clinical chemistry

Summary

Summary: The specialty of analytical chemistry applied to assays of physiologically important substances found in blood, urine, tissues, and other biological fluids for the purpose of aiding the physician in making a diagnosis or following therapy.

Top Publications

  1. ncbi Biological reference intervals and ISO 15189
    Xavier Fuentes-Arderiu
    Clin Chim Acta 364:365-6. 2006
  2. ncbi Automated urinalysis: first experiences and a comparison between the Iris iQ200 urine microscopy system, the Sysmex UF-100 flow cytometer and manual microscopic particle counting
    Noushin Shayanfar
    Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
    Clin Chem Lab Med 45:1251-6. 2007
  3. ncbi Quality performance of newborn screening systems: strategies for improvement
    D Webster
    NZ National Testing Centre, PO Box 872, Auckland, New Zealand
    J Inherit Metab Dis 30:576-84. 2007
  4. ncbi Components of quality control
    A A Hurley
    Comprehensive Cytometric Consulting, Ballwin, Missouri, USA
    Curr Protoc Cytom . 2001
  5. ncbi Impact of blood collection devices on clinical chemistry assays
    Raffick A R Bowen
    Department of Pathology, Stanford University, 300 Pasteur Drive, Room H1507 B, Stanford, CA 94305, USA
    Clin Biochem 43:4-25. 2010
  6. ncbi ROC curves in clinical chemistry: uses, misuses, and possible solutions
    Nancy A Obuchowski
    Department of Biostatistics, Division of Radiology Wb4, The Cleveland Clinic Foundation, Cleveland, OH 44195 5196, USA
    Clin Chem 50:1118-25. 2004
  7. ncbi Advanced glycoxidation end products in chronic diseases-clinical chemistry and genetic background
    Marta Kalousova
    Institute of Clinical Chemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Katerinska 32, 12108 Prague 2, Czech Republic
    Mutat Res 579:37-46. 2005
  8. ncbi Laboratory reference values for healthy adults from southern Tanzania
    Elmar Saathoff
    Abteilung fuer Infektions und Tropenmedizin, Klinikum der Universitaet Muenchen, Munich, Germany
    Trop Med Int Health 13:612-25. 2008
  9. ncbi State of the art in trueness and interlaboratory harmonization for 10 analytes in general clinical chemistry
    W Greg Miller
    Department of Pathology, Virginia Commonwealth University, PO Box 980286, Richmond, VA 23298 0286, USA
    Arch Pathol Lab Med 132:838-46. 2008
  10. ncbi The European Register of Specialists in Clinical Chemistry and Laboratory Medicine: guide to the Register, version 3-2010
    Janet McMurray
    Association for Clinical Biochemistry, London, UK
    Clin Chem Lab Med 48:999-1008. 2010

Research Grants

  1. IGFBP5 AND INTEGRINS AND CONTROLLING IGF1 ACTIONS
    David Clemmons; Fiscal Year: 2002
  2. NOVEL CONTRACEPTIVES WITH ANTI-HIV ACTIVITY
    OSMOND D CRUZ; Fiscal Year: 2001
  3. PHI-443: Novel Non-Spermicidal Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
  4. Phase II SBIR: WHI-07: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
  5. Stampidine: A Novel Broad-Spectrum Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
  6. PHI 346: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
  7. FLP-102: Rationally Engineered Antiviral Protein
    OSMOND D CRUZ; Fiscal Year: 2003
  8. Vanadocenes as a New Class of Spermicidal Drugs
    OSMOND D CRUZ; Fiscal Year: 2007
  9. METVAN: A Novel Anticancer Agent
    OSMOND D CRUZ; Fiscal Year: 2003
  10. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2008

Detail Information

Publications196 found, 100 shown here

  1. ncbi Biological reference intervals and ISO 15189
    Xavier Fuentes-Arderiu
    Clin Chim Acta 364:365-6. 2006
  2. ncbi Automated urinalysis: first experiences and a comparison between the Iris iQ200 urine microscopy system, the Sysmex UF-100 flow cytometer and manual microscopic particle counting
    Noushin Shayanfar
    Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
    Clin Chem Lab Med 45:1251-6. 2007
    ..We compared the diagnostic performance of two automated urine sediment analyzers and combined dipstick/automated urine analysis with that of the traditional dipstick/microscopy algorithm...
  3. ncbi Quality performance of newborn screening systems: strategies for improvement
    D Webster
    NZ National Testing Centre, PO Box 872, Auckland, New Zealand
    J Inherit Metab Dis 30:576-84. 2007
    ..Outside the laboratory, standards, education and protocols improve the quality of specimen collection, diagnosis and treatment, which together produce the health gains...
  4. ncbi Components of quality control
    A A Hurley
    Comprehensive Cytometric Consulting, Ballwin, Missouri, USA
    Curr Protoc Cytom . 2001
    ..This unit presents information on the techniques for determining when results are in control or out of control...
  5. ncbi Impact of blood collection devices on clinical chemistry assays
    Raffick A R Bowen
    Department of Pathology, Stanford University, 300 Pasteur Drive, Room H1507 B, Stanford, CA 94305, USA
    Clin Biochem 43:4-25. 2010
    ..This review will identify sources of exogenous substances in blood specimens and propose methods to minimize their impact on clinical chemistry assays.
  6. ncbi ROC curves in clinical chemistry: uses, misuses, and possible solutions
    Nancy A Obuchowski
    Department of Biostatistics, Division of Radiology Wb4, The Cleveland Clinic Foundation, Cleveland, OH 44195 5196, USA
    Clin Chem 50:1118-25. 2004
    ..Our aims were to observe how the accuracy of clinical laboratory diagnostic tests is assessed, compared, and reported in the literature; to identify common problems with the use of ROC curves; and to offer some possible solutions...
