parturition

Summary

Summary: The process of giving birth to one or more offspring.

Top Publications

  1. ncbi A parturition-associated nonsynaptic coherent activity pattern in the developing hippocampus
    Valerie Crepel
    INMED, INSERM, U29, Universite de la Mediterranee, Parc Scientifique de Luminy, BP 13, 13273 Marseille Cedex 09, France
    Neuron 54:105-20. 2007
  2. pmc Evidence for a role for the adaptive immune response in human term parturition
    Nardhy Gomez-Lopez
    Research Direction and Department of Nutrition Research, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City, Mexico
    Am J Reprod Immunol 69:212-30. 2013
  3. ncbi Nuclear progesterone receptors in the human pregnancy myometrium: evidence that parturition involves functional progesterone withdrawal mediated by increased expression of progesterone receptor-A
    Amy A Merlino
    Department of Reproductive Biology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 5034, USA
    J Clin Endocrinol Metab 92:1927-33. 2007
  4. ncbi Are animal models relevant to key aspects of human parturition?
    Bryan F Mitchell
    Department of Obstetrics and Gynecology, Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Regul Integr Comp Physiol 297:R525-45. 2009
  5. ncbi Inflammatory processes in preterm and term parturition
    Inge Christiaens
    Perinatal Research Centre, Departments of Obstetrics and Gynecology, Pediatrics, Physiology, and Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
    J Reprod Immunol 79:50-7. 2008
  6. ncbi Birth preparedness, complication readiness and fathers' participation in maternity care in a northern Nigerian community
    Zubairu Iliyasu
    Department of Community Medicine, Aminu Kano Teaching Hospital and Bayero University Kano, Nigeria
    Afr J Reprod Health 14:21-32. 2010
  7. ncbi Development and psychometric testing of the scales for measuring maternal satisfaction in normal and caesarean birth
    Ilkay Gungor
    Department of Obstetric and Gynaecologic Nursing, Florence Nightingale School of Nursing, Istanbul University, Abide i Hurriyet cad 34381, Sisli, Istanbul, Turkey
    Midwifery 28:348-57. 2012
  8. ncbi Analysis of di-n-butyl phthalate and other organic pollutants in Chongqing women undergoing parturition
    Ji An Chen
    Department of Environmental Hygiene, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China
    Environ Pollut 156:849-53. 2008
  9. pmc Temporal changes in myeloid cells in the cervix during pregnancy and parturition
    Brenda C Timmons
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 182:2700-7. 2009
  10. ncbi Endocrine immune interactions in human parturition
    E Golightly
    University of Edinburgh, Division of Reproductive and Developmental Sciences, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Mol Cell Endocrinol 335:52-9. 2011

Detail Information

Publications348 found, 100 shown here

  1. ncbi A parturition-associated nonsynaptic coherent activity pattern in the developing hippocampus
    Valerie Crepel
    INMED, INSERM, U29, Universite de la Mediterranee, Parc Scientifique de Luminy, BP 13, 13273 Marseille Cedex 09, France
    Neuron 54:105-20. 2007
    ..Therefore, in the developing hippocampus, delivery is an important signal that triggers the first coherent activity pattern, which is silenced by the emergence of synaptic transmission...
  2. pmc Evidence for a role for the adaptive immune response in human term parturition
    Nardhy Gomez-Lopez
    Research Direction and Department of Nutrition Research, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City, Mexico
    Am J Reprod Immunol 69:212-30. 2013
    ..The purpose of this study was to characterize the immunophenotype of choriodecidual leukocytes as well as the expression of inflammatory mediators in human spontaneous parturition at term.
  3. ncbi Nuclear progesterone receptors in the human pregnancy myometrium: evidence that parturition involves functional progesterone withdrawal mediated by increased expression of progesterone receptor-A
    Amy A Merlino
    Department of Reproductive Biology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 5034, USA
    J Clin Endocrinol Metab 92:1927-33. 2007
    We examined whether human parturition involves functional progesterone withdrawal mediated by changes in myometrial expression of progesterone receptors (PRs)-A and -B.
  4. ncbi Are animal models relevant to key aspects of human parturition?
    Bryan F Mitchell
    Department of Obstetrics and Gynecology, Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Regul Integr Comp Physiol 297:R525-45. 2009
    ..Our understanding of the regulation of parturition remains inadequate...
  5. ncbi Inflammatory processes in preterm and term parturition
    Inge Christiaens
    Perinatal Research Centre, Departments of Obstetrics and Gynecology, Pediatrics, Physiology, and Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
    J Reprod Immunol 79:50-7. 2008
    ..In turn, cortisol may drive PG synthesis. Together these feed-forward mechanisms activate the uterus, trigger the production of uterine contractile stimulants and lead to labour and delivery...
  6. ncbi Birth preparedness, complication readiness and fathers' participation in maternity care in a northern Nigerian community
    Zubairu Iliyasu
    Department of Community Medicine, Aminu Kano Teaching Hospital and Bayero University Kano, Nigeria
    Afr J Reprod Health 14:21-32. 2010
    ..There is a need to increase involvement of men in their partner's maternity care through peer-led, culturally-sensitive community education and appropriate health system reforms...
  7. ncbi Development and psychometric testing of the scales for measuring maternal satisfaction in normal and caesarean birth
    Ilkay Gungor
    Department of Obstetric and Gynaecologic Nursing, Florence Nightingale School of Nursing, Istanbul University, Abide i Hurriyet cad 34381, Sisli, Istanbul, Turkey
    Midwifery 28:348-57. 2012
    ..to develop a scale to measure maternal satisfaction with birth to evaluate women's experiences in labour and the early postpartum period...
  8. ncbi Analysis of di-n-butyl phthalate and other organic pollutants in Chongqing women undergoing parturition
    Ji An Chen
    Department of Environmental Hygiene, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China
    Environ Pollut 156:849-53. 2008
    In this study, 40 healthy women from Chongqing undergoing parturition were recruited and samples of venous blood, umbilical cord blood, breast milk and urine were collected for analysis of organic pollutants by GC/MS...
  9. pmc Temporal changes in myeloid cells in the cervix during pregnancy and parturition
    Brenda C Timmons
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 182:2700-7. 2009
    ..sorting were used to determine the role of immune cells in cervical matrix remodeling before, during, and after parturition. Markers of myeloid cell differentiation and activation were assessed to define phenotype and function...
  10. ncbi Endocrine immune interactions in human parturition
    E Golightly
    University of Edinburgh, Division of Reproductive and Developmental Sciences, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Mol Cell Endocrinol 335:52-9. 2011
    Human parturition is an inflammatory event, modulated and influenced by a host of other environmental and physiological processes, including the endocrine hormones...
  11. ncbi Cross-cultural comparison of levels of childbirth-related fear in an Australian and Swedish sample
    Helen Haines
    School of Rural Health The University of Melbourne, 49 Graham St, Shepparton, Victoria, Australia
    Midwifery 27:560-7. 2011
    ..This study aimed to examine the prevalence of CBRF in two rural populations (Sweden and Australia) and to pilot a short, easy-to-administer measurement tool...
  12. ncbi Childbirth fear, anxiety, fatigue, and sleep deprivation in pregnant women
    Wendy A Hall
    University of British Columbia School of Nursing, Vancouver, British Columbia, Canada
    J Obstet Gynecol Neonatal Nurs 38:567-76. 2009
    ..To explore women's levels of childbirth fear, sleep deprivation, anxiety, and fatigue and their relationships during the third trimester of pregnancy...
