kidney concentrating ability

Summary

Summary: The ability of the kidney to excrete in the urine high concentrations of solutes from the blood plasma.

Top Publications

  1. ncbi Renal concentrating and diluting function in deficiency of specific aquaporin genes
    A S Verkman
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, 94143 0521, USA
    Exp Nephrol 10:235-40. 2002
  2. ncbi Acute endotoxemia in rats induces down-regulation of V2 vasopressin receptors and aquaporin-2 content in the kidney medulla
    Valery Grinevich
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    Kidney Int 65:54-62. 2004
  3. ncbi Urea and urine concentrating ability: new insights from studies in mice
    Baoxue Yang
    Department of Medicine, University of California, San Francisco, California 94143 0521, USA
    Am J Physiol Renal Physiol 288:F881-96. 2005
  4. ncbi Lack of UT-B in vasa recta and red blood cells prevents urea-induced improvement of urinary concentrating ability
    Lise Bankir
    Cardiovascular Research Institute, University of California, 1246 Health Sciences East Tower, San Francisco, CA 94143 0521, USA
    Am J Physiol Renal Physiol 286:F144-51. 2004
  5. pmc The physiology of urinary concentration: an update
    Jeff M Sands
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Semin Nephrol 29:178-95. 2009
  6. ncbi Urinary concentrating ability in patients with Jk(a-b-) blood type who lack carrier-mediated urea transport
    J M Sands
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322
    J Am Soc Nephrol 2:1689-96. 1992
  7. ncbi Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3
    B Yang
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California, 94143 0521, USA
    J Biol Chem 276:624-8. 2001
  8. ncbi Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B
    Baoxue Yang
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 277:10633-7. 2002
  9. ncbi Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion
    Baoxue Yang
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    Am J Physiol Renal Physiol 291:F465-72. 2006
  10. ncbi Mechanisms to concentrate the urine: an opinion
    Mitchell L Halperin
    Division of Nephrology, St Michael s Hospital, University of Toronto, Toronto, Canada
    Curr Opin Nephrol Hypertens 17:416-22. 2008

Detail Information

Publications171 found, 100 shown here

  1. ncbi Renal concentrating and diluting function in deficiency of specific aquaporin genes
    A S Verkman
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, 94143 0521, USA
    Exp Nephrol 10:235-40. 2002
    ..The renal phenotype in aquaporin null mice suggests the utility of aquaporin blockers as novel aquaretic-diuretic agents...
  2. ncbi Acute endotoxemia in rats induces down-regulation of V2 vasopressin receptors and aquaporin-2 content in the kidney medulla
    Valery Grinevich
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    Kidney Int 65:54-62. 2004
    ..To test this hypothesis, we examined the effect of lipopolysaccharide (LPS) injection on the expression of V2 receptors and aquaporin-2 in the kidney...
  3. ncbi Urea and urine concentrating ability: new insights from studies in mice
    Baoxue Yang
    Department of Medicine, University of California, San Francisco, California 94143 0521, USA
    Am J Physiol Renal Physiol 288:F881-96. 2005
    ..On the whole, studies in UT-B null mice suggest that recycling of urea by countercurrent exchange in medullary vessels plays a more crucial role in the overall capacity to concentrate urine than its recycling in the loops of Henle...
  4. ncbi Lack of UT-B in vasa recta and red blood cells prevents urea-induced improvement of urinary concentrating ability
    Lise Bankir
    Cardiovascular Research Institute, University of California, 1246 Health Sciences East Tower, San Francisco, CA 94143 0521, USA
    Am J Physiol Renal Physiol 286:F144-51. 2004
    ....
  5. pmc The physiology of urinary concentration: an update
    Jeff M Sands
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Semin Nephrol 29:178-95. 2009
    ....
  6. ncbi Urinary concentrating ability in patients with Jk(a-b-) blood type who lack carrier-mediated urea transport
    J M Sands
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322
    J Am Soc Nephrol 2:1689-96. 1992
    ....
  7. ncbi Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3
    B Yang
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California, 94143 0521, USA
    J Biol Chem 276:624-8. 2001
    ..The renal function studies indicate independent roles of AQP1 and AQP3 in countercurrent exchange and collecting duct osmotic equilibration, respectively...
  8. ncbi Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B
    Baoxue Yang
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 277:10633-7. 2002
    ..The UT-B null mice generated for these studies should also be useful in establishing the role of facilitated urea transport in extrarenal organs expressing UT-B...
  9. ncbi Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion
    Baoxue Yang
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    Am J Physiol Renal Physiol 291:F465-72. 2006
    ....
  10. ncbi Mechanisms to concentrate the urine: an opinion
    Mitchell L Halperin
    Division of Nephrology, St Michael s Hospital, University of Toronto, Toronto, Canada
    Curr Opin Nephrol Hypertens 17:416-22. 2008
    ..Our goal is to suggest how the renal concentrating mechanism is regulated in vivo...
  11. ncbi Decrease in urinary excretion of aquaporin-2 associated with impaired urinary concentrating ability in diabetic nephropathy
    Tomoatsu Nakamura
    Department of Medicine, Division of Endocrinology and Metabolism, Jichi Medical School, Tochigi, Japan
    Nephron 92:445-8. 2002
    ....
