animal pregnancy

Summary

Summary: The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH.

Top Publications

  1. ncbi Pregnancy-associated changes in genome-wide gene expression profiles in the liver of cow throughout pregnancy
    Chandana B Herath
    Laboratory of Reproductive Biology and Technology, National Institute of Agrobiological Sciences, Tsukuba City, Ibaraki 305 8602, Japan
    Biochem Biophys Res Commun 313:666-80. 2004
  2. ncbi Developmental control of iodothyronine deiodinases by cortisol in the ovine fetus and placenta near term
    Alison J Forhead
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom
    Endocrinology 147:5988-94. 2006
  3. ncbi C-type natriuretic peptide forms in the ovine fetal and maternal circulations: evidence for independent regulation and reciprocal response to undernutrition
    Timothy C R Prickett
    Department of Medicine, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch 8015, New Zealand
    Endocrinology 148:4015-22. 2007
  4. ncbi The parturition defect in steroid 5alpha-reductase type 1 knockout mice is due to impaired cervical ripening
    M S Mahendroo
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9032, USA
    Mol Endocrinol 13:981-92. 1999
  5. ncbi Lipid metabolism in pregnancy and its consequences in the fetus and newborn
    Emilio Herrera
    Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Madrid, Spain
    Endocrine 19:43-55. 2002
  6. ncbi Changes in water content, collagen degradation, collagen content, and concentration in repeated biopsies of the cervix of pregnant cows
    V N A Breeveld-Dwarkasing
    Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands
    Biol Reprod 69:1608-14. 2003
  7. ncbi Pregnancy recognition and conceptus implantation in domestic ruminants: roles of progesterone, interferons and endogenous retroviruses
    Thomas E Spencer
    Center for Animal Biotechnology andGenomics, Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Reprod Fertil Dev 19:65-78. 2007
  8. ncbi Remodeling of Kv4.3 potassium channel gene expression under the control of sex hormones
    M Song
    Department of Anesthesiology, School of Medicine, University of California at Los Angeles, California 90095 1778, USA
    J Biol Chem 276:31883-90. 2001
  9. ncbi Progesterone and placental hormone actions on the uterus: insights from domestic animals
    Thomas E Spencer
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843, USA
    Biol Reprod 71:2-10. 2004
  10. ncbi Biology of progesterone action during pregnancy recognition and maintenance of pregnancy
    Thomas E Spencer
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas AM University, College Station, Texas 77843 2471, USA
    Front Biosci 7:d1879-98. 2002

Research Grants

Detail Information

Publications199 found, 100 shown here

  1. ncbi Pregnancy-associated changes in genome-wide gene expression profiles in the liver of cow throughout pregnancy
    Chandana B Herath
    Laboratory of Reproductive Biology and Technology, National Institute of Agrobiological Sciences, Tsukuba City, Ibaraki 305 8602, Japan
    Biochem Biophys Res Commun 313:666-80. 2004
    ..In conclusion, we described fabrication of a bovine liver cDNA microarray, and demonstrate, for the first time, differential expression patterns of a large number of coregulated liver genes in parallel throughout pregnancy in the bovine...
  2. ncbi Developmental control of iodothyronine deiodinases by cortisol in the ovine fetus and placenta near term
    Alison J Forhead
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom
    Endocrinology 147:5988-94. 2006
    ..Some of the maturational effects of cortisol on deiodinase activity may be mediated by T3...
  3. ncbi C-type natriuretic peptide forms in the ovine fetal and maternal circulations: evidence for independent regulation and reciprocal response to undernutrition
    Timothy C R Prickett
    Department of Medicine, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch 8015, New Zealand
    Endocrinology 148:4015-22. 2007
    ..Reciprocal increases in maternal CNP forms may reflect the response of the uteroplacental unit to substrate deficiency. CNP may have a role in maintaining fetal welfare and provides a possible marker of uteroplacental nutrient supply...
  4. ncbi The parturition defect in steroid 5alpha-reductase type 1 knockout mice is due to impaired cervical ripening
    M S Mahendroo
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9032, USA
    Mol Endocrinol 13:981-92. 1999
    ....
  5. ncbi Lipid metabolism in pregnancy and its consequences in the fetus and newborn
    Emilio Herrera
    Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Madrid, Spain
    Endocrine 19:43-55. 2002
    ..However, excessive intake of certain long chain fatty acids may cause both declines in arachidonic acid and enhanced lipid peroxidation, reducing antioxidant capacity...
  6. ncbi Changes in water content, collagen degradation, collagen content, and concentration in repeated biopsies of the cervix of pregnant cows
    V N A Breeveld-Dwarkasing
    Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands
    Biol Reprod 69:1608-14. 2003
    ....
  7. ncbi Pregnancy recognition and conceptus implantation in domestic ruminants: roles of progesterone, interferons and endogenous retroviruses
    Thomas E Spencer
    Center for Animal Biotechnology andGenomics, Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Reprod Fertil Dev 19:65-78. 2007
    ....
  8. ncbi Remodeling of Kv4.3 potassium channel gene expression under the control of sex hormones
    M Song
    Department of Anesthesiology, School of Medicine, University of California at Los Angeles, California 90095 1778, USA
    J Biol Chem 276:31883-90. 2001
    ..Thus, estrogen remodels the expression of Kv4.3 in myometrium by directly diminishing its transcription and, indirectly, by altering Kv4.3 delivery to the plasma membrane...
  9. ncbi Progesterone and placental hormone actions on the uterus: insights from domestic animals
    Thomas E Spencer
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843, USA
    Biol Reprod 71:2-10. 2004
    ..Strategic manipulation of these physiological mechanisms may offer therapeutic schemes to improve uterine capacity, conceptus survival, and reproductive health of domestic animals and humans...
  10. ncbi Biology of progesterone action during pregnancy recognition and maintenance of pregnancy
    Thomas E Spencer
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas AM University, College Station, Texas 77843 2471, USA
    Front Biosci 7:d1879-98. 2002
    ....
  11. ncbi Embryo-induced transcriptome changes in bovine endometrium reveal species-specific and common molecular markers of uterine receptivity
    Stefan Bauersachs
    Institute of Molecular Animal Breeding and Biotechnology, Ludwig Maximilians University, Feodor Lynen Str 25, 81377 Munich, Germany
    Reproduction 132:319-31. 2006
    ..A comparison with similar studies in humans, mice, and revealed species-specific and common molecular markers of uterine receptivity...
  12. ncbi Placental growth throughout the last two thirds of pregnancy in sheep: vascular development and angiogenic factor expression
    Pawel P Borowicz
    Center for Nutrition and Pregnancy, Department of Animal and Range Sciences, North Dakota State University, Fargo, North Dakota 58105 5727, USA
    Biol Reprod 76:259-67. 2007
    ..Monitoring the expression of angiogenic factors and correlating the levels with quantitative measures of vascularity enable one to model angiogenesis in a spatiotemporal fashion...
