premenopause

Summary

Summary: The period before MENOPAUSE. In premenopausal women, the climacteric transition from full sexual maturity to cessation of ovarian cycle takes place between the age of late thirty and early fifty.

Top Publications

  1. ncbi Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk
    P A van den Brandt
    Department of Epidemiology, Maastricht University, The Netherlands
    Am J Epidemiol 152:514-27. 2000
  2. ncbi Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year
    Patrizia Ziccardi
    Department of Geriatrics and Metabolic Diseases, Chair of Metabolic Diseases, Second University of Naples, Italy
    Circulation 105:804-9. 2002
  3. ncbi Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients
    Caroline Holm
    Division of Pathology, Department of Laboratory Medicine, Lund University, Malmo, Sweden
    J Natl Cancer Inst 98:671-80. 2006
  4. ncbi Longitudinal study on the role of body size in premenopausal breast cancer
    Karin B Michels
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 166:2395-402. 2006
  5. ncbi Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer And Nutrition (EPIC)
    Petra H Lahmann
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
    Int J Cancer 111:762-71. 2004
  6. ncbi Intakes of calcium and vitamin D and breast cancer risk in women
    Jennifer Lin
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Arch Intern Med 167:1050-9. 2007
  7. pmc Reproducibility of plasma and urine biomarkers among premenopausal and postmenopausal women from the Nurses' Health Studies
    Joanne Kotsopoulos
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:938-46. 2010
  8. ncbi Insulin-like growth factor-I, IGF-binding protein-3, and mammographic breast density
    Caroline Diorio
    Unité de recherche en santé des populations, Centre Hospitalier Affilie Universitaire De Quebec, Hôpital Saint Sacrement, 1050 Chemin Sainte Foy, Quebec, Quebec, Canada G1S 4L8
    Cancer Epidemiol Biomarkers Prev 14:1065-73. 2005
  9. pmc Obstetric history and mammographic density: a population-based cross-sectional study in Spain (DDM-Spain)
    Virginia Lope
    Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, Monforte de Lemos 5, 28029 Madrid, Spain
    Breast Cancer Res Treat 132:1137-46. 2012
  10. pmc Pathology parameters and adjuvant tamoxifen response in a randomised premenopausal breast cancer trial
    K Jirstrom
    Division of Pathology Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE 205 02, Malmo, Sweden
    J Clin Pathol 58:1135-42. 2005

Research Grants

  1. Neurobiology of the Menopausal Transition
    Yolanda R Smith; Fiscal Year: 2010
  2. Hot flashes and memory dysfunction in the perimenopause
    MIRIAM T WEBER; Fiscal Year: 2013
  3. Inflammatory Markers in a 2-Year Soy Intervention among Premenopausal Women
    Gertraud Maskarinec; Fiscal Year: 2008
  4. Breast Density, IGF-I, & Prolactin, in Four Populations
    Gertraud Maskarinec; Fiscal Year: 2004
  5. Soy Consumption and Breast Tissue Proliferation
    Gertraud Maskarinec; Fiscal Year: 2006
  6. Effects of Soy on Estrogens in Breast Fluid and Urine
    Gertraud Maskarinec; Fiscal Year: 2010
  7. NESTED CASE CONTROL STUDY OF MAMMOGRAPHIC DENSITY
    Gertraud Maskarinec; Fiscal Year: 2002
  8. Nutritional Risk Factors for Type 2 Diabetes in the Multiethnic Cohort
    Gertraud Maskarinec; Fiscal Year: 2008
  9. Estrogen, Metabolism, Menopause, and Health Outcomes
    MaryFran Sowers; Fiscal Year: 2006
  10. Functional Status and the Menopause Transition
    MaryFran R Sowers; Fiscal Year: 2010

Detail Information

Publications268 found, 100 shown here

  1. ncbi Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk
    P A van den Brandt
    Department of Epidemiology, Maastricht University, The Netherlands
    Am J Epidemiol 152:514-27. 2000
    ..The association between BMI and breast cancer varies by menopausal status. Weight control may reduce the risk among postmenopausal women...
  2. ncbi Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year
    Patrizia Ziccardi
    Department of Geriatrics and Metabolic Diseases, Chair of Metabolic Diseases, Second University of Naples, Italy
    Circulation 105:804-9. 2002
    ..Visceral fat is a key regulator site for the process of inflammation, and atherosclerotic lesions are essentially an inflammatory response...
  3. ncbi Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients
    Caroline Holm
    Division of Pathology, Department of Laboratory Medicine, Lund University, Malmo, Sweden
    J Natl Cancer Inst 98:671-80. 2006
    ..Here we studied associations between Pak1 expression and subcellular localization in tumor cells and tamoxifen resistance...
  4. ncbi Longitudinal study on the role of body size in premenopausal breast cancer
    Karin B Michels
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 166:2395-402. 2006
    ..A high body mass index (BMI) has been related to a reduced risk of breast cancer in premenopausal women. The mechanisms underlying this association have not been elucidated...
  5. ncbi Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer And Nutrition (EPIC)
    Petra H Lahmann
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
    Int J Cancer 111:762-71. 2004
    ..Among premenopausal women, weight and BMI showed nonsignificant inverse associations with breast cancer...
  6. ncbi Intakes of calcium and vitamin D and breast cancer risk in women
    Jennifer Lin
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Arch Intern Med 167:1050-9. 2007
    ..Animal data suggest the potential anticarcinogenic effects of calcium and vitamin D on breast cancer development. However, epidemiologic data relating calcium and vitamin D levels to breast cancer have been inconclusive...
  7. pmc Reproducibility of plasma and urine biomarkers among premenopausal and postmenopausal women from the Nurses' Health Studies
    Joanne Kotsopoulos
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:938-46. 2010
    ..Temporal variability of biomarkers should be evaluated before their use in epidemiologic studies...
  8. ncbi Insulin-like growth factor-I, IGF-binding protein-3, and mammographic breast density
    Caroline Diorio
    Unité de recherche en santé des populations, Centre Hospitalier Affilie Universitaire De Quebec, Hôpital Saint Sacrement, 1050 Chemin Sainte Foy, Quebec, Quebec, Canada G1S 4L8
    Cancer Epidemiol Biomarkers Prev 14:1065-73. 2005
    ..They provide additional support for the idea that, among premenopausal women, these growth factors may affect breast cancer risk, at least in part, through their influence on breast tissue morphology as reflected on mammogram...
  9. pmc Obstetric history and mammographic density: a population-based cross-sectional study in Spain (DDM-Spain)
    Virginia Lope
    Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, Monforte de Lemos 5, 28029 Madrid, Spain
    Breast Cancer Res Treat 132:1137-46. 2012
    ..These results suggest the influence of hormones and growth factors over the proliferative activity of the mammary gland...
  10. pmc Pathology parameters and adjuvant tamoxifen response in a randomised premenopausal breast cancer trial
    K Jirstrom
    Division of Pathology Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE 205 02, Malmo, Sweden
    J Clin Pathol 58:1135-42. 2005
    ..These parameters are the net result of combinations of genetic alterations effecting tumour behaviour and could potentially reflect subtypes that respond differently to endocrine treatment...
