urination

Summary

Top Publications

  1. pmc The neural control of micturition
    Clare J Fowler
    University College London, Department of Uro Neurology, London, WC1N 3BG, UK
    Nat Rev Neurosci 9:453-66. 2008
  2. pmc Bladder dysfunction in mice with experimental autoimmune encephalomyelitis
    Cengiz Z Altuntas
    Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Neuroimmunol 203:58-63. 2008
  3. ncbi Cholinergic activation of phasic activity in the isolated bladder: possible evidence for M3- and M2-dependent components of a motor/sensory system
    Steven M Finney
    Western General Hospital, Edinburgh, Scotland, UK
    BJU Int 100:668-78. 2007
  4. ncbi Modulation of non-voiding activity by the muscarinergic antagonist tolterodine and the β(3)-adrenoceptor agonist mirabegron in conscious rats with partial outflow obstruction
    James I Gillespie
    The Uro physiology Research Group, The Dental and Medical School, Newcastle University, Newcastle upon Tyne, UK
    BJU Int 110:E132-42. 2012
  5. ncbi Nitric oxide/cyclic guanosine monophosphate signalling mediates an inhibitory action on sensory pathways of the micturition reflex in the rat
    Romain Caremel
    Charles Nicolle Hospital, Department of Urology, Rouen, France
    Eur Urol 58:616-25. 2010
  6. ncbi Mirabegron, a β₃-adrenoceptor agonist for the potential treatment of urinary frequency, urinary incontinence or urgency associated with overactive bladder
    Pradeep Tyagi
    William Beaumont Hospital, Department of Urology, 3811 West 13 Mile Road, Royal Oak, MI 48073, USA
    IDrugs 13:713-22. 2010
  7. pmc Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding
    Thomas Gevaert
    Department of Urology, University Hospital Gasthuisberg, Leuven, Belgium
    J Clin Invest 117:3453-62. 2007
  8. ncbi Afferent fibers of the hypogastric nerves are involved in the facilitating effects of chemical bladder irritation in rats
    T Mitsui
    Department of Urology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Neurophysiol 86:2276-84. 2001
  9. ncbi Diagnostic value of International Prostate Symptom Score voiding-to-storage subscore ratio in male lower urinary tract symptoms
    C H Liao
    Department of Urology, Cardinal Tien Hospital and Fu Jen Catholic University, Taipei, Taiwan
    Int J Clin Pract 65:552-8. 2011
  10. ncbi Non-invasive techniques in the diagnosis of bladder storage disorders
    Fawzy F Farag
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neurourol Urodyn 30:1422-8. 2011

Detail Information

Publications300 found, 100 shown here

  1. pmc The neural control of micturition
    Clare J Fowler
    University College London, Department of Uro Neurology, London, WC1N 3BG, UK
    Nat Rev Neurosci 9:453-66. 2008
    Micturition, or urination, occurs involuntarily in infants and young children until the age of 3 to 5 years, after which it is regulated voluntarily...
  2. pmc Bladder dysfunction in mice with experimental autoimmune encephalomyelitis
    Cengiz Z Altuntas
    Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Neuroimmunol 203:58-63. 2008
    ..sclerosis (MS) develop bladder control problems including urgency to urinate, urinary incontinence, frequency of urination, and retention of urine...
  3. ncbi Cholinergic activation of phasic activity in the isolated bladder: possible evidence for M3- and M2-dependent components of a motor/sensory system
    Steven M Finney
    Western General Hospital, Edinburgh, Scotland, UK
    BJU Int 100:668-78. 2007
    ..To analyse pressure changes induced by muscarinic agonists on the isolated bladder in order to examine whether there are different responses representing different components of a motor/sensory system within the bladder wall...
  4. ncbi Modulation of non-voiding activity by the muscarinergic antagonist tolterodine and the β(3)-adrenoceptor agonist mirabegron in conscious rats with partial outflow obstruction
    James I Gillespie
    The Uro physiology Research Group, The Dental and Medical School, Newcastle University, Newcastle upon Tyne, UK
    BJU Int 110:E132-42. 2012
    ..Such concepts could provide insights into the nature of overactive bladder and the site of action of key therapeutic drugs...
  5. ncbi Nitric oxide/cyclic guanosine monophosphate signalling mediates an inhibitory action on sensory pathways of the micturition reflex in the rat
    Romain Caremel
    Charles Nicolle Hospital, Department of Urology, Rouen, France
    Eur Urol 58:616-25. 2010
    ..Several studies have suggested that nitric oxide (NO) or its downstream signalling could modulate the micturition reflex (MR) by reducing the excitability of bladder afferents...
  6. ncbi Mirabegron, a β₃-adrenoceptor agonist for the potential treatment of urinary frequency, urinary incontinence or urgency associated with overactive bladder
    Pradeep Tyagi
    William Beaumont Hospital, Department of Urology, 3811 West 13 Mile Road, Royal Oak, MI 48073, USA
    IDrugs 13:713-22. 2010
    ....
  7. pmc Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding
    Thomas Gevaert
    Department of Urology, University Hospital Gasthuisberg, Leuven, Belgium
    J Clin Invest 117:3453-62. 2007
    ..These data demonstrate a previously unrecognized role for TRPV4 in voiding behavior, raising the possibility that TRPV4 plays a critical role in urothelium-mediated transduction of intravesical mechanical pressure...
  8. ncbi Afferent fibers of the hypogastric nerves are involved in the facilitating effects of chemical bladder irritation in rats
    T Mitsui
    Department of Urology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Neurophysiol 86:2276-84. 2001
    ..These results suggest that capsaicin-sensitive bladder afferent fibers in the HGN, which travel through the rostral lumbar spinal cord, have a role in urinary frequency caused by chemical bladder irritation...
  9. ncbi Diagnostic value of International Prostate Symptom Score voiding-to-storage subscore ratio in male lower urinary tract symptoms
    C H Liao
    Department of Urology, Cardinal Tien Hospital and Fu Jen Catholic University, Taipei, Taiwan
    Int J Clin Pract 65:552-8. 2011
    ..To investigate the diagnostic value of the International Prostate Symptom Score (IPSS) voiding-to-storage subscore ratio (IPSS-V/S) in male lower urinary tract symptoms (LUTS)...
  10. ncbi Non-invasive techniques in the diagnosis of bladder storage disorders
    Fawzy F Farag
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neurourol Urodyn 30:1422-8. 2011
    ..To review clinical studies thus have been conducted to develop non-invasive diagnostic tools in the storage phase of the micturition cycle...
  11. ncbi The relationship between cognition and sensation in determining when and where to void: the concept of cognitive voiding
    Joan Harvey
    School of Psychology, Newcastle University, Newcastle upon Tyne, UK
    BJU Int 110:1756-61. 2012
    ..OBJECTIVE • To investigate the inter-relationship between conscious decision-making processes and bladder sensation in determining the need, time and place to void..