  13. ncbi Post-traumatic stress disorder due to childbirth: the aftermath
    Cheryl Tatano Beck
    University of Connecticut School of Nursing, 231 Glenbrook Road, Storrs, CT 06269 2026, USA
    Nurs Res 53:216-24. 2004
    ..Childbirth qualifies as an extreme traumatic stressor that can result in post-traumatic stress disorder. The reported prevalence of post-traumatic stress disorder after childbirth ranges from 1.5% to 6%...
  14. ncbi Predictors of women's perceptions of the childbirth experience
    Janet Bryanton
    School of Nursing at the University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada
    J Obstet Gynecol Neonatal Nurs 37:24-34. 2008
    ..To determine the factors that predict women's perceptions of the childbirth experience and to examine whether these vary with the type of birth a woman experiences...
  15. pmc Expression patterns of microRNAs in the chorioamniotic membranes: a role for microRNAs in human pregnancy and parturition
    D Montenegro
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Pathol 217:113-21. 2009
    ..expression in the chorioamniotic membranes and to assess the significance of miRNAs in human pregnancy and parturition. The expression profile of 455 miRNAs was compared between patients at term without labour (TNL: n = 10), in ..
  16. ncbi Role of fetal membranes in signaling of fetal maturation and parturition
    Leslie Myatt
    Dept of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, USA
    Int J Dev Biol 54:545-53. 2010
    ..myometrium, there has been a specific focus on the role of membranes in the initiation and maintenance of parturition. In this review, we summarize the data obtained in our laboratories as well as the data reported in the ..
  17. pmc The facilitating factors and barriers encountered in the adoption of a humanized birth care approach in a highly specialized university affiliated hospital
    Roxana Behruzi
    McGill University, Faculty of Medicine, Department of Family Medicine, Montreal, Canada
    BMC Womens Health 11:53. 2011
    ....
  18. ncbi Is Asian ethnicity an independent risk factor for severe perineal trauma in childbirth? A systematic review of the literature
    Janet Wheeler
    Liverpool Hospital, Sydney South West Area Health Service, Elizabeth Street, Liverpool, NSW, 2170, Australia
    Women Birth 25:107-13. 2012
    ..To undertake a systematic review of the literature to determine whether Asian ethnicity is an independent risk factor for severe perineal trauma in childbirth...
  19. ncbi Evidence for cell proliferation in the sheep brain and its down-regulation by parturition and interactions with the young
    M Brus
    INRA, UMR 85 Physiologie de la Reproduction et des Comportements, Nouzilly, France
    Horm Behav 58:737-46. 2010
    ..In sheep parturition is associated with the establishment of a selective bond with the young based on an olfactory learning...
  20. ncbi A role for lipoxin A4 as anti-inflammatory and proresolution mediator in human parturition
    David Maldonado-Pérez
    Division of Reproductive and Developmental Sciences, University of Edinburgh, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    FASEB J 25:569-75. 2011
    ..was to investigate the role of lipoxin A(4), an anti-inflammatory and proresolution modulator, during human parturition. We measured serum levels of lipoxin A(4) and myometrial protein release using ELISA, quantified lipoxin ..
  21. pmc Intrauterine inflammation, insufficient to induce parturition, still evokes fetal and neonatal brain injury
    Michal A Elovitz
    Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Center for Research in Reproduction and Women s Health, University of Pennsylvania School of Medicine, 421 Curie Blvd, 1354 BRB 2 3, Philadelphia, PA 19104 6142, United States
    Int J Dev Neurosci 29:663-71. 2011
    ..In conclusion, intrauterine inflammation, even in the absence of preterm parturition, can evoke fetal brain injury as evidence by alterations in cytokine expression and neuronal injury...
  22. ncbi Cytokines, prostaglandins and parturition--a review
    J A Keelan
    Liggins Institute, University of Auckland, 2 6 Park Ave, Grafton, New Zealand
    Placenta 24:S33-46. 2003
    ..of these proteins occur with term labour, implicating them as modulators of cytokine actions around the time of parturition. Prostaglandins, released by the membranes in response to stretch and the actions of pro-inflammatory cytokines,..
  23. pmc Cervical remodeling during pregnancy and parturition
    Brenda Timmons
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75235 9032, USA
    Trends Endocrinol Metab 21:353-61. 2010
    ..Recent advances in our understanding of term and preterm cervical remodeling provide new directions for investigation and compel investigators to reevaluate currently accepted models...
  24. ncbi First-time fathers' experiences of childbirth--a phenomenological study
    Asa Premberg
    Institute of Health and Care Sciences, Sahlgrenska Academy at Goteborg University, Box 457, 40530 Goteborg, Sweden
    Midwifery 27:848-53. 2011
    ..To describe fathers' experiences during childbirth...
  25. ncbi Cytokine networks and the regulation of uterine function in pregnancy and parturition
    N M Orsi
    Perinatal Research Group, The YCR and Liz Dawn Pathology and Translational Sciences Centre, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    J Neuroendocrinol 20:462-9. 2008
    ..Further insight into the complexity of cytokine networks will be required to develop novel therapeutic strategies for the treatment of cytokine imbalances in pregnancy...
  26. ncbi Invasion of the leukocytes into the fetal-maternal interface during pregnancy
    Nardhy Gomez-Lopez
    Department of Obstetrics and Gynecology, Universityof Alberta, Edmonton, Alberta, Canada
    J Leukoc Biol 88:625-33. 2010
    ..In this review, we discuss leukocyte infiltration and recruitment and the potential roles of each subpopulation of leukocytes in relation to pregnancy and the problems of preterm birth, pre-eclampsia, and intrauterine growth restriction...
  27. pmc Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice
    Yuki Takayanagi
    Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai, Miyagi 981 8555, Japan
    Proc Natl Acad Sci U S A 102:16096-101. 2005
    The oxytocin receptor (OXTR) and its ligand, oxytocin (OXT), regulate reproductive physiology (i.e., parturition and lactation) and sociosexual behaviors...
  28. ncbi Dynamics of cervical remodeling during pregnancy and parturition: mechanisms and current concepts
    R Ann Word
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Semin Reprod Med 25:69-79. 2007
    ..biological processes, the phenomenal connective tissue remodeling that occurs in the cervix during and after parturition is unparalleled in scope and magnitude...
  29. ncbi Interleukin-6 is an essential determinant of on-time parturition in the mouse
    Sarah A Robertson
    Robinson Institute, School of Pediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia
    Endocrinology 151:3996-4006. 2010
    ..prostaglandin synthesis and signaling in isolated uterine cells, but whether IL-6 is essential for normal parturition is unknown...
  30. ncbi Human myometrial gene expression before and during parturition
    Jon C Havelock
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Biol Reprod 72:707-19. 2005
    Identification of temporal and spatial changes in myometrial gene expression during parturition may further the understanding of the coordinated regulation of myometrial contractions during parturition...
  31. ncbi A comprehensive immunohistochemistry of prostaglandins F2α and E2 synthetic enzymes in rat ovary and uterus around parturition
    Hironori Satoh
    Laboratory of Veterinary Physiology, Kitasato University School of Veterinary Medicine, Towada, Aomori 034 8628, Japan
    Prostaglandins Other Lipid Mediat 106:23-8. 2013
    ..enzymes was undertaken to identify the cellular types and enzyme isoforms in rat ovary and uterus around parturition. In general ovarian and uterine cells showed positive immunoreactions for phospholipase A2 groups 4A and 6A, ..
