uterine contraction

Summary

Summary: Contraction of the UTERINE MUSCLE.

Top Publications

  1. ncbi Preterm delivery
    Michael M Slattery
    Department of Obstetrics and Gynaecology, National University of Ireland Galway, Clinical Science Institute, University College Hospital Galway, Galway, Ireland
    Lancet 360:1489-97. 2002
  2. ncbi Use of the electrohysterogram signal for characterization of contractions during pregnancy
    H Leman
    Department of Biomedical Engineering, Compiègne University, France
    IEEE Trans Biomed Eng 46:1222-9. 1999
  3. ncbi Are animal models relevant to key aspects of human parturition?
    Bryan F Mitchell
    Department of Obstetrics and Gynecology, Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Regul Integr Comp Physiol 297:R525-45. 2009
  4. ncbi Insights into the uterus
    Susan Wray
    Department of Physiology, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Exp Physiol 92:621-31. 2007
  5. pmc miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor
    Nora E Renthal
    Department of Biochemistry, North Texas March of Dimes Birth Defects Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:20828-33. 2010
  6. ncbi Quantitative analysis of contraction patterns in electrical activity signal of pregnant uterus as an alternative to mechanical approach
    Janusz Jezewski
    Department of Biomedical Informatics, Institute of Medical Technology and Equipment, Zabrze, Poland
    Physiol Meas 26:753-67. 2005
  7. ncbi The parturition defect in steroid 5alpha-reductase type 1 knockout mice is due to impaired cervical ripening
    M S Mahendroo
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9032, USA
    Mol Endocrinol 13:981-92. 1999
  8. ncbi Distribution, expression and functional effects of small conductance Ca-activated potassium (SK) channels in rat myometrium
    Karen Noble
    Department of Physiology, University of Liverpool, UK
    Cell Calcium 47:47-54. 2010
  9. ncbi A review of recent insights into the role of the sarcoplasmic reticulum and Ca entry in uterine smooth muscle
    Karen Noble
    Department of Physiology, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L693BX, UK
    Eur J Obstet Gynecol Reprod Biol 144:S11-9. 2009
  10. ncbi Estimation of internal uterine pressure by joint amplitude and frequency analysis of electrohysterographic signals
    Chiara Rabotti
    Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Physiol Meas 29:829-41. 2008

Detail Information

Publications252 found, 100 shown here

  1. ncbi Preterm delivery
    Michael M Slattery
    Department of Obstetrics and Gynaecology, National University of Ireland Galway, Clinical Science Institute, University College Hospital Galway, Galway, Ireland
    Lancet 360:1489-97. 2002
    ..An improved understanding of the physiological pathways that regulate uterine contraction and relaxation in animals and people has, however, helped to define the complex processes that underlie ..
  2. ncbi Use of the electrohysterogram signal for characterization of contractions during pregnancy
    H Leman
    Department of Biomedical Engineering, Compiègne University, France
    IEEE Trans Biomed Eng 46:1222-9. 1999
    ..These results are encouraging, because they would permit, in a follow-up medical study, to diagnose a possible preterm delivery, as well as the proximity of the delivery...
  3. ncbi Are animal models relevant to key aspects of human parturition?
    Bryan F Mitchell
    Department of Obstetrics and Gynecology, Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Regul Integr Comp Physiol 297:R525-45. 2009
    ..We conclude that the application of novel concepts and new models are required to advance translational research in parturition...
  4. ncbi Insights into the uterus
    Susan Wray
    Department of Physiology, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Exp Physiol 92:621-31. 2007
    ..It is only by gaining a better understanding of uterine physiology and pathophysiology that progress will be made and research findings translated into clinical benefit for women and their families...
  5. pmc miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor
    Nora E Renthal
    Department of Biochemistry, North Texas March of Dimes Birth Defects Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:20828-33. 2010
    ....
  6. ncbi Quantitative analysis of contraction patterns in electrical activity signal of pregnant uterus as an alternative to mechanical approach
    Janusz Jezewski
    Department of Biomedical Informatics, Institute of Medical Technology and Equipment, Zabrze, Poland
    Physiol Meas 26:753-67. 2005
    Monitoring of uterine contraction activity is an important diagnostic tool used during both pregnancy and labour. The strain the pregnant uterus exerts on the maternal abdomen is measured via external tocography...
  7. ncbi The parturition defect in steroid 5alpha-reductase type 1 knockout mice is due to impaired cervical ripening
    M S Mahendroo
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9032, USA
    Mol Endocrinol 13:981-92. 1999
    ....
  8. ncbi Distribution, expression and functional effects of small conductance Ca-activated potassium (SK) channels in rat myometrium
    Karen Noble
    Department of Physiology, University of Liverpool, UK
    Cell Calcium 47:47-54. 2010
    ..They contribute more to quiescence that BK channels...
  9. ncbi A review of recent insights into the role of the sarcoplasmic reticulum and Ca entry in uterine smooth muscle
    Karen Noble
    Department of Physiology, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L693BX, UK
    Eur J Obstet Gynecol Reprod Biol 144:S11-9. 2009
    ....
  10. ncbi Estimation of internal uterine pressure by joint amplitude and frequency analysis of electrohysterographic signals
    Chiara Rabotti
    Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Physiol Meas 29:829-41. 2008
    Monitoring the uterine contraction provides important prognostic information during pregnancy and parturition. The existing methods employed in clinical practice impose a compromise between reliability and invasiveness...
  11. ncbi The physiological basis of uterine contractility: a short review
    S Wray
    The Physiological Laboratory, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Exp Physiol 86:239-46. 2001
    ..Much current experimental focus is on pathways controlling and regulating contraction, and we discuss sensitisation mechanisms and question their role in intact uterine preparations. Experimental Physiology (2001) 86.2, 239-246...
  12. pmc Lipid rafts, the sarcoplasmic reticulum and uterine calcium signalling: an integrated approach
    Karen Noble
    Department of Physiology, University of Liverpool, Crown Street, Liverpool, L69 3BX, UK
    J Physiol 570:29-35. 2006
    ....
  13. pmc Surfactant protein secreted by the maturing mouse fetal lung acts as a hormone that signals the initiation of parturition
    Jennifer C Condon
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:4978-83. 2004
    ..We have revealed a response pathway that ties augmented surfactant production by the maturing fetal lung to the initiation of labor. We suggest that SP-A secreted by the fetal lung serves as a hormone of parturition...