  13. ncbi Progesterone and gravidity differentially regulate expression of extracellular matrix components in the pregnant rat myometrium
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Biol Reprod 70:986-92. 2004
    ..These ECM changes contribute to myometrial growth and remodeling during late pregnancy and the preparation for the synchronized contractions of labor...
  14. ncbi Interferon-gamma contributes to the normalcy of murine pregnancy
    A A Ashkar
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Biol Reprod 61:493-502. 1999
    ..Furthermore, evidence is presented that IFN-gamma-producing cells exist in mesometrial regions of implantation sites that are neither NK nor T cells...
  15. ncbi Absence of natural killer cells during murine pregnancy is associated with reproductive compromise in TgE26 mice
    M J Guimond
    Department of Biomedical Sciences, University of Guelph, Ontario, Canada
    Biol Reprod 56:169-79. 1997
    ..These studies are the first to suggest a vital role for large granulated lymphocytes in the promotion of fetal survival and pregnancy success...
  16. ncbi Cathepsins in the ovine uterus: regulation by pregnancy, progesterone, and interferon tau
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, 442 Kleberg Center, 2471 TAMU, Texas A and M University, College Station, Texas 77843 2471, USA
    Endocrinology 146:4825-33. 2005
    ....
  17. ncbi The effects of spaceflight on mammary metabolism in pregnant rats
    K Plaut
    Department of Animal Science, University of Vermont, Burlington 05405, USA
    Proc Soc Exp Biol Med 222:85-9. 1999
    ..It is clear from these studies that spaceflight does not impair the normal development of the mammary gland, its ability to use glucose, nor the ability to express mRNA for a major milk protein...
  18. pmc Global gene expression analysis and regulation of the principal genes expressed in bovine placenta in relation to the transcription factor AP-2 family
    Koichi Ushizawa
    Reproductive Biology Research Unit, Division of Animal Sciences, National Institute of Agrobiological Sciences, 2 Ikenodai, Tsukuba, Ibaraki, Japan
    Reprod Biol Endocrinol 5:17. 2007
    ....
  19. ncbi The vitamin D receptor is not required for fetal mineral homeostasis or for the regulation of placental calcium transfer in mice
    Christopher S Kovacs
    Faculty of Medicine, Memorial University of Newfoundland, 300 Prince Philip Dr, St John s, Newfoundland and Labrador, Canada
    Am J Physiol Endocrinol Metab 289:E133-44. 2005
    ..Absence of maternal VDR has global effects on fetal growth that were partly dependent on maternal calcium intake, but absence of maternal VDR did not specifically affect fetal mineral homeostasis...
  20. pmc Pregnancy in the mature adult mouse does not alter the proportion of mammary epithelial stem/progenitor cells
    Kara L Britt
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
    Breast Cancer Res 11:R20. 2009
    ..However, the effects on stem/progenitor cell numbers in the mammary epithelium of a pregnancy in older animals have not yet been tested...
  21. ncbi Temporal and spatial expression of integrins and their extracellular matrix ligands at the maternal-fetal interface in the rhesus monkey during pregnancy
    Li Qin
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Haidian, Beijing 100080, China
    Biol Reprod 69:563-71. 2003
    ....
  22. ncbi Development of the inverted visceral yolk sac in three species of caviids (Rodentia, Caviomorpha, Caviidae)
    M A Miglino
    Department of Surgery, Faculty of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Placenta 29:748-52. 2008
    ..The variations established here must be considered if animal models for human placentation are required which have restricted access to the chorioallantoic placenta from the outside...
  23. ncbi Glucocorticoids prevent the normal increase in placental vascular endothelial growth factor expression and placental vascularity during late pregnancy in the rat
    Damien P Hewitt
    School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Endocrinology 147:5568-74. 2006
    ..Our data suggest that glucocorticoid-induced restriction of fetal and placental growth is mediated, in part, via inhibition of placental VEGF expression and an associated reduction in placental vascularization...
  24. ncbi Hormone-induced protection against mammary tumorigenesis is conserved in multiple rat strains and identifies a core gene expression signature induced by pregnancy
    Collin M Blakely
    Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    Cancer Res 66:6421-31. 2006
    ..Given the conservation of this signature, these pathways may contribute to pregnancy-induced protection against breast cancer...
  25. ncbi Temporal and spatial associations of oestrogen receptor alpha and progesterone receptor in the endometrium of cyclic and early pregnant mares
    L S Hartt
    Department of Animal and Veterinary Science, Center for Reproductive Biology, University of Idaho, Moscow, Idaho 83844 2330, USA
    Reproduction 130:241-50. 2005
    ..Results described here for temporal and spatial changes in steroid receptor gene expression in mares show the greatest similarities with those described for cattle and sheep...
  26. pmc Prevention of mammary carcinogenesis in rats by pregnancy: effect of full-term and interrupted pregnancy
    D K Sinha
    Department of Breast Surgery, Roswell Park Memorial Institute, Buffalo, New York 14263
    Br J Cancer 57:390-4. 1988
    ..These results indicate that the protective mechanism may not lie in the mammary gland per se, but may indeed be a host factor, such as hormonal or immunological changes occurring in the host as a result of the pregnancy...
  27. ncbi Utilization of different aquaporin water channels in the mouse cervix during pregnancy and parturition and in models of preterm and delayed cervical ripening
    Judy Anderson
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Endocrinology 147:130-40. 2006
    ..Together, these studies suggest that AQPs 3, 4, 5, and 8 regulate distinct aspects of cervical water balance during pregnancy and parturition...
  28. ncbi Expression of prolactin-related protein I at the fetomaternal interface during the implantation period in cows
    O Yamada
    Laboratory of Reproductive Biology and Technology, National Institute of Agrobiological Sciences, Ikenodai 2, Kukizaki, Inashiki Ibaraki 305 8602, Japan
    Reproduction 124:427-37. 2002
    ..These data indicate that bPRP-I may play a role before implantation and that bPRP-I may be an excellent marker for trophoblastic cell differentiation, as well as a candidate for pregnancy diagnosis...
  29. ncbi Placentation in the capybara (Hydrochaerus hydrochaeris), Agouti (Dasyprocta aguti) and paca (Agouti paca)
    M A Miglino
    Department of Surgery, School of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Placenta 23:416-28. 2002
    ..Lateral to its attachment to the placenta, the fetal surface was covered with non-vascular yolk sac endoderm. A layer of spongiotrophoblast cells was interposed between the endoderm and the marginal trophoblast...
  30. ncbi Gene expression and maintenance of pregnancy in bovine: roles of trophoblastic binucleate cell-specific molecules
    Kazuyoshi Hashizume
    Department of Veterinary Medicine, Iwate University, Ueda 3 18 8, Morioka, Iwate 020 8550, Japan
    Reprod Fertil Dev 19:79-90. 2007
    ..The results suggest that a well-orchestrated transcriptional command from binucleate cells is pivotal to the establishment and progression of pregnancy in cattle...
