maternal fetal exchange

Summary

Summary: Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission.

Top Publications

  1. ncbi Comparative developmental anatomy of the murine and human definitive placentae
    P Georgiades
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
    Placenta 23:3-19. 2002
  2. ncbi Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland
    Benjamin J Apelberg
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Environ Sci Technol 41:3891-7. 2007
  3. ncbi Maternal rescue of transforming growth factor-beta 1 null mice
    J J Letterio
    Laboratory of Chemoprevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Science 264:1936-8. 1994
  4. pmc Sex differences in transgenerational alterations of growth and metabolism in progeny (F2) of female offspring (F1) of rats fed a low protein diet during pregnancy and lactation
    E Zambrano
    Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Vasco de Quiroga 15, 14000, Mexico, DF Mexico
    J Physiol 566:225-36. 2005
  5. ncbi Candidate-gene association study of mothers with pre-eclampsia, and their infants, analyzing 775 SNPs in 190 genes
    Katrina A B Goddard
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    Hum Hered 63:1-16. 2007
  6. pmc Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population
    Frederica P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Environ Health Perspect 111:201-5. 2003
  7. ncbi Fish intake during pregnancy and early cognitive development of offspring
    Julie L Daniels
    National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA juliedanielsunc edu
    Epidemiology 15:394-402. 2004
  8. ncbi Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific
    Babak Baban
    Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia 1120, 15th Street, Augusta, GA 30912 2600, USA
    J Reprod Immunol 61:67-77. 2004
  9. ncbi Fetal origins of breast cancer
    Leena Hilakivi-Clarke
    Georgetown University, Washington DC 20057, USA
    Trends Endocrinol Metab 17:340-8. 2006
  10. pmc Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny
    Rosalía Lavado-Autric
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Madrid, Spain
    J Clin Invest 111:1073-82. 2003

Research Grants

  1. Utilizing Ethyl Nitrate Gas in Laparoscopic Surgery
    James Reynolds; Fiscal Year: 2006
  2. MOLECULAR BASIS OF PLACENTAL WATER AND SOLUTE TRANSPORT
    NICHOLAS ILLSLEY; Fiscal Year: 1993
  3. 14th International Society for Prenatal Diagnosis Meeting
    DIANA BIANCHI; Fiscal Year: 2008
  4. DECIDUAL CELL/PLACENTAL INTERACTIONS
    JOAN HUNT; Fiscal Year: 2007
  5. BIOMARKERS OF GENETIC DAMAGE AND ANTIOXIDANT
    Frederica Perera; Fiscal Year: 2001
  6. VULNERABILITY OF THE FETUS/INFANT TO PAH, PM2.5 AND ETS.
    Frederica Perera; Fiscal Year: 2004
  7. STRATEGIES FOR PRIMATE TRANSGENESIS
    Thaddeus Golos; Fiscal Year: 2003
  8. Fetal Velocimetry & Amino Acid Transport in Pregnancy
    FREDERICK BATTAGLIA; Fiscal Year: 2007
  9. A 3D C57BL6/J MOUSE BRAIN ATLAS MAGNETIC RESONANCE MICRO
    Helene Benveniste; Fiscal Year: 2001
  10. A Primate Model of Maternal Fetal Immune Tolerance
    Thaddeus Golos; Fiscal Year: 2006

Detail Information

Publications275 found, 100 shown here

  1. ncbi Comparative developmental anatomy of the murine and human definitive placentae
    P Georgiades
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
    Placenta 23:3-19. 2002
    ..This could be of particular benefit to mouse developmental geneticists who study placental development and have an interest in the possible clinical implications of their work...
  2. ncbi Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland
    Benjamin J Apelberg
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Environ Sci Technol 41:3891-7. 2007
    ..Our findings suggest that in utero exposure to PFOS and PFOA is ubiquitous in a population of babies born in Baltimore, MD...
  3. ncbi Maternal rescue of transforming growth factor-beta 1 null mice
    J J Letterio
    Laboratory of Chemoprevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Science 264:1936-8. 1994
    ..These results suggest an important role for maternal sources of TGF-beta 1 during development and, more generally, provide evidence for maternal rescue of targeted gene disruption in the fetus...
  4. pmc Sex differences in transgenerational alterations of growth and metabolism in progeny (F2) of female offspring (F1) of rats fed a low protein diet during pregnancy and lactation
    E Zambrano
    Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Vasco de Quiroga 15, 14000, Mexico, DF Mexico
    J Physiol 566:225-36. 2005
    ....
  5. ncbi Candidate-gene association study of mothers with pre-eclampsia, and their infants, analyzing 775 SNPs in 190 genes
    Katrina A B Goddard
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    Hum Hered 63:1-16. 2007
    ..Identification of the genetic regulators of PE may have broader implications, since women with PE are at increased risk of death from cardiovascular diseases later in life...
  6. pmc Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population
    Frederica P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Environ Health Perspect 111:201-5. 2003
    ..This study provides evidence that environmental pollutants at levels currently encountered in New York City adversely affect fetal development...
  7. ncbi Fish intake during pregnancy and early cognitive development of offspring
    Julie L Daniels
    National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA juliedanielsunc edu
    Epidemiology 15:394-402. 2004
    ..Previous investigations of fish intake in relation to neurodevelopment have focused on possible damage from contaminants, whereas potential benefits of fish consumption have been relatively unexplored..
  8. ncbi Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific
    Babak Baban
    Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia 1120, 15th Street, Augusta, GA 30912 2600, USA
    J Reprod Immunol 61:67-77. 2004
    ..Hence, IDO is a key immunosuppressive mechanism in normal murine pregnancies, and it is regulated entirely through maternally inherited fetal genes...
  9. ncbi Fetal origins of breast cancer
    Leena Hilakivi-Clarke
    Georgetown University, Washington DC 20057, USA
    Trends Endocrinol Metab 17:340-8. 2006
    ..Identifying the epigenetically altered target genes and their ligands might lead to strategies to prevent this disease in some women...
  10. pmc Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny
    Rosalía Lavado-Autric
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Madrid, Spain
    J Clin Invest 111:1073-82. 2003
    ....
  11. ncbi Cubilin and megalin: partners in lipoprotein and vitamin metabolism
    J L Barth
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC 29425 2204, USA
    Trends Cardiovasc Med 11:26-31. 2001
    ..In this article, we review the state of knowledge pertaining to cubilin and megalin, emphasizing their joint roles in both lipoprotein and vitamin metabolism...
  12. ncbi Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure
    Wade V Welshons
    Department of Biomedical Sciences, E102 Veterinary Medicine, University of Missouri Columbia, Columbia, Missouri 65211 5120, USA
    Endocrinology 147:S56-69. 2006
    ....
