urinary tract physiology

Summary

Summary: Functions and activities of the urinary tract as a whole or of any of its parts.

Top Publications

  1. ncbi Anatomy and physiology of urinary elimination. Part 1
    Glynis Collis Pellatt
    Faculty of Health and Social Science, University of Bedfordshire
    Br J Nurs 16:406-10. 2007
  2. ncbi A role for the P2X receptor in urinary tract physiology and in the pathophysiology of urinary dysfunction
    David E Rapp
    Section of Urology, Department of Surgery, University of Chicago Pritzker School of Medicine, 5841 S Maryland Avenue, MC 6038, Chicago, IL 60637, USA
    Eur Urol 48:303-8. 2005
  3. ncbi [The practice guideline 'Lower urinary-tract symptoms in middle-aged and elderly men' (second revision) from the Dutch College of General Practitioners; a response from the perspective of urology]
    M P M Q van Gils
    Universitair Medisch Centrum St Radboud, afd Urologie, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 149:1551-2. 2005
  4. ncbi [The practice guideline 'Lower urinary-tract symptoms in middle-aged and elderly men' (second revision) from the Dutch College of General Practitioners; a response from the perspective of general practice]
    S Thomas
    Erasmus MC, afd Huisartsgeneeskunde, Dr Molewaterplein 50, 3015 GE Rotterdam
    Ned Tijdschr Geneeskd 149:1549-50. 2005
  5. ncbi Anatomic and physiologic considerations in ureteroscopy
    Margarett Shnorhavorian
    Section of Urology, Department of Surgery, Yale University School of Medicine, New Haven, CT 05610, USA
    Urol Clin North Am 31:15-20. 2004
  6. pmc Continuous uroflow cystometry in the urethane-anesthetized mouse
    Phillip P Smith
    Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA
    Neurourol Urodyn 29:1344-9. 2010
  7. ncbi Functional foods and the urinary tract
    Scott A Brown
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Vet Clin North Am Small Anim Pract 34:173-85, vi-vii. 2004
  8. ncbi [Role of estrogens in lower urinary tract physiology and physiopathology]
    X Game
    Département d urologie, CHU Rangueil, TSA 50032, 31059 Toulouse, France
    Prog Urol 23:502-10. 2013
  9. ncbi Physiology of the lower urinary tract
    Mary P Fitzgerald
    Division of Female Pelvic Medicine and Reconstructive Pelvic Surgery, Loyola University Medical Center, Maywood, IL 60153, USA
    Clin Obstet Gynecol 47:18-27. 2004
  10. ncbi Early proactive management improves upper urinary tract function and reduces the need for surgery in patients with myelomeningocele
    Thomas M Kessler
    Neuro urology unit, Department of Neurology, University Hospital Innsbruck, Innsbruck, Austria
    Neurourol Urodyn 25:758-62. 2006

Scientific Experts

Detail Information

Publications69

  1. ncbi Anatomy and physiology of urinary elimination. Part 1
    Glynis Collis Pellatt
    Faculty of Health and Social Science, University of Bedfordshire
    Br J Nurs 16:406-10. 2007
    ..The importance of prevention of cross infection for nurses and patients is highlighted throughout the article...
  2. ncbi A role for the P2X receptor in urinary tract physiology and in the pathophysiology of urinary dysfunction
    David E Rapp
    Section of Urology, Department of Surgery, University of Chicago Pritzker School of Medicine, 5841 S Maryland Avenue, MC 6038, Chicago, IL 60637, USA
    Eur Urol 48:303-8. 2005
    ..We provide a historical perspective of the P2X receptor class in bladder physiology and the pathophysiology of urinary dysfunction...
  3. ncbi [The practice guideline 'Lower urinary-tract symptoms in middle-aged and elderly men' (second revision) from the Dutch College of General Practitioners; a response from the perspective of urology]
    M P M Q van Gils
    Universitair Medisch Centrum St Radboud, afd Urologie, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 149:1551-2. 2005
    ..It is important to stress that lower urinary-tract symptoms do not increase the patient's risk of prostate cancer. Screening for prostate cancer by the routine measurement of serum prostate-specific antigen is therefore not indicated...
