menstruation

Summary

Summary: The periodic shedding of the ENDOMETRIUM and associated menstrual bleeding in the MENSTRUAL CYCLE of humans and primates. Menstruation is due to the decline in circulating PROGESTERONE, and occurs at the late LUTEAL PHASE when LUTEOLYSIS of the CORPUS LUTEUM takes place.

Top Publications

  1. pmc VEGF blockade inhibits angiogenesis and reepithelialization of endometrium
    Xiujun Fan
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    FASEB J 22:3571-80. 2008
  2. ncbi Elafin in human endometrium: an antiprotease and antimicrobial molecule expressed during menstruation
    Anne E King
    Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh, Centre for Reproductive Biology, Edinburgh, United Kingdom EH16 4SB
    J Clin Endocrinol Metab 88:4426-31. 2003
  3. ncbi Novel cardiac precursor-like cells from human menstrual blood-derived mesenchymal cells
    Naoko Hida
    Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Stem Cells 26:1695-704. 2008
  4. pmc Menstrual blood-derived cells confer human dystrophin expression in the murine model of Duchenne muscular dystrophy via cell fusion and myogenic transdifferentiation
    Chang Hao Cui
    Department of Reproductive Biology and Pathology, National Institute for Child Health and Development, Tokyo, 157 8535, Japan
    Mol Biol Cell 18:1586-94. 2007
  5. pmc Menstrual blood cells display stem cell-like phenotypic markers and exert neuroprotection following transplantation in experimental stroke
    Cesar V Borlongan
    Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Stem Cells Dev 19:439-52. 2010
  6. ncbi Oestrogen and progesterone regulation of inflammatory processes in the human endometrium
    Anne E King
    University of Edinburgh, Centre for Reproductive Biology, The Queen s Medical Research Institute, United Kingdom
    J Steroid Biochem Mol Biol 120:116-26. 2010
  7. ncbi Menstruation and menstrual hygiene amongst adolescent school girls in Kano, Northwestern Nigeria
    U M Lawan
    Department of Community Medicine, Bayero University Kano and Aminu Kano Te aching Hospital, Kano State
    Afr J Reprod Health 14:201-7. 2010
  8. ncbi Recall of early menstrual history and menarcheal body size: after 30 years, how well do women remember?
    A Must
    Department of Family Medicine and Community Health, School of Medicine, Tufts University, Boston, MA 02111, USA
    Am J Epidemiol 155:672-9. 2002
  9. pmc The evolution of menstruation: a new model for genetic assimilation: explaining molecular origins of maternal responses to fetal invasiveness
    Deena Emera
    Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Bioessays 34:26-35. 2012
  10. ncbi Further evaluation of rizatriptan in menstrual migraine: retrospective analysis of long-term data
    Stephen D Silberstein
    Jefferson Headache Center, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA
    Headache 42:917-23. 2002

Detail Information

Publications328 found, 100 shown here

  1. pmc VEGF blockade inhibits angiogenesis and reepithelialization of endometrium
    Xiujun Fan
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    FASEB J 22:3571-80. 2008
    ..In summary, we provide novel experimental data indicating that VEGF is essential for endometrial neoangiogenesis during postmenstrual/postpartum repair...
  2. ncbi Elafin in human endometrium: an antiprotease and antimicrobial molecule expressed during menstruation
    Anne E King
    Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh, Centre for Reproductive Biology, Edinburgh, United Kingdom EH16 4SB
    J Clin Endocrinol Metab 88:4426-31. 2003
    ..Real-time quantitative PCR showed that expression of elafin mRNA peaked during menstruation. Elafin protein was localized to leukocytes scattered in the endometrial stroma during the late secretory and ..
  3. ncbi Novel cardiac precursor-like cells from human menstrual blood-derived mesenchymal cells
    Naoko Hida
    Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Stem Cells 26:1695-704. 2008
    ..Thus, MMCs appear to be a potential novel, easily accessible source of material for cardiac stem cell-based therapy...
  4. pmc Menstrual blood-derived cells confer human dystrophin expression in the murine model of Duchenne muscular dystrophy via cell fusion and myogenic transdifferentiation
    Chang Hao Cui
    Department of Reproductive Biology and Pathology, National Institute for Child Health and Development, Tokyo, 157 8535, Japan
    Mol Biol Cell 18:1586-94. 2007
    ..These results demonstrate that the endometrial progenitor cells and menstrual blood-derived cells can transfer dystrophin into dystrophied myocytes through cell fusion and transdifferentiation in vitro and in vivo...
  5. pmc Menstrual blood cells display stem cell-like phenotypic markers and exert neuroprotection following transplantation in experimental stroke
    Cesar V Borlongan
    Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Stem Cells Dev 19:439-52. 2010
    ..The present neurostructural and behavioral benefits afforded by transplanted menstrual blood-derived cells support their use as a stem cell source for cell therapy in stroke...
  6. ncbi Oestrogen and progesterone regulation of inflammatory processes in the human endometrium
    Anne E King
    University of Edinburgh, Centre for Reproductive Biology, The Queen s Medical Research Institute, United Kingdom
    J Steroid Biochem Mol Biol 120:116-26. 2010
    ..that the endometrium is optimally prepared for potential embryo implantation but in the absence of an embryo, menstruation occurs to allow endometrial regeneration...
  7. ncbi Menstruation and menstrual hygiene amongst adolescent school girls in Kano, Northwestern Nigeria
    U M Lawan
    Department of Community Medicine, Bayero University Kano and Aminu Kano Te aching Hospital, Kano State
    Afr J Reprod Health 14:201-7. 2010
    This study examined the knowledge and practices of adolescent school girls in Kano, Nigeria around menstruation and menstrual hygiene. Data was collected quantitatively and analyzed using Epi info version 3.2.05...
  8. ncbi Recall of early menstrual history and menarcheal body size: after 30 years, how well do women remember?
    A Must
    Department of Family Medicine and Community Health, School of Medicine, Tufts University, Boston, MA 02111, USA
    Am J Epidemiol 155:672-9. 2002
    ..The failure to identify certain menstrual characteristics as exposures for subsequent disease may reflect limitations in the accuracy and precision of the recalled measures...
  9. pmc The evolution of menstruation: a new model for genetic assimilation: explaining molecular origins of maternal responses to fetal invasiveness
    Deena Emera
    Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Bioessays 34:26-35. 2012
    ..while most mammals do not? Here, we present our answer to this long-debated question, arguing that (i) menstruation occurs as a mechanistic consequence of hormone-induced differentiation of the endometrium (referred to as ..
  10. ncbi Further evaluation of rizatriptan in menstrual migraine: retrospective analysis of long-term data
    Stephen D Silberstein
    Jefferson Headache Center, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA
    Headache 42:917-23. 2002
    ..To determine the long-term efficacy of oral rizatriptan 10-mg wafers in the treatment of menstrual migraine attacks...
  11. pmc The immunocytochemical distribution of leukocytic subpopulations in human endometrium
    B R Kamat
    Am J Pathol 127:66-73. 1987
    ..Thus, the normal endometrium has an important population of immunologically competent cells. Further study of these cell populations may elucidate their contribution, if any, to pathologic conditions in the endometrium...
  12. pmc Longitudinal study of the dynamics of vaginal microflora during two consecutive menstrual cycles
    Guido Lopes Dos Santos Santiago
    Laboratory for Bacteriology Research, Department of Clinical Chemistry, Microbiology, and Immunology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
    PLoS ONE 6:e28180. 2011
    ..of the menstrual cycle on the different categories of vaginal microflora and assessed possible causes, such as menstruation and sexual intercourse, of VMF disturbance...
