fertility

Summary

Summary: The capacity to conceive or to induce conception. It may refer to either the male or female.

Top Publications

  1. pmc Perinatal exposure to environmentally relevant levels of bisphenol A decreases fertility and fecundity in CD-1 mice
    Nicolas J Cabaton
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Environ Health Perspect 119:547-52. 2011
  2. ncbi Epigenetic transgenerational actions of endocrine disruptors and male fertility
    Matthew D Anway
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Science 308:1466-9. 2005
  3. pmc Molecular evolution and functional characterization of Drosophila insulin-like peptides
    Sebastian Gronke
    Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom
    PLoS Genet 6:e1000857. 2010
  4. ncbi A sperm ion channel required for sperm motility and male fertility
    D Ren
    Howard Hughes Medical Institute, Children s Hospital, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 413:603-9. 2001
  5. ncbi Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility
    Cecilia Garlanda
    Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    Annu Rev Immunol 23:337-66. 2005
  6. ncbi American Society of Clinical Oncology recommendations on fertility preservation in cancer patients
    Stephanie J Lee
    Dana Farber Cancer Institute, Boston, MA, USA
    J Clin Oncol 24:2917-31. 2006
  7. pmc Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines
    Jens Peter Bonde
    Department of Occupational Medicine, Aarhus University Hospital, Arhus, Denmark
    Environ Health Perspect 116:269-77. 2008
  8. pmc Dietary composition specifies consumption, obesity, and lifespan in Drosophila melanogaster
    Danielle A Skorupa
    Huffington Center on Aging, and Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Aging Cell 7:478-90. 2008
  9. doi A systematic review of factors influencing fertility desires and intentions among people living with HIV/AIDS: implications for policy and service delivery
    Barbara Nattabi
    Curtin Health Innovation Research Institute, Curtin University of Technology, Perth, WA, 6845, Australia
    AIDS Behav 13:949-68. 2009
  10. pmc Why do people postpone parenthood? Reasons and social policy incentives
    Melinda Mills
    Department of Sociology ICS, University of Groningen, Grote Rozenstraat 31, 9712 TG Groningen, The Netherlands
    Hum Reprod Update 17:848-60. 2011

Detail Information

Publications391 found, 100 shown here

  1. pmc Perinatal exposure to environmentally relevant levels of bisphenol A decreases fertility and fecundity in CD-1 mice
    Nicolas J Cabaton
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Environ Health Perspect 119:547-52. 2011
    ..Perinatal exposure to low-doses of bisphenol A (BPA) results in alterations in the ovary, uterus, and mammary glands and in a sexually dimorphic region of the brain known to be important for estrous cyclicity...
  2. ncbi Epigenetic transgenerational actions of endocrine disruptors and male fertility
    Matthew D Anway
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Science 308:1466-9. 2005
    ..The ability of an environmental factor (for example, endocrine disruptor) to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology...
  3. pmc Molecular evolution and functional characterization of Drosophila insulin-like peptides
    Sebastian Gronke
    Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom
    PLoS Genet 6:e1000857. 2010
    ..Loss of DILP2 increased lifespan and loss of DILP6 reduced growth, while loss of DILP7 did not affect fertility, contrary to its proposed role as a Drosophila relaxin...
  4. ncbi A sperm ion channel required for sperm motility and male fertility
    D Ren
    Howard Hughes Medical Institute, Children s Hospital, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 413:603-9. 2001
    ..CatSper is thus vital to cAMP-mediated Ca2+ influx in sperm, sperm motility and fertilization. CatSper represents an excellent target for non-hormonal contraceptives for both men and women...
  5. ncbi Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility
    Cecilia Garlanda
    Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    Annu Rev Immunol 23:337-66. 2005
    ..In addition, PTX3 is essential in female fertility because it acts as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix...
  6. ncbi American Society of Clinical Oncology recommendations on fertility preservation in cancer patients
    Stephanie J Lee
    Dana Farber Cancer Institute, Boston, MA, USA
    J Clin Oncol 24:2917-31. 2006
    To develop guidance to practicing oncologists about available fertility preservation methods and related issues in people treated for cancer.
  7. pmc Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines
    Jens Peter Bonde
    Department of Occupational Medicine, Aarhus University Hospital, Arhus, Denmark
    Environ Health Perspect 116:269-77. 2008
    ..We synthesized the main findings from an international epidemiologic study on the impact of biopersistent organic pollutants (POPs) on human reproductive function...
  8. pmc Dietary composition specifies consumption, obesity, and lifespan in Drosophila melanogaster
    Danielle A Skorupa
    Huffington Center on Aging, and Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Aging Cell 7:478-90. 2008
    ....
  9. doi A systematic review of factors influencing fertility desires and intentions among people living with HIV/AIDS: implications for policy and service delivery
    Barbara Nattabi
    Curtin Health Innovation Research Institute, Curtin University of Technology, Perth, WA, 6845, Australia
    AIDS Behav 13:949-68. 2009
    ..This paper critically reviews the current literature on fertility desires and reproductive intentions among people living with HIV/AIDS (PLHIV) and critiques the theoretical ..
  10. pmc Why do people postpone parenthood? Reasons and social policy incentives
    Melinda Mills
    Department of Sociology ICS, University of Groningen, Grote Rozenstraat 31, 9712 TG Groningen, The Netherlands
    Hum Reprod Update 17:848-60. 2011
    ....
  11. pmc GnRH signaling, the gonadotrope and endocrine control of fertility
    Stuart P Bliss
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, United States
    Front Neuroendocrinol 31:322-40. 2010
    ..particular, mitogen-activated protein kinase (MAPK) activities regulated by GnRH that are necessary for normal fertility. Recently, new mouse models making use of conditional gene deletion have shed new light on the relationships ..
  12. doi Exploration of relationships between production and fertility traits in dairy cattle via association studies of SNPs within candidate genes derived by expression profiling
    E C G Pimentel
    Animal Breeding and Genetics Group, Department of Animal Sciences, Georg August University, 37075 Gottingen, Germany
    Anim Genet 42:251-62. 2011
    ..of this work was to integrate findings from functional genomics studies with genome-wide association studies for fertility and production traits in dairy cattle...
  13. ncbi Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
    S Dupont
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 163, France
    Development 127:4277-91. 2000
    ..Our results also show that cell proliferation in the prostate and urinary bladder of old ERbetaKO and ERalphabetaKO males is apparently normal...
  14. pmc Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility
    Yuhong Bai
    School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
    Nat Nanotechnol 5:683-9. 2010
    ..water-soluble multiwalled carbon nanotubes into male mice can cause reversible testis damage without affecting fertility. Nanotubes accumulated in the testes, generated oxidative stress and decreased the thickness of the seminiferous ..
  15. doi Reduced glutathione enhances fertility of frozen/thawed C57BL/6 mouse sperm after exposure to methyl-beta-cyclodextrin
    Toru Takeo
    Division of Reproductive Engineering, Center for Animal Resources and Development, Kumamoto University, Kumamoto, Japan
    Biol Reprod 85:1066-72. 2011
    ..mice, the most commonly used genetic background for genetically engineered mice, considerably reduces its fertility. We previously reported that methyl-beta-cyclodextrin dramatically improved the fertility of frozen/thawed C57BL/..
  16. ncbi Prevalence and determinants of fertility intentions of HIV-infected women and men receiving antiretroviral therapy in South Africa
    Landon Myer
    Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, South Africa
    AIDS Patient Care STDS 21:278-85. 2007
    ..therapy (ART) and other health care services for HIV-infected individuals in sub-Saharan Africa, issues of fertility and childbearing have received relatively little attention...