  13. pmc Role of P-glycoprotein in transplacental transfer of methadone
    Tatiana Nanovskaya
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0587, USA
    Biochem Pharmacol 69:1869-78. 2005
    ..It is reasonable to speculate that placental disposition of methadone affects its concentration in the fetal circulation. If true, this may also be directly related to the incidence and intensity of neonatal abstinence syndrome (NAS)...
  14. ncbi Nutrition of the human fetus during the first trimester--a review
    G J Burton
    Department of Anatomy, University of Cambridge, UK
    Placenta 22:S70-7. 2001
    ..Once this is complete, and fetal oxygen requirements rise, there is a transition to haemotrophic nutrition at the start of the second trimester, when the maternal placental circulation is fully established...
  15. ncbi Levels of hexachlorobenzene and other organochlorine compounds in cord blood: exposure across placenta
    M Sala
    Environmental and Respiratory Research Unit, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Chemosphere 43:895-901. 2001
    ..Maternal p,p'DDE and beta-HCH levels were also associated with newborn levels, but levels of PCBs were not. We conclude that HCB, similar to other organochlorinated compounds, has a transplacental transfer...
  16. ncbi Polybrominated diphenyl ethers in paired samples of maternal and umbilical cord blood plasma and associations with house dust in a Danish cohort
    Marie Frederiksen
    Department of Environment and Health, Institute of Public Health, University of Copenhagen, Oester Farimagsgade 5, 1014 Copenhagen K, Denmark
    Int J Hyg Environ Health 213:233-42. 2010
    ..The positive correlations for PBDEs for both maternal and umbilical cord plasma with house dust showed that domestic house dust is a significant source of human exposure to PBDEs in Denmark including in utero exposure...
  17. pmc An assessment of the cord blood:maternal blood methylmercury ratio: implications for risk assessment
    Alan H Stern
    Division of Science, Research and Technology, New Jersey Department of Environmental Protection, PO Box 409, 401 E State Street, Trenton, NJ 08625, USA
    Environ Health Perspect 111:1465-70. 2003
    ..Whether the information generated in this analysis is sufficient to warrant a revision to the RfD will depend on the outcome of a comprehensive reanalysis of the entire one-compartment model. We are currently engaged in such an analysis...
  18. ncbi Decidual NK cells regulate key developmental processes at the human fetal-maternal interface
    Jacob Hanna
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Nat Med 12:1065-74. 2006
    ..The overall results support a 'peaceful' model for reproductive immunology, in which elements of innate immunity have been incorporated in a constructive manner to support reproductive tissue development...
  19. ncbi Leptin distribution and metabolism in the pregnant rat: transplacental leptin passage increases in late gestation but is reduced by excess glucocorticoids
    Jeremy T Smith
    School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Endocrinology 144:3024-30. 2003
    ..Consistent with the proposed role of leptin as a fetal growth factor, transplacental leptin passage is reduced in association with glucocorticoid-induced fetal growth retardation...
  20. ncbi Declining risk of methylmercury exposure to infants during lactation
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, 4058 18 Hama, Minamata, 867 0008, Kumamoto, Japan
    Environ Res 90:185-9. 2002
    ..9 times of that at birth. Thus, offspring are subjected to MeHg exposure through both the gestation and the breast-feeding periods; the risk is especially high during gestation but may decrease during breast-feeding...
  21. pmc Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface
    Craig S Clements
    Protein Crystallography Unit, Monash Centre for Synchrotron Science, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    Proc Natl Acad Sci U S A 102:3360-5. 2005
    ..The structural data suggest a head-to-tail mode of dimerization, mediated by an intermolecular disulfide bond, that is consistent with the observation of HLA-G dimers on the cell surface...
  22. pmc Maternal blood lead concentration, diet during pregnancy, and anthropometry predict neonatal blood lead in a socioeconomically disadvantaged population
    Lawrence M Schell
    Department of Epidemiology, University at Albany, State University of New York, Albany, New York, USA
    Environ Health Perspect 111:195-200. 2003
    ..Nevertheless, the influences of maternal anthropometric variables, iron, and vitamin D on neonatal lead levels are clear in our analyses...
  23. ncbi Evolutionary transformations of chorioallantoic placental characters in rodentia with special reference to hystricognath species
    Andrea Mess
    Institut für Systematische Zoologie, Museum für Naturkunde, Humboldt Universitat Berlin, Invalidenstrasse 43, 10115 Berlin, Germany
    J Exp Zool A Comp Exp Biol 299:78-98. 2003
    ..Microscopically, the interhaemal membrane is formed by the cytotrophoblast. In addition to the mentioned transformations, some aspects of other fetal membrane differentiation in Rodentia are briefly discussed...
  24. ncbi Perfluorooctanoate: Placental and lactational transport pharmacokinetics in rats
    Paul M Hinderliter
    DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, P O Box 50, Newark, DE 19714, USA
    Toxicology 211:139-48. 2005
    ..These pharmacokinetics allow estimation of the dose to developing and nursing rat offspring following maternal exposure...
  25. ncbi Immunology of normal pregnancy
    Kjersti M Aagaard-Tillery
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah Health Sciences, 30 North 1900 East, SOM 2B200, Salt Lake City, UT 84132, USA
    Semin Fetal Neonatal Med 11:279-95. 2006
    ..In this review, we summarise what is known regarding the immunology of normal pregnancy, with special emphasis on the relation to common disorders of pregnancy...
  26. ncbi Placental cell expression of HLA-G2 isoforms is limited to the invasive trophoblast phenotype
    Pedro J Morales
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Immunol 171:6215-24. 2003
    ....
  27. ncbi B7 family molecules are favorably positioned at the human maternal-fetal interface
    Margaret G Petroff
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City 66160, USA
    Biol Reprod 68:1496-504. 2003
    ..Conversely, B7-2 was absent on trophoblasts and was appropriately localized to fetal and maternal macrophages, which may participate in antigen presentation...
  28. ncbi Perinatal metabolism of dichlorodiphenyldichloroethylene in Nicaraguan mothers
    J G Dorea
    Department of Nutrition and Department of Chemistry, Universidade de Brasilia, Brasilia, 70919, Brazil
    Environ Res 86:229-37. 2001
    ..Although DDE accumulation may be less during fetal development than during breast feeding, exposure during embryogenesis may be more important than during the postnatal period...
  29. pmc Perfluorooctane sulfonate (PFOS) and related perfluorinated compounds in human maternal and cord blood samples: assessment of PFOS exposure in a susceptible population during pregnancy
    Koichi Inoue
    Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Environ Health Perspect 112:1204-7. 2004
    ..Further investigation is required to determine the postnatal effects of fetal exposure to FOCs. Key words: cord blood, fluorinated organic compounds, human, PFOA, PFOS, PFOSA, pregnancy...