  7. ncbi Advanced glycoxidation end products in chronic diseases-clinical chemistry and genetic background
    Marta Kalousova
    Institute of Clinical Chemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Katerinska 32, 12108 Prague 2, Czech Republic
    Mutat Res 579:37-46. 2005
    ....
  8. ncbi Laboratory reference values for healthy adults from southern Tanzania
    Elmar Saathoff
    Abteilung fuer Infektions und Tropenmedizin, Klinikum der Universitaet Muenchen, Munich, Germany
    Trop Med Int Health 13:612-25. 2008
    ..To define and discuss reference ranges for commonly determined laboratory parameters in healthy adults from southern Tanzania...
  9. ncbi State of the art in trueness and interlaboratory harmonization for 10 analytes in general clinical chemistry
    W Greg Miller
    Department of Pathology, Virginia Commonwealth University, PO Box 980286, Richmond, VA 23298 0286, USA
    Arch Pathol Lab Med 132:838-46. 2008
    ..Harmonization and standardization of results among different clinical laboratories is necessary for clinical practice guidelines to be established...
  10. ncbi The European Register of Specialists in Clinical Chemistry and Laboratory Medicine: guide to the Register, version 3-2010
    Janet McMurray
    Association for Clinical Biochemistry, London, UK
    Clin Chem Lab Med 48:999-1008. 2010
    In 1997, the European Communities Confederation of Clinical Chemistry and Laboratory Medicine (EC4) set up a Register for European Specialists in Clinical Chemistry and Laboratory Medicine...
  11. ncbi Cell-based biosensors in clinical chemistry
    Spiridon E Kintzios
    EMBIO Laboratory of Plant Physiology, Faculty of Biotechnology, Agricultural University of Athens, Iera Odos 75, 11855 Athens, Greece
    Mini Rev Med Chem 7:1019-26. 2007
    ..The present review focuses on the most successful technologies used for the detection of ultra-low concentrations of bioactive analytes (such as metabolic markers and pathogens) in clinical samples...
  12. ncbi Drug interference in clinical chemistry: recommendation of drugs and their concentrations to be used in drug interference studies
    O Sonntag
    Scientific Department, Ortho Clinical Diagnostics, Eichenau, Germany
    Ann Clin Biochem 38:376-85. 2001
    ..The study confirmed the usefulness of the recommendation...
  13. ncbi The European Register for Specialists in Clinical Chemistry and Laboratory Medicine: guide to the Register Version 2-2003 and procedure for re-registration
    Eberhard Gurr
    Abteilung für klinische Chemie, Zentralkrankenhaus Links der Weser, Bremen, Germany
    Clin Chem Lab Med 41:238-47. 2003
    The European Communities Confederation of Clinical Chemistry and Laboratory Medicine (EC4) opened a Register for European Chemists in 1997. The operation of the Register is undertaken by a Register Committee (EC4RC)...
  14. ncbi Methodology in diagnostic laboratory test research in clinical chemistry and clinical chemistry and laboratory medicine
    Blanca Lumbreras-Lacarra
    Department of Clinic Analysis, General University Hospital of Alicante, Alicante, Spain
    Clin Chem 50:530-6. 2004
    ..Knowledge of the main flaws affecting diagnostic laboratory test research is the first step for improving its quality. We assessed the methodologic aspects of articles on laboratory tests...
  15. ncbi Reference values for clinical chemistry and clinical hematology parameters in cynomolgus monkeys
    Henk Jan Schuurman
    Imutran Ltd A Novartis Pharma AG Company, Cambridge, UK
    Xenotransplantation 12:72-5. 2005
    In vivo xenotransplantation modeling in large animal species is often performed in nonhuman primates, including baboons. For proper data interpretation, reference values for clinical chemistry and hematology are required.
  16. ncbi Quality of interpretative commenting on common clinical chemistry results in the Asia-Pacific region and Africa
    Samuel D Vasikaran
    Department of Core Clinical Pathology and Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, WA, Australia
    Clin Chem Lab Med 47:963-70. 2009
    ..Interpretative commenting is an important activity of the clinical diagnostic laboratory. We describe a study of interpretative commenting abilities among senior laboratory professionals in the Asia-Pacific region and Africa...
  17. ncbi Accreditation of medical laboratories in Croatia--experiences of the Institute of Clinical Chemistry, University Hospital "Merkur", Zagreb
    Zlata Flegar-Meštrić
    Institute of Clinical Chemistry, University Hospital Merkur, Zagreb, Croatia
    Coll Antropol 34:181-6. 2010
    ....
  18. ncbi Reference values of clinical chemistry and hematology parameters in rhesus monkeys (Macaca mulatta)
    Younan Chen
    West China Hospital, Sichuan University, Chengdu, China
    Xenotransplantation 16:496-501. 2009
    Rhesus monkey models are valuable to the studies of human biology. Reference values for clinical chemistry and hematology parameters of rhesus monkeys are required for proper data interpretation.
  19. ncbi Hepcidin: from discovery to differential diagnosis
    Erwin H J M Kemna
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, P O Box 9101 6500 HB Nijmegen, The Netherlands
    Haematologica 93:90-7. 2008
    ..Ongoing studies in humans should provide us with more information on the etiology of iron metabolism disorders in order to create new therapeutic strategies and improve differential diagnosis protocols for these diseases...
  20. ncbi Evaluation of the Dade Behring Dimension RxL clinical chemistry analyzer
    S Cuka
    Clinical Hospital Center Rijeka, Department for Laboratory Diagnostics, Croatia
    Clin Lab 47:35-40. 2001
    The performance of the Dade Behring Dimension RxL clinical chemistry analyzer was evaluated according to the guidelines of the European Committee for Clinical Laboratory Standards...