  12. ncbi On the origins of the sensory output from the bladder: the concept of afferent noise
    James I Gillespie
    The Uro physiology Research Group, The Medical School, The University, Newcastle upon Tyne, UK
    BJU Int 103:1324-33. 2009
    ..The emerging picture is complex, but this complexity must not be negated or oversimplified. It must be embraced and incorporated it into thinking when designing experiments, analysing data, diagnosing patients and evaluating treatment...
  13. pmc Effects of inhibition of the L-arginine/nitric oxide pathway in the rat lower urinary tract in vivo and in vitro
    K Persson
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Br J Pharmacol 107:178-84. 1992
    ..They also suggest that the site of action of L-NAME for inducing bladder hyperactivity in the rat is the outlet region rather than the detrusor muscle...
  14. pmc Integrative control of the lower urinary tract: preclinical perspective
    William C de Groat
    Department of Pharmacology, University of Pittsburgh Medical School, Pittsburgh, PA 15261, USA
    Br J Pharmacol 147:S25-40. 2006
    ..The urothelial cells exhibit 'neuron-like' properties that allow them to respond to mechanical and chemical stimuli and to release transmitters that can modulate the activity of afferent nerves...
  15. ncbi Normative bladder diary measurements: night versus day
    Matthew Parsons
    Birmingham Women s Hospital, Birmingham, United Kingdom, and Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA
    Neurourol Urodyn 26:465-73. 2007
    ..A major objective of this study was to generate age-adjusted reference values against which clinical measurements of nocturia can be compared...
  16. ncbi Prospective, randomized, double-blind study of safety and tolerability of intravesical resiniferatoxin (RTX) in interstitial cystitis (IC)
    Tony Y H Chen
    Centre Hospitalier Universitaire de Sherbrooke, Service d urologie 3001, Canada
    Int Urogynecol J Pelvic Floor Dysfunct 16:293-7. 2005
    ..To determine the safety and tolerability of intravesical resiniferatoxin (RTX) in interstitial cystitis (IC) patients...
  17. pmc Characterization of mouse lumbar splanchnic and pelvic nerve urinary bladder mechanosensory afferents
    Linjing Xu
    Department of Pharmacology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA
    J Neurophysiol 99:244-53. 2008
    ..This knowledge broadens our understanding of the potential roles these two pathways play in conveying mechanical information from the bladder to the spinal cord...
  18. ncbi Diuretic hormone 44 receptor in Malpighian tubules of the mosquito Aedes aegypti: evidence for transcriptional regulation paralleling urination
    C L Jagge
    Department of Entomology, Texas A and M University, College Station, TX 77843 2475, USA
    Insect Mol Biol 17:413-26. 2008
    ..This suggests that target tissue receptor biology is linked to the known periods of release of diuretic hormones from the nervous system pointing to a common up-stream regulatory mechanism...
  19. ncbi Clinical study of reconstructed bladder innervation below the level of spinal cord injury to produce urination by Achilles tendon-to-bladder reflex contractions
    Haodong Lin
    Department of Orthopedic Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai, PR China
    J Neurosurg Spine 10:452-7. 2009
    ..In the present study, the authors analyze the effectiveness of neurogenic bladder reinnervation in patients with SCIs by using Achilles tendon reflexes below the paraplegic level...
  20. ncbi Short-term reproducibility of cystometry and pressure-flow micturition studies in healthy women
    Soren Brostrom
    Department of Gynecology Obstetrics, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Neurourol Urodyn 21:457-60. 2002
    ..To evaluate the reproducibility of cystometry and pressure flow studies in women. We wanted to explore any clinically relevant effect of repeated, same-session cystometry...
  21. ncbi How sudden is a compelling desire to void? An observational cystometric study on the suddenness of this sensation
    Stefan De Wachter
    Department of Urology, Faculty of Medicine, University of Antwerpen, Belgium
    BJU Int 101:1000-3. 2008
    ..To evaluate whether a compelling desire to void (CDV) is always perceived suddenly, or whether it can result from the gradual build-up of bladder-filling sensations...
  22. ncbi Normal voiding patterns assessed by means of a frequency-volume chart
    Charlotte Graugaard-Jensen
    Institute of Clinical Medicine, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark
    Scand J Urol Nephrol 42:269-73. 2008
    ..This study aimed to elucidate the mechanisms behind the diurnal and nocturnal urine output patterns in young and elderly male volunteers. Of particular interest was bladder reservoir function during the day and night...
  23. ncbi Reliability and normal ranges for the Patient's Perception of Intensity of Urgency Scale in asymptomatic women
    Rufus Cartwright
    Department of Urogynaecology, King s College Hospital, London, UK
    BJU Int 105:832-6. 2010
    ..Symptom prevalence (prospective cohort)...
  24. ncbi Characterization of a spinal, urine storage reflex, inhibitory center and its regulation by 5-HT1A receptors in female cats
    Venkateswarlu Karicheti
    Urogenix, Inc, Durham, NC 27709, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1198-208. 2010
    ..SUSRIC is inhibited (disfacilitated) by supraspinal 5-HT(1A) receptors...
  25. ncbi Urine flow is a novel hemodynamic monitoring tool for the detection of hypovolemia
    Micha Y Shamir
    Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, POB 12000, Jerusalem 91120, Israel
    Anesth Analg 112:593-6. 2011
    ..We performed a preliminary evaluation to determine whether urine flow can act as an early and sensitive warning of hypovolemia...
  26. ncbi Central nervous control of micturition and urine storage
    Kimio Sugaya
    Division of Urology, Department of Organ oriented Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    J Smooth Muscle Res 41:117-32. 2005
    ..For micturition to occur, the cerebrum must abate its inhibitory influence on the PMC...
  27. ncbi Experimental colitis in mice and sensitization of converging visceral and somatic afferent pathways
    Kenneth Lamb
    Department of Pharmacology, University of Iowa, Iowa City, Iowa, USA
    Am J Physiol Gastrointest Liver Physiol 290:G451-7. 2006
    ..We conclude that cross talk between afferent visceral and somatic pathways may contribute to the coexistence of pain syndromes...
  28. pmc Bladder inhibition or excitation by electrical perianal stimulation in a cat model of chronic spinal cord injury
    Jicheng Wang
    Department of Urology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    BJU Int 103:530-6. 2009
    ..To test the hypothesis that perianal electrical stimulation (PES) in chronic spinal cord-injured (SCI) cats could induce frequency-dependent inhibitory or excitatory reflex bladder responses...
  29. pmc Sacral dorsal horn neurone activity during micturition in the cat
    Robert R Buss
    Department of Physiology, University of Manitoba, 730 William Avenue, Winnipeg, Manitoba, Canada R3E 3J7
    J Physiol 551:387-96. 2003
    ..The depression of group II neurones may serve to suppress unwanted hindlimb reflexes that could disrupt micturition...