  17. ncbi Capacitation status and in vitro fertility of boar spermatozoa: effects of seminal plasma, cumulus-oocyte-complexes-conditioned medium and hyaluronan
    K Suzuki
    Experimental Farm, Field Science Center FSC, Hokkaido University, Sapporo, Japan
    Int J Androl 25:84-93. 2002
    ..The unclear effects of frozen-thawed CCM and a low dose of HA on penetration rates of boar spermatozoa call for further researches of their function in vivo...
  18. pmc Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility
    Jennifer W Hill
    Center for Diabetes and Endocrine Research, Department of Physiology and Pharmacology, College of Medicine, The University of Toledo, Toledo, OH 43614, USA
    Cell Metab 11:286-97. 2010
    ..female mice display elevated serum testosterone levels and ovarian abnormalities, resulting in reduced fertility. We conclude that direct action of insulin and leptin on POMC neurons is required to maintain normal glucose ..
  19. doi The relationship of family size and composition to fertility desires, contraceptive adoption and method choice in South Asia
    Anuja Jayaraman
    Macro International, Inc, Calverton, MD, USA
    Int Perspect Sex Reprod Health 35:29-38. 2009
    Many countries in South Asia, including Nepal, India and Bangladesh, demonstrate a strong cultural preference for sons, which may influence fertility desires and contraceptive use.
  20. doi Inbreeding promotes female promiscuity
    Łukasz Michalczyk
    School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK
    Science 333:1739-42. 2011
    ..with multiple males) is an evolutionary puzzle, because females can sustain costs from promiscuity, whereas full fertility can be provided by a single male...
  21. pmc The relationship between anogenital distance, fatherhood, and fertility in adult men
    Michael L Eisenberg
    Division of Male Reproductive Medicine and Surgery, Scott Department of Urology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e18973. 2011
    ..Given the correlation between anogenital distance and genital development, we sought to determine if anogenital distance varied in fertile compared to infertile adult men...
  22. doi A deletion in the bone morphogenetic protein 15 gene causes sterility and increased prolificacy in Rasa Aragonesa sheep
    A Martinez-Royo
    CITA, Unidad de Tecnologia en Produccion Animal, 50059 Zaragoza, Spain
    Anim Genet 39:294-7. 2008
    ..As for other mutations in BMP15, this new mutation is associated with increased prolificacy and sterility in heterozygous and homozygous ewes respectively...
  23. ncbi A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
    M Tatar
    Brown University, Providence, RI 02912, USA, University of Massachusetts, Amherst, MA 01003, USA
    Science 292:107-10. 2001
    ....
  24. ncbi Fertility awareness, intentions concerning childbearing, and attitudes towards parenthood among female and male academics
    C Lampic
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, S 751 83 Uppsala, Sweden
    Hum Reprod 21:558-64. 2006
    ..It is relatively unknown to what extent women and men are aware of the age-related decline in female fertility. The aim was to investigate university students' intentions and attitudes to future parenthood and their ..
  25. doi A validated genome-wide association study in 2 dairy cattle breeds for milk production and fertility traits using variable length haplotypes
    J E Pryce
    Biosciences Research Division, Department of Primary Industries Victoria, Bundoora 3083, Australia
    J Dairy Sci 93:3331-45. 2010
    ..association studies (GWAS) were used to discover genomic regions explaining variation in dairy production and fertility traits...
  26. pmc Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene
    D B Lubahn
    Department of Pathology, University of North Carolina, Chapel Hill 27599
    Proc Natl Acad Sci U S A 90:11162-6. 1993
    Estrogen receptor and its ligand, estradiol, have long been thought to be essential for survival, fertility, and female sexual differentiation and development...
  27. ncbi Measuring the effect of fertility decline on the maternal mortality ratio
    Anrudh K Jain
    Population Council, One Dag Hammarskjold Plaza, New York, NY 10017, USA
    Stud Fam Plann 42:247-60. 2011
    ..the maternal mortality ratio (MMR) observed between 1990 and 2008 into two components: decline attributable to fertility decline and decline attributable to safe motherhood programs...
  28. ncbi Long-term proliferation in culture and germline transmission of mouse male germline stem cells
    Mito Kanatsu-Shinohara
    Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Japan
    Biol Reprod 69:612-6. 2003
    ..gonocytes isolated from neonatal mouse testis proliferated over a 5-month period (>10(14)-fold) and restored fertility to congenitally infertile recipient mice following transplantation into seminiferous tubules...
  29. ncbi Sex peptide causes mating costs in female Drosophila melanogaster
    Stuart Wigby
    Department of Biology, University College London, Darwin Building, Gower Street, London, WC1E 6BT, United Kingdom
    Curr Biol 15:316-21. 2005
    ..Hence, rather than benefiting both sexes, receipt of SP decreases female fitness, making SP the first identified gene that is likely to play a central role in sexual conflict...
  30. doi Evidence that meiotic sex chromosome inactivation is essential for male fertility
    Helene Royo
    Department of Stem Cell Research and Developmental Genetics, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Curr Biol 20:2117-23. 2010
    ..Our findings show that MSCI is essential for male meiosis and, as such, provide insight into the differential severity of meiotic mutations' effects on male and female meiosis...
  31. pmc Identification of a nonsense mutation in CWC15 associated with decreased reproductive efficiency in Jersey cattle
    Tad S Sonstegard
    Bovine Functional Genomics, United States Department of Agriculture, Agricultural Research Service, Beltsville, Maryland, USA
    PLoS ONE 8:e54872. 2013
    With the recent advent of genomic tools for cattle, several recessive conditions affecting fertility have been identified and selected against, such as deficiency of uridine monophosphate synthase, complex vertebral malformation, and ..
  32. ncbi Female university students' attitudes to future motherhood and their understanding about fertility
    Tanja Tyden
    Department of Public Health and Caring Sciences, Döbelnsgatan 2, S 752 37, Uppsala, Sweden
    Eur J Contracept Reprod Health Care 11:181-9. 2006
    As highly educated women tend to postpone childbearing, the purpose was to explore female university students' attitudes to future motherhood and their understanding about fertility.
  33. pmc DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa
    Jeffrey B Kerr
    Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3168, Australia
    Mol Cell 48:343-52. 2012
    ..Hence, PUMA and NOXA are critical for DNA damage-induced, TAp63-mediated primordial follicle oocyte apoptosis. Thus, blockade of PUMA may protect fertility during cancer therapy and prevent premature menopause, improving women's health.
  34. pmc A young Drosophila duplicate gene plays essential roles in spermatogenesis by regulating several Y-linked male fertility genes
    Yun Ding
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
    PLoS Genet 6:e1001255. 2010
    ..individualization, coiling, and structural integrity of the sperm axoneme via regulation of several Y chromosome fertility genes post-transcriptionally...
  35. pmc Endocrine regulation of male fertility by the skeleton
    Franck Oury
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Cell 144:796-809. 2011
    ..We now show that, in males, bone acts as a regulator of fertility. Using coculture assays, we demonstrate that osteoblasts are able to induce testosterone production by the ..
  36. doi Women living with HIV in South Africa and their concerns about fertility
    Mzikazi Nduna
    Department of Psychology, University of Witwatersrand, Private Bag X3, Wits, Johannesburg, 2050, South Africa
    AIDS Behav 13:62-5. 2009
    ..Information on women's fertility desires and pregnancy planning was collected through participatory workshop, focus groups, and one-on-one ..