  31. ncbi Uterine TRPV6 expression during the estrous cycle and pregnancy in a mouse model
    Geun Shik Lee
    Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Research Institute of Veterinary Medicine, Chungbuk National University Cheongju, Chungbuk 361 763, Republic of Korea
    Am J Physiol Endocrinol Metab 293:E132-8. 2007
    ..In addition, we determined that ERalpha tightly regulated uterine TRPV6 transcription. Together, these results suggest that for uterine function in normal pregnancy, TRPV6 is regulated by E2 via an ERalpha-dependent pathway...
  32. pmc Gelatinase (MMP-2 and -9) expression profiles during gestation in the bovine endometrium
    Keiichiro Kizaki
    Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Iwate University, Ueda 3 18 8, Morioka, Iwate 020 8550, Japan
    Reprod Biol Endocrinol 6:66. 2008
    ..We examined MMP-2 and -9 expression using zymography, in situ hybridization, real-time PCR, and microarray analysis to clarify their roles in the bovine endometrium during gestation...
  33. pmc Insulin-like growth factor (IGF)-I obliterates the pregnancy-associated protection against mammary carcinogenesis in rats: evidence that IGF-I enhances cancer progression through estrogen receptor-alpha activation via the mitogen-activated protein kinase
    Gudmundur Thordarson
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, California, USA
    Breast Cancer Res 6:R423-36. 2004
    ..We investigated the effects of IGF-I on parity-associated protection against mammary cancer...
  34. ncbi Expression and localization of matrix metalloproteinases (MT1-MMP, MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) during synepitheliochorial placentation of goats (Capra hircus)
    T Uekita
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo 113 8657, Japan
    Placenta 25:810-9. 2004
    ....
  35. ncbi Maternal recognition of pregnancy signal or endocrine disruptor: the two faces of oestrogen during establishment of pregnancy in the pig
    R D Geisert
    Department of Animal Science, Oklahoma Agricultural Experiment Station, Oklahoma State University, Stillwater, OK 74078, USA
    Soc Reprod Fertil Suppl 62:131-45. 2006
    ..Early oestrogen administration alters the pattern of gene expression through the NF-kB system desynchronising the uterine environment for conceptus implantation resulting in later embryonic loss...
  36. ncbi Regulation of the Ca2+-sensitive domains of the maxi-K channel in the mouse myometrium during gestation
    N A Benkusky
    Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 275:27712-9. 2000
    ....
  37. pmc From feeding one to feeding many: hormone-induced changes in bodyweight homeostasis during pregnancy
    Rachael A Augustine
    Centre for Neuroendocrinology, School of Medical Sciences, University of Otago, PO Box 913, Dunedin, New Zealand
    J Physiol 586:387-97. 2008
    ....
  38. pmc Evidence that an early pregnancy causes a persistent decrease in the number of functional mammary epithelial stem cells--implications for pregnancy-induced protection against breast cancer
    Stefan K Siwko
    The Lester and Sue Smith Breast Center
    Stem Cells 26:3205-9. 2008
    ..Our results provide the first direct evidence that an early pregnancy has an effect on mammary stem cells...
  39. ncbi Transfer of maternally injected endocrine disruptors through breast milk during lactation induces neonatal Calbindin-D9k in the rat model
    Eui Ju Hong
    Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, 361 763, South Korea
    Reprod Toxicol 18:661-8. 2004
    ....
  40. ncbi Presence of the acute phase protein, bikunin, in the endometrium of gilts during estrous cycle and early pregnancy
    A M Hettinger
    Department of Animal Science, Oklahoma Agriculture Experiment Station, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Biol Reprod 65:507-13. 2001
    ....
  41. ncbi Deep, prolonged torpor by pregnant, free-ranging bats
    Craig K R Willis
    Centre for Behavioural and Physiological Ecology, Zoology, University of New England, Armidale, NSW 2351, Australia
    Naturwissenschaften 93:80-3. 2006
    ..Our observations imply a fitness advantage of torpor in addition to energy conservation because reduced foetal growth rate could delay parturition until conditions are more favourable for lactation and neonatal survival...
  42. ncbi Reproduction and embryonic diapause in a marsupial: insights from captive female Honey possums, Tarsipes rostratus (Tarsipedidae)
    J E Oates
    School of Animal Biology and Centre for Native Animal Research, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia
    Gen Comp Endocrinol 150:445-61. 2007
    ..Results from studying Honey possums in captive conditions suggest that the control of diapause in Tarsipes appears to be three-fold; lactational, photoperiodic and an entrained rhythm...
  43. ncbi Characterization of vascular endothelial growth factor (VEGF) in the uterine cervix over pregnancy: effects of denervation and implications for cervical ripening
    C N Mowa
    Dept of Neurobiology, Northeastern Ohio Universities College of Medicine, 4209 State RT 44, Rootstown, OH 44272, USA
    J Histochem Cytochem 52:1665-74. 2004
    ..Furthermore, angiogenic and sensory neuronal factors may be important in regulating the dynamic microvasculature in the ripening cervix and may subsequently play a role in cervical ripening and the birth process...
  44. ncbi Dynamic changes in the cervical epithelial tight junction complex and differentiation occur during cervical ripening and parturition
    Brenda C Timmons
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9032, USA
    Endocrinology 148:1278-87. 2007
    ....
  45. ncbi Delay of preterm birth in sheep by THG113.31, a prostaglandin F2alpha receptor antagonist
    Jonathan J Hirst
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    Am J Obstet Gynecol 193:256-66. 2005
    ..A novel prostaglandin F2alpha receptor antagonist, THG113.31, was tested for the suppression of uterine contractility and delay of preterm labor in sheep...
  46. ncbi Association of increased estrogen receptor beta2 expression with parity-induced alterations in the rat mammary gland
    Laura Kass
    Laboratorio de Endocrinologia y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, C C 242, 3000 Santa Fe, Argentina
    J Steroid Biochem Mol Biol 91:29-39. 2004
    ....
  47. ncbi Expression of porcine endometrial prostaglandin synthase during the estrous cycle and early pregnancy, and following endocrine disruption of pregnancy
    Morgan D Ashworth
    Department of Animal Science, Oklahoma Agricultural Experiment Station, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Biol Reprod 74:1007-15. 2006
    ....
  48. ncbi Maternal-fetal transfer of endocrine disruptors in the induction of Calbindin-D9k mRNA and protein during pregnancy in rat model
    Eui Ju Hong
    Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, 361 763 Chungbuk, South Korea
    Mol Cell Endocrinol 212:63-72. 2003
    ....
  49. ncbi Pregnancy in mice lacking the vitamin D receptor: normal maternal skeletal response, but fetal hypomineralization rescued by maternal calcium supplementation
    Katrien Rummens
    Department of Ob Gyn, Katholieke Universiteit Leuven, Belgium
    Pediatr Res 54:466-73. 2003
    ..Alternatively or additionally, elevated 1,25(OH)2D3 in utero may disturb bone development...
  50. ncbi Characterization of the interleukin-1beta system during porcine trophoblastic elongation and early placental attachment
    Jason W Ross
    Department of Animal Science, Oklahoma Agriculture Experiment Station, Stillwater 74078, USA
    Biol Reprod 69:1251-9. 2003
    ....
