perimenopause

Summary

Summary: The transitional period before and after MENOPAUSE. Perimenopausal symptoms are associated with irregular MENSTRUAL CYCLE and widely fluctuated hormone levels. They may appear 6 years before menopause and subside 2 to 5 years after menopause.

Top Publications

  1. ncbi Clinical study comparing the effects of sequential hormone replacement therapy with oestradiol/dydrogesterone and conjugated equine oestrogen/norgestrel on lipids and symptoms
    Diana Cieraad
    Solvay Pharmaceuticals BV, Weesp, The Netherlands
    Arch Gynecol Obstet 274:74-80. 2006
  2. ncbi Attribution of menopause symptoms in human immunodeficiency virus-infected or at-risk drug-using women
    Tonya M Johnson
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA
    Menopause 15:551-7. 2008
  3. pmc Cognition in perimenopause: the effect of transition stage
    MIRIAM T WEBER
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Menopause 20:511-7. 2013
  4. ncbi Perimenopause and depression: strength of association, causal mechanisms and treatment recommendations
    M Elizabeth Gyllstrom
    Division of Epidemiology and Community Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA
    Best Pract Res Clin Obstet Gynaecol 21:275-92. 2007
  5. ncbi Cycle and hormone changes during perimenopause: the key role of ovarian function
    Henry G Burger
    Prince Henry s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia
    Menopause 15:603-12. 2008
  6. ncbi The perimenopause and sexual functioning
    Nancy E Avis
    Department of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Obstet Gynecol Clin North Am 38:587-94. 2011
  7. ncbi Characterization of cyclicity and hormonal profile with impending ovarian failure in a novel chemical-induced mouse model of perimenopause
    Jessica C Lohff
    The Department of Physiology, College of Medicine, The University of Arizona, Tucson, Arizona, USA
    Comp Med 55:523-7. 2005
  8. ncbi Symptoms during the perimenopause: prevalence, severity, trajectory, and significance in women's lives
    Nancy Fugate Woods
    Department of Family and Child Nursing, University of Washington, Seattle, Washington 98195 7260, USA
    Am J Med 118:14-24. 2005
  9. pmc Perimenopause and cognition
    Gail A Greendale
    Division of Geriatrics, David Geffen School of Medicine at UCLA, 10945 Le Conte Avenue, Los Angeles, CA 90095 1687, USA
    Obstet Gynecol Clin North Am 38:519-35. 2011
  10. pmc Sex hormones and mood in the perimenopause
    Peter J Schmidt
    Behavioral Endocrinology Branch, National Institute of Mental Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Ann N Y Acad Sci 1179:70-85. 2009

Detail Information

Publications234 found, 100 shown here

  1. ncbi Clinical study comparing the effects of sequential hormone replacement therapy with oestradiol/dydrogesterone and conjugated equine oestrogen/norgestrel on lipids and symptoms
    Diana Cieraad
    Solvay Pharmaceuticals BV, Weesp, The Netherlands
    Arch Gynecol Obstet 274:74-80. 2006
    ..A clinical study comparing the effects of sequential hormone replacement therapy with oestradiol/dydrogesterone and conjugated equine oestrogen/norgestrel on lipids and symptoms...
  2. ncbi Attribution of menopause symptoms in human immunodeficiency virus-infected or at-risk drug-using women
    Tonya M Johnson
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA
    Menopause 15:551-7. 2008
    ..To examine the relationship of human immunodeficiency virus (HIV) and attribution of menopausal symptoms...
  3. pmc Cognition in perimenopause: the effect of transition stage
    MIRIAM T WEBER
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Menopause 20:511-7. 2013
    ..stages of reproductive aging and to evaluate whether hormones or menopausal symptoms predict cognition in perimenopause. We hypothesized that women in late menopausal transition and early postmenopause would perform more poorly ..
  4. ncbi Perimenopause and depression: strength of association, causal mechanisms and treatment recommendations
    M Elizabeth Gyllstrom
    Division of Epidemiology and Community Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA
    Best Pract Res Clin Obstet Gynaecol 21:275-92. 2007
    b>Perimenopause represents a significant transition in a woman's life...
  5. ncbi Cycle and hormone changes during perimenopause: the key role of ovarian function
    Henry G Burger
    Prince Henry s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia
    Menopause 15:603-12. 2008
    ..There is no specific endocrine marker of the early or late transition, making measurements of FSH or E2 unreliable in attempting to stage an individual with regard to approaching menopause...
  6. ncbi The perimenopause and sexual functioning
    Nancy E Avis
    Department of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Obstet Gynecol Clin North Am 38:587-94. 2011
    ..article covers cross-sectional and longitudinal community-based research on sexual functioning during the perimenopause. .The.article addresses the relative contributions of perimenopause and other.factors (e.g...
  7. ncbi Characterization of cyclicity and hormonal profile with impending ovarian failure in a novel chemical-induced mouse model of perimenopause
    Jessica C Lohff
    The Department of Physiology, College of Medicine, The University of Arizona, Tucson, Arizona, USA
    Comp Med 55:523-7. 2005
    ..The period between loss of these follicles and ovarian failure is analogous to perimenopause in women...
  8. ncbi Symptoms during the perimenopause: prevalence, severity, trajectory, and significance in women's lives
    Nancy Fugate Woods
    Department of Family and Child Nursing, University of Washington, Seattle, Washington 98195 7260, USA
    Am J Med 118:14-24. 2005
    ..the menopausal transition that address the following questions: (1) Which symptoms do women report during the perimenopause, and how prevalent are these symptoms as women traverse the menopausal transition? (2) How severe are symptoms ..
  9. pmc Perimenopause and cognition
    Gail A Greendale
    Division of Geriatrics, David Geffen School of Medicine at UCLA, 10945 Le Conte Avenue, Los Angeles, CA 90095 1687, USA
    Obstet Gynecol Clin North Am 38:519-35. 2011
    The impact of perimenopause on cognition seems to be characterized by an absence of improved scores rather than a decline...
  10. pmc Sex hormones and mood in the perimenopause
    Peter J Schmidt
    Behavioral Endocrinology Branch, National Institute of Mental Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Ann N Y Acad Sci 1179:70-85. 2009
    ..Thus, although depression is not a uniform accompaniment of the menopause transition, in some women, age-related changes in ovarian estrogen production may alter central nervous system function and predispose them to develop depression...
  11. pmc Longitudinal analysis of the association between vasomotor symptoms and race/ethnicity across the menopausal transition: study of women's health across the nation
    Ellen B Gold
    Division of Epidemiology, Department of Public Health Sciences, University of California, Davis, CA 95616, USA
    Am J Public Health 96:1226-35. 2006
    ..We also sought to determine whether racial/ethnic differences were explained by sociodemographic, health, or lifestyle factors...
  12. ncbi Self-reported anxiety, depressive, and vasomotor symptoms: a study of perimenopausal women presenting to a specialized midlife assessment center
    Andreea L Seritan
    Department of Psychiatry and Behavioral Sciences, University of California, Davis, Medical Center, Sacramento, CA, USA
    Menopause 17:410-5. 2010
    ..The aim of this study was to examine the association of vasomotor symptoms (VMS) with anxiety and/or depressive symptoms in perimenopausal women...
