sexual maturation


Summary: Achievement of full sexual capacity in animals and in humans.

Top Publications

  1. ncbi The GPR54 gene as a regulator of puberty
    Stephanie B Seminara
    Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 349:1614-27. 2003
  2. pmc Transcriptome profiling of testis during sexual maturation stages in Eriocheir sinensis using Illumina sequencing
    Lin He
    School of Life Sciences, East China Normal University, Shanghai, China
    PLoS ONE 7:e33735. 2012
  3. ncbi Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood
    Richard M Sharpe
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Chancellor s Building, University of Edinburgh, 49 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SB, UK
    Reproduction 125:769-84. 2003
  4. ncbi Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice
    Risto Lapatto
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Endocrinology 148:4927-36. 2007
  5. ncbi Pubertal hormones organize the adolescent brain and behavior
    Cheryl L Sisk
    Neuroscience Program and Department of Psychology, Michigan State University, East Lansing, MI, USA
    Front Neuroendocrinol 26:163-74. 2005
  6. ncbi The neural basis of puberty and adolescence
    Cheryl L Sisk
    Neuroscience Program and Department of Psychology, Michigan State University, East Lansing, Michigan 48824, USA
    Nat Neurosci 7:1040-7. 2004
  7. ncbi Exposure to juvenile stress exacerbates the behavioural consequences of exposure to stress in the adult rat
    Avi Avital
    Department of Psychology and The Brain and Behavior Research Center, University of Haifa, Mount Carmel, Haifa, Israel
    Int J Neuropsychopharmacol 8:163-73. 2005
  8. ncbi Comparison between objective assessment and self-assessment of sexual maturation in children and adolescents
    Jenner C V Azevedo
    Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil
    J Pediatr (Rio J) 85:135-42. 2009
  9. ncbi Altered sexual maturation and gamete production in wild roach (Rutilus rutilus) living in rivers that receive treated sewage effluents
    S Jobling
    Department of Biological Sciences, Brunel University, Uxbridge, Middlesex UB8 3PH, United Kingdom
    Biol Reprod 66:272-81. 2002
  10. pmc Pubertal development: correspondence between hormonal and physical development
    Elizabeth A Shirtcliff
    Department of Psychology, University of New Orleans, 2000 Lakeshore Drive, New Orleans, LA 70148, USA
    Child Dev 80:327-37. 2009

Detail Information

Publications336 found, 100 shown here

  1. ncbi The GPR54 gene as a regulator of puberty
    Stephanie B Seminara
    Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 349:1614-27. 2003
    ..We conducted studies in humans and mice to identify the genetic factors that determine the onset of puberty...
  2. pmc Transcriptome profiling of testis during sexual maturation stages in Eriocheir sinensis using Illumina sequencing
    Lin He
    School of Life Sciences, East China Normal University, Shanghai, China
    PLoS ONE 7:e33735. 2012
    ..This is the first report of a mitten crab transcriptome using high-throughput sequencing technology, and all these testes transcripts can help us understand the molecular mechanisms involved in spermatogenesis and testis maturation...
  3. ncbi Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood
    Richard M Sharpe
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Chancellor s Building, University of Edinburgh, 49 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SB, UK
    Reproduction 125:769-84. 2003
  4. ncbi Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice
    Risto Lapatto
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Endocrinology 148:4927-36. 2007
    ..Gpr54 and its ligand metastin (derived from the Kiss1 gene product kisspeptin) are key gatekeepers of sexual maturation. Gpr54 knockout mice demonstrate hypogonadotropic hypogonadism, but until recently, the phenotype of Kiss1 ..
  5. ncbi Pubertal hormones organize the adolescent brain and behavior
    Cheryl L Sisk
    Neuroscience Program and Department of Psychology, Michigan State University, East Lansing, MI, USA
    Front Neuroendocrinol 26:163-74. 2005
  6. ncbi The neural basis of puberty and adolescence
    Cheryl L Sisk
    Neuroscience Program and Department of Psychology, Michigan State University, East Lansing, Michigan 48824, USA
    Nat Neurosci 7:1040-7. 2004
    ..Reproductive maturity is therefore the product of developmentally timed, brain-driven and recurrent interactions between steroid hormones and the adolescent nervous system...
  7. ncbi Exposure to juvenile stress exacerbates the behavioural consequences of exposure to stress in the adult rat
    Avi Avital
    Department of Psychology and The Brain and Behavior Research Center, University of Haifa, Mount Carmel, Haifa, Israel
    Int J Neuropsychopharmacol 8:163-73. 2005
    ..These results indicate that an exposure to a relatively brief juvenile stressful experience has profound and long-lasting effects on the ability to cope with stress in adulthood...
  8. ncbi Comparison between objective assessment and self-assessment of sexual maturation in children and adolescents
    Jenner C V Azevedo
    Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil
    J Pediatr (Rio J) 85:135-42. 2009
    To assess the correlations between objective assessment and self-assessment of sexual maturation in the outpatient and school settings.
  9. ncbi Altered sexual maturation and gamete production in wild roach (Rutilus rutilus) living in rivers that receive treated sewage effluents
    S Jobling
    Department of Biological Sciences, Brunel University, Uxbridge, Middlesex UB8 3PH, United Kingdom
    Biol Reprod 66:272-81. 2002
  10. pmc Pubertal development: correspondence between hormonal and physical development
    Elizabeth A Shirtcliff
    Department of Psychology, University of New Orleans, 2000 Lakeshore Drive, New Orleans, LA 70148, USA
    Child Dev 80:327-37. 2009
    ..The PDS and PBIP were similarly related to basal hormones. Self-report may be adequate when precise agreement is unnecessary. Multiple measures of puberty are viable options, each with respective strengths...
  11. ncbi Diets high in corn oil or extra-virgin olive oil provided from weaning advance sexual maturation and differentially modify susceptibility to mammary carcinogenesis in female rats
    Raquel Moral
    Department of Cell Biology, Physiology and Immunology, Physiology Unit, Medicine School, Universitat Autonoma de Barcelona, Barcelona, Spain
    Nutr Cancer 63:410-20. 2011
    ..Our data suggest a strong influence of the HCO diet in sexual maturation and mammary cancer risk, while rats fed the HOO diet were more similar to the controls.
  12. ncbi Is obesity associated with early sexual maturation? A comparison of the association in American boys versus girls
    Youfa Wang
    Department of Human Nutrition and Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Pediatrics 110:903-10. 2002
    Increasing evidence suggests a close association between early sexual maturation (SM) and obesity in girls and female adults. Earlier maturing girls are more likely to be obese than nonearly maturers...
  13. pmc A critical role for alpha4betadelta GABAA receptors in shaping learning deficits at puberty in mice
    Hui Shen
    Department of Physiology and Pharmacology, State University of New York SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Science 327:1515-8. 2010
    ..Thus, the emergence of alpha4betadelta GABARs at puberty impairs learning, an effect that can be reversed by a stress steroid...
  14. ncbi Longitudinal growth, sexual maturation and final height in patients with congenital hypothyroidism detected by neonatal screening
    M Salerno
    Department of Pediatrics, University of Naples Federico II, Italy
    Eur J Endocrinol 145:377-83. 2001
    ..To evaluate longitudinal growth, pubertal development and final height in patients with congenital hypothyroidism (CH) detected by a neonatal screening programme, and to identify factors potentially affecting growth outcome...