  37. doi Ovary cryopreservation and transplantation for fertility preservation
    S J Silber
    Infertility Center of St Louis, St Luke s Hospital, St Louis, MO 63017, USA
    Mol Hum Reprod 18:59-67. 2012
    ..Grafts of just modest portions of ovarian tissue have lasted >7 years. In vitro studies suggest that vitrification of ovarian tissue may be an improvement over the 70% oocyte viability loss from slow freeze...
  38. pmc The epididymis, cytoplasmic droplets and male fertility
    Trevor G Cooper
    Centre of Reproductive Medicine and Andrology, University of Munster, Munster D 48149, Germany
    Asian J Androl 13:130-8. 2011
    ..sperm swelling at ejaculation, is discussed in relation to loss of cytoplasmic droplets and consequences for fertility. It is postulated that: (i) fertile males possess spermatozoa with sufficient osmolytes to drive RVD at ..
  39. doi Analysis of fertility-related soluble mediators in human uterine fluid identifies VEGF as a key regulator of embryo implantation
    N J Hannan
    Prince Henry s Institute of Medical Research, Monash University, Monash Medical Centre, Clayton, Victoria 3168, Australia
    Endocrinology 152:4948-56. 2011
    ..Identifying the soluble mediators in human uterine fluid and their actions during implantation provides insight into interactions essential for establishing pregnancy, fertility markers, and infertility treatment options.
  40. pmc Extraordinary molecular evolution in the PRDM9 fertility gene
    James H Thomas
    Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e8505. 2009
    ..We suggest instead that PRDM9 is involved in some aspect of centromere segregation conflict and that rapidly evolving centromeric DNA drives changes in PRDM9 DNA-binding domains...
  41. ncbi Severely reduced female fertility in CD9-deficient mice
    F Le Naour
    Institut National de la Sante et de la Recherche Medicale INSERM, Unité 268, Hopital Paul Brousse, 94800 Villejuif, France
    Science 287:319-21. 2000
    ..CD9-/- females displayed a severe reduction of fertility. Oocytes were ovulated but were not successfully fertilized because sperm did not fuse with the oocytes from CD9-..
  42. pmc Three members of the 6-cys protein family of Plasmodium play a role in gamete fertility
    Melissa R van Dijk
    Laboratory for Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS Pathog 6:e1000853. 2010
    ..Mating studies between parasites lacking P230, P48/45 or P47 demonstrate that P230, like P48/45, is a male fertility factor, consistent with the previous demonstration of a protein complex containing both P48/45 and P230...
  43. pmc A deletion in the bovine FANCI gene compromises fertility by causing fetal death and brachyspina
    Carole Charlier
    Unit of Animal Genomics, GIGA R and Faculty of Veterinary Medicine, University of Liège B34, Liege, Belgium
    PLoS ONE 7:e43085. 2012
    b>Fertility is one of the most important traits in dairy cattle, and has been steadily declining over the last decades...
  44. ncbi IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
    Martin Holzenberger
    Institut National de la Santé et de la Recherche Médicale U515, Hopital Saint Antoine, 75571 Paris 12, France
    Nature 421:182-7. 2003
    ..mice do not develop dwarfism, their energy metabolism is normal, and their nutrient uptake, physical activity, fertility and reproduction are unaffected...
  45. doi High pregnancy intentions and missed opportunities for patient-provider communication about fertility in a South African cohort of HIV-positive women on antiretroviral therapy
    Sheree R Schwartz
    WITS Reproductive Health and HIV Institute, Hillbrow Health Precinct, University of the Witwatersrand, Johannesburg, South Africa
    AIDS Behav 16:69-78. 2012
    High fertility intentions amongst HIV-positive women have been reported elsewhere. Less is known about how clinical and HIV treatment characteristics correlate with fertility intentions...
  46. pmc TRY-5 is a sperm-activating protease in Caenorhabditis elegans seminal fluid
    Joseph R Smith
    Department of Human Genetics, University of Utah, Salt Lake City, Utah, USA
    PLoS Genet 7:e1002375. 2011
    ..However, TRY-5 is not required for either hermaphrodite or male fertility, suggesting that hermaphrodite sperm are normally activated by a distinct hermaphrodite-specific activator to ..
  47. pmc Seminal fluid protein allocation and male reproductive success
    Stuart Wigby
    Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Curr Biol 19:751-7. 2009
    ..Our results show that quantitative variation in specific Sfps is likely to play an important role in postcopulatory sexual selection and that investment in Sfp production is essential for male fitness in a competitive environment...
  48. pmc The control of male fertility by spermatozoan ion channels
    Polina V Lishko
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Physiol 74:453-75. 2012
    ..Mutations and deletions in sperm-specific ion channels affect male fertility in both mice and humans without affecting other physiological functions...
  49. pmc Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations
    Kaylon L Bruner-Tran
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Reprod Toxicol 31:344-50. 2011
    ..Herein we demonstrate reduced fertility and an increased incidence of premature birth (PTB) in F1 mice exposed in utero to TCDD as well as in three ..
  50. ncbi Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility
    T R Kumar
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 15:201-4. 1997
    ..Our findings have important implications for male contraceptive development in humans...
  51. pmc Androgen action via testicular peritubular myoid cells is essential for male fertility
    Michelle Welsh
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    FASEB J 23:4218-30. 2009
    Androgens are essential for normal spermatogenesis and male fertility, but how androgens exert this effect remains uncertain...
  52. ncbi FSR1 is essential for virulence and female fertility in Fusarium verticillioides and F. graminearum
    Won Bo Shim
    Department of Plant Pathology and Microbiology, Program for the Biology of Filamentous Fungi, Texas A and M University, College Station 77843 2132, USA
    Mol Plant Microbe Interact 19:725-33. 2006
    ..Our data demonstrate that FSR1 is essential for female fertility and virulence in F. verticillioides. Significantly, targeted disruption of the FSR1 ortholog in F...
  53. ncbi Male fertility in natural populations of red deer is determined by sperm velocity and the proportion of normal spermatozoa
    Aurelio F Malo
    Reproductive Ecology and Biology Group, Museo Nacional de Ciencias Naturales CSIC, 28006 Madrid, Spain
    Biol Reprod 72:822-9. 2005
    ..e., sperm competition). However, the possibility that males also may differ in their fertility has been ignored under the assumption that male infertility is rare in natural populations because selection ..
  54. doi Fertility intentions and reproductive health care needs of people living with HIV in Cape Town, South Africa: implications for integrating reproductive health and HIV care services
    Diane Cooper
    Women s Health Research Unit, School of Public Health and Family Medicine, University of Cape Town, Anzio Road Observatory, 7925, Cape Town, South Africa
    AIDS Behav 13:38-46. 2009
    ..This cross-sectional study investigated the fertility intentions and associated health care needs of 459 women and men, not sampled as intimate partners of each other,..
  55. pmc Wolbachia as a bacteriocyte-associated nutritional mutualist
    Takahiro Hosokawa
    National Institute of Advanced Industrial Science and Technology, Tsukuba 305 8566, Japan
    Proc Natl Acad Sci U S A 107:769-74. 2010
    ....