  30. ncbi PCB exposure in utero and via breast milk. A review
    E P DeKoning
    Department of Epidemiology, Michigan State University, East Lansing 48823, USA
    J Expo Anal Environ Epidemiol 10:285-93. 2000
    ..In order to compare PCB concentrations in various tissues and with other studies, concentrations should be determined on a lipid basis...
  31. ncbi Non-T-cell-depleted HLA haploidentical stem cell transplantation in advanced hematologic malignancies based on the feto-maternal michrochimerism
    Chihiro Shimazaki
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan
    Blood 101:3334-6. 2003
    ..The other 3 patients survived, with one patient in complete remission. These observations suggest that haploidentical SCT based on the feto-maternal microchimerism without TCD is possible...
  32. ncbi Soluble HLA-G influences the release of cytokines from allogeneic peripheral blood mononuclear cells in culture
    T Kanai
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 Japan
    Mol Hum Reprod 7:195-200. 2001
    ..These results suggest that sHLA-G regulates the release of cytokines from PBMC chiefly by counterbalancing mHLA-G, and thereby may play a role in maintaining pregnancy...
  33. ncbi Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation
    B Huppertz
    Department of Anatomy, University Hospital RWTH Aachen, Germany
    Placenta 24:181-90. 2003
    ..Since uteroplacental ischaemia is a significant risk factor for pre-eclampsia, these findings may explain the link between reduced uteroplacental blood flow and the systemic clinical manifestations of this disease...
  34. ncbi Cytokines of the placenta and extra-placental membranes: biosynthesis, secretion and roles in establishment of pregnancy in women
    J M Bowen
    The Liggins Institute, Division of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Placenta 23:239-56. 2002
    ..Cytokines thus appear to be an important component of a paracrine/autocrine communication network operating within the feto-maternal interface to ensure the successful establishment of pregnancy...
  35. ncbi Distribution of polybrominated diphenyl ethers in human umbilical cord serum, paternal serum, maternal serum, placentas, and breast milk from Madrid population, Spain
    B Gómara
    Department of Instrumental Analysis and Environmental Chemistry, Institute of General Organic Chemistry, CSIC, Juan de la Cierva, 3, 28006 Madrid, Spain
    Environ Sci Technol 41:6961-8. 2007
    ..The presence of PBDEs in cord blood and placenta samples indicates that there is prenatal exposure of PBDEs, which could continue after birth via breast milk...
  36. ncbi Microchimerism: an investigative frontier in autoimmunity and transplantation
    Kristina M Adams
    Program in Human Immunogenetics, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    JAMA 291:1127-31. 2004
    ..Advances in this new frontier of research with varied and numerous implications for human health are summarized...
  37. ncbi Drug transfer and metabolism by the human placenta
    Michael R Syme
    Division of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Clin Pharmacokinet 43:487-514. 2004
    ..Improved knowledge regarding transplacental drug transfer and metabolism will result in further expansion of pharmacological treatment of fetal conditions...
  38. pmc Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero
    Jeff E Mold
    Division of Experimental Medicine, Department of Medicine, University of California at San Francisco UCSF, San Francisco, CA 94110, USA
    Science 322:1562-5. 2008
    ..These findings reveal a form of antigen-specific tolerance in humans, induced in utero and probably active in regulating immune responses after birth...
  39. ncbi Transplacental transfer of organochlorines in California sea lions (Zalophus californianus)
    Denise J Greig
    The Marine Mammal Center, 1065 Fort Cronkhite, Sausalito, California 94965, USA
    Environ Toxicol Chem 26:37-44. 2007
    ..Fetal TEQ was explained by maternal TEQ and maternal age. The ability to predict contaminant concentrations in fetal blubber from maternal parameters is important for developing risk assessment models for marine mammals...
  40. pmc Transport of methylmercury and inorganic mercury to the fetus and breast-fed infant
    Karolin Ask Björnberg
    Division of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Environ Health Perspect 113:1381-5. 2005
    ....
  41. ncbi Concentrations of xenobiotic chemicals in the maternal-fetal unit
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States
    Reprod Toxicol 23:260-6. 2007
    ..In some instances where known health outcomes have occurred from these exposures, we note these and any caveats associated with the exposures...
  42. ncbi Neonatal lupus syndromes
    Jill P Buyon
    Department of Medicine, New York University School of Medicine, New York, New York, USA
    Curr Opin Rheumatol 15:535-41. 2003
    ..To further efforts both at the bench and bedside, national research registries established in the United States and Canada are critical...
  43. ncbi Transfer of inflammatory cytokines across the placenta
    Michael V Zaretsky
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9032, USA
    Obstet Gynecol 103:546-50. 2004
    ..The purpose of this study was to determine whether the placental transfer of interleukin (IL)-1alpha, IL-6, and tumor necrosis factor-alpha (TNF-alpha) occurs...
  44. ncbi A functional platelet fibrinogen receptor with a deletion in the cysteine-rich repeat region of the beta(3) integrin: the Oe(a) alloantigen in neonatal alloimmune thrombocytopenia
    Sentot Santoso
    Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University Giessen, Germany
    Blood 99:1205-14. 2002
    ..It can be assumed that the Oe(a) form did arise as a result of a mutational event from an already mutated GPIIIa allele...
  45. ncbi The role of gamma/delta T cells in the feto-maternal relationship
    J Szekeres-Bartho
    Department of Medical Microbiology and Immunology, Pecs University Medical School, H 7643 Pecs, Hungary
    Semin Immunol 13:229-33. 2001
    ..Potentially cytotoxic V delta 2+ lymphocytes recognize HLA-E on the trophoblast via the CD94/NKG2A receptor, which induces an inhibitory signal, thus potentially inhibiting Th1 type cytokine production...
  46. ncbi The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans
    M Firan
    Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Int Immunol 13:993-1002. 2001
    ..FcRn therefore plays a central role in the maternofetal delivery of IgG and this has implications for the use of protein engineering to improve the properties of therapeutic antibodies...
  47. ncbi Seasonal variation of maternally derived respiratory syncytial virus antibodies and association with infant hospitalizations for respiratory syncytial virus
    Lone Graff Stensballe
    Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark
    J Pediatr 154:296-8. 2009
    ..We found a clear temporal association and suggest that RSV-neutralizing antibody level plays a role in the RSV seasonal pattern...
  48. ncbi Biochemical indexes of the B vitamins in cord serum are predicted by maternal B vitamin status
    Rima Obeid
    Department of Clinical Chemistry, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Am J Clin Nutr 82:133-9. 2005
    ..Vitamin B-12 is the major determinant of tHcy in newborns. Maternal status of folate, vitamin B-12, and vitamin B-6 during pregnancy may affect the biochemical markers of these micronutrients in newborns...