  4. ncbi [The practice guideline 'Lower urinary-tract symptoms in middle-aged and elderly men' (second revision) from the Dutch College of General Practitioners; a response from the perspective of general practice]
    S Thomas
    Erasmus MC, afd Huisartsgeneeskunde, Dr Molewaterplein 50, 3015 GE Rotterdam
    Ned Tijdschr Geneeskd 149:1549-50. 2005
    ..The Dutch general practitioners' guideline for micturition problems in elderly men addresses this paradigm change in a thorough and easily understandable way...
  5. ncbi Anatomic and physiologic considerations in ureteroscopy
    Margarett Shnorhavorian
    Section of Urology, Department of Surgery, Yale University School of Medicine, New Haven, CT 05610, USA
    Urol Clin North Am 31:15-20. 2004
    ..An appreciation of the impact of ureteroscopy on normal anatomy and physiology can prevent complications and promote improved therapeutic outcomes...
  6. pmc Continuous uroflow cystometry in the urethane-anesthetized mouse
    Phillip P Smith
    Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA
    Neurourol Urodyn 29:1344-9. 2010
    In vivo animal cystometry represents an accepted methodology for the study of lower urinary tract physiology. A particular advantage of the mouse model is the availability of genetically modified strains, offering the possibility of ..
  7. ncbi Functional foods and the urinary tract
    Scott A Brown
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Vet Clin North Am Small Anim Pract 34:173-85, vi-vii. 2004
    ....
  8. ncbi [Role of estrogens in lower urinary tract physiology and physiopathology]
    X Game
    Département d urologie, CHU Rangueil, TSA 50032, 31059 Toulouse, France
    Prog Urol 23:502-10. 2013
    ..The aim was to review the literature on estrogens and lower urinary tract...
  9. ncbi Physiology of the lower urinary tract
    Mary P Fitzgerald
    Division of Female Pelvic Medicine and Reconstructive Pelvic Surgery, Loyola University Medical Center, Maywood, IL 60153, USA
    Clin Obstet Gynecol 47:18-27. 2004
  10. ncbi Early proactive management improves upper urinary tract function and reduces the need for surgery in patients with myelomeningocele
    Thomas M Kessler
    Neuro urology unit, Department of Neurology, University Hospital Innsbruck, Innsbruck, Austria
    Neurourol Urodyn 25:758-62. 2006
    ..To investigate whether upper urinary tract function and the need for surgery in patients with myelomeningocele depends on the timing of initiating neurourological management...
  11. pmc Interaction between interstitial cells and smooth muscles in the lower urinary tract and penis
    Hikaru Hashitani
    Department of Regulatory Cell Physiology and Nephrourology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Physiol 576:707-14. 2006
    ..However, overall contractility of urethral smooth muscles does not necessarily rely on pacemaking of ICs, and thus some population of smooth muscles may also have their own excitability...
  12. pmc Organization and function of ICC in the urinary tract
    N G McHale
    Smooth Muscle Research Centre, Dundalk Institute of Technology, Dundalk, Co Louth, Ireland
    J Physiol 576:689-94. 2006
    ..However, their role in the modulation of urethral tone has yet to be fully elucidated...
  13. ncbi Cerebral activation during withholding urine with full bladder in healthy men using 99mTc-HMPAO SPECT
    Yafu Yin
    Department of Radiology, Asahikawa Medical College, Asahikawa, Japan
    J Nucl Med 47:1093-8. 2006
    ..The aim of this study was to identify the brain areas that control urinary continence in healthy men by 99mTc-hexamethylpropyleneamine oxime (99mTc-HMPAO) SPECT...
  14. ncbi Expression of vascular endothelial growth factor in the lower urinary tract in rats after castration and estrogen administration
    Eliana V M Zucchi
    Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Menopause 13:500-5. 2006
    ....