  12. pmc Urinary concentration and dilution in the aging kidney
    Jeff M Sands
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Semin Nephrol 29:579-86. 2009
    ..If similar mechanisms occur in human kidneys, it would provide a molecular explanation for the reduced concentrating ability in aging and may provide opportunities for novel therapeutic approaches to improve urine concentrating ability...
  13. ncbi Downregulation of renal vasopressin V2 receptor and aquaporin-2 expression parallels age-associated defects in urine concentration
    Ying Tian
    Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, DC 20007, USA
    Am J Physiol Renal Physiol 287:F797-805. 2004
    ....
  14. pmc Downregulation of UT-A1/UT-A3 is associated with urinary concentrating defect in glucocorticoid-excess state
    Chunling Li
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Am Soc Nephrol 19:1975-81. 2008
    ....
  15. ncbi Vasopressin-independent renal urinary concentration: increased rBSC1 and enhanced countercurrent multiplication
    Mari Michimata
    Department of Molecular Medicine and Gene Transfer Research, Tohoku University School of Medicine, Sendai, Japan
    Kidney Int 64:933-8. 2003
    ..However, direct evidence for this association and the mechanism of rBSC1 expression are still to be elucidated...
  16. ncbi Urea transporter expression in aging kidney and brain during dehydration
    M M Trinh-Trang-Tan
    Institut National de la Santé et de la Recherche Médicale U76, Institut National de Transfusion Sanguine, 6, rue Alexandre Cabanel, F 75015 Paris, France
    Am J Physiol Regul Integr Comp Physiol 285:R1355-65. 2003
    ..In aging brain, UT-B1 abundance was increased twofold together with a fourfold increase in aquaporin-4 abundance. Dehydration did not alter the abundance of these transporters...
  17. ncbi Resistance of mTAL Na+-dependent transporters and collecting duct aquaporins to dehydration in 7-month-old rats
    Hassane Amlal
    Department of Internal Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio 45267 0585, USA
    Kidney Int 64:544-54. 2003
    ....
  18. ncbi The effects of hypoosmotic infusion on the composition of renal tissue of the Australian brush-tailed possum Trichosurus vulpecula
    J J Bedford
    Department of Physiology, University of Otago, P O Box 913, Dunedin, New Zealand
    Comp Biochem Physiol B Biochem Mol Biol 132:645-52. 2002
    ..A fall in free amino acid levels in the inner medulla appears to significantly contribute to the process of intracellular osmotic adjustment during an induced diuresis...
  19. ncbi Effects of glycyrrhizin on renal functions in association with the regulation of water channels
    Dae Gill Kang
    Professional Graduate School of Oriental Medicine, and Medicinal Resources Research Center, Wonkwang University, Iksan, Chonbuk, 570 749, Korea
    Am J Chin Med 31:403-13. 2003
    ..These results suggest that the retention of water and salt in glycyrrhizin-treated rats is, at least in part, accounted for by the increased expression of AQP 2 and 3 in the kidney, which may be causally related to the MR...
  20. ncbi Genetic restoration of aldose reductase to the collecting tubules restores maturation of the urine concentrating mechanism
    James Y Yang
    Institute of Molecular Biology and Department of Physiology, University of Hong Kong, and Division of Clinical Biochemistry, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Am J Physiol Renal Physiol 291:F186-95. 2006
    ..Together, these results suggest that aldose reductase not only plays important roles in osmoregulation and medullary cell survival but may also be essential for the full maturation of the urine concentrating mechanism...
  21. ncbi Urea and renal function in the 21st century: insights from knockout mice
    Robert A Fenton
    Water and Salt Research Center, Institute of Anatomy, Building 233 234, University of Aarhus, DK 8000 Aarhus, Denmark
    J Am Soc Nephrol 18:679-88. 2007
    ....
  22. ncbi Urea and urine concentrating ability in mice lacking AQP1 and AQP3
    Dan Zhao
    Department of Medicine, University of California, San Francisco 94143 0521, USA
    Am J Physiol Renal Physiol 291:F429-38. 2006
    ..This solute-selective response could result from the capacity of AQP3 to transport not only water but also urea. The results suggest a novel role for AQP3 in non-urea solute concentration in the urine...
  23. ncbi Vasopressin rapidly increases phosphorylation of UT-A1 urea transporter in rat IMCDs through PKA
    Chi Zhang
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Physiol Renal Physiol 282:F85-90. 2002
    ..This suggests that phosphorylation of UT-A1 may be the mechanism by which vasopressin rapidly increases urea permeability in vivo...
  24. ncbi Molecular mechanisms of urea transport
    J M Sands
    Renal Division, Department of Medicine and Department of Physiology, Emory University School of Medicine, 1639 Pierce Dr, NE, Atlanta, GA 30322, USA
    J Membr Biol 191:149-63. 2003
    ..This review will summarize the knowledge gained from studying molecular mechanisms of urea transport and from integrative studies into urea transporter protein regulation...
  25. ncbi Downregulation of renal aquaporins in response to unilateral ureteral obstruction
    Chunling Li
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 284:F1066-79. 2003
    ....
  26. ncbi The renal medullary interstitium: focus on osmotic hypertonicity
    Janusz Sadowski
    Laboratory of Renal and Body Fluid Physiology, M Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Clin Exp Pharmacol Physiol 30:119-26. 2003
    ....