  32. ncbi Posttraumatic stress following childbirth: a review
    Eelco Olde
    Department of Clinical Psychology, Utrecht University, Heidelberglaan 1, 3584 CS Utrecht, The Netherlands
    Clin Psychol Rev 26:1-16. 2006
    ..First, traumatic reactions to childbirth are an important public health issue. Secondly, studying childbirth offers opportunity to prospectively study the development of posttraumatic stress reactions...
  33. pmc Maternal circulating levels of activin A, inhibin A, sFlt-1 and endoglin at parturition in normal pregnancy and pre-eclampsia
    Aparna Reddy
    Fetal Medicine Unit, Elizabeth Gareth Anderson Hospital, University College Hospital, London, United Kingdom
    PLoS ONE 4:e4453. 2009
    ..Therefore, the objective of this study is to investigate if these proteins are altered in maternal circulation of labouring pre-eclampsia and normal pregnancies...
  34. ncbi Endocrinology of parturition
    Victoria Snegovskikh
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Endocrinol Metab Clin North Am 35:173-91, viii. 2006
  35. ncbi Real-time ultrasound measure of the fetal eye (vitreous body) for prediction of parturition date in small ponies
    R M Turner
    Section of Reproductive Studies, University of Pennsylvania, School of Veterinary Medicine, New Bolton Center, 382 West Street Road, Kennett Square, 19348, USA
    Theriogenology 66:331-7. 2006
    ..ranges for ultrasonographic measures of fetal eyes in small ponies for the purpose of predicting days before parturition (DBP) when breeding or ovulation dates are unknown...
  36. ncbi Fathers' birth experience in relation to midwifery care
    Ingegerd Hildingsson
    Department of Health Science, Mid Sweden University, Sundsvall, Sweden
    Women Birth 24:129-36. 2011
    ..The aim was to identify the proportion of fathers having a positive experience of a normal birth and to explore factors related to midwifery care that were associated with a positive experience...
  37. ncbi The fetal placental hypothalamic-pituitary-adrenal (HPA) axis, parturition and post natal health
    J R Challis
    Department of Physiology, University of Toronto, 1 King s College Circle, Med Sciences, Building MSB 3205 7, Toronto, Ontario, Canada M5S 1A8
    Mol Cell Endocrinol 185:135-44. 2001
    ..Thus, the level of fetal HPA activity is crucial not only for determining gestation length, but may also predict pathophysiologic adjustments in later life...
  38. ncbi Invoking vali: painful technologies of modern birth in south India
    Cecilia Van Hollen
    Department of Anthropology, University of Notre Dame, USA
    Med Anthropol Q 17:49-77. 2003
    ..Discourses on relationships among gender, pain, and modernity relate to political-economic constraints on hospitals to perpetuate this practice...
  39. ncbi Relationships between season of birth, schizotypy, temperament, character and neurocognition in a non-clinical population
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Psychiatry Res 195:69-75. 2012
    ..These results support the notion that schizotypy and schizophrenia are neurodevelopmental conditions on the same continuum...
  40. ncbi The relationship between prenatal control, expectations, experienced control, and birth satisfaction among primiparous women
    Cynthia D Fair
    Human Services Department, CB 2338, Elon University, Elon, NC 27244, USA
    Midwifery 28:39-44. 2012
    ..This paper explores the relationship between perceptions of prenatal control, expectations for childbirth, and experienced control in labour and birth and how they individually and collectively affect birth satisfaction...
  41. ncbi The birthing experiences of rural Aboriginal women in context: implications for nursing
    Helen Brown
    School of Nursing, University of British Columbia, Vancouver, Canada
    Can J Nurs Res 43:100-17. 2011
    ..The implications for nurses of accounting for the intersecting dynamics that shape Aboriginal women's experiences and birth outcomes are discussed...
  42. ncbi Effects of birth ball exercise on pain and self-efficacy during childbirth: a randomised controlled trial in Taiwan
    Meei Ling Gau
    Graduate Institute of Nurse Midwifery, National Taipei University of Nursing and Health Sciences, Taiwan, ROC
    Midwifery 27:e293-300. 2011
    ..In addition, it tested the mediating effects of childbirth self-efficacy on the relationship between the birth ball exercise programme and childbirth pain...
  43. pmc Molecular mechanisms related to parturition-induced stress urinary incontinence
    Guiting Lin
    Department of Urology, School of Medicine, University of California, San Francisco, CA 94143, USA
    Eur Urol 55:1213-22. 2009
    ..The molecular mechanisms underlying stress urinary incontinence (SUI) at the tissue level are poorly understood...
  44. ncbi Fear of childbirth before, during, and after childbirth
    Siw Alehagen
    Division of Nursing, Department of Medicine and Care, Faculty of Health Sciences, Linkoping University, S 581 85 Linkoping, Sweden
    Acta Obstet Gynecol Scand 85:56-62. 2006
    ..Finally, fear after childbirth (W-DEQ version B) was measured two hours, two days, and five weeks after delivery...
  45. ncbi A qualitative study of women's feelings about future childbirth: dread and delight
    Linda Rilby
    Department of Obstetrics and Gynecology, Sahlgrenska University Hospital Ostra, Sweden
    J Midwifery Womens Health 57:120-5. 2012
    ..The purpose of this study is thus to describe the emotions of this group concerning future childbirth...
  46. ncbi Accuracy of canine parturition date prediction using fetal measurements obtained by ultrasonography
    Michelle A Kutzler
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Theriogenology 60:1309-17. 2003
    ..Early and accurate determination of canine gestational age is useful for predicting and managing parturition. We performed a retrospective study on fetal measurements obtained by transabdominal ultrasonographic ..
  47. ncbi What characterizes women in Norway who wish to have a caesarean section?
    Tone Kringeland
    Stord Haugesund University College, Norway
    Scand J Public Health 37:364-71. 2009
    ..The aim of this study was to describe the characteristics of pregnant women who wish to have a caesarean section...
  48. ncbi "It's all the rage these days": University students' attitudes toward vaginal and cesarean birth
    Kathrin Stoll
    Division of Midwifery, Department of Family Practice, University of British Columbia, B54 2194 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada
    Birth 36:133-40. 2009
    ....
  49. ncbi Pineal gland (melatonin) affects the parturition time, but not luteal function and fetal growth, in pregnant rats
    Hisako Takayama
    Reproductive, Pediatric and Infectious Science, Perinatal Care Center, Yamaguchi University School of Medicine, 1 1 1, Minami Kogushi, Ube 755 8505 Japan
    Endocr J 50:37-43. 2003
    The purpose of the present study was to investigate the role of pineal gland (melatonin) on parturition time, luteal function, and fetal growth in pregnant rats...
  50. ncbi Loss of hepatitis C virus RNA after parturition in female patients with chronic HCV infection
    Yuko Hattori
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Med Virol 71:205-11. 2003
    ..The aim of this study was to investigate the relationship between pregnancy and parturition with HCV viremia levels and the natural resolution of HCV RNA...
  51. ncbi A comparative study of expectant parents ' childbirth expectations
    Bi Chin Kao
    National Taichung Nursing College, ROC
    J Nurs Res 12:191-202. 2004
    ....
  52. ncbi Men's passage to fatherhood: an analysis of the contemporary relevance of transition theory
    Jan Draper
    Royal College of Nursing Institute, Distance Learning Unit, London, UK
    Nurs Inq 10:66-77. 2003
    ....
  53. ncbi Calcineurin/NFAT pathway: a novel regulator of parturition
    Chisa Tabata
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka 5650871, Japan
    Am J Reprod Immunol 62:44-50. 2009
    The oxytocin (OT)-oxytocin receptor (OTR) system plays an important role in mammalian parturition. However, we found OTR-deficient (OTRKO) mice are fertile and deliver at term without birth defects, thus alternative pathways inducing ..
