puberty

Summary

Summary: A period in the human life in which the development of the hypothalamic-pituitary-gonadal system takes place and reaches full maturity. The onset of synchronized endocrine events in puberty lead to the capacity for reproduction (FERTILITY), development of secondary SEX CHARACTERISTICS, and other changes seen in ADOLESCENT DEVELOPMENT.

Top Publications

  1. ncbi The GPR54 gene as a regulator of puberty
    Stephanie B Seminara
    Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 349:1614-27. 2003
  2. ncbi Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice
    Sandra Giovanoli
    Physiology and Behavior Laboratory, Swiss Federal Institute of Technology ETH Zurich, 8603 Schwerzenbach, Switzerland
    Science 339:1095-9. 2013
  3. ncbi Childhood obesity and the timing of puberty
    M Lynn Ahmed
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Cambridge, CB2 0QQ, UK
    Trends Endocrinol Metab 20:237-42. 2009
  4. ncbi Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels
    Antje Böttner
    Research Laboratory, University Hospital for Children and Adolescents, University of Leipzig, Oststrasse 21 25, 04317 Leipzig, Germany
    J Clin Endocrinol Metab 89:4053-61. 2004
  5. pmc Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates
    Muhammad Shahab
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 102:2129-34. 2005
  6. ncbi Performance of a new pubertal self-assessment questionnaire: a preliminary study
    S J Taylor
    Department of General Practice and Primary Care, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, UK
    Paediatr Perinat Epidemiol 15:88-94. 2001
  7. ncbi The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration
    Anne Simone Parent
    Division of Ambulatory Pediatrics and Adolescent Medicine, University of Liege, B 4000 Liege, Belgium
    Endocr Rev 24:668-93. 2003
  8. ncbi Longitudinal study of physiologic insulin resistance and metabolic changes of puberty
    Tamara S Hannon
    Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus and Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Pediatr Res 60:759-63. 2006
  9. ncbi The neural basis of puberty and adolescence
    Cheryl L Sisk
    Neuroscience Program and Department of Psychology, Michigan State University, East Lansing, Michigan 48824, USA
    Nat Neurosci 7:1040-7. 2004
  10. ncbi Growth at puberty
    Alan D Rogol
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA
    J Adolesc Health 31:192-200. 2002

Detail Information

Publications353 found, 100 shown here

  1. ncbi The GPR54 gene as a regulator of puberty
    Stephanie B Seminara
    Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 349:1614-27. 2003
    b>Puberty, a complex biologic process involving sexual development, accelerated linear growth, and adrenal maturation, is initiated when gonadotropin-releasing hormone begins to be secreted by the hypothalamus...
  2. ncbi Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice
    Sandra Giovanoli
    Physiology and Behavior Laboratory, Swiss Federal Institute of Technology ETH Zurich, 8603 Schwerzenbach, Switzerland
    Science 339:1095-9. 2013
    ....
  3. ncbi Childhood obesity and the timing of puberty
    M Lynn Ahmed
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Cambridge, CB2 0QQ, UK
    Trends Endocrinol Metab 20:237-42. 2009
    The potential relationship between childhood obesity and earlier puberty onset has major public health implications. Earlier menarche in girls is associated with increased risk of adult obesity, type 2 diabetes and breast cancer...
  4. ncbi Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels
    Antje Böttner
    Research Laboratory, University Hospital for Children and Adolescents, University of Leipzig, Oststrasse 21 25, 04317 Leipzig, Germany
    J Clin Endocrinol Metab 89:4053-61. 2004
    ..0001). Hence, there is a strong association of adiponectin serum concentrations with obesity, pubertal development, and metabolic parameters in children indicating epidemiological and pathophysiological relevance already in childhood...
  5. pmc Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates
    Muhammad Shahab
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 102:2129-34. 2005
    To further study the role of GPR54 signaling in the onset of primate puberty, we used the monkey to examine the ability of kisspeptin-10 to elicit the release of gonadotropin-releasing hormone (GnRH) precociously, and we describe the ..
  6. ncbi Performance of a new pubertal self-assessment questionnaire: a preliminary study
    S J Taylor
    Department of General Practice and Primary Care, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, UK
    Paediatr Perinat Epidemiol 15:88-94. 2001
    ..questionnaire that aims to measure pubertal status by using gender-specific line drawings of the Tanner puberty stages...
  7. ncbi The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration
    Anne Simone Parent
    Division of Ambulatory Pediatrics and Adolescent Medicine, University of Liege, B 4000 Liege, Belgium
    Endocr Rev 24:668-93. 2003
    During the past decade, possible advancement in timing of puberty has been reported in the United States...
  8. ncbi Longitudinal study of physiologic insulin resistance and metabolic changes of puberty
    Tamara S Hannon
    Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus and Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Pediatr Res 60:759-63. 2006
    ..Children had repeat evaluations during puberty. Consistent with cross-sectional observations, this longitudinal study demonstrated that during puberty: 1) ..
  9. ncbi The neural basis of puberty and adolescence
    Cheryl L Sisk
    Neuroscience Program and Department of Psychology, Michigan State University, East Lansing, Michigan 48824, USA
    Nat Neurosci 7:1040-7. 2004
    ..energy balance and season, time the awakening of gonadotropin releasing hormone (GnRH) neurons at the onset of puberty. High-frequency GnRH release results from disinhibition and activation of GnRH neurons at puberty onset, leading ..
  10. ncbi Growth at puberty
    Alan D Rogol
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA
    J Adolesc Health 31:192-200. 2002
    ..b>Puberty is a dynamic period of development marked by rapid changes in body size, shape, and composition, all of which are ..
  11. ncbi Longitudinal study on pubertal insulin resistance
    M I Goran
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Diabetes 50:2444-50. 2001
    Previous cross-sectional studies show that puberty is associated with a reduction in insulin sensitivity (S(I)), but no longitudinal studies have examined this change in detail...
  12. ncbi Earlier onset of puberty in girls: relation to increased body mass index and race
    P B Kaplowitz
    Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Pediatrics 108:347-53. 2001
    ..Office Settings network provided evidence that girls in the United States, especially black girls, are starting puberty at a younger age than earlier studies had found, but the reasons for this are not known...
  13. ncbi Recent decline in age at breast development: the Copenhagen Puberty Study
    Lise Aksglaede
    Rigshospitalet, Department of Growth and Reproduction GR, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Pediatrics 123:e932-9. 2009
    ..Here we present new European data systematically collected from the same region and by 1 research group at the beginning and end of the recent 15-year period...
  14. pmc SITAR--a useful instrument for growth curve analysis
    Tim J Cole
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, UK
    Int J Epidemiol 39:1558-66. 2010
    Growth curve analysis is a statistical issue in life course epidemiology. Height in puberty involves a growth spurt, the timing and intensity of which varies between individuals...
  15. pmc Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54
    V M Navarro
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain
    J Physiol 561:379-86. 2004
    The awakening of the gonadotrophic axis at puberty is the end-point of a complex cascade of sex developmental events that leads to the attainment of reproductive capacity...
  16. ncbi Effect of gender, puberty, and vitamin D status on biochemical markers of bone remodedeling
    Jocelyne Eid Fares
    Calcium Metabolism and Osteoporosis Program, Department of Internal Medicine, American University of Beirut Medical Center, Bliss Street, Beirut, Lebanon
    Bone 33:242-7. 2003
    ..We systematically evaluated the impact of puberty, gender, and vitamin D status on biochemical markers of bone remodeling...