  51. ncbi Pregnancy in the brown Norway rat: a model for investigating the genetics of placentation
    Toshihiro Konno
    Institute of Maternal Fetal Biology, Division of Cancer and Developmental Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biol Reprod 76:709-18. 2007
    ..Collectively, the data indicate that BN rats exhibit a unique form of placentation and may represent an excellent model for investigating the genetics of placental development...
  52. ncbi Co-administration of dextromethorphan during pregnancy and throughout lactation significantly decreases the adverse effects associated with chronic morphine administration in rat offspring
    P L Tao
    Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Life Sci 69:2439-50. 2001
    ..If this effect of dextromethorphan is applied to clinical pregnant patients with morphine addiction or chronic pain, it will have a great value for the benefit of their children...
  53. ncbi Long-term nitric oxide synthase inhibition in rat pregnancy reduces renal kallikrein
    S P Salas
    Center for Medical Research, Department of Obstetrics and Gynecology, School of Medicine, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, Santiago
    Hypertension 34:865-71. 1999
    ..L-NAME rats exhibited similar alterations that were attenuated with an excess of L-arginine. We postulate that the reduction in renal kallikrein may contribute to the hemodynamic alterations described in this model...
  54. ncbi Expression of cyclooxygenase-1 and -2 in ovine endometrium during the estrous cycle and early pregnancy
    G Charpigny
    Laboratoire de Physiologie Animale, Institut National de la Recherche Agronomique, Jouy en Josas, France
    Endocrinology 138:2163-71. 1997
    ..Estradiol slightly increased cox-2 expression but only after progesterone priming. Collectively these results suggest that the developing ability of the uterus to synthesize PGs is due to the induction of cox-2...
  55. ncbi Expression of leukemia inhibitory factor receptor and gp130 in mouse uterus during early pregnancy
    Hua Ni
    College of Life Sciences, Northeast Agricultural University, Harbin, China
    Mol Reprod Dev 63:143-50. 2002
    ..The co-expression of a high level of LIFR and gp130 mRNA in the decidua may play a key role during the decidualization and placentation...
  56. ncbi Mechanism of action of interferon-tau in the uterus during early pregnancy
    T R Hansen
    Department of Animal Science, University of Wyoming, Laramie 82071, USA
    J Reprod Fertil Suppl 54:329-39. 1999
    ..Induction of these transcription factors, the alpha chemokines and UCRP is the prelude to maternal recognition of pregnancy in ruminants...
  57. ncbi Small leucine-rich proteoglycans (SLRPs) in uterine tissues during pregnancy in mice
    S San Martin
    Laboratory of Biology of Reproduction, Department of Histology and Embryology, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    Reproduction 125:585-95. 2003
    ..As decorin has been shown to inhibit lateral association of collagen fibrils, its disappearance between day 2 and day 5 of pregnancy may be a prerequisite for the formation of large fibrils in decidua in mice...
  58. ncbi Granulated metrial gland cells: hypotheses concerning possible functions during murine gestation
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    J Reprod Immunol 27:85-94. 1994
    ..A broader range of potential functions is discussed and shifts in functional roles played by GMG cells are proposed over the course of gestation...
  59. ncbi Demonstration of YAC target cell lysis by murine granulated metrial gland cells
    B A Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Cell Immunol 133:116-26. 1991
    ....
  60. ncbi Long-term hypoxia changes myometrial responsiveness and oxytocin receptors in the pregnant ewe: differential effects on longitudinal versus circular smooth muscle
    M Mlynarczyk
    Center for Perinatal Biology, Departments of Physiology Pharmacology and Pediatrics, Loma Linda University School of Medicine, Loma Linda, California 92350, USA
    Biol Reprod 69:1500-5. 2003
    ..Results from the present study indicate that LTH alters contractile responses and oxytocin-receptor protein expression in a layer-specific manner in the pregnant sheep myometrium...
  61. ncbi Small heat shock protein 27 (Hsp27) expression is highly induced in rat myometrium during late pregnancy and labour
    B G White
    Division of Basic Medical Sciences, Health Sciences Centre, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada A1B 3V6
    Reproduction 129:115-26. 2005
    ..Our results demonstrate that Hsp27 expression is highly upregulated during late pregnancy and labour and suggest that Hsp27 is a potential candidate contraction-associated protein...
  62. ncbi Topographical specialization of prostaglandin function in late pregnancy and at parturition in the baboon
    Peter W Nathanielsz
    Department of Obstetrics, Center for Women s Health Research, New York University Medical School, 550 1st Ave, New York 10016, USA
    Prostaglandins Leukot Essent Fatty Acids 70:199-206. 2004
    ....
  63. ncbi Expression and localization of alpha-smooth muscle and gamma-actins in the pregnant rat myometrium
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Biol Reprod 73:773-80. 2005
    ....
  64. ncbi Expression of alpha5 integrin (Itga5) is elevated in the rat myometrium during late pregnancy and labor: implications for development of a mechanical syncytium
    S J Williams
    Division of Basic Medical Sciences, Health Sciences Centre, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1B 3V6
    Biol Reprod 72:1114-24. 2005
    ..This process may aid the development of a mechanical syncytium for efficient force transduction during the sustained, coordinated, and powerful contractions of labor...
  65. ncbi Temporospatial expression of placental lactogen and prolactin-related protein-1 genes in the bovine placenta and uterus during pregnancy
    O V Patel
    Department of Developmental Biology, National Institute of Agrobiological Sciences, Ibaraki, Japan
    Mol Reprod Dev 69:146-52. 2004
    ....
  66. ncbi Leucocyte membrane antigens on mouse granulated metrial gland cells
    D D Mukhtar
    Human Morphology, Faculty of Medicine, University of Southampton, U K
    J Reprod Immunol 15:269-79. 1989
    ..GMG cells were found to express both the asialo-GM1 antigen and the Thy-1 antigen. GMG cells did not express the Lyt-1, Lyt-2, Mac-1, L3T4 or IgM antigens. These results provide new evidence that GMG cells are a type of NK cell...
  67. ncbi Synthesis and granular localization of tumor necrosis factor-alpha in activated NK cells in the pregnant mouse uterus
    E L Parr
    Department of Anatomy, Southern Illinois University School of Medicine, Carbondale 62901, USA
    J Reprod Immunol 28:31-40. 1995
    ....
  68. ncbi Expression of interleukin 1, interleukin 6 and tumour necrosis factor alpha in mouse uterus during the peri-implantation period of pregnancy
    M De
    Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City 66103
    J Reprod Fertil 97:83-9. 1993
    ..We conclude that the cytokines IL-1, IL-6 and TNF-alpha are produced in the uterus during the peri-implantation period of pregnancy in mice. Changes in cytokine concentrations suggested the existence of some form of regulated expression...