  15. ncbi Reliability of pubertal self-assessment in Hong Kong Chinese children
    Noel P T Chan
    The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
    J Paediatr Child Health 44:353-8. 2008
    ..To validate a Tanner stages self-assessment questionnaire using gender-specific line drawings and brief explanatory text in Chinese...
  16. ncbi Self-assessment of sexual maturation in Thai children by Tanner photograph
    Suttipong Wacharasindhu
    Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    J Med Assoc Thai 85:308-19. 2002
    Assessment of sexual maturation in adolescence is crucially important in clinical practice, because the possibility of concealed disease during the earlier period of child development needs to be detected...
  17. ncbi Lanosterol 14alpha-demethylase expression in the mouse ovary and its participation in cumulus-enclosed oocyte spontaneous meiotic maturation in vitro
    Chao Wang
    Department of Animal Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100094, PR China
    Theriogenology 66:1156-64. 2006
  18. ncbi Physical and pubertal development in young male gymnasts
    Brendon Gurd
    Department of Physical Education and Kinesiology, Brock University, St Catharines, ON, Canada L2S 3A1
    J Appl Physiol 95:1011-5. 2003
    The purpose of this study was to evaluate the effect of intense training on physical growth and sexual maturation in young male gymnasts...
  19. ncbi Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states
    J Roa
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    Am J Physiol Endocrinol Metab 294:E1088-96. 2008
    ..These observations of potential pharmacological interest might help also to delineate the physiological roles of kisspeptins in the dynamic regulation of gonadotropin secretion in the female...
  20. pmc Body weight impact on puberty: effects of high-calorie diet on puberty onset in female rhesus monkeys
    Ei Terasawa
    Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, Wisconsin 53715 1299, USA
    Endocrinology 153:1696-705. 2012
    ..The findings of this study suggest the importance of close monitoring of juvenile feeding behaviors as an important intervention to reduce the prevalence of precocious development and metabolic diseases in adulthood...
  21. pmc Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains
    Rong Yuan
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 109:8224-9. 2012
    ..Here we report that strains with lower IGF1 have significantly delayed age of female sexual maturation, measured by vaginal patency (VP)...
  22. ncbi Testosterone cannot activate an adult-like stress response in prepubertal male rats
    Russell D Romeo
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY, USA
    Neuroendocrinology 79:125-32. 2004
    ..Thus, we conclude that the HPA neuroendocrine axis is further shaped during pubertal development to allow for the emergence of a more tightly regulated stress response in adulthood...
  23. ncbi Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
    S Dupont
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 163, France
    Development 127:4277-91. 2000
    ..Our results also show that cell proliferation in the prostate and urinary bladder of old ERbetaKO and ERalphabetaKO males is apparently normal...
  24. pmc Divergent roles of growth factors in the GnRH regulation of puberty in mice
    Sara A DiVall
    Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland 21212, USA
    J Clin Invest 120:2900-9. 2010
    ..These studies define the role of IGF-1R signaling in the coordination of somatic development with reproductive maturation and provide insight into the mechanisms regulating pubertal timing in anabolic states...
  25. pmc Swimming physiology of European silver eels (Anguilla anguilla L.): energetic costs and effects on sexual maturation and reproduction
    Arjan P Palstra
    Molecular Cell Biology, Institute of Biology, Leiden University IBL, Leiden, The Netherlands
    Fish Physiol Biochem 36:297-322. 2010 a pre-pubertal state and reproduce after swimming for months, a strong interaction between swimming and sexual maturation is expected...
  26. pmc Transcriptome profiling of sexual maturation and mating in the Mediterranean fruit fly, Ceratitis capitata
    Ludvik M Gomulski
    Department of Animal Biology, University of Pavia, Pavia, Italy
    PLoS ONE 7:e30857. 2012
    b>Sexual maturation and mating in insects are generally accompanied by major physiological and behavioural changes...
  27. pmc Plasticity of the chemoreceptor repertoire in Drosophila melanogaster
    Shanshan Zhou
    Department of Biology, North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS Genet 5:e1000681. 2009
    ..This finely pixilated modular organization of the chemosensory subgenome enables fine tuning of the expression of the chemoreceptor repertoire in response to ecologically relevant environmental and physiological conditions...
  28. ncbi Normal female sexual development requires neuregulin-erbB receptor signaling in hypothalamic astrocytes
    Vincent Prevot
    Division of Neuroscience, Oregon Regional Primate Research Center Oregon Health Sciences University, Beaverton, Oregon 97006, USA
    J Neurosci 23:230-9. 2003
    ..Mice carrying the transgene exhibit delayed sexual maturation and a diminished reproductive capacity in early adulthood...
  29. ncbi Glial-neuronal-endothelial interactions are involved in the control of GnRH secretion
    Vincent Prevot
    Division of Neuroscience, Oregon Regional Primate Research Center Oregon Health Science University, Beaverton, 97006 USA
    J Neuroendocrinol 14:247-55. 2002
    ..It is clear that regulation of GnRH secretion by cell-cell communication mechanisms other than transsynaptic inputs is an important component of the central neuroendocrine process controlling mammalian reproduction...
  30. ncbi Repetitive activation of hypothalamic G protein-coupled receptor 54 with intravenous pulses of kisspeptin in the juvenile monkey (Macaca mulatta) elicits a sustained train of gonadotropin-releasing hormone discharges
    Tony M Plant
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Endocrinology 147:1007-13. 2006
  31. ncbi Identification of quantitative trait loci affecting female reproductive traits in a multigeneration Meishan-White composite swine population
    G A Rohrer
    USDA, ARS, U S Meat Animal Research Center, Clay Center, NE 68933 0166, USA
    J Anim Sci 77:1385-91. 1999
    ..Further analyses of other populations of swine are necessary to determine the extent of allelic variation at the identified QTL...
  32. ncbi Selection of oocytes for in vitro maturation by brilliant cresyl blue staining: a study using the mouse model
    Yan Guang Wu
    Laboratory for Animal Reproduction and Embryology, College of Animal Science and Vet Medicine, Shandong Agricultural University, Tai an, Shandong, China
    Cell Res 17:722-31. 2007
    ..Taken together, the series of criteria described here would allow for better choices in selecting oocytes for better development...
  33. pmc Adolescent female rats exhibiting activity-based anorexia express elevated levels of GABA(A) receptor α4 and δ subunits at the plasma membrane of hippocampal CA1 spines
    Chiye Aoki
    Center for Neural Science, New York University, New York, New York 10003, USA
    Synapse 66:391-407. 2012
    ..The observed magnitude of increase in the α4 and δ subunits at spines is sufficient to increase both tonic inhibition of hippocampus and anxiety during stress, thereby likely to exacerbate hyperactivity and weight loss...
  34. ncbi Life-history correlates of extinction risk and recovery potential
    Jeffrey A Hutchings
    Department of Biology, Dalhousie University Halifax, Nova Scotia B3H 4J1, Canada
    Ecol Appl 22:1061-7. 2012
    ..Our findings are supportive of the application of extinction-risk criteria that are based on generation time and that are independent of taxonomic affinity...