  14. ncbi Sonographic measurement of cervical length in twin pregnancies in threatened preterm labor
    I Fuchs
    Virchow Clinic Charité, Berlin, Germany
    Ultrasound Obstet Gynecol 23:42-5. 2004
    ..To determine whether sonographic measurement of cervical length in twin pregnancies presenting with threatened preterm labor helps distinguish between true and false labor...
  15. ncbi Increased cholesterol decreases uterine activity: functional effects of cholesterol alteration in pregnant rat myometrium
    R D Smith
    Dept of Physiology, The University of Liverpool, Crown St, Liverpool, L69 3BX, UK
    Am J Physiol Cell Physiol 288:C982-8. 2005
    ..It may be one of the mechanisms operating to maintain uterine quiescence throughout gestation and may also contribute to difficulties in labor suffered by obese women...
  16. ncbi Effect of inhibiting the sarcoplasmic reticulum on spontaneous and oxytocin-induced contractions of human myometrium
    S Kupittayanant
    The Physiological Laboratory, The University of Liverpool, UK
    BJOG 109:289-96. 2002
    ..to evaluate the contribution of calcium induced calcium release or ryanodine gated calcium channels to myometrial force production...
  17. ncbi A validation of electrohysterography for uterine activity monitoring during labour
    Benoit C Jacod
    Department of Obstetrics, University Medical Centre, Utrecht, The Netherlands
    J Matern Fetal Neonatal Med 23:17-22. 2010
    ..Validation of electrohysterography (EHG) as a method for uterine activity monitoring during labour by comparing with intra-uterine pressure catheter (IUPC) recordings...
  18. pmc G protein-coupled estrogen receptor 1-mediated effects in the rat myometrium
    Andrei A Tica
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Am J Physiol Cell Physiol 301:C1262-9. 2011
    ..Taken together, our results indicate that GPER is expressed and functional in rat myometrium. GPER activation produces depolarization, elevates [Ca(2+)](i) and increases contractility in myometrial cells...
  19. ncbi Patterns of electrical propagation in the intact pregnant guinea pig uterus
    Wim J E P Lammers
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    Am J Physiol Regul Integr Comp Physiol 294:R919-28. 2008
    ..2 +/- 0.9 min). In conclusion, high resolution electrical mapping of the intact pregnant uterus reveals fundamental properties in spatial and temporal patterns of spike and burst propagation that determine the contraction of the organ...
  20. ncbi Physiological pathways and molecular mechanisms regulating uterine contractility
    Hector N Aguilar
    Department of Physiology, University of Alberta, Edmonton, Alberta, Canada
    Hum Reprod Update 16:725-44. 2010
    ..Abnormal contractility might underlie common and important disorders such as infertility, implantation failure, dysmenorrhea, endometriosis, spontaneous miscarriage or preterm birth...
  21. ncbi Evidence that corticotropin-releasing hormone modulates myometrial contractility during human pregnancy
    Elisa K Tyson
    Department of Endocrinology, Mothers and Babies Research Centre, John Hunter Hospital, New Lambton Heights, Newcastle 2305, Australia
    Endocrinology 150:5617-25. 2009
    ..PDE inhibition potentiates CRH and salbutamol-induced relaxation. Up-regulation of PDEs, through chronic cAMP elevation by CRH, could provide a mechanism for down-regulation of agonist-stimulated-cAMP pathways at term...
  22. ncbi Effect of an oxytocin receptor antagonist and rho kinase inhibitor on the [Ca++]i sensitivity of human myometrium
    Nicola A Woodcock
    Department of Biological Sciences, University of Warwick, Walsgrave Hospital, Coventry, United Kingdom, UK
    Am J Obstet Gynecol 190:222-8. 2004
    ..The purpose of this study was to assess the possible mechanism and effect of oxytocin receptor on the sensitization of the contractile proteins to [Ca(++)](i)...
  23. ncbi Uterine contraction induced by Tanzanian plants used to induce abortion
    Tine Nikolajsen
    Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, 2 Universitetsparken, 2100 Copenhagen O, Denmark
    J Ethnopharmacol 137:921-5. 2011
    ..Women in Tanzania use plants to induce abortion. It is not known whether the plants have an effect...
  24. pmc Diabetes is associated with impairment of uterine contractility and high Caesarean section rate
    S Al-Qahtani
    Department of Molecular and Cellular Physiology, Institute of Translational Medicine, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Diabetologia 55:489-98. 2012
    ..We have tested the hypothesis that poor myometrial contractility as a consequence of the disease contributes to this high CS rate...
  25. pmc Uterotonic plants and their bioactive constituents
    Christian W Gruber
    Department of Pharmacognosy, University of Vienna, Vienna, Austria
    Planta Med 77:207-20. 2011
    ..Finally we will comment on the discovery of novel cyclotide-producing plant species and the possibility for the development of novel plant-derived uterotonic and tocolytic drugs...
  26. ncbi Uterine peristaltic activity during the menstrual cycle: characterization, regulation, function and dysfunction
    Georg Kunz
    Department of Obstetrics and Gynaecology and Reproductive Medicine, Klinikum Darmstadt, Academic Teaching Hospital to the Universities of Frankfurt and Heidelberg Mannheim, Grafenstr 9, 64283 Darmstadt, Germany
    Reprod Biomed Online 4:5-9. 2002
    ....
  27. ncbi The contribution of Kv7 channels to pregnant mouse and human myometrial contractility
    Laura A McCallum
    Maternal and Fetal Research Unit, Division of Reproduction and Endocrinology, King s College London, St Thomas Hospital Campus, London, UK
    J Cell Mol Med 15:577-86. 2011
    ..Consequently, activation of the encoded channels represents a novel mechanism for treatment of preterm labour...
  28. pmc The role of voltage-gated potassium channels in the regulation of mouse uterine contractility
    Ryan C Smith
    epartment of Pharmacology, Creighton University Medical Center, Omaha, USA, NE 68178, USA
    Reprod Biol Endocrinol 5:41. 2007
    ....
  29. ncbi Electrophysiological characterization and functional importance of calcium-activated chloride channel in rat uterine myocytes
    K Jones
    Department of Physiology, The University of Liverpool, Liverpool, L69 3BX, UK
    Pflugers Arch 448:36-43. 2004
    ....
  30. pmc Overexpression of SK3 channels dampens uterine contractility to prevent preterm labor in mice
    Stephanie L Pierce
    Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA
    Biol Reprod 78:1058-63. 2008
    ..Our data indicate that SK3 channels must be downregulated for the gravid uterus to generate labor contractions sufficient for delivery in both term and preterm mice...
