chemistry

Summary

Top Publications

  1. pmc The influence of global climate change on the scientific foundations and applications of Environmental Toxicology and Chemistry: introduction to a SETAC international workshop
    Ralph G Stahl
    DuPont, Wilmington, DE, USA
    Environ Toxicol Chem 32:13-9. 2013
  2. ncbi Structural biology and chemistry of the terpenoid cyclases
    David W Christianson
    Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104 6323, USA
    Chem Rev 106:3412-42. 2006
  3. ncbi Chemistry of carbon nanotubes
    Dimitrios Tasis
    Department of Materials Science, University of Patras, 26504 Rio Patras, Greece
    Chem Rev 106:1105-36. 2006
  4. ncbi Power ultrasound in organic synthesis: moving cavitational chemistry from academia to innovative and large-scale applications
    Giancarlo Cravotto
    Dipartimento di Scienza e Tecnologia del Farmaco, Universita di Torino, via P Giuria 9, I 10125 Torino, Italy
    Chem Soc Rev 35:180-96. 2006
  5. pmc Metal transport across biomembranes: emerging models for a distinct chemistry
    JOSE M ARGUELLO
    Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, Massachusetts 01609, USA
    J Biol Chem 287:13510-7. 2012
  6. pmc From genomics to chemical genomics: new developments in KEGG
    Minoru Kanehisa
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Nucleic Acids Res 34:D354-7. 2006
  7. ncbi Microfluidics: applications for analytical purposes in chemistry and biochemistry
    Ken ichi Ohno
    Institute for Analytical Sciences, Dortmund, Germany
    Electrophoresis 29:4443-53. 2008
  8. pmc Dovetailing biology and chemistry: integrating the Gene Ontology with the ChEBI chemical ontology
    David P Hill
    Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, ME 04609, USA
    BMC Genomics 14:513. 2013
  9. pmc Effects of a distal mutation on active site chemistry
    Lin Wang
    Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
    Biochemistry 45:1383-92. 2006
  10. pmc Dendrimers and supramolecular chemistry
    Jean M J Frechet
    Department of Chemistry, University of California, Berkeley, CA 94720 1460, USA
    Proc Natl Acad Sci U S A 99:4782-7. 2002

Research Grants

  1. Capillary Electrophoresis and Protein Biophysics
    George M Whitesides; Fiscal Year: 2010
  2. Tools To Study Cell Motility and Ion Channels
    George Whitesides; Fiscal Year: 2006
  3. Multivalency: Mechanisms and Applications
    George M Whitesides; Fiscal Year: 2010
  4. MECHANISMS OF ENZYMIC AND HYDRIDE TRANSFERS
    Gregory Petsko; Fiscal Year: 2006
  5. STRUCTURE/FUNCTION OF CARBONIC ANHYDRASE
    David Christianson; Fiscal Year: 2001
  6. SECRETIONS OF ARTHROPODS
    Thomas Eisner; Fiscal Year: 2008
  7. Anti-inflammatory Natural Product Mode of Action Studies
    CRAIG CREWS; Fiscal Year: 2008
  8. Natural Product Model of Action Studies
    CRAIG CREWS; Fiscal Year: 2008
  9. Metabolism of Carcinogens and Drugs by Human P450s
    F Guengerich; Fiscal Year: 2005
  10. STRUCTURE/FUNCTION OF EPOXIDE HYDROLASE
    David Christianson; Fiscal Year: 2005

Detail Information

Publications211 found, 100 shown here

  1. pmc The influence of global climate change on the scientific foundations and applications of Environmental Toxicology and Chemistry: introduction to a SETAC international workshop
    Ralph G Stahl
    DuPont, Wilmington, DE, USA
    Environ Toxicol Chem 32:13-9. 2013
    This is the first of seven papers resulting from a Society of Environmental Toxicology and Chemistry (SETAC) international workshop titled "The Influence of Global Climate Change on the Scientific Foundations and Applications of ..
  2. ncbi Structural biology and chemistry of the terpenoid cyclases
    David W Christianson
    Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104 6323, USA
    Chem Rev 106:3412-42. 2006
  3. ncbi Chemistry of carbon nanotubes
    Dimitrios Tasis
    Department of Materials Science, University of Patras, 26504 Rio Patras, Greece
    Chem Rev 106:1105-36. 2006
  4. ncbi Power ultrasound in organic synthesis: moving cavitational chemistry from academia to innovative and large-scale applications
    Giancarlo Cravotto
    Dipartimento di Scienza e Tecnologia del Farmaco, Universita di Torino, via P Giuria 9, I 10125 Torino, Italy
    Chem Soc Rev 35:180-96. 2006
    Ultrasound, an efficient and virtually innocuous means of activation in synthetic chemistry, has been employed for decades with varied success...
  5. pmc Metal transport across biomembranes: emerging models for a distinct chemistry
    JOSE M ARGUELLO
    Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, Massachusetts 01609, USA
    J Biol Chem 287:13510-7. 2012
    ..Here, we discuss how these characteristics shape novel transition metal ion transport models...
  6. pmc From genomics to chemical genomics: new developments in KEGG
    Minoru Kanehisa
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Nucleic Acids Res 34:D354-7. 2006
    ..Additionally, drug information is now stored separately and linked to new KEGG DRUG structure maps...
  7. ncbi Microfluidics: applications for analytical purposes in chemistry and biochemistry
    Ken ichi Ohno
    Institute for Analytical Sciences, Dortmund, Germany
    Electrophoresis 29:4443-53. 2008
    ..we present recent advancements and novel developments in fluidic systems for applied analytical purposes in chemistry, biochemistry, and life science in general that employ and reflect the full benefits of microfluidics...
  8. pmc Dovetailing biology and chemistry: integrating the Gene Ontology with the ChEBI chemical ontology
    David P Hill
    Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, ME 04609, USA
    BMC Genomics 14:513. 2013
    ....
  9. pmc Effects of a distal mutation on active site chemistry
    Lin Wang
    Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
    Biochemistry 45:1383-92. 2006
    ....
  10. pmc Dendrimers and supramolecular chemistry
    Jean M J Frechet
    Department of Chemistry, University of California, Berkeley, CA 94720 1460, USA
    Proc Natl Acad Sci U S A 99:4782-7. 2002
  11. ncbi Opportunities at the interface of chemistry and biology
    A B Martin
    The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Cell Biol 9:M24-8. 1999
    The combination of the tools and principles of chemistry, together with the tools of modern molecular biology, allow us to create complex synthetic and natural molecules, and processes with novel biological, chemical and physical ..
  12. pmc The role of energy in the emergence of biology from chemistry
    Daria V Dibrova
    School of Physics, University of Osnabruck, 49069 Osnabruck, Germany
    Orig Life Evol Biosph 42:459-68. 2012
    Any scenario of the transition from chemistry to biology should include an "energy module" because life can exist only when supported by energy flow(s)...