  13. ncbi Short-term frovatriptan for the prevention of difficult-to-treat menstrual migraine attacks
    J L Brandes
    Nashville Neuroscience Group, PC, Vanderbilt University School of Medicine, Nashville, TN, USA 37203
    Cephalalgia 29:1133-48. 2009
    ..d. (P < 0.001) and b.i.d. (P < 0.001) vs. placebo. Both frovatriptan regimens were well tolerated. In women with difficult-to-treat MM, a 6-day regimen of frovatriptan significantly reduced MM incidence and severity...
  14. ncbi Migraine without aura and reproductive life events: a clinical epidemiological study in 1300 women
    F Granella
    University Center for Adaptive Disorders and Headache (UCADH, Unit of Parma (Department of Neurology, University of Parma, Italy
    Headache 33:385-9. 1993
    ..This form of migraine shows more frequently a menstrual periodicity, and usually improves during pregnancy. Furthermore, menstrual migraine patients show social and cultural characteristics with distinguish them from other women...
  15. ncbi Transforming growth factor-beta1 attenuates expression of both the progesterone receptor and Dickkopf in differentiated human endometrial stromal cells
    Nicole Kane
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Mol Endocrinol 22:716-28. 2008
    ..TGFbeta1 is thought to be intimately involved in cyclic tissue remodeling and inflammatory events associated with menstruation. Menstruation is initiated by progesterone withdrawal; however, the underlying mechanisms are not well ..
  16. ncbi Identification of chemokines important for leukocyte recruitment to the human endometrium at the times of embryo implantation and menstruation
    Rebecca L Jones
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3186, Australia
    J Clin Endocrinol Metab 89:6155-67. 2004
    ..study to use an unbiased approach to screen for endometrial chemokines, and we report the selective regulation of chemokines, corresponding to the recruitment of distinct leukocyte subpopulations required for pregnancy and menstruation.
  17. ncbi Expression and regulation of vascular endothelial growth factor ligands and receptors during menstruation and post-menstrual repair of human endometrium
    C Punyadeera
    Research Institute for Growth and Development GROW Department of Pathology, University Hospital Maastricht and University Maastricht, Maastricht, The Netherlands
    Mol Hum Reprod 12:367-75. 2006
    Regeneration and growth of the human endometrium after shedding of the functional layer during menstruation depends on an adequate angiogenic response...
  18. ncbi Menstrual hygiene among adolescent schoolgirls in Mansoura, Egypt
    Abdel Hady El-Gilany
    Community Medicine Department, Faculty of Medicine, University of Mansoura, Mansoura, Egypt
    Reprod Health Matters 13:147-52. 2005
    ..type of sanitary protection used, frequency of changing pads or cloths, means of disposal and bathing during menstruation. Girls were selected by cluster sampling technique in public secondary schools in urban and rural areas...
  19. ncbi Incidence, time course, and determinants of menstrual bleeding after breast cancer treatment: a prospective study
    Jeanne A Petrek
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 24:1045-51. 2006
    ..To assess ovarian function using the surrogate of monthly bleeding after breast cancer treatment in premenopausal women...
  20. ncbi Menstrual knowledge and practices of female adolescents in urban Karachi, Pakistan
    Tazeen Saeed Ali
    The Aga Khan University, School of Nursing and Department of Community Health Sciences, Karachi 74800, Sindh, Pakistan
    J Adolesc 33:531-41. 2010
    b>Menstruation is a normal physiological process that is managed differently according to various social and cultural understandings...
  21. ncbi Daily low-dose mifepristone has contraceptive potential by suppressing ovulation and menstruation: a double-blind randomized control trial of 2 and 5 mg per day for 120 days
    Audrey Brown
    Contraceptive Development Network, Centre for Reproductive Biology, University of Edinburgh, Edinburgh, EH3 9ET, United Kingdom
    J Clin Endocrinol Metab 87:63-70. 2002
    ..We conclude that mifepristone in low daily doses inhibits ovulation and induces amenorrhea in the majority of women and has the potential to be developed as a novel estrogen- free oral contraceptive pill...
  22. ncbi A comparison of modality-specific somatosensory changes during menstruation in dysmenorrheic and nondysmenorrheic women
    Priti Bajaj
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Denmark
    Clin J Pain 18:180-90. 2002
    ..regimen applied both within and outside areas of referred menstrual pain in dysmenorrheic women, over four phases of confirmed ovulatory cycles, and to compare them with thresholds in nondysmenorrheic women during menstruation.
  23. ncbi Menorrhagia I: measured blood loss, clinical features, and outcome in women with heavy periods: a survey with follow-up data
    Pamela E Warner
    Division of Community Health Sciences, University of Edinburgh Medical School, Obstetrics and Gynaecology, University of Edinburgh, Centre for Reproductive Biology, Edinburgh, Scotland, United Kingdom
    Am J Obstet Gynecol 190:1216-23. 2004
    ..Menorrhagia is defined as blood loss of >80 mL, but in routine clinical practice measurement is seldom undertaken. Our aim was to identify the features of the clinical history that best predict menorrhagic blood loss...
  24. ncbi Structural changes in endometrial basal glands during menstruation
    R Garry
    Department of Gynaecology, University of Western Australia, Perth, Australia
    BJOG 117:1175-85. 2010
    ..To prospectively observe the changes occurring in endometrial glandular morphology during menstrual shedding and regeneration...
  25. ncbi Matrix metalloproteinases and endometriosis
    Kevin G Osteen
    Women s Reproductive Health Research Center, Department of Obstetrics Gynecology, Vanderbilt University School of Medicine, B 1100 Medical Center North, Nashville, TN 37232, USA
    Semin Reprod Med 21:155-64. 2003
    Retrograde menstruation represents a plausible explanation for the development of most cases of endometriosis; nevertheless, additional factors must contribute to the development of disease in only 10 to 20% of women...
  26. ncbi Evaluation of menstrual bleeding patterns: a new proposal for a universal guideline based on the analysis of more than 4500 bleeding diaries
    C Gerlinger
    Clinical Statistics Europe, Bayer Schering Pharma AG, Berlin, Germany
    Eur J Contracept Reprod Health Care 12:203-11. 2007
    ..To develop a universal guideline allowing the comparison of interventions like oral contraceptives and hormone replacement therapy with an impact on menstrual bleeding pattern...
  27. ncbi Progesterone withdrawal up-regulates fibronectin and integrins during menstruation and repair in the rhesus macaque endometrium
    W Cao
    Northwestern University, Chicago, IL 60611, USA
    Hum Reprod 22:3223-31. 2007
    ..To determine whether these molecules play similar roles during menstrual repair, we evaluated the expression and localization of FN and specific Itgs in the primate endometrium under hormonally controlled conditions...
  28. ncbi Menstrual health care behavior and associated factors among female elementary students in the Hualien region
    Yu Ting Chang
    Department of Nursing, Tzu Chi College of Technology
    J Nurs Res 16:8-16. 2008
    ..The results of this study show that the majority of the respondents felt that menstruation had an influence on their emotions (74.8%), daily life (73.1%), schoolwork (61.6%), and social interaction (50...