  15. ncbi Symposium report on urothelial dysfunction: pathophysiology and novel therapies
    A Kanai
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Urol 175:1624-9. 2006
    ....
  16. ncbi FGF-10 and its receptor exhibit bidirectional paracrine targeting to urothelial and smooth muscle cells in the lower urinary tract
    Dianzhong Zhang
    Program in Human Urothelial Biology, Children s Hospital and Regional Medical Center, 4800 NE Sand Point Way, Mail Stop A8938, Seattle, WA 98105, USA
    Am J Physiol Renal Physiol 291:F481-94. 2006
    ....
  17. ncbi [Management of endometriosis of the urinary tract]
    P Collinet
    clinique de gynécologie, obstétrique et néonatalogie, Hopital Jeanne de Flandre, CHRU de Lille, 2, Avenue Oscar Lambret, 59037 Lille Cedex, France
    Gynecol Obstet Fertil 34:347-52. 2006
    ..Surgical treatment of bladder and/or ureteral endometriosis requires informed consent of patients and multidisciplinary management...
  18. ncbi Clinically relevant physiology of the neonate
    Sophie A Grundy
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California at Davis, Room 1114 Tupper Hall, 1 Shields Avenue, Davis, CA 95616, USA
    Vet Clin North Am Small Anim Pract 36:443-59, v. 2006
    ..In this article, the most striking physiologic differences between neonatal and adult body systems are discussed with respect to the resulting clinical implications...
  19. pmc Going in circles: conserved mechanisms control radial patterning in the urinary and digestive tracts
    Cathy Mendelsohn
    Department of Urology, Columbia University, New York, New York 10032, USA
    J Clin Invest 116:635-7. 2006
    ..Deletion of Tbx18 resulted in defective urothelial differentiation at the level of the ureter, suggesting that Tbx18 acts via mesenchyme as an important regulator of A-P patterning in the urinary tract...
  20. ncbi Mechanisms of Disease: specialized interstitial cells of the urinary tract--an assessment of current knowledge
    Alison F Brading
    Pharmacology Department of Oxford University, Oxford, UK
    Nat Clin Pract Urol 2:546-54. 2005
    ..Differences in the numbers of ICC are seen in smooth muscle specimens obtained from patients with various pathologies; in particular, bladder overactivity is associated with increased numbers of these cells...
  21. ncbi Minimally-invasive electrical stimulation of the pudendal nerve: a pre-clinical study for neural control of the lower urinary tract
    Paul B Yoo
    Neural Prosthesis Research Laboratory, Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708 0281, USA
    Neurourol Urodyn 26:562-9. 2007
    ..This pre-clinical study was undertaken to test the hypothesis that robust bladder contractions can be generated with a minimally-invasive needle electrode...
  22. ncbi Pacemaker activity in the upper urinary tract
    Robert M Weiss
    Section of Urology, Yale University School of Medicine, New Haven, Conneticut 06520 8041, USA
    J Smooth Muscle Res 42:103-15. 2006
    ..Capsaicin-sensitive sensory afferents and the endogenous release of tachykinins and prostaglandins are involved in the maintenance of normal ureteral peristalsis...
  23. pmc Bladder afferent signaling: recent findings
    Anthony Kanai
    Department of Medicine and Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Urol 183:1288-95. 2010
    Much current research on lower urinary tract physiology focuses on afferent mechanisms. The main goals are to define and control the signaling pathways by which afferent information is generated and conveyed to the central nervous system...
  24. ncbi Examination of the urinary tract in the horse
    M Eilidh Wilson
    Department of Large Animal Clinical Sciences, D 202 Veterinary Medical Center, Michigan State University, East Lansing, MI 48824 1314, USA
    Vet Clin North Am Equine Pract 23:563-75, v. 2007
    ..Further, clinical signs that may seem to be directly related to the urinary tract may be the result of other systemic diseases. Thus, before embarking on diagnostics, it is important to obtain a thorough history and physical examination...