  31. ncbi The effects of inhibiting Rho-associated kinase with Y-27632 on force and intracellular calcium in human myometrium
    S Kupittayanant
    Department of Physiology, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Pflugers Arch 443:112-4. 2001
    ..This suggests that the Rho-A-ROK pathway may not be a potent modulator of force in the human myometrium under physiological conditions...
  32. pmc Hyperpolarization and slowing of the rate of contraction in human uterus in pregnancy by prostaglandins E2 and f2alpha: involvement of the Na+ pump
    H C Parkington
    Department of Physiology, Monash University, Clayton, Victoria 3168 and Department of Perinatal Medicine, Royal Women s Hospital, Carlton, Victoria 3053, Australia
    J Physiol 514:229-43. 1999
    ..Its persistence at this time ensures complete relaxation between each single robust contraction, preventing spasm of the uterus that would restrict blood flow to the fetus during delivery...
  33. ncbi Poor uterine contractility in obese women
    J Zhang
    Department of Physiology, University of Liverpool, Liverpool, UK
    BJOG 114:343-8. 2007
    ..2) The myometrium from obese women has less ability to contract in vitro...
  34. ncbi Myometrial expression of small conductance Ca2+-activated K+ channels depresses phasic uterine contraction
    Amber Brown
    Dept of Physiology, College of Medicine, Univ of South Alabama, 307 University Blvd, MSB 3074, Mobile, AL 36688, USA
    Am J Physiol Cell Physiol 292:C832-40. 2007
    ..Our findings suggest that SK3 channels play an important role in regulating uterine function by limiting influx through L-type Ca(2+) channels and disrupting the development of concerted phasic contractile events...
  35. pmc Relationship between gene expression and function of uterotonic systems in the rat during gestation, uterine activation and both term and preterm labour
    Patrice Arthur
    Perinatal Research Centre, Department of Obstetrics and Gynaecology, 220 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    J Physiol 586:6063-76. 2008
    ..This novel combination of functional and genetic expression analyses provides new insight into the physiology of parturition...
  36. ncbi Endocrine and paracrine regulation of birth at term and preterm
    - Challis JRG
    Department of Physiology University of Toronto, Ontario, Canada
    Endocr Rev 21:514-50. 2000
    ....
  37. ncbi Calcium-activated chloride currents prolongs the duration of contractions in pregnant rat myometrial tissue
    Roger C Young
    Department of Obstetrics and Gynecology, University of Vermont, Burlington, Vermont 05405, USA
    Reprod Sci 16:734-9. 2009
    ..Taken together, our data suggest that blocking L-type calcium channels reduces impulse directly by reducing peak force, and indirectly by reducing activation of I(Cl(Ca)) , which shortens the duration of the contraction...
  38. ncbi Non-invasive transabdominal uterine electromyography correlates with the strength of intrauterine pressure and is predictive of labor and delivery
    H Maul
    Division of Reproductive Sciences, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas, USA
    J Matern Fetal Neonatal Med 15:297-301. 2004
    ....
  39. ncbi Anatomical differences in uterine sensitivity to prostaglandin F(2alpha) and serotonin in non-pregnant rats
    Martha V Oropeza
    Unidad de Investigacion en Farmacologia, Hospital de Especialidades, CMN Siglo XXI, Instituto Mexicano del Seguro Social, Apdo Postal 73 032, Mexico 03020, D F, Mexico
    Eur J Pharmacol 446:161-6. 2002
    ..Anatomical differences between ovarian and cervical uterine regions modulate the hormonal regulation of uterine sensitivity to serotonin and prostaglandin F(2alpha) in the non-pregnant rat uterus...
  40. ncbi Foetal heart rate power spectrum response to uterine contraction
    M Romano
    Biomedical Engineering Unit Electronics and Telecommunications Engineering Department, University Federico II of Naples, Via Claudio, 21, 80125, Napoli, Italy
    Med Biol Eng Comput 44:188-201. 2006
    ..b>Uterine contraction being a strong stimulus for the foetus and its autonomic nervous system, it is worth exploring the FHR ..
  41. ncbi Contractility and calcium signaling of human myometrium are profoundly affected by cholesterol manipulation: implications for labor?
    - Jie Zhang
    University of Liverpool, Liverpool, UK
    Reprod Sci 14:456-66. 2007
    ..Cholesterol may contribute to uterine quiescence but could cause difficulties in labor in obese/dyslipidemic women, consistent with their increased cesarean delivery rates...
  42. ncbi The effects of wild ginger (Costus speciosus (Koen) Smith) rhizome extract and diosgenin on rat uterine contractions
    Wanwisa Lijuan
    Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, Thailand
    Reprod Sci 18:516-24. 2011
    ..Wild ginger was able to increase contraction via calcium entry on l-type calcium channels and sarcoplasmic reticulum (SR) calcium release. We suggest that wild ginger rhizome extract may be a useful uterine stimulant...
  43. ncbi Mechanisms of uterine contractility in laying hens
    S Kupittayanant
    School of Physiology, Institute of Science, Suranaree University of Technology, University Avenue, Nakhon Ratchasima 30000, Thailand
    Anim Reprod Sci 115:215-24. 2009
    ....
  44. ncbi Uterine contractility and embryo implantation
    Carlo Bulletti
    Department of Reproduction Physiopathology, Rimini General Hospital and University of Bologna, Rimini, Italy
    Curr Opin Obstet Gynecol 17:265-76. 2005
    ..The aim of this article is to assess the importance of uterine contractility in the implantation of human embryos...
  45. pmc Expression of cystathionine β-synthase and cystathionine γ-lyase in human pregnant myometrium and their roles in the control of uterine contractility
    Xing Ji You
    Department of Physiology, Second Military Medical University, Shanghai, China
    PLoS ONE 6:e23788. 2011
    ..Hydrogen sulfide (H(2)S) has recently been shown to play a key role in the control of smooth muscle tension. The role of endogenous H(2)S produced locally in the control of uterine contractility during labour is unknown...
  46. ncbi Oxytocin inhibiting effect of the aqueous leaf extract of Ficus exasperata (Moraceae) on the isolated rat uterus
    Enitome E Bafor
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Benin City 300001, Nigeria
    Acta Pol Pharm 68:541-7. 2011
    ..exasperata inhibits oxytocin-induced uterine contractions at the concentration shown in this study. This observation may explain its folkloric use in counteracting preterm contractions and alleviating dysmenorrhoea...
