ovulation

Summary

Summary: The discharge of an OVUM from a rupturing Graafian follicle. Ovulation is regulated by a surge release of LUTEINIZING HORMONE.

Top Publications

  1. pmc Novel signaling mechanisms in the ovary during oocyte maturation and ovulation
    Marco Conti
    Center for Reproductive Sciences, Department of Obstetrics and Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, United States
    Mol Cell Endocrinol 356:65-73. 2012
  2. ncbi Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner
    S M Galloway
    AgResearch Molecular Biology Unit, and Centre for Gene Research, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Nat Genet 25:279-83. 2000
  3. ncbi Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries)
    James P Hanrahan
    Teagasc, Research Centre, Athenry, County Galway, Ireland
    Biol Reprod 70:900-9. 2004
  4. ncbi The molecular control of corpus luteum formation, function, and regression
    Carlos Stocco
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, CT 06510, USA
    Endocr Rev 28:117-49. 2007
  5. ncbi Ovulation: new dimensions and new regulators of the inflammatory-like response
    JoAnne S Richards
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Annu Rev Physiol 64:69-92. 2002
  6. pmc The octopamine receptor OAMB mediates ovulation via Ca2+/calmodulin-dependent protein kinase II in the Drosophila oviduct epithelium
    Hyun Gwan Lee
    The Huck Institute Genetics Graduate Program, Pennsylvania State University, University Park, Pennsylvania, USA
    PLoS ONE 4:e4716. 2009
  7. ncbi The link module from ovulation- and inflammation-associated protein TSG-6 changes conformation on hyaluronan binding
    Charles D Blundell
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford, United Kingdom
    J Biol Chem 278:49261-70. 2003
  8. ncbi A new polymorphism in the Growth and Differentiation Factor 9 (GDF9) gene is associated with increased ovulation rate and prolificacy in homozygous sheep
    B D M Silva
    Universidade de Brasilia, Brasilia, Brazil
    Anim Genet 42:89-92. 2011
  9. pmc The impact of ovulation on fallopian tube epithelial cells: evaluating three hypotheses connecting ovulation and serous ovarian cancer
    Shelby M King
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago College of Pharmacy, 900 S Ashland, Chicago, Illinois 60612, USA
    Endocr Relat Cancer 18:627-42. 2011
  10. ncbi Novel signaling pathways that control ovarian follicular development, ovulation, and luteinization
    JoAnne S Richards
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Recent Prog Horm Res 57:195-220. 2002

Detail Information

Publications380 found, 100 shown here

  1. pmc Novel signaling mechanisms in the ovary during oocyte maturation and ovulation
    Marco Conti
    Center for Reproductive Sciences, Department of Obstetrics and Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, United States
    Mol Cell Endocrinol 356:65-73. 2012
    ..This review will provide a summary of the current knowledge of the molecular events triggered by LH focusing mostly on the signaling pathways required for oocyte maturation...
  2. ncbi Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner
    S M Galloway
    AgResearch Molecular Biology Unit, and Centre for Gene Research, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Nat Genet 25:279-83. 2000
    ..The Inverdale (FecXI) sheep, however, carries a naturally occurring X-linked mutation that causes increased ovulation rate and twin and triplet births in heterozygotes (FecXI/FecX+; ref...
  3. ncbi Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries)
    James P Hanrahan
    Teagasc, Research Centre, Athenry, County Galway, Ireland
    Biol Reprod 70:900-9. 2004
    ..The variation in ovulation rate in both breeds is consistent with segregation of a gene (or genes) with a large effect on this trait...
  4. ncbi The molecular control of corpus luteum formation, function, and regression
    Carlos Stocco
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, CT 06510, USA
    Endocr Rev 28:117-49. 2007
    ..The current review highlights our knowledge on these key molecular events in rodents...
  5. ncbi Ovulation: new dimensions and new regulators of the inflammatory-like response
    JoAnne S Richards
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Annu Rev Physiol 64:69-92. 2002
    b>Ovulation is a complex process that is initiated by the lutenizing hormone surge and is controlled by the temporal and spatial expression of specific genes...
  6. pmc The octopamine receptor OAMB mediates ovulation via Ca2+/calmodulin-dependent protein kinase II in the Drosophila oviduct epithelium
    Hyun Gwan Lee
    The Huck Institute Genetics Graduate Program, Pennsylvania State University, University Park, Pennsylvania, USA
    PLoS ONE 4:e4716. 2009
    b>Ovulation is an essential physiological process in sexual reproduction; however, the underlying cellular mechanisms are poorly understood...
  7. ncbi The link module from ovulation- and inflammation-associated protein TSG-6 changes conformation on hyaluronan binding
    Charles D Blundell
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford, United Kingdom
    J Biol Chem 278:49261-70. 2003
    ..The solution structure of the Link module from human TSG-6, a hyaladherin with important roles in inflammation and ovulation, has been determined in both its free and hyaluronan-bound conformations...
  8. ncbi A new polymorphism in the Growth and Differentiation Factor 9 (GDF9) gene is associated with increased ovulation rate and prolificacy in homozygous sheep
    B D M Silva
    Universidade de Brasilia, Brasilia, Brazil
    Anim Genet 42:89-92. 2011
    ..Protein 15 (BMP15) are the first two genes expressed by the oocyte to be associated with an increased ovulation rate in sheep...
  9. pmc The impact of ovulation on fallopian tube epithelial cells: evaluating three hypotheses connecting ovulation and serous ovarian cancer
    Shelby M King
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago College of Pharmacy, 900 S Ashland, Chicago, Illinois 60612, USA
    Endocr Relat Cancer 18:627-42. 2011
    ..Currently, the impact of ovulation on the tubal epithelium is unknown...
  10. ncbi Novel signaling pathways that control ovarian follicular development, ovulation, and luteinization
    JoAnne S Richards
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Recent Prog Horm Res 57:195-220. 2002
    ..interactions of peptide and steroid hormone signaling cascades in the ovary are critical for follicular growth, ovulation, and luteinization...
  11. pmc CCAAT/enhancer-binding proteins (C/EBP)-α and -β are essential for ovulation, luteinization, and the expression of key target genes
    Heng Yu Fan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 25:253-68. 2011
    LH activation of the epidermal growth factor receptor/RAS/ERK1/2 pathway is essential for ovulation and luteinization because granulosa cell (GC) depletion of ERK1/2 (ERK1/2(gc)(-/-) mice) renders mice infertile...
  12. ncbi A novel mutation in the bone morphogenetic protein 15 gene causing defective protein secretion is associated with both increased ovulation rate and sterility in Lacaune sheep
    Loys Bodin
    Institut National de la Recherche Agronomique, UR631, tation d Amélioration Génétique des Animaux, BP 52627, 31326 Castanet Tolosan, France
    Endocrinology 148:393-400. 2007
    Genetic mutations with major effects on ovulation rate and litter size in sheep were recently identified in three genes belonging to the TGFbeta superfamily pathway: the bone morphogenetic protein 15 (BMP15, also known as GDF9b), growth ..
  13. pmc True and sham acupuncture produced similar frequency of ovulation and improved LH to FSH ratios in women with polycystic ovary syndrome
    Lisa M Pastore
    Department of Obstetrics Gynecology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 96:3143-50. 2011
    ..Acupuncture may represent a nonpharmaceutical treatment for women with polycystic ovary syndrome (PCOS), based on four studies...
  14. ncbi The mouse ovarian surface epithelium contains a population of LY6A (SCA-1) expressing progenitor cells that are regulated by ovulation-associated factors
    Lisa F Gamwell
    Center for Cancer Therapeutics, Ottawa Hospital Research Institute, Ontario, Canada
    Biol Reprod 87:80. 2012
    ..a single layer of poorly differentiated epithelial cells, covers the surface of the ovary and is ruptured during ovulation. Little is known about the changes that occur in this layer before or during ovulation, and even less is known ..
  15. ncbi Gene expression profiles of cumulus cell oocyte complexes during ovulation reveal cumulus cells express neuronal and immune-related genes: does this expand their role in the ovulation process?