  27. ncbi An optimization algorithm for a distributed-loop model of an avian urine concentrating mechanism
    Mariano Marcano
    Department of Mathematics, University of Puerto Rico, Rio Piedras, Puerto Rico 00931 3355, USA
    Bull Math Biol 68:1625-60. 2006
    ..Shorter cones were found to be more efficient than longer ones, and an optimal loop of Henle distribution was found that is consistent with experimental findings...
  28. ncbi Chronic COX-2 inhibition reduces medullary HSP70 expression and induces papillary apoptosis in dehydrated rats
    Wolfgang Neuhofer
    Department of Physiology, University of Munich, Germany
    Kidney Int 65:431-41. 2004
    ....
  29. ncbi Role of vasopressin in diabetes mellitus-induced changes in medullary transport proteins involved in urine concentration in Brattleboro rats
    Dongun Kim
    Emory Univ School of Medicine, Renal Division, WMRB Rm 338, 1639 Pierce Drive NE, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 286:F760-6. 2004
    ....
  30. ncbi Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus
    Primoz Kotnik
    The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 288:F1053-68. 2005
    ..These results identify markedly reduced expression of COX-1, COX-2, and mPGES in IM in lithium-induced NDI. Furthermore, there were major changes in the expression of COX-1, COX-2, and mPGES in rats with CDI...
  31. ncbi Lithium-induced reduction in urinary concentrating ability and urinary aquaporin 2 (AQP2) excretion in healthy volunteers
    Robert J Walker
    Department of Medical and Surgical Sciences, University of Otago, Dunedin, New Zealand
    Kidney Int 67:291-4. 2005
    ..This study examined the effects of four weeks of lithium therapy on desmopressin (dDAVP)-stimulated urinary concentrating ability in healthy volunteers...
  32. pmc Renal phenotype of UT-A urea transporter knockout mice
    Robert A Fenton
    Laboratory of Kidney Electrolyte Metabolism, National Heart, Lung and Blood Institutes, National Institutes of Health, 10 Center Drive, Building 10, Room 6N260, Bethesda, MD 20892 1603, USA
    J Am Soc Nephrol 16:1583-92. 2005
    ..These results support our conclusion that the urinary concentrating defect in UT-A1/3(-/-) mice is caused by a failure of urea transport from the IMCD lumen to the inner medullary interstitium, resulting in osmotic diuresis...
  33. ncbi A region-based mathematical model of the urine concentrating mechanism in the rat outer medulla. I. Formulation and base-case results
    Anita T Layton
    Department of Mathematics, Duke University, Durham, NC 27708 0320, USA
    Am J Physiol Renal Physiol 289:F1346-66. 2005
    ..Am J Physiol Renal Physiol 289: F1367-F1381, 2005), the impact of model assumptions, medullary anatomy, and tubular segmentation on the UCM was investigated by means of extensive parameter studies...
  34. ncbi Role of structural organization in the urine concentrating mechanism of an avian kidney
    Anita T Layton
    Department of Mathematics, Duke University, P O Box 90320, Durham, NC 27708, USA
    Math Biosci 197:211-30. 2005
    ....
  35. ncbi Three-dimensional functional reconstruction of inner medullary thin limbs of Henle's loop
    Thomas L Pannabecker
    Department of Physiology, College of Medicine, University of Arizona, Tucson, AZ 85724 5051, USA
    Am J Physiol Renal Physiol 286:F38-45. 2004
    ....
  36. ncbi Maturation of TonEBP expression in developing rat kidney
    Ki Hwan Han
    Departmrnt of Anatomy and Cell Death Disease Research Center, Catholic University Medical College, Seoul 137 701, South Korea
    Am J Physiol Renal Physiol 287:F878-85. 2004
    ..These data suggest that TonEBP contributes to the development of urine-concentrating ability...
  37. ncbi Two modes for concentrating urine in rat inner medulla
    Anita T Layton
    Department of Mathematics, University of North Carolina, Chapel Hill, NC 27759 3250, USA
    Am J Physiol Renal Physiol 287:F816-39. 2004
    ..Model studies were conducted to determine the sensitivity of these modes to parameter choices. Model results are compared with extant tissue-slice and micropuncture studies...
  38. ncbi Three-dimensional lateral and vertical relationships of inner medullary loops of Henle and collecting ducts
    Thomas L Pannabecker
    Department of Physiology, College of Medicine, University of Arizona, Tucson, AZ 85724 5051, USA
    Am J Physiol Renal Physiol 287:F767-74. 2004
    ..A similar lateral compartmentation between the ATLs and CDs is not apparent. This architectural arrangement indicates that fluid and solutes may be preferentially transported transversely between multiple inner medullary compartments...
  39. ncbi Evidence for a role of protein kinase C-alpha in urine concentration
    Lijun Yao
    Institute of Pharmacology and Toxicology, University of Tubingen, 72074 Tuebingen, Germany
    Am J Physiol Renal Physiol 287:F299-304. 2004
    ..Considering that PKC-beta I and -beta II are coexpressed with PKC-alpha in mouse medullary collecting duct, the present results indicate that conventional PKC isoenzymes cannot fully compensate for each other...
  40. ncbi Urinary aquaporin-2 levels in healthy volunteers
    Ali Al-Dameh
    Departments of Medicine and Physiology University of Otago, Dunedin, New Zealand
    Nephrology (Carlton) 8:139-41. 2003
    ..762). For specific conditions where renal water retention is stimulated via AVP, urinary AQP2 measurements provide a reproducible measurement of the renal actions of AVP...