  35. ncbi Seasonal and social correlates of fecal testosterone and cortisol levels in wild male muriquis (Brachyteles arachnoides)
    K B Strier
    Department of Anthropology, University of Wisconsin Madison, 1180 Observatory Drive, Madison, Wisconsin 53706, USA
    Horm Behav 35:125-34. 1999
  36. ncbi Family environments, adrenarche, and sexual maturation: a longitudinal test of a life history model
    Bruce J Ellis
    Division of Family Studies and Human Development, John and Doris Norton School of Family and Consumer Sciences, University of Arizona, PO Box 210033, Tucson, AZ 85721 0033, USA
    Child Dev 78:1799-817. 2007
    ..Consistent with a life history perspective, quality of parental investment emerged as a central feature of the proximal family environment in relation to pubertal timing...
  37. pmc Differential annual movement patterns in a migratory species: effects of experience and sexual maturation
    Paulo E Jorge
    Unidade de Investigação em Eco etologia, ISPA Instituto Universitário, Lisboa, Portugal
    PLoS ONE 6:e22433. 2011
    ..Processes such as sexual maturation and navigational abilities are affected by age, and age is thus a key factor in understanding migration ..
  38. ncbi Mother-daughter communication about sexual maturation, abstinence and unintended pregnancy: experiences from an informal settlement in Nairobi, Kenya
    Joanna Crichton
    African Population and Health Research Center, Nairobi, Kenya
    J Adolesc 35:21-30. 2012
    ..This study explores the quality of mother-daughter communication about sexual maturation, abstinence and unintended pregnancy in Korogocho, an informal settlement in Nairobi, Kenya...
  39. ncbi Assessment of physical activity among rural Senegalese adolescent girls: influence of age, sexual maturation, and body composition
    E Benefice
    Epidémiologie et Prévention, Centre IRD Institut de Recherche pour le Developpement, anciennement ORSTOM de Montpellier, France
    J Adolesc Health 28:319-27. 2001
    ..To analyze the level of habitual physical activity and its relationship with age, maturational stage, and growth status in a group of adolescent Senegalese girls...
  40. ncbi Offspring from one-month-old lambs: studies on the developmental capability of prepubertal oocytes
    G Ptak
    Istituto Zootecnico e Caseario per la Sardegna, 07040 Olmedo, Sassari, Italy
    Biol Reprod 61:1568-74. 1999
    ..Defects in the competence of lamb-derived embryos may account for the increased fetal loss during pregnancy and the occurrence of mummified fetuses delivered alongside normal healthy lambs...
  41. ncbi [Prevalence of overweight and abdominal obesity according to anthropometric parameters and the association with sexual maturation in adolescent schoolchildren]
    Isabel Carolina da Silva Pinto
    Universidade Federal de Pernambuco, Recife, Brasil
    Cad Saude Publica 26:1727-37. 2010
    ..prevalence of overweight and abdominal obesity in schoolchildren according to anthropometric parameters and sexual maturation. A cross-sectional study was performed in 1,405 children of both genders aged 10-14 years, living in Recife, ..
  42. ncbi Growth and maturation of adolescent female gymnasts, swimmers, and tennis players
    Marta C Erlandson
    College of Kinesiology, University of Saskatchewan, Saskatoon, Canada
    Med Sci Sports Exerc 40:34-42. 2008
    Intensive training at a young age may adversely affect the growth and sexual maturation of female athletes, resulting in compromised adult stature.
  43. ncbi Effects of age and experience on mating activity in the sibling species Drosophila pavani and Drosophila gaucha
    S Koref-Santibáñez
    Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago
    Behav Genet 31:287-97. 2001
    ..It is longer in Drosophila pavani than in Drosophila gaucha and is determined mainly by the male. The duration of copula increases with age, especially in Drosophila pavani females, whereas it is reduced in males of the same species...
  44. ncbi Seasonal changes of brain GnRH-I, -II, and -III during the final reproductive period in adult male and female sea lamprey
    Stacia A Sower
    Center for Molecular and Comparative Endocrinology, University of New Hampshire, Durham, NH 03824, USA
    Gen Comp Endocrinol 170:276-82. 2011
    ..e., they spawn only once in their lifetime, after which they die. Sexual maturation is thus a synchronized process coordinated with the life stages of the lamprey...
  45. pmc Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons
    Jose Donato
    Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9077, USA
    J Clin Invest 121:355-68. 2011
    ..of the ventral premammillary nucleus (PMV) of ob/ob mice blunted the ability of exogenous leptin to induce sexual maturation. Moreover, unilateral reexpression of endogenous LepR in PMV neurons was sufficient to induce puberty and ..
  46. ncbi Sertoli cell function in albino rats treated with etoposide during prepubertal phase
    Taiza Stumpp
    Federal University of Sao Paulo, 740, Botucatu, Sao Paulo, SP, Brazil
    Histochem Cell Biol 126:353-61. 2006
    ..We concluded that the diminution of transferrin labeling in the seminiferous epithelium was not associated with germ cell absence such as commonly reported. The results suggest etoposide impairs Sertoli cell function...
  47. ncbi A single nucleotide polymorphism-derived regulatory gene network underlying puberty in 2 tropical breeds of beef cattle
    M R S Fortes
    School of Veterinary Science, The University of Queensland, Gatton Campus, Queensland 4343, Australia
    J Anim Sci 89:1669-83. 2011
    ..Finally, we support our network predictions with evidence derived from gene expression in hypothalamic tissue of adult cows...
  48. ncbi Early onset of reproductive function in normal female mice treated with leptin
    F F Chehab
    Department of Laboratory Medicine, University of California, 505 Parnassus Avenue, San Francisco, CA 94143 0134, USA
    Science 275:88-90. 1997
    ..These results suggest that leptin acts as a signal triggering puberty, thus supporting the hypothesis that fat accumulation enhances maturation of the reproductive tract...
  49. pmc The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice
    David H Volle
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Centre National de la Recherche Scientifique CNRS Institut National de la Santé et de la Recherche Médicale INSERM Université Louis Pasteur ULP, 67404 Illkirch, France
    Genes Dev 21:303-15. 2007
    ..Together, our data demonstrate new roles for SHP in testicular androgen and retinoic acid metabolism, making SHP a testicular gatekeeper of the timing of male sexual maturation.
  50. pmc Leptin action in pubertal development: recent advances and unanswered questions
    Carol F Elias
    Department of Internal Medicine, Division of Hypothalamic Research and Green Center for Reproductive Biology Sciences, University of Texas Southwestern UTSW Medical Center, Dallas, TX 75390, USA
    Trends Endocrinol Metab 23:9-15. 2012
    ..It will also emphasize areas of contention and the many relevant questions that remain unanswered...
  51. ncbi Male orangutan subadulthood: a new twist on the relationship between chronic stress and developmental arrest
    Anne N Maggioncalda
    Department of Anthropological Sciences, Stanford University, California 94305 2117, USA
    Am J Phys Anthropol 118:25-32. 2002
    ..1999], [2000]...