  56. pmc Antiretroviral therapy is associated with increased fertility desire, but not pregnancy or live birth, among HIV+ women in an early HIV treatment program in rural Uganda
    Marissa Maier
    Department of Internal Medicine, Oregon Health and Science University, Mail Code OP 30, 3181 S W Sam Jackson Park Road, Portland, OR 97239 3098, USA
    AIDS Behav 13:28-37. 2009
    To assess the association between antiretroviral therapy (ART) and fertility history and desire among HIV-positive Ugandan women, we conducted a cross-sectional study among HIV-positive Ugandan women aged 18-50 years who attended an HIV ..
  57. ncbi Fitness advantage and cytoplasmic incompatibility in Wolbachia single- and superinfected Aedes albopictus
    S L Dobson
    Department of Entomology, University of Kentucky, Lexington, KY 40546, USA
    Heredity (Edinb) 93:135-42. 2004
    ..We discuss the observed results in regard to the evolution of the Wolbachia/A. albopictus symbiosis and the observed pattern of Wolbachia infection in natural populations...
  58. pmc The sex peptide of Drosophila melanogaster: female post-mating responses analyzed by using RNA interference
    Tracey Chapman
    Department of Biology, Darwin Building, and Wolfson Institute for Biomedical Research, Cruciform Building, University College London, Gower Street, London WC1E 6BT, UK
    Proc Natl Acad Sci U S A 100:9923-8. 2003
    ..The prolonged "sperm effect" on female receptivity and egg production is therefore entirely attributable to SP, but sperm are necessary for its occurrence...
  59. ncbi Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    Jason G Wood
    Department of Pathology, Harvard Medical School, 77 Ave Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 430:686-9. 2004
    ..Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted. Together these data indicate that STACs slow metazoan ageing by mechanisms that may be related to caloric restriction...
  60. doi Copper/zinc superoxide dismutase insufficiency impairs progesterone secretion and fertility in female mice
    Yoshihiro Noda
    Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, Japan
    Biol Reprod 86:1-8. 2012
    ..To investigate the physiological role of SOD1 in the ovaries, we analyzed the fertility of Sod1-deficient female mice...
  61. ncbi Sexually antagonistic male adaptation triggered by experimental arrest of female evolution
    W R Rice
    Department of Biology, University of California, Santa Cruz 95064, USA
    Nature 381:232-4. 1996
    ..This male adaptation leads to a reduction in female survivorship, which is mediated by an increased rate of remating and increased toxicity of seminal fluid...
  62. doi Quality of life, fertility concerns, and behavioral health outcomes in younger breast cancer survivors: a systematic review
    Jessica Howard-Anderson
    David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 6900, USA
    J Natl Cancer Inst 104:386-405. 2012
    ..review, we examined three key domains of functioning that are particularly relevant for younger breast cancer survivors: health-related quality of life (QOL), menopausal symptoms and fertility concerns, and behavioral health outcomes.
  63. ncbi Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse
    Jingling Jin
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    Biol Reprod 77:37-44. 2007
    ..Catsper1 and Catsper2 that have been shown to play an essential role in sperm hyperactivated motility and male fertility in mice...
  64. pmc RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly
    Jennifer C Y Lo
    Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia
    PLoS Genet 8:e1002969. 2012
    ..Our data demonstrate a novel function for the RABL protein family, an essential role for RABL2 in male fertility and a previously uncharacterised mechanism for protein delivery to the flagellum.
  65. doi Mitonuclear match: optimizing fitness and fertility over generations drives ageing within generations
    Nick Lane
    Department of Genetics, Evolution and Environment, University College London, London, UK
    Bioessays 33:860-9. 2011
    ..Selection for genomic matching is facilitated by two sexes, and optimizes fitness, adaptability and fertility in youth. Mismatches cause infertility, low fitness, hybrid breakdown, and potentially speciation...
  66. pmc Fitness of anopheline mosquitoes expressing transgenes that inhibit Plasmodium development
    Luciano A Moreira
    Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4955, USA
    Genetics 166:1337-41. 2004
    ..By measuring mosquito survival, fecundity, fertility, and by running population cage experiments, we found that mosquitoes transformed with the SM1 construct showed ..
  67. doi Fertility and aging: do reproductive-aged Canadian women know what they need to know?
    Karla L Bretherick
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 1L3, Canada
    Fertil Steril 93:2162-8. 2010
    Female fertility declines with age; however, women are increasingly delaying childbearing until later in their reproductive years...
  68. doi SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice
    Erin L Seifert
    Program for Cancer Therapeutics, Ottawa Hospital Research Institute, Otttawa, Ontario, Canada
    FASEB J 26:555-66. 2012
    ..Thus, the SirT1 protein has functions that can be attributed to the catalytic activity of the protein, as well as other functions that are conferred by the protein itself...
  69. doi Fertility awareness and parenting attitudes among American male and female undergraduate university students
    Brennan D Peterson
    Schmid College of Science, Crean School of Health and Life Sciences, Chapman University, Orange, CA 92866, USA
    Hum Reprod 27:1375-82. 2012
    ..students are more likely to delay childbearing, it is unclear to what extent they are aware of age-related fertility decline...
  70. pmc Fertility and contraceptive decision-making and support for HIV infected individuals: client and provider experiences and perceptions at two HIV clinics in Uganda
    Rhoda K Wanyenze
    Makerere University School of Public Health, Kampala, Uganda
    BMC Public Health 13:98. 2013
    ..This study explored decisions to have or not to have children and contraceptive preferences among PLHIV at two clinics in Uganda...
  71. pmc A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility
    Sabine Schramm
    Department of Cell and Developmental Biology, Biocenter, University of Wurzburg, Wurzburg, Germany
    PLoS Genet 7:e1002088. 2011
    ..By generating a Syce3 knockout mouse, we found that SYCE3 is required for fertility in both sexes. Loss of SYCE3 blocks synapsis initiation and results in meiotic arrest...
  72. pmc ARID4A and ARID4B regulate male fertility, a functional link to the AR and RB pathways
    Ray Chang Wu
    Department of Biochemistry and Molecular Medicine, The George Washington University, Washington, DC 20037, USA
    Proc Natl Acad Sci U S A 110:4616-21. 2013
    ..of Arid4a, combined with haploinsufficiency of Arid4b (Arid4a(-/-)Arid4b(+/-)), showed progressive loss of male fertility, accompanied by hypogonadism and seminal vesicle agenesis/hypodysplasia...
  73. ncbi Plant fertility defects induced by the enhanced expression of microRNA167
    Peng Ru
    National Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institute for Biological Sciences, 300 Fenglin Road, Shanghai 200032, China
    Cell Res 16:457-65. 2006
    ..Our results provide an important link between the miRNA-mediated regulatory pathway of gene expression and the auxin signaling network promoting plant reproductive development...
  74. pmc Cul4A is essential for spermatogenesis and male fertility
    Dragana Kopanja
    Department of Biochemistry and Molecular Genetics M C 669, University of Illinois, College of Medicine, 900 S Ashland Ave, Chicago, IL 60607, USA
    Dev Biol 352:278-87. 2011
    ..The observations identify a novel function of CUL4A in meiotic recombination and demonstrate an essential role of CUL4A in spermatogenesis...
  75. doi Fertility and obstetrical complications in women with LMNA-related familial partial lipodystrophy
    M C Vantyghem
    Service d Endocrinologie Métabolisme Clinique Linquette, Centre Hospitalier Regional et Universitaire de Lille, 6 Rue du Pr Laguesse, Lille, France
    J Clin Endocrinol Metab 93:2223-9. 2008
    ..The aim of our study was to compare the fertility and occurrence of obstetrical complications of women with familial partial lipodystrophy due to LMNA (lamin A/C) ..