  30. ncbi Convergence of sensory pathways in the development of somatic and visceral hypersensitivity
    Klaus Bielefeldt
    Div of Gastroenterology, Dept of Medicine, Univ of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Am J Physiol Gastrointest Liver Physiol 291:G658-65. 2006
    ....
  31. ncbi Serotonin and norepinephrine involvement in efferent pathways to the urethral rhabdosphincter: implications for treating stress urinary incontinence
    Karl B Thor
    Dynogen Pharmaceuticals, Inc, Durham, North Carolina 27709, USA
    Urology 62:3-9. 2003
    ..Early trials have demonstrated that duloxetine significantly reduces incontinence episodes and is well tolerated in the clinical setting...
  32. pmc Autoimmunity to uroplakin II causes cystitis in mice: a novel model of interstitial cystitis
    Cengiz Z Altuntas
    Department of Urology, University Hospitals, Case Western Reserve University, Cleveland, OH 44106, USA
    Eur Urol 61:193-200. 2012
    ..The pathophysiology of interstitial cystitis (IC) is unknown. Deficits in urothelial cell layers and autoimmune mechanisms may play a role...
  33. ncbi The central nervous system control of micturition in cats and humans
    B F Blok
    Department of Anatomy and Embryology, Faculty of Medical Sciences, University of Groningen, The Netherlands
    Behav Brain Res 92:119-25. 1998
    ..In humans the L-region is especially active in volunteers who tried but did not succeed to micturate. The results suggest that in cats and humans at the brainstem and diencephalic levels micturition is organized in the same way...
  34. ncbi Long-term administration of prazosin improves bladder storage function: results from a study in spontaneously hypertensive rats
    Nobuhiro Haga
    Department of Urology, Fukushima Medical University School of Medicine, Fukushima, Japan
    Int J Urol 18:785-91. 2011
    ..To investigate the effects of long-term administration of the α(1) -adrenoceptor antagonist prazosin on afferent inputs from the lower urinary tract (LUT)...
  35. pmc Evidence of central modulation of bladder compliance during filling phase
    Phillip P Smith
    Department of Surgery, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Neurourol Urodyn 31:30-5. 2012
    ..During attempts to isolate the detrusor contractile component of this filling pressurization, we found that compliance reversibly diminishes under conditions which remove central control from the micturition cycle...
  36. ncbi Rodent models for urodynamic investigation
    Karl Erik Andersson
    Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, NC, USA
    Neurourol Urodyn 30:636-46. 2011
    ..The present review discusses the principles of urodynamics in rodents, techniques, and terminology, as well as some commonly used disease models, and their translational value...
  37. pmc Neuromodulation in a rat model of the bladder micturition reflex
    Xin Su
    Medtronic, Inc, Neuromodulation Research, 7000 Central Ave NE, RCE470, Minneapolis, MN 55432, USA
    Am J Physiol Renal Physiol 302:F477-86. 2012
    ..Lower intensities of stimulation may activate large, fast-conducting fibers and actions through the afferent limb of the micturition reflex arc in SN neuromodulation. Higher intensities may additionally act through the efferent limb...
  38. pmc Involvement of metabotropic glutamate receptor 5 in pudendal inhibition of nociceptive bladder activity in cats
    Jeffrey A Larson
    Department of Urology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Physiol 589:5833-43. 2011
    ..These results indicate that glutamic acid has a transmitter function in bladder and somato-bladder reflex mechanisms and raise the possibility that mGluR5 may be a target for pharmacological treatment of lower urinary tract disorders...
  39. pmc Frequency-dependent selection of reflexes by pudendal afferents in the cat
    Joseph W Boggs
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA
    J Physiol 577:115-26. 2006
    ..The ability to control the two principal functions of the bladder by pudendal nerve stimulation is an exciting prospect for neurorehabilitation...
  40. ncbi Involvement of spinal tachykinin NK1 and NK2 receptors in detrusor hyperreflexia during chemical cystitis in anaesthetized rats
    A Lecci
    Pharmacology Research Department Menarini Pharmaceuticals, Florence, Italy
    Eur J Pharmacol 259:129-35. 1994
    ..abstract truncated at 250 words)..
  41. ncbi Comparison of neural targets for neuromodulation of bladder micturition reflex in the rat
    Xin Su
    Neuromodulation Research, Medtronic Incorporated, 7000 Central Ave NE, Minneapolis, MN 55432, USA
    Am J Physiol Renal Physiol 303:F1196-206. 2012
    ..Comparing the effects of TN and DNC stimulation to our previous results with SN stimulation, SN stimulation produces the largest duration and efficacy of bladder inhibition...
  42. pmc Urethral flow-responsive afferents in the cat sacral dorsal root ganglia
    Andre E Snellings
    Department of Biomedical Engineering, Duke University, Durham, NC 27708 0281, USA
    Neurosci Lett 516:34-8. 2012
    ..These are the first data to characterize the properties of flow-responsive afferents in the cat, and reveal properties that parallel those of other afferents...
  43. ncbi The effect of SC-19220, a prostaglandin antagonist, on the micturition reflex in rats
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Eur J Pharmacol 152:273-9. 1988
    ....
  44. ncbi Does increased urination frequency protect against bladder cancer?
    Debra T Silverman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
    Int J Cancer 123:1644-8. 2008
    Experimental studies suggest that increased urination frequency may reduce bladder cancer risk if carcinogens are present in the urine...
  45. ncbi Effects of CYP-induced cystitis on PACAP/VIP and receptor expression in micturition pathways and bladder function in mice with overexpression of NGF in urothelium
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 48:730-43. 2012
    ..These studies are consistent with target-derived NGF and other inflammatory mediators affecting neurochemical plasticity and the reflex function of micturition pathways...
  46. ncbi Relationships between lower urinary tract symptoms and bladder outlet obstruction: results from the ICS-"BPH" study
    J J de la Rosette
    Department of Urology, University Hospital Nijmegen, The Netherlands
    Neurourol Urodyn 17:99-108. 1998
    ..Pressure and flow studies and symptom profiles measure different aspects of the clinical condition that should be viewed separately in the evaluation and treatment decision of the patient presenting with lower urinary tract symptoms...
  47. pmc Transcriptional and translational plasticity in rodent urinary bladder TRP channels with urinary bladder inflammation, bladder dysfunction, or postnatal maturation
    Liana Merrill
    Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 48:744-56. 2012
    ....
  48. ncbi Defining overactive bladder as hypersensitivity
    Osamu Yamaguchi
    Department of Urology, Fukushima Medical University, Fukushima, Japan
    Neurourol Urodyn 26:904-7. 2007
    ..This hypersensitivity was observed in our patients regardless of urgency episodes. We therefore hypothesized that OAB may be more accurately defined as a hypersensitivity disorder rather than a syndrome characterized by urgency...