  13. doi "Greening Chemistry"--in Turin and the world
    Gabriele Centi
    ChemSusChem 1:663. 2008
  14. ncbi Molecular recognition and supramolecular chemistry in the gas phase
    C A Schalley
    Kekulé Institut für Organische Chemie und Biochemie der Universität, Gerhard Domagk Str 1, D 53121 Bonn, Germany
    Mass Spectrom Rev 20:253-309. 2001
    Supramolecular chemistry, in particular, the fields of molecular recognition and self-assembly, profit much from the development of soft ionization techniques and advanced methods for mass analysis and gas-phase chemistry...
  15. ncbi Aspects of positron emission tomography radiochemistry as relevant for food chemistry
    F Wuest
    Positron Emission Tomography Center, Institute of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf, Dresden, Germany
    Amino Acids 29:323-39. 2005
    ..This exciting but rather new research field of PET would provide new insights and perspectives on food chemistry by assessing quantitative information on pharmocokinetics and pharmacodynamics of food ingredients and dietary ..
  16. ncbi Coordination chemistry strategies for dynamic helicates: time-programmable chirality switching with labile and inert metal helicates
    Hiroyuki Miyake
    Department of Chemistry, Graduate School of Science, Osaka City University, Sugimoto, Osaka 558 8585, Japan
    Chem Soc Rev 41:6977-91. 2012
    ..of organic foldamers and their hybrids with natural helices have been developed, we highlight coordination chemistry strategies for development of structurally and functionally defined metal helicates...
  17. ncbi Artificial neural networks in biology and chemistry: the evolution of a new analytical tool
    Hugh M Cartwright
    Department of Chemistry, University of Oxford, Physical and Theoretical Chemistry Laboratory, UK
    Methods Mol Biol 458:1-13. 2008
    ..This introductory chapter considers briefly the growth in the use of neural networks and provides some general background in preparation for the more detailed chapters that follow...
  18. ncbi Systems chemistry: logic gates, arithmetic units, and network motifs in small networks
    Nathaniel Wagner
    Department of Chemistry, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Chemistry 15:1765-75. 2009
    ..Furthermore, the simulations reveal trends and characteristics that should be useful as "recipes" for future design of experimental functional motifs and for potential integration into modular circuits and molecular computation devices...
  19. ncbi Combining supramolecular chemistry with biology
    Dana A Uhlenheuer
    Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Den Dolech 2, 5612AZ Eindhoven, The Netherlands
    Chem Soc Rev 39:2817-26. 2010
    Supramolecular chemistry has primarily found its inspiration in biological molecules, such as proteins and lipids, and their interactions. Currently the supramolecular assembly of designed compounds can be controlled to great extent...
  20. ncbi Fluorescence correlation spectroscopy in biology, chemistry, and medicine
    I V Perevoshchikova
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Russia
    Biochemistry (Mosc) 76:497-516. 2011
    ..The goal of this review is to promote the development of FCS in Russia so that this technique could occupy the position it deserves in modern Russian science...
  21. ncbi Electrostatic interactions in cations and their importance in biology and chemistry
    Deborah M Smith
    Department of Chemistry, University of California, Irvine, California 92697 2025, USA
    Org Biomol Chem 4:1195-201. 2006
    ..These conformational biases, along with stereoelectronic effects, can control the stereoselectivity of reactions involving carbocationic intermediates...
  22. ncbi Chem-bioinformatics: comparative QSAR at the interface between chemistry and biology
    Corwin Hansch
    Department of Chemistry, Pomona College, Claremont, California 91711, USA
    Chem Rev 102:783-812. 2002
  23. ncbi JACOB: a dynamic database for computational chemistry benchmarking
    Jack Yang
    Theoretische Organische Chemie, Organisch Chemisches Institut der Westfälische Wilhelms Universität Münster, Corrensstraße 40, 48149 Munster, Germany
    J Chem Inf Model 52:3255-62. 2012
    ..Requested sets of results are then automatically presented as bar graphs, with parameters of the graphs being controllable via the URL. JACOB is currently available at www.wallerlab.org/jacob...
  24. ncbi Branching out of single-molecule fluorescence spectroscopy: challenges for chemistry and influence on biology
    Philip Tinnefeld
    Applied Laserphysics und Laserspectroscopy, Faculty of Physics, University of Bielefeld, Germany
    Angew Chem Int Ed Engl 44:2642-71. 2005
    ....
  25. ncbi Biocatalysis--key to sustainable industrial chemistry
    Roland Wohlgemuth
    Sigma Aldrich, Industriestrasse 25, CH 9470 Buchs, Switzerland
    Curr Opin Biotechnol 21:713-24. 2010
    ..The understanding of the catalytic functions of known and new enzymes is key for the development of new sustainable chemical transformations...
  26. ncbi Chemistry and the worm: Caenorhabditis elegans as a platform for integrating chemical and biological research
    S Elizabeth Hulme
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Angew Chem Int Ed Engl 50:4774-807. 2011
    ..elegans that is chemically relevant. It also describes tools-biological, chemical, and physical-that are available to researchers studying the worm...
  27. ncbi Chemistry Nobel for trio who revealed molecular death-tag
    Jim Giles
    Nature 431:729. 2004
  28. ncbi The chemistry and biology of inhibitors and pro-drugs targeted to glutathione S-transferases
    S Mahajan
    Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, WA 98195 7610, USA
    Cell Mol Life Sci 62:1221-33. 2005
    ..However, design of isoform specificity remains a significant challenge in GST inhibitor development. Strategies for further inhibitor design and their possible limitations, along with potential therapeutic uses, are summarized...
  29. ncbi 100 years of peroxynitrite chemistry and 11 years of peroxynitrite biochemistry
    W H Koppenol
    Laboratorium für Anorganische Chemie, Eidgenossische Technische Hochschule, Zurich, Switzerland
    Redox Rep 6:339-41. 2001
    ....
  30. pmc How large is the metabolome? A critical analysis of data exchange practices in chemistry
    Tobias Kind
    University of California Davis, Genome Center Metabolomics, Davis, CA, USA
    PLoS ONE 4:e5440. 2009
    ..We detail current obstacles to compile such a knowledge base of metabolites...
  31. ncbi A simplified measurement procedure and portable electronic photometer for disposable sensors based on ionophore-chromoionophore chemistry for potassium determination
    A Palma
    Department of Electronics and Computer Technology, Campus Fuentenueva, Faculty of Sciences, University of Granada, 18071 Granada, Spain
    Anal Bioanal Chem 386:1215-24. 2006
    ..The disposable sensor is based on ionophore-chromoionophore chemistry. A colour change in the sensing film is detected by measuring the transmitted intensity with a solid state ..
  32. ncbi Peter Agre, 2003 Nobel Prize winner in chemistry
    Mark A Knepper
    National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room 6N260, 10 Center Drive MSC 1603, Bethesda, MD 20892 1603, USA
    J Am Soc Nephrol 15:1093-5. 2004
    Peter C. Agre, an American Society of Nephrology member, is the recipient of the 2003 Nobel Prize in Chemistry for his discovery of the aquaporin water channels...