  54. pmc Human uterine wall tension trajectories and the onset of parturition
    Peter Sokolowski
    Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, John Hunter Hospital, Newcastle, Australia
    PLoS ONE 5:e11037. 2010
    ..We characterize human uterine wall tension using ultrasound from the second trimester of pregnancy until parturition and compare preterm, term and twin pregnancies...
  55. ncbi Behind the myth--few women prefer caesarean section in the absence of medical or obstetrical factors
    Annika Karlström
    Mid Sweden Research and Development Centre, Vasternorrland County Council, Sundsvall SE 851 86, Sweden
    Midwifery 27:620-7. 2011
    ..to describe the prevalence of women's preference for caesarean section as expressed in mid pregnancy, late pregnancy and one year post partum. An additional aim was to identify associated factors and investigate reasons for the preference...
  56. ncbi Fathers in the birth room: what are they expecting and experiencing? A phenomenological study
    Heather L Longworth
    Midwifery Research Department, Room 54, Antenatal Clinic, Liverpool Women s Hospital NHS Foundation Trust, Crown Street, Liverpool L8 7SS, UK
    Midwifery 27:588-94. 2011
    ..to explore the role, expectations and meanings that individual fathers ascribe to their presence at birth...
  57. pmc Pain acceptance and personal control in pain relief in two maternity care models: a cross-national comparison of Belgium and the Netherlands
    Wendy Christiaens
    Department of Sociology, Ghent University, Ghent, Belgium
    BMC Health Serv Res 10:268. 2010
    ..In the Netherlands the midwifery model of care defines childbirth as a normal physiological process and family event. Labour pain is perceived as an ally in the birth process...
  58. ncbi Induction of parturition in dairy cattle and its effects on health and subsequent lactation and reproductive performance
    P D Mansell
    University of Melbourne, Rural Veterinary Unit, 10 Johnson Street, Maffra VIC 3860, Australia
    Aust Vet J 84:312-6. 2006
    To determine the effect of induction of parturition on health, milk production and reproductive performance of dairy cows.
  59. pmc Malaria at parturition in Nigeria: current status and delivery outcome
    Olugbenga A Mokuolu
    Department of Pediatrics, University of Ilorin Teaching Hospital, Ilorin 240001, Nigeria
    Infect Dis Obstet Gynecol 2009:473971. 2009
    To evaluate the current status of malaria at parturition and its impact on delivery outcome in Nigeria.
  60. ncbi Progesterone receptors, oestrogen receptor alpha and glucocorticoid receptors in the bovine intercaruncular uterine wall around parturition
    M Schäubli
    Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
    Anim Reprod Sci 103:215-27. 2008
    ..This is in strict contrast to the placentome. Comparatively lower local tissue estrogen concentrations around term may be one cause for this difference...
  61. ncbi The role of oxytocin in parturition
    Andrew M Blanks
    Walsgrave Hospital, Clifford Bridge Road, Coventry, UK
    BJOG 110:46-51. 2003
    ....
  62. ncbi Dynamic changes in oxytocin receptor expression and activation at parturition in the rat brain
    Simone L Meddle
    Centre for Integrative Physiology, College of Medicine and Veterinary Medicine, University of Edinburgh, George Square, Edinburgh, United Kingdom
    Endocrinology 148:5095-104. 2007
    Oxytocin plays a pivotal role in rat parturition, acting within the brain to facilitate its own release in the supraoptic nucleus (SON) and paraventricular nucleus, and to stimulate maternal behavior...
  63. ncbi Onset of lactation in the bovine mammary gland: gene expression profiling indicates a strong inhibition of gene expression in cell proliferation
    Kiera A Finucane
    Lactation and Mammary Gland Biology Group, Department of Animal Science, University of Vermont, Burlington, VT 05405, USA
    Funct Integr Genomics 8:251-64. 2008
    ..expression profiles of approximately 23,000 gene transcripts in bovine mammary tissue about day 5 before parturition and day 10 after parturition...
  64. ncbi Women's experiences after a third-degree obstetric anal sphincter tear: a qualitative study
    Abimbola Williams
    Urodynamics Department, Liverpool Women s Hospital, Liverpool, United Kingdom
    Birth 32:129-36. 2005
    ..The objective of this study was to explore the views and experiences of women in the postpartum period after sustaining a third-degree obstetric anal sphincter tear...
  65. pmc Estrogen and progesterone metabolism in the cervix during pregnancy and parturition
    Stefan Andersson
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9032, USA
    J Clin Endocrinol Metab 93:2366-74. 2008
    ..nonprimate species demonstrate that progesterone withdrawal leads to changes in gene expression that initiate parturition at term...
  66. ncbi Pre- and postpartum levels of childbirth fear and the relationship to birth outcomes in a cohort of Australian women
    Jennifer Fenwick
    School of Nursing and Midwifery, Curtin University of Technology, Perth, WA, Australia
    J Clin Nurs 18:667-77. 2009
    ..To investigate pre- and postpartum levels of childbirth fear in a cohort of childbearing women and explore the relationship to birth outcomes...
  67. ncbi Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase
    Roland P Piekorz
    Howard Hughes Medical Institute, Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Endocrinol 19:431-40. 2005
    ..20alpha-HSD) and a decrease in serum progesterone, which normally declines only immediately before parturition. To determine the relative contribution of 20alpha-HSD to progesterone metabolism and Stat5 function during ..
  68. ncbi The onset of human parturition
    Remah Moustafa Kamel
    Department of Obstetrics and Gynaecology, Faculty of Medicine, Jazan University, Jazan, Saudi Arabia
    Arch Gynecol Obstet 281:975-82. 2010
    ..Despite impressive progress in the science and technology of reproduction, the mechanism by which labour is initiated in humans remains obscure...
  69. ncbi Therapeutic group psychoeducation and relaxation in treating fear of childbirth
    Terhi Saisto
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Jorvi Hospital, Espoo, Finland
    Acta Obstet Gynecol Scand 85:1315-9. 2006
    ..The increase in the numbers of women fearing childbirth and requesting cesarean sections call for new forms of antenatal treatment...
  70. ncbi Managing the dairy cow at calving time
    John F Mee
    Dairy Production Department, Teagasc, Dairy Production Research Centre, Moorepark, Fermoy, Co Cork, Ireland
    Vet Clin North Am Food Anim Pract 20:521-46. 2004
    ....
  71. ncbi The importance of fibroblasts in remodelling of the human uterine cervix during pregnancy and parturition
    Erik Malmström
    Department of Experimental Medical Science, BMC, Lund University, Lund, Sweden
    Mol Hum Reprod 13:333-41. 2007
    ..Our data suggest that remodelling of the human cervix is orchestrated by fibroblasts, which are activated or recruited by the inflammatory processes occurring during the ripening cascade...
  72. ncbi The preterm parturition syndrome
    R Romero
    Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
    BJOG 113:17-42. 2006
    ..paradigm that has governed the study and clinical management of preterm labour is that term and preterm parturition are the same processes, except for the gestational age at which they occur...
  73. ncbi Prokineticins: novel mediators of inflammatory and contractile pathways at parturition?
    Rob D Catalano
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    Mol Hum Reprod 16:311-9. 2010
    ..Antagonism of prokineticin action may provide a suitable therapy for preterm labour that targets both inflammation and contractile pathways...