  11. ncbi Does the Mediterranean dietary pattern or the Healthy Diet Index influence the risk of breast cancer in a large British cohort of women?
    J E Cade
    Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds, UK
    Eur J Clin Nutr 65:920-8. 2011
    ..To assess the risk of developing breast cancer associated with consumption of two common dietary patterns: a Mediterranean dietary pattern and a dietary pattern, which conforms to the World Health Organization Healthy Diet Index (WHO HDI)...
  12. ncbi Early start of adjuvant chemotherapy may improve treatment outcome for premenopausal breast cancer patients with tumors not expressing estrogen receptors. The International Breast Cancer Study Group
    M Colleoni
    European Institute of Oncology, Milan, Italy
    J Clin Oncol 18:584-90. 2000
    ....
  13. pmc Reliability of serum iron, ferritin, nitrite, and association with risk of renal cancer in women
    M Aktar Ali
    Department of Environmental Medicine, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Cancer Detect Prev 27:116-21. 2003
    ..55, 95% CI, 0.15-2.01 for ferritin, and OR, 0.52, 95% CI, 0.17-1.60 for nitrite in women with above median level as compared to women with below median level). The possible role of ferritin and nitrite in renal cancer is discussed...
  14. pmc Combined effects of obesity and type 2 diabetes contribute to increased breast cancer risk in premenopausal women
    Majed S Alokail
    Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia
    Cardiovasc Diabetol 8:33. 2009
    ..We tested this association in type 2 diabetic women, categorized as obese, overweight and normal body weight groups based on BMI...
  15. ncbi Association of coffee, green tea, and caffeine intakes with serum concentrations of estradiol and sex hormone-binding globulin in premenopausal Japanese women
    C Nagata
    Department of Public Health, Gifu University School of Medicine, Japan
    Nutr Cancer 30:21-4. 1998
    ..Although the effect of caffeine cannot be distinguished from effects of coffee and green tea, consumption of caffeine-containing beverages appeared to favorably alter hormone levels associated with the risk of developing breast cancer...
  16. ncbi Two years of adjuvant tamoxifen in premenopausal patients with breast cancer: a randomised, controlled trial with long-term follow-up
    Lisa Rydén
    Department of Surgery, Helsingborgs lasarett, SE 251 85 Helsingborg, Sweden
    Eur J Cancer 41:256-64. 2005
    ..PR status was a significant predictor of response to tamoxifen in multivariate models with testing of interactions of hormone receptor status and adjuvant therapy...
  17. ncbi Interaction between menopausal status and obesity in affecting breast cancer risk
    David P Rose
    Department of Surgery, Mary Babb Randolph Cancer Center, West Virginia University Robert C Byrd Health Sciences Center, Morgantown, WV 26506, USA
    Maturitas 66:33-8. 2010
    ....
  18. ncbi Effects of walking training on weight maintenance after a very-low-energy diet in premenopausal obese women: a randomized controlled trial
    M Fogelholm
    University of Helsinki, Lahti Research and Training Centre, Saimaankatu 11, FIN 15140 Lahti, Finland
    Arch Intern Med 160:2177-84. 2000
    ..Maintenance of weight loss is a core problem in the treatment of obesity. Physical activity may improve maintenance and metabolic risk factors associated with obesity...
  19. ncbi Low bone mass in premenopausal women with depression
    Farideh Eskandari
    Department of Medicine, Division of Clinical and Molecular Endocrinology, Case Western Reserve University, Cleveland, Ohio, USA
    Arch Intern Med 167:2329-36. 2007
    ..An increased prevalence of low bone mineral density (BMD) has been reported in patients with major depressive disorder (MDD), mostly women...
  20. pmc Coffee, tea, caffeine and risk of breast cancer: a 22-year follow-up
    Davaasambuu Ganmaa
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 122:2071-6. 2008
    ..However, our results suggested a weak inverse association between caffeine-containing beverages and risk of postmenopausal breast cancer...
  21. ncbi Use of luteinising-hormone-releasing hormone agonists as adjuvant treatment in premenopausal patients with hormone-receptor-positive breast cancer: a meta-analysis of individual patient data from randomised adjuvant trials
    J Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    Lancet 369:1711-23. 2007
    ..Several trials have been done to assess treatment of premenopausal breast cancer with luteinising-hormone-releasing hormone (LHRH) agonists, but results have been inconclusive, especially for patients with hormone-receptor-positive cancer...
  22. ncbi Plasma 25-hydroxyvitamin D and premenopausal breast cancer risk in a German case-control study
    Sascha Abbas
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 124:250-5. 2009
    ..05, case-only model). Our findings support a protective effect of vitamin D for premenopausal breast cancer...
  23. ncbi Effect of a lifestyle intervention on bone mineral density in premenopausal women: a randomized trial
    L M Salamone
    University of Pittsburgh, Graduate School of Public Health, Department of Epidemiology, Pittsburgh, PA 15261, USA
    Am J Clin Nutr 70:97-103. 1999
    ..The positive association between body weight and bone mineral density (BMD) is well documented; in contrast, the effect of changes in body weight on BMD is not well understood, particularly, in normal-weight populations...
  24. pmc Adiponectin is inversely associated with intramyocellular and intrahepatic lipids in obese premenopausal women
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Obesity (Silver Spring) 19:911-6. 2011
    ....
  25. pmc BioCycle study: design of the longitudinal study of the oxidative stress and hormone variation during the menstrual cycle
    Jean Wactawski-Wende
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 14214, USA
    Paediatr Perinat Epidemiol 23:171-84. 2009
    ..This report describes the study design, baseline characteristics and visit completion rate for the BioCycle study...
  26. ncbi Plasma adiponectin levels and endometrial cancer risk in pre- and postmenopausal women
    Anne E Cust
    Nutrition and Hormones Unit, International Agency for Research on Cancer, 69372 Lyon, France
    J Clin Endocrinol Metab 92:255-63. 2007
    ..Adiponectin, an adipocytokine secreted by adipose tissue, is decreased in obesity, insulin resistance, type 2 diabetes, and polycystic ovary syndrome, all of which are well-established risk factors for endometrial cancer...
  27. ncbi Neoadjuvant anastrozole versus tamoxifen in patients receiving goserelin for premenopausal breast cancer (STAGE): a double-blind, randomised phase 3 trial
    Norikazu Masuda
    National Hospital Organization, Osaka National Hospital, Osaka, Japan
    Lancet Oncol 13:345-52. 2012
    ..We aimed to assess the efficacy and safety of anastrozole versus tamoxifen in premenopausal women receiving goserelin for early breast cancer in the neoadjuvant setting...
  28. ncbi The CYP19 TTTA repeat polymorphism is related to the prognosis of premenopausal stage I-II and operable stage III breast cancers
    Chiun Sheng Huang
    Department of Surgery, National Taiwan University Hospital, No 7, Chung Shan South Road, Taipei, Taiwan
    Oncologist 13:751-60. 2008
    ....