  17. pmc Age before stage: insulin resistance rises before the onset of puberty: a 9-year longitudinal study (EarlyBird 26)
    Alison N Jeffery
    University Medicine, Peninsula Medical School, Plymouth, UK
    Diabetes Care 35:536-41. 2012
    Insulin resistance (IR) is associated with diabetes. IR is higher during puberty in both sexes, with some studies showing the increase to be independent of changes in adiposity...
  18. ncbi Growth, body composition, and the onset of puberty: longitudinal observations in Afro-Caribbean children
    Michael S Boyne
    Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston 7, Jamaica, West Indies
    J Clin Endocrinol Metab 95:3194-200. 2010
    Childhood growth and body composition may influence the onset of puberty.
  19. pmc Predicting female depression across puberty: a two-nation longitudinal study
    George C Patton
    Centre for Adolescent Health, Murdoch Childrens Research Institute, Parkville, Australia
    J Am Acad Child Adolesc Psychiatry 47:1424-32. 2008
    ..To prospectively examine the relation between pubertal stage and the onset and course of depressive symptoms...
  20. ncbi The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system
    J Roa
    Physiology Section, Department of Cell Biology, Physiology, and Immunology, Faculty of Medicine, University of Cordoba, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Endocrinology 150:5016-26. 2009
    ..We provide herein evidence for the involvement of mTOR in the control of puberty onset and LH secretion, likely via modulation of hypothalamic expression of Kiss1...
  21. ncbi Association between the insulin resistance of puberty and the insulin-like growth factor-I/growth hormone axis
    Antoinette Moran
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Clin Endocrinol Metab 87:4817-20. 2002
    To test the hypothesis that the relative insulin resistance of puberty is associated with changes in IGF-I levels, we compared IGF-I, IGF binding protein-3 (IGFBP-3), and IGFBP-1 levels to insulin resistance [M(lbm), milligrams glucose ..
  22. pmc Puberty influences medial temporal lobe and cortical gray matter maturation differently in boys than girls matched for sexual maturity
    Jennifer E Bramen
    Developmental Cognitive Neuroimaging Group, Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cereb Cortex 21:636-46. 2011
    Sex differences in age- and puberty-related maturation of human brain structure have been observed in typically developing age-matched boys and girls...
  23. ncbi Insulin resistance during puberty: results from clamp studies in 357 children
    A Moran
    Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    Diabetes 48:2039-44. 1999
    ..However, children normally experience transient insulin resistance at puberty. There were 357 normal children (159 girls, 198 boys) age 10-14 years who underwent euglycemic clamp studies to ..
  24. pmc Pubertal development: correspondence between hormonal and physical development
    Elizabeth A Shirtcliff
    Department of Psychology, University of New Orleans, 2000 Lakeshore Drive, New Orleans, LA 70148, USA
    Child Dev 80:327-37. 2009
    b>Puberty is advanced by sex hormones, yet it is not clear how it is best measured...
  25. pmc Percent body fat at age 5 predicts earlier pubertal development among girls at age 9
    Kirsten Krahnstoever Davison
    Department of Human Development and Family Studies, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Pediatrics 111:815-21. 2003
    ..This study examines the causal direction of the relationship between weight status and pubertal timing in girls using a longitudinal sample of 183 white girls followed from ages 5 to 9...
  26. ncbi Association between puberty and delayed phase preference
    M A Carskadon
    Department of Psychiatry and Human Behavior, E. P. Bradley Hospital/Brown University, E. Providence, Rhode Island 02915
    Sleep 16:258-62. 1993
    ..These data support involvement of a biological factor in the adolescent phase preference delay and indicate that our current understanding of adolescent sleep patterns may need revision...
  27. ncbi Metabolic control of puberty onset: new players, new mechanisms
    Juan Roa
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    Mol Cell Endocrinol 324:87-94. 2010
    b>Puberty, as the end-point of a complex series of maturational events affecting the components of the hypothalamic-pituitary-gonadal (HPG) axis, is gated by the state of body energy reserves and sensitive to different metabolic cues; ..
  28. ncbi Neurobiological mechanisms of the onset of puberty in primates
    E Terasawa
    Department of Pediatrics, Wisconsin Regional Primate Research Center, and University of Wisconsin Madison, 53715 1299, USA
    Endocr Rev 22:111-51. 2001
    An increase in pulsatile release of LHRH is essential for the onset of puberty. However, the mechanism controlling the pubertal increase in LHRH release is still unclear...
  29. ncbi Vaspin is related to gender, puberty and deteriorating insulin sensitivity in children
    A Korner
    Department of Women and Child Health, University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
    Int J Obes (Lond) 35:578-86. 2011
    ..Visceral adipose tissue-derived serine protease inhibitor (vaspin) has been suggested as a novel adipocytokine related to obesity and insulin sensitivity in adults...
  30. ncbi Beyond overweight: nutrition as an important lifestyle factor influencing timing of puberty
    Guo Cheng
    Research Institute of Child Nutrition, Rheinische Friedrich Wilhelms University Bonn, Heinstueck 11, Dortmund, Germany
    Nutr Rev 70:133-52. 2012
    Early onset of puberty may confer adverse health consequences. Thus, modifiable factors influencing the timing of puberty are of public health interest...
  31. pmc Dioxin and polychlorinated biphenyl concentrations in mother's serum and the timing of pubertal onset in sons
    Olivier Humblet
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 22:827-35. 2011
    ..Animal studies have demonstrated that timing of pubertal onset can be altered by prenatal exposure to dioxins or polychlorinated biphenyls (PCBs), but studies of human populations have been quite limited...
  32. ncbi Role of nutritional status in the regulation of adrenarche
    T Remer
    Research Institute of Child Nutrition, Dortmund, Germany
    J Clin Endocrinol Metab 84:3936-44. 1999
    ..rates of dehydroepiandrosterone sulfate (DHEAS) in a prepuberty (PreC; n = 22, 11 boys and 11 girls) and a puberty (PubC; n = 20, 10 boys and 10 girls) cohort of healthy children...
  33. ncbi Physical and pubertal development in young male gymnasts
    Brendon Gurd
    Department of Physical Education and Kinesiology, Brock University, St Catharines, ON, Canada L2S 3A1
    J Appl Physiol 95:1011-5. 2003
    ....
  34. ncbi Reliability of pubertal self-assessment in Hong Kong Chinese children
    Noel P T Chan
    The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
    J Paediatr Child Health 44:353-8. 2008
    ..To validate a Tanner stages self-assessment questionnaire using gender-specific line drawings and brief explanatory text in Chinese...
  35. ncbi Lead exposure is associated with a delay in the onset of puberty in South African adolescent females: findings from the Birth to Twenty cohort
    Nisha Naicker
    Medical Research Council of South Africa, Environment and Health Research Unit, PO Box 87373, Houghton, 2041, Johannesburg, South Africa
    Sci Total Environ 408:4949-54. 2010
    ..In South Africa blood lead levels are generally higher than in resource-rich countries. Thus the effects of lead exposure on pubertal development may be significant...
  36. ncbi Is obesity associated with early sexual maturation? A comparison of the association in American boys versus girls
    Youfa Wang
    Department of Human Nutrition and Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Pediatrics 110:903-10. 2002
    ..Earlier maturing girls are more likely to be obese than nonearly maturers. However, limited research has been conducted in boys...
  37. ncbi Influence of puberty on muscle development at the forearm
    C M Neu
    Children s Hospital, University of Cologne, 50924 Cologne, Germany
    Am J Physiol Endocrinol Metab 283:E103-7. 2002
    ..In conclusion, forearm muscle growth takes a gender-specific course during puberty, indicating that it is influenced by hormonal changes...