  76. pmc Massive changes in genome architecture accompany the transition to self-fertility in the filamentous fungus Neurospora tetrasperma
    Christopher E Ellison
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 3102, USA
    Genetics 189:55-69. 2011
    ..tetrasperma genome and suppression of recombination is necessary for self-fertility. The similarity of the N...
  77. doi Genome-wide association mapping for female fertility traits in Danish and Swedish Holstein cattle
    G Sahana
    Department of Genetics and Biotechnology, Faculty of Agricultural Sciences, Research Centre Foulum, Aarhus University, Tjele, Denmark
    Anim Genet 41:579-88. 2010
    A genome-wide association study was conducted using a mixed model analysis for QTL for fertility traits in Danish and Swedish Holstein cattle...
  78. doi A genome-wide association study using selective DNA pooling identifies candidate markers for fertility in Holstein cattle
    W Huang
    Department of Dairy Science, University of Wisconsin Madison, Madison, WI 53706, USA
    Anim Genet 41:570-8. 2010
    ..This study is the first application of the selective DNA pooling approach using the BovineSNP50 array in cattle...
  79. pmc Artificial triple Wolbachia infection in Aedes albopictus yields a new pattern of unidirectional cytoplasmic incompatibility
    Yuqing Fu
    Department of Entomology, University of Kentucky, Lexington, KY 40546, USA
    Appl Environ Microbiol 76:5887-91. 2010
    ..This unidirectional CI, combined with a high fidelity of maternal inheritance and low fecundity effects, suggests that the artificial cytotype could serve as an appropriate vehicle for gene drive...
  80. pmc Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility
    Kiyoshi Miki
    Laboratories for Reproductive Biology, and Department of Cell and Developmental Biology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 101:16501-6. 2004
    ....
  81. doi Understanding high fertility desires and intentions among a sample of urban women living with HIV in the United States
    Sarah Finocchario-Kessler
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    AIDS Behav 14:1106-14. 2010
    To assess childbearing motivations, fertility desires and intentions, and their relationship with key factors, we conducted a cross-sectional survey among 181 HIV-infected women of reproductive age (15-44 years) receiving clinical care ..
  82. pmc Fertility preservation in women--a practical guide to preservation techniques and therapeutic strategies in breast cancer, Hodgkin's lymphoma and borderline ovarian tumours by the fertility preservation network FertiPROTEKT
    Michael von Wolff
    Department of Gynaecological Endocrinology and Reproductive Medicine, University Women s Hospital, Effingerstrasse 102, 3010 Bern, Switzerland
    Arch Gynecol Obstet 284:427-35. 2011
    b>Fertility preservation methods are playing an increasing role in women up to the age of 40 years because of rising survival rates in those affected by cancer...
  83. ncbi Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
    D J Clancy
    Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Science 292:104-6. 2001
    ..The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved...
  84. doi microRNAs in the testis: building up male fertility
    Marilena D Papaioannou
    Department of Genetic Medicine and Development, University of Geneva Medical School, CH 1211 Geneva 4, Switzerland
    J Androl 31:26-33. 2010
    ..It is anticipated that unraveling miRNA functions in the testis will further our understanding of the regulatory mechanisms of mammalian spermatogenesis...
  85. doi Fertility preservation in adolescents and young adults with cancer
    Jennifer Levine
    Division of Pediatric Oncology, Columbia University Medical Center, New York, NY 10032, USA
    J Clin Oncol 28:4831-41. 2010
    Preservation of fertility is important to adolescent and young adult (AYA) survivors of cancer. Many survivors will maintain their reproductive potential after the successful completion of treatment for cancer...
  86. doi Circadian rhythms and fertility
    David J Kennaway
    Robinson Institute, Research Centre for Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia
    Mol Cell Endocrinol 349:56-61. 2012
    Circadian rhythms impact on a wide range of physiological systems and this impact extends to fertility, such that disruptions to timing systems can impact upon reproductive capacity...
  87. ncbi Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility
    Tim M Wintermantel
    Molecular Biology of the Cell I, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Neuron 52:271-80. 2006
    ..These studies demonstrate that ovulation is driven by estrogen actions upon ERalpha-expressing neuronal afferents to GnRH neurons...
  88. doi Fish germ cells
    Hongyan Xu
    Department of Biological Sciences, National University of Singapore, Singapore 119260, Singapore
    Sci China Life Sci 53:435-46. 2010
    ..The first semi-cloned fish is Holly. Here we review the current status and future directions of understanding and manipulating fish germ cells in basic research and reproductive technology...
  89. ncbi Serum antimullerian hormone levels best reflect the reproductive decline with age in normal women with proven fertility: a longitudinal study
    Ilse A J van Rooij
    Department of Reproductive Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Fertil Steril 83:979-87. 2005
    ..The aim of this study was to assess which of the basal ovarian reserve markers provides the best reflection of the changes occurring in ovarian function over time (i.e., reproductive aging)...
  90. pmc Altered heterochromatin binding by a hybrid sterility protein in Drosophila sibling species
    Joshua J Bayes
    Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98185, USA
    Science 326:1538-41. 2009
    ..These results reveal that rapid heterochromatin evolution affects the onset of hybrid sterility...
  91. ncbi Attitudes toward parenthood and awareness of fertility among postgraduate students in Sweden
    Agneta Skoog Svanberg
    Department of Women s and Children s Health, Uppsala University, Uppsala, Sweden
    Gend Med 3:187-95. 2006
    ..Postponing childbirth is becoming increasingly common in Western countries, especially among women with higher education...
  92. ncbi Changes with age in the level and duration of fertility in the menstrual cycle
    David B Dunson
    Biostatistics Branch, MD A3 03, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, Research Triangle Park, NC 27709, USA
    Hum Reprod 17:1399-403. 2002
    Most analyses of age-related changes in fertility cannot separate effects due to reduced frequency of sexual intercourse from effects directly related to ageing...
  93. pmc The evolutionary costs of immunological maintenance and deployment
    Kurt A McKean
    Department of Biological Sciences, SUNY at Albany, Albany NY 12222, USA
    BMC Evol Biol 8:76. 2008
    ....
  94. pmc Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice
    Ruey Sheng Wang
    Department of Pathology and Urology, George Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Endocr Rev 30:119-32. 2009
    ..Androgen and the AR play important roles in male spermatogenesis and fertility. The recent generation and characterization of male total and conditional AR knockout mice from different ..
  95. pmc Two-stage genome-wide association study identifies integrin beta 5 as having potential role in bull fertility
    Jean M Feugang
    Department of Animal and Dairy Sciences, Mississippi State University, Mississippi State, MS 39762, USA
    BMC Genomics 10:176. 2009
    b>Fertility is one of the most critical factors controlling biological and financial performance of animal production systems and genetic improvement of lines...
  96. ncbi Antral follicle counts are related to age at natural fertility loss and age at menopause
    Frank J Broekmans
    Department of Reproductive Medicine, Division of Obstetrics, Gynecology and Neonatology, University Medical Center Utrecht, 3584 CX, The Netherlands
    Menopause 11:607-14. 2004
    ..This may represent differences in actual reproductive age among women. This hypothesis was tested by cohort comparison for distribution of age at occurrence of reproductive events...
  97. doi Implications of diversity in sperm size and function for sperm competition and fertility
    Montserrat Gomendio
    Reproductive Ecology and Biology Group, Museo Nacional de Ciencias Naturales CSIC, Madrid, Spain
    Int J Dev Biol 52:439-47. 2008
    ..Finally, we show that mean and maximum sperm swimming speed determine male fertility. Other studies have shown that in competitive contexts, males with faster swimming sperm have higher ..