  49. ncbi Effect of esmolol on fluid therapy in normovolemia and hypovolemia
    Michael P Kinsky
    Resuscitation Research Laboratory, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555 0801, USA
    Shock 30:55-63. 2008
    ..Esmolol reduced DeltaPV/DeltaEVV. These data suggest that esmolol impairs the vascular retention of fluid and may increase the amount of volume support during fluid resuscitation...
  50. ncbi Endocrine status affects bladder size and postvoid residual urinary volume in mice
    Carla Mucignat-Caretta
    Dipartimento di Anatomia e Fisiologia Umana, Universita di Padova, Padua, Italy
    Horm Behav 46:11-8. 2004
    Urine is one of the major media for intraspecific chemical communication in mice. The urination pattern is dependent both on the mice's hormonal and social status...
  51. ncbi Automated noninvasive measurement of cyclophosphamide-induced changes in murine voiding frequency and volume
    R Wood
    Departments of Obstetrics and Gynecology, Urology and Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Urol 165:653-9. 2001
    ..The method is applicable to murine models of interstitial cystitis, detrusor instability and other abnormal voiding states. It may be used for evaluating potential therapies for such conditions...
  52. ncbi The voltage-gated sodium channel Nav1.9 is required for inflammation-based urinary bladder dysfunction
    Amy M Ritter
    Department of Immunology, Merck Research Labs, Rahway, NJ 06070, United States
    Neurosci Lett 452:28-32. 2009
    ..9 KO mice. We conclude that the Nav1.9 sodium channel provides an important link between inflammatory processes and changes in urodynamic properties that occur during urinary bladder inflammation...
  53. ncbi Antagonism of macrophage migration inhibitory factor decreases cyclophosphamide cystitis in mice
    Pedro L Vera
    The Bay Pines VA Healthcare System, Bay Pines, Florida, USA
    Neurourol Urodyn 29:1451-7. 2010
    ..Therefore, we examined the effects of a MIF tautomerase inhibitor (ISO-1; also blocks biological activity) on cyclophosphamide (CYP)-induced cystitis in mice...
  54. ncbi Pharmacologic perspective on the physiology of the lower urinary tract
    Karl Erik Andersson
    Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden
    Urology 60:13-20; discussion 20-1. 2002
    ..If this component of activation is responsible not only for part of the bladder contractions, but also for the symptoms of the overactive bladder, it should be considered an important target for therapeutic interventions...
  55. pmc Purinoceptors as therapeutic targets for lower urinary tract dysfunction
    Anthony P D W Ford
    Department of Biochemical Pharmacology, Roche Palo Alto, CA 94304, USA
    Br J Pharmacol 147:S132-43. 2006
    ....
  56. ncbi Urine output rate and maximum volume voided in school-age children with and without nocturnal enuresis
    Koen Van Hoeck
    Department of Pediatrics, University Hospital Antwerp, Antwerp, Belgium
    J Pediatr 151:575-80. 2007
    ..To compare urine volumes voided and output rates in prepubertal children with and without monosymptomatic nocturnal enuresis (MNE), to investigate the balance between nocturnal urine output and functional bladder capacity...
  57. ncbi Contrasting effects of WIN 55212-2 on motility of the rat bladder and uterus
    Natalia Dmitrieva
    Program in Neuroscience, Florida State University, Tallahassee, Florida 32306 1270, USA
    J Neurosci 22:7147-53. 2002
    ....
  58. ncbi Regulation of connexin 43 by basic fibroblast growth factor in the bladder: transcriptional and behavioral implications
    Hiromitsu Negoro
    Kyoto University, Kyoto, Japan
    J Urol 185:2398-404. 2011
    ..We addressed the transcriptional and behavioral implications of this axis...
  59. ncbi Spontaneous expulsion of a screw during urination: an unusual complication 9 years after internal fixation of pubic symphysis diastasis
    Martin J Heetveld
    Department of Surgery, Sint Lucas Andreas Hospital, Amsterdam, The Netherlands
    Urology 61:645. 2003
    ..of symphysiolysis and dislocation of the left sacroiliac joint, a screw was spontaneously voided during urination. Unstable plate fixation of the symphysis pubis probably caused screw migration into the bladder, creating a ..
  60. ncbi Phasic non-micturition contractions in the bladder of the anaesthetized and awake rat
    Tomi Streng
    Department of Clinical and Experimental Pharmacology, Lund University Hospital, Sweden
    BJU Int 97:1094-101. 2006
    ....
  61. ncbi Animal models of sacral neuromodulation for detrusor overactivity
    Jean Rodolphe Vignes
    Service de Neurochirugie A, Hopital Pellegrin, 1, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Neurourol Urodyn 28:8-12. 2009
    ..The present article reviews experimental approaches for SN for treatment of detrusor overactivity and provides explanations for the potential acting mechanisms...
  62. pmc Bladder activation by selective stimulation of pudendal nerve afferents in the cat
    Paul B Yoo
    Department of Biomedical Engineering, Duke University, Hudson Hall, Room 136, Box 90281, Durham, NC 27708 0281, USA
    Exp Neurol 212:218-25. 2008
    ..spinal reflexes) activated by selective afferent pudendal nerve stimulation, the latter of which may be applied to restore bladder function in persons with SCI...
  63. ncbi Functional imaging and the central control of the bladder
    Rajesh Bharat Chhaganlal Kavia
    Department of Uro Neurology, Institute of Neurology and National Hospital for Neurology and Neurosurgery, London WC1N 3BG, United Kingdom
    J Comp Neurol 493:27-32. 2005
    ..Further work should aim to examine how the regions interact to achieve urinary continence...
  64. ncbi Voided stain on paper method for analysis of mouse urination
    Y Sugino
    Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Neurourol Urodyn 27:548-52. 2008
    ..To evaluate the usefulness of a quantification method using filter paper for analyzing minute voided urine of the mouse...
  65. ncbi Intravesical glycosaminoglycan replenishment with chondroitin sulphate in chronic forms of cystitis. A multi-national, multi-centre, prospective observational clinical trial
    Jørgen Nordling
    Department of Urology, Copenhagen University Hospital, Herlev, Denmark
    Arzneimittelforschung 58:328-35. 2008
    ....
  66. ncbi Circadian variation of voided volume in normal school-age children
    Koen Van Hoeck
    Paediatric Nephrology, University Hospital Antwerp, Wilrijkstraat 10, Edegem, Belgium
    Eur J Pediatr 166:579-84. 2007
    ..Both plots are promising tools for studying the pathophysiology of voided volume vs. urine output, e.g. in children with nocturnal enuresis...
  67. ncbi Changes in urination/defecation, auditory startle response, and startle-induced ultrasonic vocalizations in rats undergoing morphine withdrawal: similarities and differences between acute and chronic dependence
    Mikhail Kalinichev
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Pharmacol Exp Ther 304:603-9. 2003
    ..Increased urination/defecation, altered startle, and ultrasonic vocalizations (USV) are some signs of the withdrawal syndrome in ..