  38. pmc Dioxin exposure and age of pubertal onset among Russian boys
    Susan A Korrick
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 119:1339-44. 2011
    ..Animal data demonstrate associations of dioxin, furan, and polychlorinated biphenyl (PCB) exposures with altered male gonadal maturation. It is unclear whether these associations apply to human populations...
  39. ncbi Associations between a single nucleotide polymorphism of the FTO Gene (rs9939609) and obesity-related characteristics over time during puberty in a Dutch children cohort
    Femke Rutters
    Maastricht University, Department of Human Biology, P O Box 616, 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 96:E939-42. 2011
    ..The influence of single nucleotide polymorphisms (SNP) of the FTO gene has been shown to change over time...
  40. pmc Mutations of the KISS1 gene in disorders of puberty
    L G Silveira
    Unidade de Endocrinologia do Desenvolvimento, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP 05403 900, Brasil
    J Clin Endocrinol Metab 95:2276-80. 2010
    Kisspeptin, encoded by the KISS1 gene, is a key stimulatory factor of GnRH secretion and puberty onset. Inactivating mutations of its receptor (KISS1R) cause isolated hypogonadotropic hypogonadism (IHH)...
  41. pmc Obesity and sex steroid changes across puberty: evidence for marked hyperandrogenemia in pre- and early pubertal obese girls
    Christopher R McCartney
    Center for Research in Reproduction, Box 800391, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 92:430-6. 2007
    ..Peripubertal obesity is associated with abnormal sex steroid concentrations, but the timing of onset and degree of these abnormalities remain unclear...
  42. ncbi Neocortical RELN promoter methylation increases significantly after puberty
    Carla Lintas
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, IRCCS Fondazione Santa Lucia, Rome, Italy
    Neuroreport 21:114-8. 2010
    ..Sex hormones thus seemingly boost DNA methylation at the RELN promoter. This physiological change could significantly contribute to the onset of schizophrenia and the worsening of autistic behaviors, both typically occurring at puberty.
  43. ncbi Endocrinology of female puberty
    Sara A DiVall
    Division of Pediatric Endocrinology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Curr Opin Endocrinol Diabetes Obes 16:1-4. 2009
    b>Puberty is the developmental process that culminates in reproductive capability...
  44. ncbi Sex steroids and brain structure in pubertal boys and girls
    Jiska S Peper
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    Psychoneuroendocrinology 34:332-42. 2009
    ..Early in life, they are involved in brain sexual differentiation. During puberty, sex steroid levels increase considerably...
  45. ncbi Energy balance and puberty onset: emerging role of central mTOR signaling
    Juan Roa
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    Trends Endocrinol Metab 21:519-28. 2010
    The onset of puberty is gated by body energy reserves and nutritional cues. The adipose hormone leptin is an essential signal for the metabolic control of puberty, through mechanisms that are yet to be fully characterized...
  46. ncbi Changes in sleep as a function of adolescent development
    Ian M Colrain
    Human Sleep Research Program, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94043, USA
    Neuropsychol Rev 21:5-21. 2011
    ....
  47. ncbi Association of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) with age of puberty among children living near a chemical plant
    Maria José Lopez-Espinosa
    Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London WC1H 9SH, United Kingdom
    Environ Sci Technol 45:8160-6. 2011
    ..Relationships of human PFC exposure with puberty are not clear...
  48. pmc Puberty and pubertal growth in healthy Turkish girls: no evidence for secular trend
    Ruveyde Bundak
    Istanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Pediatric Endocrinology Unit, Istanbul, Turkey
    J Clin Res Pediatr Endocrinol 1:8-14. 2008
    ..Assessment of pubertal stages should be related to updated and reliable referance data from the same background population...
  49. ncbi The accrual of bone mass during childhood and puberty
    Mohamed Z Mughal
    Department of Paediatric Endocrinology, Royal Manchester, Children s Hospital, Manchester, UK
    Curr Opin Endocrinol Diabetes Obes 18:28-32. 2011
    ..To assess factors that influence the tempo of bone mass accrual with emphasis on obesity, exercise, and nutritional factors...
  50. pmc Body mass index and waist-to-height changes during teen years in girls are influenced by childhood body mass index
    Frank M Biro
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, Adolescent Medicine ML 4000, Cincinnati, Ohio 45229, USA
    J Adolesc Health 46:245-50. 2010
    ..This study examined longitudinal changes in waist-to-height ratio and components of body mass index (BMI) among young and adolescent girls of black and white race/ethnicity...
  51. pmc Biomarkers for assessing reproductive development and health: Part 1--Pubertal development
    John C Rockett
    Gamete and Early Embryo Biology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Health Perspect 112:105-12. 2004
    ..In this review, we discuss some of the current and emerging biomarkers of human pubertal development...
  52. ncbi Recent changes in pubertal timing in healthy Danish boys: associations with body mass index
    Kaspar Sørensen
    Department of Growth and Reproduction, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 95:263-70. 2010
    In the 1990s, the American population-based study NHANES III renewed the focus on possible secular trends in male puberty. However, no conclusions could be made on pubertal onset due to the lack of compatible data.
  53. ncbi The role of puberty, media and popularity with peers on strategies to increase weight, decrease weight and increase muscle tone among adolescent boys and girls
    Marita P McCabe
    School of Psychology, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia
    J Psychosom Res 52:145-53. 2002
    ..In particular, the study investigated the underresearched area of strategies to increase weight and muscle. The exploration of body change strategies among adolescent boys has been a neglected area of research...
  54. ncbi Bone microstructure at the distal tibia provides a strength advantage to males in late puberty: an HR-pQCT study
    Melonie Burrows
    Department of Orthopaedics, Centre for Hip Health and Mobility, University of British Columbia, British Columbia, Canada
    J Bone Miner Res 25:1423-32. 2010
    ..Males' larger and denser bones confer a bone-strength advantage from a young age compared with females. These structural differences could represent bones that are less able to withstand loads in compression in females...
  55. ncbi It's about timing and change: pubertal transition effects on symptoms of major depression among African American youths
    Xiaojia Ge
    Department of Human and Community Development, University of California, Davis 95616, USA
    Dev Psychol 39:430-9. 2003
    ..Results support the early timing hypothesis for girls and the stressful change hypothesis for boys. Time at assessment is critical when examining boys' pubertal transition...
  56. ncbi A workshop on pubertal hormone replacement options in the United States
    Stephanie Drobac
    Department of Pediatrics, University of Chicago, IL, USA
    J Pediatr Endocrinol Metab 19:55-64. 2006
    ..The optimal pubertal hormone replacement therapy in females and males is unclear...
  57. ncbi Early and late weight gain and the timing of puberty
    David B Dunger
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Cambridge CB2 2QQ, UK
    Mol Cell Endocrinol 254:140-5. 2006
    ..Several longitudinal studies have demonstrated that timing of puberty is most closely linked to infancy weight gain: suggesting an early window for programming of growth and ..
  58. ncbi Serum hormones in boys prenatally exposed to polychlorinated biphenyls and dibenzofurans
    Ping Chi Hsu
    Department of Safety, Health and Environmental Engineering, National Kaohsiung First University of Science and Technology, Kaohsiung, Taiwan
    J Toxicol Environ Health A 68:1447-56. 2005
    ..were not statistically different between Yucheng and control boys in the subgroups of before and at the age of puberty. However, the serum estradiol (E2) levels were significant higher in Yucheng boys at the age of puberty...