  21. ncbi Immunosensors--principles and applications to clinical chemistry
    P B Luppa
    Institute for Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str 22, D 81675 Munich, Germany
    Clin Chim Acta 314:1-26. 2001
    ..The main developments are electrochemical, optical, and microgravimetric immunosensors. In contrast to immunoassay, modern transducer technology enables the label-free detection and quantification of the immune complex...
  22. ncbi Biosensors in clinical chemistry
    Paul D'Orazio
    Instrumentation Laboratory, 101 Hartwell Avenue, Lexington MA 02421, USA
    Clin Chim Acta 334:41-69. 2003
    ..Present-day applications of biosensors to clinical chemistry are reviewed, including basic and applied research, commercial applications and fabrication techniques...
  23. ncbi Population-based genomewide genetic analysis of common clinical chemistry analytes
    Daniel I Chasman
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Clin Chem 55:39-51. 2009
    ..These early studies have also led to development of a set of principles for conducting a successful genomewide association study (GWAS)...
  24. ncbi Effect of analytical run length on quality-control (QC) performance and the QC planning process
    C A Parvin
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Chem 43:2149-54. 1997
    ....
  25. ncbi Evaluation of the Olympus AU 400 clinical chemistry analyzer
    A Bilic
    Clinical Hospital Centre Zagreb, Clinical Institute of Laboratory Diagnosis, Zagreb University School of Medicine, Croatia
    Clin Lab 46:1-6. 2000
    The performance of the Olympus AU 400 clinical chemistry analyzer was evaluated according to the guidelines of the European Committee for Clinical Laboratory Standards...
  26. ncbi Mass spectrometry-based proteomics: current status and potential use in clinical chemistry
    Pierre Alain Binz
    Proteome Informatics Group, Swiss Institute of Bioinformatics, Geneva, Switzerland
    Clin Chem Lab Med 41:1540-51. 2003
    ..We also describe the major experimental workflows that are typically used in proteomics today, with a focus on those incorporating MS as a major analysis tool...
  27. ncbi Reference intervals for eight enzymes in blood of adult females and males measured in accordance with the International Federation of Clinical Chemistry reference system at 37 degrees C: part of the Nordic Reference Interval Project
    J H Strømme
    Department of Clinical Chemistry, Ullevaal University Hospital, NO 0407 Oslo, Norway
    Scand J Clin Lab Invest 64:371-84. 2004
    ..Only results obtained with the International Federation of Clinical Chemistry (IFCC) compatible measuring systems were selected for estimation of the enzyme reference intervals...
  28. ncbi The Nordic Trueness Project 2002: use of reference measurement procedure values in a general clinical chemistry survey
    M M Pedersen
    DEKS, 54M1 Herlev University Hospital, DK 2730 Herlev, Denmark
    Scand J Clin Lab Invest 64:309-20. 2004
    ..The findings should be used to discuss to what extent reference measurement procedure values are useful and cost-efficient for this type of material...
  29. ncbi A selected history and future of immunoassay development and applications in clinical chemistry
    Alan H B Wu
    Department of Laboratory Medicine, University of California, San Francisco, Clinical Chemistry Laboratory, San Francisco General Hospital, San Francisco, CA 94110, USA
    Clin Chim Acta 369:119-24. 2006
    ..The first immunoassay was described by Berson and Yalow in 1959. Their work resulted in their receipt of the Nobel Prize in Medicine in 1977. Since this introduction, immunoassays have evolved considerably...
  30. ncbi Stability of analytes related to clinical chemistry and bone metabolism in blood specimens after delayed processing
    Sara R Zwart
    Universities Space Research Association, Houston, TX, USA
    Clin Biochem 42:907-10. 2009
    We investigated the stability of 36 analytes related to clinical chemistry in a controlled storage study.
  31. ncbi Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in clinical chemistry
    Laure F Marvin
    Nestle Research Center, Nestec Ltd, Vers chez les Blanc, PO Box 44, 1000 Lausanne 26, Switzerland
    Clin Chim Acta 337:11-21. 2003
    ..In this paper, we will review the application of MALDI-Tof-MS in clinical chemistry and biology. MALDI-Tof-MS is used in clinical chemistry, e.g...
  32. ncbi Nephrolithiasis at the turn of the 18th to 19th centuries: biochemical disturbances. A genuine cascade giving rise to clinical chemistry
    Gabriel Richet
    Académie nationale de médecine, 76 rue d Assas, F 75006 Paris, France
    Am J Nephrol 22:254-9. 2002
    ..quot;We would probably still not have chemistry, botany, or anatomy had not physicians studied and taught them." G. Cuvier Report on Natural Sciences, Paris 1980...
  33. ncbi Protein profiling as a diagnostic tool in clinical chemistry: a review
    Judith A P Bons
    Department of Clinical Chemistry, University Hospital Maastricht, Maastricht, The Netherlands
    Clin Chem Lab Med 43:1281-90. 2005
    ..Further progress in protein profiling as a diagnostic tool requires a more comprehensive description of technical details in all future studies...
  34. ncbi Influence of hemolysis on routine clinical chemistry testing
    Giuseppe Lippi
    Istituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Verona, Italy
    Clin Chem Lab Med 44:311-6. 2006
    Preanalytical factors are the main source of variation in clinical chemistry testing and among the major determinants of preanalytical variability, sample hemolysis can exert a strong influence on result reliability...
  35. ncbi Cardiac troponin assays: a view from the clinical chemistry laboratory
    Stacy E F Melanson
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 116:e501-4. 2007
  36. ncbi Medical chemists and the origins of clinical chemistry in Britain (circa 1750-1850)
    Noel G Coley
    Clin Chem 50:961-72. 2004
    In this history, I review developments leading toward the establishment of clinical chemistry in Britain...