    Inmaculada Hernandez-Gonzalez
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 20:1300-21. 2006
    b>Ovulation is a complex process initiated by the preovulatory LH surge, characterized by cumulus oocyte complex (COC) expansion and completed by the release of a mature oocyte...
  16. ncbi Kisspeptin synchronizes preovulatory surges in cyclical ewes and causes ovulation in seasonally acyclic ewes
    A Caraty
    Unité Mixte de Recherche 6175, Physiologie de la Reproduction et des Comportements Institut National de la Recherche Agronomique Centre National de la Recherche Scientifique Université Tours Haras Nationaux, 37380, Nouzilly, France
    Endocrinology 148:5258-67. 2007
    We determined whether kisspeptin could be used to manipulate the gonadotropin axis and ovulation in sheep...
  17. ncbi Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells
    T Wilson
    AgResearch Molecular Biology Unit, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Biol Reprod 64:1225-35. 2001
    The Booroola fecundity gene (FecB) increases ovulation rate and litter size in sheep and is inherited as a single autosomal locus. The effect of FecB is additive for ovulation rate (increasing by about 1...
  18. ncbi Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat
    Hisanori Matsui
    Discovery Research Laboratories, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd, Wadai 10, Tsukuba, Ibaraki 300 4293, Japan
    Biochem Biophys Res Commun 320:383-8. 2004
    ..increased the plasma levels of gonadotropins (follicle-stimulating hormone and luteinizing hormone) and induced ovulation in prepubertal female rats that had been pretreated with pregnant mare serum gonadotropin to induce follicle ..
  19. ncbi Time-of-day-dependent changes in GnRH1 neuronal activities and gonadotropin mRNA expression in a daily spawning fish, medaka
    Tomomi Karigo
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Endocrinology 153:3394-404. 2012
    ..From these results, we propose a working hypothesis concerning the temporal regulation of the ovulatory cycle in the brain and pituitary of female medaka...
  20. ncbi Oocyte control of ovarian follicular development and function in mammals
    J J Eppig
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Reproduction 122:829-38. 2001
    ..follicular development, beginning with the initial assembly of the primordial follicle and continuing throughout ovulation. The existence of an oocyte-granulosa cell regulatory loop, essential for normal follicular differentiation as ..
  21. pmc Caenorhabditis elegans FOS-1 and JUN-1 regulate plc-1 expression in the spermatheca to control ovulation
    Susan M Hiatt
    Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, IN 47907, USA
    Mol Biol Cell 20:3888-95. 2009
    ..Here, we provide evidence that C. elegans fos-1 and jun-1 control ovulation, a tightly regulated rhythmic program in animals...
  22. pmc Body weight impact on puberty: effects of high-calorie diet on puberty onset in female rhesus monkeys
    Ei Terasawa
    Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, Wisconsin 53715 1299, USA
    Endocrinology 153:1696-705. 2012
    ..The findings of this study suggest the importance of close monitoring of juvenile feeding behaviors as an important intervention to reduce the prevalence of precocious development and metabolic diseases in adulthood...
  23. ncbi Reproductive phenotpes of the progesterone receptor null mutant mouse
    J P Lydon
    Departement of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Steroid Biochem Mol Biol 56:67-77. 1996
    ....
  24. ncbi Octopamine receptor OAMB is required for ovulation in Drosophila melanogaster
    Hyun Gwan Lee
    Department of Biobehavioral Health and The Huck Institute of Life Sciences, 315 Health and Human Development East, Pennsylvania State University, University Park, PA 16802, USA
    Dev Biol 264:179-90. 2003
    ..The oamb females displayed normal courtship and copulation; however, they were impaired in ovulation with many mature eggs retained in their ovaries...
  25. ncbi Impaired fertility in female mice lacking urinary trypsin inhibitor
    H Sato
    Research Center, Mochida Pharmaceutical Company, Ltd, 722 Jimba aza Uenohara, Shizuoka, Gotemba, 412 8524, Japan
    Biochem Biophys Res Commun 281:1154-60. 2001
    ..These results demonstrate that UTI plays an important role in the formation of the stable cumulus-oocyte complex that is essential for oocyte maturation and ovulation.
  26. ncbi Distinct octopamine cell population residing in the CNS abdominal ganglion controls ovulation in Drosophila melanogaster
    Maria Monastirioti
    Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology Hellas, 71110 Heraklion, Crete, Greece
    Dev Biol 264:38-49. 2003
    ..Here, I show that ovulation process is defective in the mutant females resulting in blockage of mature oocytes within the ovaries...
  27. ncbi Incessant ovulation, inflammation and epithelial ovarian carcinogenesis: revisiting old hypotheses
    Jean S Fleming
    Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Biomedical Sciences, Griffith University Nathan Campus, Nathan, QLD 4111, Australia
    Mol Cell Endocrinol 247:4-21. 2006
    ..The emergence of laser-capture microdissection and expression profiling by microarray technologies offers the promise of defining these pathways more accurately, as well as providing us with the tools for earlier diagnosis...
  28. ncbi Mitochondrial aggregation patterns and activity in porcine oocytes and apoptosis in surrounding cumulus cells depends on the stage of pre-ovulatory maturation
    H Torner
    Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany
    Theriogenology 61:1675-89. 2004
    ..It appears that increased levels of mitochondrial activities in oocytes are correlated to increased levels of apoptosis in surrounding cumulus cells, in which mitochondria may play a role...
  29. pmc Reactive oxygen species are indispensable in ovulation
    Ketty Shkolnik
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 108:1462-7. 2011
    b>Ovulation is stimulated by the preovulatory surge of the pituitary luteinizing hormone (LH)...
  30. ncbi Confirmation of quantitative trait loci using a low-density single nucleotide polymorphism map for twinning and ovulation rate on bovine chromosome 5
    M F Allan
    USDA, ARS, US Meat Animal Research Center, Clay Center, NE 68933, USA
    J Anim Sci 87:46-56. 2009
    ..The US Meat Animal Research Center Production Efficiency Population has 9,186 twinning and 29,571 ovulation rate records for multiple generations of animals, but a significant number of these animals do not have tissue ..
  31. pmc Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses LH-mediated ovulation and luteinization
    Heng Yu Fan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 24:1529-42. 2010
    ..However, the in vivo functions of CTNNB1 during preovulatory follicular development, ovulation, and luteinization remain unclear...
  32. ncbi Structural characterization of PTX3 disulfide bond network and its multimeric status in cumulus matrix organization
    Antonio Inforzato
    Sigma Tau Research and Development, Via Pontina Km 30 400, Pomezia, Italy
    J Biol Chem 283:10147-61. 2008
    ..PTX3 is a key component of the cumulus oophorus extracellular matrix, which forms around the oocyte prior to ovulation, because cumuli from PTX3(-/-) mice show defective matrix organization...
  33. ncbi Prevention of thecal angiogenesis, antral follicular growth, and ovulation in the primate by treatment with vascular endothelial growth factor Trap R1R2
    Christine Wulff
    Medical Research Council, Human Reproductive Sciences Unit, Edinburgh, United Kingdom EH3 9ET
    Endocrinology 143:2797-807. 2002
    ..These results show that VEGF Trap treatment is associated with the suppression of follicular angiogenesis, which results in the inhibition of antral follicular development and ovulation.
  34. ncbi Anti-Müllerian hormone: correlation of early follicular, ovulatory and midluteal levels with ovarian response and cycle outcome in intracytoplasmic sperm injection patients
    Eman A Elgindy
    Department of Obstetrics and Gynecology, Faculty of Medicine, the University of Zagazig, Zagazig, Egypt
    Fertil Steril 89:1670-6. 2008
    ..To measure serum anti-Müllerian hormone (AMH) during different phases of the menstrual cycle and to correlate the measurements with ovarian response and clinical-pregnancy rates in intracytoplasmic sperm injection cycles...