  59. ncbi Persistent impact of pubertal timing on trends in smoking, food choice, activity, and stress in adolescence
    Cornelia H M van Jaarsveld
    Cancer Research UK Health Behaviour Unit, Department of Epidemiology and Public Health, University College London, Gower Street, London WC1E 6BT, UK
    Psychosom Med 69:798-806. 2007
    a) To replicate the established association between early puberty and smoking; b) to see whether differences between early and late maturers narrowed with increasing age and differed by gender; and c) to determine whether other health ..
  60. ncbi Sex 'n' drugs 'n' rock 'n' roll: the meaning and social consequences of pubertal timing
    Andrea Waylen
    University of Bristol, Unit of Paediatric and Perinatal Epidemiology, Department of Community Based Medicine, 24 Tyndall Avenue, Bristol, UK
    Eur J Endocrinol 151:U151-9. 2004
    ..changes in adolescent behaviour and the interplay between biology and social factors that occur at and around puberty, in an attempt to explain when this transition may become problematic The onset of puberty is a biological marker ..
  61. ncbi Variation in the timing of puberty: clinical spectrum and genetic investigation
    M R Palmert
    Division of Endocrinology, Department of Medicine, Children's Hospital, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 86:2364-8. 2001
    Human puberty begins with the reemergence of GnRH secretion from its relative quiescence during childhood, activating a cascade of pituitary-gonadal maturation...
  62. pmc Age at puberty and the emerging obesity epidemic
    Lise Aksglaede
    Department of Growth and Reproduction, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e8450. 2009
    Recent studies have shown that puberty starts at younger ages than previously. It has been hypothesized that the increasing prevalence of childhood obesity is contributing to this trend...
  63. pmc Genetic and environmental influences on pubertal timing assessed by height growth
    Karoliina Wehkalampi
    Hospital for Children and Adolescents, Helsinki University Hospital, 00290 Helsinki, Finland
    Am J Hum Biol 20:417-23. 2008
    Secular trends towards earlier puberty, possibly caused by new environmental triggers, provide a basis for periodic evaluation of the influence and interaction of genetic and environmental effects on pubertal timing...
  64. ncbi Endocrine-disrupting compounds and mammary gland development: early exposure and later life consequences
    Suzanne E Fenton
    U S Environmental Protection Agency, ORD, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, MD 67, Research Triangle Park, North Carolina 27711, USA
    Endocrinology 147:S18-24. 2006
    ..compounds (EDCs) are suspected of contributing to increased breast cancer incidence as well as precocious puberty in the United States...
  65. ncbi Gender differences in asthma development and remission during transition through puberty: the TRacking Adolescents' Individual Lives Survey (TRAILS) study
    Nienke M Vink
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Allergy Clin Immunol 126:498-504.e1-6. 2010
    During puberty, a gender shift in asthma prevalence occurs, with a preponderance of boys before puberty. The mechanisms underlying this gender shift are unclear.
  66. ncbi Pubertal assessment method and baseline characteristics in a mixed longitudinal study of girls
    Frank M Biro
    Cincinnati Children s Hospital Medical Center, Adolescent Medicine ML 4000, and Department of Environmental Health, University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Pediatrics 126:e583-90. 2010
    ..The objective of this study was to describe the assessment methods and maturation status for a multisite cohort of girls at baseline recruitment and at ages 7 and 8 years...
  67. ncbi Pubertal transition, stressful life events, and the emergence of gender differences in adolescent depressive symptoms
    X Ge
    Department of Human and Community Development, University of California, Davis 95616, USA
    Dev Psychol 37:404-17. 2001
    ..The findings demonstrate the importance of the interaction between the pubertal transition and psychosocial factors in increasing adolescent vulnerability to depressive experiences...
  68. pmc Genetic variation in LIN28B is associated with the timing of puberty
    Ken K Ong
    Medical Research Council MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 41:729-33. 2009
    The timing of puberty is highly variable. We carried out a genome-wide association study for age at menarche in 4,714 women and report an association in LIN28B on chromosome 6 (rs314276, minor allele frequency (MAF) = 0.33, P = 1...
  69. ncbi Sex differences and the impact of steroid hormones on the developing human brain
    Susanne Neufang
    Institute of Neuroscience and Biophysics, Research Center Juelich, D 52425 Juelich, Germany
    Cereb Cortex 19:464-73. 2009
    Little is known about the hormonal effects of puberty on the anatomy of the developing human brain. In a voxel-based morphometry study, sex-related differences in gray matter (GM) volume were examined in 46 subjects aged 8-15 years...
  70. ncbi Puberty and body composition
    Roger M Siervogel
    Department of Community Health, Wright State University School of Medicine, Dayton, OH 45420, USA
    Horm Res 60:36-45. 2003
    Body composition during puberty is a marker of metabolic changes that occur during this period of growth and maturation, and, thus, holds key information regarding current and future health...
  71. ncbi Public health implications of altered puberty timing
    Mari S Golub
    Department of Environmental Toxicology, University of California, Davis, California, USA
    Pediatrics 121:S218-30. 2008
    Changes in puberty timing have implications for the treatment of individual children, for the risk of later adult disease, and for chemical testing and risk assessment for the population...
  72. pmc Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girls
    Mary S Wolff
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Environ Health Perspect 118:1039-46. 2010
    ..Hormonally active environmental agents may alter the course of pubertal development in girls, which is controlled by steroids and gonadotropins...
  73. ncbi Puberty and the emergence of gender differences in psychopathology
    Chris Hayward
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305, USA
    J Adolesc Health 30:49-58. 2002
  74. ncbi Sensation seeking, puberty, and nicotine, alcohol, and marijuana use in adolescence
    Catherine A Martin
    Department of Psychiatry, Behavioral Science, and Pediatrics, University of Kentucky College of Medicine, Lexington 40509, USA
    J Am Acad Child Adolesc Psychiatry 41:1495-502. 2002
    ..To examine the relationship among nicotine, alcohol, and marijuana use; level of sensation seeking (SS); and pubertal development...
  75. ncbi Genetics basis for GnRH-dependent pubertal disorders in humans
    Leticia Ferreira Gontijo Silveira
    Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42 da Disciplina de Endocrinologia do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
    Mol Cell Endocrinol 324:30-8. 2010
    Human puberty is triggered by the reemergence of GnRH pulsatile secretion, with progressive activation of gonadal function. Several mutations have been identified in an increasing number of genes that influence the onset of puberty...
  76. ncbi Precocious puberty and statural growth
    Jean Claude Carel
    Groupe Hospitalier Cochin Saint Vincent De Paul, Faculté Cochin Université Paris V and INSERM U561, Paris
    Hum Reprod Update 10:135-47. 2004
    Precocious puberty results mostly from the precocious activation of the gonadotropic axis...
  77. ncbi Clinical utility of measurement of anti-mullerian hormone in reproductive endocrinology
    William L Ledger
    University of Sheffield, Academic Unit of Reproductive and Developmental Medicine, Jessop Wing, Royal Hallamshire Hospital, Sheffield S10 2SF, United Kingdom
    J Clin Endocrinol Metab 95:5144-54. 2010
    ....
  78. ncbi Diagnostic work-up of 449 consecutive girls who were referred to be evaluated for precocious puberty
    Signe Sloth Mogensen
    Department of Growth and Reproduction, Rigshospitalet, University Hospital of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 96:1393-401. 2011
    ..The aim of this study was to describe a large cohort of Caucasian girls referred with signs of early puberty according to etiology and compare biochemical characteristics.