  33. pmc Investigation of the effects of surface chemistry and solution concentration on the conformation of adsorbed proteins using an improved circular dichroism method
    Balakrishnan Sivaraman
    Department of Bioengineering, 501 Rhodes Engineering Research Center, Clemson University, Clemson, South Carolina 29634, USA
    Langmuir 25:3050-6. 2009
    ..These methods were then applied to investigate how surface chemistry and solution concentration influence both the amount of adsorbed proteins and their secondary structure...
  34. ncbi Aqueous chemistry of the vanadium(III) (V(III)) and the V(III)-dipicolinate systems and a comparison of the effect of three oxidation states of vanadium compounds on diabetic hyperglycemia in rats
    Peter Buglyo
    Department of Inorganic and Analytical Chemistry, University of Debrecen, P O Box 21, H 4010 Debrecen, Hungary
    Inorg Chem 44:5416-27. 2005
    The aqueous vanadium(III) (V(III)) speciation chemistry of two dipicolinate-type complexes and the insulin-enhancing effects of V-dipicolinate (V-dipic) complexes in three different oxidation states (V(III), V(IV), and V(V)) have been ..
  35. pmc Chemistry in bioinformatics
    Peter Murray-Rust
    Unilever Centre for Molecular Science Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    BMC Bioinformatics 6:141. 2005
    ..This has led to a failure to adopt modern informatics and software techniques and therefore paucity of chemistry in bioinformatics...
  36. ncbi An application of exposure modeling in exposure assessments for a university chemistry teaching laboratory
    Chris Keil
    Environmental Health Program, College of Health and Services, Bowling Green State University, Bowling Green, Ohio 43403, USA
    J Occup Environ Hyg 3:99-106. 2006
    ..The exposure models selected were deemed useful in the assessment of exposure acceptability in these labs...
  37. ncbi Reaction kinetics at very low temperatures: laboratory studies and interstellar chemistry
    I W Smith
    School of Chemistry, The University of Birmingham, Edgbaston, Birmingham B15 2TT, U K
    Acc Chem Res 33:261-8. 2000
    ..In this Account, the CRESU method is described and the relevance of the results discussed...
  38. ncbi The chemistry that preceded life's origin: a study guide from meteorites
    Sandra Pizzarello
    Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287 1604, USA
    Chem Biodivers 4:680-93. 2007
    ..Their analyses offer a unique glimpse into the chemistry of the solar system that preceded life and may have been available to its emergence on the early Earth...
  39. ncbi Chemistry and selection
    Christian de Duve
    Christian de Duve Institute of Cellular Pathology, Brussels
    Chem Biodivers 4:574-83. 2007
    Life is the product of chemistry, which obeys deterministic laws, and of natural selection, which operates on variants offered to it by chance, but may, in a number of cases, have been provided with a sufficiently extensive array of ..
  40. ncbi Chemistry meets proteomics: the use of chemical tagging reactions for MS-based proteomics
    Alexander Leitner
    Department of Analytical Chemistry and Food Chemistry, University of Vienna, Vienna, Austria
    Proteomics 6:5418-34. 2006
    ..Today, chemistry is helping to advance the field of proteomics in numerous ways...
  41. pmc Supramolecular chemistry of dendrimers with functional cores
    Francois Diederich
    Laboratorium fur Organische Chemie, Eidgenossische Technische Hochschule Honggerberg, HCI, CH 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 99:4778-81. 2002
    ..Correspondingly, properties of functional cores such as molecular recognition and catalytic activity are profoundly influenced by the surrounding dendritic branches...
  42. ncbi Chemistry plans a structural overhaul
    Eugene Russo
    Nature 419:4-7. 2002
  43. ncbi Complexity in chemistry
    G M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Science 284:89-92. 1999
    Complexity" is a subject that is beginning to be important in chemistry. Historically, chemistry has emphasized the approximation of complex nonlinear processes by simpler linear ones...
  44. ncbi Internet-based tools for communication and collaboration in chemistry
    Antony J Williams
    ChemZoo Inc, 904 Tamaras Circle, Wake Forest, NC 27587, United States
    Drug Discov Today 13:502-6. 2008
    ..The technologies supporting chemistry, while immature, are fast developing to support chemical structures and reactions, analytical data support and ..
  45. doi Relevance and rigor in premedical education
    Jules L Dienstag
    Harvard Medical School, Boston, USA
    N Engl J Med 359:221-4. 2008
  46. ncbi The leaky pipeline: factors associated with early decline in interest in premedical studies among underrepresented minority undergraduate students
    Donald A Barr
    Department of Sociology, Stanford University, Stanford, California 94305 2047, USA
    Acad Med 83:503-11. 2008
    ..To determine the causes among underrepresented racial and ethnic minority groups (URM) of a decline in interest during the undergraduate years in pursuing a career in medicine...
  47. doi Chemistry for everyone
    Peter Murray-Rust
    Unilever Centre for Molecular Sciences Informatics, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
    Nature 451:648-51. 2008
  48. ncbi The Blue Obelisk-interoperability in chemical informatics
    Rajarshi Guha
    Pennsylvania State University, University Park, Pennsylvania 16804 3000, Jmol Project, USA
    J Chem Inf Model 46:991-8. 2006
    ..blueobelisk.org/) is the name used by a diverse Internet group promoting reusable chemistry via open source software development, consistent and complimentary chemoinformatics research, open data, and ..
  49. ncbi The status of electronic laboratory notebooks for chemistry and biology
    Keith T Taylor
    Elsevier MDL, 2440 Camino Ramon, Suite 300, San Ramon, CA 94583, USA
    Curr Opin Drug Discov Devel 9:348-53. 2006
    ..This article describes some of the early efforts and the recent drivers for ELN adoption. The state of the ELN market in 2005 is also described...
  50. pmc Green chemistry for chemical synthesis
    Chao Jun Li
    Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 105:13197-202. 2008
    Green chemistry for chemical synthesis addresses our future challenges in working with chemical processes and products by inventing novel reactions that can maximize the desired products and minimize by-products, designing new synthetic ..
  51. pmc The KEGG resource for deciphering the genome
    Minoru Kanehisa
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Nucleic Acids Res 32:D277-80. 2004
    ..New efforts are being made to abstract knowledge, both computationally and manually, about ortholog clusters in the KO (KEGG Orthology) database, and to collect and analyze carbohydrate structures in the GLYCAN database...
  52. ncbi A perspective of publicly accessible/open-access chemistry databases
    Antony J Williams
    ChemZoo Inc, 904 Tamaras Circle, Wake Forest, NC 27587, United States
    Drug Discov Today 13:495-501. 2008
    ..For chemists the increasing number of resources they can use to access chemistry-related information provides them a valuable path to discovery of information, one which was previously limited ..