  47. ncbi Corticotropin-releasing hormone effects on human pregnant vs. nonpregnant myometrium explants estimated from a mathematical model of uterine contraction
    Thérèse Marie Mignot
    Génétique et Epigénétique des Pathologies Placentaires INSERM U 709, IFR Alfred Jost, Universite Rene Descartes Paris V, Pavillon Baudelocque, 123 Boulevard de Port Royal 75014, Paris, France
    J Appl Physiol 99:1157-63. 2005
    In this paper, we applied a new theoretical model of uterine contraction to a large panel of human pregnant and nonpregnant myometrial strips, treated or not by corticotrophin-releasing hormone (CRH)...
  48. ncbi Differences in muscarinic-receptor agonist-, oxytocin-, and prostaglandin-induced uterine contractions
    Ralf Dittrich
    Department of Obstetrics and Gynecology, Erlangen University Hospital, University of Erlangen Nuremberg, Erlangen, Germany
    Fertil Steril 92:1694-700. 2009
    ..To investigate the contractile response of the perfused swine uterus to various receptor pathways (oxytocin, prostaglandins, and muscarine)...
  49. ncbi Sonographic assessment of the cervix before, during and after a uterine contraction is effective in predicting the course of labor
    M Saito
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Ultrasound Obstet Gynecol 22:604-8. 2003
    To investigate whether the degree of change in cervical length during a uterine contraction is predictive of subsequent progression of labor.
  50. ncbi Characterization of abdominally acquired uterine electrical signals in humans, using a non-linear analytic method
    William L Maner
    Department of Obstetrics and Gynecology, Division of Reproductive Sciences, University of Texas Medical Branch, 301 University Route 1062, Galveston, TX 77555, USA
    Med Biol Eng Comput 44:117-23. 2006
    ..frequency range and then randomly selecting "bursts" of uterine electrical activity (each associated with a uterine contraction) from every recording...
  51. ncbi Modulation of uterine contractility and peristalsis by oxytocin in estrogen-primed non-pregnant swine uteri
    Andreas Muller
    Department of Obstetrics and Gynecology, Erlangen University Hospital, Universitaetsstr 21 23, D 91054 Erlangen, Germany
    Eur J Med Res 11:157-62. 2006
    ..The biological role of oxytocin increase during sexual stimulation and arousal with a peak during orgasm for the mechanisms of reproduction may be to stimulate directed uterine transport mechanisms in the presence of estrogens...
  52. ncbi Oxytocic effects of the aqueous leaf extract of Costus lucanusianus - family Costaceae on isolated non-pregnant rat uterus
    Omonkhelini J Owolabi
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Nigeria
    Pak J Pharm Sci 23:207-11. 2010
    ..An effect of 0.63+/-0.06 g force of uterine contraction produced by 12.5 mg of the extract was increased to 1.37+/-0...
  53. ncbi The effects of pomegranate seed extract and beta-sitosterol on rat uterine contractions
    Wilawan Promprom
    Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, Thailand
    Reprod Sci 17:288-96. 2010
    ..We suggest that pomegranate extract and beta-sitosterol may be a useful uterine stimulant...
  54. ncbi Frequency of uterine contractions and the risk of spontaneous preterm delivery
    Jay D Iams
    Department of Obstetrics and Gynecology at Ohio State University, Columbus 43210 1228, USA
    N Engl J Med 346:250-5. 2002
    ..The measurement of the frequency of uterine contractions has not been useful for reducing the rate of preterm delivery in randomized trials. Nonetheless, ambulatory monitoring of contractions continues to be used in clinical practice...
  55. ncbi The effects of bupivacaine, ropivacaine and mepivacaine on the contractility of rat myometrium
    G Arici
    Akdeniz University Faculty of Medicine, Departments of Anesthesiology and Reanimation, Antalya, Turkey
    Int J Obstet Anesth 13:95-8. 2004
    ..Bupivacaine, ropivacaine and mepivacaine were found to have no effect on frequency of uterine contractions. These results demonstrate that bupivacaine and ropivacaine may inhibit myometrium contractility...
  56. ncbi Calcium homeostatic pathways change with gestation in human myometrium
    R M Tribe
    The London Myometrial Group, Fetal Health Research Group, Department of Obstetrics and Gynaecology, Guy s, King s and St Thomas School of Medicine, St Thomas Hospital, London SE1 7EH, United Kingdom
    Biol Reprod 63:748-55. 2000
    ..We conclude that the activity of SERCA isoforms becomes increasingly important in the maintenance of regular contractile activity during labor and may compensate for the functional loss of other calcium control pathways at term...
  57. ncbi Evaluation of tocolytic activity of ethanol extract of the stem bark of Ficus capensis Thunb. (Moraceae)
    Omonkhelin J Owolabi
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Benin City, Edo State, Nigeria
    Acta Pol Pharm 66:293-6. 2009
    ....
  58. ncbi Steroid hormone control of myometrial contractility and parturition
    Sam Mesiano
    Department of Reproductive Biology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 5034, United States
    Semin Cell Dev Biol 18:321-31. 2007
    ..This review addresses current understanding of how progesterone and estrogens affect the contractility of the pregnancy myometrium and how their actions are coordinated and controlled as part of the parturition cascade...
  59. ncbi Myometrial response to neurotropic and musculotropic spasmolytic drugs in an extracorporeal perfusion model of swine uteri
    J Kunzel
    Department of Gynaecology, Erlangen University Hospital, Erlangen, Germany
    Reprod Biomed Online 23:132-40. 2011
    ..Denaverine and pethidine in particular may in the future be able to play an important role in improving the pregnancy rate after IVF...
  60. pmc Expression of ATP-sensitive potassium channels in human pregnant myometrium
    Chen Xu
    Department of Physiology, Second Military Medical University, Shanghai 200433, China
    Reprod Biol Endocrinol 9:35. 2011
    ..The objectives of this study were to investigate the protein expression of KATP channel in human myometrium and determine the levels of KATP channel in lower and upper segmental myometrium before and after onset of labour...
  61. ncbi Relaxation of myometrium by calcitonin gene-related peptide is independent of nitric oxide synthase activity in mouse uterus
    M Naghashpour
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33101, USA
    Biol Reprod 63:1421-7. 2000
    ..No correlation between NOS expression and inhibitory activity of CGRP was evident. The results suggest that the inhibitory action of CGRP in the mouse uterus is independent of the activity of these NOS isoforms...
