Genomes and Genes
maternal fetal exchange
Summary: Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission.
Publications275 found, 100 shown here
- Comparative developmental anatomy of the murine and human definitive placentaeP Georgiades
Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
Placenta 23:3-19. 2002..This could be of particular benefit to mouse developmental geneticists who study placental development and have an interest in the possible clinical implications of their work...
- Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, MarylandBenjamin J Apelberg
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Environ Sci Technol 41:3891-7. 2007..Our findings suggest that in utero exposure to PFOS and PFOA is ubiquitous in a population of babies born in Baltimore, MD...
- Maternal rescue of transforming growth factor-beta 1 null miceJ J Letterio
Laboratory of Chemoprevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
Science 264:1936-8. 1994..These results suggest an important role for maternal sources of TGF-beta 1 during development and, more generally, provide evidence for maternal rescue of targeted gene disruption in the fetus...
- Sex differences in transgenerational alterations of growth and metabolism in progeny (F2) of female offspring (F1) of rats fed a low protein diet during pregnancy and lactationE Zambrano
Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Vasco de Quiroga 15, 14000, Mexico, DF Mexico
J Physiol 566:225-36. 2005....
- Candidate-gene association study of mothers with pre-eclampsia, and their infants, analyzing 775 SNPs in 190 genesKatrina A B Goddard
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
Hum Hered 63:1-16. 2007..Identification of the genetic regulators of PE may have broader implications, since women with PE are at increased risk of death from cardiovascular diseases later in life...
- Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic populationFrederica P Perera
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Environ Health Perspect 111:201-5. 2003..This study provides evidence that environmental pollutants at levels currently encountered in New York City adversely affect fetal development...
- Fish intake during pregnancy and early cognitive development of offspringJulie L Daniels
National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA juliedanielsunc edu
Epidemiology 15:394-402. 2004..Previous investigations of fish intake in relation to neurodevelopment have focused on possible damage from contaminants, whereas potential benefits of fish consumption have been relatively unexplored..
- Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specificBabak Baban
Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia 1120, 15th Street, Augusta, GA 30912 2600, USA
J Reprod Immunol 61:67-77. 2004..Hence, IDO is a key immunosuppressive mechanism in normal murine pregnancies, and it is regulated entirely through maternally inherited fetal genes...
- Fetal origins of breast cancerLeena Hilakivi-Clarke
Georgetown University, Washington DC 20057, USA
Trends Endocrinol Metab 17:340-8. 2006..Identifying the epigenetically altered target genes and their ligands might lead to strategies to prevent this disease in some women...
- Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progenyRosalía Lavado-Autric
Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Madrid, Spain
J Clin Invest 111:1073-82. 2003....
- Cubilin and megalin: partners in lipoprotein and vitamin metabolismJ L Barth
Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC 29425 2204, USA
Trends Cardiovasc Med 11:26-31. 2001..In this article, we review the state of knowledge pertaining to cubilin and megalin, emphasizing their joint roles in both lipoprotein and vitamin metabolism...
- Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposureWade V Welshons
Department of Biomedical Sciences, E102 Veterinary Medicine, University of Missouri Columbia, Columbia, Missouri 65211 5120, USA
Endocrinology 147:S56-69. 2006....
- Role of P-glycoprotein in transplacental transfer of methadoneTatiana Nanovskaya
Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0587, USA
Biochem Pharmacol 69:1869-78. 2005..It is reasonable to speculate that placental disposition of methadone affects its concentration in the fetal circulation. If true, this may also be directly related to the incidence and intensity of neonatal abstinence syndrome (NAS)...
- Nutrition of the human fetus during the first trimester--a reviewG J Burton
Department of Anatomy, University of Cambridge, UK
Placenta 22:S70-7. 2001..Once this is complete, and fetal oxygen requirements rise, there is a transition to haemotrophic nutrition at the start of the second trimester, when the maternal placental circulation is fully established...
- Levels of hexachlorobenzene and other organochlorine compounds in cord blood: exposure across placentaM Sala
Environmental and Respiratory Research Unit, Institut Municipal d Investigacio Medica, Barcelona, Spain
Chemosphere 43:895-901. 2001..Maternal p,p'DDE and beta-HCH levels were also associated with newborn levels, but levels of PCBs were not. We conclude that HCB, similar to other organochlorinated compounds, has a transplacental transfer...
- Polybrominated diphenyl ethers in paired samples of maternal and umbilical cord blood plasma and associations with house dust in a Danish cohortMarie Frederiksen
Department of Environment and Health, Institute of Public Health, University of Copenhagen, Oester Farimagsgade 5, 1014 Copenhagen K, Denmark
Int J Hyg Environ Health 213:233-42. 2010..The positive correlations for PBDEs for both maternal and umbilical cord plasma with house dust showed that domestic house dust is a significant source of human exposure to PBDEs in Denmark including in utero exposure...
- An assessment of the cord blood:maternal blood methylmercury ratio: implications for risk assessmentAlan H Stern
Division of Science, Research and Technology, New Jersey Department of Environmental Protection, PO Box 409, 401 E State Street, Trenton, NJ 08625, USA
Environ Health Perspect 111:1465-70. 2003..Whether the information generated in this analysis is sufficient to warrant a revision to the RfD will depend on the outcome of a comprehensive reanalysis of the entire one-compartment model. We are currently engaged in such an analysis...
- Decidual NK cells regulate key developmental processes at the human fetal-maternal interfaceJacob Hanna
The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
Nat Med 12:1065-74. 2006..The overall results support a 'peaceful' model for reproductive immunology, in which elements of innate immunity have been incorporated in a constructive manner to support reproductive tissue development...
- Leptin distribution and metabolism in the pregnant rat: transplacental leptin passage increases in late gestation but is reduced by excess glucocorticoidsJeremy T Smith
School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
Endocrinology 144:3024-30. 2003..Consistent with the proposed role of leptin as a fetal growth factor, transplacental leptin passage is reduced in association with glucocorticoid-induced fetal growth retardation...