  68. ncbi The role of spinal and peripheral alpha1- and alpha2-adrenoceptors on bladder activity induced by bladder distension in anaesthetized rat
    M S Jeong
    Department of Urology, Korea University College of Medicine, Seoul, Korea
    BJU Int 85:925-31. 2000
    ....
  69. ncbi The role of the rhabdosphincter in female rat voiding
    Tomi Streng
    Institute of Biomedicine, Department of Anatomy, University of Turku, Turku, Finland
    BJU Int 94:138-42. 2004
    ....
  70. ncbi Preoperative pressure-flow studies: useful variables to predict the outcome of continence surgery
    Giuseppe Alessandro Digesu
    Department of Urogynaecology, King s College Hospital, London, UK
    BJU Int 94:1296-9. 2004
    ....
  71. ncbi Evaluation of a novel method for delivering a synthetic analogue of feline facial pheromone to control urine spraying by cats
    D S Mills
    Animal Behaviour and Cognition Group, University of Lincoln, Caythorpe
    Vet Rec 149:197-9. 2001
    ..Linear regression analysis suggested that there was a significant relationship between the amount of spraying and the duration of the use of FFP...
  72. ncbi Voiding ability using propofol sedation in children undergoing voiding cystourethrograms: a retrospective analysis
    Paul A Merguerian
    Department of Surgery, Sections of Urology and Pediatric Surgery, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
    J Urol 176:299-302. 2006
    ....
  73. ncbi Voiding and sexual dysfunction after deep rectal resection and total mesorectal excision: prospective study on 52 patients
    Peter Sterk
    Clinic for Surgery, Klinikum Kempten Oberallgäu, Robert Weixler Strasse 50, 87439 Kempten, Germany
    Int J Colorectal Dis 20:423-7. 2005
    ....
  74. ncbi Thunderclap headache after micturition in bladder pheochromocytoma
    So Hyang Im
    Department of Neurosurgery, Dongguk University Hospital, Gyeonggi Do, Korea
    Headache 48:965-7. 2008
    ..Bladder pheochromocytoma should be included in the differential diagnosis of recurrent thunderclap headache after micturition or exercises...
  75. ncbi A prospective study of sexual and urinary function before and after total mesorectal excision with autonomic nerve preservation for rectal cancer
    Marc Pocard
    Department of Surgery, Saint Antoine University Hospital, 184 rue du Faubourg Saint Antoine, 75012 Paris, France
    Surgery 131:368-72. 2002
    ..We hypothesize that curative total mesorectal excision (TME) with autonomic nerve preservation (ANP) can be done with high rates of preservation of such function...
  76. ncbi Effects of anesthesia on cystometry and leak point pressure of the female rat
    T W Cannon
    Department of Urology, Loyola University of Chicago Medical Center, Maywood, IL, USA
    Life Sci 69:1193-202. 2001
    ..4 +/- 2.4 cm H2O; urethane: 36.2 +/- 3.9 cm H2O). The results suggest that urethane is preferable to K/X for anesthetized cystometry studies since it more closely simulates normal physiological responses...
  77. ncbi Intravesical adenosine triphosphate stimulates the micturition reflex in awake, freely moving rats
    Raj Kumar Pandita
    Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden
    J Urol 168:1230-4. 2002
    ..We tested the hypothesis that ATP given intravesically can stimulate afferent nerves and initiate the micturition reflex...
  78. ncbi Management of overactive bladder
    Joseph G Ouslander
    Division of Geriatric Medicine and Gerontology, Wesley Woods Center, Center for Health in Aging, Emory University, Atlanta, GA 30329, USA
    N Engl J Med 350:786-99. 2004
  79. pmc Male urine signals social rank in the Mozambique tilapia (Oreochromis mossambicus)
    Eduardo N Barata
    CCMAR CIMAR Laboratório Associado, Universidade do Algarve, Campus de Gambelas, 8005 139 Faro, Portugal
    BMC Biol 5:54. 2007
    ..To investigate whether males use urine during aggressive interactions, we measured urination frequency of dye-injected males during paired interactions between size-matched males...
  80. ncbi Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1
    L A Birder
    Department of Medicine, Laboratory of Epithelial Cell Biology, Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Nat Neurosci 5:856-60. 2002
    ..These findings indicate that TRPV1 participates in normal bladder function and is essential for normal mechanically evoked purinergic signaling by the urothelium...
  81. ncbi Clinical efficacy, safety, and tolerability of once-daily fesoterodine in subjects with overactive bladder
    Christopher Chapple
    The Royal Hallamshire Hospital, Sheffield, UK
    Eur Urol 52:1204-12. 2007
    ..To determine the efficacy, tolerability, and safety of fesoterodine in subjects with overactive bladder (OAB)...
  82. ncbi Tolterodine extended release attenuates lower urinary tract symptoms in men with benign prostatic hyperplasia
    Steven A Kaplan
    Department of Urology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Urol 174:2273-5. discussion 2275-6. 2005
    ....
  83. pmc Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function
    Birthe Schnegelsberg
    Department of Neuroscience, Roche Palo Alto, Palo Alto, California, USA
    Am J Physiol Regul Integr Comp Physiol 298:R534-47. 2010
    ..NGF-overexpressing mice may, therefore, provide a useful transgenic model for exploring the role of NGF in urinary bladder dysfunction...
  84. ncbi Urine as a social signal in the mozambique tilapia (Oreochromis mossambicus)
    O G Almeida
    Centro de Ciencias do Mar, Universidade do Algarve, Campus de Gambelas, 8005 139 Faro, Portugal
    Chem Senses 30:i309-10. 2005
  85. ncbi The ureteric jet doppler waveform as an indicator of vesicoureteric sphincter function in adults and children. An observational study
    Vivian Yee Fong Leung
    Diagnostic Radiology and Organ Imaging Department Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Ultrasound Med Biol 28:865-72. 2002
    ....
  86. ncbi Impaired micturition reflex caused by acute selective dorsal or ventral root(s) rhizotomy in anesthetized rats
    Jiuan Miaw Liao
    Department of Physiology, College of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Neurourol Urodyn 25:283-9. 2006
    ..To clarify the contributions of parasympathetic inputs and outputs to the micturition reflex...
  87. ncbi Afferent bladder nerve activity in the rat: a mechanism for starting and stopping voiding contractions
    Joost le Feber
    Department of Urology, Sector Furore, Room Ee1630, Erasmus MC, P O Box 1738, 3000 DR, Rotterdam, The Netherlands
    Urol Res 32:395-405. 2004
    ..The contraction continues until afferent activity drops below a threshold again as a result of a decreasing volume...