  79. ncbi Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty, and follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol levels
    A M Andersson
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 82:3976-81. 1997
    ..levels of inhibin B, FSH, LH, testosterone, and estradiol all increased significantly between stages I and II of puberty. From stage II of puberty the inhibin B level was relatively constant, whereas the FSH level continued to ..
  80. ncbi Minireview: the neuroendocrine regulation of puberty: is the time ripe for a systems biology approach?
    Sergio R Ojeda
    Division of Neuroscience, Oregon National Primate Research Center Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, Oregon 97006, USA
    Endocrinology 147:1166-74. 2006
    The initiation of mammalian puberty requires an increase in pulsatile release of GnRH from the hypothalamus. This increase is brought about by coordinated changes in transsynaptic and glial-neuronal communication...
  81. ncbi A leptin missense mutation associated with hypogonadism and morbid obesity
    A Strobel
    Nat Genet 18:213-5. 1998
  82. ncbi Stress and the adolescent brain
    Russell D Romeo
    Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, New York, NY 10021, USA
    Ann N Y Acad Sci 1094:202-14. 2006
    ....
  83. pmc Gene networks and the neuroendocrine regulation of puberty
    Sergio R Ojeda
    Division of Neuroscience, Oregon National Primate Research Center Oregon, Health and Science University, 505 N W 185th Avenue, Beaverton, OR, USA
    Mol Cell Endocrinol 324:3-11. 2010
    ..hormone (GnRH) from the hypothalamus is an essential, final event that defines the initiation of mammalian puberty. This increase depends on coordinated changes in transsynaptic and glial-neuronal communication, consisting of ..
  84. ncbi Puberty and depression
    Adrian Angold
    Department of Psychiatry and Behavioral Sciences, Center for Developmental Epidemiology, Duke University Medical Center, Brightleaf Square, Suite 22, 905 West Main Street, Durham, NC 27701, USA
    Child Adolesc Psychiatr Clin N Am 15:919-37, ix. 2006
    ..and timing have been implicated, but few studies have deployed either the measurement strategies or the statistical power needed to provide a satisfactory answer to the question regarding which components of puberty are most responsible.
  85. ncbi Impaired endothelial and smooth muscle functions and arterial stiffness appear before puberty in obese children and are associated with elevated ambulatory blood pressure
    Yacine Aggoun
    Paediatric Cardiology Unit, Department of Child and Adolescent, University Hospitals of Geneva, 6, rue Willy Donze, 1211 Geneva 14, Switzerland
    Eur Heart J 29:792-9. 2008
    ..whether impaired brachial endothelial (flow-mediated dilation, FMD) and smooth muscle function (nitroglycerin-mediated dilation, NTGMD), and remodelling of the common carotid artery (CCA) develop before puberty in obese children.
  86. ncbi Association of prepubertal body composition in healthy girls and boys with the timing of early and late pubertal markers
    Anette E Buyken
    Research Institute of Child Nutrition, affiliated with the Rheinische Friedrich Wilhelms Universität, Bonn, Dortmund, Germany
    Am J Clin Nutr 89:221-30. 2009
    It is controversial whether prepubertal body composition is implicated in the timing of puberty onset.
  87. ncbi Management of the child born small for gestational age through to adulthood: a consensus statement of the International Societies of Pediatric Endocrinology and the Growth Hormone Research Society
    P E Clayton
    University of Manchester, Manchester M13 9PL, United Kingdom
    J Clin Endocrinol Metab 92:804-10. 2007
    ..A meeting was convened to identify the key health issues facing a child born small for gestational age (SGA) and to propose management strategies...
  88. pmc Healthy adolescents' neural response to reward: associations with puberty, positive affect, and depressive symptoms
    Erika E Forbes
    University of Pittsburgh, USA
    J Am Acad Child Adolesc Psychiatry 49:162-72.e1-5. 2010
    ..developmental change in the reactivity of the striatum and medial prefrontal cortex (mPFC) and have not considered puberty. The current study focused on puberty-specific changes in brain function and their association with mood.
  89. ncbi Prevalence and concomitants of glucose intolerance in European obese children and adolescents
    Cecilia Invitti
    Department of Metabolic Diseases and Diabetes, Istituto Auxologico Italiano, Milan, Italy
    Diabetes Care 26:118-24. 2003
    ..The prevalence of glucose intolerance and its determinants and the relation of cardiovascular risk factors with levels of glycemia and degree of obesity were studied in grossly obese children of European origin...
  90. ncbi Pubertal timing is an independent predictor of central adiposity in young adult males: the Gothenburg osteoporosis and obesity determinants study
    Jenny M Kindblom
    Bone Research Center at the Institute of Medicine, Sahlgrenska Universitetssjukhuset Sahlgrenska, Grona Straket 8, 413 45 Gothenburg, Sweden
    Diabetes 55:3047-52. 2006
    The role of puberty and normal variations in pubertal timing for the development of obesity in men is unclear...
  91. ncbi Endocrine disrupters and female reproductive health
    John A McLachlan
    Department of Pharmacology, Tulane University School of Medicine, and Environmental Endocrinology Laboratory, Center for Bioenvironmental Research, Tulane and Xavier Universities, New Orleans, LA 70118, USA
    Best Pract Res Clin Endocrinol Metab 20:63-75. 2006
    ..Estrogen is the key hormone in the initiation (puberty) and the end (menopause) of reproductive life in women and thus of considerable importance in women's health...
  92. pmc Association of blood lead levels with onset of puberty in Russian boys
    Russ Hauser
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Environ Health Perspect 116:976-80. 2008
    Epidemiologic studies suggest a temporal trend of earlier onset and longer duration of puberty, raising concerns regarding the potential impact of environmental factors on pubertal development...
  93. ncbi Gender differences of oligomers and total adiponectin during puberty: a cross-sectional study of 859 Danish school children
    Kristian Kjaer Andersen
    The Medical Research Laboratories, Clinical Institute, Medical Department M Diabetes and Endocrinology, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 92:1857-62. 2007
    ..Pubertal stages have been shown to influence total adiponectin (ADPN) levels. Furthermore, testosterone has been shown to alter the isomer distribution of ADPN...
  94. ncbi Thelarche, pubarche, and menarche attainment in children with normal and elevated body mass index
    Robert L Rosenfield
    Department of aPediatrics, University of Chicago, Chicago, IL, USA
    Pediatrics 123:84-8. 2009
    The early onset of puberty may be related to obesity, so there is a need to know the prevalence of early pubertal milestones in nonoverweight children. OBJECTIVE...
  95. pmc Forty years trends in timing of pubertal growth spurt in 157,000 Danish school children
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 3:e2728. 2008
    Entering puberty is an important milestone in reproductive life and secular changes in the timing of puberty may be an important indicator of the general reproductive health in a population...
  96. ncbi Breastfeeding, childhood milk consumption, and onset of puberty
    Man Ki Kwok
    Life course and Lifestyle Epidemiology Group, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Pediatrics 130:e631-9. 2012
    ..Limited observational studies, mainly from Western settings, suggest puberty occurs later with breastfeeding and earlier with higher cow's milk (including infant formula) consumption...
  97. ncbi Sex differences in bone size and bone mineral density exist before puberty. The Copenhagen School Child Intervention Study (CoSCIS)
    H Hasselstrøm
    Institute for Exercise and Sport Sciences, University of Copenhagen, Nørre Allé 51, DK 2200 Copenhagen N, Denmark
    Calcif Tissue Int 79:7-14. 2006
    ....
  98. ncbi The physiology and timing of male puberty
    Jeanette Tinggaard
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Denmark
    Curr Opin Endocrinol Diabetes Obes 19:197-203. 2012
    To describe available markers of male puberty, discuss associations between adiposity and pubertal timing and to review recent evidence of a possible secular trend in male pubertal timing.