  69. ncbi Doppler evaluation of maternal and fetal vessels during normal gestation in the bitch
    P Di Salvo
    Department of Veterinary Pathology Clinical and Diagnostic, Section of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, University of Perugia, S Costanzo 4, 06100 Perugia, Italy
    Res Vet Sci 81:382-8. 2006
    ..This study can be considered a further contribution in diagnosing and monitoring high-risk pregnancies in Veterinary Medicine...
  70. ncbi Progesterone and interferon-tau regulate cystatin C in the endometrium
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, 442 Kleberg Center, 2471 TAMU, Texas A and M University, College Station, 77843 2471, USA
    Endocrinology 147:3478-83. 2006
    ..These results indicate that CST3 is a novel P4-induced and IFNT-stimulated gene expressed only in the epithelial cells of the ovine endometrium and implicate CST3 in regulation of uterine cathepsin activity during conceptus implantation...
  71. ncbi Increased Th1/Th2 (IFN-gamma/IL-4) Cytokine mRNA ratio of rat embryos in the pregnant mouse uterus
    Chang Long Nan
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China
    J Reprod Dev 53:219-28. 2007
    ..The IFN-gamma and IL-4 mRNA expressions indicate that there is a Th1/Th2 imbalance in the feto-maternal interface of interspecific pregnancies. Bias of Th1 cytokine dominance may be a barrier to reproductive success between species...
  72. ncbi Doppler evaluation of maternal and foetal vessels during normal gestation in queen
    L Scotti
    Via San Costanzo 4, Perugia, Italy
    Theriogenology 69:1111-9. 2008
    ..This study can be considered the basis for further contribution in diagnosing and monitoring high-risk pregnancies in Veterinary Medicine...
  73. ncbi Effect of interferon-tau administration on endometrium of nonpregnant ewes: a comparison with pregnant ewes
    Yizhen Chen
    Department of Animal Sciences, University of Missouri, Columbia, 65211, USA
    Endocrinology 147:2127-37. 2006
    ..IFNT treatment mimics pregnancy, but relatively high doses of im-injected IFNT are required to elicit a full endometrial response...
  74. ncbi Pregnancy, bovine somatotropin, and dietary n-3 fatty acids in lactating dairy cows: I. Ovarian, conceptus, and growth hormone-insulin-like growth factor system responses
    T R Bilby
    Department of Animal Sciences, University of Florida, Gainesville, Florida 32611, USA
    J Dairy Sci 89:3360-74. 2006
    ..In summary, bST and FO seemed to modulate reproductive responses that may be beneficial to the developing conceptus and pregnancy rate...
  75. ncbi Quantitative analysis of messenger RNA expression of matrix metalloproteinases (MMP-2 and MMP-9), tissue inhibitor-2 of matrix metalloproteinases (TIMP-2), and steroidogenic enzymes in bovine placentomes during gestation and postpartum
    M Takagi
    Laboratory of Farm Animal Production Medicine, Kagoshima University, Kagoshima, Japan
    Mol Reprod Dev 74:801-7. 2007
    ....
  76. pmc Fetal well-being assessment in bovine near-term gestations: current knowledge and future perspectives arising from comparative medicine
    Sébastien M C Buczinski
    Departement des Sciences Cliniques, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Quebec
    Can Vet J 48:178-83. 2007
    ..Measurements of different fetal parameters (thoracic aorta, metacarpal or metatarsal thickness) could be reliable tools for early detection of the large offspring syndrome commonly found in cloned calves...
  77. ncbi Altered placental and fetal expression of IGFs and IGF-binding proteins associated with intrauterine growth restriction in fetal sheep during early and mid-pregnancy
    Barbra de Vrijer
    Department of Obstetrics and Gynecology, Division of Obstetrics and Prenatal Medicine, Erasmus University Medical Center, 3000 CB Rotterdam, The Netherlands
    Pediatr Res 60:507-12. 2006
    ..These data suggest that changes in placental IGF expression in early and mid gestation may predispose the pregnancy to placental insufficiency, resulting in inadequate substrate supply to the developing fetus later in gestation...
  78. pmc Altered endothelin receptor binding in response to nitric oxide synthase inhibition in the pregnant rat
    Mark G Neerhof
    Department of Obstetrics, Evanston Northwestern Healthcare, Evanston, Illinois, USA
    Reprod Sci 15:366-73. 2008
    ..ET-1, a prominent mediator during NOS inhibition, is not of uterine or placental origin. Reduced receptor binding activity is the primary means by which these tissues regulate their response to ET-1 in the setting of NOS inhibition...
  79. ncbi Differences in placental structure during gestation associated with large and small pig fetuses
    J L Vallet
    USDA, ARS, Roman L Hruska US Meat Animal Research Center, Clay Center, NE 68933, USA
    J Anim Sci 85:3267-75. 2007
    ....
  80. pmc Restriction of placental growth in sheep impairs insulin secretion but not sensitivity before birth
    Julie A Owens
    Department of Physiology, University of Adelaide, SA, Australia
    J Physiol 584:935-49. 2007
    ....
  81. ncbi ACE2 and ANG-(1-7) in the rat uterus during early and late gestation
    Liomar A A Neves
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Am J Physiol Regul Integr Comp Physiol 294:R151-61. 2008
    ....
  82. ncbi Number of fetuses and conceptus growth throughout gestation in lines of pigs selected for ovulation rate or uterine capacity
    B A Freking
    USDA, ARS, US Meat Animal Research Center, Clay Center, NE 68933 0166, USA
    J Anim Sci 85:2093-103. 2007
    ..Relative growth rate coefficients throughout gestation for placental tissue indicated a change in rank of the line means, implicating a relative later growth pattern of placental tissue in the UC line...
  83. ncbi Effects of calcitonin and parathyroid hormone on the regulation of cabindin-D(9k) in the uterus, placenta, and fetal membrane of rats related to blood calcium level during late gestation
    Eui Ju Hong
    Laboratory of Veterinary Biochemistry and Molecular Biotechnology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
    Mol Reprod Dev 74:1188-97. 2007
    ..In addition, an increase of blood calcium level is one of the most significant factors in the regulation of CaBP-9k at the transcriptional and/or translational levels in the reproductive tissues during late pregnancy...
  84. ncbi Early embryo survival and development in sows with lactational ovulation
    R Gerritsen
    Adaptation Physiology, Animal Sciences Group, Wageningen University, Wageningen, The Netherlands
    Reprod Domest Anim 43:59-65. 2008
    ..Embryo development, however, was negatively affected in IS6 sows possibly due to a combination of high milk production, stress and lactational effects on uterine development...
  85. ncbi Conceptus-related measurements during the first trimester of bovine pregnancy
    George A Riding
    CSIRO Livestock Industries, Queensland Bioscience Precinct, St Lucia, QLD 4067, Australia
    Vet J 175:266-72. 2008
    ..The amniotic compartment and fetometric data presented here have both research and clinical value, particularly in relation to fetal development evaluation and pregnancy viability diagnosis...