  41. ncbi Development of water transport in the collecting duct
    Melvin Bonilla-Felix
    Department of Pediatrics, Univerity of Puerto Rico Medical Sciences, Campus, San Juan, PR 00936 5067
    Am J Physiol Renal Physiol 287:F1093-101. 2004
    ..This paper reviews the alterations in the AVP signal transduction pathway in the immature kidney...
  42. ncbi Mild dehydration, vasopressin and the kidney: animal and human studies
    N Bouby
    INSERM U 367, Paris, France
    Eur J Clin Nutr 57:S39-46. 2003
    ..However, they could also be risk factors in several renal disorders, such as chronic renal failure, diabetic nephropathy and salt-sensitive hypertension...
  43. ncbi Phenotype analysis of aquaporin-8 null mice
    Baoxue Yang
    Cardiovascular Research Institute, Univ of California, San Francisco, CA 94143 0521, USA
    Am J Physiol Cell Physiol 288:C1161-70. 2005
    ..The mild phenotype of AQP8-null mice was surprising in view of the multiple phenotype abnormalities found in mouse models of AQP1-5 deficiency...
  44. pmc Lithium-induced nephrogenic diabetes insipidus: renal effects of amiloride
    Jennifer J Bedford
    Department of Medical and Surgical Sciences, University of Otago, PO Box 913, Dunedin, New Zealand
    Clin J Am Soc Nephrol 3:1324-31. 2008
    ..Polyuria, polydipsia, and nephrogenic diabetes insipidus have been associated with use of psychotropic medications, especially lithium...
  45. ncbi Role of aquaporin-2 gene expression in hyponatremic rats with chronic vasopressin-induced antidiuresis
    T Saito
    Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Tochigi, Japan
    Kidney Int 60:1266-76. 2001
    ..Either hypervolemia or hypotonicity may diminish the post-receptor signaling of AVP in renal collecting duct cells, under the chronic AVP excess state found in SIADH...
  46. ncbi "Avian-type" renal medullary tubule organization causes immaturity of urine-concentrating ability in neonates
    W Liu
    Department of Pediatrics, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Kidney Int 60:680-93. 2001
    ..The qualitative changes in the organization of medullary tubules may be primarily responsible for the immature urine-concentrating ability in mammalian neonates...
  47. ncbi Downregulation of AQP1, -2, and -3 after ureteral obstruction is associated with a long-term urine-concentrating defect
    C Li
    Institute of Experimental Clinical Research, University of Aarhus, DK-8200 Aarhus N, Denmark
    Am J Physiol Renal Physiol 281:F163-71. 2001
    ....
  48. ncbi Limited urinary concentration and damaged tubules in rats with a syngeneic kidney graft
    M Michimata
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Medicine and Pharmaceutical Science, Sendai, Japan
    Kidney Int 60:672-9. 2001
    ..This suggests that there is a prolonged damage of renal tubules by ischemia or denervation of the donor kidney, both of which are inevitable in the transplantation procedure...
  49. ncbi Reduced expression of Na-K-2Cl cotransporter in medullary TAL in vitamin D-induced hypercalcemia in rats
    Weidong Wang
    Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 282:F34-44. 2002
    ....
  50. ncbi Aquaporin-1 is not expressed in descending thin limbs of short-loop nephrons
    Xiao Yue Zhai
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, Arhus C, Denmark
    J Am Soc Nephrol 18:2937-44. 2007
    ..Likewise, the roles of aquaporin-1 and UT-A2 in the countercurrent multiplier and water conversation may need to be readdressed...
  51. ncbi Quantitative analysis of functional reconstructions reveals lateral and axial zonation in the renal inner medulla
    Thomas L Pannabecker
    Univ of Arizona Health Sciences Center, Dept of Physiology, AHSC 4130, 1501 N Campbell Ave, Tucson, AZ 85724 5051, USA
    Am J Physiol Renal Physiol 294:F1306-14. 2008
    ..5 mm. These transverse segments expand surface area for probable NaCl efflux around loop bends from approximately 40% to approximately 140% of CD surface area in the final 100 microm of the papilla...
  52. ncbi Abnormal water metabolism in mice lacking the type 1A receptor for ANG II
    M I Oliverio
    Department of Medicine, Duke University, and Veterans Affairs Medical Centers, Durham, NC 27710, USA
    Am J Physiol Renal Physiol 278:F75-82. 2000
    ..These studies demonstrate a critical role for the AT(1A) receptor in maintaining inner medullary structures in the kidney and in regulating renal water excretion...
  53. ncbi The effects of water deprivation and salt load on water conservation efficiency in two Indian desert gerbils
    T O Sasidharan
    Division of Animal Studies, Central Arid Zone Research Institute, Jodhpur, India
    J Comp Physiol B 160:413-22. 1990
    ..indica = 1628 mM; M. hurrianae = 1372 mM). The results indicate that T. indica may be better adapted to produce more concentrated urine than M. hurrianae...
  54. ncbi Aquaporin-2 downregulation in kidney medulla of aging rats is posttranscriptional and is abolished by water deprivation
    S Combet
    CEA, Institut de Biologie et Technologies de Saclay and CNRS URA 2096, Orsay, France
    Am J Physiol Renal Physiol 294:F1408-14. 2008
    ..In the IMCD, no change in AQP2 mRNA was detected with aging but AQP2 protein expression was markedly lower in 30-mo-old animals. In conclusion, there is a posttranscriptional downregulation of AQP2 with aging, which is abolished by WD...