  53. ncbi Nanoscale pipetting for controlled chemistry in small arrayed water droplets using a double-barrel pipet
    Kit T Rodolfa
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom
    Nano Lett 6:252-7. 2006
    We present a new methodology which provides for the miniaturization of one of the most common tools in use in chemistry and biology laboratories today-the micropipet...
  54. ncbi DNA methyltransferase-moderated click chemistry
    Rachel L Weller
    Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53705, USA
    Org Lett 7:2141-4. 2005
    ..We have generated a novel adenosine-derived N-mustard that serves as an efficient synthetic cofactor and allows for subsequent "click" chemistry involving the modified nucleic acid substrate.
  55. pmc Toward complex matter: supramolecular chemistry and self-organization
    Jean Marie Lehn
    Institut de Science et d Ingenierie Supramoleculaires, Universite Louis Pasteur, 67000 Strasbourg, France
    Proc Natl Acad Sci U S A 99:4763-8. 2002
  56. pmc Ab initio quantum chemistry: methodology and applications
    Richard A Friesner
    Department of Chemistry, Columbia University, 3000 Broadway, MC 3110, New York, NY 10025, USA
    Proc Natl Acad Sci U S A 102:6648-53. 2005
    ..A wide range of illustrative applications, focusing on materials science and biology, are discussed briefly...
  57. ncbi Nobel Prize in Chemistry. Mastering macromolecules
    Adrian Cho
    Science 298:527-8. 2002
  58. ncbi The philosophy of chemistry
    Joachim Schummer
    Department of Philosophy, University of South Carolina, Columbia 29208, USA
    Endeavour 27:37-41. 2003
    Although chemistry is by far the largest scientific discipline according to any quantitative measure, it had, until recently, been virtually ignored by professional philosophers of science...
  59. ncbi Water channel proteins: from their discovery in 1985 in Cluj-Napoca, Romania, to the 2003 Nobel Prize in Chemistry
    Gh Benga
    Department of Cell and Molecular Biology, Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca, Romania
    Cell Mol Biol (Noisy-le-grand) 52:10-9. 2006
    ..channel by Benga's group must be properly credited; the omission of Gheorghe Benga from the 2003 Nobel Prize in Chemistry (half of which was awarded to Peter Agre "for the discovery of the water channels") was a new mistake in the ..
  60. pmc Growing applications of "click chemistry" for bioconjugation in contemporary biomedical research
    Kido Nwe
    Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1002, USA
    Cancer Biother Radiopharm 24:289-302. 2009
    This update summarizes the growing application of "click" chemistry in diverse areas such as bioconjugation, drug discovery, materials science, and radiochemistry...
  61. pmc General chemistry: expanding the learning outcomes and promoting interdisciplinary connections through the use of a semester-long project
    Thomas J Wenzel
    Department of Chemistry, Bates College, Lewiston, ME 04240, USA
    CBE Life Sci Educ 5:76-84. 2006
    The laboratory component of a first-semester general chemistry course for science majors is described. The laboratory involves a semester-long project undertaken in a small-group format...
  62. pmc Using workflows to explore and optimise named entity recognition for chemistry
    Balakrishna Kolluru
    National Centre for Text Mining, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, United Kingdom
    PLoS ONE 6:e20181. 2011
    b>Chemistry text mining tools should be interoperable and adaptable regardless of system-level implementation, installation or even programming issues...
  63. ncbi "Multi-component reactions : emerging chemistry in drug discovery" 'from xylocain to crixivan'
    Christopher Hulme
    Department of Small Molecule Drug Discovery, Amgen Inc, Thousand Oaks, CA 91320, USA
    Curr Med Chem 10:51-80. 2003
    With the recent emergence of combinatorial chemistry and high-speed parallel synthesis for drug discovery applications, the multi-component reaction (MCR) has seen a resurgence of interest...
  64. pmc Do author-suggested reviewers rate submissions more favorably than editor-suggested reviewers? A study on atmospheric chemistry and physics
    Lutz Bornmann
    Office of Research Analysis and Foresight, Max Planck Society, Munich, Germany
    PLoS ONE 5:e13345. 2010
    ..Studies have shown that author-suggested reviewers rate manuscripts more favorably than editor-suggested reviewers do...
  65. ncbi Nanoscience, nanotechnology, and chemistry
    George M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Small 1:172-9. 2005
  66. ncbi Molecules as modulators: systems biology challenges chemistry
    Harald Schwalbe
    Chembiochem 5:1311-3. 2004
  67. ncbi Chemical documents: machine understanding and automated information extraction
    Joe A Townsend
    Unilever Centre for Molecular Science Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Org Biomol Chem 2:3294-300. 2004
    ..The task is least difficult for structured documents, such as chemistry department web pages or the output of computational chemistry programs, but requires increasingly sophisticated ..
  68. ncbi Synthesis at the interface of chemistry and biology
    Xu Wu
    Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA
    J Am Chem Soc 131:12497-515. 2009
    ..Here we illustrate the potential of this approach and overview some opportunities and challenges in the coming years...
  69. ncbi Green chemistry: science and politics of change
    Martyn Poliakoff
    School of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK
    Science 297:807-10. 2002
    ..what will be needed for the industry to embrace efforts to make it "greener"? We explore some of the issues raised by the development of "green chemistry" techniques and identify potential barriers to their implementation by industry.
  70. ncbi A computer-aided drug discovery system for chemistry teaching
    Robert Gledhill
    School of Chemistry, University of Southampton, Southampton SO17 1BJ, United Kingdom
    J Chem Inf Model 46:960-70. 2006
    ..This provides access to greater computing power and allows a much more complex and detailed formulation of the drug design problem to be tackled for research, teaching, and learning...
  71. ncbi Alchemy vs. chemistry: the etymological origins of a historiographic mistake
    W R Newman
    Department of History and Philosophy of Science, Indiana University, Bloomington
    Early Sci Med 3:32-65. 1998
    The parallel usage of the two terms "alchemy" and "chemistry" by seventeenth-century writers has engendered considerable confusion among historians of science...
  72. ncbi Structurally homologous beta- and meso-alkynyl amidinium porphyrins
    Joel Rosenthal
    Department of Chemistry, 6 335, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139 4307, USA
    Inorg Chem 46:8668-75. 2007
    ..These divergent behaviors are supported by analysis of the frontier molecular orbitals of the homologous pair with TDDFT...
  73. ncbi Determination of the three-dimensional structure of Gynoside A in solution using NMR and molecular modeling
    Qian Li
    Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, PR China
    Molecules 12:907-16. 2007
    ..Except for some quantitative details the overall structure of Gynoside A in pyridine-d5 shared many common features with that in DMSO-d6. The structure in pyridine-d5 had lower energies than that in DMSO-d6 solution...