  49. pmc T cell recognition and immunity in the fetus and mother
    Cody A Koch
    Transplantation Biology Program, Mayo Clinic College of Medicine, Medical Sciences Building 2 66, 200 1st St SW, Rochester, MN 55905, USA
    Cell Immunol 248:12-7. 2007
    ..Site-specific immune suppression at the fetal-maternal interface would protect the fetus while allowing peripheral maternal immune responses to continue unabated...
  50. ncbi Role of the multidrug transporter proteins ABCB1 and ABCC2 in the diaplacental transport of talinolol in the term human placenta
    Karen May
    Department of Clinical Pharmacology, University of Greifswald, Greifswald, Germany
    Drug Metab Dispos 36:740-4. 2008
    ..In conclusion, maternofetal transfer of talinolol is restricted by a unidirectional process that is influenced by inhibitors of ABCC2...
  51. ncbi The effects of colony-stimulating factor-1 on the distribution of mononuclear phagocytes in the developing osteopetrotic mouse
    P Roth
    Division of Neonatology, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA
    Blood 91:3773-83. 1998
    ..However, because some Mphi developed in the complete absence of CSF-1, other factors must also be involved in the regulation of macrophage development...
  52. ncbi Maternal-fetal transfer of endocrine disruptors in the induction of Calbindin-D9k mRNA and protein during pregnancy in rat model
    Eui Ju Hong
    Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, 361 763 Chungbuk, South Korea
    Mol Cell Endocrinol 212:63-72. 2003
    ....
  53. ncbi Assessing maternal genetic associations: a comparison of the log-linear approach to case-parent triad data and a case-control approach
    Jacqueline R Starr
    Department of Pediatrics, Division of Genetics and Developmental Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Epidemiology 16:294-303. 2005
    ....
  54. ncbi Implications of dietary fatty acids during pregnancy on placental, fetal and postnatal development--a review
    Emilio Herrera
    Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Ctra Boadilla del Monte km 5, 300, E 28668 Boadilla del Monte Madrid, Spain
    Placenta 23:S9-19. 2002
    ..Thus, since benefit to risks of modifying maternal fat intake in pregnancy and lactation are not yet completely established, additional studies are needed before recommendations to increase LCPUFA intake in pregnancy are made...
  55. pmc Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP receptor
    C S Kovacs
    Endocrine Unit, Massachusetts General Hospital, Boston 02114, USA
    Proc Natl Acad Sci U S A 93:15233-8. 1996
    ..In addition, the bioactivity of PTHrP for placental calcium transport is specified by a mid-molecular region that does not use the PTH/PTHrP receptor...
  56. ncbi Carry-over of persistent organochlorine pesticides through placenta to fetus
    S M Waliszewski
    Instituto de Medicina Forense de la Universidad Veracruzana, Veracruz, Ver, Mexico
    Salud Publica Mex 42:384-90. 2000
    ..To establish their distribution in the human body, the concentration gradients of organochlorine pesticides between these compartments were determined...
  57. ncbi Protein expression and peptide binding suggest unique and interacting functional roles for HLA-E, F, and G in maternal-placental immune recognition
    Akiko Ishitani
    Nara Medical University, Kashihara, Nara, Japan
    J Immunol 171:1376-84. 2003
    ....
  58. ncbi Placental transport of immunoglobulin G
    Neil E Simister
    Rosenstiel Center for Basic Biomedical Sciences and Biology Department, Brandeis University, 415 South Street, Waltham, MA 02254 9110, USA
    Vaccine 21:3365-9. 2003
    ..Endothelial cells in terminal villi express FcgammaRIIb. However, it is not known whether this receptor transports IgG or prevents transport of immune complexes to the fetus...
  59. ncbi Maternal-fetal interactions and MHC polymorphism
    D Haig
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    J Reprod Immunol 35:101-9. 1997
    ..If the artificial assumption of symmetrical selection is relaxed, the second class of model (gestational drive) could account for the otherwise inexplicable absence of MHC polymorphism in some species...
  60. ncbi Phthalate monoesters in perfusate from a dual placenta perfusion system, the placenta tissue and umbilical cord blood
    Tina Mose
    Department of Occupational and Environmental Health, Institute of Public Health, University of Copenhagen, Denmark
    Reprod Toxicol 23:83-91. 2007
    ..Results from the present study of compounds residing in the tissue are essential before studying human transplacental transfer, storage, and metabolism of selected phthalate monoesters...
  61. ncbi Ex vivo human placenta models: transport of immunoglobulin G and its subclasses
    Antoine Malek
    Reproductive and Perinatal Medicine Research Laboratory, Department of Obstetrics and Gynecology, University of Berne, Inselspital, KKL G3 825, CH 3010 Bern, Switzerland
    Vaccine 21:3362-4. 2003
    ..The similarity in transfer of anti-TT-IgG and tetanus antigen, which was observed under in vivo and in vitro conditions, may suggest the transport as antibody-antigen complex...
  62. ncbi Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy
    A L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, 1120 15th St, Augusta, GA 30912, USA
    Nat Immunol 2:64-8. 2001
    ..These data show that IDO activity protects the fetus by suppressing T cell-driven local inflammatory responses to fetal alloantigens...
  63. ncbi Exposure to the estrogenic pollutant bisphenol A affects pain behavior induced by subcutaneous formalin injection in male and female rats
    Anna Maria Aloisi
    Institute of Human Physiology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    Brain Res 937:1-7. 2002
    ..These results indicate that exposure to BPA modified the activity of neural pathways and/or centers involved in nociception and pain in a sex-related and exposure-related manner...
  64. ncbi Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat
    Ilonka A T M Meerts
    Toxicology Group, Wageningen University and Research Center, Tuinlaan 5, 6703 HE Wageningen, The Netherlands
    Toxicol Sci 68:361-71. 2002
    ..Consequently, TT(4) levels in fetal plasma and brain samples were reduced. Despite reductions in fetal brain T(4) levels, the active hormone (T(3)) in fetal brains remained unaffected...
  65. ncbi Placental regulation of fatty acid delivery and its effect on fetal growth--a review
    Paul Haggarty
    Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Placenta 23:S28-38. 2002
    ....
  66. ncbi Experimental methods to study human transplacental exposure to genotoxic agents
    Kirsi Vahakangas
    Department of Pharmacology and Toxicology, University of Kuopio, P O Box 1627, FI 70211 Kuopio, Finland
    Mutat Res 608:129-35. 2006
    ..Furthermore, perfusion of placentas from mothers, who smoke, use illegal drugs or have a disease, allows studies on the impact of such factors on fetal exposure to genotoxic agents...