- Declining risk of methylmercury exposure to infants during lactationMineshi Sakamoto
Department of Epidemiology, National Institute for Minamata Disease, 4058 18 Hama, Minamata, 867 0008, Kumamoto, Japan
Environ Res 90:185-9. 2002..9 times of that at birth. Thus, offspring are subjected to MeHg exposure through both the gestation and the breast-feeding periods; the risk is especially high during gestation but may decrease during breast-feeding...
- Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interfaceCraig S Clements
Protein Crystallography Unit, Monash Centre for Synchrotron Science, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
Proc Natl Acad Sci U S A 102:3360-5. 2005..The structural data suggest a head-to-tail mode of dimerization, mediated by an intermolecular disulfide bond, that is consistent with the observation of HLA-G dimers on the cell surface...
- Maternal blood lead concentration, diet during pregnancy, and anthropometry predict neonatal blood lead in a socioeconomically disadvantaged populationLawrence M Schell
Department of Epidemiology, University at Albany, State University of New York, Albany, New York, USA
Environ Health Perspect 111:195-200. 2003..Nevertheless, the influences of maternal anthropometric variables, iron, and vitamin D on neonatal lead levels are clear in our analyses...
- Evolutionary transformations of chorioallantoic placental characters in rodentia with special reference to hystricognath speciesAndrea Mess
Institut für Systematische Zoologie, Museum für Naturkunde, Humboldt Universitat Berlin, Invalidenstrasse 43, 10115 Berlin, Germany
J Exp Zool A Comp Exp Biol 299:78-98. 2003..Microscopically, the interhaemal membrane is formed by the cytotrophoblast. In addition to the mentioned transformations, some aspects of other fetal membrane differentiation in Rodentia are briefly discussed...
- Perfluorooctanoate: Placental and lactational transport pharmacokinetics in ratsPaul M Hinderliter
DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, P O Box 50, Newark, DE 19714, USA
Toxicology 211:139-48. 2005..These pharmacokinetics allow estimation of the dose to developing and nursing rat offspring following maternal exposure...
- Immunology of normal pregnancyKjersti M Aagaard-Tillery
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah Health Sciences, 30 North 1900 East, SOM 2B200, Salt Lake City, UT 84132, USA
Semin Fetal Neonatal Med 11:279-95. 2006..In this review, we summarise what is known regarding the immunology of normal pregnancy, with special emphasis on the relation to common disorders of pregnancy...
- Placental cell expression of HLA-G2 isoforms is limited to the invasive trophoblast phenotypePedro J Morales
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
J Immunol 171:6215-24. 2003....
- B7 family molecules are favorably positioned at the human maternal-fetal interfaceMargaret G Petroff
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City 66160, USA
Biol Reprod 68:1496-504. 2003..Conversely, B7-2 was absent on trophoblasts and was appropriately localized to fetal and maternal macrophages, which may participate in antigen presentation...
- Perinatal metabolism of dichlorodiphenyldichloroethylene in Nicaraguan mothersJ G Dorea
Department of Nutrition and Department of Chemistry, Universidade de Brasilia, Brasilia, 70919, Brazil
Environ Res 86:229-37. 2001..Although DDE accumulation may be less during fetal development than during breast feeding, exposure during embryogenesis may be more important than during the postnatal period...
- Perfluorooctane sulfonate (PFOS) and related perfluorinated compounds in human maternal and cord blood samples: assessment of PFOS exposure in a susceptible population during pregnancyKoichi Inoue
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
Environ Health Perspect 112:1204-7. 2004..Further investigation is required to determine the postnatal effects of fetal exposure to FOCs. Key words: cord blood, fluorinated organic compounds, human, PFOA, PFOS, PFOSA, pregnancy...
- PCB exposure in utero and via breast milk. A reviewE P DeKoning
Department of Epidemiology, Michigan State University, East Lansing 48823, USA
J Expo Anal Environ Epidemiol 10:285-93. 2000..In order to compare PCB concentrations in various tissues and with other studies, concentrations should be determined on a lipid basis...
- Non-T-cell-depleted HLA haploidentical stem cell transplantation in advanced hematologic malignancies based on the feto-maternal michrochimerismChihiro Shimazaki
Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan
Blood 101:3334-6. 2003..The other 3 patients survived, with one patient in complete remission. These observations suggest that haploidentical SCT based on the feto-maternal microchimerism without TCD is possible...
- Soluble HLA-G influences the release of cytokines from allogeneic peripheral blood mononuclear cells in cultureT Kanai
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 Japan
Mol Hum Reprod 7:195-200. 2001..These results suggest that sHLA-G regulates the release of cytokines from PBMC chiefly by counterbalancing mHLA-G, and thereby may play a role in maintaining pregnancy...
- Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulationB Huppertz
Department of Anatomy, University Hospital RWTH Aachen, Germany
Placenta 24:181-90. 2003..Since uteroplacental ischaemia is a significant risk factor for pre-eclampsia, these findings may explain the link between reduced uteroplacental blood flow and the systemic clinical manifestations of this disease...
- Cytokines of the placenta and extra-placental membranes: biosynthesis, secretion and roles in establishment of pregnancy in womenJ M Bowen
The Liggins Institute, Division of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
Placenta 23:239-56. 2002..Cytokines thus appear to be an important component of a paracrine/autocrine communication network operating within the feto-maternal interface to ensure the successful establishment of pregnancy...
- Distribution of polybrominated diphenyl ethers in human umbilical cord serum, paternal serum, maternal serum, placentas, and breast milk from Madrid population, SpainB Gómara
Department of Instrumental Analysis and Environmental Chemistry, Institute of General Organic Chemistry, CSIC, Juan de la Cierva, 3, 28006 Madrid, Spain
Environ Sci Technol 41:6961-8. 2007..The presence of PBDEs in cord blood and placenta samples indicates that there is prenatal exposure of PBDEs, which could continue after birth via breast milk...