  13. ncbi Understanding the pathophysiology of vasomotor symptoms (hot flushes and night sweats) that occur in perimenopause, menopause, and postmenopause life stages
    D C Deecher
    Women s Health Research, Wyeth Pharmaceuticals, Collegeville, PA 19426, USA
    Arch Womens Ment Health 10:247-57. 2007
    ..This review considers the processes and pathways involved in normal temperature regulation and the impact of fluctuating and declining hormones that result in VMS during the menopausal transition...
  14. ncbi Associations of hormones and menopausal status with depressed mood in women with no history of depression
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Arch Gen Psychiatry 63:375-82. 2006
    ..Whether depressed mood reported in the transition to menopause by women with no history of depression is associated with menopausal status and changes in reproductive hormones is controversial and lacks scientific information...
  15. ncbi Relation of daily urinary hormone patterns to vasomotor symptoms in a racially/ethnically diverse sample of midlife women: study of women's health across the nation
    Ellen B Gold
    Division of Epidemiology, Department of Public Health Sciences, School of Medicine, University of California, Davis, CA 95616, USA
    Reprod Sci 14:786-97. 2007
    ..ovulatory activity according to the work of Kassam et al, VMS are significantly associated with obesity, early perimenopause, and increasing PdG levels...
  16. ncbi Endogenous hormones and bone turnover markers in pre- and perimenopausal women: SWAN
    M R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Osteoporos Int 14:191-7. 2003
    ..In these pre- and early perimenopausal women, higher FSH concentrations, but not other serum reproductive hormone concentrations, are positively associated with greater bone turnover prior to the last menstrual period...
  17. ncbi Eszopiclone in patients with insomnia during perimenopause and early postmenopause: a randomized controlled trial
    Claudio N Soares
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada, and Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
    Obstet Gynecol 108:1402-10. 2006
    ..To evaluate eszopiclone 3 mg for treatment of insomnia in perimenopausal and early postmenopausal women, as well as the impact of insomnia treatment on mood, menopause-related symptoms, and quality of life...
  18. ncbi Detection of perimenopause or postmenopause human chorionic gonadotropin: an unnecessary source of alarm
    Laurence A Cole
    USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico Albuquerque, NM, USA
    Am J Obstet Gynecol 198:275.e1-7. 2008
    ..We describe the problem and a concise approach to this management dilemma in menopausal women...
  19. ncbi Symptom clusters during the late menopausal transition stage: observations from the Seattle Midlife Women's Health Study
    Lori Cray
    Department of Family and Child Nursing, University of Washington, Seattle, WA 98016, USA
    Menopause 17:972-7. 2010
    ..The aims of this study were to identify groups of women in the late menopausal transition stage who experienced the same cluster of symptoms and to identify indicators that predicted membership in these distinct groups...
  20. ncbi Training or EPT in perimenopause on balance and flushes
    Ingrid Bergström
    Center for Endocrinology, Metabolism and Diabetes, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Acta Obstet Gynecol Scand 86:467-72. 2007
    ..The study period was 18 months. Postural stability was measured every third month using a custom-made force platform. The women using EPT achieved better results in 3 of 6 parameters, after 18 months...
  21. ncbi Perimenopause: more than hot flushes and night sweats for some Australian women
    Carol McVeigh
    Massey University, Wellington Campus, Private Box 756, Wellington New Zealand
    J Obstet Gynecol Neonatal Nurs 34:21-7. 2005
    ..To identify the most common perimenopausal symptoms experienced by a group of Australian women and explore the extent to which those symptoms were distressing...
  22. ncbi Effect of duration of dosing on onset of ovarian failure in a chemical-induced mouse model of perimenopause
    Jessica C Lohff
    Department of Physiology, The University of Arizona, Tucson, AZ 85724, USA
    Menopause 13:482-8. 2006
    ..As a result, the animal undergoes ovarian failure, but retains residual ovarian tissue. The purpose of this study was to use a mouse model to regulate the induction of a period analogous to perimenopause in women.
  23. ncbi Association of serum undercarboxylated osteocalcin with serum estradiol in pre-, peri- and early post-menopausal women
    T Yasui
    Department of Obstetrics and Gynecology, School of Medicine, University of Tokushima, Tokushima 770 8503, Japan
    J Endocrinol Invest 29:913-8. 2006
    ....
  24. ncbi Relation between homocysteine and biochemical bone turnover markers and bone mineral density in peri- and post-menopausal women
    Markus Herrmann
    Abteilung für Klinische Chemie und Laboratoriumsmedizin Zentrallabor, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Chem Lab Med 43:1118-23. 2005
    ..Therefore, it is tempting to speculate that Hcy adversely affects bone metabolism. This study aimed to analyze the relation between Hcy and biochemical markers of bone metabolism and bone mineral density (BMD)...
  25. ncbi [Guidelines for hormone treatment of women in the menopausal transition and beyond: position statement by the Executive Committee of the International Menopause Society]
    F Naftolin
    Lijec Vjesn 127:94-6. 2005
  26. ncbi Parameters of bladder function in pre-, peri-, and postmenopausal continent women without detrusor overactivity
    Mathias H D Pfisterer
    Bethanien Krankenhaus Geriatrisches Zentrum Kontinenzberatungsstelle, Rohrbacherstrasse 149, Heidelberg, Germany
    Neurourol Urodyn 26:356-61. 2007
    ..To determine normative data for lower urinary tract function in asymptomatic continent women without detrusor overactivity (DO) across the age span...
  27. ncbi A tale of two studies: the importance of setting, subjects and context in two randomized, controlled trials of a web-based decision support for perimenopausal and postmenopausal health decisions
    Barry G Saver
    Department of Family Medicine and Community Health, University of Massachusetts Medical School, 55 Lake Avenue North, Benedict Building, Worcester, MA 01655, USA
    Patient Educ Couns 66:211-22. 2007
    ..Web-based decision supports can be rapidly updated and have the potential to improve the quality of patients' decisions. We developed and tested a web-based decision support for peri- and postmenopausal health decisionmaking...
  28. ncbi Physical activity and risk of hot flashes among women in midlife
    Brian W Whitcomb
    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Womens Health (Larchmt) 16:124-33. 2007
    ....
  29. ncbi Estrogens and cerebrovascular stroke: what do animal models teach us?
    Phyllis M Wise
    Department of Neurobiology, Physiology, and Behavior, Division of Biological Sciences, One Shields Ave, University of California Davis, Davis, CA 95616, USA
    Ann N Y Acad Sci 1052:225-32. 2005
    ..We will review data, predominantly from our laboratory, gathered over the past six years that lead us to this conclusion...
  30. ncbi Genotypes of vitamin D and estrogen receptors in pre and perimenopausal women from Cordoba, Argentina
    Maria Ulla
    Centro de Endocrinología, Osteologia y Metabolismo, Universidad Nacional de Cordoba, Cordoba, Argentina
    Medicina (B Aires) 67:32-8. 2007
    ....