  62. pmc A role of stretch-activated potassium currents in the regulation of uterine smooth muscle contraction
    Iain L O Buxton
    Myometrial Research Laboratory, University of Nevada School of Medicine, Reno, Nevada 89557 0573, USA
    Acta Pharmacol Sin 32:758-64. 2011
    ....
  63. ncbi The effect of fennel essential oil on uterine contraction as a model for dysmenorrhea, pharmacology and toxicology study
    S N Ostad
    Department of Toxicology and Pharmacology, Faculty of Pharmacy, University of Tehran Medical Sciences, PO Box 14155 6451, Tehran, Iran
    J Ethnopharmacol 76:299-304. 2001
    ..In this article, effects of FEO on the uterine contraction and estimation of LD(50) in rat were described...
  64. pmc Poor spontaneous and oxytocin-stimulated contractility in human myometrium from postdates pregnancies
    Sarah Arrowsmith
    Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 7:e36787. 2012
    ..We show that postdates pregnancy is associated with poor myometrial activity and suggest that this may contribute to increased myometrial quiescence and hence, prolonged gestation...
  65. ncbi In vitro myometrial contractility reflects indication for caesarean section
    S Quenby
    Clinical Sciences Research Institute, University of Warwick, Coventry, UK
    BJOG 118:1499-506. 2011
    ..To assess the extent to which in vitro measurements of myometrial contractility reflect the clinical indication for caesarean section...
  66. ncbi Uterine contractility in response to different prostaglandins: results from extracorporeally perfused non-pregnant swine uteri
    Andreas Mueller
    Department of Obstetrics and Gynaecology, Erlangen University Hospital, Erlangen, Germany
    Hum Reprod 21:2000-5. 2006
    ..The goal of this study was to assess dynamic changes in uterine contractility and peristalsis in response to PGs in comparison with the effects of oxytocin administration...
  67. ncbi Expression of Gsalpha, connexin-43, connexin-26, and EP1, 3, and 4 receptors in myometrium of prelabor singleton versus multiple gestations and the effects of mechanical stretch and steroids on Gsalpha
    Fiona Lyall
    Institute of Medical Genetics, Yorkhill, Glasgow, United Kingdom
    J Soc Gynecol Investig 9:299-307. 2002
    ....
  68. ncbi Home uterine activity monitoring: an evidence review of its utility in multiple gestations
    James P Reichmann
    J Reprod Med 54:559-62. 2009
    ..To examine the medical evidence regarding the application of home uterine activity monitoring for multiple gestations...
  69. pmc Possible role of the protein kinase C/CPI-17 pathway in the augmented contraction of human myometrium after gestation
    Hiroshi Ozaki
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, Yayoi 1 1 1, Tokyo 113 8657, Japan
    Br J Pharmacol 140:1303-12. 2003
    ..6. These results suggest that the PKC-mediated contractile mechanism is augmented in human myometrium after gestation, and that this augmentation may be attributable to the increased activity of the beta PKC isoform and CPI-17...
  70. ncbi Uterine activity monitoring during labor
    Petra C A M Bakker
    Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands
    J Perinat Med 35:468-77. 2007
    ..The need for correct assessment and interpretation of the uterine contraction curve to improve fetal outcome will be emphasized.
  71. ncbi Frequency of uterine contractions in asymptomatic pregnant women with or without a short cervix on transvaginal ultrasound scan
    Vincenzo Berghella
    Departments of Obstetrics and Gynecology at Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, USA
    Am J Obstet Gynecol 191:1253-6. 2004
    ....
  72. ncbi Ca2+ entry, efflux and release in smooth muscle
    A Matthew
    Department of Physiology, The University of Liverpool, Liverpool L69 3BX, UK
    Biol Res 37:617-24. 2004
    ..This phosphorylates myosin and force results. Without Ca2+ entry uterine contraction fails...
  73. ncbi Uterine contractility evaluated on cine magnetic resonance imaging
    Kaori Togashi
    Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Ann N Y Acad Sci 1101:62-71. 2007
    ....
  74. ncbi Uterine peristalsis shown on cine MR imaging using ultrafast sequence
    Asako Nakai
    Department of Nuclear Medicine and Diagnostic Imaging, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Magn Reson Imaging 18:726-33. 2003
    ..To demonstrate and evaluate uterine peristalsis on cine magnetic resonance imaging (MRI) using ultrafast imaging...
  75. ncbi Antepartum uterine contraction patterns in twin pregnancies with and without preterm labor and delivering before or after 36 weeks
    Ana Rachel Hernández
    Department of Obstetrics and Gynecology, University of Miami, Miami, FL 33101, USA
    Am J Obstet Gynecol 198:e28-9. 2008
    The purpose of this study was to identify differences in antepartum uterine contraction frequency (UCF) in twin pregnancies with and without preterm labor (PTL).
  76. ncbi Investigation of uterine peristalsis diurnal variation
    Aki Kido
    Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Magn Reson Imaging 24:1149-55. 2006
    ..However, nothing is known as regarding diurnal variations. This study was designed to evaluate for the presence of a diurnal variation in uterine peristalsis...
  77. ncbi Preterm labour. Myometrial function in prematurity
    Andrew M Blanks
    Clinical Sciences Research Institute, University of Warwick, University Hospitals of Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, UK
    Best Pract Res Clin Obstet Gynaecol 21:807-19. 2007
    ..Lastly, we consider the actions of the commonly accepted uterine agonists oxytocin, prostaglandin F(2alpha), and prostaglandin E(2), and the tocolytic ritodrine...
  78. ncbi The role of cyclic-ADP-ribose-signaling pathway in oxytocin-induced Ca2+ transients in human myometrium cells
    Hosana Barata
    Signal Transduction Laboratory, Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Endocrinology 145:881-9. 2004
    Human myometrial contraction plays a fundamental role in labor. Dysfunction of uterine contraction is an important cause of labor progression failure...
  79. ncbi Uterine contraction frequency during treatment of pyelonephritis in pregnancy and subsequent risk of preterm birth
    Lynnae K Millar
    Kapiolani Medical Center for Women and Children, John A Burns School of Medicine, University of Hawaii at Manoa, 1319 Punahou Street, Room 540 Honolulu, Hawaii 96826
    J Perinat Med 31:41-6. 2003
    To assess ceftriaxones effect on uterine contraction frequency and determine risk factors for subsequent preterm birth in women with pyelonephritis.