  74. ncbi Binding affinity of alkynes and alkenes to low-coordinate iron
    Ying Yu
    Department of Chemistry, University of Rochester, Rochester, NY 14627, USA
    Inorg Chem 45:5742-51. 2006
    ..In nitrogenase, alkynes are reduced while alkenes are unreactive, and this work suggests that the different binding affinities to low-coordinate Fe might explain the differential activity of the enzyme toward these two substrates...
  75. ncbi Electron spin-spin exchange coupling mediated by the porphyrin pi system
    David A Shultz
    Department of Chemistry, North Carolina State University, Raleigh, NC 27695 8204, USA
    Inorg Chem 45:5752-9. 2006
    ..The paramagnetic susceptibility data were fit using a modified Bleaney-Bowers equation to give J(3,solid) = -29 cm(-1) (H = - 2Jŝ(1).ŝ(2)). The antiferromagnetic J values are consistent with the pi topology of the porphyrin ring...
  76. ncbi Semiempirical equations for modeling solid-state kinetics based on a Maxwell-Boltzmann distribution of activation energies: applications to a polymorphic transformation under crystallization slurry conditions and to the thermal decomposition of AgMnO4 cry
    Peter J Skrdla
    Merck and Company, Inc, P O Box 2000, RY818 B221, Rahway, New Jersey 07065 0900, USA
    J Phys Chem B 109:10611-9. 2005
    ..The potential broad applicability of our statistical (i.e., dispersive) kinetic approach makes it a potentially attractive alternative to existing models/approaches...
  77. ncbi C(aryl)-O bond formation from aryl methanesulfonates via consecutive deprotection and S(N)Ar reactions with aryl halides in an ionic liquid
    Hui Xu
    College of Science, Northwest A and F University, Yangling 712100, PR China
    Molecules 12:861-7. 2007
    ..The procedure involves consecutive deprotection of aryl methane-sulfonates and a nucleophilic aromatic substitution (S(N)Ar) with activated aryl halides...
  78. ncbi Alkynyl ruthenium colorimetric sensors: optimizing the selectivity toward fluoride anion
    Jean Luc Fillaut
    UMR 6226 CNRS Université Rennes 1, Sciences Chimiques de Rennes, Avenue du General Leclerc, 35042 Rennes, France
    Inorg Chem 46:5922-32. 2007
    ..TD-DFT calculations rationalize the long-range electronic communication as a main characteristic of the alkynyl ruthenium species and as a key to improve the selectivity of alkynyl ruthenium-based sensors toward anions...
  79. ncbi Catalysis design for ring-opening polymerization of cyclic esters: 1. Group 1 metal and thallium(I) trispyrazolylborate complexes with hemilabile ligands
    Malcolm H Chisholm
    Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA
    Inorg Chem 46:8676-83. 2007
    ..1-7 have been characterized by elemental analysis, NMR spectroscopy, and by single-crystal X-ray studies, the latter of which reveal the versatile modes of binding for this new ligand bearing hemilabile ether appendages...
  80. ncbi Formation of a phosphine-phosphinite ligand in RhCl(PRR'2)[P,P-R'(R)POCH2P(CH2OH)2] and R'H from cis-RhCl(PRR'2)2[P(CH2OH)3] via P-C bond cleavage
    Fabio Lorenzini
    Department of Chemistry, The University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z1
    Inorg Chem 46:8998-9002. 2007
    ..One of the isomers of the PPh(3) system, cis-RhCl(PPh(3))[P,P-P(Ph)(2)OCH(2)P(CH(2)OH)(2)], was structurally characterized (cis refers to the disposition of the P atoms with Ph substituents)...
  81. ncbi Ab initio methods for reactive potential surfaces
    Lawrence B Harding
    Chemistry Division, Argonne National Laboratory, Argonne, IL 60439, USA
    Phys Chem Chem Phys 9:4055-70. 2007
    ..The electronic structure methods used are DFT, MP2, CCSD(T), QCISD(T), CASSCF, CASPT2, and CAS+1+2+QC...
  82. ncbi Chiral expression at the solid-liquid interface: a joint experimental and theoretical study of the self-assembly of chiral porphyrins on graphite
    Mathieu Linares
    Service de Chimie des Materiaux Nouveaux, Universite de Mons Hainaut, 20, Place du Parc, B 7000 Mons, Belgium
    Langmuir 24:9566-74. 2008
    ..Such an arrangement results in the formation of a dense chiral monolayer that is further stabilized by hydrogen bonding with protic solvents...
  83. ncbi Electronic structure of bispidine iron(IV) oxo complexes
    Anna E Anastasi
    Department of Chemistry, University of York, Heslington, York, UK
    Inorg Chem 46:6420-6. 2007
    ..It is shown how this can be used as a design principle to tune the relative stability of the two spin states...
  84. ncbi Reductive defluorination of perfluorooctane sulfonate
    Valeria Ochoa-Herrera
    Department of Chemical and Environmental Engineering, University of Arizona, Tucson, Arizona 85721, USA
    Environ Sci Technol 42:3260-4. 2008
    ..Chromatographic peaks corresponding to branched PFOS isomers disappeared whereas the peak corresponding to linear PFOS was stable. To our knowledge this is the first report of reductive dehalogenation of PFOS catalyzed by a biomolecule...
  85. ncbi Synthesis of pyrrolizidine alkaloids via 1,3-dipolar cycloaddition involving cyclic nitrones and unsaturated lactones
    Sebastian Stecko
    Institute of Organic Chemistry of the Polish Academy of Sciences, Kasprzaka 44 52, 01 224 Warsaw, Poland
    Carbohydr Res 343:2215-20. 2008
    ....
  86. ncbi Intrinsic deuterium kinetic isotope effects in glutamate mutase measured by an intramolecular competition experiment
    Miri Yoon
    Department of Chemistry, University of Michigan, Ann Arbor, MI 48109 1055, USA
    Angew Chem Int Ed Engl 46:8455-9. 2007
  87. ncbi Thermodynamic inhibition profile of a cyclopentyl and a cyclohexyl derivative towards thrombin: the same but for different reasons
    Christof Gerlach
    Institut fur Pharmazeutische Chemie, Philipps Universitat Marburg, Marbacher Weg 6, 35032 Marburg, Germany
    Angew Chem Int Ed Engl 46:8511-4. 2007
  88. ncbi Magnetic excitations in Cu6 and Mn6 hexagons embedded in D3d-symmetric polyoxotungstates
    Noa Zamstein
    Department of Chemistry, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel
    Inorg Chem 46:8851-8. 2007
    ..Evaluation of the Zeeman levels shows that the field applied in the plane of the hexagon fully reduces the effect of the antisymmetric exchange...
  89. ncbi Room-temperature emission from platinum(II) complexes intercalated into zirconium phosphate-layered materials
    Eladio J Rivera
    Department of Chemistry, University of Puerto Rico, P O Box 23346, Rio Piedras, Puerto Rico 00931
    Inorg Chem 46:8569-76. 2007
    ..The accumulated data demonstrate that at high concentrations, [Pt(Me(2)bzimpy)Cl]+ and [Pt(tpy)Cl]+ ions can serve as luminescent pillars inside the ZrP framework...