  98. ncbi Two functional but noncomplementing Drosophila tyrosine decarboxylase genes: distinct roles for neural tyramine and octopamine in female fertility
    Shannon H Cole
    Department of Biology, University of Virginia, Charlottesville, Virginia 22903, USA
    J Biol Chem 280:14948-55. 2005
    ..The egg retention phenotype of the dTdc2 mutant and the phenotypes associated with ectopic dTdc expression contribute to a model in which octopamine and tyramine have distinct and separable neural activities...
  99. pmc Persistent high fertility in Uganda: young people recount obstacles and enabling factors to use of contraceptives
    Gorrette Nalwadda
    Department of Nursing, College of Health Sciences Makerere University P, O Box 7072, Kampala, Uganda
    BMC Public Health 10:530. 2010
    High fertility among young people aged 15-24 years is a public health concern in Uganda...
  100. doi Genetics of mammalian meiosis: regulation, dynamics and impact on fertility
    Mary Ann Handel
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Rev Genet 11:124-36. 2010
    ....
  101. ncbi PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans
    I Kawasaki
    Department of Biology, Indiana University, Bloomington 47405, USA
    Cell 94:635-45. 1998
    ..We show that a component of germ granules is essential for fertility in C. elegans and that its primary function is in germline proliferation...

Research Grants75

  1. Physiology of Hypothalamic Neurosteroidal Progesterone
    Paul E Micevych; Fiscal Year: 2013
    ..regulation of the luteinizing hormone (LH) surge and ovulation which are important for both regulating fertility as well as treating infertility. Approximately 12% of women (7...
  2. Functional Analysis of the Dual Specificity Kinase NEK1 in Mammalian Meiosis
    JOANNA KIM HOLLOWAY; Fiscal Year: 2011
    ..Nek1 mutant mice show severe developmental defects, not only in their fertility, but also show growth defects, cranial-facial abnormalities and polycystic kidney disease...
  3. Early Life Conditions, Survival, and Health: A Pedigree-Based Population Study
    Ken R Smith; Fiscal Year: 2013
    ..The project is based on the Utah Population Database (UPDB) and links biomarker data collected from two studies: Fertility, Longevity &Aging study (FLAG) and the Cache County Memory Study (CCMS)...
  4. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..to leptin are infertile, and leptin administration to ob/ob mice, but not weight loss alone, restores their fertility. Studies conducted in obese children deficient in leptin have supported the importance of leptin to fertility...
  5. Novel genomic effects of Y-linked polymorphisms
    Daniel L Hartl; Fiscal Year: 2012
    ..DNA whose only functions are to serve as a pairing partner for the X and to carry genes for maleness or male fertility in different species. Our preliminary findings strongly suggest that this view is false...
  6. Epigenetic effects of developmental endocrine disruptor exposure in the ovary
    Mehmet Uzumcu; Fiscal Year: 2010
    ..applicant): Female reproductive disorders, including precocious puberty, irregular menstrual cycles, and reduced fertility, are increasing among certain human populations...
  7. Analysis of the role of the VRK1 protein kinase in mammalian fertility
    Paula Traktman; Fiscal Year: 2011
    ..homozygous state, both the male and female VRK1-deficient mice are infertile, indicating that the role of VRK in fertility is evolutionarily conserved...
  8. High throughput screen for selective inhibitors of cyclophilin B
    Richard J Bram; Fiscal Year: 2013
    ..is deleterious for tumor cell surviva, we found that mice completely lacking CypB have normal development and fertility with a minor phenotype involving collagen processing, demonstrating that loss of CypB is not required for ..
  9. Transcriptional control of pituitary gonadotropin genes
    Varykina G Thackray; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Project Summary/Abstract Fertility depends on proper neuroendocrine regulation of the hypothalamic-pituitary-gonadal axis...
  10. Regulation of insulins by the Rhox5 homeobox gene supports spermatogenesis
    James Maclean; Fiscal Year: 2009
    ..Untreatable subfertility caused by poor semen quality accounts for 75% of patients consulting for fertility problems Project Narrative Untreatable subfertility caused by poor semen quality accounts for 75% of patients ..
  11. INTERACTION OF THE ESTROGEN RECEPTOR WITH DNA
    ANN NARDULLI; Fiscal Year: 2013
    ..Estrogens and selective estrogen receptor modulators are widely used in regulating fertility, alleviating postmenopausal symptoms, and preventing and treating breast cancer...
  12. Analysis of epigenetic regulation in early mammalian embryos via RNA interference
    Charles R Long; Fiscal Year: 2010
    ..during early embryonic development, concomitant with the period of embryo culture following IVF in fertility clinics...
  13. Vitamin D3 Regulation of the Hypothalamic-Pituitary-Gonadal Axis
    Genevieve S Neal-Perry; Fiscal Year: 2012
    ..D3 regulates the hypothalamic-pituitary-gonadal axis and how vitamin D3 deficiency adversely affects female fertility and reproduction are not understood...
  14. The role of novel, uncultivable bacteria in incident PID
    CATHERINE L contact HAGGERTY; Fiscal Year: 2011
    ..of PID treatment regimens, highlighting the importance of this study to raise awareness for the potential need to revise clinical guidelines in order to preserve fertility and prevent chronic pain in patients at risk.
  15. Mechanistic Characterization and Genetic Analysis of Systemic Iron Homeostasis
    Xin Du; Fiscal Year: 2011
    ..Iron deficiency afflicts 30% of the world's population, and can cause anemia, developmental retardation, fertility problems and immune dysfunction. However, iron is a double-edged sword...
  16. Simultaneous Insulin and Leptin Signaling in POMC Neurons Promotes Fertility and
    LATRICE DOREEN FAULKNER; Fiscal Year: 2013
    ..murine males with these genetic alterations also show increased LH and androgen production and impaired fertility, implying a shared mechanism between the genders...
  17. Cooperative Multicenter Reproductive Medicine Network (U10)
    MARCELLE IVONNE CEDARS; Fiscal Year: 2013
    ..Over the last four decades, women in the developed world have delayed childbirth. Fertility decreases with age, and live birth rates are lower in women over 35 than in younger women...
  18. Validation of Novel Infertility Biomarker
    PETER SUTOVSKY SUTOVSKY; Fiscal Year: 2012
    ..expensive and confined to specialized reference laboratories, as opposed to an inexpensive doctor's office fertility test...
  19. Transposons in Female Reproductive Health and Disease
    Zev Williams; Fiscal Year: 2013
    ..and computational biology with the overarching goal of elucidating the effect of transposons on oocytes and fertility. The training program has been designed to ensure command of RNA and transposon biology as applied to female ..
  20. Functional Analysis of the Dual Specificity Kinase NEK1 in Mammalian Meiosis
    JOANNA KIM HOLLOWAY; Fiscal Year: 2013
    ..Nek1 mutant mice show severe developmental defects, not only in their fertility, but also show growth defects, cranial-facial abnormalities and polycystic kidney disease...
  21. MRNA PROCESSING IN REPRODUCTION AND FERTILIZATION
    Clinton C MacDonald; Fiscal Year: 2013
    ..CSTF2T, that can be a hidden cause of male infertility-hidden, because females missing this gene have normal fertility, while males have severe problems in sperm production...