  52. ncbi Leuprolide stimulation testing for the evaluation of early female sexual maturation
    Anpalakan Sathasivam
    Pediatric Endocrinology and Diabetes, Mount Sinai School of Medicine, New York, NY 10029, USA
    Clin Endocrinol (Oxf) 73:375-81. 2010
    ..Low concentrations of serum LH and/or oestradiol (E(2)) in girls with early physical signs of precocious puberty pose a diagnostic challenge...
  53. ncbi Thelarche variant: a new syndrome of precocious sexual maturation?
    R Stanhope
    Department of Growth and Development, Middlesex Hospital, London, UK
    Acta Endocrinol (Copenh) 123:481-6. 1990
    We describe 10 girls (mean age 3.7 years, range 1.9-6.9) with precocious sexual maturation and clinical findings intermediate between those of premature thelarche and central precocious puberty...
  54. ncbi Gonadotrophin-inhibitory hormone receptor expression in the chicken pituitary gland: potential influence of sexual maturation and ovarian steroids
    S Maddineni
    Department of Poultry Science, The Pennsylvania State University, University Park, PA 16802, USA
    J Neuroendocrinol 20:1078-88. 2008
    ..the expression of GnIHR mRNA and protein in the chicken pituitary gland, and to determine whether sexual maturation and gonadal steroids influence pituitary GnIHR mRNA abundance...
  55. ncbi Effects of maternal undernutrition on the hypothalamic-pituitary-gonadal axis function in female sheep offspring
    B Kotsampasi
    Laboratory of Anatomy and Physiology of Domestic Animals, Department of Animal Science, Agricultural University of Athens, Athens, Greece
    Reprod Domest Anim 44:677-84. 2009
  56. ncbi Gonadal hormones masculinize and defeminize reproductive behaviors during puberty in the male Syrian hamster
    Kalynn M Schulz
    Department of Psychology and Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
    Horm Behav 45:242-9. 2004
    ..These studies demonstrate that gonadal hormones during puberty further masculinize and defeminize neural circuits and behavioral responsiveness to steroid hormones in adulthood...
  57. ncbi Dietary patterns are associated with sexual maturation in Korean children
    Shan Ji Li
    Human Ecology Research Center, Department of Food and Nutrition, Seoul National University, Seoul, Korea
    Br J Nutr 95:817-23. 2006
    The purpose of this study was to investigate the association between dietary patterns and sexual maturation among Korean children. A cross-sectional study was conducted in 422 boys and 365 girls aged 9-12 years living in Seoul, Korea...
  58. ncbi Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: a review of rodent and human data
    G Rasier
    Developmental Neuroendocrinology Unit, Center for Cellular and Molecular Neurobiology, University of Liege, University Hospital Center, B36, 1, B 4000 Liege Sart Tilman, Belgium
    Mol Cell Endocrinol 254:187-201. 2006
    ..The impact of such exposures on the hypothalamic-pituitary-gonadal axis and subsequent sexual maturation is the subject of the present review...
  59. ncbi Colony-stimulating factor 1 regulation of neuroendocrine pathways that control gonadal function in mice
    Paula E Cohen
    Center for the Study of Reproductive Biology and Women s Health, Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Endocrinology 143:1413-22. 2002
    ..These data suggest a role for CSF-1 and its target cells, microglia, in establishing the feedback sensitivity to circulating steroid hormones in the hypothalamus of mice...
  60. ncbi Characterization of reproduction-specific genes in a marine bivalve mollusc: influence of maturation stage and sex on mRNA expression
    Isabelle Boutet
    Laboratoire des Sciences de l Environnement Marin, Institut Universitaire Europeen de la Mer, Universite de Bretagne Occidentale, Place Nicolas Copernic, Plouzane, France
    Gene 407:130-8. 2008
    ..This is the first time that the expression of specific genes involved in reproduction mechanisms in a marine mollusc has been described at the molecular level...
  61. ncbi Internal exposure to pollutants and sexual maturation in Flemish adolescents
    Elly Den Hond
    Flemish Institute of Technological Research, Environmental Risk and Health, Boeretang 200, B 2400 Mol, Belgium
    J Expo Sci Environ Epidemiol 21:224-33. 2011
    Flanders is densely populated with much industry and intensive farming. Sexual maturation of adolescents (aged 14-15 years) was studied in relation to internal exposure to pollutants...
  62. ncbi Earlier onset of puberty in girls: relation to increased body mass index and race
    P B Kaplowitz
    Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Pediatrics 108:347-53. 2001
  63. ncbi Meiotic and developmental competence of prepubertal and adult swine oocytes
    R Marchal
    Station de Physiologie de la Reproduction et des Comportements, INRA, Nouzilly, France
    Theriogenology 56:17-29. 2001
    ..In conclusion, although prepubertal gilt oocytes appeared less meiotically and developmentally competent than their adult counterparts, they can be used to produce blastocysts able to develop to term...
  64. ncbi Molecular identification and functional characterization of the kisspeptin/kisspeptin receptor system in lower vertebrates
    Jakob Biran
    Department of Animal Sciences, The Hebrew University, 76100 Rehovot, Israel
    Biol Reprod 79:776-86. 2008
    ..The human KISS1R was highly activated by both huKISS10amide and zfKISS10amide, whereas both zebrafish Kiss1 receptor types were less sensitive to amidation...
  65. ncbi Neuroendocrinology of reproduction in teleost fish
    Yonathan Zohar
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD, USA
    Gen Comp Endocrinol 165:438-55. 2010
    ..interplay between external and internal factors that will ultimately influence the triggering of puberty and sexual maturation. Among these factors are sex steroids and other peripheral hormones and growth factors, but little is known ..
  66. pmc Back to the future: The organizational-activational hypothesis adapted to puberty and adolescence
    Kalynn M Schulz
    Department of Psychiatry and Developmental Psychobiology Program, University of Colorado, Denver Anschutz Medical Campus, Aurora, CO 80045, USA
    Horm Behav 55:597-604. 2009
    ..The implications for human adolescent development are also discussed, especially with respect to how animal models can help to elucidate the factors underlying the association between pubertal timing and adult psychopathology in humans...
  67. ncbi QTL analysis of a red junglefowl x White Leghorn intercross reveals trade-off in resource allocation between behavior and production traits
    Karin Schutz
    Swedish University of Agricultural Sciences, Department of Animal Environment and Health, Section of Ethology, POB 234, SE 532 23 Skara, Sweden
    Behav Genet 32:423-33. 2002
    ..The results suggest a trade-off between energy-demanding behavior and high production and that some of this may be caused by genetic linkage or pleiotropic gene effects...
  68. pmc Blood lead levels and sexual maturation in U.S. girls: the Third National Health and Nutrition Examination Survey, 1988-1994
    Tiejian Wu
    Department of Public Health Family Medicine, East Tennessee State University, Johnson City, Tennessee 37614 1709, USA
    Environ Health Perspect 111:737-41. 2003
    ..S. girls in relation to blood lead levels to determine whether sexual maturation may be affected by current environmental lead exposure...
  69. ncbi Gene expression profiling of hypothalamic hamartomas: a search for genes associated with central precocious puberty
    Anne Simone Parent
    Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Horm Res 69:114-23. 2008
    ..Because HHs might express genes similar to those required for the initiation of normal puberty, we used cDNA arrays to compare the gene expression profile of an HH associated with CPP with three HHs not accompanied by sexual precocity...