  99. pmc Testosterone production during puberty in two 46,XY patients with disorders of sex development and novel NR5A1 (SF-1) mutations
    Sally Tantawy
    Department of Pediatric Endocrinology, University Children s Hospital, Charite, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Endocrinol 167:125-30. 2012
    ..Further, Sertoli cell dysfunction is seen (low inhibin B, anti-Müllerian hormone). However, gonadal function at puberty in patients with NR5A1 mutations is unknown.
  100. ncbi Targeted toxicological testing to investigate the role of endocrine disrupters in puberty disorders
    Francesca Maranghi
    Food and Veterinary Toxicology Unit, Dept Food Safety and Veterinary Public Health, Istituto Superiore di Sanita, Viale Regina Elena, 299 00161 Rome, Italy
    Reprod Toxicol 33:290-6. 2012
    b>Puberty is a process regulated by the endocrine system which physiological onset is poorly understood. Factors potentially leading to the disruption of this system may seriously affect the reproductive function development...
  101. pmc Patterns of linear growth and skeletal maturation from birth to 18 years of age in overweight young adults
    W Johnson
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
    Int J Obes (Lond) 36:535-41. 2012
    ..To estimate differences in skeletal maturity and stature from birth to age 18 years between individuals who are overweight vs normal weight in young adulthood...

Research Grants75

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Effects of Testosterone and Genetic Factors on Psychological and Motor Function i
    NICOLE RENEE TARTAGLIA; Fiscal Year: 2013
    ..We hypothesize that testosterone therapy initiated in early puberty in KS/XXY will lead to improvements in executive function, psychosocial functioning, and motor skills, while ..
  3. Structure and function of urea transporters
    Ming Zhou; Fiscal Year: 2013
    ..Mice with urea transporters knocked out showed progressive heart block and early puberty, in addition to defects in concentrating urine...
  4. Neural Functioning of Feeding Centers in Obese Youth
    ROBERT STANLEY SHERWIN; Fiscal Year: 2013
    ..with insulin resistance, relative low levels of leptin and marked hyperinsulinemia compared to age, gender and puberty matched obese sensitive and lean adolescents...
  5. Transgenerational effects of endocrine disruptors: epigenetics and physiology
    Rebecca A Simmons; Fiscal Year: 2013
    ..Specific Aim 2 will ascertain whether BPA exposure of males during puberty and early adulthood alters the germline and leads to transgenerational transmission of an altered epigenotype and ..
  6. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..We have found that re-expression of LepR selectively in the ventral premammillary nucleus (PMV) induce puberty, sexual maturation and improve fertility...
  7. Epigenetic effects of developmental endocrine disruptor exposure in the ovary
    Mehmet Uzumcu; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Female reproductive disorders, including precocious puberty, irregular menstrual cycles, and reduced fertility, are increasing among certain human populations...
  8. Transcriptional control of pituitary gonadotropin genes
    Varykina G Thackray; Fiscal Year: 2013
    ..a range of disorders that can result from malfunction in gonadotropin production, such as amenorrhea, precocious puberty, ideopathic hypogonadism, and polycystic ovarian syndrome...
  9. Vitamin D3 Regulation of the Hypothalamic-Pituitary-Gonadal Axis
    Genevieve S Neal-Perry; Fiscal Year: 2012
    ..Our preliminary data show that gonadotropins stimulate follicular development and ovulation, but that puberty and the first estrus are delayed in vitamin D3 deficient CYP27b1 null female mice and that null mice have altered ..
  10. Parenting, Adolescent Self-Regulation, and Risk-Taking Across Cultures
    Jennifer E Lansford; Fiscal Year: 2013
    ..aims to understand how risk-taking develops across adolescence as a function of biological maturation (puberty and age) and socialization (parenting and culture)...
  11. GENETICS OF DELAYED PUBERTY
    Lawrence C Layman; Fiscal Year: 2013
    ..We hope to understand how mutations in two genes (CHD7 and NELF) disrupt puberty and cause infertility in humans...
  12. Progression of Autoimmunity During Puberty in SLE
    KATHLEEN M O'NEIL; Fiscal Year: 2011
    ..whom to address this essential clue to autoimmunity, children with autoimmune disease who are progressing through puberty, has not been available in sufficient numbers for study...
  13. Progesterone's Role in Pubertal Maturation in Normal and Hyperandrogenemic Adoles
    JESSICAH S P COLLINS; Fiscal Year: 2011
    ..maturation in normal and HA adolescent girls in order to improve our understanding of normal and aberrant puberty. In doing so, this research may help guide future treatment-and perhaps prevention-of PCOS before its full ..
  14. Effect of bisphenol A exposure on mammary stem cell function and transformation
    Luzhe Sun; Fiscal Year: 2013
    ..The murine mammary stem cells (MaSCs) have the potential to drive mammary gland development during puberty, and growth and remodeling during pregnancy...
  15. Calcium Signaling in the Pubertal Activation of the GnRH Pulse Generator
    Daniel J Spergel; Fiscal Year: 2011
    ..well as treatments for infertility and the pubertal disorders polycystic ovary syndrome, hypogonadism, precocious puberty, and delayed puberty, which possibly result from an abnormal increase in GnRH secretion...
  16. Dioxins and Male Pubertal Growth and Development
    Russ B Hauser; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Puberty is the dynamic physical, behavioral, and hormonal transition from the pre-pubertal state to sexual maturity and adult reproductive capacity...
  17. STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging - RESUBM
    Sioban D Harlow; Fiscal Year: 2011
    ..It has become the gold standard for characterizing reproductive aging, as the Tanner Stages characterize puberty. In the past decade, understanding of the critical junctures in hypothalamic and ovarian function before and ..
  18. Developmental Origins of Phenotypic Characteristics that Predict Longevity
    Andrzej Bartke; Fiscal Year: 2012
    ..findings indicate that the actions of GH early in life (starting before weaning and continuing to the age of puberty) influence life expectancy...
  19. The relative roled of sex and genes during development of systemic autoimmunity
    TRINE NORGAARD JORGENSEN; Fiscal Year: 2010
    ..we can segregate the effects of genes and hormones on the immune system in vivo we have found that even before puberty female bone marrow cells express an intrinsic capacity to drive accelerated lupus-like disease development in a ..
  20. ANALYSIS OF CHROMATIN REMODELING IN MAMMARY GLAND DEVELOPMENT USING TILING ARRAYS
    Monique Rijnkels; Fiscal Year: 2009
    ..Because the mammary gland develops mostly postnatally and the hormones of puberty and pregnancy tightly regulate its tissue specific gene expression, it makes an excellent model system to study ..
  21. Delayed pubertal development on the mechanism of bone loss at maturity
    Vanessa R Yingling; Fiscal Year: 2011
    ..A delay in the onset of puberty (primary amenorrhea) correlates with both low bone mass;4. and an increased incidence of stress fracture...
  22. A PANHYPOPITUITARY MOUSE MUTATION
    Sally A Camper; Fiscal Year: 2013
    ..Gain of function alleles cause transient hypogonadism, delayed puberty, and increased risk of pituitary adenomas, the most common type of intracranial tumor in humans...
  23. Identification of stromal responses during castration-induced thymic regrowth.
    Howard T Petrie; Fiscal Year: 2013
    ..the size of the thymus degenerates progressively with age, with a noticeable onset at around the time of puberty. Because the output of new T cells from the thymus is directly proportional to its mass, age-related thymic ..