  80. ncbi In vitro effects of endothelin-1 on the contractility of myometrium obtained from pre- and postmenopausal women
    E Domali
    Department of Obstetrics and Gynecology, University of Thessalia, 22 Papakiriazi Street, 41222 Larissa, Greece
    J Endocrinol 168:153-62. 2001
    ..It is suggested that KCl and ET1 affect uterine contractility through different mechanisms and that ovarian steroids may play a regulatory role in human uterine responsiveness to ET1...
  81. ncbi Uterine contraction pattern as a predictor of the mode of delivery
    Lawrence W Oppenheimer
    Division of Perinatology, Ottawa General Hospital, Ottawa, Ontario, Canada
    J Perinatol 22:149-53. 2002
    ..To determine whether analysis of the frequency or regularity of uterine contractions can distinguish between women delivering vaginally and women requiring Cesarean section for dystocia...
  82. ncbi Receptor-coupled contractility of uterine smooth muscle: from membrane to myofilaments
    Y H Lee
    Department of Physiology, Yonsei University College of Medicine, Seoul, South Korea
    Exp Physiol 86:283-8. 2001
    A comprehensive understanding of the mechanisms by which agonists control uterine contraction is essential for the successful clinical management of parturition and for the timely treatment of situations involving inappropriate uterine ..
  83. ncbi Excessive uterine contractions: effect on the incidence of preterm delivery in twin gestation
    John C Morrison
    Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson 39216, USA
    J Reprod Med 50:923-7. 2005
    ..To evaluate the effect of uterine contractions on the incidence of preterm delivery within 7 and 14 days in twin pregnancies...
  84. ncbi Role of estrogen and progesterone in the regulation of uterine peristalsis: results from perfused non-pregnant swine uteri
    A Mueller
    Department of Obstetrics and Gynecology, University Hospital Erlangen, Erlangen, Germany
    Hum Reprod 21:1863-8. 2006
    ..Estrogen and progesterone fluctuate characteristically during the menstrual cycle. It has been suggested that both hormones influence uterine peristalsis in characteristic ways...
  85. pmc Simultaneous measurements of changes in sarcoplasmic reticulum and cytosolic
    A V Shmigol
    Department of Physiology, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    J Physiol 531:707-13. 2001
    ..Spontaneous activity was inhibited when [Ca2+]L was increased. 5. These data show that it is possible to simultaneously measure SR and cytosolic [Ca2+], and to investigate their response to agonist application and spontaneous activity...
  86. ncbi Gestational changes in uterine L-type calcium channel function and expression in guinea pig
    P L Collins
    Departments of Obstetrics Gynecology, Pediatrics, Biochemistry, and the Rammelcamp Center for Research, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio 44109, USA
    Biol Reprod 63:1262-70. 2000
    ..The up-regulation of function, alpha(1c) subunit mRNA expression, and isradipine binding at term gestation are consistent with a role for this ion channel in parturition...
  87. ncbi Dysfunctional labor and myometrial lactic acidosis
    Siobhan Quenby
    Department of Obstetrics and Gynaecology, University of Liverpool, Liverpool, United Kingdom
    Obstet Gynecol 103:718-23. 2004
    ..Following in vitro studies that showed acidification could depress uterine contraction, we hypothesized that it could contribute to dysfunctional labors.
  88. ncbi RhoA/Rho-kinase cascade is involved in oxytocin-induced rat uterine contraction
    Masahiro Tahara
    Osaka University Graduate School of Medicine, Department of Obstetrics and Gynecology, Suita, Osaka 565 0871, Japan
    Endocrinology 143:920-9. 2002
    ..We examined the potential role of this pathway in oxytocin-induced uterine contraction. The specific Rho-kinase inhibitor Y-27632 inhibited oxytocin-induced rat uterine contraction on d 21 of ..
  89. ncbi Oxytocin and lysophosphatidic acid induce stress fiber formation in human myometrial cells via a pathway involving Rho-kinase
    W Gogarten
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Biol Reprod 65:401-6. 2001
    ..Rho-kinase appears to be a key signaling factor in this pathway...
  90. ncbi Proposed biological linkages between obesity, stress, and inefficient uterine contractility during labor in humans
    Nancy K Lowe
    Division of Women, Children, and Family Health, University of Colorado Denver, 13120 E 19th Avenue, Mail Stop 288 18, Aurora, CO 80045, USA
    Med Hypotheses 76:755-60. 2011
    ....
  91. ncbi Corticotropin-releasing hormone acts on CRH-R1 to inhibit the spontaneous contractility of non-labouring human myometrium at term
    Lan Mei Zhang
    Department of Gynecology and Obstetric, Changhai Hospital, Second Military Medical University, Shanghai 200433, PR China
    Life Sci 83:620-4. 2008
    ..The aims of the present study were to explore effects of CRH on contractility of human term myometrium and compare these effects in labouring and non-labouring myometrial strips...
  92. ncbi RHO protein regulation of contraction in the human uterus
    J Lartey
    Medical School, Institute of Cellular Medicine, University of Newcastle, 3rd Floor, William Leech Building, Framlington Place, Newcastle upon Tyne NE24HH, UK
    Reproduction 138:407-24. 2009
    ....
  93. ncbi Changes of the uterine proteoglycan distribution at term pregnancy and during labour
    Ann M Hjelm
    Department of Woman and Child Health Division for Obstetrics and Gynecology, Karolinska Institute Karolinska Hospital, P O Box 140, S 171 76, Stockholm, Sweden
    Eur J Obstet Gynecol Reprod Biol 100:146-51. 2002
    ..To characterise uterine proteoglycans and changes therein during pregnancy and labour...
  94. ncbi Myometrial desensitization after ritodrine infusion
    S N Caritis
    Department of Obstetrics and Gynecology, University of Pittsburgh School of Medicine, Magee Womens Hospital, Pennsylvania 15123
    Am J Physiol 253:E410-7. 1987
    ..005). The model thus demonstrates that use of the beta-adrenergic agonist ritodrine in a clinically relevant manner results in tachyphylaxis of its effects on both physiological parameters and the receptor cascade system...
  95. ncbi Role of protein kinase Cbeta in rhythmic contractions of human pregnant myometrium
    Katsuhiko Yasuda
    Department of Obstetrics and Gynecology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi, Osaka 570 8507, Japan
    Reproduction 133:797-806. 2007
    ..These findings suggest that the increased amplitude of human myometrial contractions during pregnancy is related to the increased level of PKCbeta. A PKCbeta inhibitor may reduce preterm uterine contractions and prevent preterm delivery...