- Microchimerism: an investigative frontier in autoimmunity and transplantationKristina M Adams
Program in Human Immunogenetics, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
JAMA 291:1127-31. 2004..Advances in this new frontier of research with varied and numerous implications for human health are summarized...
- Drug transfer and metabolism by the human placentaMichael R Syme
Division of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
Clin Pharmacokinet 43:487-514. 2004..Improved knowledge regarding transplacental drug transfer and metabolism will result in further expansion of pharmacological treatment of fetal conditions...
- Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in uteroJeff E Mold
Division of Experimental Medicine, Department of Medicine, University of California at San Francisco UCSF, San Francisco, CA 94110, USA
Science 322:1562-5. 2008..These findings reveal a form of antigen-specific tolerance in humans, induced in utero and probably active in regulating immune responses after birth...
- Transplacental transfer of organochlorines in California sea lions (Zalophus californianus)Denise J Greig
The Marine Mammal Center, 1065 Fort Cronkhite, Sausalito, California 94965, USA
Environ Toxicol Chem 26:37-44. 2007..Fetal TEQ was explained by maternal TEQ and maternal age. The ability to predict contaminant concentrations in fetal blubber from maternal parameters is important for developing risk assessment models for marine mammals...
- Transport of methylmercury and inorganic mercury to the fetus and breast-fed infantKarolin Ask Björnberg
Division of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Environ Health Perspect 113:1381-5. 2005....
- Concentrations of xenobiotic chemicals in the maternal-fetal unitDana B Barr
National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States
Reprod Toxicol 23:260-6. 2007..In some instances where known health outcomes have occurred from these exposures, we note these and any caveats associated with the exposures...
- Neonatal lupus syndromesJill P Buyon
Department of Medicine, New York University School of Medicine, New York, New York, USA
Curr Opin Rheumatol 15:535-41. 2003..To further efforts both at the bench and bedside, national research registries established in the United States and Canada are critical...
- Transfer of inflammatory cytokines across the placentaMichael V Zaretsky
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9032, USA
Obstet Gynecol 103:546-50. 2004..The purpose of this study was to determine whether the placental transfer of interleukin (IL)-1alpha, IL-6, and tumor necrosis factor-alpha (TNF-alpha) occurs...
- A functional platelet fibrinogen receptor with a deletion in the cysteine-rich repeat region of the beta(3) integrin: the Oe(a) alloantigen in neonatal alloimmune thrombocytopeniaSentot Santoso
Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University Giessen, Germany
Blood 99:1205-14. 2002..It can be assumed that the Oe(a) form did arise as a result of a mutational event from an already mutated GPIIIa allele...
- The role of gamma/delta T cells in the feto-maternal relationshipJ Szekeres-Bartho
Department of Medical Microbiology and Immunology, Pecs University Medical School, H 7643 Pecs, Hungary
Semin Immunol 13:229-33. 2001..Potentially cytotoxic V delta 2+ lymphocytes recognize HLA-E on the trophoblast via the CD94/NKG2A receptor, which induces an inhibitory signal, thus potentially inhibiting Th1 type cytokine production...
- The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humansM Firan
Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Int Immunol 13:993-1002. 2001..FcRn therefore plays a central role in the maternofetal delivery of IgG and this has implications for the use of protein engineering to improve the properties of therapeutic antibodies...
- Seasonal variation of maternally derived respiratory syncytial virus antibodies and association with infant hospitalizations for respiratory syncytial virusLone Graff Stensballe
Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark
J Pediatr 154:296-8. 2009..We found a clear temporal association and suggest that RSV-neutralizing antibody level plays a role in the RSV seasonal pattern...
- Biochemical indexes of the B vitamins in cord serum are predicted by maternal B vitamin statusRima Obeid
Department of Clinical Chemistry, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
Am J Clin Nutr 82:133-9. 2005..Vitamin B-12 is the major determinant of tHcy in newborns. Maternal status of folate, vitamin B-12, and vitamin B-6 during pregnancy may affect the biochemical markers of these micronutrients in newborns...
- T cell recognition and immunity in the fetus and motherCody A Koch
Transplantation Biology Program, Mayo Clinic College of Medicine, Medical Sciences Building 2 66, 200 1st St SW, Rochester, MN 55905, USA
Cell Immunol 248:12-7. 2007..Site-specific immune suppression at the fetal-maternal interface would protect the fetus while allowing peripheral maternal immune responses to continue unabated...
- Role of the multidrug transporter proteins ABCB1 and ABCC2 in the diaplacental transport of talinolol in the term human placentaKaren May
Department of Clinical Pharmacology, University of Greifswald, Greifswald, Germany
Drug Metab Dispos 36:740-4. 2008..In conclusion, maternofetal transfer of talinolol is restricted by a unidirectional process that is influenced by inhibitors of ABCC2...
- The effects of colony-stimulating factor-1 on the distribution of mononuclear phagocytes in the developing osteopetrotic mouseP Roth
Division of Neonatology, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA
Blood 91:3773-83. 1998..However, because some Mphi developed in the complete absence of CSF-1, other factors must also be involved in the regulation of macrophage development...
- Maternal-fetal transfer of endocrine disruptors in the induction of Calbindin-D9k mRNA and protein during pregnancy in rat modelEui Ju Hong
Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, 361 763 Chungbuk, South Korea
Mol Cell Endocrinol 212:63-72. 2003....
- Assessing maternal genetic associations: a comparison of the log-linear approach to case-parent triad data and a case-control approachJacqueline R Starr
Department of Pediatrics, Division of Genetics and Developmental Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Epidemiology 16:294-303. 2005....