  86. ncbi Assessment of the factors affecting the volume of fetally derived tissue in the bovine placentome
    R A Laven
    Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11222, Palmerston North, New Zealand
    Vet Rec 159:82-3. 2006
  87. ncbi Efficacy of HCG and ovarian steroids in the maintenance/interruption of pregnancy in-albino rats
    S A Nevagi
    Department of Zoology, Karnatak University, Dharwad 580 003, India
    J Basic Clin Physiol Pharmacol 16:287-99. 2005
    ..The results indicate that these steroids cannot prevent the interruption of pregnancy induced by the continuous administration of HCG, possibly due to an overstimulation of the ovaries by gonadotrophin...
  88. ncbi Cloning of rabbit prolactin cDNA and prolactin gene expression in the rabbit mammary gland
    L Gabou
    Laboratoire de Biologie Cellulaire et Moleculaire, Institut National de la Recherche Agronomique, Jouy en Josas, France
    J Mol Endocrinol 16:27-37. 1996
    ..A strong PCR signal was detected in the mammary gland of virgin does and was also observed during pregnancy and at the beginning of lactation. This PCR signal was very weak in mid-lactating and absent in post-weaning mammary gland...
  89. ncbi Osteopontin is synthesized by uterine glands and a 45-kDa cleavage fragment is localized at the uterine-placental interface throughout ovine pregnancy
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 69:92-8. 2003
    ....
  90. ncbi Differential metabolic response to 48 h food deprivation at different periods of pregnancy in the rat
    L López-Soldado
    Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Boadilla del Monte, Madrid, Spain
    J Physiol Biochem 58:75-85. 2002
    ....
  91. ncbi Isolation and characterisation of the ovine gastrin-releasing peptide gene; abundant expression in the pregnant uterus and selective expression in fetal tissues
    J C Whitley
    University of Melbourne, Department of Surgery, Austin and Repatriation Medical Centre, Austin Campus, Heidelberg, Victoria 3084, Australia
    J Endocrinol 175:447-57. 2002
    ..The expression of GRP in the fetal lung was biphasic with peaks at mid-term and near parturition but none in the adult supporting the concept of a specific developmental role of GRP in the lung...
  92. ncbi Evidence that absence of endometrial gland secretions in uterine gland knockout ewes compromises conceptus survival and elongation
    C A Gray
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, College Station 77843 2471, USA
    Reproduction 124:289-300. 2002
    ....
  93. ncbi Interrelationships among conceptus size, uterine protein secretion, fetal erythropoiesis, and uterine capacity
    J L Vallet
    USDA, ARS, Roman L Hruska US Meat Animal Research Center, NE 68933 0166, USA
    J Anim Sci 80:729-37. 2002
    ..These results also suggest that reducing placental and fetal weights will likely result in increased uterine capacity...
  94. ncbi Leptin in the ovine fetus correlates with fetal and placental size
    A Buchbinder
    Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Cincinnati College of Medicine, OH, USA
    Am J Obstet Gynecol 185:786-91. 2001
    ..Fetal leptin concentrations were inversely related to uterine blood flow and fetal and placental weight. These findings suggest that fetal leptin may be involved in an adaptive response to intrauterine growth restriction...
  95. ncbi Effects of helium pneumoperitoneum in pregnant ewes
    M J Curet
    Department of Surgery, ACC-2, University of New Mexico School of Medicine, 2211 Lomas Boulevard NE, Albuquerque, NM, 87131, USA
    Surg Endosc 15:710-4. 2001
    ..Therefore, He may be a safer gas than CO(2) to use for laparoscopic procedures in pregnant patients...
  96. ncbi In vivo evidence for stimulation of placental, myometrial, and endometrial prostaglandin G/H synthase 2 by fetal cortisol replacement after fetal adrenalectomy
    W X Wu
    Laboratory for Pregnancy and Newborn Research, Cornell University College of Veterinary Medicine, Ithaca, New York 14853, USA
    Endocrinology 142:3857-64. 2001
    ....
  97. ncbi Establishment of the prediction table of parturition day with ultrasonography in small pet dogs
    C H Son
    College of Veterinary Medicine, Chonnam National University, Kwangju, Republic of Korea
    J Vet Med Sci 63:715-21. 2001
    ..1%) delivered within I day of the date predicted. Therefore, the prediction table of parturition day seems to be a useful tool of the prediction of parturition day in practice...
  98. ncbi Molecular cloning of the bovine prolactin receptor and distribution of prolactin and growth hormone receptor transcripts in fetal and utero-placental tissues
    P Scott
    Department of Comparative Biosciences, University of Wisconsin, Madison 53706
    Mol Cell Endocrinol 89:47-58. 1992
    ..This isolation of bovine prolactin receptor cDNA, and description of receptor distribution will facilitate study of the action of the placental and pituitary members of this gene family during pregnancy...
  99. ncbi Fetoplacental growth in sheep administered progesterone during the first three days of pregnancy
    D O Kleemann
    South Australian Research and Development Institute, Turretfield Research Centre, Rosedale S.A. 5350, Australia
    Placenta 22:14-23. 2001
    ..It is concluded that alteration of the embryo's environment during the first few days of development enhances fetal growth disproportionately, in close association with increased abundance of the exchange epithelia in the placenta...
  100. ncbi Molecular cloning of ovine and bovine type I interferon receptor subunits from uteri, and endometrial expression of messenger ribonucleic acid for ovine receptors during the estrous cycle and pregnancy
    C S Han
    Department of Biochemistry, University of Missouri, Columbia 65211, USA
    Endocrinology 138:4757-67. 1997
    ..These data suggest that the type I IFN receptor, which is expressed by the endometrium and binds IFN-tau, is probably not a structurally unusual form...
  101. pmc Pepsin-inhibitory activity of the uterine serpins
    N Mathialagan
    Department of Animal Sciences, University of Missouri, Columbia 65211, USA
    Proc Natl Acad Sci U S A 93:13653-8. 1996
    ....

Research Grants70

  1. TRH AND GLUCOCORTICOID ACTIONS ON THE FETAL LUNG
    Peter Nathanielsz; Fiscal Year: 2000
    ..g. presence of infection). In addition, recent observations in human and animal pregnancy show that maternal GC administration has significant extra-pulmonary effects on fetal maturation affecting ..
  2. Mechanisms of uterine vascular adaptation in pregnancy
    Natalia Gokina; Fiscal Year: 2006
    ..abstract_text> ..
  3. NEUROPEPTIDES AND CARDIOVASCULAR REGULATION
    VIRGINIA BROOKS; Fiscal Year: 2002
    ....
  4. Humoral Interactions in long-term blood pressure control
    VIRGINIA BROOKS; Fiscal Year: 2005
    ..abstract_text> ..
  5. Multidisciplinary Program in Female and Male Reproduction
    EUGENE ALBRECHT; Fiscal Year: 2008
    ..The discoveries obtained in the baboon primate model are expected to translate to the human to advance knowledge of human reproductive biology. [unreadable] [unreadable]..
  6. Genetic Regulation of Postnatal Uterine Morphogenesis and Function
    Thomas Spencer; Fiscal Year: 2008
    ..This research will help determine important genes for reproduction and help to design clinical therapies to prevent, identify and treat reproductive problems in women. [unreadable] [unreadable] [unreadable]..