  96. ncbi Gestational change of K+ channel opener effect is correlated with the expression of uterine KATP channel subunits
    Kenjiro Sawada
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Eur J Obstet Gynecol Reprod Biol 122:49-56. 2005
    ..We analyzed the gestational changes of pharmacological activity and molecular levels of KATP channels in rat myometrium...
  97. ncbi Effects of L-type Ca(2+)-channel blockade, K(+)(ATP)-channel opening and nitric oxide on human uterine contractility in relation to gestational age and labour
    M Longo
    Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Mol Hum Reprod 9:159-64. 2003
    ..Effects of nitric oxide and Mg(2+) are not affected by gestational age or labour...
  98. pmc Reduced expression of CRH receptor type 1 in upper segment human myometrium during labour
    Binhai Cong
    Department of Physiology, Second Military Medical University, Shanghai, PR China
    Reprod Biol Endocrinol 7:43. 2009
    ..We hypothesized that the expression of CRH receptors in myometrium might be changed during pregnancy and labour...
  99. ncbi Cloning and characterization of a calcium-activated chloride channel in rat uterus
    Junfang Song
    Institute of Genetics and Developmental Biology and State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Biol Reprod 80:788-94. 2009
    ..The identification and characterization of rat Clca4 help decipher the contribution of Ca(2+)-activated Cl(-) conductance in myometrial contractility...
  100. ncbi Stimulation of contractions in human myometrium by serotonin is unmasked by smooth muscle relaxants
    Yolande Cordeaux
    Department of Obstetrics and Gynaecology, University of Cambridge, The Rosie Hospital, Cambridge, UK
    Reprod Sci 15:727-34. 2008
    ..The aim of this study was to investigate the ability of serotonin to increase contractions in human myometrium...
  101. ncbi Effect of melatonin on estrogen and progesterone receptors in relation to uterine contraction in rats
    Adel R A Abd-Allah
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Cairo, Egypt
    Pharmacol Res 47:349-54. 2003
    ..Control animals received the vehicle. The uterus was dissected out and uterine contraction in one horne was recorded in vitro for each animal as a response to oxytocin (0...

Research Grants47

  1. Hamster: a unique model for studying implantation
    BIBHASH CHANDRA PARIA; Fiscal Year: 2013
    ..and in situ hybridization, immunohistochemistry, in vivo adenoviral vector-driven gene inhibition, in vitro uterine contraction studies, and others to accomplish our goals...
  2. Caspase-3 Maintains Uterine Quiescence in a PR and NF-Kappa B Dependent Manner
    Jennifer C Condon; Fiscal Year: 2013
    ..NF-kB inhibits uterine PR action leading to a loss of P4 maintained uterine quiescence and the onset of uterine contraction. In this proposal we test the hypothesis that NF-:B activation and a withdrawal of PR action play a ..
  3. Molecular Mechanism of Allosteric Modulation of the Oxytocin Receptor by Sterols
    VADIM GENNADYEVICH CHEREZOV; Fiscal Year: 2013
    ..a long time, the oxytocin system was linked with supporting two critical reproductive functions in mammals: uterine contraction during labor and milk ejection during lactation...
  4. Role of GRK6-Mediated Oxytocin Receptor Desensitization in Labor
    Chad A Grotegut; Fiscal Year: 2013
    ..K08 proposes to utilize an innovative technique that enables the monitoring of strength and frequency of uterine contraction, and duration of labor in murine models lacking GRK6, an essential mediator of oxytocin receptor ..
  5. REGULATION OF UTERINE SMOOTH MUSCLE EXCITABILITY
    Sarah K England; Fiscal Year: 2010
    ..is supported by our preliminary data showing that maxi-K knockout mice exhibit an increased frequency of uterine contraction. In spite of the strong evidence in support of the notion that the maxi-K channel modulates uterine ..
  6. Discerning Pathological and Braxton Hicks Contractions in Mid-Trimester Gestation
    Abimbola J Aina-Mumuney; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: This project will advance uterine contraction monitoring in pregnant women to increase the effectiveness of antenatal surveillance...
  7. ION CHANNELS OF UTERINE MUSCLE DURING PREGNANCY
    Nicholas Sperelakis; Fiscal Year: 1992
    ..The resulting increase in cAMP within the myometrial cell is believed to mediate the inhibition of uterine contraction, by decreasing the availability of free Ca2+...
  8. Spike After-Potentials of Oxytocin Cells in Lactation
    Ryoichi Teruyama; Fiscal Year: 2005
    ..1984) and results in a bolus release of OT into the blood stream, necessary for uterine contraction or contraction of myoepithelial cells in the mammary glands...
  9. ROLE OF ADENYL PURINES IN MYOMETRIAL FUNCTION
    IAIN BUXTON; Fiscal Year: 1993
    ..and ATP from one or more sources stimulate purinergic receptors in myometrial smooth muscle leading to uterine contraction. We propose that adenyl purines participate in, or initiate labor and as such, may provide a focal point ..
  10. FETAL RESPONSIVITY DURING LABOR & BEHAVIORAL OUTCOME
    Eugene Emory; Fiscal Year: 1993
    ..The studies will address 1) statistical/parametric properties of FHR patterns and uterine contraction activity, 2) short-term (1 year) behavioral and temperamental correlates, 3) long-term (13-15 years) ..
  11. RELIABLE NON-INVASIVE UTERINE ACTIVITY MONITOR
    PAGE READ; Fiscal Year: 1991
    The opportunity exists for greatly improving the state of the art of external uterine contraction monitoring through the development of an innovative concept for a new contraction sensor (tocotonometer)...
  12. REGULATION OF MYOMETRIAL CYCLASE ISOTYPE EXPRESSION
    KAREN LINDEMAN; Fiscal Year: 2000
    ..The most important pathways producing uterine contraction and relaxation are OT and bAR-mediated pathways...
  13. Endocannabinoids and Reproductive Pain
    Heather Bradshaw; Fiscal Year: 2005
    ..Specific aim 2 is designed to measure the effect of AEA, 2-AG, and NAGly on uterine contraction rates and amplitudes...
  14. FACTORS RESPONSIBLE FOR THE CONTROL OF HUMAN LABOR
    ROGER YOUNG; Fiscal Year: 2003
    ....
  15. Mechanisms of myometrial healing and regeneration
    Catalin Buhimschi; Fiscal Year: 2006
    ....
  16. PI/PLC FUNCTION IN PREGNANT RAT MYOMETRIUM
    Mark Phillippe; Fiscal Year: 2002
    ..s. ..