  24. Sleep Disordered Breathing and Growth in Children: A Longitudinal Cohort Study
    Karen Bonuck; Fiscal Year: 2009
    ..of SDB symptoms, and;b) delineate trends in the natural and treatment history of SDB from infancy through pre-puberty. 2) To Determine the Association Between SDB Symptoms &Growth We will assess: a) whether the prevalence, ..
  25. Sex chromosome aneuploidies in autoimmune disease
    R Hal Scofield; Fiscal Year: 2013
    ..The sex bias of the disease is present in patients with onset before puberty as well as at older ages after menopause...
  26. Bisphenol A and Children's Growth & Development
    KIM G contact HARLEY; Fiscal Year: 2010
    ..including sexually-dimorphic alterations in brain structure and behavior;increased weight gain;and earlier puberty. Because of these health concerns, several countries and U.S. states are considering legislation to ban BPA...
  27. Changes in Adipokines and Adiposity during Puberty and Young Adulthood
    NICOLE LENORE MIHALOPOULOS; Fiscal Year: 2013
    ..determine whether serum concentrations of adiponectin and leptin are associated with metabolic dysfunction during puberty among obese and normal weight children and adolescents. This aim includes two longitudinal studies...
  28. The Significance of Leptin Signals to Neonatal Somatotropes and Gonadotropes
    Gwen V Childs; Fiscal Year: 2013
    ..sets of studies will also investigate the role of leptin in the postnatal development of lactotropes, timing of puberty, fertility, development of the reproductive organs, and somatotrope or gonadotrope responses to gonadal steroids...
  29. Integration of PR and FoxO Signaling in Pituitary Gonadotropes
    Varykina G Thackray; Fiscal Year: 2010
    ..to new directions in treating a range of physiological disorders that can result from malfunction in gonadotropin production such as amenorrhea, precocious puberty, ideopathic hypogonadism, polycystic ovarian syndrome and infertility.
  30. The Kiss1 system in the neuroendocrine control of reproduction
    VICTOR MANUEL NAVARRO; Fiscal Year: 2013
    ..Kiss1 expression in these neurons increases at the time of puberty onset and humans and rodents bearing inactivating mutations in this gene or its receptor (Kiss1r) exhibit ..
  31. The Effects of Estradiol on Genetic Risk for Disordered Eating During Puberty
    Kelly L Klump; Fiscal Year: 2013
    ..They display a stereotypic pattern of development in girls with significant increases in prevalence only after puberty. Theories accounting for this pubertal risk have focused almost entirely on psychosocial risk factors that ..
  32. NEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUS
    Pamela L Mellon; Fiscal Year: 2013
    ..This discrete population of ~800 neurons, scattered through the hypothalamus, controls puberty, menstrual cyclicity, fertility, and meno- pause...
  33. Identification of Stromal Responses During Castration Mediated Thymic Regrowth
    ANN VENABLES GRIFFITH; Fiscal Year: 2011
    ..However, the thymus degenerates with age, beginning around puberty. Because output of new T cells from the thymus is proportional to its mass, age-related thymic atrophy results in ..
  34. HORMONAL INFLUENCES ON AIRWAY DISEASE
    Raksha Jain; Fiscal Year: 2013
    ..registry to retrospectively compare lung function and pulmonary exacerbations in men and women pre- and post-puberty and recruit CF bronchiectasis women locally to prospectively assess lung health during hormonal phases of the ..
  35. NEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUS
    Pamela L Mellon; Fiscal Year: 2011
    ..It controls puberty, the menstrual cycle, fertility, menopause, and when disregulated, causes infertility...
  36. THE TEMPORAL AND SPATIAL REGULATION OF BONE ACQUISITION BY SERUM IGF-1
    Shoshana Yakar; Fiscal Year: 2012
    ..Thus two major aims are proposed: 1-Determine the effect of serum IGF-I depletion during early growth, puberty, and post puberty (2,4,8, and 12 weeks) on peak bone acquisition...
  37. Growth and Carcinogenic Potential in the Postnatal Mammary Gland
    Demetri D Spyropoulos; Fiscal Year: 2010
    ..by applicant): Mammary development occurs in two distinct phases, an initial phase of modest growth (embryonic to puberty) and a later phase of robust expansion...
  38. Epidemiology of asthma: risk and prognosis in a cohort from birth to adolescence
    Syed Hasan Arshad; Fiscal Year: 2010
    ..S. children and is more prevalent in boys throughout childhood;however, during puberty a gender reversal occurs...
  39. Using Genetics For Early Phenotyping &Prevention of Hypertrophic Cardiomyopathy
    Christine E Seidman; Fiscal Year: 2013
    ..clinical feature of HCM, is a relatively late manifestation of disease and typically emerges around the time of puberty. In contrast, gene-based diagnosis identifies not only individuals who carry pathogenic mutations (G+) and have ..
  40. Effects of Lactational Exposure to Chromium (VI) on Ovarian Development
    SAKHILA BANU; Fiscal Year: 2010
    ..Toxic effects resulting from lactational exposure to Cr(VI) on ovarian follicular development, puberty, and reproductive health of developing offspring remain an enigma, and the principal cellular and molecular ..
  41. Neuroendocrine regulation of the reproductive axis during puberty and development
    Alexander S Kauffman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In mammals, including humans, puberty onset reflects the activation of the neuroendocrine reproductive axis, and adolescence is therefore a time of key physiological, anatomical, behavioral, and ..
  42. CHILDHOOD DIOXIN EXPOSURE AND ENERGY HOMEOSTASIS DYSREGULATION
    Jane S Burns; Fiscal Year: 2010
    ..of this study in which the boys, enrolled at 8 to 9 years old, are evaluated yearly, and will be followed through puberty to adulthood...
  43. Control of Nociception in the Spinal Cord
    Sukhbir S Mokha; Fiscal Year: 2013
    ..and a new perspective in the treatment of pain, particularly in women at different phases of their life (pre-puberty, reproductive years, pregnancy, and menopause) and aging men...
  44. Oxidative stress and schizophrenia: combination of cell biology and brain imaging
    Akira Sawa; Fiscal Year: 2013
    ..provided by applicant): Schizophrenia (SZ) is a debilitating mental illness typically developing after puberty. Accumulating evidence suggests role for disturbances in postnatal brain maturation, which includes interneuron ..
  45. Interactions of MAO A with vulnerability factors for aggression
    Marco Bortolato; Fiscal Year: 2012
    ..In males, the increase in testosterone levels at puberty interacts with these changes, resulting in imbalances in steroids and monoamines in prefrontal cortex and other ..
  46. Neural basis of leptin action on reproduction
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..However, whether Kiss1 or PMV neurons relay leptin's effect on puberty initiation and coordinated reproductive control has not been directly test...
  47. Insulin and IGF-1 regulation of the GnR H neuron
    Sara A DiVall; Fiscal Year: 2012
    ..pathways with the insulin receptor, increases GnRH expression in vitro, and in vivo plays a permissive role in puberty onset...
  48. Prenatal exposure to high-fat diets promotes alcohol preference in the offspring
    Miriam E Bocarsly; Fiscal Year: 2012
    ..that the rats have, more galanin cells due to in utero programming, more galanin expression due to hormones at puberty and more galanin expression when they start drinking. Exp...
  49. Intragenic Suppressors of McCune-Albright Syndrome Mutations
    ROBIN PALS RYLAARSDAM; Fiscal Year: 2010
    ..MAS) is a genetic syndrome classically defined by the triad of fibrous dysplasia of the bone, precocious puberty, and cafi-au-lait skin hyperpigentation, often accompanied by other disorders of a hyperfunctioning endocrine ..