  90. ncbi Different supramolecular coordination polymers of [N,N'-di(pyrazin-2-yl)-pyridine-2,6-diamine]Ni(II) with anions and solvent molecules as a result of hydrogen bonding
    Gene Hsiang Lee
    Institute of Organic and Polymeric Materials, National Taipei University of Technology, Taipei 106, Taiwan
    Molecules 12:821-31. 2007
    ..The magnetic studies revealed values of g = 2.14 and D = 3.11 cm(-1) for [Ni(H2dpzpda)2](ClO4)2 (1) and g = 2.18 and D = 2.19 cm(-1) for [Ni(H2dpzpda)2](NO3)2 (2), respectively...
  91. ncbi Spectroscopic and computational studies of a Ru(II) terpyridine complex: the importance of weak intermolecular forces to photophysical properties
    Claudio Garino
    Dipartimento di Chimica IFM, Universita di Torino, Via P Giuria 7, I 10125 Torino, Italy
    Inorg Chem 46:8752-62. 2007
    ..A good estimate of the transition energy is also obtained (623 nm, 1.94 eV)...
  92. ncbi Driving forces behind ion-ion correlations
    Mikael Lund
    J Chem Phys 125:236101. 2006
  93. ncbi Theory, measurements, and modeling of OH and HO2 formation in the reaction of cyclohexyl radicals with O2
    Adam M Knepp
    Combustion Research Facility, Mail Stop 9055, Sandia National Laboratories, Livermore, CA 94551 0969, USA
    Phys Chem Chem Phys 9:4315-31. 2007
    ..The results once again emphasize the importance of both direct and indirect components of the kinetics for the production of both HO(2) and OH in radical + O(2) reactions...
  94. ncbi Spectroscopic and computational studies of Ni3+ complexes with mixed S/N ligation: implications for the active site of nickel superoxide dismutase
    Adam T Fiedler
    Department of Chemistry, University of Wisconsin Madison, 1101 W University Avenue, Madison, Wisconsin 53706, USA
    Inorg Chem 46:8511-23. 2007
    ..Our results indicate that the Ni(3+)-S bonds in oxidized NiSOD are significantly stronger than those in 1-3 due to the unique mixed amine/amide ligation that is present at the enzyme active site...
  95. ncbi DNA three-way junction with a dinuclear iron(II) supramolecular helicate at the center: a NMR structural study
    Leonardo Cerasino
    Department of Chemistry, University of Bergen, Allegt 41, Bergen, Norway
    Inorg Chem 46:6245-51. 2007
    ..The unprecedented 3WJ arrangement observed in solution has also been found to exist in the crystal structure of the helicate adduct of [d(CGTACG)2] (Angew. Chem., Int. Ed. 2006, 45, 1227)...
  96. ncbi A statistical thermodynamic approach to sonochemical reactions
    Bernard David
    Universite de Savoie, ESIGEC, LCME, 73 376 Le Bourget du Lac, Cedex, France
    Ultrason Sonochem 15:78-88. 2008
    ..With the help of the literature data, the number of cavitation bubble has been evaluated to 6.2 x 10(15) bubbles L(-1) at 300 kHz, in 15 min. This means that about 1 bubble on 1900000 is efficient for undergoing the sonolysis of CO2...
  97. ncbi Dendrimeric bisphosphonates for multivalent protein surface binding
    Markus Arendt
    Fachbereich Chemie der Universitat, Hans Meerwein Strasse, 35032 Marburg, Germany
    Chem Asian J 1:544-54. 2006
    ..Potential new applications include recombinant protein purification through Arg tags on immobilized dendrimers and on/off switching of protein function by reversible active-site capping of enzymes...
  98. ncbi Novel approaches for the synthesis and activation of thio- and selenoglycoside donors
    Silvia Valerio
    Dipartimento di Chimica Organica e Biochimica, Universita degli Studi di Napoli Federico II, Via Cynthia 4, I 80126 Naples, Italy
    J Org Chem 72:6097-106. 2007
    ..In addition, a novel cheap combined system (stoichiometric NBS and catalytic Bi(OTf)3) has been developed for rapid and efficient activation of a wide variety of thio- and selenoglycoside donors...
  99. ncbi A new approach to problem of enzymatic catalysis based on excited state of proteins and Le Chatelier's principle
    Leonid F Dmitriev
    Cardiology Research Center, 3rd Cherepkovskaya Street 15A, 121552 Moscow, Russia
    Arch Biochem Biophys 464:12-8. 2007
    ..This means that, along with the substrate sorption on the protein, the other aspect of the behavior of the dynamic system should be taken into account...
  100. ncbi Chemical modification of wheat-protein-based natural polymers: formation of polymer networks with alkoxysilanes to modify molecular motions and enhance the material performance
    Xiaoqing Zhang
    CSIRO Manufacturing and Materials Technology, Private Bag 33, Clayton South MDC, Clayton South, Victoria 3169, Australia
    Biomacromolecules 8:1881-9. 2007
    ..For WG-SiB systems, SiB could only form linear linkages, and the higher mobility of the SiB phase caused the systems to display a lower strength improvement with a longer elongation value...
  101. ncbi Algorithm to design aperiodic optical superlattice for multiple quasi-phase matching
    Ming Lu
    Department of Physics, State Key Laboratory on Fiber Optic Local Area Communication Networks and Advanced Optical Communication Systems, Shanghai Jiao Tong University, Shanghai, China
    Appl Opt 46:4138-43. 2007
    ..Especially in comparison with other existing algorithms, a self-adjusting algorithm can eliminate the need to search blindly and is independent of the initial conditions...

Research Grants62

  1. Capillary Electrophoresis and Protein Biophysics
    George M Whitesides; Fiscal Year: 2010
    ....
  2. Tools To Study Cell Motility and Ion Channels
    George Whitesides; Fiscal Year: 2006
    ..The work spans biology, microfabrication, and biophysics, and an important product of the research will be students broadly trained in biological and physical sciences. ..
  3. Multivalency: Mechanisms and Applications
    George M Whitesides; Fiscal Year: 2010
    ....
  4. MECHANISMS OF ENZYMIC AND HYDRIDE TRANSFERS
    Gregory Petsko; Fiscal Year: 2006
    ..abstract_text> ..
  5. STRUCTURE/FUNCTION OF CARBONIC ANHYDRASE
    David Christianson; Fiscal Year: 2001
    ..as well as contrasts in the chemical mechanism of CO2 hydration, and this proposal focuses on the structural chemistry of intramolecular proton transfer in isozymes II, IV, and V...
  6. SECRETIONS OF ARTHROPODS
    Thomas Eisner; Fiscal Year: 2008
    ..Insects are major vectors of disease. An understanding of how insects depend on natural products for regulation of their biotic interactions is of broad applied significance to both medicine and agriculture. [unreadable] [unreadable]..
