gametogenesis

Summary

Summary: The process of germ cell development from the primordial germ cells to the mature haploid gametes: ova in the female (OOGENESIS) or sperm in the male (SPERMATOGENESIS).

Top Publications

  1. ncbi Large-scale temporal gene expression profiling during gonadal differentiation and early gametogenesis in rainbow trout
    Daniel Baron
    Institut National de la Recherche Agronomique, INRA SCRIBE, IFR 140, Campus de Beaulieu, 35000 Rennes, France
    Biol Reprod 73:959-66. 2005
  2. ncbi Cancer/testis antigens, gametogenesis and cancer
    Andrew J G Simpson
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Cancer 5:615-25. 2005
  3. pmc Transcription of two long noncoding RNAs mediates mating-type control of gametogenesis in budding yeast
    Folkert J van Werven
    David H Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 150:1170-81. 2012
  4. pmc Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cells
    Mark E Gill
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 108:7443-8. 2011
  5. ncbi SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice
    Xu Ding
    Institute of Developmental Biology and Molecular Medicine and School of Life Science, Fudan University, Shanghai 200433, China
    Dev Cell 12:863-72. 2007
  6. pmc Various spatiotemporal expression profiles of anther-expressed genes in rice
    Tokunori Hobo
    Bioscience and Biotechnology Center, Nagoya University, Furocho, Chikusa, Nagoya, 464 8601 Japan
    Plant Cell Physiol 49:1417-28. 2008
  7. pmc Gametogenesis in the Pacific oyster Crassostrea gigas: a microarrays-based analysis identifies sex and stage specific genes
    Nolwenn M Dheilly
    Universite de Caen Basse Normandie, Biologie des Organismes Marins et des Ecosystèmes Associés, IBFA, SFR ICORE, Caen, France
    PLoS ONE 7:e36353. 2012
  8. ncbi MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination
    Malik Lutzmann
    DNA Replication and Genome Dynamics, Institute of Human Genetics, CNRS, 141 rue de la Cardonille, 34396 Montpellier, Cedex 5, France
    Mol Cell 47:523-34. 2012
  9. pmc Separated transcriptomes of male gametophyte and tapetum in rice: validity of a laser microdissection (LM) microarray
    Keita Suwabe
    Graduate School of Life Sciences, Tohoku University, Sendai, 980 8577 Japan
    Plant Cell Physiol 49:1407-16. 2008
  10. pmc Regulation of entry into gametogenesis
    Folkert J van Werven
    David H Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Philos Trans R Soc Lond B Biol Sci 366:3521-31. 2011

Detail Information

Publications243 found, 100 shown here

  1. ncbi Large-scale temporal gene expression profiling during gonadal differentiation and early gametogenesis in rainbow trout
    Daniel Baron
    Institut National de la Recherche Agronomique, INRA SCRIBE, IFR 140, Campus de Beaulieu, 35000 Rennes, France
    Biol Reprod 73:959-66. 2005
    ..to produce a temporal map of fluctuations in mRNA expression of 102 genes during sex differentiation and early gametogenesis in the rainbow trout (Oncorhynchus mykiss)...
  2. ncbi Cancer/testis antigens, gametogenesis and cancer
    Andrew J G Simpson
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Cancer 5:615-25. 2005
    ....
  3. pmc Transcription of two long noncoding RNAs mediates mating-type control of gametogenesis in budding yeast
    Folkert J van Werven
    David H Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 150:1170-81. 2012
    The cell-fate decision leading to gametogenesis is essential for sexual reproduction. In S. cerevisiae, only diploid MATa/α but not haploid MATa or MATα cells undergo gametogenesis, known as sporulation...
  4. pmc Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cells
    Mark E Gill
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 108:7443-8. 2011
    ..of both XX and XY fetuses undergo licensing, an active developmental transition that enables the resultant gametogenesis-competent cells to respond to feminizing or masculinizing cues produced by the fetal ovary or testis and hence ..
  5. ncbi SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice
    Xu Ding
    Institute of Developmental Biology and Molecular Medicine and School of Life Science, Fudan University, Shanghai 200433, China
    Dev Cell 12:863-72. 2007
    ..This study provides genetic evidence that SUN1-telomere interaction is essential for telomere dynamic movement and is required for efficient homologous chromosome pairing/synapsis during mammalian gametogenesis.
  6. pmc Various spatiotemporal expression profiles of anther-expressed genes in rice
    Tokunori Hobo
    Bioscience and Biotechnology Center, Nagoya University, Furocho, Chikusa, Nagoya, 464 8601 Japan
    Plant Cell Physiol 49:1417-28. 2008
    ....
  7. pmc Gametogenesis in the Pacific oyster Crassostrea gigas: a microarrays-based analysis identifies sex and stage specific genes
    Nolwenn M Dheilly
    Universite de Caen Basse Normandie, Biologie des Organismes Marins et des Ecosystèmes Associés, IBFA, SFR ICORE, Caen, France
    PLoS ONE 7:e36353. 2012
    ..2011) representing the oyster transcriptome. The application of this microarray to the study of mollusk gametogenesis should provide a better understanding of the key factors involved in sex differentiation and the regulation of ..
  8. ncbi MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination
    Malik Lutzmann
    DNA Replication and Genome Dynamics, Institute of Human Genetics, CNRS, 141 rue de la Cardonille, 34396 Montpellier, Cedex 5, France
    Mol Cell 47:523-34. 2012
    ..MCM9 and show that deficiency for these genes impairs homologous recombination (HR)-mediated DNA repair during gametogenesis and somatic cells cycles...
  9. pmc Separated transcriptomes of male gametophyte and tapetum in rice: validity of a laser microdissection (LM) microarray
    Keita Suwabe
    Graduate School of Life Sciences, Tohoku University, Sendai, 980 8577 Japan
    Plant Cell Physiol 49:1407-16. 2008
    ..These results indicate that the 44K LM-microarray is a reliable tool to analyze the gene expression profiles of two important cell types in the anther, the microspore/pollen and tapetum...
  10. pmc Regulation of entry into gametogenesis
    Folkert J van Werven
    David H Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Philos Trans R Soc Lond B Biol Sci 366:3521-31. 2011
    b>Gametogenesis is a fundamental aspect of sexual reproduction in eukaryotes...
  11. ncbi Cohesin in gametogenesis
    François McNicoll
    Institute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    Curr Top Dev Biol 102:1-34. 2013
    ....
  12. ncbi cgh-1, a conserved predicted RNA helicase required for gametogenesis and protection from physiological germline apoptosis in C. elegans
    R E Navarro
    Center for Blood Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Development 128:3221-32. 2001
    ..We conclude that cgh-1 and its orthologs may perform conserved functions during gametogenesis, that in C...
  13. ncbi A small-RNA perspective on gametogenesis, fertilization, and early zygotic development
    Déborah Bourc'his
    Institut Curie, CNRS UMR 3215, INSERM U934, 75248 Paris Cedex 05, France
    Science 330:617-22. 2010
    ..as key regulators of extensive epigenetic changes taking place during periconception, which encompasses gametogenesis, fertilization, and early zygotic development...
  14. ncbi bag-of-marbles: a Drosophila gene required to initiate both male and female gametogenesis
    D M McKearin
    Howard Hughes Medical Institution Research Laboratories, Carnegie Institution of Washington, Baltimore, Maryland 21210
    Genes Dev 4:2242-51. 1990
    ..The specific expression of bam RNA within female cystoblasts suggested that it might be involved in the specific cell-cycle alterations that occur during cystocyte divisions...
  15. pmc The conserved transcriptome in human and rodent male gametogenesis
    Frederic Chalmel
    Biozentrum and Swiss Institute of Bioinformatics, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 104:8346-51. 2007
    ..Expression profiling data further identified numerous conserved genes of biological and clinical interest previously unassociated with the mammalian male germ line...