  35. ncbi Oogenesis in teleosts: how eggs are formed
    Esther Lubzens
    Department of Marine Biology, Israel Oceanographic and Limnological Research, 81080 Haifa, Israel
    Gen Comp Endocrinol 165:367-89. 2010
    ..In this review we aim at highlighting recent advances on teleost fish oocyte differentiation, maturation and ovulation, including those involved in the degeneration and reabsorption of ovarian follicles (atresia)...
  36. pmc Two cleavage products of the Drosophila accessory gland protein ovulin can independently induce ovulation
    Yael Heifetz
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 102:743-8. 2005
    ..Here, we show that systemic ectopic expression of ovulin is sufficient to stimulate ovulation in unmated females...
  37. pmc Targeted disruption of Pten in ovarian granulosa cells enhances ovulation and extends the life span of luteal cells
    Heng Yu Fan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 22:2128-40. 2008
    ..novel evidence that Pten impacts the survival/life span of granulosa/luteal cells and that its loss not only results in the facilitated ovulation but also in the persistence of nonsteroidogenic luteal structures in the adult mouse ovary.
  38. ncbi A new era in ovulation induction
    Hananel Holzer
    Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada
    Fertil Steril 85:277-84. 2006
    To evaluate the efficacy of aromatase inhibitors in ovulation induction, superovulation, and IVF.
  39. pmc Liver receptor homolog 1 is essential for ovulation
    Rajesha Duggavathi
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Genes Dev 22:1871-6. 2008
    Female fertility requires normal ovarian follicular growth and ovulation. The nuclear receptor liver receptor homolog 1 has been implicated in processes as diverse as bile acid metabolism, steroidogenesis, and cell proliferation...
  40. pmc Regulation of ovulation rate in mammals: contribution of sheep genetic models
    Stephane Fabre
    INRA, Physiologie de la Reproduction et des Comportements, UMR 6175 INRA CNRS Universite de Tours Haras Nationaux, 37380 Nouzilly, France
    Reprod Biol Endocrinol 4:20. 2006
    Ovarian folliculogenesis in mammals from the constitution of primordial follicles up to ovulation is a reasonably well understood mechanism...
  41. ncbi The oocyte and its role in regulating ovulation rate: a new paradigm in reproductive biology
    K P McNatty
    AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
    Reproduction 128:379-86. 2004
    b>Ovulation rate in mammals is determined by a complex exchange of hormonal signals between the pituitary gland and the ovary and by a localised exchange of hormones within ovarian follicles between the oocyte and its adjacent somatic ..
  42. ncbi In vitro growth and ovulation of follicles from ovaries of estrogen receptor (ER){alpha} and ER{beta} null mice indicate a role for ER{beta} in follicular maturation
    Judith M A Emmen
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences National Institutes of Health, MD B3 02, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 146:2817-26. 2005
    ..In this study, the role of ERalpha and ERbeta in folliculogenesis and ovulation was further analyzed...
  43. ncbi Inositol trisphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. elegans
    T R Clandinin
    Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Cell 92:523-33. 1998
    ..Signals transduced by LET-23 control ovulation through changes in spermathecal dilation, possibly dependent upon calcium release regulated by both IP3 and IP4...
  44. ncbi Roles of the ovarian surface epithelium in ovulation and carcinogenesis
    William J Murdoch
    Reproductive Biology Program, University of Wyoming, Laramie, WY 82071, USA
    Reproduction 123:743-50. 2002
    Although ovarian mechanisms of ovulation have been a subject of investigation for more than a century, essential regulatory pathways remain uncertain. A role for the ovarian surface epithelium in ovulation has recently been demonstrated...
  45. pmc Mouse fertility is enhanced by oocyte-specific loss of core 1-derived O-glycans
    Suzannah A Williams
    Department of Cell Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    FASEB J 22:2273-84. 2008
    ..b>Ovulation of multiple eggs from MOFs was not the reason for increased fertility based on ovulated egg and corpora lutea ..
  46. pmc Reduction in ovulation or male sex phenotype increases long-term anoxia survival in a daf-16-independent manner in Caenorhabditis elegans
    Alexander R Mendenhall
    Department of Biological Sciences, University of North Texas, Denton, Texas 76203, USA
    Physiol Genomics 36:167-78. 2009
    ..except in the case of sterile hermaphrodites [spe-9(hc52ts), fer-15(hc15ts)] undergoing oocyte maturation and ovulation as exhibited by the presence of laid unfertilized oocytes...
  47. ncbi Daily low-dose mifepristone has contraceptive potential by suppressing ovulation and menstruation: a double-blind randomized control trial of 2 and 5 mg per day for 120 days
    Audrey Brown
    Contraceptive Development Network, Centre for Reproductive Biology, University of Edinburgh, Edinburgh, EH3 9ET, United Kingdom
    J Clin Endocrinol Metab 87:63-70. 2002
    Daily administration of progesterone (P) antagonists to women inhibits ovulation and disrupts endometrial function...
  48. ncbi DNA tests in prolific sheep from eight countries provide new evidence on origin of the Booroola (FecB) mutation
    George H Davis
    Invermay Agricultural Centre, Mosgiel, New Zealand
    Biol Reprod 66:1869-74. 2002
    ..The DNA mutation test for FecB will enable breeding plans to be developed that allow the most effective use of this gene in Garole and Javanese Thin-tailed sheep and their crosses...
  49. ncbi Effects of insemination-ovulation interval on fertilization rates and embryo characteristics in dairy cattle
    J B Roelofs
    Adaptation Physiology Group, Wageningen University, P O Box 338, 6700 AH Wageningen, The Netherlands
    Theriogenology 66:2173-81. 2006
    The objective of this study was to examine effects of the interval between insemination and ovulation on fertilization and embryo characteristics (quality scored as good, fair, poor and degenerate; morphology; number of cell cycles and ..
  50. ncbi Endotoxin induces delayed ovulation following endocrine aberration during the proestrous phase in Holstein heifers
    C Suzuki
    National Institute of Animal Health, Laboratory of Theriogenology, 3 1 5 Kannondai, Tsukuba, 305 0856, Ibaraki, Japan
    Domest Anim Endocrinol 20:267-78. 2001
    ..Holstein heifers were treated with PGF2alpha at 11-13 d after ovulation to induce luteolysis...
  51. pmc Segregation of a major gene influencing ovulation in progeny of Lacaune meat sheep
    Loys Bodin
    Station d Amélioration Génétique des Animaux, Institut National de la Recherche Agronomique, BP 27, 31326 Castanet Tolosan, France
    Genet Sel Evol 34:447-64. 2002
    Inheritance of the ovulation rate (OR) in the Lacaune meat breed was studied through records from a small nucleus of 36 hyper-prolific ewes screened on farms on the basis of their natural litter size, and from progeny data of three ..
  52. ncbi Fine mapping of the FecL locus influencing prolificacy in Lacaune sheep
    L Drouilhet
    UMR INRA ENVT, Laboratoire de Genetique Cellulaire, BP 52627, 31326 Castanet Tolosan, France
    Anim Genet 40:804-12. 2009
    In the Lacaune sheep population, two major loci influencing ovulation rate are segregating: FecX and FecL. The FecX(L) mutation is a non-conservative substitution (p.Cys53Tyr) in BMP15 that prevents the processing of the protein...
  53. ncbi Molecular mechanisms of ovulation: co-ordination through the cumulus complex
    Darryl L Russell
    Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, The University of Adelaide, Adelaide, South Australia, Australia
    Hum Reprod Update 13:289-312. 2007
    Successful ovulation requires that developmentally competent oocytes are released with appropriate timing from the ovarian follicle...
  54. pmc Large P body-like RNPs form in C. elegans oocytes in response to arrested ovulation, heat shock, osmotic stress, and anoxia and are regulated by the major sperm protein pathway
    Molly C Jud
    Central Michigan University, Department of Biology, 193 Brooks Hall, Mount Pleasant, MI 48859, USA
    Dev Biol 318:38-51. 2008
    As Caenorhabditis elegans hermaphrodites age, sperm become depleted, ovulation arrests, and oocytes accumulate in the gonad arm...