  29. ncbi Metabolic implications of menopause
    Hanah N Polotsky
    Weill Cornell Medical Center and Memorial Sloan Kettering Cancer Center, New York 10065, USA
    Semin Reprod Med 28:426-34. 2010
    ..This review focuses on metabolic changes associated with menopausal transition, specifically alterations in weight, waist circumference, body fat distribution, energy expenditure, and circulating biomarkers including adipokines...
  30. pmc Adult body size, hormone receptor status, and premenopausal breast cancer risk in a multiethnic population: the San Francisco Bay Area breast cancer study
    Esther M John
    Cancer Prevention Institute of California, Fremont, 94538, USA
    Am J Epidemiol 173:201-16. 2011
    ..Despite racial/ethnic differences in body size, inverse associations were similar across the 3 racial/ethnic groups when stratified by hormone receptor status...
  31. ncbi Incidence, time course, and determinants of menstrual bleeding after breast cancer treatment: a prospective study
    Jeanne A Petrek
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 24:1045-51. 2006
    ..To assess ovarian function using the surrogate of monthly bleeding after breast cancer treatment in premenopausal women...
  32. pmc Comparison of DXA and CT in the assessment of body composition in premenopausal women with obesity and anorexia nervosa
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:2227-33. 2010
    ..The level of hydration does not significantly affect most DXA body composition measurements, with the exceptions of thigh fat...
  33. ncbi A longitudinal study of the perimenopausal transition: altered profiles of steroid and pituitary hormones, SHBG and bone mineral density
    G Rannevik
    Department of Obstetrics and Gynecology, University of Lund, , Sweden
    Maturitas 21:103-13. 1995
    ..The impact of this will influence the severity of symptoms, the degree of bone loss and the need for supplementary therapy...
  34. ncbi Premenopausal endocrine-responsive early breast cancer: who receives chemotherapy?
    M M Regan
    IBCSG Statistical Center, Dana Farber Cancer Institute, Harvard School of Public Health, Boston, MA, USA
    Ann Oncol 19:1231-41. 2008
    ..PERCHE closed with inadequate accrual; TEXT accrued rapidly...
  35. ncbi Optimizing endocrine therapy for breast cancer
    Eric P Winer
    J Clin Oncol 23:1609-10. 2005
  36. ncbi Waist circumference, dual-energy X-ray absortiometrically measured abdominal adiposity, and computed tomographically derived intra-abdominal fat area on detecting metabolic risk factors in obese women
    Kayoung Lee
    Department of Family Medicine, Inje University Busan Paik Hospital, Busan, Korea
    Nutrition 24:625-31. 2008
    ....
  37. ncbi The endocrinology of dizygotic twinning in the human
    C B Lambalk
    Research Institute of Endocrinology, Reproduction and Metabolism, Department of Obstetrics and Gynaecology, Medical Centre, Vrije Universiteit, Amsterdam, The Netherlands
    Mol Cell Endocrinol 145:97-102. 1998
    ....
  38. ncbi Estrogen receptor 1 gene polymorphisms in premenopausal women: interaction between genotype and smoking on lipid levels
    S Almeida
    Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
    Braz J Med Biol Res 41:872-6. 2008
    ....
  39. ncbi Measurement of androgens in women
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Semin Reprod Med 24:78-85. 2006
    ..Androgens also can be measured in saliva, but major methodologic problems are associated with the measurements. In addition, there is a misconception that salivary testosterone levels reflect free testosterone levels in serum...
  40. ncbi Carbohydrate intake modulates the effect of the ABCA1-R230C variant on HDL cholesterol concentrations in premenopausal women
    Sandra Romero-Hidalgo
    Computational Genomics Department, Instituto Nacional de Medicina Genomica, Mexico City, Mexico
    J Nutr 142:278-83. 2012
    ..This finding may help design optimized dietary interventions according to sex and ABCA1-R230C genotype...
  41. ncbi Effect of vitamin D, calcium and multiple micronutrient supplementation on vitamin D and bone status in Bangladeshi premenopausal garment factory workers with hypovitaminosis D: a double-blinded, randomised, placebo-controlled 1-year intervention
    Md Zahirul Islam
    Calcium Research Unit, Division of Nutrition, Department of Applied Chemistry and Microbiology, PO Box 66, 00014 University of Helsinki, Finland
    Br J Nutr 104:241-7. 2010
    ..Supplementation with VD-Ca should be recommended as a strategic option to reduce the risk of osteomalacia and osteoporosis in these subjects. MMN-Ca may have analogous positive health implications with additional non-skeletal benefits...
  42. pmc Reproducibility of fifteen urinary estrogens and estrogen metabolites over a 2- to 3-year period in premenopausal women
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:2860-8. 2009
    ..Within-person reproducibility over time for most EM measures is comparable to or better than that for well-vetted biomarkers such as plasma cholesterol and, in postmenopausal women, estradiol...
  43. pmc Urinary estrogens and estrogen metabolites and subsequent risk of breast cancer among premenopausal women
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 72:696-706. 2012
    ..The inverse associations with parent estrogen metabolites and the parent estrogen metabolite/non-parent estrogen metabolite ratio suggest that women with higher urinary excretion of parent estrogens are at lower risk...
  44. pmc Effects of iron deficiency and iron overload on angiogenesis and oxidative stress-a potential dual role for iron in breast cancer
    Jinlong Jian
    Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA
    Free Radic Biol Med 50:841-7. 2011
    ....
  45. ncbi Bone loss during menopausal transition among southern Chinese women
    Elaine Cheung
    Department of Medicine, United Christian Hospital, Hong Kong, China
    Maturitas 69:50-6. 2011
    ..Estrogen deficiency during menopausal transition is associated with rapid bone loss. The purpose of this study was to examine the time of onset, the rate, and predictors of menopausal bone loss...
  46. ncbi Combined tamoxifen and luteinizing hormone-releasing hormone (LHRH) agonist versus LHRH agonist alone in premenopausal advanced breast cancer: a meta-analysis of four randomized trials
    J G Klijn
    Dr Daniel den Hoed Kliniek and University Hospital, Rotterdam, The Netherlands
    J Clin Oncol 19:343-53. 2001
    ..Therefore, if a premenopausal woman with advanced breast cancer is thought to be suitable for endocrine treatment, it is proposed that the combination of a LHRH agonist plus tamoxifen be considered as the new standard treatment...
  47. pmc Longer therapy, iatrogenic amenorrhea, and survival in early breast cancer
    Sandra M Swain
    National Surgical Adjuvant Breast and Bowel Project, Washington Cancer Institute at Washington Hospital Center, Washington, DC 20010, USA
    N Engl J Med 362:2053-65. 2010
    ..The effectiveness of concurrent versus sequential regimens is not known...