  67. ncbi Metabolism and pharmacokinetics of bisphenol A (BPA) and the embryo-fetal distribution of BPA and BPA-monoglucuronide in CD Sprague-Dawley rats at three gestational stages
    J Y Domoradzki
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA
    Toxicol Sci 76:21-34. 2003
    ..013 and 0.018 mug eq/g, respectively. Therefore, no selective affinity of either yolk sac/placenta or embryo/fetus for BPA or BPA metabolites relative to maternal plasma or tissues was observed in this study...
  68. ncbi Functional role of P-glycoprotein in the human blood-placental barrier
    Melissa Mölsä
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
    Clin Pharmacol Ther 78:123-31. 2005
    ..In this study we aimed to characterize the role of P-glycoprotein in the blood-placental barrier by use of dually perfused human placenta...
  69. ncbi Inhibition of 19-kDa C-terminal region of merozoite surface protein-1-specific antibody responses in neonatal pups by maternally derived 19-kDa C-terminal region of merozoite surface protein-1-specific antibodies but not whole parasite-specific antibodies
    Danielle I Stanisic
    Queensland Institute of Medical Research and CRC for Vaccine Technology, Brisbane, Australia
    J Immunol 172:5570-81. 2004
    ..If a neonate's ability to respond to MSP1(19) vaccination depends on the level of maternal Abs present at the time of vaccination, it may be necessary to delay immunization until Abs specific for the vaccinating Ag have decreased...
  70. ncbi Animal models for arsenic carcinogenesis: inorganic arsenic is a transplacental carcinogen in mice
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 198:377-84. 2004
    ..The development of these animal models should advance our understanding of the mechanisms of inorganic arsenic carcinogenesis...
  71. ncbi Maternal adaptation to high-altitude pregnancy: an experiment of nature--a review
    L G Moore
    Department of Anthropology, University of Colorado at Denver, USA
    Placenta 25:S60-71. 2004
    ..Such studies may be important for identifying persons at risk for these complications at any altitude...
  72. ncbi Transfer of proinflammatory cytokines across term placenta
    Riikka Aaltonen
    Department of Obstetrics and Gynecology and the Department of Clinical Pharmacology, Turku University Hospital, Turku, Finland
    Obstet Gynecol 106:802-7. 2005
    ....
  73. ncbi Plutonium content of human placental tissues after occupational exposure
    J J Russell
    United States Transuranium and Uranium Registries, Washington State University, Richland, WA 99352, USA
    Radiat Prot Dosimetry 104:231-6. 2003
    ..The data yielded values of 0.16 and 0.27 for placental to maternal concentrations (CPl: CM) that were of the same order of magnitude as the value of 0.1 the ICRP calculated for intakes before pregnancy...
  74. ncbi Maternal and fetal mercury and n-3 polyunsaturated fatty acids as a risk and benefit of fish consumption to fetus
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, 4058 18 Hama, Minamata, Kumamoto 867 0008, Japan
    Environ Sci Technol 38:3860-3. 2004
    ..Pregnant women in particular need not give up eating fish to obtain such benefits. However, they would do well to at least consume smaller fish, which contain less MeHg, thereby balancing the risks and benefits from fish comsumption...
  75. ncbi Implantation: embryonic signals and the modulation of the uterine environment--a review
    A T Fazleabas
    Department of Obstetrics and Gynecology, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612 7313, USA
    Placenta 25:S26-31. 2004
    ....
  76. ncbi Bidirectional transfer of methadone across human placenta
    Ilona A Nekhayeva
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0587, USA
    Biochem Pharmacol 69:187-97. 2005
    ....
  77. ncbi Insulin control of placental gene expression shifts from mother to foetus over the course of pregnancy
    U Hiden
    Clinic of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, 8036 Graz, Austria
    Diabetologia 49:123-31. 2006
    ....
  78. ncbi Enhanced urinary bladder and liver carcinogenesis in male CD1 mice exposed to transplacental inorganic arsenic and postnatal diethylstilbestrol or tamoxifen
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 215:295-305. 2006
    ..In utero arsenic also initiated urinary bladder tumor formation when followed by postnatal TAM and uroepithelial proliferative lesions when followed by TAM or DES...
  79. ncbi Transfer of maternally injected endocrine disruptors through breast milk during lactation induces neonatal Calbindin-D9k in the rat model
    Eui Ju Hong
    Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, 361 763, South Korea
    Reprod Toxicol 18:661-8. 2004
    ....
  80. pmc Polybrominated diphenyl ethers in maternal and fetal blood samples
    Anita Mazdai
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis 46202 5121, USA
    Environ Health Perspect 111:1249-52. 2003
    ..Further investigation is required to determine if these levels are specific to central Indiana and to assess the toxic potential of these exposure levels...
  81. ncbi Dose-dependent and preterm- accentuated diaplacental transport of nutritive allergens in vitro
    Monika Edelbauer
    Department of Pediatrics, University of Vienna, Austria
    Int Arch Allergy Immunol 130:25-32. 2003
    ..We investigated the role of different allergen concentrations in influencing the diaplacental allergen transport in preterm and term placentas...
  82. ncbi Maternally transmitted antibodies to pregnancy-associated variant antigens on the surface of erythrocytes infected with Plasmodium falciparum: relation to child susceptibility to malaria
    Michel Cot
    Mother and Child Health in the Tropics, Research Institute for Development, Hopital Tenon, Paris, France
    Am J Epidemiol 157:203-9. 2003
    ....
  83. pmc Estimation of health effects of prenatal methylmercury exposure using structural equation models
    Esben Budtz-Jørgensen
    Department of Biostatistics, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen, Denmark
    Environ Health 1:2. 2002
    ..This approach was used in a large epidemiological data set from a prospective study of developmental methyl-mercury toxicity...
  84. ncbi Detecting genotype combinations that increase risk for disease: maternal-fetal genotype incompatibility test
    Janet S Sinsheimer
    Department of Human Genetics, University of California, Los Angeles, California 90095 1766, USA
    Genet Epidemiol 24:1-13. 2003
    ....
  85. ncbi Fetal immune responses to Plasmodium falciparum antigens in a malaria-endemic region of Cameroon
    Simon Metenou
    Department of Biology, Georgetown University, Washington, D C 20057, USA
    J Immunol 178:2770-7. 2007
    ..Because many infants living in a low transmission area are born with malaria-specific B and T cells, the influence of in utero priming on neonatal immunity merits further investigation...
  86. ncbi Distribution of PCBs and organochlorine pesticides in umbilical cord and maternal serum
    A Covaci
    Toxicological Centre, University of Antwerp, Wilrijk, Belgium
    Sci Total Environ 298:45-53. 2002
    ..74 and 0.92, P<0.05). We conclude that all investigated organochlorine compounds have an efficient transplacental transfer...