  70. ncbi Sexual maturation data for Crl Sprague-Dawley rats: criteria and confounding factors
    Elise M Lewis
    Argus Research, A Division of Charles River Laboratories, 905 Sheehy Drive, Bldg A, Horsham, PA 19044, USA
    Drug Chem Toxicol 25:437-58. 2002
    ..g., balanopreputial separation and vaginal opening)...
  71. ncbi Determination of onset of sexual maturation and mating behavior by melanocortin receptor 4 polymorphisms
    Kathrin P Lampert
    Physiological Chemistry I, Biocenter, University of Wuerzburg, Am Hubland, D 97074 Wuerzburg, Germany
    Curr Biol 20:1729-34. 2010
    ..Because Mc4r is critically involved in regulation of body weight and appetite, a novel link between the physiological system controlling energy balance and the regulation of reproduction becomes apparent...
  72. ncbi IGF-I: an essential factor in terminal end bud formation and ductal morphogenesis
    D L Kleinberg
    Department of Medicine, New York University School of Medicine and Department of Veterans Affairs Medical Center, New York 10010, USA
    J Mammary Gland Biol Neoplasia 5:7-17. 2000
    ..GH-induced IGF-I is of major importance in ductal morphogenesis, and may, in fact, be necessary for later stages of mammary development, as well...
  73. ncbi Distribution of prepubertal and adult goat oocyte cortical granules during meiotic maturation and fertilisation: ultrastructural and cytochemical study
    E Velilla
    Departament de Ciencia Animal i dels Aliments, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Mol Reprod Dev 68:507-14. 2004
    ..Images by TEM detected that CGs were more electrodense and compacts in oocytes from prepubertal than from adult goats...
  74. ncbi Fish age at maturation is influenced by temperature independently of growth
    Anna Kuparinen
    Ecological Genetics Research Unit, Department of Biosciences, University of Helsinki, Helsinki, Finland
    Oecologia 167:435-43. 2011
    ..Therefore, one cannot predict, on the basis of growth only, how changes in temperature might alter age and size at maturation and the subsequent reproduction...
  75. ncbi Regulation of ovarian steroidogenesis in vitro by follicle-stimulating hormone and luteinizing hormone during sexual maturation in salmonid fish
    J V Planas
    School of Fisheries, University of Washington, Seattle, Washington 98195, USA
    Biol Reprod 62:1262-9. 2000
    ..In summary, we have provided evidence for maturation-associated changes in the effects of FSH and LH in the salmonid ovary, which further supports the hypothesis that FSH and LH have distinct functions in the teleost ovary...
  76. ncbi Kisspeptin activates the hypothalamic-adenohypophyseal-gonadal axis in prepubertal ewe lambs
    J S Redmond
    Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Reproduction 141:541-8. 2011
    ..Results support a role for kisspeptin in the activation of the hypothalamic-adenohypophyseal axis leading to the onset of puberty in ewe lambs...
  77. pmc Relationships of putative endocrine disruptors to human sexual maturation and thyroid activity in youth
    Lawrence M Schell
    University at Albany, Department of Anthropology, Albany, NY 12222, USA
    Physiol Behav 99:246-53. 2010
    ..HCB and mirex), and heavy metals (lead and mercury), to outcomes directly related to thyroid function and sexual maturation. These studies were conducted in a sample of Native American youth from the Akwesasne Mohawk community...
  78. ncbi Gonad development during the early life of Octopus maya (Mollusca: Cephalopoda)
    Omar Hernando Avila-Poveda
    Posgrado en Ciencias del Mar y Limnología ICMyL, Universidad Nacional Autonoma de Mexico UNAM, Puerto de abrigo S N, Sisal, Yucatan, Mexico
    Biol Bull 216:94-102. 2009
  79. ncbi [Sexual maturation of children and adolescents in Germany. Results of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS)]
    H Kahl
    Robert Koch Institut, Berlin, BRD
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 50:677-85. 2007
    ..Survey for Children and Adolescents (KiGGS) is intended to pro vide population-representative information on sexual maturation and to evaluate associations between maturity status and selected health and social data...
  80. ncbi Adrenarche in the rat
    Duarte Pignatelli
    Laboratório de Biologia Celular e Molecular da Faculdade de Medicina da Universidade do Porto and IBMC, Alameda Hernani Monteiro, 4200 319 Porto, Portugal
    J Endocrinol 191:301-8. 2006
    ..The results suggest that the rat adrenal has the capacity to secrete steroids arising from 17-hydroxylation, and that this may contribute to a process similar to human adrenarche...
  81. ncbi The Oct-2 POU domain gene in the neuroendocrine brain: a transcriptional regulator of mammalian puberty
    S R Ojeda
    Division of Neuroscience, Oregon Regional Primate Research Center Oregon Health Sciences University, Beaverton 97006, USA
    Endocrinology 140:3774-89. 1999
    ..These results suggest that the Oct-2 gene is one of the upstream components of the glia to neuron signaling process that controls the onset of female puberty in mammals...
  82. ncbi Regionally selective effects of gonadectomy on cortical catecholamine innervation in adult male rats are most disruptive to afferents in prefrontal cortex
    M F Kritzer
    Department of Neurobiology and Behavior, State University of New York at Stony Brook, 11794 5230, USA
    Cereb Cortex 9:507-18. 1999
    ..In adult male rats, this sensitivity is also marked by a seemingly selective vulnerability of catecholamine innervation in prefrontal areas to changes in the hormone environment induced by gonadectomy...
  83. pmc The transcriptional control of female puberty
    Sergio R Ojeda
    Division of Neuroscience, Oregon National Primate Research Center Oregon Health and Science University, 505 N W 185th Avenue, Beaverton, OR 97006, USA
    Brain Res 1364:164-74. 2010
    ..More recently, we have begun to explore the concept that a more dynamic and encompassing level of integrative coordination is provided by epigenetic mechanisms...
  84. ncbi Diet and social conditions during sexual maturation have unpredictable influences on female life history trade-offs
    E L B Barrett
    Centre for Ecology and Conservation, University of Exeter, Cornwall Campus, Penryn, UK
    J Evol Biol 22:571-81. 2009
    ..the ovoviviparous cockroach, Nauphoeta cinerea, revealed that females manipulated to mate late relative to sexual maturation experience age-related loss in fecundity because of loss of viable oocytes via apoptosis...
  85. ncbi Evidence for genomic and nongenomic actions of estrogen in growth plate regulation in female and male rats at the onset of sexual maturation
    B C J van der Eerden
    Department of Pediatrics, Leiden University Medical Center, The Netherlands
    J Endocrinol 175:277-88. 2002
    ..Recently, both estrogen receptor (ER) alpha and beta were detected in growth plate chondrocytes of rats before sexual maturation, implying a role for estrogen at this stage...