  7. MECHANISMS REGULATING UTERINE MORPHOGENESIS
    Thomas Spencer; Fiscal Year: 2004
    ....
  8. RENAL INTERSTITIAL HYDROSTATIC PRESSURE IN PREGNANCY
    ALI KHRAIBI; Fiscal Year: 2003
    ....
  9. 2004 Reproductive Tract Biology Gordon Conference
    Asgerally Fazleabas; Fiscal Year: 2004
    ..The continued ability to meet with the Mammalian Gametogenesis and Embryogenesis Conference at the same site will further enhance the quality of this meeting, which has consistently been highly rated by the attendees. ..
  10. Fetal Membrane AQP Expression/Amniotic Fluid Regulation
    Michael Ross; Fiscal Year: 2004
    ..Our objective is to determine the regulatory mechanisms of fetal membrane AQP expression and delineate the role of AQPs in AF homeostasis. ..
  11. Uterine circulatory response to exercise in pregnancy
    KATHLEEN O HAGAN; Fiscal Year: 2004
    ..abstract_text> ..
  12. Low birth weight, uterine infection, and nitric oxide
    Chandrasekhar Yallampalli; Fiscal Year: 2007
    ..2 will test the hypothesis that NO donor can reverse the increases in DAF expression in uteroplacental and vascular tissues and in fetal growth restriction ..
  13. Fetal Swallowing: Central Dipsogenic Mechanisms
    Michael Ross; Fiscal Year: 2007
    ..Furthermore, these studies represent a model to examine the development and function of neuronal pathways and mechanisms regulating fetal physiology. ..
  14. Uterine Vascular Adaptation to Pregnancy
    Lubo Zhang; Fiscal Year: 2005
    ..Such an understanding has obvious clinical implications because the maladaptation of uterine circulation to pregnancy is associated with fetal developmental abnormalities and maternal cardiovascular disorders. ..
  15. Thrombin-Stimulated Intrauterine Signaling Pathway
    Mark Phillippe; Fiscal Year: 2007
    ..These studies are anticipated to significantly improve our understanding of the mechanisms underlying preterm labor in the presence of intrauterine infection. ..
  16. Cortisol at MR Mediate Fetal Physiologic/Genomic Effects
    Maureen Keller Wood; Fiscal Year: 2007
    ..abstract_text> ..
  17. CONTROL OF CORTICOTROPIN DURING PREGNANCY
    Maureen Keller Wood; Fiscal Year: 2006
    ..Finally, the ability of progesterone to inhibit MR activation will be tested in gel-shift and super-shift assays using specific response elements in the 5HT1A promoter, including a nGRE and the SP-1 site. ..
  18. Cocaine and Apoptosis in the Developing Heart
    Lubo Zhang; Fiscal Year: 2004
    ..Such an understanding has obvious clinical implications because the increasing information has pointed to an important role of apoptosis in cardiovascular diseases. ..
  19. Prenatal Cocaine Exposure and Cardiac Programming
    Lubo Zhang; Fiscal Year: 2009
    ..abstract_text> ..
  20. PI/PLC FUNCTION IN PREGNANT RAT MYOMETRIUM
    Mark Phillippe; Fiscal Year: 2002
    ..s. ..
  21. Parenting, Sibling-Support, and Infant Development
    Jeffrey French; Fiscal Year: 2008
    ..Finally, we will carefully document qualitative patterns of offspring care toward infants that differ in chimeric status. ..
  22. LEPTIN & NEUROPEPTIDE-Y ALTERS FETAL SWALLOWING ACTIVITY
    Michael Ross; Fiscal Year: 2002
    ..In addition, these studies represent a model to examine the development and function of neuronal pathways and mechanisms which regulate fetal physiology. ..
  23. NEUROENDOCRINE/IMMUNE INTERACTIONS: ROLE OF MELATONIN
    STEVEN YELLON; Fiscal Year: 2002
    ....
  24. MATERNAL DEHYDRATION--FETAL/AMNIOTIC FLUID HOMEOSTASIS
    Michael Ross; Fiscal Year: 2002
    ..The goal of this project is to determine critical efficacy and fetal safety issues central to maternal DDAVP treatment, prior to widespread clinical use in human pregnancies with oligohydramnios. ..
  25. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2009
    ....
  26. DECIDUALIZATION IN THE BABOON
    Asgerally Fazleabas; Fiscal Year: 2003
    ....
  27. STEROIDS /VASCULAR REACTIVITY /NITRIC OXIDE PRODUCTION
    Maureen Keller Wood; Fiscal Year: 2002
    ..These studies will also to our understanding of the counterbalancing effects of increased cortisol and increased estrogens in control of normal blood pressure in normal pregnancy. ..
  28. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2003
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  29. PREVENTION AND TREATMENT OF HUMAN OLIGOHYDRAMNIOS
    Michael Ross; Fiscal Year: 2001
    ..e., failure to reset osmolality threshold). This proposal will aid in the development of markers of prediction and therapeutic approaches to the prevention and treatment of human oligohydramnios. ..
  30. MATERNAL CORTICOSTEROIDS AND FETAL HOMEOSTASIS
    Maureen Keller Wood; Fiscal Year: 2001
    ..The results of these studies will indicate whether volume homeostasis in the fetus depends on maternal cortisol concentration. ..
  31. Bridges to the Doctorate in Reproductive Biology
    Fuller Bazer; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  32. OVINE INTERFERON-TAU REGULATES UTERINE HORMONE RECEPTOR
    Fuller Bazer; Fiscal Year: 2005
    ....
  33. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2009
    ..a decrease in renal medullary production of 20 HETE 3) To test the hypothesis that abnormalities in renal medullary endothelin production and/or ETB receptor function mediate the hypertension in Dahl salt-sensitive rats ..
  34. Renal Microcirculatory and Tubular Dynamics
    Joey Granger; Fiscal Year: 2004
    ....
  35. Adenosine Signaling and Priapsim
    Yang Xia; Fiscal Year: 2008
    ..By understanding the molecular events involved in the development of priapism, we seek to develop novel therapeutic strategies to treat this disease. [unreadable] [unreadable] [unreadable]..
  36. Nutrition, Fetal Growth, and Placental Angiogenesis
    Lawrence P Reynolds; Fiscal Year: 2010
    ..abstract_text> ..
  37. INTERNAL SENSING SYSTEMS IN HYPOTHALAMUS
    GLENN HATTON; Fiscal Year: 2007
    ..stimulated physiological conditions. Also to be examined are the effects on excitability of simultaneously activating two or more of the receptors that are known to be expressed in the SON. ..
  38. Renal tubular 20-HETE and EETs on sodium retention in
    Mong Heng Wang; Fiscal Year: 2009
    ..abstract_text> ..
  39. Pontomedullary Integration of Respiratory Afferents
    Chi Sang Poon; Fiscal Year: 2010
    ....