  87. pmc Disposition of orally administered 2,2-Bis(4-hydroxyphenyl)propane (Bisphenol A) in pregnant rats and the placental transfer to fetuses
    O Takahashi
    Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Tokyo, Japan
    Environ Health Perspect 108:931-5. 2000
    ..These results suggest that the absorption and distribution of BPA in maternal organs and fetuses are extremely rapid and that the placenta does not act as a barrier to BPA...
  88. ncbi Maternal bone lead as an independent risk factor for fetal neurotoxicity: a prospective study
    Ahmed Gomaa
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Pediatrics 110:110-8. 2002
    ..Our objective was to compare lead levels in umbilical cord blood and maternal bone as independent predictors of infant mental development using a prospective design...
  89. ncbi Human endothelial cells of the placental barrier efficiently deliver cholesterol to the fetal circulation via ABCA1 and ABCG1
    Jasminka Stefulj
    Institute of Pathophysiology and Immunology, Center of Molecular Medicine, Medical University Graz, Graz, Austria
    Circ Res 104:600-8. 2009
    ..We propose a sequential pathway mediated by ABCA1 and ABCG1, respectively, by which HPECs participate in forming mature HDL in the fetal blood...
  90. ncbi Transplacentally acquired maternal T lymphocytes in severe combined immunodeficiency: a study of 121 patients
    S M Muller
    Department of Pediatrics, University of Ulm, Germany
    Blood 98:1847-51. 2001
    ..In this study, further understanding is provided of a phenomenon that is responsible for the significant heterogeneity of clinical and immunological findings in SCID...
  91. pmc Localization of pro-inflammatory (IL-12, IL-15) and anti-inflammatory (IL-11, IL-13) cytokines at the foetomaternal interface during murine pregnancy
    S Zourbas
    INSERM U131, Clamart, France
    Clin Exp Immunol 126:519-28. 2001
    ..Each of these molecules was found at the foetomaternal interface, with specific distributions and patterns of expression depending on both the cytokine itself and the stage of pregnancy. The significance of these data is discussed...
  92. ncbi Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary, and adrenal tumors in mice
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 186:7-17. 2003
    ..The development of this rodent model of inorganic arsenic carcinogenesis has important implications in defining the mechanism of action for this common environmental carcinogen...
  93. ncbi Drugs of abuse in pregnancy
    A Wright
    University Department of Obstetrics and Gynaecology, Leeds General Infirmary, Leeds, UK
    Best Pract Res Clin Obstet Gynaecol 15:987-98. 2001
    ..Where possible, evidence from trial data is included, but much of the what is quoted is descriptive from personal experience from ourselves and others working in the field...
  94. pmc Human prenatal and postnatal exposure to polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorobiphenylols, and pentachlorophenol
    Daiva Meironyté Guvenius
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Environ Health Perspect 111:1235-41. 2003
    ..Exposures to both PCBs and PBDEs, and in particular to the endocrine-active halogenated phenolic compounds, are of concern and implicate a potential risk for developmental disturbances...
  95. ncbi Breastfeeding, exposure to organochlorine compounds, and neurodevelopment in infants
    Nuria Ribas-Fito
    Environmental and Respiratory Research Unit, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Pediatrics 111:e580-5. 2003
    ..We studied the association between exposure to OCs and breastfeeding on neurodevelopment in the 1-year-old infants of this population...
  96. ncbi Transplacental transfer of schistosomal circulating anodic antigens in cows
    S Gabriel
    Department of Clinical Studies, School of Veterinary Medicine, University of Zambia, Box 32379, Lusaka, Zambia
    Parasite Immunol 24:521-5. 2002
    ..The suggested intrauterine antigenic stimulation may be important not only for generating immune responses to natural early infections, but also for enhancing the immunogenicity and efficacy of vaccines administered to newborns...
  97. ncbi Isolation from human placenta of the IgG transporter, FcRn, and localization to the syncytiotrophoblast: implications for maternal-fetal antibody transport
    J L Leach
    The Ohio State Biochemistry Program, The Ohio State University, Columbus 43210, USA
    J Immunol 157:3317-22. 1996
    ..Furthermore, the known characteristics of FcRn suggest a wider function, that it is the receptor postulated by Brambell in the 1960s to regulate tissue and serum IgG concentrations by controlling IgG transport and catabolism...
  98. ncbi Fas ligand is positioned in mouse uterus and placenta to prevent trafficking of activated leukocytes between the mother and the conceptus
    J S Hunt
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City 66160, USA
    J Immunol 158:4122-8. 1997
    ..These observations are consistent with the idea that FasL at the maternal-fetal interface protects the placenta against a maternal leukocytic influx that reduces fertility...
  99. ncbi Transplacental exposure of neonates to perfluorooctanesulfonate and perfluorooctanoate: a pilot study
    O Midasch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25, 91054, Erlangen, Germany
    Int Arch Occup Environ Health 80:643-8. 2007
    ..On the basis of the comparison of maternal and umbilical cord plasma sample pairs we wanted to examine whether infants are exposed to PFOS and PFOA via their mothers' blood...
  100. pmc Threshold of trichloroethylene contamination in maternal drinking waters affecting fetal heart development in the rat
    Paula D Johnson
    University Animal Care, University of Arizona, Tucson, Arizona, USA
    Environ Health Perspect 111:289-92. 2003
    ..e., < 250 ppb). Maternal rats exposed to more than this level of TCE during pregnancy showed an associated increased incidence of cardiac malformations in their developing rat fetuses...
  101. ncbi Correlation between blood mercury levels in mothers and newborns in Itaituba, Pará State, Brazil
    Elisabeth Oliveira Santos
    Seção de Meio Ambiente, Instituto Evandro Chagas, Ananindeua, Brasil
    Cad Saude Publica 23:S622-9. 2007
    ..8019; p = 0.000), with a significant linear regression model (r = 0.5283; p = 0.000). The results highlight the importance of monitoring pregnant women exposed to mercury as part of public health surveillance...

Research Grants65

  1. Utilizing Ethyl Nitrate Gas in Laparoscopic Surgery
    James Reynolds; Fiscal Year: 2006
    ..abstract_text> ..
  2. MOLECULAR BASIS OF PLACENTAL WATER AND SOLUTE TRANSPORT
    NICHOLAS ILLSLEY; Fiscal Year: 1993
    ....
  3. 14th International Society for Prenatal Diagnosis Meeting
    DIANA BIANCHI; Fiscal Year: 2008
    ..As a result of the conference, participants will be able to identify limitations and gaps in current practice and knowledge and develop a research agenda going forward. [unreadable] [unreadable] [unreadable]..