  74. pmc Expression of the calcium-activated potassium channel in upper and lower segment human myometrium during pregnancy and parturition
    Lu Gao
    Department of Physiology, Second Military Medical University, Shanghai 200433, PR China
    Reprod Biol Endocrinol 7:27. 2009
    ....
  75. pmc Assessment of social psychological determinants of satisfaction with childbirth in a cross-national perspective
    Wendy Christiaens
    Department of Sociology, Ghent University, Ghent, Belgium
    BMC Pregnancy Childbirth 7:26. 2007
    ..In this paper we examine multiple determinants, the fulfilment of expectations, labour pain, personal control and self-efficacy, for their association with satisfaction with childbirth in a cross-national perspective...
  76. ncbi Progesterone withdrawal: key to parturition
    Tamas Zakar
    Division of Obstetrics and Gynaecology, John Hunter Hospital, University of Newcastle, Newcastle, NSW, Australia
    Am J Obstet Gynecol 196:289-96. 2007
    ..laboratory rodents, and discuss some of the more recent ideas about "functional progesterone withdrawal," in an attempt to bridge the apparent differences between the regulation of parturition in human and subprimate mammals.
  77. ncbi Neuroendocrine mechanisms in pregnancy and parturition
    Felice Petraglia
    University of Siena, Policlinico, Division of Obstetrics and Gynecology, Department of Pediatrics, Obstetrics, and Reproductive Medicine, Viale Bracci, 53100 Siena, Italy
    Endocr Rev 31:783-816. 2010
    The complex mechanisms controlling human parturition involves mother, fetus, and placenta, and stress is a key element activating a series of physiological adaptive responses...
  78. ncbi Obstetric outcome for women who received individualized treatment for fear of childbirth during pregnancy
    Gunilla Sydsjo
    Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Department of Obstetrics and Gynecology in Linköping, County Council of Ostergotland, Linkoping, Sweden
    Acta Obstet Gynecol Scand 91:44-9. 2012
    ..To compare obstetric outcomes for women with fear of childbirth who received counseling during pregnancy with women without fear of childbirth. ..
  79. pmc The meaning of "control" for childbearing women in the US
    Emily E Namey
    Duke University, Department of Obstetrics and Gynecology, Trent Center for Bioethics, Humanities and History of Medicine, 108 Seeley G Mudd, Durham, NC 27710, USA
    Soc Sci Med 71:769-76. 2010
    ..Together, these findings call into question the usefulness of the term for measuring quality or improving maternity care and highlight other concepts which may be more fruitfully explored...
  80. pmc Amniotic fluid sTREM-1 in normal pregnancy, spontaneous parturition at term and preterm, and intra-amniotic infection/inflammation
    Juan Pedro Kusanovic
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 23:34-47. 2010
    ..The aim of this study was to determine the effect of gestational age, parturition (term and preterm) and IAI in the amniotic fluid (AF) concentrations of sTREM-1.
  81. ncbi Thoughts and emotions during traumatic birth: a qualitative study
    Susan Ayers
    Psychology Department, University of Sussex, Brighton, Sussex, United Kingdom
    Birth 34:253-63. 2007
    ..The objective of this study was to examine thoughts and emotions during birth, cognitive processing after birth, and memories of birth that might be important in the development of postnatal posttraumatic stress symptoms...
  82. ncbi Sex ratio at birth, polygyny, and fertility: a cross-national study
    Nigel Barber
    Soc Biol 51:71-7. 2004
    ..The sex ratio evidently declines with increases in fertility because more children are born at a later birth order when frequency of intercourse is lower...
  83. ncbi The attitudes of Canadian maternity care practitioners towards labour and birth: many differences but important similarities
    Michael C Klein
    Developmental Neuroscience and Child Health, Child and Family Research Institute, University of British Columbia, Vancouver BC
    J Obstet Gynaecol Can 31:827-40. 2009
    ..Differing attitudes of maternity care providers may impede this process. We sought to examine the attitudes of Canadian maternity care practitioners towards labour and birth...
  84. pmc Region-specific gene expression profiling: novel evidence for biological heterogeneity of the human amnion
    Yu Mi Han
    Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Reprod 79:954-61. 2008
    The amnion plays an important role during pregnancy and parturition. Though referred to as a single structure, this fetal tissue is regionally divided into placental amnion, reflected amnion, and umbilical amnion...
  85. ncbi Improving calving management to further enhance reproductive performance in dairy cattle
    M Paolucci
    Department of Pathology, Diagnostic and Veterinary Clinics, University of Perugia, Perugia, Italy
    Vet Res Commun 34:S37-40. 2010
    ..Based on the results of this study, we advocate the use of GSM technology on large farms for intensive milk production...
  86. pmc Plasma membrane receptor mediated MAPK signaling pathways are activated in human uterine cervix at parturition
    Hong Wang
    Division for Reproductive Endocrinology, Karolinska University Hospital and Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Reprod Biol Endocrinol 5:3. 2007
    ..The aim of this study was to investigate whether plasma membrane receptor mediated pathways, known to be activated by estrogens and proinflammatory compounds, are involved in cervical ripening before labor...
  87. pmc Parturition date for a given female is highly repeatable within five roe deer populations
    Floriane Plard
    Laboratoire de Biometrie et Biologie Evolutive, Universite de Lyon, 69000, Lyon, France
    Biol Lett 9:20120841. 2013
    ..a given female is also repeatable within populations of birds, limited evidence suggests low repeatability of parturition date for individual females in mammals, and between-population variability in repeatability has never, to our ..
  88. ncbi Changes in concentrations of follistatin in maternal plasma and foetal fluids during pregnancy and parturition in sheep
    Yin Xia
    Centre for Bioactive Discovery in Health and Aging, University of New England, Armidale NSW 2351, Australia
    Anim Reprod Sci 114:148-56. 2009
    Studies have shown that follistatin may be involved in the regulation of ovarian development, pregnancy and parturition. The aim of the present study was to measure follistatin levels in maternal plasma and foetal fluids during pregnancy ..
  89. ncbi A metasynthesis of midwife-led care
    Denis Walsh
    University of Nottingham, Nottingham, UK
    Qual Health Res 22:897-910. 2012
    ....
  90. ncbi The role of glucocorticoids in pregnancy, parturition, lactation, and nurturing in melanocortin receptor 2-deficient mice
    Dai Chida
    Department of Immunology and Pathology, Research Institute, National Center for Global Health and Medicine, 1 21 1, Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Endocrinology 152:1652-60. 2011
    ..Here we analyzed the role of glucocorticoids in pregnancy, parturition, lactation, and nurturing in MC2R(-/-) mice...
  91. ncbi Relationships between colostrum production by primiparous sows and sow physiology around parturition
    A Foisnet
    INRA, UMR1079 Systèmes d Elevage Nutrition Animale et Humaine, F 35590 Saint Gilles, France
    J Anim Sci 88:1672-83. 2010
    Relationships between hormonal and metabolic changes around parturition and colostrum yield and composition were investigated in 16 Landrace x Large White primiparous sows...
  92. ncbi Dynamic changes of immunoglobulin concentrations in pig colostrum and serum around parturition
    I Markowska-Daniel
    Department of Swine Diseases, National Veterinary Research Institute, al Partyzantow 57, 24 100 Puławy, Poland
    Pol J Vet Sci 13:21-7. 2010
    ..The mean IgA, IgM and IgG concentrations in sow serum 10 days before parturition were 1.58, 6.12 and 39.56 mg/ml, respectively...
  93. ncbi The human fetal adrenal gland, corticotropin-releasing hormone, and parturition
    Victor E Beshay
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Semin Reprod Med 25:14-20. 2007
    ..of active research involves the study of the different mechanisms that may lead to successful signaling for parturition. This review focuses on the fetal-derived signals that lead to the initiation of labor...