  40. Fetal Velocimetry & Amino Acid Transport in Pregnancy
    FREDERICK BATTAGLIA; Fiscal Year: 2007
    ..These studies will establish important links between blood flow changes in the fetus and nutrient delivery to the fetus. ..
  41. Annual Mentoring Program in PsychoNeuroImmunology (PNI) Research
    Christopher Coe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  42. Bisphenol-A and the Reproductive Dysfunction
    Vasantha Padmanabhan; Fiscal Year: 2008
    ..The findings will be relevant to research on fetal origin of infertility and the threat estrogenic environmental disruptors at current exposure levels pose to human health. ..
  43. The Role of Corticotropin-Releasing Factor in Primate Maternal Behavior
    Wendy Saltzman; Fiscal Year: 2007
    ..Ultimately, this research will have implications for the understanding and treatment of stress-related psychopathology in women. [unreadable] [unreadable] [unreadable]..
  44. Mechanisms of Ductus Arteriosus Regulation
    JOHN JEFFREY REESE; Fiscal Year: 2010
    ..These studies will examine new roles for prostaglandins and their relationship with other vasoactive mediators during development. ..
  45. Northeast Under/Grad Research Organization for Neuroscience
    Cheryl Frye; Fiscal Year: 2008
    ..Both of these outcomes are congruous with the Public Health Service's mission to ensure that there is a resource of well-trained scientists and health-care providers in the United States. [unreadable] [unreadable] [unreadable]..
  46. Prenatal and Perinatal Programming of Adult Hypertension
    VESA VEHASKARI; Fiscal Year: 2006
    ..The effect of short-term postnatal dietary and phamacological manipulations on the long-term blood pressure profile will be investigated. ..
  47. MICROMAGNETIC RESONANCE ELASTOGRAPHY
    RICHARD MAGIN; Fiscal Year: 2006
    ....
  48. THE MAJOR ANGIOGENIC FACTORS IN PLACENTAL ANGIOGENESIS
    Lawrence Reynolds; Fiscal Year: 2004
    ..abstract_text> ..
  49. METVAN: A Novel Anticancer Agent
    OSMOND D CRUZ; Fiscal Year: 2003
    ..The knowledge gained from these studies described under Specific Aims 1-2 is expected to facilitate the design of innovative treatment regimens employing METVAN for metastatic breast cancer and brain tumor patients. ..
  50. A 3D C57BL6/J MOUSE BRAIN ATLAS MAGNETIC RESONANCE MICRO
    Helene Benveniste; Fiscal Year: 2003
    ..Further, a probabilistic (averaged from many brain specimens) atlas with error estimations will be created for registration of actual gene-expression data. ..
  51. Magnesium's Antihypertensive Effects in Preeclampsia
    CYNTHIA STANDLEY; Fiscal Year: 2003
    ..Data derived from these experiments will elucidate the anti-hypertensive effects of magnesium, its mode of action and the roles of NO and magnesium in preeclampsia and pregnancy-induced hypertension. ..
  52. DEVELOPMENTAL EXPRESSION OF G-CSF IN THE PLACENTA
    DARLENE CALHOUN; Fiscal Year: 2002
    ....
  53. PHI 346: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Following successful completion of the Phase I in vivo efficacy studies, gel formulation of PHI-346 will be further explored as a vaginal dual-function microbicide in Phase II. ..
  54. Androgenic And Antiandorgenic Interactions Of PC-SPES
    CHARLES ROSELLI; Fiscal Year: 2002
    ..Specific Aim 3: To evaluate the effect of PCSPES on Cytochrome P450-mediated metabolism of androgenic and antiandrogenic drugs by the liver, in order to identify possible interactions of PC-SPES with other hormone therapies. ..
  55. INDICES OF BIOTIN NUTRITION
    Donald Mock; Fiscal Year: 2001
    ..4) Whether biotin deficiency of similar severity to that observed either early or late in human gestation causes increased rates of fetal malformation in the mouse. 5) The enzyme(s) responsible for biotin beta-oxidation. ..
  56. PRENATAL STRESS AND IMMUNE RESPONSIVENESS
    Christopher Coe; Fiscal Year: 2004
    ....
  57. Prenatal Corticosteroid Impact on Hippocampus
    LIBOR VELISEK; Fiscal Year: 2004
    ..The data of this proposal will be critical for determining long-term adverse effects of multiple course prenatal corticosteroid therapy and for the ameliorating these effects in the offspring. ..
  58. HYPOTHALAMIC CONTROL OF PROLACTIN SECRETION
    JAMES VOOGT; Fiscal Year: 2001
    ....
  59. PROSTAGLANDIN SIGNALING IN FEMALE REPRODUCTION
    John Reese; Fiscal Year: 2005
    ..The results of these experiments will enhance the understanding of maternal-fetal PG signaling, and are likely to provide new insights into premature or dysfunctional labor in women. ..
  60. CNS DEVELOPMENT UNDER HYPERGRAVITY : MODULATION BY TH?
    ELIZABETH SAJDEL SULKOWSKA; Fiscal Year: 2004
    ..These studies will aid in developing an understanding of how altered gravity affects CNS development, what role the thyroid hormone plays in that response, and whether this response can be modulated by hormonal therapy. ..
  61. Combinatorial Signals & Gene Expression in Trophoblasts
    Mark Roberson; Fiscal Year: 2006
    ....
  62. Phase II SBIR: WHI-07: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ....
  63. NEUROENDOCRINE CONTROL OF FSH
    Vasantha Padmanabhan; Fiscal Year: 2001
    ....
  64. DETERMINANTS OF REPRODUCTIVE COMPETENCE IN CALLITRICIDS
    Suzette Tardif; Fiscal Year: 2003
    ..Such information can be used to better define long-term captive propagation. The results will also be useful for defining marmosets as models of life history effects on reproduction and maternal health. ..
  65. Mechanisms of Pregnancy Induced Hypertension
    Babbette LaMarca; Fiscal Year: 2007
    ....
  66. Reproductive Consequences of Prenatal Androgenization
    Vasantha Padmanabhan; Fiscal Year: 2005
    ..Specifically it will establish that discrete, experimentally induced androgen excess of fetal sheep provides the first clear etiology for hyperandrogenic anovulation in adulthood. ..
  67. "Post-partum steroid withdrawal-induced depression"
    REBECCA CRAFT; Fiscal Year: 2006
    ..Findings from the proposed model will enhance our understanding of the etiology of PPD and possibly lead to improved treatment options. ..
  68. SAGE Analysis of Murine Oocyte Maturation
    CHARLOTTE FARIN; Fiscal Year: 2004
    ..Differential expression of the candidate gene sequences will be verified using reverse transcription-polymerase chain reaction (RT-PCR). ..
  69. Arginine and Ovine Model for Fetal Growth Restriction
    Guoyao Wu; Fiscal Year: 2007
    ..This will ultimately promote favorable pregnancy outcomes while saving billions of healthcare dollars in the U.S. and worldwide. [unreadable] [unreadable] [unreadable]..