  37. ncbi Fundamentals of quality assessment of molecular amplification methods in clinical diagnostics. International Federation of Clinical Chemistry Scientific Division Committee on Molecular Biology Techniques
    M Neumaier
    Abteilung für klinische Chemie, Medizinische Klinik, Universitats Krankenhaus Eppendorf, Hamburg, Germany
    Clin Chem 44:12-26. 1998
    ..Accordingly, this publication is intended to serve as a recommendation for good laboratory practice and internal quality control and as a guide to troubleshooting, primarily in amplification techniques...
  38. ncbi Description of a generally applicable model for the evaluation of uncertainty of measurement in clinical chemistry
    J Kristiansen
    The National Institute of Occupational Health, Copenhagen, Denmark
    Clin Chem Lab Med 39:920-31. 2001
    There is a growing pressure on clinical chemistry laboratories to conform to quality standards that require the evaluation and expression of the uncertainty of results of measurement...
  39. ncbi Proteome analysis in the clinical chemistry laboratory: myth or reality?
    Pier Giorgio Righetti
    Department of Agricultural and Industrial Biotechnologies, University of Verona, Strada Le Grazie No 15, Verona 37134, Italy
    Clin Chim Acta 357:123-39. 2005
    ....
  40. ncbi Performance characteristics of several rules for self-interpretation of proficiency testing data
    R Neill Carey
    The Peninsula Regional Medical Center, Salisbury, MD 21801 5493, USA
    Arch Pathol Lab Med 129:997-1003. 2005
    ..Proficiency testing (PT) participants can interpret their results to detect errors even when their performance is acceptable according to the limits set by the PT provider...
  41. ncbi Why human color vision cannot reliably detect cerebrospinal fluid xanthochromia
    Axel Petzold
    The National Hospital for Neurology and Neurosurgery, Department of Neuroimmunology, Institute of Neurology, Queen Square, London, UK
    Stroke 36:1295-7. 2005
    ..Visual assessment of cerebrospinal fluid (CSF) for xanthochromia (yellow color) is practiced by the majority of laboratories worldwide as a means of diagnosing intracranical bleeds...
  42. ncbi Quality assurance challenge 2
    Manfred Reichenbächer
    Institute of Inorganic and Analytical Chemistry, Friedrich Schiller University, Lessingstrasse, 07743 Jena, Germany
    Anal Bioanal Chem 383:1-2. 2005
    ..Quality assurance is the topic of the present challenge. And please note: there is a prize to be won (a Springer book from our catalogue up to a value of euros 75,-). Please read on.....
  43. ncbi Standardization in laboratory medicine: new challenges
    M Panteghini
    Laboratorio Analisi Chimico Cliniche 1, Azienda Ospedaliera Spedali Civili, 25123 Brescia, Italy
    Clin Chim Acta 355:1-12. 2005
    ....
  44. ncbi The truth about quality: medical usefulness and analytical reliability of laboratory tests
    James O Westgard
    Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USA
    Clin Chim Acta 346:3-11. 2004
    ..It is commonly thought that laboratory tests provide two-thirds to three-fourths of the information used for making medical decisions. If so, test results had better tell the truth about what is happening with our patients...
  45. ncbi Test result variation and the quality of evidence-based clinical guidelines
    Callum G Fraser
    Biochemical Medicine, Ninewells Hospital and Medical School, Tayside University Hospitals NHS Trust, Dundee, Scotland DD1 9SY, UK
    Clin Chim Acta 346:19-24. 2004
    ..Guidelines on cholesterol and high sensitivity C-reactive protein have been examined using these approaches and these investigations allow the following conclusions...
  46. ncbi Guidelines for blood smear preparation and staining procedure for setting up an external quality assessment scheme for blood smear interpretation. Part I: Control material
    Juan Lluis Vives Corrons
    Red Cell Pathology Unit, ICMHO IDIPAPS, Hospital Clinic i Provincial, Barcelona, Spain
    Clin Chem Lab Med 42:922-6. 2004
    ..Most starting external quality organizers set up a scheme for clinical chemistry. Due to a lack of guidance documents, many organizers are reluctant to offer a hematology scheme...
  47. ncbi Bilirubin proficiency testing using specimens containing unconjugated bilirubin and human serum: results of a College of American Pathologists study
    Stanley F Lo
    Reference Standards Laboratory, Department of Pathology and Laboratory Medicine, Children s Hospital of Wisconsin, Milwaukee 53226, USA
    Arch Pathol Lab Med 128:1219-23. 2004
    ..The composition of the specimens, bovine serum enriched with ditaurobilirubin, was responsible for the erroneous results...
  48. ncbi Generic scheme for independent performance assessment in the molecular biology laboratory
    Lyndsey Birch
    BioAnalytical Innovation Team, LGC Ltd, Queens Road, Teddington, Middlesex TW11 0LY, UK
    Clin Chem 50:1553-9. 2004
    ..A variety of proficiency testing schemes are available for specific molecular analyses, but there is an acute need for more widely accessible schemes to assess and demonstrate general competence in DNA analysis...
  49. ncbi Analytical performance and clinical results of a fully automated MEIA system for brain natriuretic peptide assay: comparison with a point of care testing method
    Simona Storti
    Laboratory of Cardiovascular Endocrinology, CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 42:1178-85. 2004
    ..Then, different reference values, as well as cut-off values, should be taken into account for the clinical use of these two immunoassays...
  50. ncbi Effect of analytical quality on establishing common reference intervals and their use
    P Rustad
    Fürst Medical Laboratory, Søren Bulls vei 25, NO 1051 Oslo, Norway
    Scand J Clin Lab Invest 64:399-406. 2004
    ..An interesting outcome was that it was only for the biologically well-regulated quantities serum-sodium and serum-calcium that the selection of the best laboratories gave considerably narrower reference intervals...
  51. ncbi A review of troponin assay performance in Wales: can the same (method-dependent) decision limits be used in different sites?
    M A Thomas
    Quality Laboratory, Cardiff and Vale NHS Trust, Quadrant Centre, Cardiff Business Park, Cardiff, UK
    Ann Clin Biochem 42:351-6. 2005
    ....