  55. pmc Drosophila seminal protein ovulin mediates ovulation through female octopamine neuronal signaling
    C Dustin Rubinstein
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853 2703
    Proc Natl Acad Sci U S A 110:17420-5. 2013
    ..To investigate this topic, we studied the increase in Drosophila melanogaster ovulation behavior induced by mating...
  56. pmc Vocal cues of ovulation in human females
    Gregory A Bryant
    Department of Communication Studies, Center for Behavior, Evolution and Culture, University of California, Los Angeles, CA 90095 1563, USA
    Biol Lett 5:12-5. 2009
    ..the follicular (high-fertility) phase of the cycle and one set during the luteal (low-fertility) phase, with ovulation confirmed by luteinizing hormone tests...
  57. ncbi Invited review: Treatment of cows with an extended postpartum anestrous interval
    F M Rhodes
    Dexcel Limited, Private Bag 3221, Hamilton, New Zealand
    J Dairy Sci 86:1876-94. 2003
    Cows with an extended interval from calving to first ovulation (PPI) have increased intervals from calving to conception and are more likely to be culled compared with cows with a short PPI...
  58. ncbi Genetic control of multiple births in low ovulating mammalian species
    Aurélie Vinet
    INRA, UMR1313 Genetique Animale et Biologie Integrative, 78352, Jouy en Josas Cedex, France
    Mamm Genome 23:727-40. 2012
    ..mammalian species, with particular focus on three species: sheep, cattle, and humans, where knowledge of the ovulation rate in one may enlighten findings in the others...
  59. ncbi Are BMP-15 and GDF-9 primary determinants of ovulation quota in mammals?
    R Kelly Moore
    Department of Reproductive Medicine, University of California San Diego, School of Medicine, La Jolla, CA 92093 0633, USA
    Trends Endocrinol Metab 15:356-61. 2004
    ..has grown in recent years as a result of intense efforts to identify and characterize the genes that control the ovulation quota...
  60. pmc Ovarian furin (proprotein convertase subtilisin/kexin type3): expression, localization, and potential role in ovulation in the rat
    Brian P Kelty
    Department of Obstetrics and Gynecology, Chandler Medical Center, University of Kentucky, 800 Rose Street, Lexington, KY 40536, USA
    Biol Reprod 83:147-54. 2010
    The process of ovulation involves weakening of the follicular wall by proteolytic enzymes. The function of FURIN (also known as PCSK3) is to activate various proteolytic enzymes...
  61. ncbi A new method for estimating the effectiveness of emergency contraception that accounts for variation in timing of ovulation and previous cycle length
    Rafael T Mikolajczyk
    Department of Public Health Medicine, School of Public Health, University of Bielefeld, Bielefeld, Germany
    Fertil Steril 83:1764-70. 2005
    ..of emergency contraception (EC) by using information about previous menstrual cycle length, accounting for the variation in the day of ovulation within the menstrual cycle, and comparing the validity of the new and previous methods.
  62. pmc emo-1, a Caenorhabditis elegans Sec61p gamma homologue, is required for oocyte development and ovulation
    K Iwasaki
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 134:699-714. 1996
    ..Oocytes in emo-1(oz1) mutants exhibit multiple defects during oogenesis. After meiotic maturation, ovulation fails, trapping oocytes in the gonad arm where they become endomitotic...
  63. ncbi Return of ovulation and menses in postpartum nonlactating women: a systematic review
    Emily Jackson
    World Health Organization, Geneva, Switzerland
    Obstet Gynecol 117:657-62. 2011
    ..To estimate, from the literature, when nonlactating postpartum women regain fertility...
  64. ncbi GnRH agonist ovulation trigger and hCG-based, progesterone-free luteal support: a proof of concept study
    Shahar Kol
    Department of Obstetrics and Gynecology, IVF Unit, Rambam Health Care Campus, Haifa, Israel
    Hum Reprod 26:2874-7. 2011
    It is now well established that a GnRH agonist (GnRHa) ovulation trigger completely prevents ovarian hyperstimulation syndrome...
  65. pmc Melatonin reduces LH, 17 beta-estradiol and induces differential regulation of sex steroid receptors in reproductive tissues during rat ovulation
    Luiz Gustavo A Chuffa
    Department of Structural and Cellular Biology, Institute of Biology, Universidade Estadual de Campinas UNICAMP, Campinas SP 13083 863, Brazil
    Reprod Biol Endocrinol 9:108. 2011
    ..However, its effects on sex hormones and steroid receptors during ovulation are not clearly defined...
  66. ncbi Early onset of obesity induces reproductive deficits in female rats
    Sara C Sagae
    Centro de Ciencias Biologicas e da Saude, Universidade Estadual do Oeste do Paraná UNIOESTE, Cascavel, PR, Brazil
    Physiol Behav 105:1104-11. 2012
    ..parameters, including estradiol, progesterone, LH and prolactin during the proestrus afternoon, sexual behavior, ovulation rates and histological analysis of ovaries were also evaluated...
  67. ncbi Diversification of cyclooxygenase-2-derived prostaglandins in ovulation and implantation
    H Matsumoto
    Department of Molecular and Integrative Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas 66160 7338, USA
    Biol Reprod 64:1557-65. 2001
    Previous observations of ovulation and fertilization defects in cyclooxygenase-2 (COX-2)-deficient mice suggested that COX-2-derived ovarian prostaglandins (PGs) participate in these events...
  68. pmc Control of ovulation in mice by progesterone receptor-regulated gene networks
    Jaeyeon Kim
    Department of Molecular and Integrative Physiology, Center for Research in Reproduction and Infertility, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Mol Hum Reprod 15:821-8. 2009
    The mid-cycle surge of luteinizing hormone (LH) induces ovulation, a process during which a fertilizable oocyte is released from a mature ovarian follicle...
  69. ncbi Phospholipase Cepsilon regulates ovulation in Caenorhabditis elegans
    Ken Ichi Kariya
    Division of Cell Biology, Graduate School of Medicine, University of the Ryukyus, Nishihara cho, Okinawa 903 0215, Japan
    Dev Biol 274:201-10. 2004
    ..b>Ovulation in C...
  70. ncbi Female sexual swelling size, timing of ovulation, and male behavior in wild West African chimpanzees
    Tobias Deschner
    Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
    Horm Behav 46:204-15. 2004
    ..measures (from video captures) of female sexual swellings with (ii) urinary hormone data to indicate timing of ovulation through enzyme immunoassay measurements of estrone conjugates and pregnanediol glucuronide (PdG) and (iii) ..
  71. ncbi Phenotypic association of spontaneous ovulation and sexual receptivity in virgin females of Drosophila melanogaster mutants
    A Ejima
    Department of Biological Sciences, Tokyo Metropolitan University, Hachioji-shi, Japan
    Behav Genet 31:437-44. 2001
    In Drosophila melanogaster females, mating stimulates ovulation/oviposition and switches off receptivity...
  72. pmc Ionotropic glutamate receptor AMPA 1 is associated with ovulation rate
    Mayumi Sugimoto
    National Livestock Breeding Center, Nishigo, Japan
    PLoS ONE 5:e13817. 2010
    ..and anterior pituitary hormone secretion, there is a limited understanding of how glutamate receptors control ovulation. Here we reveal the function of the ionotropic glutamate receptor AMPA-1 (GRIA1) in ovulation...
  73. ncbi Sperm binding properties and secretory activity of the bovine oviduct immediately before and after ovulation
    Edita Sostaric
    Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Mol Reprod Dev 75:60-74. 2008
    The possibility that differences in hormonal regimes between the two oviducts in the cow around ovulation affects secretory activity of the oviduct epithelial cells and/or sperm-oviduct binding was studied...
  74. ncbi Number of fetuses and conceptus growth throughout gestation in lines of pigs selected for ovulation rate or uterine capacity
    B A Freking
    USDA, ARS, US Meat Animal Research Center, Clay Center, NE 68933 0166, USA
    J Anim Sci 85:2093-103. 2007
    Selection for 11 generations in swine for ovulation rate (OR) or uterine capacity (UC) resulted in 19.6% greater prenatal survival at term in UC compared with OR...