  86. ncbi The kisspeptin/gonadotropin-releasing hormone pathway and molecular signaling of puberty in fish
    Amy L Filby
    Environmental and Molecular Fish Biology Group, School of Biosciences, Hatherly Laboratories, University of Exeter, Exeter, Devon, EX4 4PS, United Kingdom
    Biol Reprod 78:278-89. 2008
  87. ncbi Anthropometry and body composition in ethnic Japanese and Caucasian adolescent boys
    Miriam A Sampei
    Postgraduate Course in Nutrition, Federal University of Sao Paulo, Paulista School of Medicine, Sao Paulo, Brazil
    Pediatr Int 50:679-86. 2008
  88. ncbi Growth differences and dimorphic expression of growth hormone (GH) in female and male Cynoglossus semilaevis after male sexual maturation
    Xiang Shan Ji
    Key Laboratory for Sustainable Utilization Development of Marine Fisheries, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China
    Mar Genomics 4:9-16. 2011
    ..Significant differences in body weight between the sexes were found after early sexual maturation of males at the age of 9 months. The body weight of 21-month-old females (621.4 ± 86...
  89. ncbi Changes in ectonucleotidase activities in rat Sertoli cells during sexual maturation
    Emerson André Casali
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Mol Cell Biochem 247:111-9. 2003
    ..ATP and ADP hydrolysis was increased 3-fold during sexual maturation. AMP hydrolysis increased 4-fold in 10- to 35-day-old Sertoli cells...
  90. ncbi Sexual maturation in the bull
    N Rawlings
    Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Reprod Domest Anim 43:295-301. 2008
    In this review, we describe the process of sexual maturation in the bull calf. The testes of the bull grow relatively slowly until approximately 25 weeks of age and then a rapid phase of growth occurs until puberty, at 37-50 weeks of age...
  91. ncbi [Effects of sexual maturation on body composition, dermatoglyphics, somatotype and basic physical qualities of adolescents]
    Renato Vidal Linhares
    Laboratório de Biociências da Motricidade Humana, Universidade Castelo Branco, Rio de Janeiro, RJ, Brazil
    Arq Bras Endocrinol Metabol 53:47-54. 2009
    Describe the characteristics of body composition, somatotype, basic physical qualities, dermatoglyphics and bone age regarding sexual maturation stages of boys.
  92. pmc Effect of the aqueous extract of Senecio biafrae (Oliv. & Hiern) J. Moore on sexual maturation of immature female rat
    Landry L Lienou
    University of Dschang, Faculty of Science, Department of Biochemistry, Cameroon
    BMC Complement Altern Med 12:36. 2012
    ..biafrae (AESb) on the onset of puberty and some biochemical and physiological parameters of reproduction in immature Wistar female rats...
  93. ncbi Growth hormone and thyroid stimulating hormone concentrations in captive male orangutans: implications for understanding developmental arrest
    A N Maggioncalda
    Department of Anthropological Sciences, Stanford University, California 94305 2145, USA
    Am J Primatol 50:67-76. 2000
  94. ncbi Sertoli cell morphological alterations in albino rats treated with etoposide during prepubertal phase
    Taiza Stumpp
    Laboratory of Developmental Biology, Federal University of Sao Paulo, 740 Botucatu, Ed Leitao da Cunha, Sao Paulo SP 04023 900, Brazil
    Microsc Microanal 14:225-35. 2008
    ..Some Sertoli cells also showed nuclear and cytoplasmic degenerative characteristics, suggesting that etoposide causes severe damages to Sertoli cell...
  95. ncbi Persistent impairment of testicular histology and sperm motility in adult rats treated with Cisplatin at peri-puberty
    Ana Paula Alves Favareto
    Program of Cellular and Structural Biology, State University of Campinas UNICAMP, SP, Brazil
    Basic Clin Pharmacol Toxicol 109:85-96. 2011
  96. ncbi Effect of altering dose of PG600 on reproductive performance responses in prepubertal gilts and weaned sows
    S M Breen
    Department of Animal Sciences, University of Illinois, Champaign Urbana, IL 61801 3939, USA
    Anim Reprod Sci 95:316-23. 2006
    ..Reducing dose of PG600 for weaned sows did not alter estrus or ovulation, but the 0.5x dose increased farrowing rate compared to no PG600...
  97. ncbi Expression of gonadotropin and gonadotropin receptor genes during early sexual maturation in male Atlantic salmon parr
    Gersende Maugars
    Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences, Umea, Sweden
    Mol Reprod Dev 75:403-13. 2008
    Atlantic salmon males may mature already as small parr in freshwater. Sexual maturation in teleosts as in vertebrates is characterized by the activation of the brain-pituitary-gonad axis...
  98. ncbi Ameliorative effect of vitamin C on hexavalent chromium-induced delay in sexual maturation and oxidative stress in developing Wistar rat ovary and uterus
    Jawahar B Samuel
    Department of Zoology, St John s College, Thirunelveli, Tamil Nadu, India
    Toxicol Ind Health 28:720-33. 2012
    ..CrVI exposure also delayed the sexual maturation and extended the estrous cycle...
  99. pmc Amifostine reduces the seminiferous epithelium damage in doxorubicin-treated prepubertal rats without improving the fertility status
    Vanessa Vendramini
    Department of Morphology and Genetics, Federal University of Sao Paulo UNIFESP, Sao Paulo SP, Brazil
    Reprod Biol Endocrinol 8:3. 2010
  100. ncbi Effect of subcutaneous vs intramuscular administration of P.G. 600 on estrual and ovulatory responses of prepubertal gilts
    R V Knox
    Department of Animal Sciences, University of Illinois, Champaign Urbana 61801 3939, USA
    J Anim Sci 78:1732-7. 2000
    ..Results of this study indicated that s.c. administration of P.G. 600 significantly improved the induction of estrus in prepubertal gilts compared to i.m. administration...
  101. ncbi Changes in the responsiveness of luteinizing hormone secretion to infusion of the opioid antagonist naloxone throughout male sexual maturation
    A Ulloa Aguirre
    Department of Reproductive Biology, National Institute of Nutrition S Zubiran, Mexico City, Mexico
    Clin Endocrinol (Oxf) 29:17-28. 1988
    The present study investigated the time of male sexual maturation during which hypothalamic inhibitory opioid activity can be detected...

Research Grants62

  1. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..have found that re-expression of LepR selectively in the ventral premammillary nucleus (PMV) induce puberty, sexual maturation and improve fertility...
  2. Growth hormone and adult physiology
    Rhonda D Kineman; Fiscal Year: 2013 normal subjects, 1) developmental GHD, that might not reflect the consequences of GH decline after sexual maturation and 2) adult onset GHD (AOGHD) which is frequently accompanied by other pituitary defects, making it ..
  3. Calcium Signaling in the Pubertal Activation of the GnRH Pulse Generator
    Daniel J Spergel; Fiscal Year: 2011
    ..the mechanism(s) of the pubertal increase in gonadotropin- releasing hormone (GnRH) secretion required for sexual maturation and fertility...
  4. Dioxins and Male Pubertal Growth and Development
    Russ B Hauser; Fiscal Year: 2013
    ..of dioxins, furans, PCBs and lead with: 1) progression of male pubertal development and age at attainment of sexual maturation (measured by testicular volume and Tanner stages);2) somatic growth, specifically height, height velocity, ..