  31. ncbi High bone mineral density among perimenopausal women
    Janne Pesonen
    Bone and Cartilage Research Unit, Clinical Research Center, University of Kuopio, P O Box 1627, 70211, Kuopio, Finland
    Osteoporos Int 16:1899-906. 2005
    ..We suggest that the fracture risk is low in these women, and thus they are neither primary candidates for BMD screening nor for osteoporosis medication...
  32. ncbi [Bone metabolism, bone density and estrogen levels in perimenopause: a prospective 2-year-study]
    V Seifert-Klauss
    Frauenklinik und Poliklinik der TU München
    Zentralbl Gynakol 127:132-9. 2005
    ..Bone metabolism markers were highest in the postmenopausal group. Perimenopause was associated with a gradual rise in OC, PYD and CTX...
  33. ncbi Association of serum cytokine concentrations with psychological symptoms in midlife women
    Toshiyuki Yasui
    Department of Obstetrics and Gynecology, Course of Human Development, Human Development and Health Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto, Tokushima, Japan
    J Reprod Immunol 75:56-62. 2007
    ..The purpose of the present study was to clarify the association of serum cytokine concentrations, determined using a multiplexed cytokine assay, with psychological symptoms in midlife women...
  34. ncbi Influence of pattern of menopausal transition on the amount of trabecular bone loss. Results from a 6-year prospective longitudinal study
    V Seifert-Klauss
    Frauenklinik und Poliklinik, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Str 22, 81675 Munchen, Germany
    Maturitas 55:317-24. 2006
    ..This study sought to characterize the dynamics of changes leading to postmenopausal osteopenia and to possibly find the time point at which accelerated bone loss begins...
  35. ncbi Climacteric medicine: European Menopause and Andropause Society (EMAS) 2004/2005 position statements on peri- and postmenopausal hormone replacement therapy
    Sven O Skouby
    Frederiksberg Hospital, Department of Ob Gyn, 2000 Copenhagen F, Denmark
    Maturitas 51:8-14. 2005
    ..In contrast, urogenital symptoms may be addressed efficiently and safely with long-term local estrogen therapy...
  36. ncbi Severe hot flashes are associated with chronic insomnia
    Maurice M Ohayon
    Stanford Sleep Epidemiology Research Center, Stanford University School of Medicine, 3430 W Bayshore Road, Palo Alto, CA 94303, USA
    Arch Intern Med 166:1262-8. 2006
    ....
  37. ncbi Effects of melatonin in perimenopausal and menopausal women: our personal experience
    G Bellipanni
    Menopause Center, Madonna della Grazie Health Institute, Via Salvo D Acquisto 67, 00049 Velletri Rome, Italy
    Ann N Y Acad Sci 1057:393-402. 2005
    ..and that a relationship exists between adenohypophyseal and steroid hormones and MEL during the ovarian cycle, perimenopause, and menopause. Subjects took a daily dose of 3 mg synthetic melatonin or a placebo for 6 months...
  38. pmc Effect of oral contraceptives and hormone replacement therapy on bone mineral density in premenopausal and perimenopausal women: a systematic review
    S L Liu
    Queen s University, Kingston, Ontario, Canada
    Br J Sports Med 40:11-24. 2006
    ..The ideal formulation(s) and duration of treatment remain to be determined by further longitudinal and prospective randomised controlled trials in larger subject populations...
  39. ncbi Estrogen therapy selectively enhances prefrontal cognitive processes: a randomized, double-blind, placebo-controlled study with functional magnetic resonance imaging in perimenopausal and recently postmenopausal women
    Hadine Joffe
    Women s Center for Behavioral Endocrinology, McLean Hospital, Harvard Medical School, Boston, MA, USA
    Menopause 13:411-22. 2006
    ....
  40. ncbi Acupuncture for hot flashes: a randomized, sham-controlled clinical study
    Ann Vincent
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Menopause 14:45-52. 2007
    ....
  41. ncbi Menstrual cycle lengths and bone mineral density: a cross-sectional, population-based study in rural Chinese women ages 30-49 years
    F Ouyang
    The Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Chicago, IL, USA
    Osteoporos Int 18:221-33. 2007
    ..The menstrual cycle involves periodic fluctuations in estrogen and progesterone levels. Longer cycles have been associated with longer follicular phase, delayed estrogen peak and a lower mean oestradiol level of the entire cycle...
  42. ncbi Serum follicle stimulating hormone and estradiol in peri/postmenopausal women attending Siriraj Menopause Clinic: a retrospective study
    Surasak Angsuwathana
    Gynecologic Endocrinology Unit, Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Med Assoc Thai 89:1101-8. 2006
    ..To determine serum levels of Follicle Stimulating Hormone (FSH) and Estradiol (E) in peri/postmenopausal women attending the menopause clinic...
  43. ncbi Association of interleukin-8 with hot flashes in premenopausal, perimenopausal, and postmenopausal women and bilateral oophorectomized women
    Toshiyuki Yasui
    Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770 8503, Japan
    J Clin Endocrinol Metab 91:4805-8. 2006
    ..The purpose of this study was to identify serum cytokine concentrations in premenopausal, perimenopausal, and postmenopausal women and bilateral oophorectomized women with hot flashes...
  44. ncbi Escitalopram versus ethinyl estradiol and norethindrone acetate for symptomatic peri- and postmenopausal women: impact on depression, vasomotor symptoms, sleep, and quality of life
    Claudio N Soares
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Menopause 13:780-6. 2006
    ..To examine the efficacy and tolerability of escitalopram (ESCIT) compared to estrogen and progestogen therapy (EPT) for the treatment of symptomatic peri- and postmenopausal women...
  45. ncbi Sexual dysfunction in the peri- and postmenopause. Status of incidence, pharmacological treatment and possible risks. A secondary publication
    Nina Gregersen
    Department of Urology, Aalborg Hospital, Aarhus University Hospital, Denmark
    Dan Med Bull 53:349-53. 2006
    ..There are only a limited number of well-conducted population surveys on the prevalence of FSD. Further, relatively few randomized, controlled trials of pharmacological treatment of FSD have been carried out...
  46. ncbi What is the influence of weight change on forearm bone mineral density in peri- and postmenopausal women? The health study of Nord-Trondelag, Norway
    Siri Forsmo
    Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway
    Am J Epidemiol 164:890-7. 2006
    ..No independent association between weight gain and forearm BMD was found...
  47. ncbi [Caring for women during perimenopause in the practice]
    M J Beckermann
    Frauenärztliche Gemeinschaftspraxis, Koln
    Ther Umsch 62:813-20. 2005
    ..Alternative and complementary medical treatments must prove they are more effective than placebo especially, in particular as long as the risks are insufficiently evaluated...
  48. ncbi [Menopause - facts and controversies]
    Tomasz Pertynski
    Department of Gynecology and Menopausal Diseases, Polish Mother Memorial Hospital, Research Institute, Lodz, Poland
    Endokrynol Pol 57:525-34. 2006
    ..This article is focused also on some controversial topics concerning the HT action on breast, coronary system and brain...