  25. ncbi Essentials of equine renal and urinary tract physiology
    Ramiro E Toribio
    College of Veterinary Medicine, The Ohio State University, 601 Vernon Tharp Street, Columbus, OH 43210, USA
    Vet Clin North Am Equine Pract 23:533-61, v. 2007
    ..Endogenous and exogenous compounds (eg, drugs, toxins, hemoglobin) alone or in combination with inappropriate renal blood flow can promote or exacerbate renal disease...
  26. ncbi [Analysis of electrical activities of the junction region of the ureter with bladder and surrounding zones in rats]
    K V Kazarian
    Ross Fiziol Zh Im I M Sechenova 93:799-805. 2007
    ..In area of ureter connection with bladder, slow-wave activity was revealed. In bladder bordering ureter zone, rapid spike activity was found that was fully correlated with the genesis of upper located fluctuation processes...
  27. ncbi [Forms of urinary diversion--methods and imaging findings]
    S Obenauer
    Abteilung für diagnostische Radiologie, Georg August Universitat Gottingen
    Rofo 179:1025-34. 2007
    ..CT urography and MR urography are becoming increasingly important as further imaging tools for controlling urinary diversions...
  28. ncbi Transabdominal ultrasound in the assessment of postvoid residual urine volume in patients after hysterectomy
    Tripop Lertbunnaphong
    Department of Obstetrics and Gynecology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    J Med Assoc Thai 89:S152-7. 2006
    ..To evaluate the correlation between assessment of postvoid residual urine by transabdominal ultrasound and catheterization in patients after radical or transvaginal hysterectomy...
  29. pmc The biomechanical properties of E. coli pili for urinary tract attachment reflect the host environment
    Magnus Andersson
    Department of Physics, Umea University, Umea, Sweden
    Biophys J 93:3008-14. 2007
    ..Our findings highlight functions that are believed to be of importance for the bacterial ability to sustain a basic antimicrobial mechanism of the host and for bacterial colonization...
  30. ncbi [Long-term results of lower urinary tract symptoms and urinary flow rate after transurethral resection of the prostate]
    Yoshinori Tanaka
    Urology Service, Esashi Hospital
    Hinyokika Kiyo 53:369-73. 2007
    ....
  31. ncbi Effect of lumbar-epidural administration of tramadol on lower urinary tract function
    S K Singh
    Department of Urology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Neurourol Urodyn 27:65-70. 2008
    ..In animal studies tramadol has been found not to affect voiding function. We evaluated urodynamic effects of epidural tramadol in humans...
  32. ncbi [Treatment of neurogenic detrusor hyperactivity: enterocystoplasty]
    X Game
    Service d Urologie, centre hospitalo universitaire de Toulouse, France
    Prog Urol 17:584-96. 2007
    ..The authors present the technical details of bladder augmentation by enterocystoplasty or by alternative techniques and their medium- and long-term results, and define the postoperative surveillance of this type of surgery...
  33. ncbi [Anatomy and physiology of the lower urinary tract]
    B Parratte
    Centre hospitalo universitaire de Bezançon, France
    Prog Urol 17:331-5. 2007
    ..Due to the presence of both smooth and striated muscle cells in structures of the lower urinary tract, nerve pathways and nerve centres belong to both the somatic and autonomic nervous systems...
  34. ncbi Modeling physiology of the urinary tract
    Thomas A Spirka
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio 44118, USA
    J Endourol 21:294-299. 2007
    ....
  35. ncbi Interaction of filling related sensation between anorectum and lower urinary tract and its impact on the sequence of their evacuation. A study in healthy volunteers
    Stefan De Wachter
    Department of Urology, Faculty of Medicine, University Hospital Antwerpen, Antwerpen, Belgium
    Neurourol Urodyn 26:481-5. 2007
    ..The aim of this study was to explore the physiologic relationship between anorectal and LUT function in healthy volunteers...
  36. ncbi Computed tomography urography technique, indications and limitations
    Sameh K Morcos
    Department of Diagnostic Imaging, Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
    Curr Opin Urol 17:56-64. 2007
    ..The review discusses the different techniques of computed tomography urography reported in the literature and presents the author's preferred approach...