- Implications of dietary fatty acids during pregnancy on placental, fetal and postnatal development--a reviewEmilio Herrera
Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Ctra Boadilla del Monte km 5, 300, E 28668 Boadilla del Monte Madrid, Spain
Placenta 23:S9-19. 2002..Thus, since benefit to risks of modifying maternal fat intake in pregnancy and lactation are not yet completely established, additional studies are needed before recommendations to increase LCPUFA intake in pregnancy are made...
- Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP receptorC S Kovacs
Endocrine Unit, Massachusetts General Hospital, Boston 02114, USA
Proc Natl Acad Sci U S A 93:15233-8. 1996..In addition, the bioactivity of PTHrP for placental calcium transport is specified by a mid-molecular region that does not use the PTH/PTHrP receptor...
- Carry-over of persistent organochlorine pesticides through placenta to fetusS M Waliszewski
Instituto de Medicina Forense de la Universidad Veracruzana, Veracruz, Ver, Mexico
Salud Publica Mex 42:384-90. 2000..To establish their distribution in the human body, the concentration gradients of organochlorine pesticides between these compartments were determined...
- Protein expression and peptide binding suggest unique and interacting functional roles for HLA-E, F, and G in maternal-placental immune recognitionAkiko Ishitani
Nara Medical University, Kashihara, Nara, Japan
J Immunol 171:1376-84. 2003....
- Placental transport of immunoglobulin GNeil E Simister
Rosenstiel Center for Basic Biomedical Sciences and Biology Department, Brandeis University, 415 South Street, Waltham, MA 02254 9110, USA
Vaccine 21:3365-9. 2003..Endothelial cells in terminal villi express FcgammaRIIb. However, it is not known whether this receptor transports IgG or prevents transport of immune complexes to the fetus...
- Maternal-fetal interactions and MHC polymorphismD Haig
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
J Reprod Immunol 35:101-9. 1997..If the artificial assumption of symmetrical selection is relaxed, the second class of model (gestational drive) could account for the otherwise inexplicable absence of MHC polymorphism in some species...
- Phthalate monoesters in perfusate from a dual placenta perfusion system, the placenta tissue and umbilical cord bloodTina Mose
Department of Occupational and Environmental Health, Institute of Public Health, University of Copenhagen, Denmark
Reprod Toxicol 23:83-91. 2007..Results from the present study of compounds residing in the tissue are essential before studying human transplacental transfer, storage, and metabolism of selected phthalate monoesters...
- Ex vivo human placenta models: transport of immunoglobulin G and its subclassesAntoine Malek
Reproductive and Perinatal Medicine Research Laboratory, Department of Obstetrics and Gynecology, University of Berne, Inselspital, KKL G3 825, CH 3010 Bern, Switzerland
Vaccine 21:3362-4. 2003..The similarity in transfer of anti-TT-IgG and tetanus antigen, which was observed under in vivo and in vitro conditions, may suggest the transport as antibody-antigen complex...
- Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancyA L Mellor
Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, 1120 15th St, Augusta, GA 30912, USA
Nat Immunol 2:64-8. 2001..These data show that IDO activity protects the fetus by suppressing T cell-driven local inflammatory responses to fetal alloantigens...
- Exposure to the estrogenic pollutant bisphenol A affects pain behavior induced by subcutaneous formalin injection in male and female ratsAnna Maria Aloisi
Institute of Human Physiology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
Brain Res 937:1-7. 2002..These results indicate that exposure to BPA modified the activity of neural pathways and/or centers involved in nociception and pain in a sex-related and exposure-related manner...
- Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the ratIlonka A T M Meerts
Toxicology Group, Wageningen University and Research Center, Tuinlaan 5, 6703 HE Wageningen, The Netherlands
Toxicol Sci 68:361-71. 2002..Consequently, TT(4) levels in fetal plasma and brain samples were reduced. Despite reductions in fetal brain T(4) levels, the active hormone (T(3)) in fetal brains remained unaffected...
- Placental regulation of fatty acid delivery and its effect on fetal growth--a reviewPaul Haggarty
Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Placenta 23:S28-38. 2002....
- Experimental methods to study human transplacental exposure to genotoxic agentsKirsi Vahakangas
Department of Pharmacology and Toxicology, University of Kuopio, P O Box 1627, FI 70211 Kuopio, Finland
Mutat Res 608:129-35. 2006..Furthermore, perfusion of placentas from mothers, who smoke, use illegal drugs or have a disease, allows studies on the impact of such factors on fetal exposure to genotoxic agents...
- Metabolism and pharmacokinetics of bisphenol A (BPA) and the embryo-fetal distribution of BPA and BPA-monoglucuronide in CD Sprague-Dawley rats at three gestational stagesJ Y Domoradzki
Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA
Toxicol Sci 76:21-34. 2003..013 and 0.018 mug eq/g, respectively. Therefore, no selective affinity of either yolk sac/placenta or embryo/fetus for BPA or BPA metabolites relative to maternal plasma or tissues was observed in this study...
- Functional role of P-glycoprotein in the human blood-placental barrierMelissa Mölsä
Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland
Clin Pharmacol Ther 78:123-31. 2005..In this study we aimed to characterize the role of P-glycoprotein in the blood-placental barrier by use of dually perfused human placenta...
- Inhibition of 19-kDa C-terminal region of merozoite surface protein-1-specific antibody responses in neonatal pups by maternally derived 19-kDa C-terminal region of merozoite surface protein-1-specific antibodies but not whole parasite-specific antibodiesDanielle I Stanisic
Queensland Institute of Medical Research and CRC for Vaccine Technology, Brisbane, Australia
J Immunol 172:5570-81. 2004..If a neonate's ability to respond to MSP1(19) vaccination depends on the level of maternal Abs present at the time of vaccination, it may be necessary to delay immunization until Abs specific for the vaccinating Ag have decreased...
- Animal models for arsenic carcinogenesis: inorganic arsenic is a transplacental carcinogen in miceMichael P Waalkes
Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 198:377-84. 2004..The development of these animal models should advance our understanding of the mechanisms of inorganic arsenic carcinogenesis...