  49. ncbi Steroid sulfatase in breast carcinoma and change of serum estrogens levels after operation
    Yuko Tsunoda
    Second Department of Surgery, School of Medicine, Showa University, Tokyo, Japan
    Acta Oncol 45:584-9. 2006
    ....
  50. ncbi Limitations of follicle-stimulating hormone in assessing menopause status: findings from the National Health and Nutrition Examination Survey (NHANES 1999-2000)*
    Janet B Henrich
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8025, USA
    Menopause 13:171-7. 2006
    ....
  51. ncbi Association between menopause status and central adiposity measured at different cutoffs of waist circumference and waist-to-hip ratio
    Giovana B Donato
    Postgraduate Program in Medicine Medical Sciences, School of Medicine, Federal University of Rio Grande do Sul, RS, Brazil
    Menopause 13:280-5. 2006
    ..To assess the association between menopause status and central adiposity measured using two different cutoffs of waist circumference and waist-to-hip ratio, while controlling for body mass index and other confounding factors...
  52. ncbi Menopause, estrogens, progestins, or their combination on body weight and anthropometric measures
    Angelo Cagnacci
    Department of Obstetrics Gynecology and Pediatrics, University of Modena, Modena, Italy
    Fertil Steril 88:1603-8. 2007
    ..To evaluate modification in body weight and anthropometric indexes in women at the time of menopause...
  53. ncbi Sleep disturbance in menopause
    Robert R Freedman
    Department of Psychiatry, Wayne State University School of Medicine, and Henry Ford Hospital Sleep Disorders Center, Detroit, MI 48201, USA
    Menopause 14:826-9. 2007
    ..To determine the sources of sleep complaints in peri- and postmenopausal women reporting disturbed sleep...
  54. ncbi Correlation of endometrial thickness, cycle day and histopathology in women with abnormal uterine bleeding
    Lovina S Machado
    Department of Obstetrics and Gynecology, Sultan Qaboos University Hospital, Al Khod, PO Box 38, Code 123, Muscat, Sultanate of Oman
    Saudi Med J 26:260-3. 2005
    ....
  55. ncbi Menopausal transition and depression: who is at risk and how to treat it?
    Claudio N Soares
    Women s Health Concerns Clinic, St Joseph s Healthcare Hamilton, 301 James St South, FB number 638, Hamilton, ON L8P 3B6, Canada
    Expert Rev Neurother 7:1285-93. 2007
    ..Hormonal and nonhormonal factors that may contribute to the occurrence of physical and/or psychiatric complaints during the menopausal transition are discussed. Lastly, existing evidence-based treatment strategies are summarized...
  56. ncbi Ultrasonometric profiling of incidence and risk of osteoporosis on rural women
    Sarah H Gueldner
    Institute for Primary and Preventative Health Care, Decker School of Nursing, State University of New York, Binghamton, New York 13902, USA
    Conf Proc IEEE Eng Med Biol Soc 1:5204-5. 2006
    ..038) than those who had not. That approximately 25% of this sample has low bone mass or osteoporosis underscores the importance of early screening in order to develop awareness and provide education on bone health management...
  57. ncbi Childhood cod liver oil consumption and bone mineral density in a population-based cohort of peri- and postmenopausal women: the Nord-Trondelag Health Study
    Siri Forsmo
    Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway
    Am J Epidemiol 167:406-11. 2008
    ....
  58. ncbi Elevated plasma leptin levels associated with high blood pressure and TG rich lipoproteins but not associated with plasma gonadotropins, estradiol and cortisol levels in peri- and postmenopausal lean women with undefined symptoms
    T Ushiroyama
    Department of Obstetrics and Gynecology, Osaka Medical College, Takatsuki, Osaka 569 8686, Japan
    J Med 35:63-73. 2004
    ..It is suggested that leptin may play an important role in physiological regulation of sympathetic nervous system and lipid metabolism in peri-and postmenopausal women...
  59. ncbi Frequency and severity of vasomotor symptoms among peri- and postmenopausal women in the United States
    R E Williams
    Worldwide Epidemiology, GlaxoSmithKline, Research Triangle Park, NC 27709 3398, USA
    Climacteric 11:32-43. 2008
    ..To describe characteristics of vasomotor symptoms, specifically daily frequency and severity, among women 40-65 years old in the United States (US)...
  60. pmc Abdominal adiposity and hot flashes among midlife women
    Rebecca C Thurston
    From the 1Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15217, USA
    Menopause 15:429-34. 2008
    ..The study objective was to examine associations between abdominal adiposity and hot flashes, including the role of reproductive hormones in these associations...
  61. ncbi Mental workload under time pressure can trigger frequent hot flashes in menopausal women
    Mi Kyong Park
    Department of Ergonomics, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, Fukuoka 807 8555, Japan
    Ind Health 46:261-8. 2008
    ....
  62. ncbi Symptoms in peri- and postmenopausal women in relation to testosterone concentrations: data from The Women's Health in the Lund Area (WHILA) study
    A Gotmar
    Department of Molecular and Clinical Medicine, Division of Obstetrics and Gynecology, Faculty of Health Sciences, University Hospital Linkoping
    Climacteric 11:304-14. 2008
    ..The aim of this study was to investigate possible associations between androgen concentrations in perimenopausal women and symptoms that may be associated with low androgen concentrations in the blood...
  63. ncbi Fracture risk and bone density of peri- and early postmenopausal women with uterine leiomyomas
    Kaisa M Randell
    Department of Obstetrics and Gynecology, Kuopio University Hospital, P O Box 1777, FIN 70211 Kuopio, Finland
    Maturitas 53:333-42. 2006
    ..Fracture risk and bone mineral density (BMD) among peri- and early postmenopausal women with leiomyomas requiring hysterectomy was evaluated...
  64. ncbi Cathepsin K predicts femoral neck bone mineral density change in nonosteoporotic peri- and early postmenopausal women
    Janez Prezelj
    Department of Endocrinology and Metabolic Diseases, Biomedica Group, Vienna, Austria
    Menopause 15:369-73. 2008
    ..The secondary end points were the correlations of serum cathepsin K with cross-sectional BMD and with other serum bone turnover markers and age...
  65. ncbi New progestogens: a review of their effects in perimenopausal and postmenopausal women
    Regine Sitruk-Ware
    Rockefeller University and Population Council, New York, New York, USA
    Drugs Aging 21:865-83. 2004
    ....
  66. ncbi Emotional antecedents of hot flashes during daily life
    Rebecca C Thurston
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Durham, North Carolina, USA
    Psychosom Med 67:137-46. 2005
    ..It also examined individual differences predicting concordance between objective and subjective hot flashes...
  67. ncbi Influence of different HRT regimens on mammographic density
    Hans Junkermann
    Ruprecht Karls Universitat Heidelberg, Universitats Frauenklinik, Abteilung für Gynäkologische Radiologie, Heidelberg, Germany
    Maturitas 50:105-10. 2005
    ..A prospective, randomized, open-label study was conducted to evaluate effects on mammographic density in postmenopausal and late perimenopausal women receiving continuous combined or sequential combined hormone replacement therapy (HRT)...