  16. ncbi Induction of gametogenesis in the basal cnidarian Nematostella vectensis(Anthozoa)
    Jens H Fritzenwanker
    Molecular Cell Biology, Zoological Institute, Darmstadt University of Technology, Schnittspahnstrasse 10, 64287 Darmstadt, Germany
    Dev Genes Evol 212:99-103. 2002
    ..We found that a combination of feeding regime, dark-light cycle and temperature shift synergistically induced gametogenesis in adult polyps. Females lay between 100-600 eggs...
  17. ncbi Arabidopsis transcription factor genes NF-YA1, 5, 6, and 9 play redundant roles in male gametogenesis, embryogenesis, and seed development
    Jinye Mu
    State Key Laboratory of Plant Genomics and National Plant Gene Research Center Beijing, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Datun Road, Beijing 100101, China
    Mol Plant 6:188-201. 2013
    ..We found that a gain-of-function mutant of NF-YA1 showed defects in male gametogenesis and embryogenesis...
  18. pmc Protein targeting to the parasitophorous vacuole membrane of Plasmodium falciparum
    Saliha Eksi
    Department of Biology, Loyola University Chicago, Chicago, Illinois, USA
    Eukaryot Cell 10:744-52. 2011
    ..This is the first report to define the amino acid domains required for targeting to the P. falciparum PVM...
  19. ncbi A vasa gene from green mud crab Scylla paramamosain and its expression during gonadal development and gametogenesis
    Yilei Wang
    The Key Laboratory of Science and Technology for Aquaculture and Food Safety, Fisheries College, Jimei University, Xiamen, 361021, China
    Mol Biol Rep 39:4327-35. 2012
    ..Real-time PCR and in situ hybridization were consistent. These findings suggest that Sp-vasa is likely to serve as a useful and specific marker for germ cell development of S. paramamosain...
  20. ncbi Molecular cloning and gene expression of Cg-Foxl2 during the development and the adult gametogenetic cycle in the oyster Crassostrea gigas
    Amine Naimi
    UMR 100 Ifremer, Physiologie et Ecophysiologie des Mollusques Marins, IFR 146 ICORE, IBFA, Universite de Caen Basse Normandie, 14032 Caen, France
    Comp Biochem Physiol B Biochem Mol Biol 154:134-42. 2009
    ..5-month-old spats, a period of development when primordial germ cells may differentiate into germinal stem cells during the first gonadic establishment...
  21. ncbi DMRT genes in vertebrate gametogenesis
    David Zarkower
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, USA
    Curr Top Dev Biol 102:327-56. 2013
    ..In vertebrates, several DM domain genes--DMRT genes--play critical roles in gonadal differentiation or gametogenesis. DMRT1 has the most prominent role and likely regulates testicular differentiation in all vertebrates...
  22. ncbi Male gametogenesis without centrioles
    Maria Giovanna Riparbelli
    University of Siena, Department of Evolutionary Biology, Via A Moro 2, I 53100 Siena, Italy
    Dev Biol 349:427-39. 2011
    ..Here, we have analyzed male gametogenesis in DSas-4 Drosophila mutants and we have reported that spindle alignment and asymmetric divisions are properly ..
  23. ncbi DNA repair mechanisms and gametogenesis
    W M Baarends
    Department of Endocrinology and Reproduction, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Reproduction 121:31-9. 2001
    In mammals, there is a complex and intriguing relationship between DNA repair and gametogenesis. DNA repair mechanisms are involved not only in the repair of different types of DNA damage in developing germline cells, but also take part ..
  24. ncbi Epigenetic transitions in germ cell development and meiosis
    Satya K Kota
    Institute of Molecular Genetics, CNRS UMR5535 and University of Montpellier I and II, 1919 Route de Mende, 34293 Montpellier, France
    Dev Cell 19:675-86. 2010
    ..Here, we review epigenetic transitions during gametogenesis and discuss novel insights from animal and human studies.
  25. pmc SLOW WALKER2, a NOC1/MAK21 homologue, is essential for coordinated cell cycle progression during female gametophyte development in Arabidopsis
    Na Li
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Plant Physiol 151:1486-97. 2009
    Morphogenesis requires the coordination of cell growth, division, and cell differentiation. Female gametogenesis in flowering plants, where a single haploid spore undergoes continuous growth and nuclear division without cytokinesis to ..
  26. pmc SWITCH1 (SWI1): a novel protein required for the establishment of sister chromatid cohesion and for bivalent formation at meiosis
    R Mercier
    Station de Genetique et d Amelioration des plantes, Institut National de la Recherche Agronomique, Route de Saint Cyr, 78026 Versailles Cedex, France
    Genes Dev 15:1859-71. 2001
    ..Thus, SWI1 appears to be a novel protein involved in chromatid cohesion establishment and in chromosome structure during meiosis, but with clear differences between male and female meiosis...
  27. pmc Transfer of plastid DNA to the nucleus is elevated during male gametogenesis in tobacco
    Anna E Sheppard
    School of Molecular and Biomedical Science, University of Adelaide, South Australia 5005, Australia
    Plant Physiol 148:328-36. 2008
    ..The results suggest a new explanation for the occurrence of uniparental inheritance in eukaryotes...
  28. ncbi Regulation of the rate of asexual growth and commitment to sexual development by diffusible factors from in vitro cultures of Plasmodium falciparum
    Mike Dyer
    Peter Medawar Building for Pathogen Research, Department of Zoology, University of Oxford, Oxford, United Kingdom
    Am J Trop Med Hyg 68:403-9. 2003
    ..falciparum, the sexual pathway of development is the default, and that constitutive repression of the sexual pathway permits asexual multiplication to occur in the bloodstream of the human host...
  29. ncbi Differential expression of two gamma-tubulin isoforms during gametogenesis and development in Drosophila
    P G Wilson
    Department of Developmental Biology, Stanford University School of Medicine, California 94305, USA
    Dev Biol 184:207-21. 1997
    ..analysis and immunolocalization show that gamma Tub37CD and gamma Tub23C are differentially expressed during gametogenesis and development...
  30. ncbi Disruption of the Arabidopsis SMC4 gene, AtCAP-C, compromises gametogenesis and embryogenesis
    Najeeb U Siddiqui
    Department of Botany, Division of Life Sciences, University of Toronto, 1265 Military Trail, M1C 1A4, Scarborough, ON, Canada
    Planta 223:990-7. 2006
    ..These results reveal a critical role for AtCAP-C during cell division and, unlike our previous studies on the AtCAP-E genes, suggest that no redundant factors for AtCAP-C exist in the Arabidopsis genome...
  31. ncbi Developmental estrogenic exposure in zebrafish (Danio rerio): II. Histological evaluation of gametogenesis and organ toxicity
    Lynn P Weber
    Department of Zoology, Oklahoma State University, 430 Life Sciences West, Stillwater, OK 74078, USA
    Aquat Toxicol 63:431-46. 2003
    ..the present study was to determine concentration-dependent effects of developmental exposure to NP and EE on gametogenesis, as well as gonad, kidney and liver pathology using quantitative histological evaluation of hematoxylin/eosin-..
  32. pmc YAO is a nucleolar WD40-repeat protein critical for embryogenesis and gametogenesis in Arabidopsis
    Hong Ju Li
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, The Chinese Academy of Sciences, Beijing 100101, China
    BMC Plant Biol 10:169. 2010
    In flowering plants, gametogenesis generates multicellular male and female gametophytes. In the model system Arabidopsis, the male gametophyte or pollen grain contains two sperm cells and a vegetative cell...
  33. ncbi Nucleocytoplasmic transport as a driver of mammalian gametogenesis
    C Itman
    Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    Semin Cell Dev Biol 20:607-19. 2009
    ..This review discusses key examples of regulated nucleocytoplasmic transport during mammalian gametogenesis and the mechanisms underpinning these transport events, focusing on examples critical for the establishment of ..