  75. ncbi In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,4,7,8-pentachlorodibenzofuran reduces growth and disrupts reproductive parameters in female rats
    Travis B Salisbury
    Department of Biological Sciences, Kent State University, Kent, Ohio 44242, USA
    Biol Reprod 66:1621-6. 2002
    ..effects of in utero and lactational (IUL) exposure to TCDD and PCDF on subsequent growth, estrous cycles, and ovulation. Additionally a gonadotropin-primed immature rat model was used to investigate possible direct effects on the ..
  76. ncbi A diet rich in n-3 polyunsaturated fatty acids reduced prostaglandin biosynthesis, ovulation rate, and litter size in mice
    D Yi
    State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China
    Theriogenology 78:28-38. 2012
    ..effects of dietary supplementation of fish oil (rich in n-3PUFAs; N3) or CLA on PGE(2) and PGF(2α) production, ovulation rate, and litter size, using female transgenerational mice as an experimental model...
  77. ncbi Low expression of COX-2, reduced cumulus expansion, and impaired ovulation in SULT1E1-deficient mice
    Eran Gershon
    Department of Biological Regulation, Weizmann Institute of Science, P O B 26, Rehovot 76100, Israel
    FASEB J 21:1893-901. 2007
    ..that, in addition to placental dysfunction, this phenotype demonstrates that an excess of estrogen impairs ovulation. The role of SULT1E1 in ovulation is suggested by the substantially low ovulatory response in hCG-treated ..
  78. ncbi Inhibition of ovulation by NOMAC/E2, a novel monophasic oral contraceptive combining nomegestrol acetate and 17β-oestradiol: a double-blind, randomised, dose-finding pilot study
    Nathalie Chabbert-Buffet
    Obstetrics and Gynaecology Unit, Hopital Tenon AP HP, and ER 9, UPMC Universite Paris 06, Paris, France
    Eur J Contracept Reprod Health Care 16:76-84. 2011
    To explore the optimal dose of the progestogen, nomegestrol acetate (NOMAC), required in a monophasic oral contraceptive, in combination with 1.5 mg 17β-oestradiol (E(2)), to inhibit ovulation.
  79. ncbi Identification of perilipin-2 as a lipid droplet protein regulated in oocytes during maturation
    Xing Yang
    the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong Province, 510080, China
    Reprod Fertil Dev 22:1262-71. 2010
    ..Thus, perilipin-2 is a lipid droplet protein in oocytes and its induction in the COC concurrent with dynamic reorganisation of lipid droplets suggests marked changes in lipid utilisation during oocyte maturation...
  80. ncbi Ultrastructural dynamics of human reproduction, from ovulation to fertilization and early embryo development
    Giuseppe Familiari
    Laboratory of Electron Microscopy, Pietro M Motta Department of Anatomy, University of Rome, La Sapienza, 00161 Rome, Italy
    Int Rev Cytol 249:53-141. 2006
    ....
  81. pmc Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Mérino ewes
    P Mulsant
    Institut National de la Recherche Agronomique, Laboratoire de Genetique Cellulaire, BP, 27, 31326 Castanet Tolosan, France
    Proc Natl Acad Sci U S A 98:5104-9. 2001
    Ewes from the Booroola strain of Australian Mérino sheep are characterized by high ovulation rate and litter size...
  82. pmc Effects of deletion of the prolactin receptor on ovarian gene expression
    Isabelle Grosdemouge
    Molecular Endocrinology, INSERM U344 Faculté de Médecine Necker Enfants Malades, 75730 Paris Cedex 15, France
    Reprod Biol Endocrinol 1:12. 2003
    ..The present study demonstrates that the ovulation rate is not different between PRLR+/+ and PRLR-/- mice...
  83. ncbi Patterns of anogenital swelling size and their endocrine correlates during ovulatory cycles and early pregnancy in free-ranging barbary macaques (Macaca sylvanus) of Gibraltar
    U Möhle
    Department of Reproductive Biology, German Primate Centre, Goettingen, Germany
    Am J Primatol 66:351-68. 2005
    ..the early to the late follicular phase, in association with an elevated estrogen:progestagen (E:P) ratio, with ovulation occurring during the maximum swelling phase...
  84. ncbi Age, size, and spatiotemporal variation in ovulation patterns of a seasonal breeder, the Norwegian moose (Alces alces)
    Mathieu Garel
    Universite de Lyon, Centre National de Recherche Scientifique, Unite Mixte de Recherche 5558, Laboratoire de Biometrie et Biologie Evolutive, 43 Boulevard du 11 Novembre 1918, Villeurbanne F 69622, France
    Am Nat 173:89-104. 2009
    ..Here we analyze how age and body mass affect spatiotemporal variation in timing of ovulation of 6,178 Norwegian moose...
  85. ncbi Estimation of the day-specific probabilities of conception: current state of the knowledge and the relevance for epidemiological research
    Courtney D Lynch
    Epidemiology Branch, Division of Epidemiology Statistics and Prevention Research, National Institute of Child Health and Human Development, NIH, Department of Health and Human Services, Rockville, MD 20852, USA
    Paediatr Perinat Epidemiol 20:3-12. 2006
    ..Currently, a biomarker of conception is not available; as conception occurs shortly after ovulation, the latter can be used as a proxy for the time of conception...
  86. ncbi Relationship between maternal endocrine environment, early embryo development and inhibition of the luteolytic mechanism in cows
    G E Mann
    University of Nottingham, School of Biosciences, Division of Animal Physiology, Sutton Bonington, Loughborough LE12 5RD, UK
    Reproduction 121:175-80. 2001
    ..Inseminated cows without an embryo on day 16 (n = 5) underwent both delayed ovulation (indicated by delayed decrease in oestradiol concentrations) and a delayed increase in progesterone ..
  87. pmc Women's sexual interests across the ovulatory cycle depend on primary partner developmental instability
    Steven W Gangestad
    Department of Psychology, University of New Mexico, Albuquerque, NM 87111, USA
    Proc Biol Sci 272:2023-7. 2005
    ..women have been found to report greater sexual attraction to men other than their own partners when near ovulation relative to the luteal phase...
  88. ncbi Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation
    Naresh Kumar Hanchate
    INSERM, Jean Pierre Aubert Research Center, U837, Development and Plasticity of the Postnatal Brain, Institut Fédératif de Recherche 114, France
    J Neurosci 32:932-45. 2012
    ..Various permissive homeostatic signals must be integrated to achieve ovulation in mammals...
  89. ncbi ADAMTS1 cleavage of versican mediates essential structural remodeling of the ovarian follicle and cumulus-oocyte matrix during ovulation in mice
    Hannah M Brown
    School of Paediatrics and Reproductive Health, Robinson Institute, The University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 83:549-57. 2010
    Remodeling of ovarian follicle extracellular matrix is essential for ovulation and vascularization of the corpus luteum (CL)...
  90. ncbi Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries: a randomized, double-blinded placebo-controlled trial
    E H Ng
    Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People s Republic of China
    Hum Reprod 16:1625-31. 2001
    Metformin, an insulin-sensitizing agent, has been used successfully as the first-line drug to induce ovulation in women with polycystic ovary syndrome...
  91. ncbi Repeat breeding in dairy heifers: follicular dynamics and estrous cycle characteristics in relation to sexual hormone patterns
    R Båge
    Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Center for Reproductive Biology in Uppsala, Swedish University of Agricultural Sciences
    Theriogenology 57:2257-69. 2002
    ..seems to be the underlying cause for a series of dysfunctions such as prolonged standing estrus and delayed ovulation, leading to fertilization failure...
  92. ncbi Endometriotic ovarian cysts negatively affect the rate of spontaneous ovulation
    Laura Benaglia
    Infertility Unit, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via M Fanti 6, 20122 Milan, Italy
    Hum Reprod 24:2183-6. 2009
    ..To clarify this aspect, we set up a prospective study in women with monolateral endometriomas in order to assess the rate of ovulation in affected ovaries.