  68. ncbi Phytochemical intake and relationship to past health history in Japanese women
    Melissa K Melby
    Laboratory of Public Health Nutrition and Epidemiology, Department of Applied BioSciences, Tokyo University of Agriculture, Setagaya, Japan
    Biofactors 22:265-9. 2004
    ..Fourteen of 17 FFF factors, as well as age, BMI and menopausal status, exhibited both positive and negative correlations with past history of hypertension, diabetes, allergy, migraine, and menopausal syndrome...
  69. ncbi [Peri-menopausal and post-menopausal experience among women with and without hormone replacement therapy]
    Sônia Maria Garcia Vigeta
    Departamento de Enfermagem, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Cad Saude Publica 20:1682-9. 2004
    ..The article suggests the importance of training health professionals to understand the peri-menopausal and post-menopausal periods as part of the aging process, and thus as a vital rather than pathological process...
  70. ncbi The association between mammographic breast density and bone mineral density in the study of women's health across the nation
    Carolyn J Crandall
    David Geffen School of Medicine at University of California, Los Angeles, CA 90024, USA
    Ann Epidemiol 17:575-83. 2007
    ..Bone mineral density and mammographic breast density are each associated with markers of lifetime estrogen exposure. The association between mammographic breast density and bone mineral density in early perimenopausal women is unknown...
  71. ncbi Effect of supplementation of calcium and vitamin D on bone mineral density and bone mineral content in peri- and post-menopause women; a double-blind, randomized, controlled trial
    Nicola Di Daniele
    Human Nutrition Unit, Via Montpellier 1, University of Rome, Tor Vergata, 00173 Rome, Italy
    Pharmacol Res 50:637-41. 2004
    ..Osteoporosis is a serious global health problem for the future, that is why improving diagnostic methods and prevention of this disease could be helpful...
  72. ncbi Genetic effects on bone loss in peri- and postmenopausal women: a longitudinal twin study
    Joanna Makovey
    Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Sydney, Australia
    J Bone Miner Res 22:1773-80. 2007
    ..Results of genetic model-fitting analysis indicated genetic effects on bone loss account for approximately 40% of the between-individual variation in bone loss at the lumbar spine, forearm, and whole body...
  73. ncbi [Comparison of different antidepression therapy in perimenopausal and postmenopausal women with depression]
    Ai luan Lai
    Department of Obstetrics and Gynecology, Affiliated Fuxing Hospital, Capital University of Medical Science, Beijing 100038, China
    Zhonghua Fu Chan Ke Za Zhi 42:169-72. 2007
    ..To study the effects of antidepression drugs and hormone replacement therapy (HRT) in perimenopausal and postmenopausal women with depression...
  74. ncbi The normal menopause transition
    S M McKinlay
    New England Research Institute, Watertown, Massachusetts 02172
    Maturitas 14:103-15. 1992
    ..8 years) between current smokers and non-smokers. The new analyses reported here on median age at inception of perimenopause (47...
  75. ncbi New women-specific diagnostic modules: the Composite International Diagnostic Interview for Women (CIDI-VENUS)
    Julia Martini
    Technische Universitat Dresden, Dresden, Germany
    Arch Womens Ment Health 12:281-9. 2009
    ..Dysphoric Disorder (PMDD), psychiatric disorders during pregnancy and postpartum as well as during the perimenopause, menopause and beyond are not addressed by the standard CIDI diagnostic modules...
  76. ncbi Premature ovarian failure in women with epilepsy
    P Klein
    Department of Neurology, Georgetown University Hospital, Washington, DC 20007, USA
    Epilepsia 42:1584-9. 2001
    ..The incidence of premature ovarian failure (POF) in women with epilepsy has not been systematically studied. This study examined the incidence of POF in women with epilepsy...
  77. ncbi Comparison of norgestrel- versus cyproterone acetate-containing hormone replacement therapy on lipid-lipoprotein metabolism
    K Panyakhamlerd
    Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    J Med Assoc Thai 83:764-70. 2000
    ..Sixty-four healthy women in their perimenopause or early postmenopause, aged between 40-55 years, were randomized to one of the two 21-day sequential regimens:..
  78. ncbi Effect of vitamin D receptor and estrogen receptor gene polymorphism on the relationship between dietary calcium and bone mineral density in Japanese women
    Takumi Kurabayashi
    Department of Obstetrics and Gynecology, Niigata University School of Medicine, 1 757 Asahimachi dori, 951 8510, Niigata, Japan
    J Bone Miner Metab 22:139-47. 2004
    ..divided into three groups: (i) premenopause, women who were at least 5 years preceding menopause; (ii) perimenopause, women who were within 5 years before or after menopause; and (iii) postmenopause, women who were at least 5 ..
  79. ncbi Comparison of the effectiveness of venlafaxine in peri- and postmenopausal patients with major depressive disorder
    C Iglesias Garcia
    Psychiatry Department, Hospital Valle del Nalon, Langreo, Asturias, Spain
    Actas Esp Psiquiatr 38:326-31. 2010
    ....
  80. pmc Progesterone and ovulation across stages of the transition to menopause
    KATHLEEN A O'CONNOR
    Department of Anthropology, University of Washington, Seattle, WA 98195, USA
    Menopause 16:1178-87. 2009
    ..Detailed characterization of progesterone and ovulation across the menopausal transition provides insight into conception risk and mechanisms of reproductive aging...
  81. ncbi [Management of menopause in primary health care]
    Luís Filipe Cavadas
    Serviço de Medicina Geral e Familiar, Unidade Local de Saúde de Matosinhos, Matosinhos
    Acta Med Port 23:227-36. 2010
    ..It is essential for the GP to know how to properly approach women at this stage of their life and how to provide them the best support...
  82. ncbi [Antigonadotropic effects of a 19-nor-progesterone derivative: the example of nomegestrol acetate]
    C Jamin
    Service de Gynecologie Obstetrique, Hopital Bichat Claude Bernard, 46, rue Henri Huchard, 75018, Paris, France
    Gynecol Obstet Fertil 31:70-81. 2003
    ..particurlarly on the endometrium and enables to treat the frequent clinical hyperestrogenic symptoms of the perimenopause without negative metabolic or hemostatic effects...
  83. ncbi Prevalence and risk factors associated with osteoporosis in women attending menopause clinic at Hat Yai Regional Hospital
    Tapnarong Jarupanich
    Department of Obstetrics and Gynecology, Hat Yai Regional Hospital, Hat Yai, Songkla 90110, Thailand
    J Med Assoc Thai 90:865-9. 2007
    To determine the prevalence and risk factors of osteoporosis with different perimenopause status.
  84. pmc Influence of age and 17beta-estradiol on kisspeptin, neurokinin B, and prodynorphin gene expression in the arcuate-median eminence of female rhesus macaques
    Dominique H Eghlidi
    Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    Endocrinology 151:3783-94. 2010
    ..Nevertheless, they clearly demonstrate that loss of ovarian steroid negative feedback that occurs during perimenopause plays a major role in modulating the activity of KNDy circuits of the aging primate ARC-ME.