  29. ncbi The endocrine and paracrine control of menstruation
    Patrick Henriet
    Cell Biology Unit, de Duve Institute, Universite Catholique de Louvain, Avenue Hippocrate, 75, B 1200 Bruxelles, Belgium
    Mol Cell Endocrinol 358:197-207. 2012
    During the reproductive life, the human endometrium undergoes cycles of substantial remodeling including, at menstruation, a massive but delimited tissue breakdown immediately followed by scarless repair...
  30. ncbi Mimicking the events of menstruation in the murine uterus
    M Brasted
    Uterine Biology Laboratory, Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    Biol Reprod 69:1273-80. 2003
    b>Menstruation and endometrial regeneration occur during every normal reproductive cycle in women and some Old World primates...
  31. ncbi Differential expression and regulation of nuclear oligomerization domain proteins NOD1 and NOD2 in human endometrium: a potential role in innate immune protection and menstruation
    Anne E King
    Reproductive and Developmental Sciences, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, UK
    Mol Hum Reprod 15:311-9. 2009
    ..NOD2 is up-regulated in the late secretory phase of the menstrual cycle suggesting a role in menstruation. Both proteins are immunolocalized in endometrial epithelium, stroma and endothelium...
  32. ncbi Withdrawal of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation
    Norihiro Sugino
    Division of Obstetrics and Gynecology, Department of Reproductive, Pediatric and Infectious Science, Yamaguchi University School of Medicine, Ube, Japan
    J Reprod Dev 50:215-25. 2004
    ..In conclusion, EP-withdrawal stimulates COX-2 expression and PGF2alpha production through ROS-induced NF-kappaB activation, suggesting a possible mechanism for menstruation.
  33. pmc Intravaginal and menstrual practices among women working in food and recreational facilities in Mwanza, Tanzania: implications for microbicide trials
    Caroline F Allen
    Medical Research Council Social and Public Health Sciences Unit, University of Glasgow, Glasgow G12 8RZ, UK
    AIDS Behav 14:1169-81. 2010
    ..Intravaginal and menstrual practices and associated behaviours and demographic factors should be measured and monitored throughout microbicide trials to enable analyses of their impacts on microbicide effectiveness...
  34. ncbi Socio-cultural aspects of menstruation in an urban slum in Delhi, India
    S Garg
    Department of Community Medicine, Maulana Azad Medical College, New Delhi 110 002, India
    Reprod Health Matters 9:16-25. 2001
    This paper attempts to understand the experience of menstruation in the socio-cultural context of an urban Indian slum...
  35. ncbi Menstruation: induction by matrix metalloproteinases and inflammatory cells
    L A Salamonsen
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    J Reprod Immunol 44:1-27. 1999
    b>Menstruation occurs at the end of a normal reproductive cycle in the human female, following the fall in progesterone resulting from the demise of the corpus luteum...
  36. ncbi Matrix metalloproteinases in endometrial breakdown and repair: functional significance in a mouse model
    Tu uhevaha J Kaitu'u
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Biol Reprod 73:672-80. 2005
    Considerable correlative evidence suggests an important role for matrix metalloproteinases (MMPs) in menstruation, a process which occurs naturally in very few species...
  37. ncbi Where the education system and women's bodies collide: The social and health impact of girls' experiences of menstruation and schooling in Tanzania
    Marni Sommer
    Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Adolesc 33:521-9. 2010
    ..Girls have pragmatic and realistic recommendations for how to improve school environments, ideas that should be incorporated as effective methods for improving girls' academic experiences and their healthy transitions to womanhood...
  38. ncbi Determination of total menstrual blood loss
    K M Wyatt
    Academic Department of Obstetrics and Gynaecology, North Staffordshire Hospital, Stoke-on-Trent, United Kingdom
    Fertil Steril 76:125-31. 2001
    ..It is no longer appropriate to ignore extraneous blood loss, particularly as there is no correlation between extraneous blood loss and that measured on feminine hygiene products...
  39. ncbi Determinants of recovery from amenorrhea in premenopausal breast cancer patients receiving adjuvant chemotherapy in the taxane era
    Alessandro Marco Minisini
    Department of Medical Oncology, University Hospital of Udine, Udine, Italy
    Anticancer Drugs 20:503-7. 2009
    ..04) were associated with an increased probability of permanent chemotherapy-induced amenorrhea. Recovery of menses after chemotherapy-induced amenorrhea occurs more probably in younger women, with no pregnancies and receiving taxanes...
  40. pmc True and sham acupuncture produced similar frequency of ovulation and improved LH to FSH ratios in women with polycystic ovary syndrome
    Lisa M Pastore
    Department of Obstetrics Gynecology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 96:3143-50. 2011
    ..Acupuncture may represent a nonpharmaceutical treatment for women with polycystic ovary syndrome (PCOS), based on four studies...
  41. ncbi Prospective analysis of factors related to migraine attacks: the PAMINA study
    C Wöber
    Department of Neurology, Medical University of Vienna, Vienna, Austria
    Cephalalgia 27:304-14. 2007
    ..b>Menstruation had the most prominent effect, increasing the hazard of occurrence or persistence of headache and migraine by ..
  42. ncbi Endometrial mesenchymal stem cells isolated from the menstrual blood
    R A Musina
    V I Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Russia
    Bull Exp Biol Med 145:539-43. 2008
    ..Specific features of this cell type are high clonogenic activity and low capacity to adipocyte differentiation...
  43. ncbi The next generation of burns treatment: intelligent films and matrix, controlled enzymatic debridement, and adult stem cells
    H Drago
    Banco de Tejidos, Hospital de Quemados, CABA, Argentina
    Transplant Proc 42:345-9. 2010
    ....
  44. ncbi Naratriptan as short-term prophylaxis of menstrually associated migraine: a randomized, double-blind, placebo-controlled study
    L Newman
    St. Luke's-Roosevelt Hospital Center, Headache Institute, New York, NY 10019, USA
    Headache 41:248-56. 2001
    ..5 mg, was not statistically superior to placebo for any measure. CONCLUSIONS: Naratriptan, 1 mg, with tolerability similar to placebo, is an effective, short-term, prophylactic treatment for menstrually associated migraine...
  45. ncbi Characterization of consistent triggers of migraine with aura
    Anne Werner Hauge
    Department of Neurology, University of Copenhagen and Glostrup Hospital, Denmark
    Cephalalgia 31:416-38. 2011
    ..The aim of the present study was to characterize perceived consistent triggers of migraine with aura (MA)...
  46. ncbi Effective treatment of heavy and/or prolonged menstrual bleeding with an oral contraceptive containing estradiol valerate and dienogest: a randomized, double-blind Phase III trial
    I S Fraser
    Department of Obstetrics and Gynaecology, Central Clinical School, D02 QEII Research Institute for Mothers and Infants, University of Sydney, Sydney, NSW 2006, Australia
    Hum Reprod 26:2698-708. 2011
    ..This double-blind trial investigated the efficacy and safety of estradiol valerate/dienogest (E(2)V/DNG) for the treatment of heavy menstrual bleeding without recognizable organic pathology...
  47. ncbi Menstrual-like changes in mice are provoked through the pharmacologic withdrawal of progesterone using mifepristone following induction of decidualization
    X B Xu
    Department of Cell Biology, National Research Institute for Family Planning, Beijing 100081, People s Republic of China
    Hum Reprod 22:3184-91. 2007
    Cyclic shedding of the endometrium is unique to menstruating species, and mouse menstruation models by physiologic progesterone withdrawal have been previously reported...