  88. ncbi Threshold for efferent bladder nerve firing in the rat
    E van Asselt
    Department of Urology Urodynamics, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    Am J Physiol 276:R1819-24. 1999
    ..Therefore, we concluded that urethral afferent nerve activity does not play a role in the initiation of bladder contractions; voiding contractions presumably are initiated by bladder afferent nerve activity exceeding a certain threshold...
  89. ncbi Abdominal muscle activity during voiding in female rats with normal or irritated bladder
    Yolanda Cruz
    Dept of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Am J Physiol Regul Integr Comp Physiol 290:R1436-45. 2006
    ..However, we conclude that in female rats, the abdominal muscle is reflexively activated during physiological urine expulsion. On the other hand, bladder irritation is marked by an exaggeration of this abdominal visceromotor reflex...
  90. ncbi Influence of pump compliance (peristaltic vs. infusion) on urodynamic measurement during cystometry in conscious rats
    C Velasco
    Pharmaceutical R and D Division-Recordati S.p.A, Mia M. Civitali I-20148, Milano, Italy
    J Pharmacol Toxicol Methods 45:215-21. 2001
    ..The present findings indicate that cystometrographic parameters obtained during pump-evoked micturition with a system at high compliance (peristaltic pump) are equivalent to those observed during physiological micturition...
  91. ncbi Effects of the atypical neuroleptic clozapine on micturition parameters in anesthetized rats
    P L Vera
    Department of Veterans Affairs Medical Center, University of South Florida, Bay Pines, Florida 33744, USA
    Neurourol Urodyn 20:623-39. 2001
    ....
  92. ncbi Role of a central muscarinic cholinergic pathway for relaxation of the proximal urethra during the voiding phase in rats
    H Masuda
    Department of Urology, School of Medicine, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan
    J Urol 165:999-1003. 2001
    ....
  93. ncbi Clozapine inhibits micturition parameters and the external urethral sphincter during cystometry in anesthetized rats
    P L Vera
    Department of Veterans Affairs Medical Center, R and D Service 151, Bay Pines, FL 33744, USA
    Brain Res 901:219-29. 2001
    ..Clozapine inhibits several urodynamic parameters and inhibits the activity of the external urethral sphincter in anesthetized rats. These effects may help explain the urinary disturbances reported in the clinical literature...
  94. ncbi Central muscarinic mechanisms regulating voiding in rats
    Y Ishiura
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Pharmacol Exp Ther 297:933-9. 2001
    ..t.) indicate that muscarinic excitatory mechanisms are tonically active. These findings raise the possibility that voiding function is regulated by both inhibitory and excitatory cholinergic mechanisms in the central nervous system...
  95. pmc Functional importance of cholinergic and purinergic neurotransmission for micturition contraction in the normal, unanaesthetized rat
    Y Igawa
    Department of Urology, Lund University Hospital, Sweden
    Br J Pharmacol 109:473-9. 1993
    ....
  96. ncbi Functional role of central muscarinic receptors for micturition in normal conscious rats
    Osamu Ishizuka
    Department of Urology, Shinshu University School of Medicine, Matsumoto, Japan
    J Urol 168:2258-62. 2002
    ..We tested if muscarinic receptors within the central nervous system mediate a tonic excitatory influence on voiding in rats and if these receptors can be differently influenced by antimuscarinic drugs...
  97. ncbi Effect of muscarinic antagonists on micturition pressure measured by cystometry in normal, conscious rats
    Ali Reza Modiri
    Department of Pharmacology, Biovitrum, Uppsala, Sweden
    Urology 59:963-8. 2002
    ..To establish an in vivo model to screen new muscarinic antagonists for the treatment of overactive urinary bladder and to calculate the respective ID(50) values...
  98. ncbi Is sensory urgency part of the same spectrum of bladder dysfunction as detrusor overactivity?
    Bernard T Haylen
    St Vincent s Clinic, 438 Victoria Street, 2010, Darlinghurst, N S W, Australia
    Int Urogynecol J Pelvic Floor Dysfunct 18:123-8. 2007
    ..Overall, sensory urgency and detrusor overactivity appear to be part of the same spectrum of bladder dysfunction...
  99. ncbi Effects of saw palmetto extract on micturition reflex of rats and its autonomic receptor binding activity
    Tomomi Oki
    Department of Biopharmacy and Center of Excellence Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    J Urol 173:1395-9. 2005
    ..We examined the effects of saw palmetto extract (SPE) on the rat micturition reflex and on autonomic receptors in the lower urinary tract...
  100. ncbi Influence of temperature on urethra to bladder micturition reflex in the awake ewe
    Helene Combrisson
    Department of Physiology and Therapeutics, Ecole Nationale Veterinaire d Alfort, 7 Avenue Général de Gaulle, 94704 Maisons Alfort, France
    Neurourol Urodyn 26:290-5. 2007
    ..The aim of this study was to investigate whether the urethral reflex first described in awake ewes could also be temperature-dependent...
  101. ncbi Sacral neuromodulation in women with idiopathic detrusor overactivity incontinence: decreased overactivity but unchanged bladder contraction strength and urethral resistance during voiding
    Jan Groen
    Department of Urology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Urol 175:1005-9; discussion 1009. 2006
    ..We evaluated the effect of sacral (S3) nerve neuromodulation on voiding in women with idiopathic detrusor overactivity incontinence...

Research Grants64

  1. Urothelial Differentiation in Interstitial Cystitis
    Monica Liebert; Fiscal Year: 2004
    Interstitial cystitis is a poorly understood syndrome that includes pelvic pain, frequent urination and urinary urgency...
  2. Role of Oxidative Stress in Post-MI Cardiac Failure Associated with Diabetes
    MICHAEL FREDERICK HILL; Fiscal Year: 2013
    ..The injection of STZ in rats leads to the development of hyperglycemia, excessive urination, and loss of weight, all of which mimics human type I diabetes...
  3. Reciprocal Control of Motility and Adherence in UTI
    Harry L Mobley; Fiscal Year: 2013
    ..On the other hand, in patients who have urinary catheters to help with urination, a bacterium called Proteus mirabilis often infects the bladder and causes stones to form there...
  4. Estrogen Regulation in BPH and the Lower Urinary Tract
    WILLIAM ALLEN RICKE; Fiscal Year: 2013
    ..include: new glandular prostatic growth, prostatic urethral narrowing, progressively enlarged bladders, and urination patterns of high frequency and low volume...
  5. Excitation contraction coupling in bladder smooth muscle
    Robert S Moreland; Fiscal Year: 2013
    ..the symptoms increasingly interfere with the quality of life, with lower urinary tract symptoms such as frequent urination, the sensation of incomplete bladder emptying, interrupted orweak urinary stream, and urinary leakage...
  6. The influence of diabetes on M2 muscarinic receptor contractile function
    KIRK JIHYON PAK; Fiscal Year: 2012
    ..contraction of smooth muscle tissue, such as in the bladder or colon, which may contribute to problems with urination and/or digestion...