  37. pmc Animal models in urological disease and sexual dysfunction
    Gordon McMurray
    Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Kent CT13 9NJ
    Br J Pharmacol 147:S62-79. 2006
    ..However, these models will only be fully validated in retrospect once the pharmacological agents they have helped identify are tested in humans...
  38. ncbi [Afferent pathways arising from the lower urinary tract. Physiology, pathophysiology, and clinical implications]
    A Reitz
    Urologische Klinik, Universitat, Heidelberg
    Urologe A 44:1452-7. 2005
    ..This review considers the current knowledge about normal and impaired sensations arising from the bladder and the sphincter and addresses their clinical significance...
  39. ncbi Pelvic somato-visceral reflexes after spinal cord injury: measures of functional loss and partial preservation
    Michael D Craggs
    Centre for Spinal Research, Functional Assessment and Restoration, London Spinal Cord Injuries Unit, Royal National Orthopaedic Hospital NHS Trust, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK
    Prog Brain Res 152:205-19. 2006
    ..Finally, the chapter will address the possible utility of neurophysiological measures for complementing the established neurological classification and the assessment of somatic sensory-motor impairment in SCI...
  40. ncbi Does the ostrich (Struthio camelus) coprodeum have the electrophysiological properties and microstructure of other birds?
    E Skadhauge
    Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, DK 1870 Copenhagen, Denmark
    Comp Biochem Physiol A Mol Integr Physiol 134:749-55. 2003
    ..ANATOMY: The mucosal membrane is composed of broad irregular folds with very short intestinal glands containing an unusually high proportion of goblet cells...
  41. ncbi Current practice patterns in the urologic surveillance and management of patients with spinal cord injury
    Sanjay Razdan
    Department of Urology and Spinal Cord Injury Unit, Miami VA Medical Center, University of Miami School of Medicine, Miami, Florida 33101, USA
    Urology 61:893-6. 2003
    ..There is a lack of consensus on the optimal urologic surveillance and management protocol of the urinary tract in SCI patients...
  42. ncbi Effects of urinary bladder distension on activity of T3-T4 spinal neurons receiving cardiac and somatic noxious inputs in rats
    Chao Qin
    Department of Physiology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Brain Res 971:210-20. 2003
    ..Results showed that T(3)-T(4) spinal neurons processing cardiac and somatic nociceptive information were primarily inhibited by input from the urinary bladder through either supraspinal structures or direct intraspinal pathways...
  43. ncbi Surgical treatment of renal artery dissection in 25 patients: indications and results
    Barbara Theresia Müller
    Department of Vascular Surgery and Kidney Transplantation, Heinrich Heine University Dusseldorf, Germany
    J Vasc Surg 37:761-8. 2003
    ..3 months (range, 10-111 months), were analyzed. Indications for surgery were renovascular hypertension and preservation or improvement of kidney function...
  44. ncbi Basolateral LAT-2 has a major role in the transepithelial flux of L-cystine in the renal proximal tubule cell line OK
    Esperanza Fernandez
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
    J Am Soc Nephrol 14:837-47. 2003
    ..This demonstrates that LAT-2 plays a major specific role in the net basolateral efflux of cysteine and points to LAT-2 as a candidate gene to modulate cystine reabsorption...
  45. ncbi Contemporary strategies to preserve renal function during cardiac and vascular surgery
    Roy Sheinbaum
    Department of Anesthesiology, The University of Texas Health Science Center, Houston, TX, USA
    Rev Cardiovasc Med 4:S21-8. 2003
    ....
  46. ncbi How acute renal failure puts the brakes on kidney function
    Diana Campbell
    Vancouver Island Health Authority Renal Program, British Columbia, Canada
    Nursing 33:59-63; quiz 64. 2003
    ..When you understand the various causes and life-threatening effects, you can support your patient's recovery...
  47. ncbi Pharmacologic perspective on the physiology of the lower urinary tract
    Karl Erik Andersson
    Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden
    Urology 60:13-20; discussion 20-1. 2002
    ..If this component of activation is responsible not only for part of the bladder contractions, but also for the symptoms of the overactive bladder, it should be considered an important target for therapeutic interventions...