  48. ncbi What is the desired menstrual frequency of women without menstruation-related symptoms?
    Simone Ferrero
    Department of Obstetrics and Gynecology, San Martino Hospital and University of Genoa, 16132 Genoa, Italy
    Contraception 73:537-41. 2006
    This study aimed to investigate the desired menstrual frequency of subjects without menstruation-related symptoms.
  49. pmc Bacterial vaginosis in relation to menstrual cycle, menstrual protection method, and sexual intercourse in rural Gambian women
    L Morison
    MRC Tropical Epidemiology Group, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Sex Transm Infect 81:242-7. 2005
    ..To examine the occurrence of bacterial vaginosis (BV) over the menstrual cycle and in relation to menstrual protection materials and sexual intercourse in a rural African setting...
  50. pmc Comprehensive analysis of leukocytes, vascularization and matrix metalloproteinases in human menstrual xenograft model
    Yong Guo
    Graduate School, Peking Union Medical College, Beijing, People s Republic of China
    PLoS ONE 6:e16840. 2011
    ..However, mouse is not a natural menstruation animal, and the menstruation model using external stimuli may not truly reflect the occurrence and development ..
  51. ncbi Attitudes and feelings towards menstruation and womanhood in girls at menarche
    Gun I Rembeck
    Youth Centre in Lerum, Primary Healthcare, Southern Alvsborg County, Sweden
    Acta Paediatr 95:707-14. 2006
    To elucidate early adolescent girls' attitudes, thoughts and feelings towards menstruation and their bodies.
  52. ncbi Validation of a rapid alkaline hematin technique to measure menstrual blood loss on feminine towels containing superabsorbent polymers
    Julia L Magnay
    Keele Menstrual Disorders Laboratory, Institute for Science and Technology in Medicine, Guy Hilton Research Centre, Thornburrow Drive, Hartshill, Stoke on Trent, United Kingdom
    Fertil Steril 96:394-8. 2011
    ..To validate the semiautomated alkaline hematin technique for rapid measurement of menstrual blood loss on ultrathin sanitary towels with a superabsorbent polymer component...
  53. ncbi Assessment of menstruation in the vervet (Cercopithecus aethiops)
    Rebecca L Carroll
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Am J Primatol 69:901-16. 2007
    Vervet monkeys (Chlorocebus aethiops) are Old World nonhumans that display attenuated menstruation that requires detection by vaginal swab. The physiology underlying attenuated menstruation in this species has not been previously studied...
  54. ncbi Young girls with malignant ovarian germ cell tumors can undergo normal menarche and menstruation after fertility-preserving surgery and adjuvant chemotherapy
    Seung Chul Yoo
    Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, South Korea
    Acta Obstet Gynecol Scand 89:126-30. 2010
    ..9%) subsequently had normal menarche. Among the 16 adolescent patients, 15 (93.8%) resumed normal menstruation and 1 had premature ovarian failure. Conclusion...
  55. ncbi Cultural practices relating to menarche and menstruation among adolescent girls in Taiwan--qualitative investigation
    H L Liu
    Nursing Department, College of Nursing, Central Taiwan University of Science and Technology, Taichung City, Taiwan
    J Pediatr Adolesc Gynecol 25:43-7. 2012
    The aim of this study was to qualitatively record the cultural attitudes and practices associated with menarche and menstruation in Taiwanese girls, particularly with respect to coping mechanisms.
  56. ncbi Endocrine regulation of menstruation
    Henry N Jabbour
    Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocr Rev 27:17-46. 2006
    ..In the absence of pregnancy, the human endometrium is sloughed off at menstruation over a period of a few days...
  57. ncbi Production of endometrial matrix metalloproteinases, but not their tissue inhibitors, is modulated by progesterone withdrawal in an in vitro model for menstruation
    L A Salamonsen
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    J Clin Endocrinol Metab 82:1409-15. 1997
    Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are implicated in normal menstruation, but the mechanism of their regulation is not yet clear...
  58. ncbi Migraine in women
    Christine L Lay
    Department of Medicine, Division of Neurology, Centre For Headache, Women s College Hospital, 76 Grenville Street, Toronto, Ontario, Canada
    Neurol Clin 27:503-11. 2009
    ..Hence practitioners treating women with migraine need to have a clear understanding of these special considerations...
  59. ncbi Almotriptan for menstrually related migraine
    Gennaro Bussone
    Besta Neurological Institute, Via Celoria 11, Milan, Italy
    Expert Opin Pharmacother 12:1933-43. 2011
    ..Since MRM may be difficult to treat, it is important to find an appropriate treatment option for women suffering from this condition...
  60. ncbi Breast-feeding pattern and onset of menstruation among Yoruba mothers of South-west Nigeria
    Oluwafemi Kuti
    Department of Obstetrics, Gynaecology and Perinatology, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Nigeria
    Eur J Contracept Reprod Health Care 12:335-9. 2007
    ..To determine the breast-feeding practices and duration of lactational amenorrhoea among women within the first year of delivery in a Nigerian population...
  61. ncbi Menstrual experiences and beliefs: a multicountry study of relationships with fertility and fertility regulating methods
    L J Severy
    College of Liberal Arts and Sciences, University of Florida, Gainesville 32611
    Women Health 20:1-20. 1993
    ..women generally experience (behavior and beliefs about sexual, personal, social, and dietary factors) during menstruation as baseline data...
  62. ncbi Women's attitudes towards monthly bleeding: results of a global population-based survey
    Anne Szarewski
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, London, UK
    Eur J Contracept Reprod Health Care 17:270-83. 2012
    ..Monthly bleeding can be uncomfortable and inconvenient. Fifty years after the introduction of the pill, one wonders whether women still want to bleed every month...
  63. ncbi Perceptions and practices on menstruation amongst Nigerian secondary school girls
    Echendu Dolly Adinma
    Department of Community Medicine, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria
    Afr J Reprod Health 12:74-83. 2008
    ..550 secondary school girls in southeastern Nigeria to determine their perceptions, problems, and practices on menstruation. Majority of the students, (75.6%), were aged 15-17 years. Only 39...
  64. pmc Sanitary pad interventions for girls' education in Ghana: a pilot study
    Paul Montgomery
    Centre for Evidence Based Intervention, University of Oxford, Oxford, Oxfordshire, United Kingdom
    PLoS ONE 7:e48274. 2012
    ..Following the MRC Framework for Complex Interventions, a pilot controlled study was conducted in Ghana to assess the role of sanitary pads in girls' education...
  65. ncbi Detailed clinical and molecular study of 20 females with Xq deletions with special reference to menstruation and fertility
    Catherine L Mercer
    Wessex Clinical Genetics Service, University Hospital Southampton NHS Foundation Trust, Princess Anne Hospital, Coxford Road, Southampton, UK
    Eur J Med Genet 56:1-6. 2013
    ..Features often associated with Turner syndrome were not common in our study and excluding puberty, menarche and menstruation, the phenotypes observed were present in only a minority of women and were not specific to the X chromosome...
  66. ncbi Cultural perceptions and practices around menarche and adolescent menstruation in the United States
    Margaret L Stubbs
    Department of Psychology, Chatham University, Pittsburgh, Pennsylvania 15232, USA
    Ann N Y Acad Sci 1135:58-66. 2008
    ..Current research suggests that girls are not very knowledgeable about menstruation, and that menstrual education continues to provide girls with mixed messages, such as: menstruation is a normal,..