  55. ncbi PKD1 haploinsufficiency causes a syndrome of inappropriate antidiuresis in mice
    Ali K Ahrabi
    Division of Nephrology, UCL Medical School, Universite Catholique de Louvain, 10 Avenue Hippocrate, B 1200 Brussels, Belgium
    J Am Soc Nephrol 18:1740-53. 2007
    ..These data give new insights in the potential roles of polycystin-1 in the AVP and Ca(2+) signaling and the trafficking of AQP2 in the CD...
  56. ncbi Renal concentrating defect in mice lacking group IV cytosolic phospholipase A(2)
    P Downey
    Medical and Anesthesia Services, Massachusetts General Hospital, Charlestown, 02129, USA
    Am J Physiol Renal Physiol 280:F607-18. 2001
    ..Thus mice lacking cPLA(2) develop an age-related defect in renal concentration that may be related to abnormal trafficking and/or folding of AQP1 in the proximal tubule, implicating cPLA(2) in these processes...
  57. pmc Hypernatremia in the aging: causes, manifestations, and outcome
    S I Borra
    Department of Medicine, Kingsbrook Jewish Medical Center, Brooklyn, New York, USA
    J Natl Med Assoc 87:220-4. 1995
    ..Other electrolyte disorders that impair the kidney concentrating ability frequently are observed...
  58. ncbi Aquaporin 2 and apical calcium-sensing receptor: new players in polyuric disorders associated with hypercalciuria
    G Procino
    Department of General and Environmental Physiology and Center of Excellence in Comparative Genomics, University of Bari, Bari, Italy
    Semin Nephrol 28:297-305. 2008
    ..Understanding the molecular basis of alteration of kidney concentrating ability found in hypercalciuria will help for devising strategies for reducing the risk of nephrocalcinosis, ..
  59. ncbi Vasopressin, copeptin, and renal concentrating capacity in patients with autosomal dominant polycystic kidney disease without renal impairment
    Debbie Zittema
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin J Am Soc Nephrol 7:906-13. 2012
    ..It is clinically acknowledged that ADPKD patients have impaired urine concentrating capacity, but the mechanism behind this observation is unknown...
  60. ncbi Urinary concentration defect and limited expression of sodium cotransporter, rBSC1, in a rat model of chronic renal failure
    Mari Michimata
    Department of Clinical Pharmacology, Tohoku University, Graduate School of Pharmaceutical Science, Sendai, Japan
    Nephron Physiol 93:p34-41. 2003
    ..Since urinary concentration defect and hypertrophy of residual nephrons are major manifestations of chronic renal failure (CRF), we investigated the rBSC1 signals for RNA and protein in a rat model of CRF...
  61. ncbi Developmental expression of CLC-K1 in the postnatal rat kidney
    K Kobayashi
    Department of Pediatrics, Tokyo Medical and Dental University, School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Histochem Cell Biol 116:49-56. 2001
    ..These results suggest that CLC-K1 expression is one of the major determinants of the urine-concentrating capacity of the developing rat kidney...
  62. ncbi [Osmolarity]
    Akitoshi Ando
    Section of Kidney and Metabolism, Tokyo Rosai Hospital
    Nihon Rinsho 62:271-4. 2004
  63. pmc Pax transactivation-domain interacting protein is required for urine concentration and osmotolerance in collecting duct epithelia
    Doyeob Kim
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
    J Am Soc Nephrol 18:1458-65. 2007
    ..The data suggest an essential role for ptip in regulating urine concentration and in controlling survival of collecting duct epithelial cells in high osmolality...
  64. ncbi An efficient numerical method for distributed-loop models of the urine concentrating mechanism
    Anita T Layton
    Department of Mathematics, University of North Carolina, Phillips Hall, Campus Box 3250, Chapel Hill, NC 27599, USA
    Math Biosci 181:111-32. 2003
    ..The combination of the SLSI method and the Newton-type solver generates stable and accurate solutions with substantially reduced computation times, when compared to previously applied dynamic methods...
  65. ncbi Is there a role for PGE2 in urinary concentration?
    Emma T B Olesen
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    J Am Soc Nephrol 24:169-78. 2013
    ..PGE2 has an intricate role in urinary concentration, and we now suggest how targeting specific prostanoid receptor signaling pathways could be exploited for the treatment of disorders in water balance...
  66. ncbi Altered expression of renal AQPs and Na(+) transporters in rats with lithium-induced NDI
    T H Kwon
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, United Kingdom
    Am J Physiol Renal Physiol 279:F552-64. 2000
    ..In contrast, the increased or unchanged expression of NHE3, BSC-1, Na-K-ATPase, and TSC indicates that these Na(+) transporters do not participate in the development of Li-induced polyuria...
  67. ncbi Vasopressin secretion in response to osmotic stimulation and effects of desmopressin on urinary concentrating capacity in dogs with pyometra
    Reidun Heiene
    Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, PO Box 8146 Dep, 0033 Oslo, Norway
    Am J Vet Res 65:404-8. 2004
    ..To determine vasopressin (VP) secretory capacity during osmotic stimulation and the response to desmopressin treatment in dogs with pyometra and control dogs...