  52. ncbi An Italian program of External Quality Control for chromogranin A (CgA) assay: performance evaluation of CgA determination
    Paolo Verderio
    Unit of Medical Statistics and Biometry, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Clin Chem Lab Med 45:1244-50. 2007
    ..This paper reports the results regarding laboratory performance...
  53. ncbi Mistakes encountered during external quality assessment schemes (EQAS): illustrated and categorized examples
    Mathias Maitrejean
    Clin Lab 53:483-4. 2007
  54. ncbi Type B natriuretic peptide stability in frozen plasma
    Massimo Daves
    Clin Chem Lab Med 45:1257-8. 2007
  55. ncbi Standardization of PSA measures: a reappraisal and an experience with WHO calibration of Beckman Coulter Access Hybritech total and free PSA
    G Vignati
    Center of Endocrine and Metabolic Diseases, G Fornaroli Hospital, Magenta, Milan, Italy
    Int J Biol Markers 22:295-301. 2007
    ..Moreover, we have started to provide information to clinicians aimed at the alignment of our results with the WHO standardization...
  56. ncbi Enzymatic assays for creatinine: time for action
    Mauro Panteghini
    Centre for Metrological Traceability in Laboratory Medicine CIRME, University of Milan, Milan, Italy
    Clin Chem Lab Med 46:567-72. 2008
    ....
  57. ncbi Determination of alpha- and beta-amanitin in clinical urine samples by Capillary Zone Electrophoresis
    V A Robinson-Fuentes
    Division de Estudios de Posgrado, Facultad de Ciencias Médicas y Biológicas Dr Ignacio Chávez, Universidad Michoacana de San Nicolas de Hidalgo, Morelia, Michoacan, Mexico
    J Pharm Biomed Anal 47:913-7. 2008
    ..The method here described includes the use of non-aggressive reagents to the capillary or the system and is the first Capillary Electrophoresis method used to determine amanitins in clinical samples...
  58. ncbi Commutable calibrator with value assigned by the IFCC reference procedure to harmonize serum lactate dehydrogenase activity results measured by 2 different methods
    Giampaolo Cattozzo
    A O Ospedale di Circolo e Fondazione Macchi, Varese, Italy
    Clin Chem 54:1349-55. 2008
    ..We sought to verify the commutability of potential calibrator materials and evaluate their effectiveness in harmonizing LDH results by 2 measurement methods...
  59. ncbi Assay validation and biological variation of serum receptor for advanced glycation end-products
    Louise F Brown
    Department of Biochemical Medicine, NHS Tayside, Ninewells Hospital and Medical School, Dundee, UK
    Ann Clin Biochem 45:518-9. 2008
    ..The within- and between-subject components of biological variation were also estimated...
  60. ncbi Principles of quality control
    A A Hurley
    Comprehensive Cytometric Consulting, Ballwin, Missouri, USA
    Curr Protoc Cytom . 2001
    ..This unit presents a brief overview of the principles of quality control in the clinical laboratory...
  61. ncbi Rapid determination of gemcitabine in plasma and serum using reversed-phase HPLC
    Christian Lanz
    Departement fur Innere Medizin, Fachbereich Onkologie Hämatologie, Kantonsspital St Gallen, Switzerland
    J Sep Sci 30:1811-20. 2007
    ..0-18.9 microg/mL) and rats that received lower doses (1.5 mg/kg) via i.v., subcutaneous and oral drug administration (levels: 0.20-2.60 microg/mL). It could also be applied to estimate dFdU levels in human plasma...
  62. ncbi The Lebanese External Quality Assessment Scheme for laboratories: was it worth establishing?
    Ghassan Hallak
    LEQAS, Laboratoires St Elie, Centre Michel Aboujaoudé, Antelias, Lebanon
    J Med Liban 53:9-15. 2005
    ..and 2003, the participants took part in three series of surveys and were asked to analyze between 10 and 23 clinical chemistry analytes...
  63. ncbi Metrological traceability of values for catalytic concentration of enzymes assigned to a calibration material
    Francesca Canalias
    Departament de Bioquimica i Biologia Molecular, Unitat de Bioquímica de Medicina, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Clin Chem Lab Med 44:333-9. 2006
    ..The metrological traceability of values for the catalytic concentration of several enzymes assigned to a calibration material has been assured by following the recently published International Standard ISO 18153...
  64. ncbi Diluent Multiassay for the MODULAR ANALYTICS E170 does not improve TSH dilutions compared to Diluent Universal
    Raúl Fco Rigo
    Clin Chem Lab Med 44:353-4. 2006
  65. ncbi Analysis of laboratory critical value reporting at a large academic medical center
    Anand S Dighe
    Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Clin Pathol 125:758-64. 2006
    ..Factors leading to delays in critical value reporting are identified, and we describe approaches to improving this important operational and patient safety issue...
  66. ncbi On the interpretation of affirmative follow-up tests in immunoassays: what must not be done?
    Adel A A Ismail
    Tanglewood, Chevet Lane, Wakefield, West Yorkshire, WF2 6HL, UK
    Ann Clin Biochem 43:249-51. 2006
    ..Though commendable practice, these extra tests could in some cases lead to a false sense of assurance, misleading clinicians and wasting resources. I would like to highlight the use and misuse of these tests...
  67. ncbi [Improved reliability of critical data exchange between the biological laboratory and clinical centres. Type of data to transfer and identification of the most relevant tools]
    B Dingeon
    Service de Biochimie, Centre Hospitalier de Chambery
    Ann Biol Clin (Paris) 64:381-5. 2006
    ..This paper focuses on the twenty-four hours duty in the hospital at the same level of reliability for alerts...
  68. ncbi [Attending physician must consider uncertainty. Don't let yourself be cheated by the numbers!]