  17. PREGNANCY EFFECT ON VASCULAR SMOOTH MUSCLE/ENDOTHELIUM
    Carl Weiner; Fiscal Year: 2005
    ..RT-PCR of mRNA from endothelial and smooth muscle cells obtained by laser capture microdissection will localize the changes. Together, these experiments provide new understanding and avenues to elucidate pregnancy specific diseases. ..
  18. Thrombin-Stimulated Intrauterine Signaling Pathway
    Mark Phillippe; Fiscal Year: 2007
    ..These studies are anticipated to significantly improve our understanding of the mechanisms underlying preterm labor in the presence of intrauterine infection. ..
  19. Prostease-activated receptor-2 in uterine contractility
    Yuri Vedernikov; Fiscal Year: 2004
    ..The potential benefits of these studies include a better understanding of the mechanisms modulating uterine contractility, thereby improving our ability to control it clinically. ..
  20. CHLORHEXIDINE IRRIGATION TO PREVENT INFECTION
    Dwight Rouse; Fiscal Year: 2001
    ....
  21. HEART RATE DURING TRANSITION TO EXTRAUTERINE LIFE
    M Verklan; Fiscal Year: 2001
    ..It is anticipated that the use of this advanced technology will strengthen clinical practice due to an enhanced ability to better evaluate neurophysiologic indicators of stability of both the healthy and compromised fetus and neonate. ..
  22. GenMAPP-CS, a dynamic resource pathway analysis
    Bruce R Conklin; Fiscal Year: 2010
    ..The challenge of analyzing these massive and complex datasets is a major force driving the development of GenMAPP-CS. ..
  23. PROTEIN PHOSPHATASES AND OOCYTE MEIOSIS
    Gary Smith; Fiscal Year: 2002
    ..These studies will provide novel information concerning control of oocyte maturation and spindle formation that may subsequently influence the developmental competency of resulting embryos. ..
  24. Maternal physiological factors influencing labor length
    JEREMY NEAL; Fiscal Year: 2008
    ..Results may offer support to alternative labor management strategies. ..
  25. Molecular Analysis of a Novel Opioid Peptide Transporter
    Vadivel Ganapathy; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  26. Role of Cytokines and Promoter Genotype in Prematurity
    Hyagriv Simhan; Fiscal Year: 2007
    ..abstract_text> ..
  27. COLLABORATIVE R01--ROLES OF G PROTEINS IN CARDIOMYOPATHY
    Bruce Conklin; Fiscal Year: 2002
    ..3. To selectively activate G protein pathways in the setting of two experimentally induced cardiomyopathy models where G protein signaling has been shown to be altered. (End of Abstract) ..
  28. GenMAPP: A tool for pathway analysis of genomic data
    Bruce Conklin; Fiscal Year: 2006
    ..With the completion these aims, GenMAPP 3.0 will provide a program that is robust, simple to use, and available without charge to the entire biological community. [unreadable] [unreadable]..
  29. CARNITINE TRANSPORTERS: STRUCTURE, FUNCTION & REGULATION
    Vadivel Ganapathy; Fiscal Year: 2003
    ..laevis oocytes. The regulation studies will be carried out in intact animals using the rat as a model and also in cultured cells of human origin. ..
  30. Immune Tolerance; Sigma Receptor as a Therapeutic Target
    Vadivel Ganapathy; Fiscal Year: 2003
    ....
  31. Low birth weight, uterine infection, and nitric oxide
    Chandrasekhar Yallampalli; Fiscal Year: 2007
    ..2 will test the hypothesis that NO donor can reverse the increases in DAF expression in uteroplacental and vascular tissues and in fetal growth restriction ..
  32. Cocaine and Apoptosis in the Developing Heart
    Lubo Zhang; Fiscal Year: 2004
    ..Such an understanding has obvious clinical implications because the increasing information has pointed to an important role of apoptosis in cardiovascular diseases. ..
  33. MECHANISMS OF PRETERM LABOR: NF-KB ACTIVATION OF COX-2
    DOUGLAS KNISS; Fiscal Year: 2001
    ....
  34. MIDCAREER AWARD IN PATIENT ORIENTED OBSTETRIC RESEARCH
    Dwight Rouse; Fiscal Year: 2004
    ..Finally, the effectiveness of an intervention (how it would perform under conditions of actual clinical practice) is an attribute that, in many situations, is as important as its efficacy (how it performs under ideal conditions). ..
  35. PURINERGIC AXIS OF CARDIAC BLOOD VESSELS
    IAIN BUXTON; Fiscal Year: 2001
    ..We will approach these aims with biochemical, pharmacological, molecular, cell biological and microscopic methods employing intact blood vessels, cells in primary culture and subcellular fractions. ..
  36. Risk factors for medically indicated preterm birth in a Latin American population
    CLAUDIO GERARDO SOSA; Fiscal Year: 2010
    ..The long-term goal of this research program is to develop intervention strategies that are based on the risk factors identified in the proposed study resulting in decreased morbidity and mortality. ..
  37. Nutrition and the Genetics of Prematurity
    Hyagriv N Simhan; Fiscal Year: 2010
    ..Finally, we aim to identify how race modifies the interaction between inflammatory gene polymorphisms and nutrition on lower genital tract immunity and the risk of preterm birth. ..
  38. Development of Spatial-Temporal Analysis Tools for Uterine Biomagnetic Signals
    Hari Eswaran; Fiscal Year: 2009
    ..This system can record the magnetic field corresponding to the electrical activity of uterine contraction and provide requisite spatial-temporal information...
  39. Uterine Vascular Adaptation to Pregnancy
    Lubo Zhang; Fiscal Year: 2005
    ..Such an understanding has obvious clinical implications because the maladaptation of uterine circulation to pregnancy is associated with fetal developmental abnormalities and maternal cardiovascular disorders. ..
  40. Prenatal Cocaine Exposure and Cardiac Programming
    Lubo Zhang; Fiscal Year: 2009
    ..abstract_text> ..
  41. Antenatal and preschool iron and zinc use and cognition
    Parul Christian; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  42. Compartmental analysis of proteomic biomarkers during intra-uterine infections
    PETA GRIGSBY; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  43. Regulation of the Contraction in Human Uterus
    VICTOR FOMIN; Fiscal Year: 2004
    ..A proper understanding of the mechanisms of uterine contraction and its cellular regulation is essential in finding ways to treat these uterine functional pathologies...
  44. Insulin and Oocyte Chromatin Segregation
    Gary Smith; Fiscal Year: 2009
    ..abstract_text> ..