  48. ncbi Endogenous oestrogens and breast cancer risk in premenopausal and postmenopausal women
    Timothy J Key
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX37LF, UK
    Steroids 76:812-5. 2011
    ..Further data are required, with better assays and repeat measures, to provide more accurate estimates of risk and to clarify the role of oestrogens in premenopausal women and the roles of other endogenous hormones...
  49. ncbi Adult weight gain in relation to breast cancer risk by estrogen and progesterone receptor status: a meta-analysis
    Alina Vrieling
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Breast Cancer Res Treat 123:641-9. 2010
    ..In conclusion, the association between adult weight gain and postmenopausal breast cancer risk is heterogeneous according to ER/PR status and stronger for ER(+)PR(+) than for ER(-)PR(-) tumors...
  50. pmc Influence of menopause on high density lipoprotein-cholesterol and lipids
    C J Kim
    Department of Internal Medicine, Chung Ang University Medical Center, Seoul, Korea
    J Korean Med Sci 15:380-6. 2000
    ..051). Total cholesterol levels showed stepwise elevation from premenopause to postmenopause. Perimenopausal women had lower Lp(a) levels than postmenopausal women (p<0...
  51. pmc A case-control study of body mass index and breast cancer risk in white and African-American women
    Paula Berstad
    Institute of Basic Medical Sciences, Department of Nutrition, University of Oslo, Oslo, Norway
    Cancer Epidemiol Biomarkers Prev 19:1532-44. 2010
    ..Limited information is available about African-American women and differences by estrogen and progesterone receptor status...
  52. pmc Body fat distribution and risk of premenopausal breast cancer in the Nurses' Health Study II
    Holly R Harris
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    J Natl Cancer Inst 103:273-8. 2011
    ..01) for waist to hip ratio. Our findings suggest that body fat distribution does not play an important role in the overall incidence of premenopausal breast cancer but is associated with an increased risk for ER-negative breast cancer...
  53. pmc Sources of cadmium exposure among healthy premenopausal women
    Scott V Adams
    Fred Hutchinson Cancer Research Center, PO Box 19024, M4 B402, Seattle, WA 98109, USA
    Sci Total Environ 409:1632-7. 2011
    ..Cigarettes are the dominant source of cadmium exposure among smokers; the primary source of cadmium in non-smokers is food. We investigated sources of cadmium exposure in a sample of healthy women...
  54. ncbi Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Rudolf Kaaks
    Nutrition and Hormones Group, International Agency for Research on Cancer IARC WHO, Lyon, France
    J Natl Cancer Inst 97:755-65. 2005
    ..We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort to examine associations among premenopausal serum concentrations of sex steroids and subsequent breast cancer risk...
  55. ncbi Leptin, body composition and bone mineral density in premenopausal women
    M Blum
    Calcium and Metabolic Bone Laboratory, Jean Mayer United States Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Calcif Tissue Int 73:27-32. 2003
    ..In summary, the results of this study suggest that for a given body weight, a higher proportion of fat and a higher serum leptin concentration have negative associations with bone mass in premenopausal women...
  56. ncbi Comparison of the effects of cows' milk, fortified soy milk, and calcium supplement on weight and fat loss in premenopausal overweight and obese women
    Sh Faghih
    Department of Nutrition, Faculty of Nutrition Sciences and Food Technology, Arghavan Ave, Farahzadi Bulv, Tehran, Iran
    Nutr Metab Cardiovasc Dis 21:499-503. 2011
    ..We compared the effects of cows' milk, calcium fortified soy milk and calcium supplement on weight and body fat reduction in premenopausal overweight and obese women...
  57. ncbi A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin levels through the menopause transition
    H G Burger
    Prince Henry s Institute of Medical Research, Monash Medical Center, Clayton, Victoria, Australia
    J Clin Endocrinol Metab 85:2832-8. 2000
    ..DHEAS decreases as a function of age, not time relative to FMP, and T remains unchanged during the menopausal years. SHBG and DHEAS show a high degree of stability within an individual over time...
  58. ncbi Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods
    Aedin Cassidy
    School of Medicine, University of East Anglia, Norwich, UK
    J Nutr 136:45-51. 2006
    ..Only 30% of the subjects were equol producers and no differences in equol production with age or gender were observed...
  59. ncbi Effects of high-impact exercise on bone mineral density: a randomized controlled trial in premenopausal women
    Aki Vainionpää
    Department of Medical Technology, University of Oulu, PO Box 5000, 90014, Oulu, Finland
    Osteoporos Int 16:191-7. 2005
    ..The purpose of this randomized controlled study was to assess the effects of high-impact exercise on the bone mineral density (BMD) of premenopausal women at the population level...
  60. ncbi Selective estrogen-receptor modulators for primary prevention of breast cancer
    Carol J Fabian
    Department of Internal Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Clin Oncol 23:1644-55. 2005
  61. ncbi Determinants of recovery from amenorrhea in premenopausal breast cancer patients receiving adjuvant chemotherapy in the taxane era
    Alessandro Marco Minisini
    Department of Medical Oncology, University Hospital of Udine, Udine, Italy
    Anticancer Drugs 20:503-7. 2009
    ..04) were associated with an increased probability of permanent chemotherapy-induced amenorrhea. Recovery of menses after chemotherapy-induced amenorrhea occurs more probably in younger women, with no pregnancies and receiving taxanes...
  62. ncbi Spectroscopy enhances the information content of optical mammography
    A E Cerussi
    University of California, Irvine, Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Rd, Irvine, California 92612, USA
    J Biomed Opt 7:60-71. 2002
    ..Multi-spectral measurements, compared to measurements restricted to one or two wavelengths, provide additional information that may be useful in managing breast disease...
  63. ncbi Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial
    Christopher D Gardner
    Stanford Prevention Research Center and the Department of Medicine, Stanford University Medical School, Stanford, Calif, USA
    JAMA 297:969-77. 2007
    ..Popular diets, particularly those low in carbohydrates, have challenged current recommendations advising a low-fat, high-carbohydrate diet for weight loss. Potential benefits and risks have not been tested adequately...
  64. ncbi Stress may add bite to appetite in women: a laboratory study of stress-induced cortisol and eating behavior
    E Epel
    UCSF Health Psychology Program, 3333 California St, Suite 465, San Francisco, CA 94118, USA
    Psychoneuroendocrinology 26:37-49. 2001
    ..These results suggest that psychophysiological response to stress may influence subsequent eating behavior. Over time, these alterations could impact both weight and health...
  65. ncbi The rates of chemotherapy-induced amenorrhea in patients treated with adjuvant doxorubicin and cyclophosphamide followed by a taxane
    Yee Lu Tham
    Breast Care Center, The Methodist Hospital and Baylor College of Medicine, Houston, Texas, USA
    Am J Clin Oncol 30:126-32. 2007
    ..The incidence of chemotherapy-induced amenorrhea (CIA) resulting from doxorubicin and cyclophosphamide (AC) followed by a taxane (T) is poorly characterized...
  66. ncbi Ethnic variation in bone turnover in pre- and early perimenopausal women: effects of anthropometric and lifestyle factors
    Joel S Finkelstein
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA org
    J Clin Endocrinol Metab 87:3051-6. 2002
    ..Other factors, such as differences in bone accretion, are likely responsible for much of the ethnic variation in adult BMD...