  4. DECIDUAL CELL/PLACENTAL INTERACTIONS
    JOAN HUNT; Fiscal Year: 2007
    ..abstract_text> ..
  5. BIOMARKERS OF GENETIC DAMAGE AND ANTIOXIDANT
    Frederica Perera; Fiscal Year: 2001
    ..Once validated in this model population, these biomarkers would also have applicability in evaluating interventions in occupational cohorts and other populations highly exposed to carcinogens. ..
  6. VULNERABILITY OF THE FETUS/INFANT TO PAH, PM2.5 AND ETS.
    Frederica Perera; Fiscal Year: 2004
    ....
  7. STRATEGIES FOR PRIMATE TRANSGENESIS
    Thaddeus Golos; Fiscal Year: 2003
    ..abstract_text> ..
  8. Fetal Velocimetry & Amino Acid Transport in Pregnancy
    FREDERICK BATTAGLIA; Fiscal Year: 2007
    ..These studies will establish important links between blood flow changes in the fetus and nutrient delivery to the fetus. ..
  9. A 3D C57BL6/J MOUSE BRAIN ATLAS MAGNETIC RESONANCE MICRO
    Helene Benveniste; Fiscal Year: 2001
    ..Further, a probabilistic (averaged from many brain specimens) atlas with error estimations will be created for registration of actual gene-expression data. ..
  10. A Primate Model of Maternal Fetal Immune Tolerance
    Thaddeus Golos; Fiscal Year: 2006
    ..The successful implementation of our recent adaptation of transgenic technology to the primate placenta will provide unprecedented opportunity for novel models of primate placental biology. ..
  11. UTERINE NK CELLS IN PRIMATE PREGNANCY
    Thaddeus G Golos; Fiscal Year: 2010
    ..for an important role of placental MHC class I molecules in the maternal immunological response to pregnancy in primates, and will further study the mechanisms and significance of these responses with two specific aims: ..
  12. Human Biology Association 2002 Annual Meeting
    LORNA MOORE; Fiscal Year: 2002
    ..abstract_text> ..
  13. A PRIMATE ES CELL MODEL FOR EMBRYO IMPLANTATION
    Thaddeus Golos; Fiscal Year: 2009
    ..abstract_text> ..
  14. A 3D C57BL6/J MOUSE BRAIN ATLAS MAGNETIC RESONANCE MICRO
    Helene Benveniste; Fiscal Year: 2003
    ..Further, a probabilistic (averaged from many brain specimens) atlas with error estimations will be created for registration of actual gene-expression data. ..
  15. ES CELL MODEL FOR PLACENTAL DEVELOPMENT
    Thaddeus Golos; Fiscal Year: 2006
    ..This proposal will allow us to develop the tools to advance a novel system for the study of primate placental biology. [unreadable] [unreadable]..
  16. Behavioral Effects of Gestational Inhalant Abuse in Rats
    Scott Bowen; Fiscal Year: 2006
    ..Finally, this research has the potential to assist in the design of effective treatments for inhalant abuse. [unreadable] [unreadable]..
  17. Mechanisms By Which Maternal And Fetal Drug Exposure Is*
    Jashvant Unadkat; Fiscal Year: 2006
    ..Once tested, we will be able to predict the magnitude of change in dose that should be instituted for a wide range of drugs whose disposition is significantly modulated by these transporters. ..
  18. Mesenchymal Stem Cells for Fetal Gene Delivery
    Alice Tarantal; Fiscal Year: 2006
    ..abstract_text> ..
  19. ALCOHOL EFFECT ON HUMAN LACTATION AND INFANT BEHAVIOR
    JULIE MENNELLA; Fiscal Year: 2007
    ..AIM 3: To explore the role of early experiences with ethanol in mothers' milk and the emotional context of such experiences, on the recognition of, and preference for, the sensory properties of ethanol ..
  20. Nutrition, Fetal Growth, and Placental Angiogenesis
    Lawrence P Reynolds; Fiscal Year: 2010
    ..abstract_text> ..
  21. Mechanism of aPL antibody-induced Pregnancy loss
    Jane E Salmon; Fiscal Year: 2010
    ..Additionally, understanding how aPL antibodies "cause" pregnancy loss may translate into new concepts about maternal-fetal tolerance and miscarriages in general and benefit women with non-APS- related pregnancy complications. ..
  22. Bipolar Disorder in Pregnancy: Predictors of Morbidity
    DONALD NEWPORT; Fiscal Year: 2009
    ..Furthermore, the novel PK data will expand our understanding of prenatal drug metabolism, and the project will establish a cohort of children of women with BPD with detailed prospective prenatal histories. ..
  23. NUTRITIONAL COPPER STATUS AND THE NERVOUS SYSTEM
    JOSEPH ROBERT PROHASKA; Fiscal Year: 2010
    ..AIM 4: We will test the hypothesis that limitation in Cu-dependent ferroxidases lead to lower brain iron and are responsible by comparing rats reared on an iron-fortified diet to restore brain iron. ..
  24. Center for Pediatric Stem/Progenitor Cell Translational Research
    Alice Tarantal; Fiscal Year: 2008
    ..If imaging techniques can be developed that allows one to monitor the cells over time, this would provide a very powerful tool to determine the fate of the cells after injection into humans. ..
  25. Nucleoside Transporters: disposition of nucleoside drugs
    Jashvant Unadkat; Fiscal Year: 2008
    ..abstract_text> ..
  26. Maternal Influence in the Development of Asthma
    Edward Barrett; Fiscal Year: 2008
    ..This application will provide new insight into the underlying mechanisms that contribute to the development of asthma and identify new targets for preventative therapies. ..
  27. Complement as a Mediator of Recurrent Miscarriages
    Jane Salmon; Fiscal Year: 2008
    ..In addition, our studies will provide insights into mechanisms by which complement-induces disease and suggest means to prevent, arrest, or modify complement-mediated inflammatory disorders. [unreadable] [unreadable]..
  28. IMMUNE PROTECTION AGAINST MNU-INDUCTED DIGITAL DEFECTS
    MARY PRATER; Fiscal Year: 2006
    ..This research under the guidance of Drs. Steven Holladay and Eric Wong at Virginia Tech...
  29. Fetal Determinants of Atherosclerosis
    Wulf Palinski; Fiscal Year: 2006
    ..These studies should yield fundamentally new insights into in utero programming and atherogenic mechanisms, and may establish a novel preventive approach. ..
  30. INTRAUTERINE ASPHYXIAL ENCEPHALOPATHY
    Peter Gluckman; Fiscal Year: 2001
    ..By further elucidating the pathogenesis of prenatal and perinatal asphyxial encephalopathy these studies will provide important information towards improving perinatal diagnosis, monitoring and intervention. ..