  94. pmc Evidence of the involvement of caspase-1 under physiologic and pathologic cellular stress during human pregnancy: a link between the inflammasome and parturition
    Francesca Gotsch
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 21:605-16. 2008
    ..The objectives of this study were to determine whether there is a relationship between amniotic fluid concentrations of caspase-1 and gestational age, parturition (term and preterm), and intra-amniotic infection/inflammation (IAI).
  95. ncbi Comparison of the accuracy of two ultrasonographic measurements in predicting the parturition date in the bitch
    M Beccaglia
    Department of Veterinary Clinical Sciences Obstetrics and Gynaecology, University of Milan, Via Celoria 10, 20133 Milan, Italy
    J Small Anim Pract 47:670-3. 2006
    ..ultrasonographic measurements, inner chorionic cavity diameter and biparietal diameter, for the prediction of parturition date in small and medium size bitches...
  96. ncbi The early origins of asthma: nature, nurture, or parturition?
    Jonathan E Spahr
    Ann Allergy Asthma Immunol 94:211-2. 2005
  97. ncbi Post-traumatic stress symptoms, parenting stress and mother-child relationships following childbirth and at 2 years postpartum
    Sarah McDonald
    Nottinghamshire NHS, Adult Mental Health, Kirkby in Ashfield, Mansfield, Nottingham, UK
    J Psychosom Obstet Gynaecol 32:141-6. 2011
    ..Implications for clinical practice and the concept of childbirth-related post-traumatic stress disorder are discussed...
  98. ncbi Molecular pathways regulating contractility in rat uterus through late gestation and parturition
    Michael J Taggart
    Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom
    Am J Obstet Gynecol 207:76.e15-24. 2012
    ..Our objective was to assess expression of key constituents of these pathways, in alliance with contractile function, through late gestation and during term and preterm labor...
  99. ncbi Risk factors in pregnancy for post-traumatic stress and depression after childbirth
    J Soderquist
    Department of Welfare and Social Studies ISV, Linkoping University, Campus Norrköping, Norrkoping, Sweden
    BJOG 116:672-80. 2009
    ..The objective of this study was to find risk factors in pregnancy for post-traumatic stress and depression 1 month after childbirth. Furthermore, the relation between post-traumatic stress and depression was explored...
  100. ncbi Ethnic Turkish fathers in birth support roles in a Berlin labour and delivery room--motives, preparation and incidence in a 10-year comparison
    Matthias David
    Charite, Universitatsmedizin Berlin, Campus Virchow Klinikum, Klinik fur Frauenheilkunde und Geburtshilfe, Berlin, Germany
    J Psychosom Obstet Gynaecol 30:5-10. 2009
    ..Turkish (T) fathers with respect to birth preparation or motivation to participate in a birth support role? In a 10-year comparison is it possible to identify an increase among ethnic Turkish fathers in birth support roles in Germany?..
  101. pmc Concurrent analysis of choice and control in childbirth
    Austyn Snowden
    School of Health, Nursing and Midwifery, University of the West of Scotland, Paisley Campus, Paisley, PA1 2BE, Scotland, UK
    BMC Pregnancy Childbirth 11:40. 2011
    ..This paper reports original research on choice and control in childbirth. Eight women were interviewed as part of a wider investigation into locus of control in women with pre-labour rupture of membranes at term (PROM)...

Research Grants65

  1. NEURAL AND ENDOCRINE CONSEQUENCES OF PARITY
    ROBERT STAFFORD BRIDGES; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Reproductive experience (i.e. pregnancy, parturition and lactation) results in long lasting alterations in the female mammal's neural and endocrine systems...
  2. Epithelial Sodium Channels in the Supraoptic Vasopressin and Oxytocin Neurons
    Ryoichi Teruyama; Fiscal Year: 2009
    ..In addition to the well known effects of OT during parturition and lactation, plasma OT increases in response to hypernatremia (Huang et al...
  3. Role of Physico-chemical Properties in the Reprotoxicity of Inhaled Cd NP.
    JUDITH TERRY ZELIKOFF; Fiscal Year: 2010
    ..effects on the release and actions of select hormones/cytokines important for pregnancy maintenance and parturition. Timed-pregnant mice exposed to relevant levels of either nanosize (i.e., fresh) or agglomerated (i.e...
  4. Genetics of Spontaneous Pelvic Organ Prolapse in the Mouse
    Jay E Reeder; Fiscal Year: 2010
    ..an autosomal dominant trait, is seen in both males and females and no precipitating event (such as pregnancy or parturition) is necessary...
  5. Genomic actions of progesterone receptors in human myometrial cells
    Sam Mesiano; Fiscal Year: 2010
    ..that in human pregnancy progesterone promotes myometrial quiescence via nPR-mediated genomic pathways and that parturition involves functional withdrawal of nPR-mediated progesterone actions, which allows the pro-contraction pathways ..
  6. Preeclampsia, IUGR and Hypertension: Targets for Treatment
    Joey P Granger; Fiscal Year: 2013
    ..S. Hypertension associated with PE develops during pregnancy and remits after parturition implicating the placenta as a central culprit in the disease...
  7. INITIATION OF HUMAN LABOR: PREVENTION OF PREMATURITY
    Carole R Mendelson; Fiscal Year: 2013
    ..this proposal remains the elucidation of the molecular and cellular mechanisms that lead to the initiation of parturition, both at term and preterm...
  8. Mechanisms of 5'UTR splicing of human surfactant protein (SP)-A1 and SP-A2
    Guirong Wang; Fiscal Year: 2011
    ..host defense and the inflammatory regulation of lung, in surfactant-related physiological functions, and in parturition. In humans, there are two functional genes, SP-A1 and SP-A2...
  9. Role of nuclear progesterone receptors in the control of human parturition
    Sam Mesiano; Fiscal Year: 2013
    ..Another important concept to arise from our research is that the parturition-associated increase in myometrial cell PR-A expression, which is a key event in human parturition, is up-..
  10. Obesity and deregulation of imprinted genes in early life
    Susan Kay Murphy; Fiscal Year: 2013
    ..We will combine NEST periconceptional, prenatal, parturition and age one year data with data proposed for collection at ages 3 and 5 years to evaluate these exposures in ..
  11. FUNCTIONAL DEVELOPMENT OF THE MAMMARY GLAND
    Steven M Anderson; Fiscal Year: 2013
    ..prolactin, secretory differentiation occurring during late pregnancy, and secretory activation that occurs at parturition. A failure at any stage often results in ineffective lactation, indicated by either inadequate growth or death ..
  12. NEURAL REGULATION OF PREPARTUM CERVICAL RIPENING
    Steven M Yellon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Complications related to the process of parturition represent the most significant challenges to the field of Obstetrics, Maternal-Fetal Medicine, as well as for Neonatology, and Pediatrics...
  13. Pittsburgh Pelvic Floor Research Program
    Halina M Zyczynski; Fiscal Year: 2013
    ..to large numbers of nulliparous women enables us to contribute uniquely to studies of the role of pregnancy and parturition in the etiology and prevention of pelvic floor disorders (PFDs)...
  14. Admixture Mapping of Preterm Birth Genes
    Jerome F Strauss; Fiscal Year: 2013
    ..Finally, genetic markers could refine understanding of the normal as well as pathologic processes underlying parturition, and lead to innovative medical treatments based on contributing genes...