  34. ncbi Toward the genetics of mammalian reproduction: induction and mapping of gametogenesis mutants in mice
    Jeremy O Ward
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Biol Reprod 69:1615-25. 2003
    The genetic control of mammalian gametogenesis is inadequately characterized because of a lack of mutations causing infertility...
  35. pmc The linker histone plays a dual role during gametogenesis in Saccharomyces cerevisiae
    Jessica M Bryant
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mol Cell Biol 32:2771-83. 2012
    ....
  36. ncbi Identification and expression of a factor of the DM family in the oyster Crassostrea gigas
    Amine Naimi
    UMR 100 Ifremer, Physiologie et Ecophysiologie des Mollusques Marins, IFR 146 ICORE, IBFA, Universite de Caen Basse Normandie, 14032 Caen, France
    Comp Biochem Physiol A Mol Integr Physiol 152:189-96. 2009
    ..These results suggest that Cg-DMl may be involved in the development of the gonad and may constitute preliminary clues for future work in order to better understand DM protein evolution...
  37. pmc Identification of male gametogenesis expressed genes from the scallop Nodipecten subnodosus by suppressive subtraction hybridization and pyrosequencing
    Raul Llera-Herrera
    Aquaculture Genetics and Breeding Laboratory, Centro de Investigaciones Biologicas del Noroeste, La Paz, Baja California Sur, Mexico
    PLoS ONE 8:e73176. 2013
    ..subnodosus. In relation to the inactive library, we identified 833 transcripts with functional annotation related to activation of the transcription and translation machinery, as well as to germline control and maintenance. ..
  38. pmc Promiscuous recombination of LoxP alleles during gametogenesis in cornea Cre driver mice
    Daniel Y Weng
    Department of Ophthalmology, University of Cincinnati, Cincinnati, OH 45267 0838, USA
    Mol Vis 14:562-71. 2008
    To examine whether promiscuous Cre/LoxP recombination happens during gametogenesis in double transgenic mice carrying LoxP modified alleles and Cre transgene driven by tissue-specific promoter outside the gonads of adult mice.
  39. ncbi Hypogonadotrophic hypogonadism and diminished gonadal reserve accounts for dysfunctional gametogenesis in thalassaemia patients with iron overload presenting with infertility
    Rekha Bajoria
    Institute for Women s Health, University College London, London, UK
    Hemoglobin 35:636-42. 2011
    ..Better outcome is expected in females than males. We report the first two cases of paternity following IVF and ICSI in β-TM patients with HH...
  40. ncbi Reproductive traits of the cold-seep symbiotic mussel Idas modiolaeformis: gametogenesis and larval biology
    Sylvie Marylène Gaudron
    Universite Pierre et Marie Curie Paris VI, CNRS, UMR, Systématique, Adaptations, Evolution, AMEX, France
    Biol Bull 222:6-16. 2012
    ..Diameters of the two larval shells are in the range of sizes reported for mytilids, with a PII size between that of the shallow Mytilus edulis and that of the cold-seep mussel "Bathymodiolus" childressi...
  41. ncbi Influence of plankton concentration on gametogenesis and spawning of the black lip pearl oyster Pinctada margaritifera in Ahe atoll lagoon (Tuamotu Archipelago, French polynesia)
    Jonathan Fournier
    IFREMER, Centre du Pacifique, BP 7004, 98719 Taravao, Tahiti, French Polynesia
    Mar Pollut Bull 65:463-70. 2012
    ..We found that (i) plankton concentration fluctuations were mainly related to wind regime, (ii) gametogenesis rate was mainly related to plankton concentration, (iii) spawning occurred when maximal gonad storage was ..
  42. pmc The structural complexity of the human BORIS gene in gametogenesis and cancer
    Elena M Pugacheva
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 5:e13872. 2010
    ..While recent studies demonstrated that BORIS is a transcriptional activator of testis-specific genes, little is generally known about its biological and molecular functions...
  43. pmc Gametogenesis in the Chlamydomonas reinhardtii minus mating type is controlled by two genes, MID and MTD1
    Huawen Lin
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Genetics 176:913-25. 2007
    ..We report studies on MID expression patterns during gametogenesis and on a second gene unique to the MT(-) locus, MTD1. Vegetative cells express basal levels of MID...
  44. ncbi Oyster sex determination is influenced by temperature - first clues in spat during first gonadic differentiation and gametogenesis
    Christelle Santerre
    Normandie Univ, France
    Comp Biochem Physiol A Mol Integr Physiol 165:61-9. 2013
    ..In parallel, gonadic differentiation, gametogenesis and sex ratios were assessed by histology at each of these temperatures...
  45. ncbi The trophinin gene encodes a novel group of MAGE proteins, magphinins, and regulates cell proliferation during gametogenesis in the mouse
    S Saburi
    Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 276:49378-89. 2001
    ..of the male and female germ cells, whereas these proteins are translocated to the nucleus at a specific stage of gametogenesis. These results strongly suggest that magphinins regulate cell proliferation during gametogenesis in the mouse.
  46. pmc Heat shock protein expression during gametogenesis and embryogenesis
    A Neuer
    Department of Obstetrics and Gynecology, University of Witten Herdecke, Dortmund, Germany
    Infect Dis Obstet Gynecol 7:10-6. 1999
    ..In this report, the production of hsps in gametogenesis and early embryo development is described...
  47. pmc The central cell plays a critical role in pollen tube guidance in Arabidopsis
    Yan hong Chen
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Plant Cell 19:3563-77. 2007
    ..Expression of CCG in the central cell alone is sufficient to restore the normal pollen tube guidance phenotype, demonstrating that the central cell plays a critical role in pollen tube guidance...
  48. pmc Systematic screen reveals new functional dynamics of histones H3 and H4 during gametogenesis
    Jerome Govin
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genes Dev 24:1772-86. 2010
    ..We undertook a systematic investigation of chromatin reorganization during gametogenesis, using the model eukaryote Saccharomyces cerevisiae to examine sporulation, which has strong similarities with ..
  49. ncbi The flagellum in malarial parasites
    R E Sinden
    The Malaria Centre, The Department of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom
    Curr Opin Microbiol 13:491-500. 2010
    ....
  50. ncbi Effects of estrogen exposure in mussels, Mytilus edulis, at different stages of gametogenesis
    Corina M Ciocan
    Department of Biology and Environmental Science, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, UK
    Environ Pollut 158:2977-84. 2010
    ..increase in VTG and ER2 mRNA expression was observed in mussels exposed to estrogens at the early stage of gametogenesis. In contrast, mature mussels displayed no statistically significant change in the VTG or ER2 mRNA expression...
  51. ncbi Mutations in the Arabidopsis nuclear-encoded mitochondrial phage-type RNA polymerase gene RPOTm led to defects in pollen tube growth, female gametogenesis and embryogenesis
    Xiao Yun Tan
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, PR China
    Plant Cell Physiol 51:635-49. 2010
    ..All these data indicate that RPOTm is important for normal pollen tube growth, female gametogenesis and embryo development, and has distinct genetic and molecular roles in plant development, which cannot be ..
  52. ncbi Arabidopsis glucan synthase-like 10 functions in male gametogenesis
    Lijun Huang
    Division of Applied Life Science BK21 program, Graduate School of Gyeongsang National University, Jinju, Republic of Korea
    J Plant Physiol 166:344-52. 2009
    ..gsl10 mutant microspores failed to enter into mitosis. Unlike the previously described functions of GSL1, GSL2 and GSL5, GSL10 involves an independent process of pollen development at the mitotic division stage...
  53. ncbi Non-traditional roles of ubiquitin-proteasome system in fertilization and gametogenesis
    Naoyuki Sakai
    Department of Biochemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Int J Biochem Cell Biol 36:776-84. 2004
    Fertilization and gametogenesis are key events in sexual reproduction...