  22. Experimental engineering of ovarian grafting to promote angiogenesis for fertilit
    GLENN LEWIS SCHATTMAN; Fiscal Year: 2010
    ..or irradiation for cancer and other diseases, more attention is focused on improving their quality-of-life, with fertility one of the top priorities for young people...
  23. Calcium Signaling in the Pubertal Activation of the GnRH Pulse Generator
    Daniel J Spergel; Fiscal Year: 2011
    ..of the pubertal increase in gonadotropin- releasing hormone (GnRH) secretion required for sexual maturation and fertility. The specific aim is to test the hypothesis that pubertal changes in calcium (Ca2+) and calcium-activated ..
  24. STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging - RESUBM
    Sioban D Harlow; Fiscal Year: 2011
    ..The menopausal transition is a period of critical change, including loss of fertility, increased bone resorption, change in lipid profiles and temporal increases in symptoms, sleep disturbances and ..
  25. Molecular Analysis of GnRH Action
    Mark S Roberson; Fiscal Year: 2012
    ..Our understanding of fertility in mammals requires an extensive appreciation of the mechanisms of communication between the brain, pituitary ..
  26. AGE-RELATED ALTERATION OF LEYDIG CELL REDOX ENVIRONMENT A RISK FACTOR FOR SUSCEPT
    Kassim Traore; Fiscal Year: 2013
    ..in life, Leydig cell hyperplasia, testicular atrophy, reduced serum levels of seru testosterone, and reduced fertility. Although the levels of human exposure to DEHP may not themselves result in high enough serum levels to cause ..
  27. Dioxins and Male Pubertal Growth and Development
    Russ B Hauser; Fiscal Year: 2013
    ..to environmental chemicals during the sensitive window of male pubertal development may adversely impact fertility and the next generation through paternally mediated effects...
  28. Laser Spinning Disc Confocal System for live-cell and live-organism microscopy
    Martha C Soto; Fiscal Year: 2012
    ..Drosophila studies of meiosis in the McKim lab have identified molecules required for proper fertility through the development of germ cells, while C...
  29. CONTROL OF GONADOTROPIN SECRETION DURING LACTATION
    Kevin L Grove; Fiscal Year: 2013
    ..amenorrhea, as well as states of energy overabundance, such as obesity, are both associated with disruptions in fertility. These studies focus on states of negative energy balance that are associated with a suppression of reproductive ..
  30. Transcriptional Networks Regulating Luminal Environment in the Epididymis
    Ann Harris; Fiscal Year: 2013
    ..Successful conduct of these studies will provide unique translational opportunities to modify male fertility. In disease states we may be able to reinstate the normal epididymal luminal environment and thereby restore ..
  31. Cell Specific Expression in the Pituitary Gland
    Sally A Camper; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pituitary gland dysfunction affects growth, fertility, the stress response and many other bodily functions...
  32. Regulation and Function of the Rhox8 homeobox gene in granulosa cells
    JAMES ARTHUR MACLEAN; Fiscal Year: 2010
    ..continued production in Rhox5-null animals may explain why they do not exhibit more severe constraints on their fertility. Furthermore, Rhox8 is unique among the Rhox genes in that it remains expressed through the periovulatory window,..
  33. An internet based prospective study of time to pregnancy
    Elizabeth E Hatch; Fiscal Year: 2013
    ..is reported or for up to twelve months, the standard clinical definition of infertility and the time when fertility treatment is typically sought...
  34. Selectivity and Permeation in the Human Voltage-gated Proton Channel, hHv1
    Susan M E Smith; Fiscal Year: 2013
    ..effect on ROS, hHV1 has other functions in basophils, nasal mucosa, sperm, and B cells that implicate it in male fertility, allergic responses, and such diseases as cystic fibrosis, asthma, and lupus...
  35. Paternal Environmental Exposures and Reproductive Outcomes: A Comparison of in Vi
    DEBORAH ANN HANSEN; Fiscal Year: 2013
    ..in vaginal absorption and in exposure of the embryo post conception, and b) deleterious effects that can disrupt fertility through interaction with the neuroendocrine axis...
  36. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard L Stouffer; Fiscal Year: 2013
    ..information on the mechanisms controlling ovulation and the functional lifespan of the corpus luteum, and hence fertility, in primates...
  37. Integration of PR and FoxO Signaling in Pituitary Gonadotropes
    Varykina G Thackray; Fiscal Year: 2010
    ..Metabolic disorders characterized by hyperinsulinemia and insulin resistance are often associated with reduced fertility in women...
  38. Environmental Endocrine Disruptors and Human Sperm Chromosomal Abnormalities
    Melissa Perry; Fiscal Year: 2012
    ..Archived semen, serum, and urine samples are available from 500 men who have attended a large hospital based fertility clinic for fertility evaluation...
  39. The evolutionary and molecular mechanisms underlying sperm performance in an emer
    Heidi S Fisher; Fiscal Year: 2013
    ..traits in Peromyscus makes them a valuable model for studies aimed at understanding the genetic basis of male fertility but, in addition, they also offe an entirely new perspective on gametic interactions...
  40. The Significance of Leptin Signals to Neonatal Somatotropes and Gonadotropes
    Gwen V Childs; Fiscal Year: 2013
    ..studies will also investigate the role of leptin in the postnatal development of lactotropes, timing of puberty, fertility, development of the reproductive organs, and somatotrope or gonadotrope responses to gonadal steroids...
  41. WNT and gonadotropin mediated regulation of ovarian steroidogenesis
    JENNIFER HERNANDEZ GIFFORD; Fiscal Year: 2010
    ..local and circulating estrogen levels influence numerous physiological and pathological processes including fertility and sexual behavior, bone remodeling and the development of various endocrine cancers...
  42. The Role of TAF4b in Spermatogonial Stem Cell Maintenance and Self-Renewal
    Eric Gustafson; Fiscal Year: 2013
    ..factors TFIIA and TFIID execute highly critical and selective functions in regulating reproduction and fertility. This new paradigm of germ cell-specific gene regulation is conserved between invertebrates and vertebrates, and ..
  43. Role of nuclear receptors in origin and differentiation of spermatozoa
    ADAM MICHAEL REITZEL; Fiscal Year: 2011
    ..from the proposed research will characterize novel roles for nuclear receptor function related to human male fertility. The proposed research supports the mission of the Reproductive Sciences Branch of The Eunice Kennedy Shriver ..
  44. Nemo-Like Kinase and the Pathogenesis of Spinal and Bulbar Muscular Atrophy
    TIFFANY WERLYNE TODD; Fiscal Year: 2013
    ..mild androgen insensitivity, presenting with symptoms including gynecomastia, testicular atrophy, and decreased fertility. SBMA is caused by an expansion of a polymorphic CAG trinucleotide repeat in the Androgen Receptor (AR) gene, ..
  45. Catenins: A role in spertmatogenesis and sperm maturation
    MANJEET KUMAR RAO; Fiscal Year: 2010
    ..ES contributes to spermatid sloughing and oligospermia in pathological conditions associated with reduced fertility potential, including varicocele, hyperprolactinemia, diabetes and idiopathic oligospermia...
  46. Lipid metabolism during tsetse reproduction
    JOSH B BENOIT; Fiscal Year: 2013
    ..b>Fertility can be restored in aposymbiotic flies by supplementation of blood meals with yeast extract...
  47. SPATIAL REGULATION OF DEVELOPMENTAL GENE EXPRESSION
    Ronald M Evans; Fiscal Year: 2013
    ..Receptor regulated pathways are particularly relevant in fertility, congenital malformations, prematurity, and respiratory distress syndrome in the United States and this work is ..