  93. ncbi Influences of age and ovarian follicular reserve on estrous cycle patterns, ovulation, and hormone secretion in the Long-Evans rat
    C R Anzalone
    Department of Biology, University of California, Los Angeles 90095, USA
    Biol Reprod 64:1056-62. 2001
    ..Similarly, ovulation rates were highest in young controls, intermediate in young ULO rats and MA controls, and lowest in MA ULO ..
  94. ncbi Contraceptive efficacy of emergency contraception with levonorgestrel given before or after ovulation
    Gabriela Noe
    Instituto Chileno de Medicina Reproductiva ICMER, Santiago, Chile
    Contraception 81:414-20. 2010
    We aimed to evaluate whether emergency contraception with levonorgestrel (LNG-EC) administered after ovulation is equally effective to LNG-EC administered before ovulation.
  95. ncbi Scent of a woman: men's testosterone responses to olfactory ovulation cues
    Saul L Miller
    Department of Psychology, Florida State University, Tallahassee, FL 32306 4301, USA
    Psychol Sci 21:276-83. 2010
    ..In line with this framework, the current studies examined the extent to which olfactory cues to female ovulation--scents of women at the peak of their reproductive fertility--influence endocrinological responses in men...
  96. ncbi Letrozole versus clomiphene citrate: which is better for ovulation induction?
    Robert F Casper
    Professor, Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Canada
    Fertil Steril 92:858-9. 2009
    Letrozole is at least as effective as clomiphene for inducing ovulation and achieving pregnancy in patients with polycystic ovarian syndrome...
  97. ncbi Growth differentiation factor 9 and bone morphogenetic protein 15 are essential for ovarian follicular development in sheep
    Jennifer L Juengel
    AgResearch Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Biol Reprod 67:1777-89. 2002
    ..BMP15; also known as GDF9B) are essential for normal ovarian follicular development in mammals with a low ovulation rate phenotype...
  98. pmc Endometriosis and infertility: a multi-cytokine imbalance versus ovulation, fertilization and early embryo development
    S Vassiliadis
    Department of Biology, University of Crete, Heraklion, Crete, Greece
    Clin Dev Immunol 12:125-9. 2005
    ..In this commentary, going through the cytokine requirement during ovulation, fertilization and the early stages of pregnancy, it became possible to specifically define the harmful ..
  99. ncbi Morphological analyses of interleukin-8 effects on rat ovarian follicles at ovulation and luteinization in vivo
    Junko Goto
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Cytokine 20:168-73. 2002
    The aim of the present study was to elucidate functions of the interleukin (IL)-8 at ovulation and luteinization in vivo...
  100. pmc Loss of oestrus, concealed ovulation and paternity confusion in free-ranging Hanuman langurs
    M Heistermann
    Department of Reproductive Biology, German Primate Centre, Kellnerweg 4, 37077 Gottingen, Germany
    Proc Biol Sci 268:2445-51. 2001
    ..catarrhine primates are uniquely characterized by prolonged periods of sexual activity in which the timings of ovulation and copulation do not necessarily correspond...
  101. ncbi The water permeability channels aquaporins 1-4 are differentially expressed in granulosa and theca cells of the preovulatory follicle during precise stages of human ovulation
    Asgeir Thoroddsen
    Department of Obstetrics and Gynaecology, Sahlgrenska Academy, University of Gothenburg, SE 413 45 Goteborg, Sweden
    J Clin Endocrinol Metab 96:1021-8. 2011
    ..Changes in vascular permeability and expansion of the fluid-filled antrum are major events in the LH-induced ovulatory process...

Research Grants70

  1. Physiology of Hypothalamic Neurosteroidal Progesterone
    Paul E Micevych; Fiscal Year: 2013
    ..The LH surge triggers ovulation and the luteinization of the ruptured follicle - critical events in reproduction...
  2. Epigenetic effects of developmental endocrine disruptor exposure in the ovary
    Mehmet Uzumcu; Fiscal Year: 2010
    ..exposure to MXC alters gene expression in the ovary, leading to inhibition of follicular maturation and the ovulation, which are associated with gene-specific [(e.g...
  3. Analysis of the role of the VRK1 protein kinase in mammalian fertility
    Paula Traktman; Fiscal Year: 2011
    ..to the defect in males, preliminary histological analyses reveal that maturation of ovarian follicles and ovulation proceed normally in VRK-deficient mice...
  4. Transcriptional control of pituitary gonadotropin genes
    Varykina G Thackray; Fiscal Year: 2013
    ..Production of gonadotropin hormones critical for steroidogenesis, gametogenesis and ovulation is also disturbed in these disorders...
  5. Vitamin D3 Regulation of the Hypothalamic-Pituitary-Gonadal Axis
    Genevieve S Neal-Perry; Fiscal Year: 2012
    ..Our preliminary data show that gonadotropins stimulate follicular development and ovulation, but that puberty and the first estrus are delayed in vitamin D3 deficient CYP27b1 null female mice and that ..
  6. Outcomes of Infertility Treatments in Clinic and Population-Based Cohorts
    Joseph B Stanford; Fiscal Year: 2010
    ..Infertility treatments range from less invasive medical treatments (including ovulation induction and artificial insemination) to assisted reproductive technologies (ART), which complete early stages ..
  7. Environmental regulation of estrogen dependent aggression
    Brian C Trainor; Fiscal Year: 2013
    ..For example, at ovulation estrogens switch from exerting negative feedback on gonadotropin releasing hormone to exerting positive feedback...
  8. Progesterone's Role in Pubertal Maturation in Normal and Hyperandrogenemic Adoles
    JESSICAH S P COLLINS; Fiscal Year: 2011
    ..Polycystic ovary syndrome (PCOS) is a common hormonal disorder marked by elevated male hormone levels, impaired ovulation and cysts on the ovaries that causes significant morbidity in adult women, including abnormal hair growth, acne, ..
  9. Treatment of Hyperandrogenism vs. Insulin Resistance in Infertile PCOS Women
    Richard S Legro; Fiscal Year: 2012
    ..This will be followed by ovulation induction with clomiphene citrate in all subjects for up to 4 cycles (Phase II)...
  10. Regulation and Function of the Rhox8 homeobox gene in granulosa cells
    JAMES ARTHUR MACLEAN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Ovulation is a complex and intriguing biological process that is essential for mammalian reproduction. The actions of granulosa cells in the ovary are central to successful ovulation...
  11. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard L Stouffer; Fiscal Year: 2013
    ..out steroid effects via the hypothalamic-pituitary axis: (1) during the periovulatory interval (controlled ovulation), or (2) during mid-to-late luteal phase (controlled luteal function)...
  12. Leukemia Inhibitory Factor As a Mediator of Primate Ovulation &Oocyte Maturation
    Jon D Hennebold; Fiscal Year: 2013
    ..and molecular processes occurring within the primate follicle resulting in the release of a mature ovum (ovulation) that fertilizes and undergoes subsequent embryonic development are incompletely defined...
  13. Role of Fetal Steroids in Formation and Activation of Bovine Ovarian Follicles
    Joanne E Fortune; Fiscal Year: 2010
    ..since this stockpile of follicles is used through the female's reproductive life as a source of oocytes for ovulation, it is critical for reproductive success and also a potential target for fertility enhancement or contraception...
  14. Regulation and Function of Germline RNP Granules
    JENNIFER SCHISA; Fiscal Year: 2010
    ..RNAi screen to identify genes required for the MEX-3 RNA-binding protein to assemble into large granules when ovulation is arrested...
  15. REGULATION OF OVARIAN FUNCTION BY GONADOTROPIN
    JAIRAM K M MENON; Fiscal Year: 2013
    ..LH, through its interaction with LH/hCG receptor (LHR) regulates steroid hormone production, ovulation, fertilization, implantation and pregnancy maintenance...
  16. DEVELOPMENT OF MAMMALIAN OOCYTE-GRANULOSA CELL COMPLEX
    John J Eppig; Fiscal Year: 2012
    ..of oocyte and follicular development are essential for the development of oocytes, oocyte maturation, and timely ovulation in a condition optimal for fertilization subsequent embryogenesis...