  67. pmc Fat/fiber intakes and sex hormones in healthy premenopausal women in USA
    Mylene Aubertin-Leheudre
    Folkhalsan Research Center, Institute of Preventive Medicine, Nutrition and Cancer, Division of Clinical Chemistry, University of Helsinki, Finland
    J Steroid Biochem Mol Biol 112:32-9. 2008
    ..Our results suggest that fat affects estrogen metabolism more than does fiber and that one mechanism resulting in high estrogen values is an increased reabsorption of biliary estrogens...
  68. ncbi Obesity and outcomes in premenopausal and postmenopausal breast cancer
    Sherene Loi
    Peter MacCallum Cancer Centre, 723 Swanston Street, Carlton, Victoria 3053, Australia
    Cancer Epidemiol Biomarkers Prev 14:1686-91. 2005
    ..Obesity is associated with adverse outcomes in postmenopausal women with breast cancer. In premenopausal women, the association is less clear...
  69. ncbi IGF-I and mammographic density in four geographic locations: a pooled analysis
    Gertraud Maskarinec
    Cancer Research Center, University of Hawaii, Honolulu, HI 96813, USA
    Int J Cancer 121:1786-92. 2007
    ..Based on this analysis, the influence of circulating levels of IGF-I, IGFBP-3, and prolactin on percent density appears to be very small...
  70. ncbi What survival benefits do premenopausal patients with early breast cancer need to make endocrine therapy worthwhile?
    Belinda Thewes
    Prince of Wales Hospital, Randwick, Sydney, Australia
    Lancet Oncol 6:581-8. 2005
    ..We aimed to quantify the survival gains that premenopausal patients with early-stage breast cancer require to justify the side-effects and inconvenience of adjuvant endocrine treatments...
  71. pmc Low 24-hour adiponectin and high nocturnal leptin concentrations in a case-control study of community-dwelling premenopausal women with major depressive disorder: the Premenopausal, Osteopenia/Osteoporosis, Women, Alendronate, Depression (POWER) study
    Giovanni Cizza
    Clinical Endocrine Section, Clinical Endocrinology Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1613, USA
    J Clin Psychiatry 71:1079-87. 2010
    ....
  72. ncbi Amenorrhea in premenopausal women on the doxorubicin-and-cyclophosphamide-followed-by-docetaxel arm of NSABP B-30 trial
    Sandra M Swain
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA
    Breast Cancer Res Treat 113:315-20. 2009
    ..These results can be used to inform premenopausal women about the risk and time course of amenorrhea associated with this common adjuvant therapy regimen, along with the effects on symptoms and QOL...
  73. pmc Prospective case-control study of serum mullerian inhibiting substance and breast cancer risk
    Joanne F Dorgan
    Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    J Natl Cancer Inst 101:1501-9. 2009
    ..The objective of this study was to determine whether serum MIS levels are associated with breast cancer risk...
  74. pmc Oral contraceptive use and bone mineral density in premenopausal women: cross-sectional, population-based data from the Canadian Multicentre Osteoporosis Study
    J C Prior
    Department of Medicine, University of British Columbia, and Vancouver Hospital
    CMAJ 165:1023-9. 2001
    ..This study assessed the relation between OC use and BMD in a population-based, 9-centre, national sample of women aged 25-45 years...
  75. ncbi Menopause, coronary artery disease and antioxidants
    M Krstevska
    Department of Medical and Experimental Biochemistry, Medical Faculty, Skopje, Republic of Macedonia
    Clin Chem Lab Med 39:641-4. 2001
    ..02) in comparison with the control group. TAS was not changed in women with CAD in comparison with controls. In conclusion, menopause leads to the reduction of the level of antioxidants, especially in women with CAD...
  76. pmc Several anthropometric measurements and breast cancer risk: results of the E3N cohort study
    B Tehard
    Equipe Inserm IGR Nutrition, Hormones, Cancer, Institut Gustave Roussy, Villejuif, France
    Int J Obes (Lond) 30:156-63. 2006
    ..To investigate the association between various anthropometric characteristics and breast cancer...
  77. ncbi Letrozole plus GnRH analogue as preoperative and adjuvant therapy in premenopausal women with ER positive locally advanced breast cancer
    Rosalba Torrisi
    Research Unit of Medical Senology at the Department of Medicine, European Institute of Oncology, Milano, Italy
    Breast Cancer Res Treat 126:431-41. 2011
    ....
  78. ncbi Effects of menopause on intraindividual changes in serum lipids, blood pressure, and body weight--the Chin-Shan Community Cardiovascular Cohort study
    Pao Ling Torng
    Department of Obstetric and Gynecology, National Taiwan University College of Medicine, Taipei 10020, Taiwan, ROC
    Atherosclerosis 161:409-15. 2002
    ..5 and 14.7% in all groups. This study suggests an unfavorable effect of menopause on lipid metabolism, especially on the TC level, which was predominantly elevated during the transition to menopause. The decline of HDL-C is of concern...
  79. pmc Luteinizing hormone-releasing hormone analogues--the rationale for adjuvant use in premenopausal women with early breast cancer
    W Jonat
    Gynaecology and Obstetrics Clinic, University of Kiel, Germany
    Br J Cancer 78:5-8. 1998
    ..A number of large, randomized trials are now in progress to assess the potential role of goserelin as adjuvant therapy for early breast cancer...
  80. ncbi Body weight and incidence of breast cancer defined by estrogen and progesterone receptor status--a meta-analysis
    Reiko Suzuki
    Institute of Environmental Medicine, Division of Nutritional Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 124:698-712. 2009
    ..The relation between body weight and breast cancer risk is critically dependent on the tumor's ER/PR status and the woman's menopausal status. Body weight control is the effective strategy for preventing ER+PR+ tumors after menopause...
  81. ncbi Chemotherapy is more effective in patients with breast cancer not expressing steroid hormone receptors: a study of preoperative treatment
    Marco Colleoni
    Department of Medicine, European Institute of Oncology, Milan, Italy
    Clin Cancer Res 10:6622-8. 2004
    ..The purpose of this research was to identify factors predicting response to preoperative chemotherapy...
  82. ncbi Randomized adjuvant trial of tamoxifen and goserelin versus cyclophosphamide, methotrexate, and fluorouracil: evidence for the superiority of treatment with endocrine blockade in premenopausal patients with hormone-responsive breast cancer--Austrian Breas
    Raimund Jakesz
    Department of Surgery, Vienna University, Vienna General Hospital, Austria
    J Clin Oncol 20:4621-7. 2002
    ..The purpose of Austrian Breast and Colorectal Cancer Study Group Trial 5 was to compare the efficacy of a combination endocrine treatment with standard chemotherapy...
  83. ncbi SERMs for the treatment and prevention of breast cancer
    Ramona F Swaby
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Rev Endocr Metab Disord 8:229-39. 2007
    ..Overall, SERMs continue to fulfill their promise as appropriate medicines that target specific populations for the treatment and prevention of breast cancer...