- Maternal adaptation to high-altitude pregnancy: an experiment of nature--a reviewL G Moore
Department of Anthropology, University of Colorado at Denver, USA
Placenta 25:S60-71. 2004..Such studies may be important for identifying persons at risk for these complications at any altitude...
- Transfer of proinflammatory cytokines across term placentaRiikka Aaltonen
Department of Obstetrics and Gynecology and the Department of Clinical Pharmacology, Turku University Hospital, Turku, Finland
Obstet Gynecol 106:802-7. 2005....
- Plutonium content of human placental tissues after occupational exposureJ J Russell
United States Transuranium and Uranium Registries, Washington State University, Richland, WA 99352, USA
Radiat Prot Dosimetry 104:231-6. 2003..The data yielded values of 0.16 and 0.27 for placental to maternal concentrations (CPl: CM) that were of the same order of magnitude as the value of 0.1 the ICRP calculated for intakes before pregnancy...
- Maternal and fetal mercury and n-3 polyunsaturated fatty acids as a risk and benefit of fish consumption to fetusMineshi Sakamoto
Department of Epidemiology, National Institute for Minamata Disease, 4058 18 Hama, Minamata, Kumamoto 867 0008, Japan
Environ Sci Technol 38:3860-3. 2004..Pregnant women in particular need not give up eating fish to obtain such benefits. However, they would do well to at least consume smaller fish, which contain less MeHg, thereby balancing the risks and benefits from fish comsumption...
- Implantation: embryonic signals and the modulation of the uterine environment--a reviewA T Fazleabas
Department of Obstetrics and Gynecology, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612 7313, USA
Placenta 25:S26-31. 2004....
- Bidirectional transfer of methadone across human placentaIlona A Nekhayeva
Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0587, USA
Biochem Pharmacol 69:187-97. 2005....
- Insulin control of placental gene expression shifts from mother to foetus over the course of pregnancyU Hiden
Clinic of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, 8036 Graz, Austria
Diabetologia 49:123-31. 2006....
- Enhanced urinary bladder and liver carcinogenesis in male CD1 mice exposed to transplacental inorganic arsenic and postnatal diethylstilbestrol or tamoxifenMichael P Waalkes
Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 215:295-305. 2006..In utero arsenic also initiated urinary bladder tumor formation when followed by postnatal TAM and uroepithelial proliferative lesions when followed by TAM or DES...
- Transfer of maternally injected endocrine disruptors through breast milk during lactation induces neonatal Calbindin-D9k in the rat modelEui Ju Hong
Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, 361 763, South Korea
Reprod Toxicol 18:661-8. 2004....
- Polybrominated diphenyl ethers in maternal and fetal blood samplesAnita Mazdai
Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis 46202 5121, USA
Environ Health Perspect 111:1249-52. 2003..Further investigation is required to determine if these levels are specific to central Indiana and to assess the toxic potential of these exposure levels...
- Dose-dependent and preterm- accentuated diaplacental transport of nutritive allergens in vitroMonika Edelbauer
Department of Pediatrics, University of Vienna, Austria
Int Arch Allergy Immunol 130:25-32. 2003..We investigated the role of different allergen concentrations in influencing the diaplacental allergen transport in preterm and term placentas...
- Maternally transmitted antibodies to pregnancy-associated variant antigens on the surface of erythrocytes infected with Plasmodium falciparum: relation to child susceptibility to malariaMichel Cot
Mother and Child Health in the Tropics, Research Institute for Development, Hopital Tenon, Paris, France
Am J Epidemiol 157:203-9. 2003....
- Estimation of health effects of prenatal methylmercury exposure using structural equation modelsEsben Budtz-Jørgensen
Department of Biostatistics, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen, Denmark
Environ Health 1:2. 2002..This approach was used in a large epidemiological data set from a prospective study of developmental methyl-mercury toxicity...
- Detecting genotype combinations that increase risk for disease: maternal-fetal genotype incompatibility testJanet S Sinsheimer
Department of Human Genetics, University of California, Los Angeles, California 90095 1766, USA
Genet Epidemiol 24:1-13. 2003....
- Fetal immune responses to Plasmodium falciparum antigens in a malaria-endemic region of CameroonSimon Metenou
Department of Biology, Georgetown University, Washington, D C 20057, USA
J Immunol 178:2770-7. 2007..Because many infants living in a low transmission area are born with malaria-specific B and T cells, the influence of in utero priming on neonatal immunity merits further investigation...
- Distribution of PCBs and organochlorine pesticides in umbilical cord and maternal serumA Covaci
Toxicological Centre, University of Antwerp, Wilrijk, Belgium
Sci Total Environ 298:45-53. 2002..74 and 0.92, P<0.05). We conclude that all investigated organochlorine compounds have an efficient transplacental transfer...
- Disposition of orally administered 2,2-Bis(4-hydroxyphenyl)propane (Bisphenol A) in pregnant rats and the placental transfer to fetusesO Takahashi
Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Tokyo, Japan
Environ Health Perspect 108:931-5. 2000..These results suggest that the absorption and distribution of BPA in maternal organs and fetuses are extremely rapid and that the placenta does not act as a barrier to BPA...
- Maternal bone lead as an independent risk factor for fetal neurotoxicity: a prospective studyAhmed Gomaa
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Pediatrics 110:110-8. 2002..Our objective was to compare lead levels in umbilical cord blood and maternal bone as independent predictors of infant mental development using a prospective design...
- Human endothelial cells of the placental barrier efficiently deliver cholesterol to the fetal circulation via ABCA1 and ABCG1Jasminka Stefulj
Institute of Pathophysiology and Immunology, Center of Molecular Medicine, Medical University Graz, Graz, Austria
Circ Res 104:600-8. 2009..We propose a sequential pathway mediated by ABCA1 and ABCG1, respectively, by which HPECs participate in forming mature HDL in the fetal blood...