  17. Anxiety Sensitivity, Menstrual Cycle Phase, and Panic-Relevant Responding
    Yael Nillni; Fiscal Year: 2011
    ..Cycle phase will be estimated by day count and ovulation kits and confirmed via progesterone assay...
  18. Physiological Mechanisms Underlying Heightened Responsiveness of Gonadotropes to
    Colin M Clay; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ovulation is one of the most fundamental events in reproduction and requires a dramatic surge of luteinizing hormone (LH) released by the anterior pituitary gland into the peripheral circulation...
  19. Estrogen Modulation of Bursting Activity in GnRH Neurons
    Oline K Ronnekleiv; Fiscal Year: 2013
    ..hypothalamus and constitute the final step in the regulation of pituitary luteinizing hormone (LH) secretion and ovulation in females...
  20. DETERMINANTS OF MALE AND FEMALE FECUNDITY AND FERTILITY-DATA COORDINATING CENTER
    Edward Clark; Fiscal Year: 2009
    ..Women were instructed in the use of home fertility monitors and pregnancy kits to determine ovulation (screening for estradiol and LH) and hCG-confirmed pregnancies...
  21. Protease regulation of ovarian recrudescence
    KELLY ANSLEY YOUNG; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ovarian function, including follicle development, ovulation, and corpus luteum formation/degradation, is dependent upon tissue remodeling events, many of which are associated with a family of Zn+..
  22. The Utility of Empiric Medical Treatment of Infertile Oligo-asthenospermic Men
    Peter R Casson; Fiscal Year: 2013
    ..We hypothesize that when used in conjunction with controlled ovulation induction (COI)/intrauterine insemination (lUl), EMT represents effective therapy...
  23. Central actions of estrogens: Effects of GnRH neurons
    Suzanne M Moenter; Fiscal Year: 2013
    ..In females, understanding the control of ovulation is critical for helping those with infertility conceive singe, as opposed to multiple, births, and for ..
  24. Pubertal hyperandrogenemia, modification of day-night GnRH secretion, and PCOS
    Christopher R McCartney; Fiscal Year: 2012
    ..follicle- stimulating hormone (FSH) secretion, which in turn contribute to androgen excess and irregular ovulation. This defect is in part related to excess T, which interferes with the ability of progesterone (P) to suppress ..
  25. Circadian Regulation of Gonadotropin-Releasing Hormone
    Patrick E Chappell; Fiscal Year: 2010
    ..reproduction depends on pulsatile secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus, and ovulation in females requires a robust surge of GnRH...
  26. A Novel Function of the Oocyte in Estrogen-Regulated FSH Action
    Shunichi Shimasaki; Fiscal Year: 2009
    ..hormone (FSH) is an essential hormone for the ovarian function that includes follicle development and ovulation. We have recently discovered that estrogen enhances FSH action in follicular cells in the presence, but not ..
  27. OVARIAN HORMONE REGULATION OF LHRH BIOSYNTHESIS
    Sandra L Petersen; Fiscal Year: 2010
    ..how ovarian steroids trigger luteinizing hormone-releasing hormone (LHRH) and LH surge release, thereby inducing ovulation. In these studies, we will investigate mechanisms through which potoperiod and estrogen signals interact to ..
  28. Molecular Mechanisms of Meiotic Maturation in Drosophila
    Daniela Drummond-Barbosa; Fiscal Year: 2013
    ..After meiotic maturation, oocytes arrest again in metaphase I until ovulation. In the prior funding period, we demonstrated that 1-Endosulfine (Endos) is required for meiotic maturation...
  29. The role of Core Binding Factors (CBFs) in the periovulatory process
    Misung Jo; Fiscal Year: 2011
    ..The preovulatory gonadotropin surge initiates the final process of follicular maturation that culminates in ovulation of an expanded cumulus-oocyte complex (COC) and formation of the corpus luteum (CL)...
  30. Influence of Endocrine Disruptors on Reproductive Neuroendocrine Function
    JOSEPH RAYMOND KURIAN; Fiscal Year: 2013
    ..Typical release patterns govern gamete maturation, ovulation, steroid hormone secretion and maintenance of luteal function...
  31. MicroRNA Regulation of Ovarian Function
    Lane K Christenson; Fiscal Year: 2013
    ..b>Ovulation of a fertilizable oocyte and formation of a functional corpus luteum are absolute requirements for reproductive ..
  32. Prostaglandins in C. elegans Fertilization
    Michael A Miller; Fiscal Year: 2013
    ..Prostaglandins are essential for ovulation and fertilization, but the molecular mechanisms are not well understood...
  33. Regulation of Sister-Chromatid Cohesion in Drosophila Meiosis
    SHARON ELIZABETH BICKEL; Fiscal Year: 2013
    ..recombination during fetal development and remain suspended in a prolonged dictyate (diplotene) arrest until ovulation, the continuous association of homologous chromosomes demands that meiotic sister-chromatid cohesion be ..
  34. Ovarian Androgen Production and Control of Follicular Funtion
    K M JAIRAM MENON; Fiscal Year: 2010
    ..cells and the destructive effect these androgens produce in preparing the ovarian follicles for ovulation. The results will have direct bearing on the understanding of the pathophysiology of androgen excess disorders ..
  35. The Inositol Phosphate Cascade as a Regulator of FSH and LH actions in the Ovary
    Shawn M Breen; Fiscal Year: 2012
    ..inositol phosphate cascade by LHR is necessary for down regulation of aromatase expression that occurs after ovulation. Aim 1 will generate a mouse model with a granulosa cell- specific deletion of the Gq/11-sensitive inositol ..
  36. Prevention of Menopause-Related Ovarian Epithelial Cancer
    Elizabeth R Smith; Fiscal Year: 2010
    ..The risk of epithelial ovarian cancer is well linked with reproductive history, where uninterrupted ovulation frequency and non-parity increase the risk, and parity and the use of oral contraceptives clearly reduce the ..
  37. Investigation of calcium signaling in Caenorhabditis elegans
    Kenneth Norman; Fiscal Year: 2013
    ..These rhythmic behaviors include pharyngeal pumping, ovulation and fertilization, and defecation...
  38. Improving Primordial Follicle Survival After Transplantation of Cryopreserved Hum
    Kutluk H Oktay; Fiscal Year: 2012
    ..and compared between S1P treated and control grafts by analysis of follicle and oocyte morphology, oocyte maturation and ovulation rates in response to hCG administration, steroid hormone production, as well as parthenogenic activation.
  39. Role of Leptin in the Neuroendocrine Response to Fasting
    Christos S Mantzoros; Fiscal Year: 2011
    ..leptin replacement to correct the relative leptin deficiency in women with HA resulted in follicular growth and ovulation and significantly improved hormone levels, providing preliminary evidence that leptin may contribute to the ..
  40. A Pooled Analysis to Identify New Ovarian Cancer Risk Factors
    Celeste Leigh Pearce; Fiscal Year: 2010
    ..pregnancy, both of which create higher than normal exposure to progestins, decrease risk is not through blocking ovulation, but rather through the increased progestin exposure...
  41. Efficacy of Dexamethasone in Polycystic Ovary Syndrome Related Infertility
    Randal Robinson; Fiscal Year: 2013
    ..between serum hormone levels and markers of Inflammation or treatment-related changes In these parameters and ovulation and live born delivery rates...
  42. The role of chemokines in cumulus oocyte expansion (C-OE) and oocyte maturation
    MARINA CINTHIA PELUFFO; Fiscal Year: 2013
    SUMMARY Ovulation is a complex, inflammation-like process whereby a fully-developed follicle ruptures in response to the actions of the mid-cycle gonadotropin surge, releasing the cumulus-oocyte complex (COC) for passage into the ..
  43. Role of STARD6 in ovarian steroidogenesis
    HOLLY ANNE LAVOIE; Fiscal Year: 2013
    ..In addition to preparation of the ovum for ovulation, another critical function of the ovary is de novo steroid synthesis from cholesterol De novo steroidogenesis ..