  54. ncbi Roles of heat shock factors in gametogenesis and development
    Ryma Abane
    CNRS, UMR7216 Epigenetics and Cell Fate, Paris, France
    FEBS J 277:4150-72. 2010
    ..Besides their roles in the stress response, heat shock factors perform crucial roles during gametogenesis and development in physiological conditions...
  55. pmc Genetic analysis of female gametophyte development and function
    G N Drews
    Department of Biology, University of Utah, Salt Lake City 84112, USA
    Plant Cell 10:5-17. 1998
    ....
  56. pmc Drosophila importin alpha1 performs paralog-specific functions essential for gametogenesis
    R Ratan
    Biology Department, Trinity College, Hartford, Connecticut 06106, USA
    Genetics 178:839-50. 2008
    ..null flies developed normally to adulthood (with a minor wing defect) but were sterile with defects in gametogenesis. The Dalpha1 mutant phenotypes were rescued by Dalpha1 transgenes, but not by Dalpha2 or Dalpha3 transgenes...
  57. pmc Disruption of a Plasmodium falciparum cyclic nucleotide phosphodiesterase gene causes aberrant gametogenesis
    Cathy J Taylor
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Mol Microbiol 69:110-8. 2008
    ..GC activity in parasites having undergone disruption of the PfGCbeta gene had no significant effect on gametogenesis. By contrast, decreased cGMP-PDE activity during gametocyte development owing to disruption of the PfPDEdelta ..
  58. pmc MAA3 (MAGATAMA3) helicase gene is required for female gametophyte development and pollen tube guidance in Arabidopsis thaliana
    Kentaro K Shimizu
    Department of Botany, Graduate School of Science, Kyoto University, Kitashirakawa Oiwake, Sakyo, Kyoto, 606 8502 Japan
    Plant Cell Physiol 49:1478-83. 2008
    ..The MAA3 gene encodes a homolog of yeast Sen1 helicase, required for RNA metabolism. It is suggested that MAA3 may regulate RNA molecules responsible for nucleolar organization and pollen tube guidance...
  59. ncbi Expressed sequence tag analysis of Lilium longiflorum generative cells
    Takashi Okada
    Australian Research Centre of Excellence for Integrative Legume Research, Institute of Land and Food Resources, The University of Melbourne, Parkville, Victoria 3010, Australia
    Plant Cell Physiol 47:698-705. 2006
    ..related to the ubiquitin system were abundant, suggesting the key role of ubiquitin-dependent proteolysis in gametogenesis. A total of 168 and 129 non-redundant lily generative cell ESTs showed significant similarity to maize sperm ..
  60. pmc Plasmodium malariae infection boosts Plasmodium falciparum gametocyte production
    F Ellis McKenzie
    Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Trop Med Hyg 67:411-4. 2002
    ..falciparum by prior or concurrent P. malariae infection but diminished or unaffected in P. malariae by P. falciparum. Conversely, asexual-form production was diminished in P. malariae but unaffected in P. falciparum...
  61. ncbi The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis
    M Ruggiu
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Nature 389:73-7. 1997
    ..Disruption of the Dazla gene leads to loss of germ cells and complete absence of gamete production, demonstrating that Dazla is essential for the differentiation of germ cells...
  62. ncbi Developmental expression of ASG- 1 during gametogenesis in apomictic guinea grass (Panicum maximum)
    Lanzhuang Chen
    Gene Research Center, Miyazaki University, Japan
    J Plant Physiol 162:1141-8. 2005
    ..ISH) to monitor the expression of apomixis-specific gene-1 (ASG-1, GenBank accession number AB000809) during gametogenesis in obligate-sexual and facultative-apomictic (aposporic) genotypes of guinea grass (Panicum maximum)...
  63. ncbi Temporal and spatial differential expression of chicken germline-specific proteins cDAZL, CDH and CVH during gametogenesis
    Gakushi Kito
    Laboratory of Reproductive Physiology and Biotechnology, Department of Animal and Marine Bioresource Sciences, Faculty of Agriculture, Graduate School Kyushu University, Fukuoka, Japan
    J Reprod Dev 56:341-6. 2010
    ..in Azoospermia-Like (DAZL) protein coded by Dazl gene is a germline-specific RNA-binding protein essential for gametogenesis in vertebrates, and the chicken Dazl gene has also been identified in primordial germ cells (PGCs)...
  64. ncbi Targeting and sequestration of truncated Pfs230 in an intraerythrocytic compartment during Plasmodium falciparum gametocytogenesis
    Saliha Eksi
    Department of Biology, Loyola University Chicago, Chicago, IL 60626, USA
    Mol Microbiol 44:1507-16. 2002
    ..Although both sets of clones undergo gametogenesis and produce morphologically normal gametes, neither truncated Pfs230 is located on the surface of the gamete...
  65. ncbi The role of osmiophilic bodies and Pfg377 expression in female gametocyte emergence and mosquito infectivity in the human malaria parasite Plasmodium falciparum
    Tania F de Koning-Ward
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia
    Mol Microbiol 67:278-90. 2008
    ..less efficient both in vitro and in vivo in their emergence from the erythrocytes upon induction of gametogenesis, a process whose timing is critical for fertilization with the short-lived male gamete...
  66. pmc Meiotic pairing and imprinted X chromatin assembly in Caenorhabditis elegans
    Christopher J Bean
    Biology Department, 1510 Clifton Road, Rollins Research Center, Emory University, Atlanta, Georgia 30322, USA
    Nat Genet 36:100-5. 2004
    ..or whole chromosomes, as in imprinted X-chromosome inactivation in mammals, is established and reset during gametogenesis; defects in this process in the parent can result in disease in the offspring...
  67. ncbi Genetic and molecular identification of genes required for female gametophyte development and function in Arabidopsis
    Gabriela C Pagnussat
    Section of Plant Biology, University of California, One Shields Avenue, Davis, CA 95616, USA
    Development 132:603-14. 2005
    ..These results provide a first comprehensive overview of the genes and gene products involved in female gametophyte development and function within a flowering plant...
  68. pmc CYP85A1 is required for the initiation of female gametogenesis in Arabidopsis thaliana
    Victor Hugo Pérez-España
    Grupo de Desarrollo Reproductivo y Apomixis, Departamento de Ingeniería Genética y Laboratorio Nacional de Genómica para Biodiversidad, CINVESTAV Irapuato, Km 9 6 Libramiento Norte Carretera Irapuato León, Irapuato, Guanajuato, Mexico
    Plant Signal Behav 6:321-6. 2011
    ..Our results indicate that BR biosynthesis is required for the initiation of megagametogenesis in Arabidopsis...
  69. pmc Timing of transcriptional quiescence during gametogenesis is controlled by global histone H3K4 demethylation
    Mengshu Xu
    Department of Molecular Genetics, University of Toronto, Toronto M5S 1A8, Canada
    Dev Cell 23:1059-71. 2012
    Gametes are among the most highly specialized cells produced during development. Although gametogenesis culminates in transcriptional quiescence in plants and animals, regulatory mechanisms controlling this are unknown...
  70. ncbi Up-regulation of gonadotropin mRNA-expression at the onset of gametogenesis in the roach (Rutilus rutilus): evidence for an important role of brain-type aromatase (cyp19a1b) in the pituitary
    Achim Trubiroha
    Department of Ecophysiology and Aquaculture, Leibniz Institute of Freshwater Ecology and Inland Fisheries, Mueggelseedamm 310, D 12587 Berlin, Germany
    Gen Comp Endocrinol 178:529-38. 2012
    ..of reproduction in adult roach (Rutilus rutilus) from Lake Grosser Mueggelsee (Berlin, Germany) during natural gametogenesis. Fish of both sexes were sampled in monthly intervals between April and August in order to cover the onset of ..