- Transplacentally acquired maternal T lymphocytes in severe combined immunodeficiency: a study of 121 patientsS M Muller
Department of Pediatrics, University of Ulm, Germany
Blood 98:1847-51. 2001..In this study, further understanding is provided of a phenomenon that is responsible for the significant heterogeneity of clinical and immunological findings in SCID...
- Localization of pro-inflammatory (IL-12, IL-15) and anti-inflammatory (IL-11, IL-13) cytokines at the foetomaternal interface during murine pregnancyS Zourbas
INSERM U131, Clamart, France
Clin Exp Immunol 126:519-28. 2001..Each of these molecules was found at the foetomaternal interface, with specific distributions and patterns of expression depending on both the cytokine itself and the stage of pregnancy. The significance of these data is discussed...
- Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary, and adrenal tumors in miceMichael P Waalkes
Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 186:7-17. 2003..The development of this rodent model of inorganic arsenic carcinogenesis has important implications in defining the mechanism of action for this common environmental carcinogen...
- Drugs of abuse in pregnancyA Wright
University Department of Obstetrics and Gynaecology, Leeds General Infirmary, Leeds, UK
Best Pract Res Clin Obstet Gynaecol 15:987-98. 2001..Where possible, evidence from trial data is included, but much of the what is quoted is descriptive from personal experience from ourselves and others working in the field...
- Human prenatal and postnatal exposure to polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorobiphenylols, and pentachlorophenolDaiva Meironyté Guvenius
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Environ Health Perspect 111:1235-41. 2003..Exposures to both PCBs and PBDEs, and in particular to the endocrine-active halogenated phenolic compounds, are of concern and implicate a potential risk for developmental disturbances...
- Breastfeeding, exposure to organochlorine compounds, and neurodevelopment in infantsNuria Ribas-Fito
Environmental and Respiratory Research Unit, Institut Municipal d Investigacio Medica, Barcelona, Spain
Pediatrics 111:e580-5. 2003..We studied the association between exposure to OCs and breastfeeding on neurodevelopment in the 1-year-old infants of this population...
- Transplacental transfer of schistosomal circulating anodic antigens in cowsS Gabriel
Department of Clinical Studies, School of Veterinary Medicine, University of Zambia, Box 32379, Lusaka, Zambia
Parasite Immunol 24:521-5. 2002..The suggested intrauterine antigenic stimulation may be important not only for generating immune responses to natural early infections, but also for enhancing the immunogenicity and efficacy of vaccines administered to newborns...
- Isolation from human placenta of the IgG transporter, FcRn, and localization to the syncytiotrophoblast: implications for maternal-fetal antibody transportJ L Leach
The Ohio State Biochemistry Program, The Ohio State University, Columbus 43210, USA
J Immunol 157:3317-22. 1996..Furthermore, the known characteristics of FcRn suggest a wider function, that it is the receptor postulated by Brambell in the 1960s to regulate tissue and serum IgG concentrations by controlling IgG transport and catabolism...
- Fas ligand is positioned in mouse uterus and placenta to prevent trafficking of activated leukocytes between the mother and the conceptusJ S Hunt
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City 66160, USA
J Immunol 158:4122-8. 1997..These observations are consistent with the idea that FasL at the maternal-fetal interface protects the placenta against a maternal leukocytic influx that reduces fertility...
- Transplacental exposure of neonates to perfluorooctanesulfonate and perfluorooctanoate: a pilot studyO Midasch
Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25, 91054, Erlangen, Germany
Int Arch Occup Environ Health 80:643-8. 2007..On the basis of the comparison of maternal and umbilical cord plasma sample pairs we wanted to examine whether infants are exposed to PFOS and PFOA via their mothers' blood...
- Threshold of trichloroethylene contamination in maternal drinking waters affecting fetal heart development in the ratPaula D Johnson
University Animal Care, University of Arizona, Tucson, Arizona, USA
Environ Health Perspect 111:289-92. 2003..e., < 250 ppb). Maternal rats exposed to more than this level of TCE during pregnancy showed an associated increased incidence of cardiac malformations in their developing rat fetuses...
- Correlation between blood mercury levels in mothers and newborns in Itaituba, Pará State, BrazilElisabeth Oliveira Santos
Seção de Meio Ambiente, Instituto Evandro Chagas, Ananindeua, Brasil
Cad Saude Publica 23:S622-9. 2007..8019; p = 0.000), with a significant linear regression model (r = 0.5283; p = 0.000). The results highlight the importance of monitoring pregnant women exposed to mercury as part of public health surveillance...
- Utilizing Ethyl Nitrate Gas in Laparoscopic SurgeryJames Reynolds; Fiscal Year: 2006..abstract_text> ..
- MOLECULAR BASIS OF PLACENTAL WATER AND SOLUTE TRANSPORTNICHOLAS ILLSLEY; Fiscal Year: 1993....
- 14th International Society for Prenatal Diagnosis MeetingDIANA BIANCHI; Fiscal Year: 2008..As a result of the conference, participants will be able to identify limitations and gaps in current practice and knowledge and develop a research agenda going forward. [unreadable] [unreadable] [unreadable]..
- DECIDUAL CELL/PLACENTAL INTERACTIONSJOAN HUNT; Fiscal Year: 2007..abstract_text> ..
- BIOMARKERS OF GENETIC DAMAGE AND ANTIOXIDANTFrederica Perera; Fiscal Year: 2001..Once validated in this model population, these biomarkers would also have applicability in evaluating interventions in occupational cohorts and other populations highly exposed to carcinogens. ..
- VULNERABILITY OF THE FETUS/INFANT TO PAH, PM2.5 AND ETS.Frederica Perera; Fiscal Year: 2004....
- STRATEGIES FOR PRIMATE TRANSGENESISThaddeus Golos; Fiscal Year: 2003..abstract_text> ..