  85. ncbi Prevalence of memory loss complaints and other symptoms associated with the menopause transition: a community survey
    Gayatri Devi
    New York Memory and Healthy Aging Services, New York, New York, USA
    Gend Med 2:255-64. 2005
    ..Complaints of memory loss are increasingly noted as part of the constellation of symptoms experienced in the menopause transition. Studies evaluating such complaints in this population have yielded varying results...
  86. ncbi Assessment of reproductive behavior and hormonal cycles in geriatric western Lowland gorillas
    Susan W Margulis
    Chicago Zoological Society, Chicago, Illinois
    Zoo Biol 26:117-39. 2007
    ..These findings suggest that pre-menopausal females are exhibiting signs of perimenopause. As is the case in humans, such changes in hormone patterns may occur years before the onset of menopause...
  87. ncbi Body size and ethnicity are associated with menstrual cycle alterations in women in the early menopausal transition: The Study of Women's Health across the Nation (SWAN) Daily Hormone Study
    Nanette Santoro
    Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology and Women s Health, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Endocrinol Metab 89:2622-31. 2004
    The dynamics of reproductive hormones that characterize the menopausal transition (perimenopause) are incompletely understood, particularly in non-Caucasian women...
  88. ncbi Menopausal status and sleep-disordered breathing in the Wisconsin Sleep Cohort Study
    Terry Young
    Department of Population Health Sciences, University of Wisconsin Madison, Madison, WI 53726 2335, USA
    Am J Respir Crit Care Med 167:1181-5. 2003
    ..The association of premenopause, perimenopause, and postmenopause with sleep-disordered breathing was investigated with a population-based sample of 589 ..
  89. pmc Change in adipocytokines and ghrelin with menopause
    MaryFran R Sowers
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, United States
    Maturitas 59:149-57. 2008
    ....
  90. pmc Circulating dehydroepiandrosterone sulfate concentrations during the menopausal transition
    Sybil Crawford
    Center for Health and the Environment, University of California at Davis, 1 Shields Avenue, Davis, CA 95616, USA
    J Clin Endocrinol Metab 94:2945-51. 2009
    ..A previous report from the Study of Women Across the Nation indicated a rise in dehydroepiandrosterone sulfate (DHEAS) during the menopausal transition using data from three annual visits...
  91. ncbi Is this woman perimenopausal?
    Lori A Bastian
    Department of Internal Medicine, Duke University, Durham, NC, USA
    JAMA 289:895-902. 2003
    b>Perimenopause is a time of transition for women at midlife. Women want to know whether they are starting this change and physicians need to know the accuracy of a clinical examination in identifying perimenopausal women...
  92. ncbi Use of complementary and alternative medicine during the menopause transition: longitudinal results from the Study of Women's Health Across the Nation
    Yali A Bair
    Planned Parenthood Affiliates of California, Sacramento, CA, USA
    Menopause 15:32-43. 2008
    ..This study examined whether use of complementary and alternative (CAM) therapies during the menopause transition varied by ethnicity...
  93. ncbi Effect of reproductive hormones and selective estrogen receptor modulators on mood during menopause
    Claudio N Soares
    Harvard Medical School, MGH Center for Women s Mental Health, Boston, Massachusetts 02114, USA
    Drugs Aging 20:85-100. 2003
    ..particularly the occurrence of premenstrual dysphoria, puerperal depression and depressive symptoms during perimenopause. It has been speculated that sex steroids such as estrogens, progestogens, testosterone and ..
  94. ncbi Gonadotropins and ovarian gonadotropin receptors during the perimenopausal transition period
    K K Vihko
    Medical School, Department of Obstetrics and Gynecology, Tampere University Hospital, Finland
    Maturitas 23:S19-22. 1996
    As an early sign of perimenopause, the menstrual cycles become irregular. Associated with this irregularity, serum gonadotropin levels increase...
  95. ncbi The normal menopause transition
    Sonja M McKinlay
    New England Research Institute, 9 Galen Street, Watertown, Massachusetts 02172, USA
    Maturitas 61:4-16. 2008
    ..8 years) between current smokers and non-smokers. The new analyses reported here on median age at inception of perimenopause (47...
  96. ncbi Effects of exercise practice on the maintenance of radius bone mineral density in postmenopausal women
    Mizuho Nagata
    Graduate School of Decision Science and Technology, Tokyo Institute of Technology
    J Physiol Anthropol Appl Human Sci 21:229-34. 2002
    ..of exercise practice on the radius bone mineral density (BMD) was investigated on 480 women at the age of perimenopause and later...
  97. pmc Migraine in postmenopausal women and the risk of invasive breast cancer
    Robert W Mathes
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 C308, P O Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:3116-22. 2008
    ..Menarche, menses, pregnancy, and perimenopause may carry a different migraine risk conceivably because of fluctuating estrogen levels, and in general, ..
  98. ncbi A prospective population-based study of menopausal symptoms
    L Dennerstein
    Office for Gender and Health, Department of Psychiatry, The University of Melbourne, Parkville, Australia
    Obstet Gynecol 96:351-8. 2000
    ..To identify symptoms that change in prevalence and severity during midlife and evaluate their relationships to menopausal status, hormonal levels, and other factors...
  99. ncbi The influence of estrogen on migraine: a systematic review
    Jan Lewis Brandes
    Department of Neurology, Vanderbilt University School of Medicine, Nashville, Tenn, USA
    JAMA 295:1824-30. 2006
    ..Menstrual migraine affects approximately 50% to 60% of female migraineurs, but knowledge regarding the role of hormones, especially estrogen, appears incomplete...
  100. pmc History of hot flashes and aortic calcification among postmenopausal women
    Rebecca C Thurston
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Menopause 17:256-61. 2010
    ..Interactions with hormone therapy use were examined in an exploratory fashion...
  101. pmc Psychosocial and socioeconomic burden of vasomotor symptoms in menopause: a comprehensive review
    Wulf H Utian
    North American Menopause Society, 5900 Lander Brook Drive, Mayfield Heights, OH 44124, USA
    Health Qual Life Outcomes 3:47. 2005
    ..the initial decline in circulating gonadal hormones; however, night sweats in particular most often begin in perimenopause. The pathogenesis of hot flushes has not yet been fully elucidated, but the circuitry involving estrogen and ..

Research Grants62

  1. BDNF-Estrogen Interactions with Perimenopausal Mood and Cognition
    Elizabeth M Waters; Fiscal Year: 2012
    ..Depression rates rise sharply in women during perimenopause, which is the 7-10 year period before menopause characterized by declining estrogen levels and gradual ..
  2. Depression, Estrogen Replacement, and Cardiovascular Health in the Perimenopause
    David R Rubinow; Fiscal Year: 2013
    ..cardiac autonomic dysregulation, and metabolic disturbance) within the context of E2 withdrawal during the perimenopause. Heightened cardiovascular, neuroendocrine and inflammatory reactivity to stress also define a profile of risk ..