  71. ncbi [Biology of man-mosquito Plasmodium transmission]
    V Robert
    IRD UR 077 paludisme afro tropical et Groupe de recherche sur le paludisme de l Institut Pasteur de Madagascar, B P 1274 Antananarivo 101, Madagascar
    Bull Soc Pathol Exot 96:6-20. 2003
    ....
  72. ncbi Arabidopsis CDKA;1, a cdc2 homologue, controls proliferation of generative cells in male gametogenesis
    Hidekazu Iwakawa
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Takayama 8916 5, Ikoma, Nara 630 0101, Japan
    Plant J 45:819-31. 2006
    ..Thus, CDKA;1 is essential for cell division of the generative cell in male gametogenesis.
  73. ncbi LINCing the nuclear envelope to gametogenesis
    Martin P Kracklauer
    Department of Physiology, Wayne State University Medical School, Detroit, Michigan, USA
    Curr Top Dev Biol 102:127-57. 2013
    b>Gametogenesis combines two important features: reduction of the genome content from diploid to haploid by carefully partitioning chromosomes, and the subsequent differentiation into fertilization-competent gametes, which in males is ..
  74. pmc Conditional Tek promoter-driven deletion of arginyltransferase in the germ line causes defects in gametogenesis and early embryonic lethality in mice
    Nicolae Adrian Leu
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 4:e7734. 2009
    ..had lethality at early post-implantation stages that could be explained only by a previously unknown defect in gametogenesis originating from Tek-driven Ate1 deletion in premeiotic germs cells...
  75. ncbi Gonad morphology, gametogenesis, and reproductive modes in fishes of the tribe Starksiini (Teleostei, Blenniiformes)
    Lev Fishelson
    Deparment of Zoology, Tel Aviv University, Tel Aviv 69978, Israel
    J Morphol 274:496-511. 2013
    ....
  76. ncbi Sexually dimorphic expression of foxl2 during gametogenesis in scallop Chlamys farreri, conserved with vertebrates
    Xiao Ling Liu
    Key Laboratory of Marine Genetics and Breeding Ocean University of China, Ministry of Education, Qingdao 266003, People s Republic of China
    Dev Genes Evol 222:279-86. 2012
    ..Our data imply that Cf-foxl2 is expressed in a sexually dimorphic pattern at the RNA level, which is conserved with vertebrates...
  77. pmc A mitogen-activated protein kinase regulates male gametogenesis and transmission of the malaria parasite Plasmodium berghei
    Radha Rangarajan
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    EMBO Rep 6:464-9. 2005
    ..Consistent with this result, transmission of mutant parasites to mosquitoes is grossly impaired. This finding identifies a crucial role for a MAPK pathway in malaria transmission...
  78. ncbi Epigenetic reprogramming of the male genome during gametogenesis and in the zygote
    S Rousseaux
    INSERM, U823, Grenoble, F 38706 France
    Reprod Biomed Online 16:492-503. 2008
    ..The functional implications of male post-meiotic and post-fertilization genome reprogramming are not well known, but there is experimental evidence to show that it affects early embryonic development...
  79. ncbi The Caenorhabditis elegans eukaryotic initiation factor 5A homologue, IFF-1, is required for germ cell proliferation, gametogenesis and localization of the P-granule component PGL-1
    Momoyo Hanazawa
    Molecular Genetics Research Laboratory, University of Tokyo, Science Building No 7, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mech Dev 121:213-24. 2004
    ..nuclei are observed, as revealed by presence of immunoreactivity to the anti-HIM-3 antibody; however, no gametogenesis occurs in the iff-1 gonads...
  80. ncbi Non-canonical poly(A) polymerase in mammalian gametogenesis
    Shin ichi Kashiwabara
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba Science City, Ibaraki, Japan
    Biochim Biophys Acta 1779:230-8. 2008
    ..lengthening, maintenance, and shortening of poly(A) tails in the cytoplasm are all essential for modulation of gametogenesis. Here we focus on the functional roles of mouse Tpap and Gld-2 in spermatogenesis and oocyte maturation, ..
  81. ncbi Glycogen synthase kinase 3 has a proapoptotic function in Hydra gametogenesis
    Fabian Rentzsch
    Institute of Zoology, University of Darmstadt, Germany
    Dev Biol 278:1-12. 2005
    ..In Hydra, HyGSK3 transcripts are strongly upregulated during gametogenesis. Treatment of female polyps with the GSK3 inhibitors lithium and alsterpaullone prevents the differentiation ..
  82. ncbi Influence of disseminated neoplasia, trematode infections and gametogenesis on surfacing and mortality in the cockle Cerastoderma edule
    E Morgan
    University College Cork, Cork, Ireland
    Dis Aquat Organ 98:73-84. 2012
    ..A combination of the presence of neoplasia and trematodes, along with stress related to spawning, may immunocompromise the cockless, causing the animals to surface and become moribund...
  83. ncbi Expression profiling of Wnt signaling genes during gonadal differentiation and gametogenesis in rainbow trout
    B Nicol
    INRA, UR1037 SCRIBE, IFR140, Ouest genopole, Rennes, France
    Sex Dev 5:318-29. 2011
    ..expression of Wnt signaling genes was investigated in rainbow trout during gonadal differentiation and gametogenesis. Multiple Wnt pathway genes were expressed and exhibited distinct expression patterns...
  84. ncbi DNA methylation of germ-cell-specific basic helix-loop-helix (HLH) transcription factors, Sohlh2 and Figlα during gametogenesis
    Bo Pan
    Laboratory of Germ Cell Biology, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, People s Republic of China
    Mol Hum Reprod 17:550-61. 2011
    ..Germ-cell-specific transcription factors, Sohlh2 and Figla, play key roles in gametogenesis. To elucidate whether an epigenetic mechanism is involved in the controlled expression of Sohlh2 and Figlα, ..
  85. pmc Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase
    Louisa McRobert
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Biol 6:e139. 2008
    ..A mosquito-derived molecule, xanthurenic acid (XA), can trigger gametogenesis, but the signalling events controlling this process in the human malaria parasite Plasmodium falciparum remain ..
  86. ncbi Evolutionary aspects of cellular communication in the vertebrate hypothalamo-hypophysio-gonadal axis
    Riccardo Pierantoni
    Department of Experimental Medicine, II University of Naples, Italy
    Int Rev Cytol 218:69-141. 2002
    ..In fact, different anatomical organization permits access to tissues not readily approachable in mammals...
  87. ncbi Differential expression of two vasa/PL10-related genes during gametogenesis in the special model system Rana
    Silvia Marracci
    Laboratorio di Biologia Cellulare e dello Sviluppo, Dipartimento di Biologia, Universita di Pisa, Via Carducci 13, 56010 Ghezzano, Pisa, Italy
    Dev Genes Evol 217:395-402. 2007
    ..Both genes were expressed during the early stages of gametogenesis of R. ridibunda, R. lessonae, and their natural hybrid R. esculenta. RlVlg expression was germline specific...
  88. pmc Function of the A-type cyclins during gametogenesis and early embryogenesis
    Debra J Wolgemuth
    Department of Genetics and Development, Columbia University Medical Center, Russ Berrie 608, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Results Probl Cell Differ 53:391-413. 2011
    ..In contrast, cyclin A2-deficiency is marked by early embryonic lethality; thus, understanding the function of cyclin A2 in the adult germ line awaits conditional mutagenesis or other approaches to knock down its expression...
  89. ncbi Does the shape of Plasmodium falciparum gametocytes have a function?
    Mathieu Nacher
    Shoklo Malaria Research Unit, Mae Sod, Thailand
    Med Hypotheses 62:618-9. 2004
    ..The asymmetric curvature of gametocytes may tend to present gametocytes perpendicularly to the axis of the blood flow, thus increasing their chance to be retained and accumulate where they can be absorbed by the vector...