  48. Role of Fetal Steroids in Formation and Activation of Bovine Ovarian Follicles
    Joanne E Fortune; Fiscal Year: 2010
    ..as a source of oocytes for ovulation, it is critical for reproductive success and also a potential target for fertility enhancement or contraception...
  49. CONTROL OF MEIOSIS AND GERMLINE PROLIFERATION
    DAVID IRWIN GREENSTEIN; Fiscal Year: 2012
    ..This maternal-age effect represents the major barrier to human fertility and is the chief cause of human birth defects...
  50. Regulation and Function of the Rhox5 Homeobox Gene
    MILES FROME WILKINSON; Fiscal Year: 2013
    ..Because it is testosterone regulated and required for the normal fertility of male mice, studying Rhox5 has the potential to illuminate transcription networks responsible for hormone-..
  51. NEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUS
    Pamela L Mellon; Fiscal Year: 2013
    ..discrete population of ~800 neurons, scattered through the hypothalamus, controls puberty, menstrual cyclicity, fertility, and meno- pause...
  52. CELLULAR AND MOLECULAR BASES FOR RHYTHMIC GNRH RELEASE
    Suzanne M Moenter; Fiscal Year: 2013
    ..Beyond fertility, sex steroids alter development and function of many systems, for example, bone, the central nervous system and ..
  53. Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes
    Russ B Hauser; Fiscal Year: 2013
    ..are very limited clinical and epidemiologic studies on their potential health risks, particularly in relation to fertility and pregnancy loss...
  54. NEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUS
    Pamela L Mellon; Fiscal Year: 2011
    ..It controls puberty, the menstrual cycle, fertility, menopause, and when disregulated, causes infertility...
  55. Genetics of Meiosis and Recombination in Mice
    John C Schimenti; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Faithful transmission of the genome through gametes is critical for fertility, health of offspring, and success of the species...
  56. The XXII nd North American Testis Workshop
    WILLIAM WALLACE WRIGHT; Fiscal Year: 2013
    ..The theme of the XXIInd North American Testis Workshop is, "The Foundations of Male Fertility." The program includes three major lectures: the keynote address, the benchmark lecture, and the European ..
  57. Regulation and Function of Germline RNP Granules
    JENNIFER SCHISA; Fiscal Year: 2010
    ..form in oocytes in order to maintain RNA stability, repress translation, and maintain overall oocyte viability/ fertility. The first specific aim of the proposal is to identify and characterize the genes required for assembly and ..
  58. Embryonic regulation of GnRH neuron migration and function
    David J Kozlowski; Fiscal Year: 2012
    ..to determine the etiology of birth defects and predict clinical outcomes regarding reproductive maturation and fertility. These results in zebrafish complement ongoing clinical research efforts aimed toward identifying the function ..
  59. INVESTIGATIONS OF MAMMALIAN AMINOPROPYLTRANSFERASES
    ANTHONY PEGG; Fiscal Year: 2009
    ..restoring a source of spermine by breeding female Gy carrier mice with CAG-SpmS mice restores normal growth and fertility to these mice despite the unregulated nature of spermine synthase expression...
  60. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    PHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010
    ..Decreased sperm quality, decreased fertility, and decreased sex ratio are reproductive outcomes of substantial public health interest...
  61. Targeting Adenovirus for Gene Therapy of Uterine Leiomyoma
    Ayman Al-Hendy; Fiscal Year: 2013
    ..its potential as a localized treatment for uterine leiomyoma that can control the disease while preserving fertility potential...
  62. Receptor/Ligand Signals for Ovarian Follicular Angiogenesis
    Leon J Spicer; Fiscal Year: 2010
    ..Along with providing advances in our understanding of female fertility and valuable research training experiences for undergraduate students, these studies should lead to new options ..
  63. Multivariate Analysis of the Total Fertility Rate and Its Components
    Robert D Retherford; Fiscal Year: 2010
    This application proposes a new method of multivariate analysis of the total fertility rate (TFR) and its components, applied to individual-level survey or census data...
  64. The Sertoli Cell Product, Doppel, and Male Fertility
    William Wright; Fiscal Year: 2009
    ..Thus, while all data identify Sertoli cells as the most likely source of the Doppel that is required for male fertility, one cannot a priori exclude a role for Doppel produced by the epididymis...
  65. OPTIMIZING SPERMATOGONIAL TRANSPLANTATION FOR FERTILITY PRESERVATION
    Gunapala Shetty; Fiscal Year: 2010
    ..autologous transplantation is the only a potential method for restoring spermatogenesis and possibly rescuing fertility. Although one study indicated that autologous germ cells transplantation might be successful in monkeys, the ..
  66. Full karyotype single cell interphase analysis
    Santiago Munne; Fiscal Year: 2005
    ..typically leads to failed fertilization or spontaneous abortions, resulting in phenotypes called 'reduced fertility'...
  67. A Secular Change in Menstrual Characteristicis of Adult and Midlife Women?
    Sioban D Harlow; Fiscal Year: 2010
    ..in age at menarche or menopause are of scientific interest because their timing is related to women's fertility, risk of chronic diseases, and mortality...
  68. AMP-activated protein kinase management will improve oocyte cryopreservation
    Daniel Allen Rappolee; Fiscal Year: 2010
    Decreased fertility in later reproductive age in women is an increasing trend due to career-building, as ages of first marriage and first birth increase...
  69. Biodemographic Tools for Investigating Postpartum Amenorrhea
    DARRYL HOLMAN; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): In populations that approximate conditions of natural fertility, the period of lactational infecundability is one of the most important and the most variable components of birth intervals, lasting ..
  70. DETERMINANTS OF MALE AND FEMALE FECUNDITY AND FERTILITY-DATA COORDINATING CENTER
    Edward Clark; Fiscal Year: 2009
    ..a prospective pregnancy study was conducted to identify determinants of male and female fecundity and fertility. Previous studies involving experimental animals and wildlife populations report a spectrum of adverse ..
  71. Oxidative stress drives ovarian aging: modification by genetics and environment
    Ulrike Luderer; Fiscal Year: 2009
    b>Fertility declines with age in women, due in large part to decreased ovarian follicle numbers...
  72. CELL-CELL INTERACTIONS IN TESTIS DEVELOPMENT
    Michael Skinner; Fiscal Year: 2007
    ..the cell-cell interactions that regulate testis growth, size, and morphogenesis which directly influence male fertility and sperm production...
  73. CHRONOBIOLOGICAL INVESTIGATION OF TNF AND IL-2
    William Hrushesky; Fiscal Year: 1992
    ..We have also found that the timing of tumor resection within the fertility cycle affects the frequency of subsequent metastatic tumor spread and that the fertility cycle affects the level ..
  74. G PROTEINS AND SIGNAL TRANSDUCTION IN NEUROSPORA CRASSA
    KATHERINE BORKOVICH; Fiscal Year: 2006
    ..GNA-1 is required for apical growth, asexual sporulation and female fertility. GNA-3 is a major regulator of asexual sporulation. GNA-2 function is redundant to GNA-1 and GNA-3...
  75. Explaining Very Low Fertility
    DAVID KERTZER; Fiscal Year: 2007
    ..innovative multidisciplinary methodology and cutting-edge theory to seek a better explanation for very low fertility by focusing on Italy, a country that for the past 15 years has had one of the lowest fertility rates in the ..