  3. Estrogen: Neuroprotection in the Perimenopause
    Anne M Etgen; Fiscal Year: 2010
    ..These experiments will provide new information on the potential for hormone therapy instituted during the perimenopausal transition to protect the brain from damage due to global ischemia. ..
  4. Lactation Effects on Postnatal Endothelial Function and Vascular Inflammation
    Karen M Grewen; Fiscal Year: 2013
    ..The postpartum period, like the perimenopause, may therefore be a critical period of enhanced risk for inflammatory damage to vascular endothelium...
  5. Postmenopausal Monkey Resource
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2013
    ..follow up studies, which have used natural hormones and shown that indeed, they need to be administered at perimenopause, but the endpoints were limited to one or two systems...
  6. Biological Mechanisms of Vascular Dysfunction with Age and Estrogen Deficiency
    KERRIE MOREAU; Fiscal Year: 2013
    ..R01 AG027678) will extend and expand on research that was responsive to RFA-AG-05-008 "Biology of the Perimenopause: Impact on Health and Aging...
  7. Prepubertal Stress, Windows of Risk &Sex Bias for Affective Disturbance
    C NEILL NEILL EPPERSON; Fiscal Year: 2013
    ..It is well documented that from puberty to the late perimenopause, MOD and several anxiety disorders are more common in females than males...
  8. Role of the Follicle-Depleted Ovary in the Pathogenesis of Chronic Diseases
    Susan E Appt; Fiscal Year: 2012
    ..Two specific gaps in knowledge are: 1) whether or to what extent the perimenopause is a time of accelerated disease progression;and 2) whether the pathobiological changes that have accumulated ..
  9. Defining the Mechanisms of Menopause-Associated Sleep and Mood Disturbances
    Hadine Joffe; Fiscal Year: 2013
    ..Women are at increased risk for insomnia and depression during the perimenopause and early postmenopause...
  10. Hormones and Cognition Over the Lifespan
    MIRIAM T WEBER; Fiscal Year: 2013
    ..The candidate has extensive training and research experience in the neuropsychology of aging, dementia, and perimenopause and clinical trial methodology...
  11. Impact of Endocrine Aging on Brain and Immune Responses
    Farida Sohrabji; Fiscal Year: 2010
    ..irregularly cycling (perimenopause) and reproductive senescent (postmenopause). In Specific Aim 1...
  12. Neurobiology of the Menopausal Transition
    Yolanda R Smith; Fiscal Year: 2010
    ..Recruits will be women aged 40-55 years, stratified into panels representing premenopause, early perimenopause, late perimenopause and natural postmenopause defined by follicle-stimulating hormone levels and menstrual ..
  13. Effects of Chronic Estrogen on TIDA Neurons: Role of Cytokines and NO
    Puliyur S MohanKumar; Fiscal Year: 2010
    b>Perimenopause is one of the most complex and least understood states of a woman's life...
  14. Genetics of Reproductive Senescence
    Marc Tatar; Fiscal Year: 2010
    ..Population and genetic studies of nonhuman primates will enhance how we understand perimenopause - the menopausal transition...
  15. Hot flashes and memory dysfunction in the perimenopause
    MIRIAM T WEBER; Fiscal Year: 2013
    ..VMS;hot flashes and night sweats) are a mechanism for memory changes in the transition from premenopause to perimenopause to postmenopause...
  16. Perimenopause in Brain Aging and Alzheimer's Disease
    Roberta Diaz Brinton; Fiscal Year: 2013
    ..5 million American women between ages of 45 and 55 enter into the perimenopause. Yet to be discovered is the impact perimenopause has on key brain regions involved in cognition and known to ..
  17. Risk for New onset of Depression in Perimenopausal Women
    Daniel Cramer; Fiscal Year: 2009
    ..However, the extent to which the perimenopause represents a time of greater risk for new onset of depression in women with no history of mood disorder is yet ..
  18. MENOPAUSE AND MIDLIFE AGING EFFECTS ON SLEEP DISORDERS
    Terry Young; Fiscal Year: 2006
    ..quantify the risk of insomnia, hypersomnia and diminished sleep quality attributable to early, middle and late perimenopause and post menopause, 4) investigate protective effects of hormone replacement therapy on sleep problems, and 5) ..
  19. OVARIAN ENDOCRINE REGULATION
    HAROLD BEHRMAN; Fiscal Year: 1999
    ..of H202 in the ovary include the life-threatening inflammatory response associated with ovulation of hyperstimulated ovaries and ovarian stromal responses to excess LH that occurs in the perimenopause, and in polycystic ovarian disease.
  20. MENOPAUSE TRANSITION, MENTAL HEALTH, AND ETHNICITY
    Howard Kravitz; Fiscal Year: 2000
    ..SCID assessments of over 1000 women who are beginning or will soon begin the menopause transition into perimenopause. By continuing to collect systematically psychiatric data on a large multi- ethnic cohort we can take ..
  21. MENOPAUSE TRANSITION, MENTAL HEALTH AND ETHNICITY
    Adriana Cordal; Fiscal Year: 2000
    ..SCID assessments of over 1000 women who are beginning or will soon begin the menopause transition into perimenopause. By continuing to collect systematically psychiatric data on a large multi-ethnic cohort we can take advantage ..
  22. BIOLOGICAL BASIS OF THE PERIMENOPAUSE
    DAVID SEIFER; Fiscal Year: 2002
    ....
  23. WOMEN IN TRANSITION: THE CRUCIAL YEARS BEFORE MENOPAUSE
    GERARDINE WURZBURG; Fiscal Year: 2002
    ..proposed project is a preventive health promotion campaign for women 40-55 about the health risks they face in perimenopause and what they can do to decrease mortality rates and increase well being...
  24. COGNITIVE FUNCTION DURING NATURAL MENOPAUSE
    Diane Jacobs; Fiscal Year: 1999
    ..cognitive functioning associated with menopause would be to prospectively follow a cohort of women from early perimenopause through the menopausal transition, thereby detecting symptoms as they evolve, and permitting the ..
  25. A NON-HUMAN PRIMATE MODEL OF NATURAL MENOPAUSE
    ERIKA HONORE; Fiscal Year: 2003
    ..pedigreed colony of more than 250 female baboons to establish a NHP model of naturally occurring perimenopause and menopause...
  26. Nursing Interventions for Symptoms of Perimenopause
    JUDITH BERG; Fiscal Year: 2004
    ....
  27. EXERCISE AND PERIMENOPAUSAL SYMPTOMS: A RANDOMIZED TRIAL
    Suling Li; Fiscal Year: 2000
    ..effect of a 12-week individualized exercise program with a personal trainer on the frequency and distress of perimenopause associated symptoms in women with/without hormone replacement therapy; 3) to evaluate the synergistic effect ..
  28. BIODEMOGRAPHIC MODELS OF REPRODUCTIVE AGING
    Maxine Weinstein; Fiscal Year: 2001
    ..to the experience of the transition, model the effects of hormonal patterns on menstrual bleeding during the perimenopause, and relate features of the transition to the underlying process of follicular depletion...