  31. Targets for New Therapeutics for SLE
    Jane Salmon; Fiscal Year: 2002
    ..abstract_text> ..
  32. ETHANOL, RETINOIDS, AND CONGENITAL HEART MALFORMATIONS
    Janee Gelineau van Waes; Fiscal Year: 2003
    ..abstract_text> ..
  33. Validation of biomarkers of prenatal pesticides exposure
    Robin Whyatt; Fiscal Year: 2003
    ....
  34. Enhance Effectiveness of Anti-HIV Drugs in the CNS
    Jashvant Unadkat; Fiscal Year: 2003
    ..To test our hypothesis, using PET, that inhibition of P-gp in creases the exposure of CNS to l"1CJ-verapamil and, by inference, protease inhibitors. ..
  35. Cognitive dysfunction in neuropsychiatric-SLE
    Michael Lockshin; Fiscal Year: 2002
    ..Successful completion of this research will redefine the pathogenesis of cognitive dysfunction and suggest therapeutic targets for intervention...
  36. THE MAJOR ANGIOGENIC FACTORS IN PLACENTAL ANGIOGENESIS
    Lawrence Reynolds; Fiscal Year: 2004
    ..abstract_text> ..
  37. Self-administration of abused inhalants in mice
    Scott Bowen; Fiscal Year: 2004
    ....
  38. A Preclinical Model of Adolescent Toluene Abuse in Rats
    Scott Bowen; Fiscal Year: 2005
    ..The model also has the potential to assist in devising effective treatments and prevention strategies for adolescent inhalant abuse. ..
  39. Center for Fetal Gene Transfer for HLB Diseases
    Alice Tarantal; Fiscal Year: 2005
    ..abstract_text> ..
  40. Prenatal Insecticide Exposures Among Urban Minorities
    Robin Whyatt; Fiscal Year: 2005
    ..The research will provide important information about pesticide exposure during pregnancy among this minority cohort. ..
  41. Development Psychopharmacology
    DONALD NEWPORT; Fiscal Year: 2005
    ..These study procedures will furthermore be applicable to future research investigating other classes of psychotropic medications. ..
  42. Mechanism for maternal transfer of asthma risk
    Robert Lim; Fiscal Year: 2007
    ..Third, dendritic cell gene expression patterns between these two groups will be compared using gene arrays ..
  43. Adapting CHAMP+ for South Africa: Supporting HIV-Infected Youth and Families
    Claude Mellins; Fiscal Year: 2008
    ..The findings can be used to inform larger-scale effectiveness studies in similar settings. [unreadable] [unreadable] [unreadable]..
  44. OXIDATIVE STRESS, ANTIOXIDANT STATUS & PREGNANCY OUTCOME
    Theresa Scholl; Fiscal Year: 2005
    ....
  45. Molecular mechanism of ADNF and ADNP peptides in neuroprotection to alcohol
    Youssef Sari; Fiscal Year: 2008
    ..This data will shed light on the mechanisms governing brain ontogeny and will pave the path toward potential therapeutics against developmental insults associated with prenatal alcohol exposure. [unreadable] [unreadable] [unreadable]..
  46. Fas/FasL System In Normal Mammary Gland Development
    Gil Mor; Fiscal Year: 2003
    ..With an improved foundation of the normal mammary physiology, we can advance the understanding of breast cancer, allowing the development of effective strategies for its treatment and prevention. ..
  47. Acquisition of a Confocal/Multiphoton Microscopy System
    Robert Burghardt; Fiscal Year: 2006
    ..This new technology will provide faculty, postdoctoral fellows and students with access to a state-of-the-art imaging facility and will facilitate the ongoing research of the major and minor users. [unreadable] [unreadable] [unreadable]..
  48. CONSTRUCTION OF RESEARCH ANIMAL FACILITY
    Donald Wilson; Fiscal Year: 2002
    ..The proposed project, which will be co-financed by contributions from the State of Maryland, therefore, considered instrumental for sustaining the stature of the MPRC in schizophrenia research. ..
  49. Improving primary care to prevent childhood obesity
    Matthew Gillman; Fiscal Year: 2009
    ....
  50. Prenatal factors and risk of autism in a Finnish national birth cohort
    ALAN STEWART BROWN; Fiscal Year: 2010
    ....
  51. Immune Tolerance; Sigma Receptor as a Therapeutic Target
    Vadivel Ganapathy; Fiscal Year: 2003
    ....
  52. SHORT-TERM RESEARCH TRAINING FOR MINORITY STUDENTS
    Charles Wood; Fiscal Year: 2008
    ..The emphasis of this training program in the next five years will be to significantly expand the students' horizons and to recruit students into basic biomedical science. ..
  53. Neurohormonal Effects of Massage Therapy
    Tiffany Field; Fiscal Year: 2007
    ..The K05 would allow me to increase my research time including being mentored and mentoring students from 25 to 75% time. [unreadable] [unreadable] [unreadable]..
  54. Paraxanthine and Reproductive Effects of Caffeine
    Michael Bracken; Fiscal Year: 2004
    ..abstract_text> ..
  55. Diet Impacts Nutrient Transfer to Subsequent Generations
    Donald Novak; Fiscal Year: 2004
    ..abstract_text> ..
  56. MECHANISMS IN THE REGULATION OF SP-A GENE EXPRESSION
    CAROLE MENDELSON; Fiscal Year: 2007
    ..unreadable]..
  57. Aberrant Ovine Pancreatic Development in IUGR Fetuses
    Sean Limesand; Fiscal Year: 2007
    ....
  58. Adaptation to long chain fatty acid oxidation deficiency
    Arnold Strauss; Fiscal Year: 2007
    ..We will investigate its role by generating a HERS knockout in the last specific aim. ..
  59. Fetal and Neonatal Hemodynamics in IUGR Pregnancies
    Henry Galan; Fiscal Year: 2006
    ..abstract_text> ..
  60. Methodological Research on Substance Use
    Heping Zhang; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  61. Placenta: Ethanol and HIV
    Richard Miller; Fiscal Year: 2004
    ..The experiments proposed will provide the first evidence on whether ethanol plays a role in direct transmission of the HIV virus to the fetus. ..
  62. DEVELOPMENT OF A HUMAN PLACENTA VILLOUS MICROPERFUSION
    NICHOLAS ILLSLEY; Fiscal Year: 2002
    ..This model will provide the basis for new investigations in placental transport, metabolism, and signaling and structural biology. ..
  63. Placenta Association of the Americas Conference Grant
    NICHOLAS ILLSLEY; Fiscal Year: 2007
    ..Additional support is being sought from foundations and private corporations. ..
  64. Exploration of ETS Effects on Child Behavior and Sleep
    Kimberly Yolton; Fiscal Year: 2005
    ..abstract_text> ..