  68. pmc Axial compartmentation of descending and ascending thin limbs of Henle's loops
    Kristen Y Westrick
    Department of Physiology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Am J Physiol Renal Physiol 304:F308-16. 2013
    ..We hypothesize that DTLs and ATLs enter and exit CD clusters in an orchestrated fashion that is important for generation of the corticopapillary solute gradient by minimizing NaCl and urea loss...
  69. ncbi Refinement of the urine concentration test in rats
    Lisa J Kulick
    Covance Laboratories Inc, 3301 Kinsman Boulevard, Madison, Wisconsin 53704 2523, USA
    Contemp Top Lab Anim Sci 44:46-9. 2005
    ..Based on this study, it was concluded that the urine concentration test can be refined such that rats are not deprived of water for more than 16 h without jeopardizing test results...
  70. pmc Vasopressin increases expression of UT-A1, UT-A3, and ER chaperone GRP78 in the renal medulla of mice with a urinary concentrating defect
    Qi Cai
    Dept of Physiology, College of Medicine, Univ of Arizona, Tucson, AZ 85724 5218, USA
    Am J Physiol Renal Physiol 299:F712-9. 2010
    ..These findings strongly support an important role of vasopressin in the activation of an ER stress response in renal collecting duct cells, in addition to its role in activating an increase in UT-A1 and UT-A3 abundance...
  71. ncbi Angiotensin-converting enzyme inhibition in piglets induces persistent renal abnormalities
    G Guron
    Department of Physiology, Institute of Physiology and Pharmacology, Goteborg University, Sweden
    Clin Exp Pharmacol Physiol 25:88-91. 1998
    ..6. The present study demonstrates that an intact RAS is required for normal renal development in the pig, similar to previous observations made in rodents...
  72. pmc Abnormal function of the vasopressin-cyclic-AMP-aquaporin2 axis during urine concentrating and diluting in patients with reduced renal function. A case control study
    Erling B Pedersen
    Department of Medical Research, Holstebro Hospital, Laegaardvej 12, 7500 Holstebro, Denmark
    BMC Nephrol 11:26. 2010
    ..We wanted to test the hypothesis that these phenomena could be attributed to an abnormal function of the principal cells in the distal part of the nephron...
  73. ncbi Kidney modeling and systems physiology
    S Randall Thomas
    IBISC CNRS FRE 3190 and University of Evry, Tour Evry 2, 91000 Evry, France
    Wiley Interdiscip Rev Syst Biol Med 1:172-90. 2009
    ....
  74. pmc Osmoregulatory defect in adult mice associated with deficient prenatal expression of six2
    S Jack Somponpun
    Department of Anatomy, Biochemistry, and Physiology, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA
    Am J Physiol Regul Integr Comp Physiol 301:R682-9. 2011
    ....
  75. ncbi Hypertonicity and TonEBP promote development of the renal concentrating system
    Dietmar Kültz
    Physiological Genomics Group, Dept of Animal Science, University of California Davis, Meyer Hall, 1 Shields Avenue, Davis, CA 95616, USA
    Am J Physiol Renal Physiol 287:F876-7. 2004
  76. pmc A mathematical model of the urine concentrating mechanism in the rat renal medulla. II. Functional implications of three-dimensional architecture
    Anita T Layton
    Department of Mathematics, Duke University, Durham, NC 27708 0320, USA
    Am J Physiol Renal Physiol 300:F372-84. 2011
    ..Model calculations predict that these aspects of tubular segmentation and heterogeneity promote effective urine concentrating functions...
  77. ncbi Challenges and intriguing problems in comparative renal physiology
    William H Dantzler
    Department of Physiology, College of Medicine, University of Arizona, Tucson, AZ 85724 5051, USA
    J Exp Biol 208:587-94. 2005
    ..These are some examples of intriguing possibilities for comparative studies of renal physiology...
  78. ncbi Effect of primary polydipsia on aquaporin and sodium transporter abundance
    Melissa A Cadnapaphornchai
    Department of Medicine, University of Colorado School of Medicine, Denver 80262, USA
    Am J Physiol Renal Physiol 285:F965-71. 2003
    ..We conclude that the impaired urinary concentrating ability associated with primary POLY in rats is due to impaired osmotic equilibration in the collecting duct that is mediated primarily by decreased AQP-2 protein abundance...
  79. ncbi Helicobacter pylori infection may increase renal resistive index
    Baris Afsar
    Med Hypotheses 69:956-7. 2007
  80. ncbi Impaired urine concentration and absence of tissue ACE: involvement of medullary transport proteins
    Janet D Klein
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Physiol Renal Physiol 283:F517-24. 2002
    ..We conclude that the urine-concentrating defect in ACE.2 mice is associated with, and may result from, downregulation of some or all of these key urea, salt, and water transport proteins...
  81. ncbi [Progress in renal physiology]
    Katsumasa Kahara
    Nihon Jinzo Gakkai Shi . 2007
  82. ncbi A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 null mutant mice develop renal lesions mimicking obstructive nephropathy
    Hitoshi Yokoyama
    Division of Blood Purification, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan
    Nephrol Dial Transplant 17:39-41. 2002
    ..We studied the biological role of ADAMTS-1 in the kidney...
  83. pmc Nephrogenic diabetes insipidus in mice caused by deleting COOH-terminal tail of aquaporin-2
    Peijun P Shi
    Department of 1Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Renal Physiol 292:F1334-44. 2007
    ..Thus we have generated a mouse model of NDI that may be useful in studying the physiology and potential therapy of this disease...