  15. Architectural Design of the Pelvic Floor Skeletal Muscles
    Marianna Alperin; Fiscal Year: 2013
    ..provide support to the pelvic viscera and aid in continence, as well as facilitate urination, defecation, and parturition. We hypothesize that individual pelvic floor muscles'architecture and ECM are differentiated to allow for ..
  16. OVERALL - GENE-ENVIRONMENT INTERACTIONS IN HUMAN PARTURITION
    Pathik Wadhwa; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): This Program Project, entitled Gene-Environment Interactions in Human Parturition, proposes to evaluate the utility of information about DMA sequence variation and function in candidate ..
  17. Diversity &racial disparity in fetal membrane cytokine signature during infectio
    Ramkumar Menon; Fiscal Year: 2012
    ..a series of events that compromise the immunological privileges that the fetus enjoys from conception until parturition by stimulating the production proinflammatory cytokines and chemokines that induce labor;however, the immune ..
  18. ANIMAL MODELS FOR STUDYING THE GENETICS OF HYPERTENSION
    Oliver Smithies; Fiscal Year: 2013
    ..of suggesting new interventions which may be able to postpone or avoid both the need for inducing early parturition in women with severe pre-eclampsia, and the need to discontinue the use of VEGF inhibitors in cancer patients ..
  19. Role of GRK6-Mediated Oxytocin Receptor Desensitization in Labor
    Chad A Grotegut; Fiscal Year: 2013
    ..goal is to improve the lives of women and their families by conducting innovative, patient-relevant research in parturition to improve pregnancy and labor outcomes...
  20. Maternal temperament, stress, and inflammation in preterm birth
    LOUIS JOSEPH MUGLIA; Fiscal Year: 2013
    ..Our long-term goal is to determine the mechanisms that disrupt the normal timing for parturition and lead to preterm birth...
  21. Renal Transporters and Fetal Neuroendocrinology
    Charles E Wood; Fiscal Year: 2013
    ..be key to understanding fetal stress, homeostasis, and (in sheep and perhaps in other species) the control of parturition. In past years, we have investigated several of the physiological and endocrine mechanisms controlling the ..
  22. Drug Abuse Vulnerability: Role of Development and Gender
    Lisa M Schrott; Fiscal Year: 2010
    ..that are made dependent on a long-acting synthetic opiate one month prior to breeding, with treatment through parturition. After birth the pups will be fostered to drug-naive mothers and undergo opiate withdrawal...
  23. Reproductive Plasticity in Oxytocin Neurons
    William E Armstrong; Fiscal Year: 2013
    ..made by OT neurons, and how it shapes OT neuronal firing to maximize hormone release and thereby insure normal parturition and lactation for infant development...
  24. Genome-wide association studies of prematurity and its complications
    Jeffrey C Murray; Fiscal Year: 2010
    ..The study should enable a better understanding of the biology of parturition, identify common genetic factors that play a role in prematurity and suggest environmental modifications that ..
  25. Defining Gene Expression Programs in Cervical Ripening: Roles for Non-Coding RNAs
    Mala S Mahendroo; Fiscal Year: 2013
    ..in this study will suppor the future potential of these approaches to dissect the molecular pathways that regulate processes critical for successful parturition at term and to understand how regulatory circuits go awry in preterm birth.
  26. Molecular Mechanisms of Parturition
    Mala S Mahendroo; Fiscal Year: 2010
    b>Parturition, the process of giving birth, is an essential biological function for which the molecular mechanisms are poorly understood...
  27. Premature Uterine Ageing and Preterm Delivery
    Jeeyeon Cha; Fiscal Year: 2013
    ..without luteolysis are powerful tools for studying the underlying mechanism as they more closely mimic human parturition. A new mouse model of preterm delivery using uterine-specific deletion of the Trp53 gene encoding p53 has been ..
  28. Toll-like receptor signaling in the pathogenesis and prevention of prematurity
    Emmet Hirsch; Fiscal Year: 2012
    ..The incidence of preterm delivery continues to rise in the U.S., a fact that reflects continuing deficiencies in our knowledge of the causes and mechanisms of parturition.
  29. REGULATION OF UTERINE SMOOTH MUSCLE EXCITABILITY
    Sarah K England; Fiscal Year: 2010
    ..quiescence during pregnancy requires suppression of myometrial smooth muscle cell (MSMC) excitability until parturition. The large conductance Ca2+-activated K+ channel (maxi-K) contributes to this suppression by mediating a potent ..
  30. Morphogenesis of the chorio-allantoic placenta II: The Allantoic Core Domain
    Karen M Downs; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Instrumental to fetal-maternal exchange during parturition is a correctly formed and functioning chorio-allantoic placenta...
  31. MOLECULAR AND BIOCHEMICAL STUDY OF COLLAGEN IN PROLAPSE
    Anthony Visco; Fiscal Year: 2002
    ..Many researchers have hypothesized that a parturition-related denervation injury to the female pelvic floor leads to weakness of the levator ani muscles which in ..
  32. Positional cloning of mutations that disrupt hair development in mice.
    Thomas R King; Fiscal Year: 2011
    ..Also, the late development of a hairy coat (largely after parturition) and its location on the outside of the body allow easy access to developing mutant and wild type tissues...
  33. Regulation and Function of Internal Ca2+ Stores in Nerve Terminals
    John V Walsh; Fiscal Year: 2010
    ..or Arginine Vasopressin, which have well documented physiological actions on waterbalance, blood pressure, parturition and perhaps even mood...
  34. PREGNANCY & HORMONE EFFECTS ON KIDNEY & URINARY TRACT
    Linda Shortliffe; Fiscal Year: 1999
    ..pelvic and bladder pressures with varying urinary flow rates and bladder volumes in pregnant, nonpregnant, post-parturition, and estrogen and progesterone treated rats...
  35. Progesterone for Postpartum Cocaine Relapse
    Kimberly A Yonkers; Fiscal Year: 2011
    ..preliminary data on whether treatment with progesterone, which would counterbalance the progesterone lost with parturition, reduces cocaine use among postpartum women...
  36. Endocrine Status of MG Stroma Alters Breast CA Invasion
    Pepper Schedin; Fiscal Year: 2004
    ..During parturition or weaning-induced mammary gland involution, mammary stroma is degraded and stroma levels of matrix ..
  37. PLATELET ACTIVATING FACTOR DEPENDENT TRANSACETYLASES
    TEN CHING LEE; Fiscal Year: 1999
    ..bronchoconstriction, systemic hypotension, inflammatory and allergic reactions, implantation and parturition. Some of these biological effects are shown to be mediated through surface or intracellular receptor(s)...
  38. ARACHIDONATE LIPOXYGENASE ACTIVITIES IN HUMAN PREGNANCY
    Murray Mitchell; Fiscal Year: 1992
    ..health and intellectual development of an individual is often determined substantially during pregnancy and parturition. Lack of normal physiological adaptations with pregnancy, specific diseases of pregnancy e.g...
  39. The Molecular Pathogenesis of Health Disparities in Inf*
    Emmet Hirsch; Fiscal Year: 2005
    ..of preterm labor requires the power to perform analyses of the fetomaternal interactions required for parturition on a genomic scale...
  40. Female Reproductive Organs and Their Innervation.
    RAYMOND PAPKA; Fiscal Year: 2006
    ..mechanisms for integration of uterine cervical information and how these play a role in cervical ripening and parturition (act of giving birth) - particularly as this relates to pre-term or protracted labor, spinal cord-injured ..
  41. Spike After-Potentials of Oxytocin Cells in Lactation
    Ryoichi Teruyama; Fiscal Year: 2005
    ..of the hypothalamus is one of the best models to study such adaptation, because the importance of OT during parturition and lactation are well documented...