  67. ncbi Adolescent girls define menstruation: a multiethnic exploratory study
    Kelly Orringer
    Department of Pediatrics, University of Michigan, Howell, Michigan 48843, USA
    Health Care Women Int 31:831-47. 2010
    Incomplete understanding of menstruation may place girls at risk for sexually transmitted diseases (STDs) and unintended pregnancy...
  68. ncbi The impact of cyclophosphamide on menstruation and pregnancy in women with rheumatologic disease
    L E Harward
    Department of Medicine, Medical University of South Carolina, USA
    Lupus 22:81-6. 2013
    ..We compared the reproductive health histories of young women with rheumatologic disease with and without prior CYC exposure to identify the impact of this medication on this important component of health...
  69. ncbi Progestin-regulated expression of tissue factor in decidual cells: implications in endometrial hemostasis, menstruation and angiogenesis
    Frederick Schatz
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, Room 335 FMB, P O Box 208063, New Haven, CT 06520 8063, USA
    Steroids 68:849-60. 2003
    ..transformed decidualization-associated hemostasis of the luteal phase endometrium to the hemorrhagic milieu of menstruation. Transient transfections with TF promoter constructs containing SP and EGR-1 binding sites before and after ..
  70. ncbi Menstruation across time: menarche, menstrual attitudes, experiences, and behaviors
    Marianne E McPherson
    Harvard University, Cambridge, Massachusetts, USA
    Womens Health Issues 14:193-200. 2004
    ..This study invites further investigation of the psychology of menstruation and suggests connecting menstruation with other women's health issues.
  71. ncbi Menstruation and cardiovascular vulnerability
    Martin Terplan
    Arch Intern Med 165:120. 2005
  72. ncbi The effect of community-based health education intervention on management of menstrual hygiene among rural Indian adolescent girls
    A R Dongre
    Dr Sushila Nayar School of Public Health, Mahatma Gandhi Institute of Medical Sciences, Sewagram, 442 102, India
    World Health Popul 9:48-54. 2007
    ..To study the effect of a community-based health education intervention on awareness and behaviour change of rural adolescent girls regarding their management of menstrual hygiene...
  73. ncbi Inflammation, leukocytes and menstruation
    Jemma Evans
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Rev Endocr Metab Disord 13:277-88. 2012
    b>Menstruation has many of the features of an inflammatory process. The complexity and sequence of inflammatory-type events leading to the final tissue breakdown and bleeding are slowly being unravelled...
  74. ncbi Impact of a health education program for secondary school Saudi girls about menstruation at Riyadh city
    Ebtisam M Fetohy
    Health Administration and Behavioral Sciences Dep, High Institute of Public Health, Alexandria University, Egypt
    J Egypt Public Health Assoc 82:105-26. 2007
    ..360, 0.252 respectively). The study recommended the replication of the same program among elementary, preparatory, and other secondary schools for improvement of students' menstrual knowledge, attitudes and practice...
  75. ncbi Role of nitric oxide in implantation and menstruation
    K Chwalisz
    Women s Health Care, Jenapharm GmbH and Co KG, Jena, Germany
    Hum Reprod 15:96-111. 2000
    ..that NO plays an important role in endometrial functions such as endometrial receptivity, implantation and menstruation. In rodents, both iNOS and eNOS are highly up-regulated in the implantation sites, and NOS inhibitors show ..
  76. ncbi Complement factor I deficiency associated with recurrent meningitis coinciding with menstruation
    C González-Rubio
    Immunology Unit, Hospital Universitario, La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain
    Arch Neurol 58:1923-8. 2001
    ..This deficiency causes a permanent uncontrolled activation of the alternative pathway resulting in massive consumption of C3...
  77. ncbi The endocrinology of menstruation--a role for the immune system
    H O Critchley
    Centre for Reproductive Biology, The University of Edinburgh, UK
    Clin Endocrinol (Oxf) 55:701-10. 2001
    ..prepares the endometrium for implantation, but in the absence of pregnancy, progesterone withdrawal leads to menstruation and cyclic repair...
  78. ncbi Decoding implantation and menstruation: the tale of two opposing signals
    Siamak Tabibzadeh
    Dept of Obstetrics and Gynecology and Fetomaternal Medicine, Stony Brook University, Stony Brook, NY 11794, USA
    Front Biosci 7:d1475-86. 2002
    ..sequential phases of proliferation, and secretory changes followed by tissue shedding and bleeding during menstruation. Tissue remodeling is a distinct feature of human endometrium in the secretory phase which prepares endometrium ..
  79. ncbi Menstrual migraine
    E Anne MacGregor
    The City of London Migraine Clinic, London, UK
    Curr Opin Neurol 21:309-15. 2008
    ..Menstrual migraine is prevalent but it is only recently that research has specifically addressed the pathophysiology and management of this disabling condition...
  80. ncbi Inflammatory mediators and endometrial function--focus on the perivascular cell
    Rodney W Kelly
    Human Reproductive Sciences Unit, Medical Research Council, Centre for Reproductive Biology, University of Edinburgh, UK
    J Reprod Immunol 57:81-93. 2002
    Human endometrium has a unique vascular architecture that allows menstruation, the shedding of a well-vascularised tissue layer, with limited bleeding...
  81. ncbi Prophylaxis of menstrual migraine with triptans: problems and possibilities
    Elizabeth Loder
    Harvard Medical School and Pain and Headache Management Programs, Spaulding Rehabilitation Hospital, Boston, MA, USA
    Neurology 59:1677-81. 2002
    b>Menstruation is a prominent, predictable attack trigger for many women with migraine...
  82. ncbi Consequences of a long-term raw food diet on body weight and menstruation: results of a questionnaire survey
    C Koebnick
    Institute of Nutritional Science Justus Liebig University of Giessen, Germany
    Ann Nutr Metab 43:69-79. 1999
    ..To examine the relationship between the strictness of long-term raw food diets and body weight loss, underweight and amenorrhea...
  83. pmc Are menstrual and nonmenstrual migraine attacks different?
    Kjersti Grøtta Vetvik
    Head and Neck Research Group, Research Centre, Akershus University Hospital, 1478, Lørenskog, Oslo, Norway
    Curr Pain Headache Rep 15:339-42. 2011
    ..Collection of both prospective and retrospective data is warranted, and headache diagnosis base on interviews by physicians with interest in headache are more precise than lay interviews or questionnaires...
  84. ncbi Sex hormones and primary headaches other than migraine
    Doris Lieba-Samal
    Department of Neurology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Curr Pain Headache Rep 15:407-14. 2011
    ..headache has been studied less extensively, but there is at least some evidence that hormones in general, and menstruation, pregnancy, or menopause in particular, also impact these disorders...
  85. ncbi Metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 ectodomain decreases endocytic clearance of endometrial matrix metalloproteinase-2 and -9 at menstruation
    Charlotte Selvais
    Cell Biology Unit, de Duve Institute, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Endocrinology 150:3792-9. 2009
    ....
  86. ncbi [Volt-ampere characteristics of Yuan points of three yin channels of hand in women before, during and after menstruation]
    Jian zi Wei
    College of Acupuncture, Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    Zhong Xi Yi Jie He Xue Bao 4:260-4. 2006
    ..To observe the changes of volt-ampere characteristics of Yuan-Primary acupoints in women before, during and after menstruation, and to find out the relationships between Qi-blood in human body and volt-ampere characteristics of acupoints, ..