  84. pmc A prospective study of urinary oestrogen excretion and breast cancer risk
    T J Key
    Imperial Cancer Research Fund, Cancer Epidemiology Unit, Radcliffe Infirmary, Oxford, UK
    Br J Cancer 73:1615-9. 1996
    ..016). We conclude that high levels of endogenous oestrogens in post-menopausal women are associated with increased breast cancer risk, but that the relationship of oestrogens in premenopausal women with risk is unclear...
  85. ncbi Low iron stores: a risk factor for excessive hair loss in non-menopausal women
    Claire Deloche
    L Oreal Recherche, Clichy, France
    Eur J Dermatol 17:507-12. 2007
    ..Analysis of variance and logistic regression show that a low iron store represents a risk factor for hair loss in non-menopausal women...
  86. ncbi Grand multiparity and the risk of breast cancer: population-based study in Finland
    M Hinkula
    Department of Obstetrics and Gynaecology, Oulu University Hospital, Finland
    Cancer Causes Control 12:491-500. 2001
    ..We extended these studies to a nationwide cohort of women with at least five births (grand multiparas = GM) by assessing the significance of parity, age at first birth, and average birth interval to the risk of breast cancer...
  87. pmc Prospective case-control study of premenopausal serum estradiol and testosterone levels and breast cancer risk
    Joanne F Dorgan
    Fox Chase Cancer Center, hiladelphia, PA 19111, USA
    Breast Cancer Res 12:R98. 2010
    ..The objective of this study was to determine whether estradiol and testosterone levels in serum collected before menopause are associated with subsequent breast cancer risk...
  88. pmc Pre- versus postmenopausal age, estradiol, and peptide-secretagogue type determine pulsatile growth hormone secretion in healthy women: studies using submaximal agonist drive and an estrogen clamp
    Susan B Hudson
    Department of Obstetrics and Gynecology, Mayo School of Graduate Medical Education, Clinical Translational Research Center, Mayo Clinic, Rochester, Minnesota 55905
    J Clin Endocrinol Metab 95:353-60. 2010
    ..GH-releasing peptide (GHRP), GHRH, and somatostatin are physiological regulators of pulsatile GH secretion...
  89. pmc Body size across the life course, mammographic density, and risk of breast cancer
    Holly R Harris
    Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Epidemiol 174:909-18. 2011
    ..Conversely, mammographic density does not appear to explain the inverse association between childhood and adolescent body fatness and breast cancer risk...
  90. ncbi Dietary vitamin D and calcium intake and premenopausal breast cancer risk in a German case-control study
    Sascha Abbas
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Nutr Cancer 59:54-61. 2007
    ..29). No statistically significant interaction between the 2 nutrients was observed. Our data support a protective effect of dietary vitamin D on premenopausal breast cancer risk independent of dietary calcium intake...
  91. ncbi Does the intensity of an exercise programme modulate body composition changes?
    V Mougios
    Laboratory of Sport Hygiene and Nutrition, Department of Physical Education and Sport Science, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Int J Sports Med 27:178-81. 2006
    ..Thus, both programmes may prove useful in eliciting favourable changes depending on which target (weight loss or maintenance of fat-free mass) is of higher priority...
  92. pmc Urinary estrogen metabolites during a randomized soy trial
    Yukiko Morimoto
    University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA
    Nutr Cancer 64:307-14. 2012
    ..13) and nonproducers (P = 0.23). These findings suggest a beneficial influence of soy foods on estrogen metabolism regardless of equol producer status...
  93. ncbi Associations between mammographic density and body composition in Hispanic and non-Hispanic white women by menopause status
    Graciela Caire-Juvera
    Nutrition Department, Centro de Investigacion en Alimentacion y Desarrollo, Sonora, Mexico
    Menopause 15:319-25. 2008
    ..To evaluate the associations of body composition, including percentage of lean and fat mass, with the percentage of mammographic density and mammographic dense area among pre- and postmenopausal Hispanic and non-Hispanic white women...
  94. ncbi Association of serum undercarboxylated osteocalcin with serum estradiol in pre-, peri- and early post-menopausal women
    T Yasui
    Department of Obstetrics and Gynecology, School of Medicine, University of Tokushima, Tokushima 770 8503, Japan
    J Endocrinol Invest 29:913-8. 2006
    ....
  95. ncbi Reference curve of bone ultrasound measurements in proximal phalanges in normal Spanish women
    Juan Diego Pedrera Zamorano
    Department of Medicine, University of Alcala, Madrid, Spain
    J Clin Densitom 6:373-80. 2003
    ..The premenopausal decline in AD-SoS requires further longitudinal studies, although in our experience it may depend on dietary habits and/or a diminished quality, though not quantity, of bone in this period of a woman's fertile life...
  96. ncbi Safety and efficacy of a testosterone metered-dose transdermal spray for treating decreased sexual satisfaction in premenopausal women: a randomized trial
    Susan Davis
    Women s Health Program, Department of Medicine, Monash University, Alfred Hospital, Prahran, Victoria, Australia
    Ann Intern Med 148:569-77. 2008
    ..It is not known whether premenopausal women who report low sexual satisfaction and have low circulating testosterone levels will benefit from testosterone therapy...
  97. pmc The volume of nipple aspirate fluid is not affected by 6 months of treatment with soy foods in premenopausal women
    Gertraud Maskarinec
    University of Hawaii Cancer Center, Honolulu, HI 96813, USA
    J Nutr 141:626-30. 2011
    ..50 for diet; P-interaction = 0.21 for diet with time). Contrary to an earlier report, soy foods in amounts consumed by Asians did not increase breast tissue activity as assessed by NAF volume...
  98. ncbi Combined treatment with buserelin and tamoxifen in premenopausal metastatic breast cancer: a randomized study
    J G Klijn
    Department of Medical Oncology, Rotterdam Cancer Institute, University Hospital Rotterdam, The Netherlands
    J Natl Cancer Inst 92:903-11. 2000
    ....
  99. ncbi Serum high-density lipoprotein cholesterol, metabolic profile, and breast cancer risk
    Anne Sofie Furberg
    Section of Epidemiology and Medical Statistics, Institute of Community Medicine, Faculty of Medicine, University of Tromsø, Tromsø, Norway
    J Natl Cancer Inst 96:1152-60. 2004
    ..HDL-C represents an important aspect of the syndrome, yet its role in breast cancer is still undefined...
  100. ncbi Physical exercise reduces risk of breast cancer in Japanese women
    Kaoru Hirose
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681
    Cancer Sci 94:193-9. 2003
    ..This study provides evidence that physical exercise, especially exercise twice a week or more, reduces the risk of breast cancer among Japanese women...
  101. pmc Estrogen levels in nipple aspirate fluid and serum during a randomized soy trial
    Gertraud Maskarinec
    University of Hawaii Cancer Center, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 20:1815-21. 2011
    ..On the basis of hypothesized protective effect, we examined the effect of soy foods on estrogens in nipple aspirate fluid (NAF) and serum, possible indicators of breast cancer risk...