  84. ncbi Urine concentrating defect in prostaglandin EP1-deficient mice
    Chris R J Kennedy
    Department of Medicine, Ottawa Hospital, Ontario, Canada
    Am J Physiol Renal Physiol 292:F868-75. 2007
    ..These data suggest that PGE(2) modulates urine concentration by acting at EP(1) receptors, not in the collecting duct, but within the hypothalamus to promote AVP synthesis in response to acute WD...
  85. ncbi [Easy approach to clinical study on water-electrolyte imbalance]
    Shunya Uchida
    Nihon Naika Gakkai Zasshi 95:809-13. 2006
  86. ncbi Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function
    D P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Renal Physiol 281:F887-99. 2001
    ..We hypothesize that severe ischemic injury results in a permanent alteration of renal capillary density, contributing to a urinary concentrating defect and the predisposition toward the development of renal fibrosis...
  87. ncbi Quantitative imaging of basic functions in renal (patho)physiology
    Jung Julie Kang
    Department of Physiology, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California 90033, USA
    Am J Physiol Renal Physiol 291:F495-502. 2006
    ..These innovative technologies provide the most complex, immediate, and dynamic portrayal of renal function, clearly depicting the components and mechanisms involved in normal physiology and pathophysiology...
  88. ncbi [Management of water electrolyte imbalance in aged patients]
    Tomohiro Katsuya
    Nihon Naika Gakkai Zasshi 92:799-805. 2003
  89. ncbi A region-based model framework for the rat urine concentrating mechanism
    Anita T Layton
    Department of Mathematics, University of North Carolina, Phillips Hall, Campus Box 3250, Chapel Hill, North Carolina 27599 3250, USA
    Bull Math Biol 65:859-901. 2003
    ..We present representative solutions and show that the method generates approximations that are second-order accurate in space and that exhibit mass conservation...
  90. ncbi Genetic manipulation of the renin-angiotensin system
    T N Doan
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Curr Opin Nephrol Hypertens 10:483-91. 2001
    ..This suggests an unexplored role for angiotensin-converting enzyme in conception. Future studies with these and other genetically engineered mice lines will reveal novel physiological effects of angiotensin II...
  91. ncbi [Structure and function of intermediate tubules]
    Yoshiaki Kondo
    Department of Medical Informatics, Tohoku University Graduate School of Medicine
    Nihon Rinsho 64:88-92. 2006
  92. ncbi A novel small-molecule thienoquinolin urea transporter inhibitor acts as a potential diuretic
    Fei Li
    Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China
    Kidney Int 83:1076-86. 2013
    ..PU-14 may establish 'chemical knockout' animal models to study the physiological functions of UTs...
  93. ncbi An inverse algorithm for a mathematical model of an avian urine concentrating mechanism
    M Marcano-Velázquez
    Department of Mathematics, University of Puerto Rico, P O Box 23355, Rio Piedras, Puerto Rico 00931 3355, USA
    Bull Math Biol 65:665-91. 2003
    ..When maximum-efficiency parameter values were computed as medullary length varied over the physiologic range, the PBE was found to make up 88% of a short medullary cone but only 8% of a long medullary cone...
  94. ncbi Renal phenotype of low kallikrein rats
    P Madeddu
    National Laboratory of the National Institute of Biostructures and Biosystems, Osilo, Italy
    Kidney Int 59:2233-42. 2001
    ..Identification of a cause--effect relationship between low kallikrein and intermediate phenotypes has been hampered by the lack of adequate animal models...
  95. pmc Effects of pH and medullary blood flow on oxygen transport and sodium reabsorption in the rat outer medulla
    Jing Chen
    Department of Mathematics, Duke University, Durham, North Carolina, USA
    Am J Physiol Renal Physiol 298:F1369-83. 2010
    ..That is, at a sufficiently high medullary O(2) supply, O(2) demand in the outer medulla does not adjust precisely to changes in O(2) delivery...
  96. ncbi [History of nephrology in the past 100 years: Kidney function tests]
    Yoshimasa Orita
    Nihon Naika Gakkai Zasshi 91:1381-4. 2002
  97. ncbi Pericyte regulation of renal medullary blood flow
    T L Pallone
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD 21201 1595, USA
    Exp Nephrol 9:165-70. 2001
    ..Known vasoconstrictors of DVR include angiotensin II, endothelins, norepinephrine, acetylcholine, and adenosine. Vasodilators include prostaglandin E2, adenosine, acetylcholine, bradykinin, and nitric oxide...
  98. ncbi The consequences for renal function of widening of the interstitium and changes in the tubular epithelium of the renal cortex and outer medulla in various renal diseases
    S Mackensen-Haen
    Institute of Pathology, University of Tubingen, Germany
    Clin Nephrol 37:70-7. 1992
    ..5) Compensatory hypertrophy of individual nephrons, as proposed by Bricker's hypothesis, was found only where more than 90% of the glomeruli were hyalinized.(ABSTRACT TRUNCATED AT 250 WORDS)..
  99. ncbi Interaction of modeling and experimental approaches to understanding renal salt and water balance
    J A Schafer
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 35294 0005, USA
    Ann Biomed Eng 28:1002-9. 2000
    ..However, even greater will be the challenge to anticipate, and hopefully predict, the subtle ways in which the organism typically adapts to aberrations in these normal functional parameters, but sometimes does not...
