reversible acetylation in signaling and disease
    JOHN DENU; Fiscal Year: 2009
    ..Over the last several years, emerging evidence suggests that acetylation of protein lysine residues may rival reversible phosphorylation as a major regulatory mechanism of cellular ..
  2. Histone Methylation: a role in excessive ethanol intake and self-administration
    Jennifer A Rinker; Fiscal Year: 2012
    ..These posttranslational changes include: acetylation, phosphorylation, and methylation of histone amino acid residues...
  3. Role of Phospholipase C in Transcriptional Regulation
    Ales Vancura; Fiscal Year: 2009
    ..data indicate that plc1 cells display several phenotypes consistent with the role of Plc1p and InsPs in histone acetylation: (i) defect in recruitment of the SAGA complex to Sko1p-regulated promoters (Guha et al...
  4. Genistein and Prostate Cancer
    Rajvir Dahiya; Fiscal Year: 2010
    ..inhibits prostate cancer growth through modulation of epigenetic events, such as DNA methylation and histone acetylation. To test this hypothesis, we will analyze: 1) Global methylation and enzymatic activity of DNA ..
  5. HTS development for targeted anti-fungal small molecules
    Paul D Kaufman; Fiscal Year: 2010
    ..In fungi, H3-K56 acetylation occurs on all newly synthesized molecules, but H3-K56ac is either not abundant or even detectable in mammalian ..
  6. Modulation of c-MYC Functions in an HTLV-1 Model for Carcinogenesis
    Robert Harrod; Fiscal Year: 2009
    ..HTLV-1 p30II induces Lys- acetylation of c-MYC...
  7. Structure and Mechanism of Pathogen SET Domain HKMTs
    Ming Ming Zhou; Fiscal Year: 2009
    Site-specific post-translational modifications of histones that include methylation, acetylation, phosphorylation and ubiquitination function individually and/or combinatorially as fundamental epigenetic mechanisms in histone-directed ..
  8. Role of the Fetus in the Initiation of Parturition
    CAROLE MENDELSON; Fiscal Year: 2004
    ..CREB-binding protein (CBP) and members of the steroid receptor coactivator (SRC) family, and in histone acetylation in myometrium of women in labor and in uterine tissues of pregnant mice at term...
  9. METABOLIC BASIS OF SULFONAMIDE TOXICITY IN AIDS PATIENTS
    CRAIG SVENSSON; Fiscal Year: 1999
    ..The specific aims are to determine: 1. IF ARYLAMINE N-ACETYLATION ACTIVITY IS REDUCED IN HIV INFECTED PATIENTS...
  10. Hypoxia Signaling, Chromatin Remodeling and Nickel Carcinogenesis
    Max Costa; Fiscal Year: 2009
    ..Hypoxia or agents that mimic hypoxia cause a global loss of histone acetylation and increase the methylation of H3 lysine 9 which is the chromatin mark of gene silencing for the individual ..
  11. WHY IS HISTONE ACETYLATION REDUCED AT MITOSIS?
    James Paulson; Fiscal Year: 1992
    ..from the applicant's abstract): Histones, the major proteins of eukaryotic chromosomes, undergo reversible acetylation at certain lysine residues, but this acetylation is drastically reduced during normal mitosis and in metaphase-..
  12. Cell Growth Inhibiton and Estrogen Action
    Barry Markaverich; Fiscal Year: 2004
    ..Histone acetylation is temporally and functionally coupled to DNA replication and gene expression in experimental systems including ..
  13. ASPIRIN'S FIBRINOLYTIC EFFECT--ACETYLATION OF FIBRINOGEN
    Thorir Bjornsson; Fiscal Year: 1992
    ..antithrombotic mechanism involves an irreversible inactivation of the platelet enzyme cyclooxygenase through o- acetylation of active site serine...
  14. 9-0 ACETYLATED SIALIC ACIDS ON T CELLS
    Laura Martin; Fiscal Year: 2002
    ..9-O-acetylation can affect biologic properties of underlying molecules, altering host-pathogen recognition, modulating ..
  15. Regulation of Hepatic Gluconeogenesis by the CREB:TORC2 Pathway
    Marc R Montminy; Fiscal Year: 2010
    ..Preliminary studies indicate that TORC2 is transiently activated through P300-dependent acetylation during early fasting, when it stimulates the gluconeogenic program via an association with a histone methyl-..
  16. Resistance of Bacillus anthracis to lysozyme
    Jonathan Dworkin; Fiscal Year: 2009
    ..In Staphylococcus aureus, O-acetylation of the cell wall peptidoglycan has been identified as the modification that is responsible for lysozyme ..