- Fetal Velocimetry & Amino Acid Transport in PregnancyFREDERICK BATTAGLIA; Fiscal Year: 2007..These studies will establish important links between blood flow changes in the fetus and nutrient delivery to the fetus. ..
- A 3D C57BL6/J MOUSE BRAIN ATLAS MAGNETIC RESONANCE MICROHelene Benveniste; Fiscal Year: 2001..Further, a probabilistic (averaged from many brain specimens) atlas with error estimations will be created for registration of actual gene-expression data. ..
- A Primate Model of Maternal Fetal Immune ToleranceThaddeus Golos; Fiscal Year: 2006..The successful implementation of our recent adaptation of transgenic technology to the primate placenta will provide unprecedented opportunity for novel models of primate placental biology. ..
- UTERINE NK CELLS IN PRIMATE PREGNANCYThaddeus G Golos; Fiscal Year: 2010..for an important role of placental MHC class I molecules in the maternal immunological response to pregnancy in primates, and will further study the mechanisms and significance of these responses with two specific aims: ..
- Human Biology Association 2002 Annual MeetingLORNA MOORE; Fiscal Year: 2002..abstract_text> ..
- A PRIMATE ES CELL MODEL FOR EMBRYO IMPLANTATIONThaddeus Golos; Fiscal Year: 2009..abstract_text> ..
- A 3D C57BL6/J MOUSE BRAIN ATLAS MAGNETIC RESONANCE MICROHelene Benveniste; Fiscal Year: 2003..Further, a probabilistic (averaged from many brain specimens) atlas with error estimations will be created for registration of actual gene-expression data. ..
- ES CELL MODEL FOR PLACENTAL DEVELOPMENTThaddeus Golos; Fiscal Year: 2006..This proposal will allow us to develop the tools to advance a novel system for the study of primate placental biology. [unreadable] [unreadable]..
- Behavioral Effects of Gestational Inhalant Abuse in RatsScott Bowen; Fiscal Year: 2006..Finally, this research has the potential to assist in the design of effective treatments for inhalant abuse. [unreadable] [unreadable]..
- Mechanisms By Which Maternal And Fetal Drug Exposure Is*Jashvant Unadkat; Fiscal Year: 2006..Once tested, we will be able to predict the magnitude of change in dose that should be instituted for a wide range of drugs whose disposition is significantly modulated by these transporters. ..
- Mesenchymal Stem Cells for Fetal Gene DeliveryAlice Tarantal; Fiscal Year: 2006..abstract_text> ..
- ALCOHOL EFFECT ON HUMAN LACTATION AND INFANT BEHAVIORJULIE MENNELLA; Fiscal Year: 2007..AIM 3: To explore the role of early experiences with ethanol in mothers' milk and the emotional context of such experiences, on the recognition of, and preference for, the sensory properties of ethanol ..
- Nutrition, Fetal Growth, and Placental AngiogenesisLawrence P Reynolds; Fiscal Year: 2010..abstract_text> ..
- Mechanism of aPL antibody-induced Pregnancy lossJane E Salmon; Fiscal Year: 2010..Additionally, understanding how aPL antibodies "cause" pregnancy loss may translate into new concepts about maternal-fetal tolerance and miscarriages in general and benefit women with non-APS- related pregnancy complications. ..
- Bipolar Disorder in Pregnancy: Predictors of MorbidityDONALD NEWPORT; Fiscal Year: 2009..Furthermore, the novel PK data will expand our understanding of prenatal drug metabolism, and the project will establish a cohort of children of women with BPD with detailed prospective prenatal histories. ..
- NUTRITIONAL COPPER STATUS AND THE NERVOUS SYSTEMJOSEPH ROBERT PROHASKA; Fiscal Year: 2010..AIM 4: We will test the hypothesis that limitation in Cu-dependent ferroxidases lead to lower brain iron and are responsible by comparing rats reared on an iron-fortified diet to restore brain iron. ..
- Center for Pediatric Stem/Progenitor Cell Translational ResearchAlice Tarantal; Fiscal Year: 2008..If imaging techniques can be developed that allows one to monitor the cells over time, this would provide a very powerful tool to determine the fate of the cells after injection into humans. ..
- Nucleoside Transporters: disposition of nucleoside drugsJashvant Unadkat; Fiscal Year: 2008..abstract_text> ..
- Maternal Influence in the Development of AsthmaEdward Barrett; Fiscal Year: 2008..This application will provide new insight into the underlying mechanisms that contribute to the development of asthma and identify new targets for preventative therapies. ..
- Complement as a Mediator of Recurrent MiscarriagesJane Salmon; Fiscal Year: 2008..In addition, our studies will provide insights into mechanisms by which complement-induces disease and suggest means to prevent, arrest, or modify complement-mediated inflammatory disorders. [unreadable] [unreadable]..
- IMMUNE PROTECTION AGAINST MNU-INDUCTED DIGITAL DEFECTSMARY PRATER; Fiscal Year: 2006..This research under the guidance of Drs. Steven Holladay and Eric Wong at Virginia Tech...
- Fetal Determinants of AtherosclerosisWulf Palinski; Fiscal Year: 2006..These studies should yield fundamentally new insights into in utero programming and atherogenic mechanisms, and may establish a novel preventive approach. ..
- INTRAUTERINE ASPHYXIAL ENCEPHALOPATHYPeter Gluckman; Fiscal Year: 2001..By further elucidating the pathogenesis of prenatal and perinatal asphyxial encephalopathy these studies will provide important information towards improving perinatal diagnosis, monitoring and intervention. ..
- Targets for New Therapeutics for SLEJane Salmon; Fiscal Year: 2002..abstract_text> ..
- ETHANOL, RETINOIDS, AND CONGENITAL HEART MALFORMATIONSJanee Gelineau van Waes; Fiscal Year: 2003..abstract_text> ..