Research Grants65

  1. Neurobiology of the Menopausal Transition
    Yolanda R Smith; Fiscal Year: 2010
    ..Recruits will be women aged 40-55 years, stratified into panels representing premenopause, early perimenopause, late perimenopause and natural postmenopause defined by follicle-stimulating hormone ..
  2. Hot flashes and memory dysfunction in the perimenopause
    MIRIAM T WEBER; Fiscal Year: 2013
    ..vasomotor symptoms (VMS;hot flashes and night sweats) are a mechanism for memory changes in the transition from premenopause to perimenopause to postmenopause...
  3. Inflammatory Markers in a 2-Year Soy Intervention among Premenopausal Women
    Gertraud Maskarinec; Fiscal Year: 2008
    ..The statistical analysis will apply general linear models to compare the levels of inflammatory markers by soy intake, while taking into account the repeated measurement design. [unreadable] [unreadable] [unreadable] [unreadable]..
  4. Breast Density, IGF-I, & Prolactin, in Four Populations
    Gertraud Maskarinec; Fiscal Year: 2004
    ..The statistical analysis will include mixed models to explore the relation between hormone levels and breast density while controlling for confounders and for clustering by study location. ..
  5. Soy Consumption and Breast Tissue Proliferation
    Gertraud Maskarinec; Fiscal Year: 2006
    ....
  6. Effects of Soy on Estrogens in Breast Fluid and Urine
    Gertraud Maskarinec; Fiscal Year: 2010
    ..The NAF approach is the only way to learn more about the beneficial and adverse effects of soy directly in the female breast without applying invasive procedures to women without breast disease or surgery. ..
  7. NESTED CASE CONTROL STUDY OF MAMMOGRAPHIC DENSITY
    Gertraud Maskarinec; Fiscal Year: 2002
    ....
  8. Nutritional Risk Factors for Type 2 Diabetes in the Multiethnic Cohort
    Gertraud Maskarinec; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  9. Estrogen, Metabolism, Menopause, and Health Outcomes
    MaryFran Sowers; Fiscal Year: 2006
    ..This is a unique opportunity to prospectively integrate lifestyle elements with measures of hormone metabolism pathways into a comprehensive examination of multiple human health effects. ..
  10. Functional Status and the Menopause Transition
    MaryFran R Sowers; Fiscal Year: 2010
    ..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men. ..
  11. SWAN Sleep Study II - Michigan Center
    MaryFran Sowers; Fiscal Year: 2008
    ..The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. [unreadable] [unreadable] [unreadable]..
  12. Change in Bone, Arthritis, Function: Hormones & Obesity
    MaryFran Sowers; Fiscal Year: 2009
    ....
  13. Frequency of aerobic/resistance training in older women
    Gary Hunter; Fiscal Year: 2009
    ..Such information is critical to our understanding of ways to improve well being, quality of life, and independence of an aging population. ..
  14. A Pilot Trial of Oral Melatonin Supplementation in Breast Cancer Survivors
    Eva Schernhammer; Fiscal Year: 2007
    ..This pilot data could lay the groundwork for a large scale trial to assess the chemopreventive potential of melatonin in women, both with and without a personal history of breast cancer. [unreadable] [unreadable] [unreadable]..
  15. Aspartame Intake and the Risk of Cancer
    Eva Schernhammer; Fiscal Year: 2008
    ..Our results may help decision-makers formulate guidelines and direct future aspartame studies. Even a null finding would be important in this context. [unreadable] [unreadable] [unreadable]..
  16. Clock Genes, Night Work, and Breast Cancer Risk
    Eva Schernhammer; Fiscal Year: 2008
    ..The results from this study could help identify individuals who are more susceptible to night work than others, based on their genetic profile. ..
  17. Effects of Light at Night on Circadian System in Nurses
    Eva Schernhammer; Fiscal Year: 2008
    ..abstract_text> ..
  18. ADJUVANT HORMONAL THERAPY IN VIETNAMESE BREAST CANCER
    Richard Love; Fiscal Year: 2005
    ..The investigators have a trial with a rich database and systems to develop further useful data on breast cancer relevant to all women. ..
  19. The Role of Prolactin in the Etiology of Postmenopausal Breast Cancer
    Shelley Tworoger; Fiscal Year: 2008
    ..This potentially may affect public health by increasing our understanding of how breast cancer develops, which in turn can lead to a better understanding of how to prevent this disease. [unreadable] [unreadable]..
  20. Breast Cancer Prediction Using Nipple Aspirate Fluid
    Edward Sauter; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  21. The Yoga for Hyperkyphosis Trial
    Gail Greendale; Fiscal Year: 2007
    ..At the end of this phase we will again measure study endpoints to assess whether participants have maintained the physical function achieved at the end of the RCT. ..
  22. Protein Profiling in Nipple Aspirate Fluid
    Edward Sauter; Fiscal Year: 2007
    ..abstract_text> ..
  23. Ovarian Failure Among Hysterectomized Women
    Patricia Moorman; Fiscal Year: 2007
    ..It should have considerable public health impact given the high frequency of the procedure and the important health consequences of early ovarian failure. ..
  24. Sex Steroids & Mammographic Density in the Postmenopause
    Gail Greendale; Fiscal Year: 2007
    ..We will quantify the relations between the hormone and genetic exposures measured in this project and mammographic density (at baseline as well as change in density between baseline and 12 months). ..
  25. Metabolic and Epidemiologic Evaluation of Choline and Betaine Intake
    Eunyoung Cho; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  26. The Effect of Black Cohosh Extract on the Human Breast
    Edward Sauter; Fiscal Year: 2004
    ..The findings should allow us to design a high quality R01 submission involving a larger, randomized study of longer duration which should provide some answers on the potential role of BCE in breast cancer. ..
  27. Altered Breast Methylation after Low/Hi Dose Isoflavones
    Edward Sauter; Fiscal Year: 2005
    ..abstract_text> ..
  28. Menopause Depression and Aging
    Joyce T Bromberger; Fiscal Year: 2010
    ..Increasing knowledge of the risks for depression in aging women and the factors that protect them from depression can identify targets for intervention at the prevention as well as the acute treatment level. ..
  29. Evaluation of Biological Relevance of Choline Intake
    Eunyoung Cho; Fiscal Year: 2005
    ..The results from the proposed grant will enhance understanding of the role of choline intake in humans and lay the groundwork for future studies on choline intake and overall methyl-group-deficient diet and cancer. ..
  30. Lifetime body weight and premenopausal breast cancer
    KARIN MICHELS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  31. Maternal obesity, intrauterine gene expression and breast cancer
    KARIN MICHELS; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  32. METHODOLOGIC ISSUES IN NUTRITIONAL EPIDEMIOLOGY
    KARIN MICHELS; Fiscal Year: 2002
    ..We aim to provide guidance to researchers who wish to explore diet-disease relations in how to use data best to obtain most valid results and avoid pitfalls which might produce misleading associations. ..