  90. ncbi Chlorpyrifos exposure reduces reproductive capacity owing to a damaging effect on gametogenesis in the nematode Caenorhabditis elegans
    Qin Li Ruan
    Key Laboratory of Environmental Medicine Engineering in Ministry of Education, Department of Occupational and Environmental Health, School of Public Health, Southeast University, Nanjing, China
    J Appl Toxicol 32:527-35. 2012
    ..Alterations in the expression patterns of genes involved in gametogenesis may explain the corresponding changes in gametogenesis in nematodes exposed to chlorpyrifos...
  91. pmc Comprehensive transcriptome analysis of phytohormone biosynthesis and signaling genes in microspore/pollen and tapetum of rice
    Ko Hirano
    Bioscience and Biotechnology Center, Nagoya University, Nagoya, 464 8601 Japan
    Plant Cell Physiol 49:1429-50. 2008
    ....
  92. ncbi Stimulatory effects of insulin-like growth factor 1 on expression of gonadotropin subunit genes and release of follicle-stimulating hormone and luteinizing hormone in masu salmon pituitary cells early in gametogenesis
    Shunji Furukuma
    Department of Animal and Marine Bioresource Science, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812 8581, Japan
    Zoolog Sci 25:88-98. 2008
    ..of this study was to determine if IGF-I directly stimulates synthesis and release of GTH at an early stage of gametogenesis. The effects of IGF-I on expression of genes encoding glycoprotein alpha (GPalpha), follicle-stimulating ..
  93. pmc Arabidopsis thaliana MIRO1 and MIRO2 GTPases are unequally redundant in pollen tube growth and fusion of polar nuclei during female gametogenesis
    Christopher G Sørmo
    Department of Biology, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    PLoS ONE 6:e18530. 2011
    ....
  94. pmc Maintenance of DNA methylation during the Arabidopsis life cycle is essential for parental imprinting
    Pauline E Jullien
    Chromatin and Reproduction Group, Temasek Lifesciences Laboratory, National University of Singapore, Singapore 117604, Republic of Singapore
    Plant Cell 18:1360-72. 2006
    ..FIS2 imprinting requires the maintenance of DNA methylation throughout the plant life cycle, including male gametogenesis and endosperm development...
  95. ncbi Heterochromatin endoreduplication prior to gametogenesis and chromatin diminution during early embryogenesis in Mesocyclops edax (Copepoda: Crustacea)
    Ellen M Rasch
    Department of Anatomy and Cell Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614 0582, USA
    J Morphol 269:387-97. 2008
    ..We also report the robust uptake of 3H-thymidine by germ cells prior to gametogenesis in this species...
  96. ncbi Lanosterol 14alpha-demethylase and MAS sterols in mammalian gametogenesis
    D Rozman
    Medical Center for Molecular Biology, Faculty of Medicine, Institute of Biochemistry, University of Ljubljana, Vrazov trg 2, 1000, Ljubljana, Slovenia
    Mol Cell Endocrinol 187:179-87. 2002
    ..Potential in vivo roles of FF-MAS and T-MAS in fertilization are discussed...
  97. ncbi Expression of rck/p54, a DEAD-box RNA helicase, in gametogenesis and early embryogenesis of mice
    Kenji Matsumoto
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu, Japan
    Dev Dyn 233:1149-56. 2005
    ..In the current study, we investigated the expression of rck/p54 in mouse gametogenesis and early embryogenesis...
  98. pmc A novel ATM-dependent X-ray-inducible gene is essential for both plant meiosis and gametogenesis
    Philip J Dean
    Centre for Plant Sciences, University of Leeds, Leeds, UK
    Plant J 58:791-802. 2009
    ..Yeast two-hybrid studies identified an interaction between XRI1 and a novel component of the Arabidopsis MND1/AHP2 complex, indicating possible requirements for XRI1 in meiotic DNA repair...
  99. pmc Pollen development and fertilization in Arabidopsis is dependent on the MALE GAMETOGENESIS IMPAIRED ANTHERS gene encoding a type V P-type ATPase
    Mia Kyed Jakobsen
    Department of Plant Biology, The Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    Genes Dev 19:2757-69. 2005
    ..we describe a novel member of the eukaryotic type V subfamily (P(5)) of P-type ATPase cation pumps, the MALE GAMETOGENESIS IMPAIRED ANTHERS (MIA) gene...
  100. pmc Two Arabidopsis phragmoplast-associated kinesins play a critical role in cytokinesis during male gametogenesis
    Yuh Ru Julie Lee
    Section of Plant Biology, University of California, Davis, California 95616, USA
    Plant Cell 19:2595-605. 2007
    ..Furthermore, we conclude that Kinesin-12 members serve as dynamic linkers of the plus ends of antiparallel microtubules in the phragmoplast...
  101. ncbi CLO/GFA1 and ATO are novel regulators of gametic cell fate in plants
    Cordula Moll
    ZMBP Developmental Genetics, University of Tubingen, D 72076 Tubingen, Germany
    Plant J 56:913-21. 2008
    ..Our results thus establish that the restriction of gametic cell fate is specifically coupled to the function of various core spliceosomal components...

Research Grants65

  1. Functional Analysis of the Dual Specificity Kinase NEK1 in Mammalian Meiosis
    JOANNA KIM HOLLOWAY; Fiscal Year: 2011
    ..project with a strong background in both molecular biology and cytogenetics (with an emphasis on mammalian gametogenesis);my goal is to strengthen my proteomics skills in order to execute this project and move toward independent ..
  2. Analysis of the role of the VRK1 protein kinase in mammalian fertility
    Paula Traktman; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Gametogenesis is a highly regulated process that has profound importance for the maintenance of animal species...
  3. BMP signaling in vertebrate development
    Ken W Y Cho; Fiscal Year: 2013
    ..The roles of BMPs have diverged in evolution and include the control of gametogenesis, early embryonic development, cell differentiation/apoptosis, and tissue homeostasis in the adult...
  4. Transcriptional control of pituitary gonadotropin genes
    Varykina G Thackray; Fiscal Year: 2013
    ..Production of gonadotropin hormones critical for steroidogenesis, gametogenesis and ovulation is also disturbed in these disorders...
  5. Functional Analysis of the Dual Specificity Kinase NEK1 in Mammalian Meiosis
    JOANNA KIM HOLLOWAY; Fiscal Year: 2013
    ..project with a strong background in both molecular biology and cytogenetics (with an emphasis on mammalian gametogenesis);my goal is to strengthen my proteomics skills in order to execute this project and move toward independent ..
  6. Mechanisms of Arsenic-Induced Developmental Toxicity
    Lisa Bain; Fiscal Year: 2009
    ..mummichogs, our laboratory has shown developmental abnormalities in offspring exposed to 230ppb arsenic during gametogenesis, which correlated with an upregulation of genes involved the musculature, such as myosin light chain 2, ..
  7. Oncogenic Kit receptor signaling in vivo
    Peter Besmer; Fiscal Year: 2012
    ..The Kit receptor encoded at the murine W locus functions in hematopoiesis, gametogenesis, melanogenesis and gut motility...
  8. Kinetics of Chromosome Synapsis During Meiosis
    Jennifer C Fung; Fiscal Year: 2013
    ..during meiosis will enable greater understanding of the intricate pathways that contribute to normal gametogenesis and fertility. During prophase I, homologous chromosomes pair and then synapse...
  9. Role of Cyclin A's in mammalian gametogenesis
    Debra J Wolgemuth; Fiscal Year: 2013
    ....
  10. Biochemistry of recombination in gametogenesis
    Wayne P Wahls; Fiscal Year: 2010
    Meiosis, a central part of gametogenesis, is essential for sexual reproduction. In meiosis chromosomes replicate once, then segregate twice to produce haploid meiotic products...
  11. Regulation of meiotic recombination and chromosome segregation in mammals
    KAREN MICHELE BERKOWITZ; Fiscal Year: 2013
    ..that Chtf18 is expressed throughout the mammalian male and female germline, suggesting a role for Chtf18 in gametogenesis. Recently, we demonstrated a role for Chtf18 in male fertility and meiosis in vivo...