  100. ncbi A missense mutation in the arginine-vasopressin neurophysin-II gene causes autosomal dominant neurohypophyseal diabetes insipidus in a Chinese family
    Dan Ye
    Department of Endocrinology and Metabolism, the First Affiliated Hospital of Medical School of Zhejiang University, Zhejiang, China
    Clin Endocrinol (Oxf) 78:920-5. 2013
    ..The mutations lead to aberrant preprohormone processing and progressive destruction of AVP-secreting cells, which gradually manifests a progressive polyuria and polydipsia during early childhood, and a disorder of water homeostasis...
  101. ncbi Urine-concentrating defects exacerbate with age in male offspring with a low-nephron endowment
    Reetu R Singh
    School of Biomedical Sciences, University of Queensland, St Lucia, 4067 QLD, Australia
    Am J Physiol Renal Physiol 301:F1168-76. 2011
    ..Renal insufficiency due to a low-nephron endowment increases the risk of hypertension and chronic renal disease and may incur greater vulnerability to physiological challenges such as water deprivation as observed in the uni-x animals...

Research Grants20

  1. MATHEMATICAL MODELS OF RENAL DYNAMICS
    HAROLD LAYTON; Fiscal Year: 2009
    ..abstract_text> ..
  2. Regulation of Urea Transport by Adrenal Steroids
    JEFF SANDS; Fiscal Year: 2005
    ..We also found that UT-A1 protein abundance is decreased during in vivo conditions associated with increased glucocorticoids. ..
  3. RENAL TRANSPORT OF NONELECTROLYTES, SALT AND WATER
    James Schafer; Fiscal Year: 2002
    ..These observations will provide important information regarding the physiological or pathophysiological circumstances under which AVP would contribute to salt retention. ..
  4. SHIGA LIKE TOXIN AND RENAL CELL DYSFUNCTION
    Donald Kohan; Fiscal Year: 2001
    ..These studies provide essential information on how and why HGEN are damaged in HUS. ..
  5. Renal Inner Medulla: Integrated Structure and Function
    WILLIAM DANTZLER; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  6. Reactive Oxygen Species American Society of Nephrology Fall 2007
    THOMAS PALLONE; Fiscal Year: 2007
    ..Attendance of young scientists insures that the information will be translated into future studies that elucidate the role of ROS in kidney diseases and treatment thereof. [unreadable] [unreadable] [unreadable]..
  7. Collecting duct endothelin-1 and hypertension
    Donald Kohan; Fiscal Year: 2009
    ..Such information is important in understanding intrarenal mechanisms responsible for hypertension and salt and water retention. ..
  8. Mathematical Model of Vascular and Tubular Transport in the Rat Outer Medulla
    AURELIE EDWARDS; Fiscal Year: 2008
    ..We will simulate the effects of renal perfusion pressure-induced elevations in medullary CO concentrations on mTAL sodium reabsorption, so as to gain some insight into the mechanisms underlying pressure natriuresis. ..
  9. Modulators of Nitric Oxide Synthase Activity in Sickle Cell Disease
    Mary E Fabry; Fiscal Year: 2010
    ..These observations may be applicable to patient interventions. ..
  10. Physiologic role of collecting duct ciiliary proteins
    Donald Kohan; Fiscal Year: 2007
    ..Most importantly, this work may shed light on novel mechanisms involved in control of blood pressure and development of hypertension. [unreadable] [unreadable] [unreadable]..
  11. Mechanisms of renal cell adaptation to hypertonicity
    DIETMAR KUELTZ; Fiscal Year: 2006
    ..Aim 4: By studying the proteins that are targeted by GADD45 proteins during hypertonic stress in renal inner medullary cells. ..
  12. Ninth International Conference on Endothelin (ET-9)
    Donald Kohan; Fiscal Year: 2005
    ..abstract_text> ..
  13. EFFECT OF SHIGATOXIN-1 ON BRAIN ENDOTHELIAL CELLS
    Donald Kohan; Fiscal Year: 2004
    ....
  14. Genetics of Angiotensinogen-Mediated Hypertension: Stage, Background & Gender
    Donald E Kohan; Fiscal Year: 2010
    ..Our goal is to advance the specificity of clinical management and treatment of EH. ..
  15. Calcium Signaling in Vasa Recta Endothelium
    THOMAS PALLONE; Fiscal Year: 2004
    ..We will test whether DVR contractions to norepinephrine, Angll and KCI are increased, measure NO production and assess effects of OH on endothelial and pericyte Ca2+ signaling. ..
  16. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2003
    ....
  17. VASOMOTOR CONTROL OF DESCENDING VASA RECTA
    THOMAS PALLONE; Fiscal Year: 2003
    ....
  18. MICROVASCULAR TRANSPORT IN THE RENAL MEDULLA
    THOMAS PALLONE; Fiscal Year: 2002
    ..Exchange of albumin and middle molecular weight solutes will also be simulated. ..
  19. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2010
    ..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
  20. P2U(P2Y2)-PURINOCEPTOR AND WATER TRANSPORT IN RAT KIDNEY
    BELLAMKONDA KISHORE; Fiscal Year: 2004
    ..Successful completion of these studies will lead to significant insights into the AVP-independent mechanisms of regulation of collecting duct water permeability. ..