- Validation of biomarkers of prenatal pesticides exposureRobin Whyatt; Fiscal Year: 2003....
- Enhance Effectiveness of Anti-HIV Drugs in the CNSJashvant Unadkat; Fiscal Year: 2003..To test our hypothesis, using PET, that inhibition of P-gp in creases the exposure of CNS to l"1CJ-verapamil and, by inference, protease inhibitors. ..
- Cognitive dysfunction in neuropsychiatric-SLEMichael Lockshin; Fiscal Year: 2002..Successful completion of this research will redefine the pathogenesis of cognitive dysfunction and suggest therapeutic targets for intervention...
- THE MAJOR ANGIOGENIC FACTORS IN PLACENTAL ANGIOGENESISLawrence Reynolds; Fiscal Year: 2004..abstract_text> ..
- Self-administration of abused inhalants in miceScott Bowen; Fiscal Year: 2004....
- A Preclinical Model of Adolescent Toluene Abuse in RatsScott Bowen; Fiscal Year: 2005..The model also has the potential to assist in devising effective treatments and prevention strategies for adolescent inhalant abuse. ..
- Center for Fetal Gene Transfer for HLB DiseasesAlice Tarantal; Fiscal Year: 2005..abstract_text> ..
- Prenatal Insecticide Exposures Among Urban MinoritiesRobin Whyatt; Fiscal Year: 2005..The research will provide important information about pesticide exposure during pregnancy among this minority cohort. ..
- Development PsychopharmacologyDONALD NEWPORT; Fiscal Year: 2005..These study procedures will furthermore be applicable to future research investigating other classes of psychotropic medications. ..
- Mechanism for maternal transfer of asthma riskRobert Lim; Fiscal Year: 2007..Third, dendritic cell gene expression patterns between these two groups will be compared using gene arrays ..
- Adapting CHAMP+ for South Africa: Supporting HIV-Infected Youth and FamiliesClaude Mellins; Fiscal Year: 2008..The findings can be used to inform larger-scale effectiveness studies in similar settings. [unreadable] [unreadable] [unreadable]..
- OXIDATIVE STRESS, ANTIOXIDANT STATUS & PREGNANCY OUTCOMETheresa Scholl; Fiscal Year: 2005....
- Molecular mechanism of ADNF and ADNP peptides in neuroprotection to alcoholYoussef Sari; Fiscal Year: 2008..This data will shed light on the mechanisms governing brain ontogeny and will pave the path toward potential therapeutics against developmental insults associated with prenatal alcohol exposure. [unreadable] [unreadable] [unreadable]..
- Fas/FasL System In Normal Mammary Gland DevelopmentGil Mor; Fiscal Year: 2003..With an improved foundation of the normal mammary physiology, we can advance the understanding of breast cancer, allowing the development of effective strategies for its treatment and prevention. ..
- Acquisition of a Confocal/Multiphoton Microscopy SystemRobert Burghardt; Fiscal Year: 2006..This new technology will provide faculty, postdoctoral fellows and students with access to a state-of-the-art imaging facility and will facilitate the ongoing research of the major and minor users. [unreadable] [unreadable] [unreadable]..
- CONSTRUCTION OF RESEARCH ANIMAL FACILITYDonald Wilson; Fiscal Year: 2002..The proposed project, which will be co-financed by contributions from the State of Maryland, therefore, considered instrumental for sustaining the stature of the MPRC in schizophrenia research. ..
- Improving primary care to prevent childhood obesityMatthew Gillman; Fiscal Year: 2009....
- Prenatal factors and risk of autism in a Finnish national birth cohortALAN STEWART BROWN; Fiscal Year: 2010....
- Immune Tolerance; Sigma Receptor as a Therapeutic TargetVadivel Ganapathy; Fiscal Year: 2003....
- SHORT-TERM RESEARCH TRAINING FOR MINORITY STUDENTSCharles Wood; Fiscal Year: 2008..The emphasis of this training program in the next five years will be to significantly expand the students' horizons and to recruit students into basic biomedical science. ..
- Neurohormonal Effects of Massage TherapyTiffany Field; Fiscal Year: 2007..The K05 would allow me to increase my research time including being mentored and mentoring students from 25 to 75% time. [unreadable] [unreadable] [unreadable]..
- Paraxanthine and Reproductive Effects of CaffeineMichael Bracken; Fiscal Year: 2004..abstract_text> ..
- Diet Impacts Nutrient Transfer to Subsequent GenerationsDonald Novak; Fiscal Year: 2004..abstract_text> ..
- MECHANISMS IN THE REGULATION OF SP-A GENE EXPRESSIONCAROLE MENDELSON; Fiscal Year: 2007..unreadable]..
- Aberrant Ovine Pancreatic Development in IUGR FetusesSean Limesand; Fiscal Year: 2007....
- Adaptation to long chain fatty acid oxidation deficiencyArnold Strauss; Fiscal Year: 2007..We will investigate its role by generating a HERS knockout in the last specific aim. ..
- Fetal and Neonatal Hemodynamics in IUGR PregnanciesHenry Galan; Fiscal Year: 2006..abstract_text> ..
- Methodological Research on Substance UseHeping Zhang; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Placenta: Ethanol and HIVRichard Miller; Fiscal Year: 2004..The experiments proposed will provide the first evidence on whether ethanol plays a role in direct transmission of the HIV virus to the fetus. ..
- DEVELOPMENT OF A HUMAN PLACENTA VILLOUS MICROPERFUSIONNICHOLAS ILLSLEY; Fiscal Year: 2002..This model will provide the basis for new investigations in placental transport, metabolism, and signaling and structural biology. ..
- Placenta Association of the Americas Conference GrantNICHOLAS ILLSLEY; Fiscal Year: 2007..Additional support is being sought from foundations and private corporations. ..
- Exploration of ETS Effects on Child Behavior and SleepKimberly Yolton; Fiscal Year: 2005..abstract_text> ..