    Anders Kallner
    Karolinska Universitetslaboratoriet, Karolinska Universitetssjuk huset Solna
    Lakartidningen 103:2467-9. 2006
  69. ncbi Wide variability in laboratory reference values for serum testosterone
    Stephen Lazarou
    Harvard Medical School, Division of Urology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Sex Med 3:1085-9. 2006
    ..The laboratory determination of testosterone levels consistent with a diagnosis of hypogonadism is complicated by the availability of multiple testosterone assays and varying reference ranges...
  70. ncbi External quality assessment scheme for hemostasis in India
    Joy Mammen
    Department of Clinical Pathology and Blood Bank, Christian Medical College, Vellore, India
    Semin Thromb Hemost 33:265-72. 2007
    ..The challenges ahead are to increase participation, improve reporting of results, and provide individualized support to laboratories to improve performance when necessary...
  71. ncbi Japanese collaborative study to assess inter-laboratory variation in factor VII activity assays
    O Takamiya
    Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University, Matsumoto, Japan
    J Thromb Haemost 5:1686-92. 2007
    ..Despite its importance, there are no data on the variability of inter-laboratory determinations of low to very low plasma FVII activity (FVII:C)...
  72. ncbi Toward metrological traceability in the determination of prostate-specific antigen (PSA): calibrating Beckman Coulter Hybritech Access PSA assays to WHO standards compared with the traditional Hybritech standards
    Carsten Stephan
    Department of Urology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Clin Chem Lab Med 46:623-9. 2008
    ....
  73. ncbi Descriptive analytical data and consequences for calculation of common reference intervals in the Nordic Reference Interval Project 2000
    P Rustad
    Fürst Medical Laboratory, Søren Bulls vei 25, NO 1051 Oslo, Norway
    Scand J Clin Lab Invest 64:343-70. 2004
    ..reference values on enzymes were accepted that were obtained by applying the International Federation of Clinical Chemistry (IFCC) compatible methods (37 degrees C), while "calibrator"-corrected reference values were used in the ..
  74. ncbi The role, duties and responsibilities of technologists in the clinical laboratory
    John Wood
    Department of Chemical Pathology, Southampton University Hospitals, NHS Trust, Tremona Rd, SO16 6YD, Southampton, UK
    Clin Chim Acta 319:127-32. 2002
    ..This has changed the role of the technologist, encouraging them to broaden their knowledge and take on new skills and responsibility...
  75. ncbi Evaluation of Cobas Integra 800 under simulated routine conditions in six laboratories
    Francisco L Redondo
    Hospital Central de la Cruz Roja, Madrid, Spain
    Clin Chem Lab Med 41:365-81. 2003
    ..Integra 800 fulfilled the proposed quality specifications regarding imprecision of analytical systems for clinical chemistry with few exceptions...
  76. ncbi Grading of laboratories on CD4+ T-lymphocyte evaluations based on acceptable data boundaries defined by the measurement error
    Annalisa Kunkl
    Department of Immunology, San Martino Hospital and University of Genoa, Largo R Benzi 10, 16132 Genoa, Italy
    Cytometry 50:117-26. 2002
    ..We addressed the definition of limits of error of %CD4+ and CD4+ counts (AbsCD4+) typical of laboratories of excellence, as well as the grading of laboratories based on the decision to take these limits as boundaries of unacceptable data...
  77. ncbi Duties and responsibilities of laboratory scientists
    Eleftherios P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Clin Chim Acta 319:111-5. 2002
    ..The new developments in science and technology suggest that we are yet to realize the best times of this exciting profession...
  78. ncbi Length of sedimentation reaction in blood: a comparison of the test 1 ESR system with the ICSH reference method and the sedisystem 15
    Adolfo Romero
    Department of Haematology, H C U Virgen de la Victoria, Malaga, Spain
    Clin Chem Lab Med 41:232-7. 2003
    ..In addition, due to its operational characteristics (60 samples/20 min) it is a suitable tool for clinical laboratories with a high work load as well as for emergency laboratories...
  79. ncbi Thailand intensive external quality assessment schemes as dynamic tools for improving laboratory quality and standard
    Amarin Prijavudhi
    Department of Clinical Chemistry, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand
    Southeast Asian J Trop Med Public Health 33:14-7. 2002
    ..has provided wider EQA schemes, servicing participants all around Thailand, including 400 labs in clinical chemistry of EQAC scheme, 150 labs in clinical hormone of EQAH scheme, 200 labs in clinical microscopy of EQAM scheme, ..
  80. ncbi External quality assessment scheme and laboratory accreditation in Indonesia
    Ina S Timan
    Clinical Pathology Department, Faculty of Medicine, University of Indonesia Cipto Mangunkusumo Hospital, Jakarta, Indonesia
    Rinsho Byori 50:126-30. 2002
    ..The first trial was for clinical chemistry test with 2 cycles per year, followed by the hematology NEQAS in 1986 in collaboration with WHO-Royal Post ..
  81. ncbi Are results of fibrinogen measurements transferable?
    Anders Kallner
    Department of Surgical Sciences, Coagulation Research, Karolinska Institutet, Stockholm, Sweden
    Clin Chem Lab Med 41:804-8. 2003
    ..The commutability of available calibrators and reference materials (including the WHO 2nd IS) was only 50-80% except for one of the calibrators for which the virtual concentration coincided with that obtained by the syneresis method...
  82. ncbi Pilot external quality assessment survey for post-market vigilance of in vitro diagnostic medical devices and investigation of trueness of participants' results
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Gent, Belgium
    Clin Chem Lab Med 41:183-6. 2003
    ..The survey pointed out to the other participants, interchanging instrument, reagent and calibrator, that they are themselves responsible for the problems shown and hence also for problem-solving...