  12. GnRH-Regulated Transcriptome in the Gonadotrope
    Djurdjica Coss; Fiscal Year: 2010
    ..b>Gametogenesis and steroidogenesis in both sexes are controlled by these two hormones, follicle-stimulating hormone (FSH) and ..
  13. A Mouse Model for Human Gastrointestinal Stromal Tumor
    Peter Besmer; Fiscal Year: 2013
    ..The KIT receptor has critical roles in several cell systems including hematopoiesis, the pigmentary system, gametogenesis, and in pacemaker cells of the gastrointestinal tract...
  14. Transcriptome-wide Polyadenylation Site Use in Male Germ Cell Transcripts
    BECKY SARTINI; Fiscal Year: 2013
    ..Scientific Vision Workshop on Reproduction including contributing to a molecular atlas of fundamental male gametogenesis by using current high throughput sequencing and bioinformatics...
  15. Molecular Mechanisms of Genetic Recombination in Mammals
    Galina Petukhova; Fiscal Year: 2013
    ..It results from errors in the segregation of homologous chromosomes (homologs) during gametogenesis. The proper segregation is ensured by meiotic recombination...
  16. Function of SIRT1 in Growth and Reproduction
    Leonard P Guarente; Fiscal Year: 2013
    ..The central role of SIRT1 in driving reproduction begs the question whether this sirtuin also controls gametogenesis in a cell autonomous manner. Preliminary findings say it does...
  17. TRANSLATIONAL CONTROL DURING MURINE SPERMATOGENESIS
    Robert E Braun; Fiscal Year: 2010
    ..b>Gametogenesis involves the production of highly specialized cells with unique organelles designed to accomplish the union of ..
  18. The Role of AP-1 in the Gonadotrope
    Djurdjica Coss; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Gametogenesis in females is controlled by follicle-stimulating hormone (FSH) from the pituitary, which is, in turn, regulated by gonadotropin-releasing hormone (GnRH) from the hypothalamus...
  19. MeCP2 regulation on LINE-1 retrotransposition in neurons
    Charles A Thomas; Fiscal Year: 2013
    ..Historically, L1s were thought to only retrotranspose during gametogenesis and in neoplastic processes, but recent studies have shown L1s are extremely active in the mouse, rat, and ..
  20. Investigations of Mouse Interspecies Hybrids
    James M McGrath; Fiscal Year: 2013
    ..RNA's have been found to play a critical role in the oocyte and male germline for embryo development and gametogenesis. One of the roles these RNA's are thought to provide is the control of transposable elements (TE) which ..
  21. Nonpeptide Kisspeptin Antagonists for PCOS and HPG axis control
    Stephen F Betz; Fiscal Year: 2012
    ..activity dictates a host of biological responses, including gonadal development, puberty, fertility, gametogenesis and sex hormone production...
  22. The Role of IME4 and IME2 in Drosophila Gametogenesis
    CINTIA FABIANA HONGAY; Fiscal Year: 2010
    ..Phase II: Aim 3: To investigate the role of Ime4 as an RNA methyltransferase in gametogenesis and identify its targets for this modification...
  23. Functions of cohesin SMC1Beta in mammalian meiotic chromosome structure and dynam
    Ekaterina Revenkova; Fiscal Year: 2010
    Sister chromatid cohesion and DNArecombination are at the heart of meiosis, which is a key process for gametogenesis. Maintenance ofgenome integrity during gametogenesis is of utmost medical importance, considering the extraordinarily ..
  24. Molecular Regulation of Mammalian Meiosis
    Kenneth Paigen; Fiscal Year: 2013
    ..goals: a) Comprehensively define PRDM9's regulatory functions in recombination, transcription, and gametogenesis;b) Define the role of PRDM9 in regulation of meiosis by identifying and characterizing its interactions with ..
  25. EPIGENETIC REGULATION IN A CANCER ASSOCIATED REGION
    Michael J Higgins; Fiscal Year: 2012
    ..gene silencing takes place;these analyses will determine whether expression of the ncRNA is required during gametogenesis, and whether the ncRNA is necessary for the maintenance of imprinted expression once it is established...
  26. Role of Linker Histone H1 in Epigenetic Gene Regulation
    Yuhong Fan; Fiscal Year: 2012
    ..expression;3) Study the in vivo regulatory role of H1 in epigenetic gene regulation during embryogenesis and gametogenesis. Findings from these studies will advance our knowledge of epigenetic gene regulation mechanisms...
  27. OOCYTE DEVELOPMENT IN DROSOPHILA
    Lynn Cooley; Fiscal Year: 2013
    ..project will also investigate a fundamental and conserved aspect of gamete development - some or all of animal gametogenesis occurs in syncytial clusters of cells connected by intercellular bridges called ring canals...
  28. Epigenetic Control of a Ras Activator
    Paul D Soloway; Fiscal Year: 2013
    ..provided by applicant): Proper control of epigenetic state is fundamental to human health, beginning with gametogenesis and continuing through fertilization, development and into adulthood...
  29. Chromatin regulatory mechanisms in eukaryotic gametogenesis
    Shelley L Berger; Fiscal Year: 2013
    ..This conservation of the pattern of histone modifications during gametogenesis from yeast to mammals, strongly indicates that epigenetic regulation is fundamental to the normal process of ..
  30. Functions of Piwi proteins and short RNAs in germline
    Alexei A Aravin; Fiscal Year: 2012
    ..the Piwi proteins, are expressed specifically in germ cells with mutant animals showing severe defects in gametogenesis that lead to sterility...
  31. Reproductive Genomics: Mutant Models for Infertility
    Mary Ann Handel; Fiscal Year: 2012
    ..These efforts have generated a unique resource of models for the study of gonadogenesis, gametogenesis, meiosis, and gamete function...
  32. Swallow function and RNA localization in Drosophila oocytes
    NANCY POKRYWKA; Fiscal Year: 2011
    ..of RNA localization in Drosophila, as a means of understanding cytoplasmic organization and its role in gametogenesis. RNAs become localized in oocytes and other cells via interactions with the cytoskeleton, although the precise ..
  33. Transcriptional profiling and annotation of the Chlamydomonas genome
    Sabeeha Merchant; Fiscal Year: 2013
    ..pH, temperature, light intensity, C02 and 02 partial pressures, and under different developmental situations (gametogenesis, zygote, cell wall and flagella regeneration)...
  34. Frontiers in Reproduction Training Course and Symposium
    Mario Ascoli; Fiscal Year: 2013
    ..Section 3 covers gametogenesis and fertilization, and preimplantation and peri-implantation development...
  35. 2011 Mammalian Gametogenesis and Embryogenesis Gordon Research Conference
    Robert E Braun; Fiscal Year: 2011
    ..provided by applicant): This application requests partial funding for the 18th Gordon Conference on Mammalian Gametogenesis and Embryogenesis to be held August 21-26, 2011 at Waterville Valley Resort in Waterville Valley New Hampshire...
  36. Control of cell cycling speed to delay the onset of senescence
    Olivier Cinquin; Fiscal Year: 2013
    ..First, it undergoes continuous cell turnover, with cell proliferation compensating for the loss of cells to gametogenesis;this makes it a suitable model systems for self-renewing organs, such as the intestine, that are an important ..
  37. Transgenic models to investigate imprinted gene expression in somatic tissue
    Matthias Stadtfeld; Fiscal Year: 2013
    ..Mediated by sex-specific chromatin marks established during gametogenesis, the expression status of imprinted alleles is believed to be stable in adult tissues...
  38. The Life of a Stem Cell: From Birth to Death
    JAMES WAVELL AIKEN; Fiscal Year: 2012
    ..Stem cell systems are discussed with respect to the life cycle of whole organisms: gametogenesis and embryogenesis, where tissue types are established;maturity, where organ systems are maintained in ..