  87. ncbi Impact of breast cancer chemotherapy on ovarian reserve: a prospective observational analysis by menstrual history and ovarian reserve markers
    Andrea Reh
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York Presbyterian Weill Cornell Medical Center, New York, New York 10021, USA
    Fertil Steril 90:1635-9. 2008
    ..To determine whether addition of taxanes to anthracycline and cyclophosphamide regimens impact ovarian function as assessed by menstrual history and ovarian reserve markers...
  88. ncbi Current topics and controversies in menstrual migraine
    Anne H Calhoun
    University of North Carolina, Anesthesiology and Psychiatry and Carolina Headache Institute, Chapel Hill, NC 27516, USA
    Headache 52:8-11. 2012
    ..This article takes a closer look at some of these products, including concerns surrounding them, non-contraceptive benefits, and their potential role as preventive agents for MRM...
  89. ncbi Reversible suppression of menstruation with progesterone antagonists in rhesus macaques
    O D Slayden
    Division of Reproductive Sciences, Oregon Regional Primate Research Center, Beaverton OR 97006, USA
    Hum Reprod 16:1562-74. 2001
    ..RESULTS: The results in naturally cycling animals showed that ZK 137 316 blocked menstruation in all animals, but doses of 0.05 mg/kg blocked ovulation in 55.5% of animals and doses of 0...
  90. ncbi Quantitative measurements of menstrual blood loss in ovulatory and anovulatory cycles in middle- and late-reproductive age and the menopausal transition
    Georgina E Hale
    Department of Obstetrics and Gynaecology, Queen Elizabeth II Research Institute for Mothers and Infants, University of Sydney, New South Wales, Australia
    Obstet Gynecol 115:249-56. 2010
    ..To measure menstrual blood loss before and during the menopausal transition and to explore the relationships between menstrual blood loss and menstrual cycle irregularity and reproductive hormone levels...
  91. ncbi Estimating menstrual blood loss in women with normal and excessive menstrual fluid volume
    I S Fraser
    Sydney Centre for Reproductive Health Research, Family Planning NSW, Sydney, Australia
    Obstet Gynecol 98:806-14. 2001
    To examine the relationship between total fluid volume at menstruation and the volume of blood loss, and to assess the feasibility of using total fluid volume to estimate menstrual blood loss.
  92. ncbi The FIGO recommendations on terminologies and definitions for normal and abnormal uterine bleeding
    Ian S Fraser
    Department of Obstetrics and Gynaecology, University of Sydney, Camperdown, Australia
    Semin Reprod Med 29:383-90. 2011
    ..It is anticipated that these terminologies and definitions will be reviewed again on a regular basis through the International Federation of Gynecology and Obstetrics Menstrual Disorders Working Group...
  93. ncbi Endometrial leukocytes and menstruation
    L A Salamonsen
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Hum Reprod Update 6:16-27. 2000
    This review examines evidence supporting the concept that menstruation occurs as a result of an inflammatory process...
  94. ncbi Characteristics of menstruation and pregnancy and the risk of lung cancer in women
    Anita Koushik
    Departement de Medecine sociale et preventive, Universite de Montreal, Montreal, QC, Canada
    Int J Cancer 125:2428-33. 2009
    ..We investigated the association between characteristics of menstruation and pregnancy in relation to lung cancer risk in a population-based case-control study carried out in Montreal, ..
  95. ncbi Coping with menstruation: understanding the needs of women with Parkinson's disease
    Debbie Tolson
    School of Nursing, Midwifery and Community Health, Glasgow Caledonian University, Glasgow, UK
    J Adv Nurs 40:513-21. 2002
    To understand how women with Parkinson's disease (PD) experience and cope with menstruation and associated gynaecological problems, and adjustments to womanhood. This paper focuses on menstruation.
  96. ncbi Role of menstruation in contraceptive choice among HIV-infected women in Soweto, South Africa
    Fatima Laher
    Perinatal HIV Research Unit, Soweto, Johannesburg, Gauteng Province, South Africa
    Contraception 81:547-51. 2010
    ..It is unknown whether HIV-infected women are more sensitive to menstrual changes and how this affects contraceptive choice. This study describes perceptions toward menses and contraceptive-induced amenorrhea among HIV-infected women...
  97. ncbi Progesterone withdrawal up-regulates vascular endothelial growth factor receptor type 2 in the superficial zone stroma of the human and macaque endometrium: potential relevance to menstruation
    N R Nayak
    Oregon Regional Primate Research Center, Beaverton 97006, USA
    J Clin Endocrinol Metab 85:3442-52. 2000
    ..we hypothesize that VEGF-KDR interactions may influence MMP expression in the superficial zones of the primate endometrium during the premenstrual phase, and that these interactions play a role in the induction of menstruation.
  98. ncbi In vivo assessment of human vaginal oxygen and carbon dioxide levels during and post menses
    Donna R Hill
    The FemCare Product Development, Minneapolis, Minnesota, USA
    J Appl Physiol 99:1582-91. 2005
    ..These decreases were independent of the type of tampons used and the time of measurement (mid-cycle or during menstruation)...
  99. ncbi Recovery of menstruation after long-term chemotherapy and endocrine therapy in pre-menopausal patients with breast cancer
    Kenichi Sakurai
    Division of Breast and Endocrine Surgery, Department of Surgery, Nihon University School of Medicine, 30 1, Oyaguchi Kamimachi, Itabashi ku, Tokyo 173 8610, Japan
    J Cancer Res Clin Oncol 137:615-20. 2011
    ..However, it remains to be clarified how often patients recover menstruation after long-term LH-RH agonist plus TAM therapy...
  100. pmc Vascular repair after menstruation involves regulation of vascular endothelial growth factor-receptor phosphorylation by sFLT-1
    M D Graubert
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Am J Pathol 158:1399-410. 2001
    Regeneration of the endometrium after menstruation requires a rapid and highly organized vascular response...
  101. ncbi Ovarian steroids, mitogen-activated protein kinases, and/or aspartic proteinases cooperate to control endometrial remodeling by regulating gene expression in the stroma and glands
    Héloïse P Gaide Chevronnay
    Universite Catholique de Louvain, Cell Biology Unit, de Duve Institute, Medical School, B 1200 Brussels, Belgium
    Endocrinology 151:4515-26. 2010
    ..In conclusion, MAPKs and/or aspartic proteinases likely act in concert with EP to locally and specifically control differential expression of genes between degrading and preserved areas of the human endometrium...

Research Grants64

  1. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..Serum levels of estradiol (E2) and P4, as well as the first day of menstruation, will be used as markers of luteal lifespan...
  2. A Novel Target for the Treatment of Endometriosis
    Paul D Crowe; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Endometriosis is a major cause of severe pelvic pain, pain during menstruation, dyspareunia and infertility in women of child-bearing age with an estimated $22 billion cost of diagnosis and treatment ..
  3. The Role of The Histone Epigenome in the Pathophysiology of Endometriosis
    MARICARMEN COLON; Fiscal Year: 2012
    ..These theories include retrograde menstruation, genetic predisposition, immune system disturbances, and environmental exposures2...
  4. Progesterone Action in the Endometrium of Women with Endometriosis
    Steven L Young; Fiscal Year: 2013
    ..Given that P inhibits endometrial proliferation, sets the stage for apoptotic cell death at menstruation, and induces receptivity to embryo implantation, P resistance could contribute to the pathogenesis and ..