  83. ncbi Accuracy and precision of the Cholestech LDX System in monitoring blood lipid levels
    Jennifer Santee
    Division of Pharmacy Practice, M3 C19 Medical School Building, School of Pharmacy, University of Missouri Kansas City, 2411 Holmes, Kansas City, MO 64108, USA
    Am J Health Syst Pharm 59:1774-9. 2002
  84. ncbi The external quality assessment schemes in Thailand
    Nisarat Opartkiattikul
    Department of Clinical Pathology, Mahidol University, Bangkok, Thailand
    Rinsho Byori 50:121-5. 2002
    ..This includes hematology, clinical chemistry, clinical immunology, clinical microscopy, clinical microbiology and blood banking...
  85. ncbi Upper reference limit, analytical quality specifications and clinical use of haemoglobin A1C
    L G M Jørgensen
    Clinical Biochemistry, The Laboratory Centre, Vejle County Hospital, Vejle, Denmark
    Scand J Clin Lab Invest 62:609-22. 2002
    ..2 HbA1c% and a s(biological) of 0.3 HbA1c%. Based on criteria for sharing common reference intervals and clinical utility, we accepted that the bias and s(analytical) should both be < 0.3 HbA1c% at the level of 7.0 HbA1c%...
  86. ncbi Field-testing and validation in a primary care setting of a point-of-care test for C-reactive protein
    David A Seamark
    Honiton Research Practice, Marlpits Lane, Honiton EX14 2NY, UK
    Ann Clin Biochem 40:178-80. 2003
    ..Use of point-of-care testing (POCT) in primary care has increased. There is a need for high-quality field evaluation of POCT before deployment can be considered...
  87. ncbi Proficiency testing performance: a case study with modeling
    Jennifer M Waugh
    Division of Clinical Laboratories, Kingston General Hosital, Kingston, Ontario K7L 3N6, Canada
    Clin Biochem 35:447-53. 2002
    ..In this case report, current PT performance was assessed and modeling performed to prioritize our quality improvement efforts...
  88. ncbi Accuracy of three dry-chemistry methods for lipid profiling and risk factor classification
    Daniela A Rubin
    Department of Exercise and Sport Science, University of North Carolina, Chapel Hill, NC 27599 8700, USA
    Int J Sport Nutr Exerc Metab 13:358-68. 2003
    ..All 3 analyzers provided a good overall risk classification; however, values of HDL-C should be only used for screening purposes...
  89. ncbi Determination of glycerol in plasma by an automated enzymatic spectrophotometric procedure
    R Li
    Department of Clinical Chemistry, Vrije Universiteit Brussel, Belgium
    Clin Chem Lab Med 39:20-4. 2001
    ..Glycerol levels were significantly correlated with free fatty acid levels. This automated enzymatic method is rapid and reliable, and provides greater sensitivity or convenience than previously described procedures...
  90. ncbi [New common reference intervals for clinical chemistry in the Nordic countries. A better basis for clinical assessment and cooperation]
    Per Simonsson
    Klinisk kemi, Universitetssjukhuset MAS, Malmo
    Lakartidningen 101:901-5. 2004
    ..Enzymes were analyzed using methods traceable to IFCC reference methods. The Swedish Society of Clinical Chemistry now recommends its member laboratories to introduce the new reference intervals and new enzyme methods ..
  91. ncbi Internal quality control system for non-stationary, non-ergodic analytical processes based upon exponentially weighted estimation of process means and process standard deviation
    Rob T P Jansen
    Department of Clinical Chemistry, St Annaziekenhuis, Geldrop, The Netherlands
    Clin Chem Lab Med 40:616-24. 2002
    ..Each result was evaluated on-line, and a limit violation was immediately reported. The system has performed satisfactorily in our laboratory for ten analyzers for over 1 year...
  92. ncbi Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration
    J Mordenti
    Department of Experimental Therapeutics, Genentech, Inc, Souty San Francisco, California 94080, USA
    Toxicol Pathol 27:536-44. 1999
    ..ophthalmoscopy, intraocular pressure measurements, clinical observations, body weight, and hematology and clinical chemistry panels...
  93. ncbi Clinical pathology testing recommendations for nonclinical toxicity and safety studies. AACC-DACC/ASVCP Joint Task Force
    K Weingand
    Procter and Gamble Co, Miami Valley Laboratories, Cincinnati, Ohio 45239
    Toxicol Pathol 20:539-43. 1992
    ..To improve these testing guidelines and the resultant safety assessments, the American Association for Clinical Chemistry's Division of Animal Clinical Chemistry and the American Society for Veterinary Clinical Pathology formed a ..
  94. ncbi High-performance liquid chromatography of selenium compounds utilizing perfluorinated carboxylic acid ion-pairing agents and inductively coupled plasma and electrospray ionization mass spectrometric detection
    M Kotrebai
    Department of Chemistry, University of Massachusetts, Amherst 01003-4510, USA
    J Chromatogr A 866:51-63. 2000
    Increasing speciation demands in clinical chemistry, toxicology and nutrition have made the determination of the total elements in a sample inadequate; the amount of an element and the chemical forms in which it is present need to be ..
  95. ncbi Effects of carbon dioxide inhalation on hematology, coagulation, and serum clinical chemistry values in rats
    G L Walter
    MPI Research, Mattawan, Michigan, USA
    Toxicol Pathol 27:217-25. 1999
    ....
  96. ncbi Antihypertensive Drug Therapy. The effect of JNC criteria on prescribing patterns and patient status through the first year
    M H Alderman
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Hypertens 9:413-8. 1996
    ..measures were type of drug first prescribed and the outcomes at the end of 1 year-changes in blood pressure, clinical chemistry measures and therapy, and clinic attendance are dropout rate...