  50. Bisphenol-A and Reproductive Dysfunction
    Vasantha Padmanabhan; Fiscal Year: 2013
    ..sensitive cancers, decline in human sperm quality and quantity, a notable rise in endometriosis, and early puberty in women...
  51. The interaction between sleep and reproductive hormone secretion during puberty
    NATALIE DARA SHAW; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): At the time of puberty, the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator reawakens, stimulating pituitary secretion of luteinizing hormone (LH) and follicle stimulating hormone (..
  52. PHYSIOLOGICAL DISSECTION OF THE SCN
    Rae Silver; Fiscal Year: 2010
    ..The work also contributes to a better understanding of circadian changes associated with puberty, andropause, sleep regulation and some aspects of sex differences.
  53. Mitochondrial Determinants of Metabolic Disease in HIV-Infected Children
    Tracie L Miller; Fiscal Year: 2013
    ..100 HIV (-) in PHACS and among the HIV (+) children, to determine clinical characteristics (metabolic, age, sex, puberty, viral load, antiretroviral therapy) associated with mitochondrial dysfunction;2...
  54. Black carbon exposure, DNA methylation, airway inflammation in pediatric asthma
    Rachel L Miller; Fiscal Year: 2013
    ..BC exposure, BC exposure over the last 6 and 12 months, early residential indoor allergen levels, sex, age, early puberty (via Tanner stage), ethnicity...
  55. Etiology of breast development in the BCERC network: role of socioeconomic status
    DEJANA K BRAITHWAITE; Fiscal Year: 2010
    ..We hypothesize that social and economic factors may reflect upstream determinants of early puberty. In the network of three prospective multiethnic cohorts of girls (n=1,238) aged 6 to 8 years at baseline and ..
  56. Pubertal hyperandrogenemia, modification of day-night GnRH secretion, and PCOS
    Christopher R McCartney; Fiscal Year: 2012
    ..Nocturnal GnRH frequency does not change significantly from early to late puberty, whereas daytime frequency demonstrates a marked increase...
  57. STRESS AND REPRODUCTIVE HORMONES IN DEPRESSION
    Jon Kar Zubieta; Fiscal Year: 2012
    ..provided by applicant): The onset of sex bias in the expression of depressive illness after the onset of puberty, as well as anecdotal studies suggesting an association between mood and cyclic gonadal steroid changes suggest ..
  58. BISPHENOL A LEVELS and ENDOMETRIOSIS RISK IN REPRODUCTIVE-AGE WOMEN
    Victoria L Holt; Fiscal Year: 2012
    ..We further hypothesize that given the dynamic cyclic changes in endometrial tissue, the years from puberty to menopause are a critical period of susceptibility for exposure to BPA in relation to this disease...
  59. Mechanisms underlying sexually differentiated brain remodeling during adolescence
    Cheryl L Sisk; Fiscal Year: 2013
    ..overturn this view by providing evidence in rats for active maintenance of sexual dimorphisms during puberty via active and hormonally modulated cell addition in sexually differentiated cell groups during puberty...
  60. Urinary peptide excretion and onset of puberty
    Stephen Barnes; Fiscal Year: 2009
    ..goal of this project is to utilize a proteomics approach to define the timing and stages of the onset of puberty. The study will utilize urine and blood samples collected previously from girls between the ages of 10-13 in an ..
  61. Axon, Testosterone and Mental Health during Adolescence
    Tomas Paus; Fiscal Year: 2013
    ..The timing &dynamics of sexual maturation will be indexed by the age of puberty onset and changes in testosterone levels throughout adolescence, i.e...
  62. Metabolic Consequences of Substance Use in Adolescent Girls
    LORAH DENISE DORN; Fiscal Year: 2010
    ..Adolescence is a dynamic period for bone mass development as nearly 50% of mass is accrued primarily around puberty. Smoking, alcohol, &depression can negatively influence bone mass...
  63. GENETICS OF DELAYED PUBERTY
    LAWRENCE LAYMAN; Fiscal Year: 2001
    ..upon the types of mutations characterized, molecular diagnosis might be possible for children with delayed puberty. Female and male humans with idiopathic hypogonadotropic hypogonadism (IHH) typically present with delayed ..
  64. NEUROBIOLOGY OF PUBERTY
    HELEN I ANSON; Fiscal Year: 1993
    ..is to understand the mechanisms whereby growth- related cues influence the rate of sexual maturation and onset of puberty. Specifically, to determine the neurotransmitter pathways which transduce the signal from growth-related cues to ..
  65. ALTERATIONS IN BODY COMPOSITION AND GROWTH AT PUBERTY
    Alan Rogol; Fiscal Year: 1999
    ..Girts with precocious puberty (n=8) on GnRH analogue therapy for at least one year provide a model for pubertal growth, with accompanying high ..
  66. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2005
    ..Overall hypothesis: Androgen synthesis that accompanies puberty contributes to the development of diabetic nephropathy via changes in the renal transforming growth factor (TGF(3)..
  67. PINEAL FUNCTION IN CHILDHOOD AND ADOLESCENCE
    Anita Cavallo; Fiscal Year: 1990
    In spite of numerous studies, the role of the pineal gland in human puberty remains unsettled...
  68. Puberty, Immunity and Malnutrition in S. Japonicum
    Jonathan Kurtis; Fiscal Year: 2005
    DESCRIPTION: The overall objective of this proposal is to prospectively investigate the interrelationships among puberty, protective immune responses, and nutritional status in adolescent Philippine residents of Schistosoma japonicum ..
  69. Calcium Absorption and Bone Formation During Puberty
    Steven Abrams; Fiscal Year: 2005
    ..in bone mass occur during Liberty Optimizing calcium absorption (Ca abs) and bone calcium deposition (V0+) during puberty can enhance peak bone mass and ultimately decrease the lifetime risk of osteoporosis...
  70. Interactive effects of ethanol and estrogen on brain vasopressin during puberty
    Toni R Pak; Fiscal Year: 2010
    ..Little is known about the long-term neurobiological consequences of alcohol consumption during puberty, which is a dynamic and important period of brain development that involves changes in cortical gray matter, ..
  71. Prenatal Testosterone and Risk for Disordered Eating During Puberty
    KRISTEN CULBERT; Fiscal Year: 2009
    ..Elevated prenatal testosterone decreases sensitivity to ovarian hormones during and after puberty in animals...
  72. ANDROGEN EFFECTS ON COGNITION IN TURNER SYNDROME
    Judith Ross; Fiscal Year: 2007
    ..Cognitive and behavioral changes occur during puberty, in concert with marked increases in sex hormone (estrogen and androgen) levels in females and males...
  73. Genotype /phenotype correlations in infertility
    LAWRENCE LAYMAN; Fiscal Year: 2006
    ..affects 10-15% of all individuals attempting to have children, little is known about the molecular basis of human puberty and fertility...
  74. The Role of GPR54 Signaling in Pubertal Disorders
    SUZY DRUMOND CARVALHO BIANCO; Fiscal Year: 2010
    ..Inactivating mutations in GPR54 cause failure to undergo puberty and infertility. In contrast, early stimulation of this receptor triggers precocious puberty in mice...
  75. NEUROENDOCRINOLOGY OF PUBERTY
    Douglas Foster; Fiscal Year: 2004
    When nourishment is inadequate or energy expenditure is great, fertility is reduced in the adult, and puberty is delayed in the developing individual. This suppression of reproductive activity is not understood mechanistically...