  5. Intrinsic Vascular Smooth Muscle Cell Stiffness
    Stephen F Vatner; Fiscal Year: 2013
    ..primates are the best models to study gender differences with aging, since the changes in hormones and menstruation in old female (OF) monkeys parallel those in older human females...
  6. Effects of Continuous versus Cyclic Oral Contraceptives on Mammary Tumor Growth
    PATRICIA ANN MASSO-WELCH; Fiscal Year: 2013
    ..Based on the ability of OC to eliminate menstruation and accompanying side effects, it is not surprising that many of the ~21% of adult women in the US who are ..
  7. The effect of the penile microbiome on BV, GUD, and genital epithelial trauma
    SUPRIYA DINESH MEHTA; Fiscal Year: 2013
    ..If specific behaviors - such as sex during a woman's menstruation or genital hygiene - are associated with types or amounts of harmful penile bacteria, then behavioral ..
  8. Sex differences in the basic pathophysiology of migraine
    KEVIN CHRISTOPHER BRENNAN; Fiscal Year: 2011
    ..Migraine is more severe during the reproductive years, but improves after menopause. It worsens around menstruation, but improves during pregnancy. This suggests a hormonal role in its origins...
  9. Evolution and Human Reproduction: A longitudinal study of the Dogon of Mali
    BEVERLY ILSE STRASSMANN; Fiscal Year: 2011
    ..primarily by the availability of the author's unique, longitudinal data sets on fertility, mortality, menstruation, health, hormones, growth, and genetics. Sample sizes are large...
  10. Retinoid effects on inflammation and cell growth associated with endometriosis
    Neil Sidell; Fiscal Year: 2012
    ..the uptake and clearance of apoptotic cells and cell debris which seed the peritoneum as a result of retrograde menstruation. We have shown that this receptor is reduced in peritoneal macrophages from women with endometriosis and that ..
  11. Comparative Risk of Endometrial Cancer from Ablation Versus Medical Management
    BRIAN LESLIE STROM; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Abnormal menstruation, often caused by Dysfunctional Uterine Bleeding (DUB), is one of the most common chief complaints to gynecologists and family practices, and is associated with significant ..
  12. ORGANOPHOSPHATE PESTICIDES AND HUMAN REPRODUCTIVE HEALTH
    Xiping Xu; Fiscal Year: 2003
    ..amenorrhea, polymenorrhea, intermenstrual bleeding, prolonged menstrual bleeding, dysmenorrhea, and irregular menstruation); (3) alterations in hormone patterns including reduced estrogen excretion (REE), anovulation, abnormal luteal ..
  13. Monitoring Changes in Cervical Microstructure During Pregnancy
    Mark L Palmeri; Fiscal Year: 2013
    ..branch will be a serial study of quantitative ultrasound parameters at several time points throughout normal menstruation (to establish underlying biological variability), and then normal pregnancy (to describe collagen ..
  14. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2007
    ..However, women with epilepsy often report an increase in seizures at the time of menstruation, a condition referred to as "catamenial epilepsy"...
  15. CHLAMYDIA TRACHOMATIS ENVELOPE COMPONENTS AND VIRULENCE
    JANE RAULSTON; Fiscal Year: 2003
    ..cavity is subject to constant changes in levels of micronutrients such as iron, due to hormonal cycling during menstruation. Endometrial epithelial cells are natural target host cells for infection by chlamydiae...
  16. DDT, Endocrine Disruption and Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2003
    ..history, occupational and environmental factors, and dietary intake; (2) daily diary from each woman reporting menstruation, use of medications, sexual intercourse, contraceptive use, active and passive smoking, alcohol use, and ..
  17. Neuroprotective Effects of Estrogen in Serotonin Neurons
    Jessica Henderson; Fiscal Year: 2007
    ..frequency of depression than men and depressive episodes often correlate with reproductive life events such as menstruation, post-partum, and the onset of menopause...
  18. Estrogen Withdrawal and Dural Mast Cells: Implication for Menstrual Migraine
    Dan Levy; Fiscal Year: 2010
    ..to half of all women migraineurs, the frequency and severity of migraine attacks increase around the time of menstruation. Although the mechanisms underlying these menstrually-related migraines are unclear, the abrupt decline in ..
  19. UTERINE BIOLOGY AND THE PATHOPHYSIOLOGY OF ENDOMETRIOSIS
    Kevin Osteen; Fiscal Year: 2003
    ..attributed to ectopic implantation of fragments of endometrium entering the peritoneal cavity following reflex menstruation. Our central hypothesis is that steroids, acting through local cytokines and growth factors, co-regulate ..
  20. Risk for New onset of Depression in Perimenopausal Women
    Daniel Cramer; Fiscal Year: 2009
    ..Having carefully gathered prospective data on psychiatric disorders and changes in menstruation, we now have a unique opportunity to evaluate the impact of the perimenopausal transition on risk of first ..
  21. NONINVASIVE MEASURES OF STRESS & REPRODUCTIVE STERIODS
    Samuel Wasser; Fiscal Year: 1991
    ..g. menstruation and sex skin turgesence) during natural reproductive cycles and after acute challenges with exogenous hormones (..
  22. STEROID DYNAMICS IN ENDOCRINOLOGY
    ERLIO GURPIDE; Fiscal Year: 1991
    ..are considered to play an important role on dysmenorrhea and dysfunctional bleeding as well as in normal menstruation, implantation and premature or term onset of labor...
  23. PROSPECTIVE STUDY OF STRESS AND MOOD IN CHRONIC HEADACHE
    Edward Blanchard; Fiscal Year: 1999
    ..the menstrual cycle of premenopausal women not on oral contraceptives: time of ovulation and time of onset of menstruation. The investigators believe the interrelations of these variables, HA, mood and stress, are complex...
  24. Botanicals from Central America for Menopause
    Gail Mahady; Fiscal Year: 2005
    Menopause is a universal female experience, and is defined as cessation of menstruation for at least 12 months during the midlife period...
  25. BIOLOGY OF HUMAN UTERINE NK CELLS
    Ashley Moffett; Fiscal Year: 2004
    ..In a non-pregnant cycle the endometrium breaks down at menstruation and a similar process occurs in a failing pregnancy at miscarriage...
  26. Center for Trad.Chinese Medicine & Women's Health
    Fredi Kronenberg; Fiscal Year: 2004
    ..This includes major areas of menstruation, fertility, pregnancy and menopause...
  27. Development of Ketorolac Drug Delivery Device
    Michelle Wilson; Fiscal Year: 2002
    ..or a vaginal ring and is designed to carry the PSI through the vaginal mucosa into uterine circulation during menstruation. This innovative approach will provide effective relief during menses to women who still experience disabling ..
  28. NEW DRUGS FOR THE TREATMENT OF ACNE, REVISED PLAN
    Joseph Dunn; Fiscal Year: 2001
    ..market category is comprised of adult women who are also susceptible to acne during certain stages of their menstruation cycle...
  29. MACROPHAGES, OXIDATION, AND ENDOMETRIOSIS
    Ana Murphy; Fiscal Year: 2003
    ..There is a consensus that retrograde menstruation may account for the presence of endometrial cells in the peritoneal cavity...
  30. ZINC ABSORPTION IN DIABETIC PREGNANT WOMEN
    Janet King; Fiscal Year: 1992
    ..weeks) and late (34-36 weeks) gestation, at the 12th week of lactation, and 6 months following the onset of menstruation. As many of the women as possible will also be studied prior to conception...