  5. Timing of Exposure to Selenium and Isoflavones and Prostate Cancer Prevention
    EDWIN DOUGLAS LEPHART; Fiscal Year: 2010
    ..that exposure begun at conception produces beneficial effects not seen when exposure is started after sexual maturation. To identify biochemical and molecular mechanisms for those effects, attention will focus on processes ..
  6. Neonatal Programming of Growth and Maturation in Rhesus Monkeys
    Andrew Muir; Fiscal Year: 2013
    ..young progeny, owing to compensatory increases in energy expenditure (physical activity, linear growth, or sexual maturation)...
  7. Neuroendocrine regulation of the reproductive axis during puberty and development
    Alexander S Kauffman; Fiscal Year: 2013
    ..maturation and earlier developmental stages remain poorly understood, as does the reason for earlier sexual maturation in girls than boys...
  8. Neural basis of leptin action on reproduction
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..Deletion of Kiss1 or Kiss1r genes results in hypogonadism, abnormal sexual maturation and decreased circulating levels of sex steroids and gonadotropins...
  9. Childhood Obesity and Sexual Maturation
    Shumei S Sun; Fiscal Year: 2010
    ..continuation of the project R01HD38356 Sexual Maturity in US Children which is a cross-sectional study of sexual maturation and body weight, height, and BMI...
  10. Axon, Testosterone and Mental Health during Adolescence
    Tomas Paus; Fiscal Year: 2013
    ..1) To evaluate whether or not the timing &dynamics of sexual maturation during early and mid-adolescence predicts structural properties of white matter during late adolescence...
  11. Early Life Determinants of Accelerated Pubertal Development in Adolescent Girls
    Ai Kubo; Fiscal Year: 2013
    ..of mothers'and daughters'electronic health data in an on-going prospective study of predictors of sexual maturation in adolescent girls (U01 ES/CA019435) (Study 1);and, 2...
  12. The Role of GPR54 Signaling in Pubertal Disorders
    SUZY DRUMOND CARVALHO BIANCO; Fiscal Year: 2010 genetic mutations of this receptor affect these mechanisms and hence the timing of pubertal onset and sexual maturation. Specifically, the aims of this proposal are to: (1) Define the mechanisms of GPR54 desensitization, ..
  13. The role of FGF signaling in neuroendocrine control of reproduction
    Nelly Pitteloud; Fiscal Year: 2012
    ..idiopathic hypogonadotropic hypogonadism [nIHH]) have provided unique insights into the genes controlling sexual maturation (KAL1, GNRHR, FGFR1, and GPR54)...
    Joseph P Moore; Fiscal Year: 2011
    b>Sexual maturation in the male is a complex process that involves changes in the hypothalamus, pituitary, testes, and secondary sexual organs and in their interrelationships...
  15. Maternally Transmitted Opiate Abuse Vulnerability
    Elizabeth M Byrnes; Fiscal Year: 2013
    ..use may also significantly impact the reproductive axis given the role that endogenous opioids play in both sexual maturation and reproductive function...
  16. Imaging Brain, Neurocognitive and Pubertal Maturation During Adolescence
    Elizabeth R Sowell; Fiscal Year: 2013
    ..affect processing), neurocognitive (with emphasis on executive functioning and cognitive control), physical sexual maturation (using Tanners staging), and hormonal (cortisol, testosterone, estrogen and Dehydroepiandrosterone (DHEA) ..
  17. The CYGNET Study: Enviromental and Genetic Determinants of Maturation of Girls
    Lawrence H Kushi; Fiscal Year: 2013
    ..and genetic factors may play important roles in modifying age-at-onset of puberty and other hallmarks of sexual maturation. This cohort study is thus focused on determining factors that are associated with various milestones in ..
  18. Breast Cancer and the Environment Research Center
    SANDRA HASLAM; Fiscal Year: 2009
    ..exposures to environmental stressors that affect the timing of pubertal development and sexual maturation impact on breast cancer risk...
  19. Effect of Puberty on the Phamacokinetics of Efavirenz in HIV-infected Children
    ..Aim 2: Evaluate the relationship of developmental changes during puberty (measured by somatic growth and sexual maturation) to CYP2B6 activity (determined by the formation clearance of EFV to its metabolite 8-hydroxyefavirenz) in ..
  20. Pubertal control of GnRH neurons
    KELLY J SUTER; Fiscal Year: 2012
    ..inputs to GnRH neurons emerges during the peripubertal period and accounts for differences in tempo of the sexual maturation. Identifying the substrate that accounts for this difference and the mechanisms that modulate the ..
  21. Input to GnRH1 neurons: Changes in synaptic identity and connectivity at sexual m
    Russ E Carpenter; Fiscal Year: 2012
    ..b>Sexual maturation is an important biological development that prepares an organism for reproductively active adult life stages...
  22. Coordinating Center for the Pediatric HIV/AIDS Cohort Study II
    RUSSELL BARRETT VAN DYKE; Fiscal Year: 2013
    ..adolescents with perinatal HIV (1) to define the impact of HIV infection and ART on: growth and development;sexual maturation;pubertal development;development of risk factors for cardiovascular disease;cognitive, academic, vocational, ..
    HUGH KEEPING; Fiscal Year: 1991
    ..mRNA levels for the inhibin subunits, as well as ABP, will be measured in five developmental stages of sexual maturation. These mRNA values will then be compared with the concentration of inhibin in the testes, determined by ..
    HELEN I ANSON; Fiscal Year: 1993
    The overall objective is to understand the mechanisms whereby growth- related cues influence the rate of sexual maturation and onset of puberty...
    Margaret E Wierman; Fiscal Year: 2010
    ..of the TAM member and/or ligand during both early GnRH neuron development and their impact on the timing of sexual maturation and reproductive competence...
  26. Perinatal exposures, epigenetics, child obesity &sexual maturation
    KAREN EILEEN PETERSON; Fiscal Year: 2012
    ANNA STEINBERGER; Fiscal Year: 1991
    ..Our hypothesis is that vectorial secretory patterns of Sc products and their regulation change during sexual maturation and that these changes may be important for the initiation of spermatogenesis...
  28. Pediatric HIV/AIDS Cohort Study (PHACS) Data and Operations Center (DOC)
    George R Seage; Fiscal Year: 2013
    ..Master Protocol, AMP, age 7-16 at enrollment) was established to evaluate the impact of HIV and ART on sexual maturation, pubertal development, and socialization;and, a drug toxicity surveillance system (Surveillance Monitoring ..
    Kathleen Ryan; Fiscal Year: 1990
    Although disorders of sexual maturation are relatively rare, they are by no means trivial, nor are they well understood - primarily because the mechanisms underlying sexual maturation have not been fully revealed in the human or any ..
    Leslie Kaufman; Fiscal Year: 1992
    ..bone growth: Aim 1: To determine whether FH in the crevalle jack, Caranx hippos, is correlated to state of sexual maturation and/or levels of circulating gonadotropic hormones...
    Susan Robinson; Fiscal Year: 1999
    ..Developmental milestones and sexual maturation will be assessed. Antinociception/nociception (tail- flick, hot-plate) in the weanling and adult rats...
    ALEX POORMAN; Fiscal Year: 2011
    ..and conditions of children, such as mental retardation and developmental delay, autism, asthma, delayed sexual maturation, behavior disorders, obesity, and injuries...