  29. Multimedia Support for Perimenopausal Women
    Simon Budman; Fiscal Year: 2006
    ..the feasibility of developing an interactive website called Charting the Change: A Woman's Guide to Perimenopause (www.chartingthechange...
  30. Predicting Onset Age and Length of Menopausal Transition
    Daniel Keenan; Fiscal Year: 2003
    ..taken from say a given 40 year-old female, methods will be constructed by which to predict her age of perimenopause onset and its length, and at same time to state whether she is hormonally that of a 40 year-old, or more like ..
  31. Window of Opportunity of Estrogen Therapy for Neuroprotection
    Natalie Rasgon; Fiscal Year: 2009
    ..evidence that estrogen hormone therapy (E/HT) may be neuroprotective for at least some women when used in perimenopause or early menopause, but not in late menopause...
  32. SWAN Sleep Study II - Michigan Center
    MaryFran Sowers; Fiscal Year: 2008
    ..The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. [unreadable] [unreadable] [unreadable]..
  33. Estrogen, Metabolism, Menopause, and Health Outcomes
    MaryFran Sowers; Fiscal Year: 2006
    ..This is a unique opportunity to prospectively integrate lifestyle elements with measures of hormone metabolism pathways into a comprehensive examination of multiple human health effects. ..
  34. Change in Bone, Arthritis, Function: Hormones & Obesity
    MaryFran Sowers; Fiscal Year: 2009
    ....
  35. Functional Status and the Menopause Transition
    MaryFran R Sowers; Fiscal Year: 2010
    ..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men. ..
  36. Reproductive Hormonal Effects of Weight Loss in Women
    Nanette Santoro; Fiscal Year: 2005
    ..Thus, this initial exploration, if positive, would provide the basis for a new line of investigation for the PI into the interactions between reproduction and metabolism. ..
  37. SWAN Sleep Study II-UC Davis/Kaiser site
    Ellen Gold; Fiscal Year: 2008
    ..The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. ..
  38. Acupuncture Treatment for Menopausal Hot Flashes
    Nancy Avis; Fiscal Year: 2005
    ..abstract_text> ..
  39. CAM Use in Midlife Women in Five Ethnic Groups
    Ellen Gold; Fiscal Year: 2005
    ..abstract_text> ..
  40. PHYSIOLOGY OF ESTROGEN'S MOOD EFFECT IN MENOPAUSAL WOMEN
    Hadine Joffe; Fiscal Year: 2007
    ..Such training will lay the foundation for a career of clinical investigation into the physiology of perimenopausal depression and the impact of hot flushes on sleep, mood, and quality-of-life. ..
  41. EPIDEMIOLOGIC STUDY OF THE LATE REPRODUCTIVE YEARS
    Ellen W Freeman; Fiscal Year: 2010
    ..abstract_text> ..
  42. A Secular Change in Menstrual Characteristicis of Adult and Midlife Women?
    Sioban D Harlow; Fiscal Year: 2010
    ....
  43. Biological Rhythms in Postpartum Depression
    Barbara Parry; Fiscal Year: 2009
    ..This study would serve as the basis of future studies in which treatments designed to correct these underlying abnormalities in circadian rhythms, and restore them to those of NC women, thereby would improve mood in DP. ..
  44. CAREER DEVELOPMENT IN WOMEN'S HEALTH RESEARCH AND GENDE*
    Ellen Freeman; Fiscal Year: 2006
    ..The BIRCWH program will track the career trajectories of Scholars and will continue to serve as a resource in terms of career counseling and research advice. [unreadable] [unreadable]..
  45. Probing Premenstrual Dysphoric Disorder with Light
    Barbara Parry; Fiscal Year: 2007
    ..These investigations will provide further insight into the pathophysiology of PMDD and other depressive disorders in women, and serve as a basis for refining light treatment interventions in the future. ..
  46. Sex Steroids & Mammographic Density in the Postmenopause
    Gail Greendale; Fiscal Year: 2007
    ..We will quantify the relations between the hormone and genetic exposures measured in this project and mammographic density (at baseline as well as change in density between baseline and 12 months). ..
  47. The Yoga for Hyperkyphosis Trial
    Gail Greendale; Fiscal Year: 2007
    ..At the end of this phase we will again measure study endpoints to assess whether participants have maintained the physical function achieved at the end of the RCT. ..
  48. Female Hormones and Vision
    Alvin Eisner; Fiscal Year: 2006
    ..abstract_text> ..
  49. SWAN Sleep Study II - Chicago (Rush) Site
    Howard Kravitz; Fiscal Year: 2008
    ..The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. ..
  50. Staging Reproductive Aging in Four Cohorts: Issues of Hormone Use Spotting Bias
    Sioban Harlow; Fiscal Year: 2009
    ..Results will facilitate clinical decision making for women and providers relevant to contraception, symptomatic treatment and preventive therapy. ..
  51. VISUAL ADAPTATION LIMITS AND AGE-RELATED DISEASE
    Alvin Eisner; Fiscal Year: 2002
    ....
  52. Core symptoms and profiles in premenstrual syndrome
    Ellen Freeman; Fiscal Year: 2008
    ..Further information will contribute to improved health care for women in their reproductive years. [unreadable] [unreadable] [unreadable] [unreadable]..
  53. Risk and Predictors of Postpartum Depression
    Lee Cohen; Fiscal Year: 2007
    ..AItshuler, Dr. Hendrick), and the Emory Women's Mental Health Program at Emory University School of Medicine (Dr. Stowe). [unreadable] [unreadable]..
  54. Skeletal Biology and Medicine Conference
    Mone Zaidi; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  55. Mid-life Aging and Urinary Incontinence in a Multi-Ethn*
    L Waetjen; Fiscal Year: 2009
    ..abstract_text> ..
  56. Effects of Botanicals on Cognition in Midlife Women
    Pauline Maki; Fiscal Year: 2005
    ..Recent findings of significant health risks associated with Prempro heighten the need for research into the effects of alternative therapies for menopausal symptoms on cognitive outcomes. ..
  57. FATIGUE, SLEEP AND CIRCADIAN RHYTHMS IN BREAST CANCER
    Sonia Ancoli Israel; Fiscal Year: 2004
    ..Results will provide a scientific basis for future intervention studies, particularly studies with light therapy which can re-synchronize rhythms. ..
  58. CD38/ADP RIBOSYL CYCLASE R0LE IN OSTEOCLAST REGULATION
    Mone Zaidi; Fiscal Year: 2003
    ..Taken together, the studies should provide mechanistic insights into the role of the NAD+/CD38/cADPr/Ca2+ system in osteoclast control. ..
  59. Contributions of sleep/rhythms/fatigue to "chemobrain"
    Sonia Ancoli Israel; Fiscal Year: 2009
    ..The reported phenomena of chemobrain will be examined to see if it is related to the complaint of fatigue or sleep disruptions, both of which are known to contribute to decreases in cognitive functioning. ..