  48. ncbi Muscle derived cell mediated ex vivo gene transfer to the lower urinary tract: comparison of viral vectors
    Ryan Pruchnic
    Department of Orthopedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Urol Res 30:310-6. 2002
    ..Our results suggest that the ex vivo approach may lead to an efficient and persistent viral gene delivery to the lower urinary tract while minimizing exposure of the host to virus...
  49. ncbi Pregnancy outcome and progression of diabetic nephropathy. What's next?
    J C Khoury
    Department of Environmental Health, University of Cincinnati College of Medicine, Ohio 45267 0056, USA
    J Matern Fetal Neonatal Med 11:238-44. 2002
    ....
  50. ncbi Is the male dog comparable to human? A histological study of the muscle systems of the lower urinary tract
    Jens Uwe Stolzenburg
    Department of Urology, University of Leipzig, Stephanstr 11, Germany
    Anat Histol Embryol 31:198-205. 2002
    ....
  51. ncbi Lower urinary tract physiology and pharmacology
    M E DiSanto
    Division of Urology, 3010 Ravdin Courtyard, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Curr Urol Rep 1:227-34. 2000
    ..In addition, the effects of diabetes, incontinence, and partial bladder outlet obstruction on these modes of contractile regulation are also discussed...
  52. ncbi Urinary tract infections. How to manage nursing home patients with or without chronic catheterization
    Judith A O'Donnell
    Department of Medicine, Division of Infectious Diseases, MCP Hahnemann School of Medicine and University, Medical College of Pennsylvania Hospital, Philadelphia, Pennsylvania, USA
    Geriatrics 57:45, 49-52, 55-6 passim. 2002
    ..Treatment of cystitis can usually be managed in the nursing home with oral antibiotics. Initial therapy with a parenteral agent is often recommended in nursing home-acquired pyelonephritis...
  53. ncbi Lower urinary-interleukin-1 receptor-antagonist excretion in IgA nephropathy than in Henoch-Schönlein nephritis
    Virpi Rauta
    Helsinki University Central Hospital, Department of Medicine, Division of Nephrology Helsinki, Finland
    Nephrol Dial Transplant 18:1785-91. 2003
    ..We studied levels of urinary excretion of IL-1beta and IL-1ra in patients with IgAN and HSN...
  54. ncbi Effects of manidipine and nifedipine on blood pressure and renal function in patients with chronic renal failure: a multicenter randomized controlled trial
    Guido Bellinghieri
    Chair and Division of Nephrology, School of Medicine, University of Messina Viale Gazzi, Messina, Italy
    Ren Fail 25:681-9. 2003
    ..5%). The withdrawal rate was not significantly different between the groups. Manidipine is equally safe and effective as nifedipine and it may have more activity on renal function and less severe side effects compared to nifedipine...
  55. ncbi A review of the L-arginine - nitric oxide - guanylate cyclase pathway as a mediator of lower urinary tract physiology and symptoms
    Lynn Stothers
    Department of Surgery, Division of Urology, University of British Columbia, Vancouver, British Columbia, Canada
    Can J Urol 10:1971-80. 2003
    ....
  56. ncbi Renal and antibacterial effects induced by myotoxin I and II isolated from Bothrops jararacussu venom
    P S F Barbosa
    Institute of Biomedicine and Clinical Research Unit, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil
    Toxicon 46:376-86. 2005
    ..In the other hand, other effects could be independently of the enzymatic activity of the BthTX II and the C-terminal domain could be involved in both effects promoted for PLA2...
  57. ncbi Management of bladder, prostatic and pelvic floor disorders with botulinum neurotoxin
    G Maria
    Department of Surgery, Catholic School of Medicine, University Hospital Agostino Gemelli, Rome, Italy
    Curr Med Chem 12:247-65. 2005
    ..In this paper, clinical experience over the last years with BoNT in urological impaired patients will be illustrated. Moreover, this paper presents current data on the use of BoNT to treat pelvic floor disorders...