  7. Architectural Design of the Pelvic Floor Skeletal Muscles
    Marianna Alperin; Fiscal Year: 2013
    ..to serve a complex dual role: provide support to the pelvic viscera and aid in continence, as well as facilitate urination, defecation, and parturition...
  8. Function of Mammalian Single-minded Genes SIM1 and SIM2
    Chen Ming Fan; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Neuroendocrine hormones regulate diverse physiological processes, including urination, lactation, and food intake...
  9. Autonomic Control of Urinary Function in Diabetic Mice
    JOHN DANIEL TOMPKINS; Fiscal Year: 2012
    ..This project will determine which components of the nervous system are damaged by diabetes and lead to problems with urination.
  10. Brain Bladder Interactions in IC/PBS
    LARISSA RODRIGUEZ; Fiscal Year: 2012
    ..chronic bladder syndrome characterized by bladder pain and discomfort (urgency) and increased frequency of urination. It is part of a larger group of chronic functional pain disorders, which also include such common disorders as ..
  11. Combined Behavioral and Drug Treatment of Overactive Bladder in Men
    KATHRYN LARSEN BURGIO; Fiscal Year: 2013
    ..distressing condition that manifests as bothersome lower urinary tract symptoms (LUTS) of urgency, frequent urination, nocturia, or urgency incontinence, and impacts the lives of millions of men...
  12. Improving prostate biopsy efficiency: The finasteride challenge test
    ROBIN JEAN LEACH; Fiscal Year: 2013
    ..the drug finasteride, an inhibitor of the five alpha reductase type 2 enzyme and a medication used to improve urination, PSA was a better predictor of presence of prostate cancer...
  13. Pharmacoepidemiology of Urologic Symptoms
    SUSAN AUDREY HALL; Fiscal Year: 2010
    ..PROJECT NARRATIVE This study is considering whether medical problems having to do with urination or erections might be due to the types of drugs people are taking...
  14. EFFECT OF CRANBERRY CONSTITUENTS ON UTI PATHOGENESIS
    Scott Hultgren; Fiscal Year: 2007
    ..are among the most common bacterial infections, with symptoms that can include dysuria, urgency and frequency of urination, flank pain and fever. Clinical diagnosis is based on symptoms and the laboratory finding of bacteriuria...
  15. Anxiolytic Property of Atypical Antipsychotics
    Ming Li; Fiscal Year: 2009
    ..g., body temperature, defecation, urination, ultrasonic vocalization), which enable evaluation of the anxiolytic properties of various antipsychotics, while ..
  16. Histotripsy for Benign Prostatic Hyperplasia
    William W Roberts; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Prostate enlargement is a common finding in men as they age and causes difficulty with urination. Established treatments to remove this excess tissue and improve urinary drainage require invasive surgery...
  17. MALE UROGENITAL FUNCTION AND CHRONIC SPINAL CORD INJURY
    Charles Hubscher; Fiscal Year: 2009
    Deficits in ejaculation, urination, and defecation are among of the most devastating outcomes of spinal cord injury (SCI), severely affecting quality of life...
  18. NEUROGENIC INFLAMMATION IN INTERSTITIAL CYSTITIS
    Leslie Kushner; Fiscal Year: 2000
    ..IC is a disease of the urinary bladder characterized by extreme frequency of urination, urgency, and pelvic pain. This disease occurs in the population at a frequency of 5...
  19. ROLE OF BIOFEEDBACK IN TREATMENT OF URINARY INCONTINENCE
    Kathryn Burgio; Fiscal Year: 1999
    ..muscle strength, increased use of pelvic muscles in response to the sensation of urgency, reduced frequency of urination, and increased bladder capacity...
  20. BIOMEDICAL RESEARCH SUPPORT GRANT
    JOHN FORDTRAN; Fiscal Year: 1991
    ..Project 1 (CM) examines the structural basis for urination and employs iontophoretic filling of sacral preganglionic neurons with horseradish peroxidase...
  21. STANDARDIZED AND IMPROVED SAW PALMETTO PRODUCT
    TREVOR CASTOR; Fiscal Year: 2000
    ..This condition typically causes frequent urination. The U.S. marketplace is estimated to be $1.3 billion annually...
  22. Urinary Catheters with Multiple Sensing Elements
    YAFAN ZHANG; Fiscal Year: 2002
    ..Thus, multiple parameters such as bladder and urethra pressure during urination may be simultaneously monitored...
  23. In Vivo Ca2+ and Voltage Imaging on The Urinary Bladder
    Michael I Kotlikoff; Fiscal Year: 2010
    ..and psychological consequence, resulting in a complex of symptoms including incontinence, increased frequency of urination, and an inappropriate sense of urinary urgency, all of which appear to result from abnormal contractile activity ..
  24. An investigation of the renal Na-K-CI cotransporter
    MICHELLE MONETTE; Fiscal Year: 2009
    ..Relevance: In humans, the kidney functions to reabsorb salt and water from the body before it is lost via urination, and this task is carried out, in part, by an ion transport protein at the focus of this investigation...
  25. Locomotion Control by Lumbar Spinal Cord Stimulation
    Changfeng Tai; Fiscal Year: 2008
    ..The proposed studies will not only improve our understanding of locomotion control in lumbar spinal cord but also benefit SCI patients. ..
  26. Bladder and Sphincter Control after Spinal Cord Injury
    Changfeng Tai; Fiscal Year: 2008
    ..abstract_text> ..
  27. BOTULINUM TOXIN THERAPY FOR INTERSTITIAL CYSTITIS/CHRON*
    Mary FitzGerald; Fiscal Year: 2007
    ..abstract_text> ..
  28. Sensory Testing in Subjects with Interstitial Cystitis
    Mary FitzGerald; Fiscal Year: 2004
    ..abstract_text> ..
  29. Neuroplasticity of Urinary Tract Disorders after SCI
    William C DeGroat; Fiscal Year: 2010
    ....
  30. Urodynamic and Multiethnic Variability of Men Treated b*
    Steven Kaplan; Fiscal Year: 2005
    ..Baseline urodynamic parameters which may predict improved outcome after MIST 3. The success of various types of MIST in treating BPH in African - American, Hispanic and Caucasian men. ..
  31. Nitric oxide in bladder neural-epithelial signaling
    Lori Birder; Fiscal Year: 2005
    ..Elucidation of mechanisms impacting on urothelial function may provide insights into the pathology of bladder dysfunction. ..
  32. Development of Bioengineered Skeletal Muscle for Functional Replacement in vivo
    GEORGE JOSEPH CHRIST; Fiscal Year: 2010
    ..Tissue engineering of skeletal muscle in vitro for functional tissue replacement in vivo may provide a potential therapeutic solution to this unmet medical need. ..