    Bonny Specker; Fiscal Year: 2012
    ..and conditions of children, such as mental retardation and developmental delay, autism, asthma, delayed sexual maturation, behavior disorders, obesity, and injuries...
  34. The role of the vascular endothelium in schistosomiasis
    Melissa Beall; Fiscal Year: 2002
    ..Previous studies suggest that Schistosoma mansoni requires host-derived factors for normal development and sexual maturation. Understanding the intricate interactions between host and parasite may suggest methods to prevent the ..
  35. Mouse model of adult-onset, isolated, GH-deficiency
    RHONDA KINEMAN; Fiscal Year: 2009
    ..of 1) developmental GH-deficiency, which may differ from that resulting in GH-deficiency occuring after sexual maturation and 2) adult-onset, GH- deficiency, which is typically associated with panhypopituitarism...
    Gayle Windham; Fiscal Year: 2001
    ..shown effects of alcohol on the endocrine system of adults and there is suggestive evidence it may effect sexual maturation. Known actions of caffeine present plausible mechanisms for alteration of hormonal profiles and an ..
    Marvin Mitchell; Fiscal Year: 1993
    ..The second specific aim is to document physical growth and sexual maturation of hypothyroid children through puberty and beyond the period of peak growth velocity...
    Douglas Foster; Fiscal Year: 1980
    ..and body weight on the mechanism governing sensitivity to the negative feedback of estradiol during sexual maturation will be investigated...
    ANITA PAYNE; Fiscal Year: 1993
    ..2) the role of prolactin in the regulation of 5Alpha-reductase activity in purified rat Leydig cells during sexual maturation; and 3) the mechanism by which cAMP brings about steroidogenic desensitization using a newly developed mouse ..
    Robert Anderson; Fiscal Year: 1992
    ..have shown that chronic ethanol ingestion by sexually immature male mice and rats delays the process of sexual maturation. The work proposed in the present application is aimed at the evaluation of putative mechanisms for this ..
  41. Molecular Genetics of the HPA(I) Axis
    Phillip Danielson; Fiscal Year: 2002
    ..for the post-spawning demise of these fish, studies have now implicated overproduction of cortisol during sexual maturation as the factor which ultimately leads to the demise of spawning salmon...
  42. Athletics & Eating Problems in Native & Caucasian Youth
    Wesley Lynch; Fiscal Year: 2003
    ..behaviors depending on ethnicity, type and level of athletic involvement, and the individual's level of sexual maturation. A proposed structural equation model (SEM) expressing specific hypotheses about various potential risk ..
  43. Defining a Role for ATM in the Nervous System
    Carrolee Barlow; Fiscal Year: 2004
    ..These include immunodeficiency, hematolymphopoietic malignancies, growth retardation, incomplete sexual maturation, oculocutaneous telangiectasias, sensitivity to ionizing radiation and premature aging...
    STEVEN YELLON; Fiscal Year: 1990
    ..The male Djungarian hamster, as the animal model, provides an unique opportunity for this proposal because sexual maturation is profoundly influenced by photoperiod; changes in day length can delay or initiate puberty...
    Mark Wise; Fiscal Year: 1992
    ..Since the mechanisms that regulate gonadotropin secretion during adulthood develop during sexual maturation, this project will probe the ontogeny of these regulatory systems and their cellular and molecular ..
  46. Prenatal pesticide exposure in South Africa: CNS Effects
    Roberta White; Fiscal Year: 2005
    ..environmental exposures to them and some pesticides are well established as endocrine disruptors, affecting sexual maturation during prenatal growth and in children...
  47. Gender-Specific Treatment of Pediatric Cardiac Arrest
    Robert Clark; Fiscal Year: 2009
    ..of gender in the pathobiology of hypoxic-ischemic encephalopathy after cardiopulmonary arrest prior to sexual maturation has not been thoroughly addressed...
    Varadaraj Chandrashekar; Fiscal Year: 2000 men, congenital GH resistance is due to mutated GH receptors (Laron syndrome) is associated with delay in sexual maturation, suggesting a role of GH in reproduction...
    James DeWille; Fiscal Year: 1999
    ..levels during three principal proliferative phases in normal mouse mammary gland development: embryonic, sexual maturation and during pregnancy/lactation. (2) Investigate the influence of varying corn oil (CO) intake [5, 12...
    Paule Barbeau; Fiscal Year: 2004
    ..e., self-efficacy and self-concept); C7) sexual maturation; (8) anthropometric measures...
    EMILIE RISSMAN; Fiscal Year: 1990
    ..these animals nutritional, photoperiodic, and social variables have varying effects on various measures of sexual maturation. However, the vast majority of mammalian species evolved and still live in the tropics...
    Hiroko Nishimura; Fiscal Year: 2007
    ..higher with maturation in male chicks, whereas in females, PWV was restored to lower levels after sexual maturation. AIM I is to elucidate hemodynamic and molecular factors selective for NP-prone regions by examining whether ..
  53. Novel Actions of Estradiol that Influence Brain Function
    Paul G Mermelstein; Fiscal Year: 2010
    Estradiol plays a critical role in sexual maturation and receptivity...
    Andrzej Bartke; Fiscal Year: 2001
    ..GH-R-KO mice as a model system for identifying the role of GH-dependent IGF-I production in the control of sexual maturation, and for more clearly defining the role of GH-dependent (presumably brain and gonadal rather than hepatic) ..
    THOMAS MERIMEE; Fiscal Year: 1991
    ..role of these factors in normal growth and development, particularly as they relate to pubertal growth and sexual maturation. In the first category above, we will study the actions of the insulin-like growth factors (IGF I and IGF II)..
    Mary Leonard; Fiscal Year: 2001
    ..will explore for effect modification and adjust for possible confounding effects of impaired growth and sexual maturation, calcium intake, vitamin D status, physical activity, and cyclosporin therapy...
    RUSSELL FERNALD; Fiscal Year: 1993
    The research proposed here addresses internal and external regulators of sexual maturation in vertebrates...
    URSULA KAISER; Fiscal Year: 2006
    ..signals between the hypothalamus, the pituitary and the gonads are necessary for successful mammalian sexual maturation and reproduction...
  59. The Regulation ACRP30 and Adult Reproductive Development
    Terry Combs; Fiscal Year: 2003
    ..The elevation of ACRP3O may therefore be associated with changes in glucose homeostasis that occur during sexual maturation. Furthermore, elevated levels of ACRP3O in adult females may be associated with their increased insulin ..
    STEVEN GABRIEL; Fiscal Year: 1991
    ..models to test the hypotheses that galanin is an antidopaminergic neuroeffector, that galanin influences sexual maturation of the brain at puberty and that galanin participates in the mediation of estrogen feedback...
  61. Early life antecedents of adult chronic disease
    Karen Remsberg; Fiscal Year: 2005
    ..Factors associated with these risk patterns, such as aspects of body composition, sexual maturation, physical activity and other traditional cardiovascular disease risk factors, will be investigated...
    Sharyne Donfield; Fiscal Year: 2000
    ..elucidate the effects of HIV on physical growth and development by studying stature, growth velocity and sexual maturation. b) To determine whether disturbances in physical growth (decreased stature, growth velocity, delays in ..