  39. Ptbp2 function and global mRNA regulation during mammalian cell development
    DONNY LICATALOSI; Fiscal Year: 2013
    ..To do so, we have developed a new approach to purify male mouse germ cells in each of the major stages of gametogenesis (the process by which sperm are generated)...
  40. HU-IME1 CHARACTERIZATION AND MALE INFERTILITY
    Wael Salameh; Fiscal Year: 1999
    b>Gametogenesis in mammals is characterized by a precise succession of proliferative, meiotic, and cellular differentiation events. Meiosis occurs only in the gonads...
  41. Comparative and functional proteomics of germline chromatin in C. elegans
    KENNETH HILLERS; Fiscal Year: 2009
    ..Our long-term goal is an understanding of the means through which eukaryotes carry out the processes of gametogenesis and meiosis, with a particular emphasis on the behavior of chromosomes during meiosis...
  42. 2004 & 2006 Meiosis Gordon Conference
    DOUGLAS BISHOP; Fiscal Year: 2005
    ..axes; meiotic centromeres and chromosome segregation; progression through the meiotic program during gametogenesis; as well as the evolutionary origins and evolutionary functions of meiosis...
  43. FUNCTION OF SEX SPECIFIC EXONS IN DNMT1 GENE
    Timothy Bestor; Fiscal Year: 2002
    Genomic methylation patterns are established during gametogenesis and early development and propogated in somatic cells by clonal inheritance; disruption of methylation patterns causes fulminating expression of endogenous retroviruses, ..
  44. Structural and Cellular Biology of GPH Receptors
    JAMES ALAN DIAS; Fiscal Year: 2010
    ..FSH is essential for normal high quality gametogenesis in males and females...
  45. REPRODUCTIVE BIOLOGY OF GONADOTROPIN REGULATION
    URSULA KAISER; Fiscal Year: 2000
    Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) regulate gonadal function and gametogenesis, and are critical for normal sexual development and reproductive function...
  46. NOVEL DNA METHYLTRANSFERASES IN DEVELOPMENT AND DISEASE
    Timothy Bestor; Fiscal Year: 2002
    ..occurs in primordial germ cells and preimplantation embryos, while waves of de novo methylation occur during gametogenesis and early postimplantation development...
  47. GERMLINE PROLIFERATION AND MEIOSIS IN C ELEGANS
    Tim Schedl; Fiscal Year: 2000
    ..to either proliferate or enter the meiotic pathway executed? And how are meiotic prophase progression and gametogenesis controlled and coordinated? Disruption of these processes can result in germline tumor formation, sterility ..
  48. Anterior Pituitary Gland in Female Reproductive Aging
    Lisa Halvorson; Fiscal Year: 2002
    Reproductive aging in the female is identified by a progressive decline in ovarian gametogenesis and steroidogenesis...
  49. MECHANISM OF GENOMIC IMPRINTING DURING SPERMATOGENESIS
    Thomas Yang; Fiscal Year: 2000
    ..from investigator's abstract): Genomic imprinting is the process by which certain genes are marked during gametogenesis to differentially express the parental alleles...
  50. 2009 Mammalian Gametogenesis
    Michael Skinner; Fiscal Year: 2009
    ..provided by applicant): This application requests partial funding for the 17th Gordon Conference on Mammalian Gametogenesis and Embryogenesis to be held August 2-7, 2009 at Waterville Valley Resort in Waterville Valley, New Hampshire...
  51. Small RNA Discovery and Analysis in Ascaris
    Richard Davis; Fiscal Year: 2009
    ..zygotic transcription and in early development, and 3) Small RNAs are uniquely associated with the germline, gametogenesis, and organogenesis...
  52. Cell Signaling in Meiosis
    JoAnne Engebrecht; Fiscal Year: 2005
    b>Gametogenesis is essential for the propagation of all sexually reproducing organisms and consists of halving the chromosome number through meiosis, and the subsequent packaging of the haploid products into gametes (sperm and eggs in ..
  53. REPRODUCTIVE BIOLOGY RESEARCH TRAINING FOR LATIN AMERICA
    JEROME STRAUSS; Fiscal Year: 2005
    ..Four research themes are emphasized: molecular endocrinology; gametogenesis and fertilization; early embryo development and implantation; and translational research in contraception and ..
  54. REGULATION OF FOLLICLE-STIMULATING HORMONE BIOSYNTHESIS
    JAMES JAMESON; Fiscal Year: 1990
    Follicle-stimulating hormone (FSH) is important for gametogenesis and gonadal steroid biosynthesis in both males and females. The hormonal regulation of FSH biosynthesis is complex and at present, is poorly understood...
  55. MECHANISMS OF MAMMALIAN MEIOTIC SYNAPSIS
    Terry Ashley; Fiscal Year: 2000
    ..studies will be combined with antibody detection of Rad51, a RecA homologue which appears to play a role in gametogenesis. Aim 2 will attempt to distinguish between two leading models of synaptic initiation...
  56. CELL LINEAGE IN DEVELOPMENT
    ANN GILLIGAN; Fiscal Year: 1992
    ..Genomic imprinting, which occurs during gametogenesis in mammals, imposes different functional states upon maternally and paternally derived genomes...
  57. STRUCTURE OF DNA AND PROTEINS IN MALE GERM CELLS
    DEBRA WOLGEMUTH; Fiscal Year: 1999
    ..and test the hypothesis that these genes function in the development of the male reproductive system and in gametogenesis, using mouse as a model system...
  58. The identification and characterization of the mammalian mutation mei4
    Jeremy Ward; Fiscal Year: 2006
    ..mei4 causes male and female sterility by disrupting gametogenesis during meiosis. Meiosis in mei4/mei4 homozygotes fails to complete due to a lack of recombination...
  59. FRONTIERS IN REPRODUCTION: MOLECULAR & CELLULAR CONCEPTS
    Gerald Schatten; Fiscal Year: 2001
    ..The five modules are integrated to provide broad exposure to emerging problems: Module 1> Gametogenesis and Fertilization; 2. Embryogenesis and Stem Cells; 3. Reproductive Immunology; 4...
  60. Mechanisms of Ovotestis Development
    Brian Ring; Fiscal Year: 2009
    ..The ovotestis is capable of normal gametogenesis and fertilization within a common lumen...
  61. CENTER FOR RESEARCH ON FERTILITY AND INFERTILITY
    Fred Turek; Fiscal Year: 1999
    ..of reproduction, the regulatory mechanisms of gonadal functions, the regulatory mechanisms of gametogenesis, the mechanisms of follicular selection, the mechanisms of action of reproductive hormones, the ..
  62. GENETICS AND BIOCHEMISTRY OF A MURINE RETROPOSON
    Sandra Martin; Fiscal Year: 2009
    ..normal control mechanisms of L1 expression and retrotransposition become deranged either during development (gametogenesis or early embryogenesis) or in somatic cells in response to environmental insults or aging, movement and ..
  63. HEAT-SHOCK-LIKE GENE REGULATION BY REPRODUCTIVE HORMONES
    Charles Mobbs; Fiscal Year: 1993
    ..Heat-shock gene products are induced during gametogenesis in ovaries, testes, and even sporulation, and during early embryonic development; inappropriate expression of ..
  64. ROLES OF MEMBRANE AND SOLUBLE KL IN HEMATOPOIESIS
    Peter Besmer; Fiscal Year: 2002
    ..tyrosine kinase, is encoded at the Sl locus and mice carrying SIS mutations have defects in hematopoiesis, gametogenesis and melanogenesis...
  65. PROTO-ONCOGENES IN GAMETOGENESIS AND EARLY DEVELOPMENT
    GEOFFREY COOPER; Fiscal Year: 1999
    The overall goal of the project is understanding the roles of proto- oncogenes in gametogenesis and early development of mammalian embryos...