  33. Neurophysiology and Biomechanics of Urethra in Stress Urinary Incontinence
    Naoki Yoshimura; Fiscal Year: 2008
    ..This is recognized as a high priority in the urologic/gynecologic care of SUI patients. [unreadable] [unreadable]..
  34. AFFERENT PLASTICITY UNDERLYING URETHRAL AND PELVIC PAIN
    Naoki Yoshimura; Fiscal Year: 2010
    ..This is recognized as a high priority in the urologic care of patients with IC/CPPS. ..
  35. Gene therapy for bladder hyperactivity in diabetic rats
    George Christ; Fiscal Year: 2002
    ..In year 2 of this proposal we will study the prophylactic ability and duration of this gene therapy approach. ..
  36. Lower urinary tract dysfunction in Parkinson's disease
    Naoki Yoshimura; Fiscal Year: 2003
    ..This is a high priority in the urologic care of patients with Parkinson's disease. ..
  37. MOLECULAR STUDIES OF EXPERIMENTAL DIABETIC NEUROPATHY
    George Christ; Fiscal Year: 2003
    ..By bringing to bear such a diverse array of techniques on this important medical problem we hope to gain the greatest insight possible into the functional correlates in vivo of well quantified molecular alterations. ..
  38. CAREER LEADERSHIP AWARD
    Joseph Ouslander; Fiscal Year: 2004
    ..The outcomes of each specific aim will be carefully tracked and evaluated utilizing a number of quantitative measures. ..
  39. Bladder Pain Gene Therapy with Pro-opiomelanocortin cDNA
    Naoki Yoshimura; Fiscal Year: 2004
    ..This research project is important to provide a solid basis for potential future clinical application. ..
  40. Minimally Invasive Surgical Therapies Treatment Consort*
    Claus Roehrborn; Fiscal Year: 2005
    ..The MIST Study Group will be a blueprint for a technology assessment group applicable to other areas of urology and other medical or surgical subspecialties. ..
  41. Aging Effects on a-Adrenergic Activity in Female Bladder
    Natalia Dmitrieva; Fiscal Year: 2006
    ..The results of these studies will be the basis for developing a longer research program. ..
  42. Maternal Birth-Related NeuroMuscular Injury and Recovery
    Janis Miller; Fiscal Year: 2006
    ..Our long-term goal is prevention and treatment of incontinence and prolapse, with care based on an improved understanding of the injury responsible for the pathology. ..
  43. EXOGENOUS/ENDOGENOUS CANNABINOIDS--CHEMISTRY & BEHAVIOR
    TORBJORN JARBE; Fiscal Year: 2005
    ....
  44. Study of Intrinsic Bladder Activity by Optical Imaging
    Anthony Kanai; Fiscal Year: 2007
    ..To study the neural-chemical control of spontaneous detrusor activity; and III.) To determine the origin of detrusor overactivity in partially obstructed bladders. ..
  45. Afferent modulation in bladde dysfunction
    Naoki Yoshimura; Fiscal Year: 2007
    ..abstract not provided ..
  46. 2002 Symposium-Functional Genomics of Urogenital System
    George Christ; Fiscal Year: 2003
    ..Overall, we believe this conference will serve important scientific and educational ends and will stimulate new research in the basic understanding of urologic disorders in men and women. ..
  47. VIRTUAL STROKE MODEL FOR STUDY OF BLADDER HYPERREFLEXIA
    Victor Pikov; Fiscal Year: 2005
    ..We hope that this project can lead to development of a better treatment of stroke-related bladder dysfunction. ..
  48. Stromal Epithelial Interactions in Breast Cancer
    Gerald Cunha; Fiscal Year: 2004
    ..To accomplish these goals we will use tissue recombinant technology, cell and organ culture, immunocytochemistry, and various molecular methodologies. ..
  49. BLADDER OUTLET OBSTRUCTION INDUCED NEUROPLASTICITY
    Peter Zvara; Fiscal Year: 2003
    ..lumbosacral spinal cord. Changes in connectivity between the various spinal elements will be assessed following BOO. ..
  50. Breast Cancer Screening and Follow-up in a PBRN: The Ma*
    Michael Barry; Fiscal Year: 2007
    ..We will create a process to track all patients within our PBRN and to reduce current barriers to ordering and following up of abnormal mammogram results. [unreadable] [unreadable]..
  51. ROLE OF ISCHEMIA IN BLADDER OVERACTIVITY AND FIBROSIS
    MIKE SIROKY; Fiscal Year: 2003
    ..Such enhanced understanding may lead to more effective diagnosis, treatment and perhaps even prevention of these problems. ..
  52. Genetics of Interstitial Cystitis
    John Warren; Fiscal Year: 2007
    ..The identification of alleles of susceptibility to IC may reveal clues to pathogenesis, clinical therapy, preventive strategy, and possibly gene therapies. ..
  53. BEAUMONT/FORD INTERSTITIAL CYSTITIS CLINICAL CENTER
    Ananias Diokno; Fiscal Year: 2003
    ..The combination therapy will also potentially reduce the dos of BCG, which will lower the cost and decrease the potential morbidity of this treatment program. ..
  54. EPIDEMIOLOGY OF CHRONIC PELVIC PAIN
    J Clemens; Fiscal Year: 2005
    ..abstract_text> ..
  55. Research Symposium on Functional Abdoninal Pain in Children
    Samuel Nurko; Fiscal Year: 2007
    ..7. To educate the NASPGHAN membership on the state of the art of functional abdominal pain and IBS in children. [unreadable] [unreadable] [unreadable]..
  56. Patient-Oriented Models for Urinary Function in Women
    Linda Brubaker; Fiscal Year: 2008
    ..unreadable] b. To model urinary storage in health and disease [unreadable] c. To model urinary emptying in health and diseas [unreadable] [unreadable]..
  57. Race Differences in Female UI: Epidemiology and Biology
    John DeLancey; Fiscal Year: 2005
    ..Knowledge of these factors can then provide the basis for risk factor identification and the development of preventive strategies appropriate to different racial groups. ..
  58. Neuroscience Center for Biomedical Research Excellence
    Francis W Flynn; Fiscal Year: 2010
    ....
  59. Geriatric Incontinence: The Brain-Bladder Connection
    Derek Griffiths; Fiscal Year: 2006
    ..In either case, the proposed project will shed new light on brain control of the bladder, suggest new diagnostic methods, and provide a crucial step in improving treatment of a morbid and intractable condition. ..
  60. Neurotrophic Mechanisms in LUT Plasticity with Cystitis
    MARGARET VIZZARD; Fiscal Year: 2007
    ..3). To evaluate the physiological roles of PACAP and neurotrophins in the micturition reflex pathway using PACAP knockout mice. ..
  61. Correlation of Urinary Bladder Afferent Activity and Function in Awake Mice
    Peter Zvara; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..