  31. BIOBEHAVIORAL HEALTH IN DIVERSE MIDLIFE WOMEN
    Kathryn Lee; Fiscal Year: 2000
    ..distress, and social support) and ethnic/cultural factors will also be examined (premenopausal attitudes toward menstruation, menopause, and aging; meanings and expectations of midlife)...
  32. DEVELOPMENT OF A VAGINAL DRUG DELIVERY SYSTEM
    Michelle Wilson; Fiscal Year: 2000
    ..or a vaginal ring and is designed to carry the PS through the vaginal mucosa into uterine circulation during menstruation. This innovative approach will provide effective relief during menses to women who still experience disabling ..
  33. IMPACT OF PRENATAL EXPOSURE TO DIETHYLSTILBESTROL
    ARTHUR HERBST; Fiscal Year: 1992
    ..To collect prospective data on the menstrual function of the daughters. Menstruation is a function of the endocrine cycle of the female...
  34. Fetal Dioxin Exposure And The Pathology of Endometriosis
    Kevin Osteen; Fiscal Year: 2005
    Endometriosis is a complex and persistent disease, which most often develops following retrograde menstruation and ectopic establishment of endometrial fragments...
  35. ENDOMETRIAL XENOGRAFTS IN IMMUNODEFICIENT MICE
    Ov Slayden; Fiscal Year: 2001
    ..normal endometrial histology, express steroid receptors, show hormonal responsiveness, and undergo normal menstruation in mice? Finally, can the effects of specific drugs on endometrial vascular development and bleeding patterns ..
  36. Menopausal Transition in Women with Spinal Cord Injury
    Claire Kalpakjian; Fiscal Year: 2009
    ..Study 2 will determine the effect of menstruation cessation on physiological outcomes in women with SCI...
  37. Menstrual Health Disparities of Low SES African-America*
    Patricia Koch; Fiscal Year: 2005
    ..The TREMIN is the world's oldest longitudinal study of menstruation throughout women's live...
  38. BRAIN & PLATELET ADRENERGIC RECEPTORS IN DEPRESSION
    Angelos Halaris; Fiscal Year: 1992
    ..Second, it will be determined whether there is a circadian or menstruation-related variation in platelet receptor binding...
  39. Human Endometrial Nitric Oxide: Regulation and Function
    Omid Khorram; Fiscal Year: 2003
    ..expression of eNOS mRNA and protein around the expected time of implantation with a decline just prior menstruation suggests that endometrial eNOS is regulated by sex steroids, and plays a role in implantation process...
  40. AUTOMATIC SHAPE RECOVERY OF HIPPOCAMPUS FROM BRAIN MRI
    Baba Vemuri; Fiscal Year: 2000
    ..A user friendly Visualization and Menstruation Program (VAMP) will be developed as a clinical interface...
  41. Staging Reproductive Aging in Four Cohorts: Issues of Hormone Use Spotting Bias
    Sioban Harlow; Fiscal Year: 2009
    ..Results will facilitate clinical decision making for women and providers relevant to contraception, symptomatic treatment and preventive therapy. ..
  42. Estrogen, Metabolism, Menopause, and Health Outcomes
    MaryFran Sowers; Fiscal Year: 2006
    ..This is a unique opportunity to prospectively integrate lifestyle elements with measures of hormone metabolism pathways into a comprehensive examination of multiple human health effects. ..
  43. HORMONAL CONTROL OF THE FEMALE REPRODUCTIVE TRACT
    Robert Brenner; Fiscal Year: 2004
    ..MMPs are enzymes responsible for the tissue destruction and sloughing associated with menstruation. FLT-1, another VEGF receptor, was also transiently upregulated in the glandular cells which also produce an ..
  44. Control of menstrual bleeding disturbances in women
    Ian Fraser; Fiscal Year: 2006
    ..tetracycline compound, Doxycycline, has strong anti-MMP action and preliminary evidence in a mouse model of menstruation suggests that it may indeed stabilize the endometrium...
  45. Functional Status and the Menopause Transition
    MaryFran R Sowers; Fiscal Year: 2010
    ..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men. ..
  46. A Secular Change in Menstrual Characteristicis of Adult and Midlife Women?
    Sioban D Harlow; Fiscal Year: 2010
    ....
  47. SWAN Sleep Study II - Michigan Center
    MaryFran Sowers; Fiscal Year: 2008
    ..The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. [unreadable] [unreadable] [unreadable]..
  48. Change in Bone, Arthritis, Function: Hormones & Obesity
    MaryFran Sowers; Fiscal Year: 2009
    ....
  49. PDE3 Inhibitors: Selective Blockers of Oocyte Maturation
    Jeffrey Jensen; Fiscal Year: 2007
    ..This approach is expected to provide a foundation for future Phase 1 trials of PDE3 inhibitors in humans. ..
  50. Improving Contraceptive Effectiveness in Obese Women
    Alison B Edelman; Fiscal Year: 2010
    ..abstract_text> ..
  51. Contraceptive efficacy and body weight: Does obesity affect the risk of failure?
    Alison Edelman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  52. DOXYCYCLINE FOR BLEEDING IN PROGESTIN ONLY CONTRACEPTORS
    David Archer; Fiscal Year: 2006
    ..If successful, DOX treatment could become an important adjuvant for treatment of this and possibly other inflammatory disorders effecting reproductive tract tissues. ..
  53. Androgen deficiency and Osteopenia in Anorexia Nervosa
    Karen Miller; Fiscal Year: 2002
    ..In the third phase of the study, we will examine the effects of administering testosterone on bone density and body mass. ..
  54. BRIEF HIV RISK REDUCTION COUNSELING
    Seth Kalichman; Fiscal Year: 2002
    ..Results of the proposed study will guide the allocation of HIV prevention resources in establishing brief and effective HIV risk reduction counseling services for populations vulnerable to HIV infection. ..
  55. HIV TREATMENT ADHERENCE FOR PERSONS WITH LOW-LITERACY
    Seth Kalichman; Fiscal Year: 2002
    ..Results of the proposed research will provide critical information about improving HIV treatment adherence with low-literacy populations that is needed prior to conducting larger and more expensive clinical trials. ..
  56. The Yoga for Hyperkyphosis Trial
    Gail Greendale; Fiscal Year: 2007
    ..At the end of this phase we will again measure study endpoints to assess whether participants have maintained the physical function achieved at the end of the RCT. ..
  57. Oral contraceptives and cytochrome p450 inducers
    Anne Davis; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  58. Gender Violence and HIV Risk Reduction in South Africa
    Leickness Simbayi; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  59. Alcohol and HIV Risk Reduction in South Africa
    Seth Kalichman; Fiscal Year: 2006
    ..Results of the proposed research will provide critical information about the role of alcohol in HIV transmission risks and will offer urgently needed strategies for improving HIV prevention interventions in South Africa. ..
  60. HIV Treatment Adherence/Risk Reduction Integrated
    Seth Kalichman; Fiscal Year: 2009
    ..If shown effective, the intervention model will have implications for community and clinical services for people living with HIV-AIDS. ..
  61. ENDOMETRIOTIC HAPTOGLOBIN ALTERS MACROPHAGE FUNCTION
    KATHY TIMMS; Fiscal Year: 2006
    ..As a result, novel non-invasive strategies for early detection and innovative treatment of endometriosis may be developed that markedly reduce the health burden of this malady. ..