  44. Chromium VI-induced toxicity on Female Reproductive Function
    SAKHILA BANU; Fiscal Year: 2012
    ..is that lactation exposure to CrVI induces apoptosis of granulosa cells and follicular atresia, decreases ovulation, compromises pregnancy, and induces preterm labor in the F1 female offspring;and vitamin C mitigates CrVI-..
  45. Upstream Regulation of Kiss1 Cells
    Horacio O de la Iglesia; Fiscal Year: 2010
    b>Ovulation depends on a surge in the release of luteinizing hormone (LH), which in turn depends on a surge of gonadotropin-releasing hormone (GnRH)...
  46. Kisspeptin/Kiss1r in the Female Neuroendocrine Axis
    Robert A Steiner; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ovulation is triggered by neural circuits in the brain, which senses a rising tide of estradiol (E2) and-at the right time-generate a surge of gonadotropin-releasing hormone (GnRH) and luteinizing ..
  47. Molecular Basis of BMP-15 Function
    Shunichi Shimasaki; Fiscal Year: 2012
    ..is a critical growth factor that controls ovarian follicle growth and development, leading to the normal ovulation, thus, female fertility...
  48. Effects of weight and insulin sensitivity on reproductive function in PCOS
    LEANNE MAREE REDMAN; Fiscal Year: 2013
    ..d) no intervention (control group) on neuroendocrine function (pulsatile LH secretion), reproductive function (ovulation rate), ovarian morphology/function and insulin sensitivity...
  49. COOPERATIVE RESEARCH ON INFERTILITY IN PRIMATES
    Richard L Stouffer; Fiscal Year: 2010
    ..using proteomic analyses of follicular fluid to identify novel proteins involved in follicular development and ovulation, as well as markers or mechanisms in polycystic ovarian syndrome (PCOS)...
  50. Mechanisms of Prevention of Ovarian Cancer by Oral Contraceptives
    Malcolm C Pike; Fiscal Year: 2013
    ..One hypothesis is that protection is achieved by blocking ovulation, but growing evidence suggests that it may be related to promoting a favorable progestagenic environment...
  51. p63-Dependent Checkpoints in Oocytes
    Frank D McKeon; Fiscal Year: 2010
    ..is marked by an exceedingly prolonged arrest in meiosis I between homologous chromosome recombination and ovulation, which in humans can last five decades...
  52. Mechanisms of Reduced Fecundity in Endometriosis: A role for MMPs and TIMPs
    KATHY L TIMMS; Fiscal Year: 2012
    ..known that TIMP-1 highly regulates matrix metalloproteinase enzymes (MMPs) critical for follicular development, ovulation and embryo development, we propose endometriotic TIMP-1 is blocking ovarian MMPs required for follicular ..
  53. Use of Gene Therapy: A Tool to Study Reproductive Function
    Ursula B Kaiser; Fiscal Year: 2010
    ..the extent of reproductive recovery achieved by GnRH gene therapy, including ovarian folliculogenesis and ovulation, spermatogenesis, sexual reproductive behavior and fertility...
  54. Contraception by Blockade of Periovulatory Events in Primates
    Richard L Stouffer; Fiscal Year: 2013
    ..whether specific antagonists of select granulosa- or oocyte derived proteins disrupt cumulus-oocyte expansion or ovulation, and hence egg release and fertility during the menstrual cycle...
  55. ACTIONS OF SEMINAL PROTEINS IN MATED DROSOPHILA FEMALES
    MARIANA FEDERICA WOLFNER; Fiscal Year: 2013
    ..Specifically, we will dissect the role of the Acp ovulin in triggering ovulation by determining its site of action, the role of its processing, the identity of its receptor, and whether ovulin ..
  56. Cooperative Contraceptive Research Center: New Contraceptives with Dual Benefits
    REGINE SITRUK WARE; Fiscal Year: 2013
    ..Ill) The evaluation of new endothelin receptor antagonists on ovulation with the goal of developing new specific and highly effective emergency contraceptives will be conducted in ..
  57. MRI STUDIES OF ANGIOGENESIS IN OVARIAN CANCER
    Michal Neeman; Fiscal Year: 2013
    ..Ovarian cancer was linked to ovulation, but the other hand, ovarian cancer is rare in young women, and is significantly more prevalent in ..
  58. Ovulation, inclusion cysts, and p53 mutations in a mouse model of ovarian cancer
    Joanna E Burdette; Fiscal Year: 2010
    ..The etiology of ovarian cancer is unknown, but intervention that blocks ovulation reduces the risk for developing ovarian cancer...
  59. Premature Uterine Ageing and Preterm Delivery
    Jeeyeon Cha; Fiscal Year: 2013
    ..using uterine-specific deletion of the Trp53 gene encoding p53 has been developed, and these mice have normal ovulation, fertilization, and implantation...
  60. Collaborative Genetic Study of Ovarian Cancer Risk
    Marc T Goodman; Fiscal Year: 2012
    ..between the extracellular matrix and ovarian epithelial cells during the wounding and repair associated with ovulation. The ovarian surface epithelium is subject to repeated wounding and healing during ovulation...
  61. Genetic and Environmental Determinants of Germ Cell Development and Follicle Numb
    SONYA MARIE SCHUH-HUERTA; Fiscal Year: 2012
    ..woman's lifetime her oocytes/follicles are continually lost through the process of atresia (cell death) and ovulation. There is great variability in the quality and quantity of the oocyte pool, or ovarian reserve, among women...
  62. A RCT of preconception weight loss vs. OCP in overweight infertile PCOS women
    Richard S Legro; Fiscal Year: 2013
    ..All women will then undergo four cycles of ovulation induction with an oral agent with timed intercourse...
  63. Rosiglitazone and Clomiphene for Ovulation Induction
    Nicholas Cataldo; Fiscal Year: 2002
    ..will evaluate the effectiveness of a new drug combination, rosiglitazone and clomiphene, for the induction of ovulation in anovulatory women with polycystic ovary syndrome (PCOS)...
  64. OVULATION--STUDIES USING IN VITRO PERFUSED OVARIES
    Edward Wallach; Fiscal Year: 1992
    Three aspects of the periovulatory interval will be studied in the rabbit: 1) follicle wall disruption (ovulation); 2) oocyte maturation (nuclear and cytoplasmic); and 3) corpus luteum formation...
  65. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2010
    ..The program of ovulation is activated by a surge of luteinizing hormone, which initiates dramatic changes in molecular, biochemical, and ..
  66. A THECAL ROLE IN OVULATION
    KATHERINE ROBY; Fiscal Year: 1999
    b>Ovulation has been described as a pathophysiological event in which the controlled dissolution and rupture followed by repair of otherwise healthy tissue occurs...
  67. REGULATION OF THE CORPUS LUTEUM
    Anthony Zeleznik; Fiscal Year: 2003
    ..Results of our previous work have identified two dramatic alterations that occur in luteal cells following ovulation: i) a cessation of the expression of the cAMP and PKA- dependent nuclear transcription factor CREB and ii) a ..
  68. Inflammatory Markers in Circulation and Ovarian Cancer Risk
    Alan Arslan; Fiscal Year: 2009
    ..implicated in ovarian cancer development such as pelvic inflammatory disease, endometriosis, and incessant ovulation, an inflammation-like process, support the hypothesis that inflammation is important in ovarian cancer etiology...
  69. APOPTOSIS AND REPRODUCTIVE AGING OF THE FEMALE
    Jonathan Tilly; Fiscal Year: 2003
    ..in the ovaries at birth from which follicles are selected for growth and differentiation to release an egg at ovulation. Each menstrual cycle in adult life is accompanied by the growth of more follicles than are needed for ovulation,..
  70. PROSTAGLANDIN RECEPTOR REGULATION IN THE CORPUS LUTEUM
    Milo Wiltbank; Fiscal Year: 2000
    Prostaglandins (PG) have an essential role in regulating ovarian function including key aspects of ovulation, luteinization, and luteal regression...