  42. OXYTOCIN REGULATION BY NEUROSTEROIDS & GABA-A RECEPTOR
    Janet Amico; Fiscal Year: 2003
    ..OT is essential for milk ejection during lactation, enhances uterine contractility at parturition and induces maternal behavior in the rat...
  43. SIGNAL TRANSDUCTION MECHANISMS AND AMNION PGE2 SYNTHESIS
    Leslie Myatt; Fiscal Year: 1993
    ..and release of eicosanoids by amnion in response to a fetal or maternal signal may be involved the onset of parturition in humans but the intracellular signal transduction mechanisms that lead to eicosanoid synthesis (the response) ..
  44. MYOMETRIAL GAP JUNCTION MODULATION IN PRETERM LABOR
    WILLIAM LARSEN; Fiscal Year: 1990
    ..dramatic development of a functional population of myometrial gap junctions in the final 24-72 hours prior to parturition. Shortly after parturition, this population of gap junctions disappears...
  45. PARTURITION INDUCED PELVIC FLOOR NEUROPATHY
    KARL THOR; Fiscal Year: 2003
    ..Recently, we established the squirrel monkey as a model of parturition-associated prolapse...
  46. REPRODUCTIVE EFFECTS OF OXYTOCIN DEFICIENCY
    CHRISTINA LUEDKE; Fiscal Year: 2001
    ..oxytocin-deficient mouse to reproduce will be examined in detail, including evaluation of libido, fertility, parturition, breast-feeding, and maternal behavior, in all of which oxytocin has been implicated to play a major role...
  47. ROLE OF ADENYL PURINES IN MYOMETRIAL FUNCTION
    IAIN BUXTON; Fiscal Year: 1993
    ..that adenyl purines, compounds known to cause contraction of uterus, participate in the regulation of human parturition. The specific aims of this research are to discover the origins, binding sites and molecular signaling events ..
  48. EFFECT OF LACTATION ON BONE
    MaryFran Sowers; Fiscal Year: 1993
    ..Radial and femoral bone mass will be measured by single and dual photon absorptiometry, respectively, at parturition, and following parturition at 2 months, 4 months, 6 months, and 12 months...
  49. GENETIC ANALYSIS OF MYOMETRIAL FUNCTION IN PARTURITION
    Kathleen Bethin; Fiscal Year: 2004
    ..In order to study factors that effect parturition, we will develop a system that allows manipulation of uterine myometrial genes in the mouse...
  50. Reproductive Risk Factors for Pelvic Organ Prolapse
    Jeanette Brown; Fiscal Year: 2004
    ..a risk factor for pelvic organ prolapse, there has been limited research on the relationship between specific parturition events and the occurrence of pelvic organ prolapse in later life...
  51. GLUCOCORTICOIDS AND MATRIX PROTEINS AT PARTURITION
    Seth Guller; Fiscal Year: 1999
    The hypothesis of the current proposal is that near parturition, glucocorticoids (GCs) reduce uterine-placental adherence by suppressing the synthesis of fibronectin (FN) and other extracellular matrix (ECM) proteins of cells in placenta ..
  52. Neurochemical control of maternal behavior
    JOSEPH LONSTEIN; Fiscal Year: 2002
    ..It is probable that the hormones of gestation and parturition, as well as sensory cues from pups that dams receive after parturition, influence neurochemical release in the ..
  53. IMMUNIZATION AGAINST ACTH AND PARTURITION
    Dean Myers; Fiscal Year: 2001
    ..as the source of androgen precursor for estrogen formation, the role of the primate fetus in the process of parturition remains unresolved...
  54. FETAL RESPONSES TO SULFOCONJUGATED ESTROGENS
    Charles Wood; Fiscal Year: 2001
    ..be key to understanding fetal stress, homeostasis, and (in sheep and perhaps in other species) the control of parturition. In past years, we have investigated several of the physiological and endocrine mechanisms controlling the ..
  55. Allosteric Potentiators of the Oxytocin System for the Control of Social Motivati
    Michael Jarstfer; Fiscal Year: 2009
    ..Recently, the neuropetide oxytocin, which has well established roles in parturition and lactation, has been implemented in a wide range of complex social behaviors...
  56. FETAL CIRCULATORY RESPONSE TO CEREBRAL COMPRESSION
    Raymond Koehler; Fiscal Year: 1991
    Considerable forces are exerted on the fetal head as it dilates the cervix and pelvic structures during parturition. Because of the compliant fetal skull, these forces can cause intracranial pressure (ICP) to greatly exceed amniotic ..
  57. NEUROCHEMICAL SPINAL CIRCUITRY AND UTERINE INNERVATION
    RAYMOND PAPKA; Fiscal Year: 2000
    ..and how these mechanisms relate to the altered physical and steroid hormone environment of pregnancy and parturition and the changing steroid hormone environment of the estrous cycle...
  58. PROSTAGLANDIN SIGNALING IN FEMALE REPRODUCTION
    John Reese; Fiscal Year: 2005
    ..COX)-derived PGs are implicated in many aspects of reproduction, including ovulation, implantation and parturition, yet limited information is available regarding the regulation of PG ligand-receptor signaling in the uterus...
  59. THE STRUCTURAL BASIS OF RELAXIN ACTION
    Christian Schwabe; Fiscal Year: 1990
    ..hormone that is responsible for those tissue modifications that result in birth canal widening just prior to parturition. Relaxin is produced in the corpus luteum of pregnancy or in the placenta and is a disulfide homolog of insulin ..
  60. ARACHIDONIC ACID METABOLISM AND OVINE PARTURITION
    Murray Mitchell; Fiscal Year: 1990
    ..signal importance in the control of uteroplacental blood flow and in the biochemical mechanisms that result in parturition. Arachidonic acid is metabolized also by way of lipoxygenase enzyme pathways into leukotrienes and related ..
  61. REGULATION OF PROSTAGLANDIN RECEPTORS IN MYOMETRIUM
    Leslie Myatt; Fiscal Year: 1999
    Prostaglandins (PG s) appear to have a major role in the initiation and/or maintenance of parturition. Inhibition of prostaglandin synthesis is used as a mechanism of tocolysis in preterm labor, though not without potentially deleterious ..
  62. NUTRITION, OBESITY AND GESTATIONAL DIABETES IN RATS
    K L Jen; Fiscal Year: 1992
    ..diabetes (GDM), defined as glucose intolerance first developing during gestation and disappearing after parturition, has been diagnosed in 1 to 3% of all human pregnancies...
  63. REGULATION OF PROSTAGLANDIN BIOSYNTHESIS IN PARTURITION
    EDWARD DENNIS; Fiscal Year: 1999
    ..metabolites including prostaglandins, leukotrienes, and platelet activating factor (PAF) are produced during parturition. Both fetal and maternal membranes are implicated in this production...
  64. METALLOTHIONEIN IN REPRODUCTION AND DEVELOPMENT
    Glen Andrews; Fiscal Year: 2002
    ..expressed in specific cell-types that surround the developing embryo from the time of implantation to near parturition, as well as in metal-treated reimplantation blastocysts and in fetal hepatocyte at midgestation...
  65. Polymorphisms in IL-10 Locus Predispose to Preterm Birth
    Surendra Sharma; Fiscal Year: 2006
    ..Proinflammatory cytokines such as TNF-a are important in the initiation of parturition. In this context, we hypothesize that IL-10, a potent anti-inflammatory cytokine, is down-regulated in the ..