  58. ncbi Partial nicotinic receptor blockade unmasks a modulatory role of nitric oxide on urethral striated neuromuscular transmission
    A Garcia-Pascual
    Department of Physiology, Veterinary School, Complutense University, Madrid, Spain
    Nitric Oxide 13:98-110. 2005
    ..This modulatory action could be especially relevant when neuromuscular transmission at the USM is impaired...
  59. ncbi Regulation of cyclic nucleotides in the urinary tract
    Marcia A Wheeler
    The Department of Surgery, Section of Urology, Yale University School of Medicine, New Haven, CT 06520 8041, USA
    J Smooth Muscle Res 41:1-21. 2005
    ..By exploitation of differences in PDE expression in disease, such as the overexpression of PDEs in cancer, treatment options may present themselves...
  60. ncbi [Upper urinary tract: physiology, pathophysiology of obstructions and function assessment]
    L Le Normand
    Clinique Urologique, CHRU, Hotel Dieu, Place Alexis Ricordeau, 44093 Nantes, France
    Ann Urol (Paris) 39:30-48. 2005
    ..Functional evaluations of the upper urinary tract are aimed at identify the urine transport conditions and the relationship between obstruction and clinical conditions such as hydronephrosis, pain or impaired renal function...
  61. ncbi Cystoscopy: techniques and clinical applications
    Jeannette S Messer
    Small Animal Internal Medicine Section, The Ohio State University College of Veterinary Medicine, Department of Vetennary Clinical Sciences, Columbus, Ohio 43210, USA
    Clin Tech Small Anim Pract 20:52-64. 2005
    ..This article reviews cystoscopy equipment, procedures, and common applications of cystoscopy. A review of normal anatomy and common lower urinary tract lesions identifiable with cystoscopy is also presented...
  62. ncbi Proceedings of the Baltimore smooth muscle meeting: identifying research frontiers and priorities for the lower urinary tract
    George J Christ
    Department of Urology, Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Urol 173:1406-9. 2005
    ..LUT diseases/disorders will continue to increase in an ever aging American population. The purpose of the Baltimore Smooth Muscle Meeting was to begin to identify some research frontiers and priorities...
  63. ncbi Overexpression of epithelial sodium channels in epithelium of human urinary bladder with outlet obstruction
    Isao Araki
    Department of Urology, University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, Tamaho, Yamanashi, Japan
    Urology 64:1255-60. 2004
    ..The increase of afferent activity is one of the possible mechanisms for this detrusor instability. The ENaC expressed in mammals has been implicated in various mechanosensory functions...
  64. ncbi Renal magnetic resonance imaging
    Henry Rusinek
    Department of Radiology, New York University Medical Center, Bellevue C and D building room D120, 550 First Avenue, New York, NY 10016, USA
    Curr Opin Nephrol Hypertens 13:667-73. 2004
    ..This article reviews the most important recently published studies in selected topics chosen because of their clinical relevance or potential for technical developments...
  65. ncbi Physiologic role of nitric oxide and nitric oxide synthase in female lower urinary tract
    Mat H Ho
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Curr Opin Obstet Gynecol 16:423-9. 2004
    ..This review discusses recently published data related to the physiologic and pathophysiologic roles of NO and nitric oxide synthase (NOS) in the female lower urinary tract...
  66. ncbi Anabolic effects of androgens on muscles of female pelvic floor and lower urinary tract
    Mat H Ho
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, David Geffen School of Medicine, University of California, Torrance, CA 90509, USA
    Curr Opin Obstet Gynecol 16:405-9. 2004
    ....
  67. ncbi Beneficial effect of aspirin on renal function post-cardiopulmonary bypass
    Rabin Gerrah
    Department of Cardiothoracic Surgery, Hebrew University Hadassah Medical School, PO Box 12000, Jerusalem 91120, Israel
    Asian Cardiovasc Thorac Ann 11:304-8. 2003
    ..6). Aspirin administrated before coronary surgery may have a beneficial effect on renal function, probably mediated by its antiplatelet activity and thromboxane inhibition...