  97. ncbi The use of sodium dodecyl sulfate-polyacrylamide gel electrophoresis to detect renal damage in Sprague-Dawley rats treated with gentamicin sulfate
    G J Kolaja
    Upjohn Company, Drug Safety Research and Clinical Research Laboratories, Kalamazoo, Michigan 49001
    Toxicol Pathol 20:603-7. 1992
    ..Traditional methods for evaluating renal damage by clinical chemistry such as blood urea nitrogen (BUN) and serum creatinine are not sensitive to early, mild changes...
  98. ncbi Clinical pathology in the National Toxicology Program
    M B Thompson
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 20:484-8; discussion 488-9. 1992
    ..Protocols for these studies include specific hematology and clinical chemistry analyses at 3 selected time points in 13-wk studies...
  99. ncbi Comparative 90-day feeding study with low-viscosity white mineral oil in Fischer-344 and Sprague-Dawley-derived CRL:CD rats
    J M Firriolo
    Exxon Biomedical Sciences, Inc, East Millstone, New Jersey 08875, USA
    Toxicol Pathol 23:26-33. 1995
    ..In the F-344 rats, occasional treatment-related changes were seen in hematology and clinical chemistry parameters...
  100. ncbi Feeding studies in rats with mineral hydrocarbon food grade white oils
    M K Baldwin
    Shell Research Ltd, Sittingbourne Research Centre, Kent, United Kingdom
    Toxicol Pathol 20:426-35. 1992
    ..Rats fed 5,000 ppm or more of either white oil showed dose-related alterations in several hematological and clinical chemistry variates associated mainly with hepatic damage or functional alteration...
  101. ncbi An evaluation of the toxicities of 2'-fluorouridine and 2'-fluorocytidine-HCl in F344 rats and woodchucks (Marmota monax)
    F C Richardson
    NeXstar Pharmaceuticals, Inc, Boulder, Colorado 80301, USA
    Toxicol Pathol 27:607-17. 1999
    ..75 and 7.5 mg/kg/day for 90 consecutive days. Clinical chemistry, hematology, and urinalysis (woodchuck only) profiles were assessed during and at the termination of the ..

Research Grants21

  1. IGFBP5 AND INTEGRINS AND CONTROLLING IGF1 ACTIONS
    David Clemmons; Fiscal Year: 2002
    ....
  2. NOVEL CONTRACEPTIVES WITH ANTI-HIV ACTIVITY
    OSMOND D CRUZ; Fiscal Year: 2001
    ..The preclinical data on in vivo efficacies of WHI-05 and WHI-07 will be essential to further explore the utility of these novel drugs for clinical studies in human patients. ..
  3. PHI-443: Novel Non-Spermicidal Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of PHI-443 in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  4. Phase II SBIR: WHI-07: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ....
  5. Stampidine: A Novel Broad-Spectrum Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of STAMP in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  6. PHI 346: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Following successful completion of the Phase I in vivo efficacy studies, gel formulation of PHI-346 will be further explored as a vaginal dual-function microbicide in Phase II. ..
  7. FLP-102: Rationally Engineered Antiviral Protein
    OSMOND D CRUZ; Fiscal Year: 2003
    ..The preclinical data on FLP-102 will be essential to further explore the utility of this novel recombinant PAP mutant for Phase II. ..
  8. Vanadocenes as a New Class of Spermicidal Drugs
    OSMOND D CRUZ; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  9. METVAN: A Novel Anticancer Agent
    OSMOND D CRUZ; Fiscal Year: 2003
    ..The knowledge gained from these studies described under Specific Aims 1-2 is expected to facilitate the design of innovative treatment regimens employing METVAN for metastatic breast cancer and brain tumor patients. ..
  10. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  11. Chaperones, ROS systems, & IGF-1:Roles in vascular aging
    David Clemmons; Fiscal Year: 2008
    ..abstract_text> ..
  12. A New Biomarker for Ovarian Cancer Detection
    Eleftherios Diamandis; Fiscal Year: 2003
    ..In this grant proposal, we describe further studies, which will examine in greater detail, the ability of a test for the amount of this protein in blood to correctly diagnose the presence of ovarian cancer. ..
  13. PROSTATIC STEROIDS AND SECOND MESSENGERS
    William Rosner; Fiscal Year: 2001
    ....
  14. MECHANISMS BY WHICH IGF-I STIMULATES SMOOTH MUSCLE CELLS
    David Clemmons; Fiscal Year: 2007
    ..The results may suggest novel strategies for interfering with these processes to alter the progression of atherosclerosis. ..
  15. Novel Anticoagulant Mechanisms
    MARY HEEB; Fiscal Year: 2006
    ..We will find whether a ZPI polymorphism we identified affects function. ..
  16. New Aminoglycosides to Treat Drug-Resistant Bacteria
    STEVEN SUCHECK; Fiscal Year: 2003
    ..aeruginosa, Enterococci sp., E.coli, and S. aureus. iv) Identify a few promising lead compounds for advancement into in vivo efficacy studies, safety studies and ultimately clinical development. ..
  17. Human Subjects Research Enhancements Programs
    William Rosner; Fiscal Year: 2002
    ..All such monthly reviews and quizzes will be archived for review. All of the above activities will be designed to be continued after the completion of the initial year of support. ..
  18. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003
    ..If successful, our research will contribute to the development of new prostatic biomarkers and possibly, to better diagnosis which may lead to better clinical outcomes and reduced healthcare costs. ..
  19. ARTHEROSCLEROSIS IN INSULIN-RESISTANT, HYPERLIPIDEMIC P*
    David Clemmons; Fiscal Year: 2005
    ....
  20. FORMS OF PROSTATE SPECIFIC ANTIGEN AND HK2 IN CANCER
    MARY HEEB; Fiscal Year: 2003
    ..Techniques will include protein purification, antibody and ELISA development, immunoblotting, enzyme activity assays, and peptide synthesis. ..
  21. Development of a Novel Method for Inhibiting Atherosclerosis in Diabetes
    David Clemmons; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..