  33. Breast Cancer Prevention by Letrozole in High Risk Women
    Carol J Fabian; Fiscal Year: 2010
    ....
  34. Breast Cancer Risk Biomarkers and Energy Balance
    CAROL FABIAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  35. CHEMOPREVENTION FOR WOMEN AT HIGH RISK OF BREAST CANCER
    CAROL FABIAN; Fiscal Year: 2003
    ..The answer impacts on the entire future of breast cancer chemoprevention development efforts. ..
  36. Mammographic Density and Soy Isoflavones
    Lee Jane W Lu; Fiscal Year: 2010
    ..The study may lead to a novel, non-invasive and economical approach to breast cancer prevention. ..
  37. MODELING THE MENOPAUSAL TRANSITION AND MENOPAUSE
    JAY KAPLAN; Fiscal Year: 2008
    ..Therefore the proposed program is directly relevant to the missions of multiple NIHInstitutes, including - butnot limited to - NIA, NICHD, NHLBI, NIDDKand NIMH. ..
  38. Bone Response to Soy Isoflavones in Women
    D Lee Alekel; Fiscal Year: 2008
    ....
  39. SOY, LIFE STAGE, STRESS AND ATHEROSCLEROSIS IN FEMALES
    JAY KAPLAN; Fiscal Year: 2009
    ....
  40. Phytoestrogens and breast cancer risk
    Susan McCann; Fiscal Year: 2006
    ..These investigations, combining retrospective and experimental designs, as well as genetic analyses, will help to elucidate the role of dietary phytoestrogen intake in the etiology of a hormone- sensitive cancer. ..
  41. FlaxSeed Lignan for Breast Cancer Chemoprevention
    CAROL FABIAN; Fiscal Year: 2007
    ..If positive, the results of this study will be critical to the design and implementation of a placebo-controlled Phase II prevention trial with Brevail and/or commercial flaxseed. [unreadable] [unreadable]..
  42. Estrogen and Aging effects on Transvaginal Transport
    George Gorodeski; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  43. Validation of Preschool and High School Diet Recall
    KARIN MICHELS; Fiscal Year: 2006
    ..Lastly we will determine whether the validity of recall depends on characteristics such as time between diet record and FFQ, number of children, gender of the subject, and nutritional status. ..
  44. Effects of Early Abuse on Adult Intimate Relationships
    Cindy M Meston; Fiscal Year: 2010
    ..The findings from this investigation will have implications for understanding both the psychological and physiological mechanisms that link CA with detrimental intimacy/relational factors in adulthood. ..
  45. Pittsburgh Mind-Body Center-II
    Karen Matthews; Fiscal Year: 2008
    ..Support-in-kind from the host institutions will enable us to leverage the funds provided by the RFA to expand Center activities that would not otherwise be possible. ..
  46. Adolescent Diet, Hormones & Breast Cancer Susceptibility
    Joanne Dorgan; Fiscal Year: 2008
    ..Because diet is a modifiable risk factor, results of this proposed study could be used to develop strategies for prevention. ..
  47. EPIDEMIOLOGIC STUDY OF THE LATE REPRODUCTIVE YEARS
    Ellen W Freeman; Fiscal Year: 2010
    ..abstract_text> ..
  48. REDUCTION OF TRIGLYCERIDES IN WOMEN ON HRT
    Lewis Kuller; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  49. RELAPSE AND PREDICTORS OF DEPRESSION IN PREGNANCY
    Lee Cohen; Fiscal Year: 2003
    ..Delineating of these subgroups provides an opportunity to screen for women "at risk" for relapse and allows for thoughtful treatment plan. ..
  50. Ginkgo Biloba: Antidepressant-Induced Sexual Dysfunction
    Cindy Meston; Fiscal Year: 2003
    ..If effective, GBE could play a significant adjunctive role in the treatment of clinical depression and other psychological disorders commonly treated with antidepressant medications. ..
  51. Pregnancy Hormonal Profile/Biomarker Breast Cancer Risk
    Alan Arslan; Fiscal Year: 2004
    ..Moreover, specific hormone(s) or its analogues responsible for protective effect of pregnancy against breast cancer could be used for development of novel strategies for primary chemoprevention of breast cancer. ..
  52. ENSEMBLE MODEL OF STRESS ACTH-ADRENAL AXIS
    Johannes Veldhuis; Fiscal Year: 2005
    ....
  53. THE AGING GH AXIS IN POSTMENOPAUSAL WOMEN
    Johannes Veldhuis; Fiscal Year: 2005
    ..An enhanced knowledge base should aid ultimately in formulating more innovative preventive and interventional strategies to limit hyposomatotropism in older and/or estrogen-deficient humans. ..
  54. Serum Vitamin D, Genetic Polymorphisms & Ovarian Cancer
    Alan Arslan; Fiscal Year: 2005
    ..abstract_text> ..
  55. ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLES
    Johannes Veldhuis; Fiscal Year: 2005
    ..Understanding such fundamental interactions is important to the rational design of alternative strategies to interrupt normal and rescue impaired steroidogenesis in the maturing Graafian follicle and corpus luteum. ..
  56. OBESITY IN BLACK WOMEN
    Jeanine Albu; Fiscal Year: 2001
    ....
  57. Luminal Lipid Exposure, Genetics and Colon Cancer Risk
    Ikuko Kato; Fiscal Year: 2006
    ..In addition, accumulated dietary data and biological specimens will serve as an important resource for future research on other nutrient-gene interactions. ..
  58. Prognostic Significance of DNA and Histone Methylation
    Chandrika Piyathilake; Fiscal Year: 2007
    ..Investigator talent, equipment, facilities and access to study subjects at UAB are ideal for conducting this study. ..
  59. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    MOLLY CARR; Fiscal Year: 2004
    ..They will also elucidate the mechanisms that underlie the shifts in LDL size with oral and transdermal ERT. ..
  60. Lifestyle Factors and Type 2 Diabetes in Black Women
    Julie Palmer; Fiscal Year: 2008
    ..Because the follow-up and data collection are funded by another grant, the proposed large study of modifiable risk factors for type 2 diabetes can be carried out at a relatively modest cost. ..
  61. DNA METHYLATION AS A DETERMINANT OF BREAST CANCER
    Nancy Davidson; Fiscal Year: 2002
    ..Taken together these studies should provide new insights into the biology of hormone resistance and possible novel therapeutic targets. ..
  62. Osteoporosis Prevention in Early Stage Breast Cancer
    Dawn Hershman; Fiscal Year: 2006
    ..abstract_text> ..
  63. c-erbB-2 and Risk of Contralateral Breast Cancer
    Christopher Li; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  64. Telomere dysfunction, oxidative damage and breast cancer risk
    Jing Shen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  65. BEHAVIORAL CORRELATES OF RECURRENCE IN BREAST CANCER
    Bette Caan; Fiscal Year: 2003
    ..It will also establish a resource for future studies where predictors of long term survival can be examined ..