  7. Anti-inflammatory Natural Product Mode of Action Studies
    CRAIG CREWS; Fiscal Year: 2008
    ..abstract_text> ..
  8. Natural Product Model of Action Studies
    CRAIG CREWS; Fiscal Year: 2008
    ..abstract_text> ..
  9. Metabolism of Carcinogens and Drugs by Human P450s
    F Guengerich; Fiscal Year: 2005
    ..Successful completion of these collective studies should provide better understanding of the ways in which human P450s catalyze oxidation of carcinogens and drugs and the significance of variations in these enzymes. ..
  10. STRUCTURE/FUNCTION OF EPOXIDE HYDROLASE
    David Christianson; Fiscal Year: 2005
    ..The structural chemistry and biology of this domain will help us explore the evolutionary imperative for the covalent linkage of the ..
  11. Antibody Generation of ROS and Macular Degeneration
    Paul Wentworth; Fiscal Year: 2007
    ..3. Specific Aim #3 To determine whether the ACWOP when activated in whole blood, plasma and serum can affect RPE cell survival [unreadable] [unreadable] [unreadable]..
  12. Synchrotron-Based Infrared Microscope for Chemical Imaging of Disease
    Lisa Miller; Fiscal Year: 2007
    ..This instrument will be unique worldwide. [unreadable] [unreadable] [unreadable]..
  13. CHEMISTRY OF ARTHROPOD SECRETIONS
    Jerrold Meinwald; Fiscal Year: 2007
    ..b>Chemistry plays a central role in the lives of arthropods...
  14. Metals and Protein Structure in Protein-Folding Diseases
    Lisa Miller; Fiscal Year: 2007
    ..Finally, we use the local structure and homogeneity of the in situ metal-protein complex to develop a possible mechanism for the complex formation and toxicity. ..
  15. NOVEL GLYCOSIDASE INHIBITORS AS ANTICANCER AGENTS
    BRIAN COPPOLA; Fiscal Year: 2002
    ..g., affinity matrices). ..
  16. STRATEGIES FOR CONTEXT SPECIFIC ANTICANCER THERAPIES
    Julian Simon; Fiscal Year: 2002
    ..the molecular target of the drug and its mechanism of action in coordinated studies that combine synthetic chemistry, cell biology and genetics...
  17. New Synthetic Strategies for Protein Engineering
    Matthew B Francis; Fiscal Year: 2010
    ..been developed that combines protein expression, purification, and characterization with the physical organic chemistry and organic synthesis techniques required for new reaction development...
  18. RECOMBINANT SINGLE DOMAIN & HYBRID PEPTIDASE ANTIBODIES
    Sudhir Paul; Fiscal Year: 2002
    ....
  19. CONTROLLING SIGNAL TRANSDUCTION WITH SYNTHETIC LIGANDS
    Stuart Schreiber; Fiscal Year: 2002
    ....
  20. Development of Etched Modified Capillaries
    JOSEPH PESEK; Fiscal Year: 2002
    ..Microsolv Corporation will undertake a marketing plan to distribute the products for use by companies working in the targeted application areas. ..
  21. SYNTHESIS AND BIOSYNTHESIS IN THE SHIKIMATE PATHWAY
    Bruce Ganem; Fiscal Year: 2003
    ..R-Domain swapping experiments will establish whether feedback control elements in the P/T proteins are interchangeable, and whether different mechanisms are involved. ..
  22. Catalytic Synthesis of alpha-Branched Carbonyl Compounds
    JOSEPH READY; Fiscal Year: 2009
    ..These studies will uncover fundamental principles of chemical reactivity and lead to enantioselective syntheses of valuable chiral building blocks. Access to these compounds, in turn, will facilitate drug discovery and production. ..
  23. Anti-Selectin Blocker for Liver Ischemic Injury
    LUIS TOLEDO PEREYRA; Fiscal Year: 2006
    ..Treatment with TCB-1269 will enhance the quality of life of millions of patients suffering from the large number of maladies associated with ischemia/reperfusion ischemic maladies. [unreadable] [unreadable]..
  24. Biochemical and Structural Studies of RNA-Protein Complexes
    James R Williamson; Fiscal Year: 2010
    ..These studies will provide mechanistic and structural insights into common mechanisms for post-transcriptional gene regulation. ..
  25. Human RNAPII Structure/Function in Pausing & Elongation
    Robert Landick; Fiscal Year: 2009
    ..Our research is aimed at understanding these fundamental mechanisms of transcription elongation. The knowledge gained will increase understanding of the basic molecular biology of human diseases. ..
  26. Investigating the link between the atheronals and aging
    Paul Wentworth; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  27. Proteolytic Antibody HIVcides
    Sudhir Paul; Fiscal Year: 2007
    ..These studies may identify proteolytic antibodies suitable for further development as a topical HIVcide. [unreadable] [unreadable] [unreadable]..
  28. THEORETICAL STUDIES OF PROTEIN FOLDING
    Richard Friesner; Fiscal Year: 2008
    ..Specific biological applications of the methods will involve homology modeling of pharmaceutically interesting targets, such as kinases. [unreadable] [unreadable]..
  29. gp120 covalent analogs as candidate HIV vaccines
    Sudhir Paul; Fiscal Year: 2008
    ..Novel vaccination strategies and HIV-1 neutralizing Abs will emerge from these studies if the physiological barriers to catalytic Ab synthesis can be bypassed. [unreadable] [unreadable]..
  30. Theory of the Chemistry of NO, HNO, OONO-, and RSNO
    KENDALL HOUK; Fiscal Year: 2009
    ..Discoveries about the chemistry and biology of NO and its radical derivatives, especially HNO, continue to explode in the literature...
  31. Molecular Basis for PKR Activation by Viral RNAs
    JOSEPH PUGLISI; Fiscal Year: 2009
    ..The results of this work will explain a central mechanism of gene regulation required for antiviral response and control of cell proliferation. ..
  32. Oxygen-linked Phenol-DNA Adducts
    SHANA STURLA; Fiscal Year: 2008
    ..The candidate will become (July, 2004) an assistant professor of Medicinal Chemistry at the University of Minnesota with an appointment in the Cancer Center. She holds a Ph.D...
  33. Distribution of PCB Atropisomers
    Hans Joachim Lehmler; Fiscal Year: 2008
    ..The long term career goal is to establish Dr. Lehmler as an investigator with independent research status and funding. ..
  34. Open Tubular Capillary Electrochromatography/Mass Spectroscopy
    JOSEPH PESEK; Fiscal Year: 2007
    ..This project focuses on providing a means for the analysis of complex samples found in clinical, biological and pharmaceutical applications. [unreadable] [unreadable] [unreadable]..
  35. INNATE AND Ag-ADAPTED CHEMICALLY REACTIVE ANTIBODIES
    Sudhir Paul; Fiscal Year: 2003
    ..Successful execution of this project will provide insight to the genesis of chemically reactive Abs and potentially validate the use CRAs for inhibition and induction of antigen-specific catalytic Abs. ..