  68. ncbi Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coli
    Lan Mo
    Dept of Urology, New York Univ School of Medicine, 423 East 23 St, 18th Floor, Rm 18064 South, New York, NY 10010, USA
    Am J Physiol Renal Physiol 286:F795-802. 2004
    ..The generation of THP-deficient mice established the role of THP as a first line of urinary defense and should help elucidate other potential functions of this major protein in urinary tract physiology and diseases.
  69. pmc Nitric oxide and relaxation of pig lower urinary tract
    K Persson
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Br J Pharmacol 106:416-22. 1992
    ..The importance of this pathway for lower urinary tract physiology and pathophysiology remains to be established.

Research Grants12

  1. Regulation of Skp2 Expression in Urinary Bladder Wall
    STEVEN WEINTRAUB; Fiscal Year: 2005
    ..If the bladder outlet obstruction is chronic, the hypertrophy becomes excessive. The derangement in urinary tract physiology that results from excessive bladder wall hypertrophy can result in such problems as chronic urinary tract ..
  2. CONFERENCE--FASEB SMOOTH MUSCLE
    KENTON SANDERS; Fiscal Year: 2000
    ..muscle function is vital to those interested in cardiovascular, respiratory, reproductive, digestive and urinary tract physiology and pathophysiology...
  3. Conference--Smooth Muscle
    Mark Nelson; Fiscal Year: 2003
    ..muscle function is vital to those interested in cardiovascular, respiratory, reproductive, digestive and urinary tract physiology and pathophysiology...
  4. Study of Intrinsic Bladder Activity by Optical Imaging
    Anthony Kanai; Fiscal Year: 2007
    ..To study the neural-chemical control of spontaneous detrusor activity; and III.) To determine the origin of detrusor overactivity in partially obstructed bladders. ..
  5. Sensory Testing in Subjects with Interstitial Cystitis
    Mary FitzGerald; Fiscal Year: 2004
    ..abstract_text> ..
  6. BOTULINUM TOXIN THERAPY FOR INTERSTITIAL CYSTITIS/CHRON*
    Mary FitzGerald; Fiscal Year: 2007
    ..abstract_text> ..
  7. Encapsulated siRNAs for treatment of urological disease
    Robert Weiss; Fiscal Year: 2008
    ..Thus, we can determine the therapeutic potential of siRNA for treatment of urologic diseases. [unreadable] [unreadable] [unreadable]..
  8. PTHrP on normal osteoblast differentiation and function
    RAMIRO TORIBIO; Fiscal Year: 2008
    ..Dr. Thomas Rosol's laboratory will provide an excellent environment for developing the skills necessary to become a successful independent researcher. ..
  9. Small Laboratory Animal Imaging: High Resolution Microcomputed Tomography System
    RAMIRO TORIBIO; Fiscal Year: 2006
    ..Salary and benefits for the Supervisor and Space and utilities for the instrument will be provided by Department of Veterinary Biosciences and the College of Veterinary Medicine. [unreadable] [unreadable]..
  10. AGE DEPENDENT FACTORS IN URETERAL-VESICAL FUNCTION
    Robert Weiss; Fiscal Year: 2002
    ..The determination of how age affects the function of the urinary tract and its response to pharmacologic agents may provide a rationale for the development of new drugs for the treatment of pathologic states. ..
  11. NITRIC OXIDE TRANSDUCTION MECHANISMS IN UTIS AND IC
    Robert Weiss; Fiscal Year: 2001
    ..The interpretation of the data obtained will not only pertain to infectious/inflammatory processes of he urinary tract, but also will facilitate the understanding of processes in humans which are less amenable to investigation. ..
  12. Bladder-specific Knockout and Gene Expression
    Xue ru Wu; Fiscal Year: 2009
    ..These studies will generate powerful experimental tools for studying bladder biology and diseases and offer molecular insights regarding urothelial growth and tumorigenesis. ..