  36. ALKALOID SYNTHESIS VIA (3+2) CYCLOADDITIONS
    BRIAN COPPOLA; Fiscal Year: 2003
    ..side chains, heterosubstituted versions, more conjugated versions, and cyclic versions), each with their unique chemistry and method of preparation...
  37. Pancreatic Stem Cell Induction by Small Molecules
    CRAIG CREWS; Fiscal Year: 2003
    ..g., identification of additional pancreatic stem cell marker proteins via differential gene analysis). ..
  38. Perfluorocarbon Materials As Drug Delivery Vehicles
    Hans Joachim Lehmler; Fiscal Year: 2004
    ..abstract_text> ..
  39. Conference--Nucleic Acid Enzymes
    Robert Landick; Fiscal Year: 2004
    ..The intimate format of the conference is designed to promote free exchange of information and ideas among researchers who work on diverse aspects of the RNA and DNA enzymes - thereby expediting research in both fields. ..
  40. Single Molecule Studies of Enzyme Catalysis
    Gordon Hammes; Fiscal Year: 2005
    ..These experiments are directed at understanding better how enzymes catalyze physiological reactions. A better understanding of enzyme mechanisms is essential for understanding the physiology of disease and the development of new drugs. ..
  41. 500MHz Console Upgrade
    Bruce Ganem; Fiscal Year: 2003
    ..T. McQuade will use NMR in designing new synthetic approaches to highly functionalized polymers; Prof. J. Meinwald will investigate the structures of biologically significant molecules involved in chemical communication. ..
  42. New mitosis specific anticancer agents
    Julian Simon; Fiscal Year: 2005
    ..Through these convergent studies we hope to identify new mitosis-specific anticancer agents, their targets and the contexts in which these compounds are most effective. ..
  43. Ion Selectivity by Heavy Metal Transport ATPases
    JOSE ARGUELLO; Fiscal Year: 2002
    ..Results from these studies will help to establish the mechanism of heavy metal binding to carrier proteins and increase our understanding of heavy metal transport. ..
  44. ORIGINS OF STEREOSELECTIVE CATALYSIS BY ANTIBODIES
    KENDALL HOUK; Fiscal Year: 2002
    ..The research will involve both experimental and computational studies designed to reveal the basic organic chemistry of antibody catalysis, and the development of computational methods to achieve better methods for the ..
  45. High-Throughput Identification of RNA polymerase inhibitors in vivo
    Robert Landick; Fiscal Year: 2006
    ....
  46. Integrity of the Pulmonary Blood-Gas Barrier
    John West; Fiscal Year: 2007
    ..In addition, at the more basic level, this research is devoted to a fundamental biological dilemma of the lung, namely how the blood-gas barrier combines extreme thinness with immense strength. [unreadable] [unreadable]..
  47. CATALYTIC ANTIBODIES FOR TUMOR IMMUNOTHERAPY
    Sudhir Paul; Fiscal Year: 2001
    ..The investigators expect the proposed studies to generate catalytic Fv constructs capable of permanent and efficient inactivation of EGFR, and to establish the validity of using catalytic Abs for tumor immunotherapy. ..
  48. Smart Substrates for Cell Biology and Tissue Engineering
    Milan Mrksich; Fiscal Year: 2006
    ..This program will advance a technology that will have broad impact across several areas in biology and medicine. ..
  49. Conformational linkage during catalysis by TrpRS
    Charles Carter; Fiscal Year: 2005
    ..Ground-state destabilization in TrpRS likely has close analogies with similar phenomena in such enzymes. ..
  50. Initiation of HIV 1 reverse transcription
    JOSEPH PUGLISI; Fiscal Year: 2008
    ..The results of this proposal will have direct impact on our understanding of reverse transcription, and the design of novel strategies to inhibit viral replication. ..
  51. Assemply of the 30S Ribosomal Subunit
    James Williamson; Fiscal Year: 2007
    ..This will allow us to monitor the 30S assembly from a global perspective. [unreadable] [unreadable]..
  52. REDUCED DRUG INTERACTIONS OF AZOLE ANTIFUNGAL DRUGS
    Joseph Gal; Fiscal Year: 2003
    ..abstract_text> ..
  53. Isotopically Labeled Nucleotides for Biomolecular NMR
    James Williamson; Fiscal Year: 2007
    ..In order to make these reagents widely available to the structural biology community, we propose to optimize and scale up production of these reagents for commercial distribution. ..
  54. Structural Role of IF1 in Translation Initiation
    JOSEPH PUGLISI; Fiscal Year: 2004
    ....
  55. Substrates for Mechanistic Studies of Cell Adhesion
    Milan Mrksich; Fiscal Year: 2004
    ..A third effort will use substrates presenting an array of hundreds of peptides to identify new ligands that are important in adhesion and migration. ..
  56. CYTOMIMETIC ORGANIC CHEMISTRY
    FREDRIC MENGER; Fiscal Year: 2007
    This proposal continues and expands current research in the general area of the bio-organic chemistry of lipids with heavy emphasis on understanding the behavior of giant vesicles...
  57. Board of Trustees: Systemic Conflict of Interest at Research Universities
    SHEILA SLAUGHTER; Fiscal Year: 2007
    ..The purpose of examining the COI policies is to identify policies that best address ways to manage institutional and systemic COI. [unreadable] [unreadable] [unreadable]..
  58. HTS for Discovery of Inhibitors of STAR Protein-RNA complexes
    James Williamson; Fiscal Year: 2008
    ..Such validated inhibitors would be powerful tools for functional studies in C. elegans and mice, and the assay should be readily extended to inhibitors of Sam68 once suitable RNA targets have been identified. ..
  59. Total Synthesis of Chloriolin B and Chloriolin C
    JOSEPH READY; Fiscal Year: 2002
    ..This project will also introduce a new method for the asymmetric enantioselective synthesis of five-membered rings and demonstrate its usefulness in complex molecule synthesis. ..
  60. CHEMISTRY AND BIOLOGY OF INSULIN-LIKE VANADIUM COMPOUNDS
    DEBBIE CRANS; Fiscal Year: 2003
    ..The aqueous hydrolytic and redox chemistry of biologically active compounds will be characterized. Aim 2...
  61. Nucleic Acids Gordon Conference, 2007
    JOSEPH PUGLISI; Fiscal Year: 2007
    ..In 2007, we continue the long tradition of mixing speakers in areas of DNA and RNA biology, chemistry and biophysics. These crossroads nurture innovation, creativity and discovery...
  62. Targeting RNA Binding and Nuclear Export of HIV Rev
    James Williamson; Fiscal Year: 2007
    ..and targeting Rev include cell biology, biochemistry, structural biology, biophysics, and synthetic organic chemistry. Using this broad but well-integrated approach, we will address key remaining questions about the mechanism of ..