Genomes and Genes
Summary: Formation of differentiated cells and complicated tissue organization to provide specialized functions.
Publications301 found, 100 shown here
- Generation and regeneration of cells of the liver and pancreasKenneth S Zaret
Epigenetics and Progenitor Cells Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
Science 322:1490-4. 2008....
- Preparing for the first breath: genetic and cellular mechanisms in lung developmentEdward E Morrisey
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Dev Cell 18:8-23. 2010....
- Cytokinin modulates endocytic trafficking of PIN1 auxin efflux carrier to control plant organogenesisPeter Marhavy
Department of Plant Systems Biology, VIB, Technologiepark 927, B 9052 Gent, Belgium
Dev Cell 21:796-804. 2011..identified an alternative mode of cytokinin action that uses endocytic trafficking as a means to direct plant organogenesis. This activity occurs downstream of known cytokinin receptors but through a branch of the cytokinin signaling ..
- Pancreas organogenesis: from bud to plexus to glandFong Cheng Pan
Dev Dyn 240:530-65. 2011....
- Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid folliclesElina A Kiss
Institute of Medical Microbiology and Hygiene, University of Freiburg Medical Center, Freiburg, Germany
Science 334:1561-5. 2011..Our results establish a molecular link between nutrients and the formation of immune system components required to maintain intestinal homeostasis and resistance to infections...
- Lung organogenesisDavid Warburton
The Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, California, USA
Curr Top Dev Biol 90:73-158. 2010....
- Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital systemThomas J Carroll
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Dev Cell 9:283-92. 2005..Together these findings suggest that Wnt9b is a common organizing signal regulating diverse components of the mammalian urogenital system...
- Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesisS M Knox
Matrix and Morphogenesis Unit, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Drive, Bethesda, MD 20892, USA
Science 329:1645-7. 2010..However, the mechanisms by which epithelial progenitor cells are maintained during organogenesis are poorly understood...
- Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesisXue Li
Howard Hughes Medical Institute, School and Department of Medicine, UCSD, 9500 Gilman Drive, Room 345, La Jolla, California 92093 0648, USA
Nature 426:247-54. 2003..mechanistic relationship between gene activation and repression events is a central question in mammalian organogenesis, as exemplified by the evolutionarily conserved sine oculis (Six), eyes absent (Eya) and dachshund (Dach) ..
- Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesisVictoria V Lunyak
Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, CA 92093 0648, USA
Science 317:248-51. 2007..These data suggest that transcription of interspersed repetitive sequences may represent a developmental strategy for the establishment of functionally distinct domains within the mammalian genome to control gene activation...
- Next-generation regenerative medicine: organogenesis from stem cells in 3D cultureYoshiki Sasai
Neurogenesis and Organogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
Cell Stem Cell 12:520-30. 2013..For some tissues, epithelial-mesenchymal interactions can also be manipulated in coculture to guide organogenesis. This new area of stem cell research-the spatiotemporal control of dynamic cellular interactions-will open a ..
- Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesisVicki Plaks
Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143 0452, USA
Cell Rep 3:70-8. 2013..Loss-of-function and depletion experiments of Lgr5(+) cells from transplanted MECs or from pubertal MGs revealed that these cells are not only sufficient but also necessary for postnatal mammary organogenesis.
- LamininsMadeleine Durbeej
Department of Experimental Medical Science, University of Lund, Sweden
Cell Tissue Res 339:259-68. 2010..Laminins are vital for many physiological functions. They are essential for early embryonic development and organogenesis and have crucial functions in several tissues including muscle, nerve, skin, kidney, lung, and the vasculature...
- Vertebrate endoderm development and organ formationAaron M Zorn
Division of Developmental Biology, Cincinnati Children s Research Foundation and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
Annu Rev Cell Dev Biol 25:221-51. 2009..We review this progress with a focus on early stages of endoderm organogenesis including endoderm formation, gut tube morphogenesis and patterning, and organ specification...
- Origin of stem cells in organogenesisJ M W Slack
Stem Cell Institute, University of Minnesota, McGuire Translational Research Facility, 2001 6th Street SE, Minneapolis, MN 55455, USA
Science 322:1498-501. 2008..Possible explanations for the existence of such cells, and the issue of whether they also exist in vivo, are discussed...
- Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafishJun Chen
Laboratory of Functional Genomics, Laboratory of Molecular and Developmental Immunology, Laboratory of Control of p53 Pathway, Institute of Molecular and Cell Biology, Proteos, Singapore 138673
Genes Dev 19:2900-11. 2005..However, there is currently no direct genetic evidence to show if or how the p53 pathway functions during organogenesis. Here we present evidence to show that the zebrafish def (digestive-organ expansion factor) gene encodes a ..
- T-box genes in vertebrate developmentL A Naiche
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Annu Rev Genet 39:219-39. 2005..regulation of the development of extraembryonic structures, embryonic patterning, and many aspects of organogenesis. They are unusual in displaying dosage sensitivity in most instances...
- Primary cilia and organogenesis: is Hedgehog the only sculptor?Evangelia Tasouri
Interdisciplinary Center for Neurosciences, Institute of Anatomy and Cell Biology, University of Heidelberg, Im Neuenheimer Feld 307, Heidelberg, Germany
Cell Tissue Res 345:21-40. 2011..critical dependency of signal transduction of the Hedgehog pathway upon functionally intact cilia to regulate organogenesis. Another common theme is the role that the cilium plays, not necessarily in the determination of the embryonic ..
- Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesisHenrique Veiga-Fernandes
Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Nature 446:547-51. 2007Normal organogenesis requires co-ordinate development and interaction of multiple cell types, and is seemingly governed by tissue specific factors...
- Follistatin operates downstream of Wnt4 in mammalian ovary organogenesisHumphrey H C Yao
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
Dev Dyn 230:210-5. 2004..Thus, we propose that WNT4 acts through FST to regulate vascular boundaries and maintain germ cell survival in the ovary...
- Stabilization of beta-catenin impacts pancreas growthPatrick W Heiser
Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
Development 133:2023-32. 2006..Robust stabilization of beta-catenin during early organogenesis drives changes in hedgehog and Fgf10 signaling and induces a loss of Pdx1 expression in early pancreatic ..
- MicroRNA networks in mouse lung organogenesisJie Dong
Division of General Thoracic Surgery, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, USA
PLoS ONE 5:e10854. 2010..MiRNA networks and their regulation of messenger RNA (mRNA) translation and protein expression in specific biological processes are poorly understood...
- Biliary tree stem cells, precursors to pancreatic committed progenitors: evidence for possible life-long pancreatic organogenesisYunfang Wang
Department of Cell Biology and Physiology, Program in Molecular Biology and Biotechnology, Lineberger Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
Stem Cells 31:1966-79. 2013..The biliary tree-derived stem cells and their connections to pancreatic committed progenitors constitute a biological framework for life-long pancreatic organogenesis.
- Retinoic acid synthesis and signaling during early organogenesisGregg Duester
Burnham Institute for Medical Research, Development and Aging Program, La Jolla, CA 92037, USA
Cell 134:921-31. 2008Retinoic acid, a derivative of vitamin A, is an essential component of cell-cell signaling during vertebrate organogenesis. In early development, retinoic acid organizes the trunk by providing an instructive signal for posterior ..
- Canopy1, a positive feedback regulator of FGF signaling, controls progenitor cell clustering during Kupffer's vesicle organogenesisTakaaki Matsui
Gene Regulation Research, Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Nara 630 0101, Japan
Proc Natl Acad Sci U S A 108:9881-6. 2011..Our results therefore uncover both a previously unidentified role of FGF signaling during vertebrate organogenesis and a regulatory mechanism underlying cell cluster formation, which is an indispensable step for formation of ..
- The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesisMarc Sylva
Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
PLoS ONE 6:e22616. 2011..Taken together, these observations show that Fstl1 is a crucial regulator in BMP signalling during mouse development...
- Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- miceRolf Grabner
Institute for Vascular Medicine, Friedrich Schiller University of Jena, 07743 Jena, Germany
J Exp Med 206:233-48. 2009..Thus, the LTbetaR pathway has a major role in shaping the immunological characteristics and overall integrity of the arterial wall...
- Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidneyMichelle Self
Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
EMBO J 25:5214-28. 2006..We propose that in the developing kidney, Six2 activity is required for maintaining the mesenchymal progenitor population in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud...
- Fgf10 regulates hepatopancreatic ductal system patterning and differentiationP Duc Si Dong
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and the Diabetes Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94158, USA
Nat Genet 39:397-402. 2007During organogenesis, the foregut endoderm gives rise to the many different cell types that comprise the hepatopancreatic system, including hepatic, pancreatic and gallbladder cells, as well as the epithelial cells of the ..
- Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephronHui Teng Cheng
Department of Molecular Biology and Pharmacology at Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, St Louis, MO 63110, USA
Development 134:801-11. 2007..These results establish distinct (non-redundant), instructive roles for Notch receptors in nephron segmentation...
- Mechanisms of ectodermal organogenesisJohanna Pispa
Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
Dev Biol 262:195-205. 2003..The molecular signals regulating organogenesis, such as molecules in the FGF, TGFbeta, Wnt, and hedgehog families, regulate the development of all ectodermal ..
- Opposing Wnt pathways orient cell polarity during organogenesisJennifer L Green
Howard Hughes Medical Institute Division of Biology, California Institute of Technology, Mail Code 156 29, Pasadena, CA 91125, USA
Cell 134:646-56. 2008..Thus, tissue polarity is determined by the integration of multiple Wnt pathways...
- Vertebrate limb bud development: moving towards integrative analysis of organogenesisRolf Zeller
Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
Nat Rev Genet 10:845-58. 2009The limb bud is of paradigmatic value to understanding vertebrate organogenesis. Recent genetic analysis in mice has revealed the existence of a largely self-regulatory limb bud signalling system that involves many of the pathways that ..
- The FoxA factors in organogenesis and differentiationKlaus H Kaestner
Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6145, United States
Curr Opin Genet Dev 20:527-32. 2010The genetic analysis of the Foxa genes in both total and conditional mutant mice has clearly established that organogenesis of multiple systems is controlled by this subfamily of winged helix transcription factors...
- Coordinated control of cell adhesion, polarity, and cytoskeleton underlies Hox-induced organogenesis in DrosophilaBridget Lovegrove
Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom
Curr Biol 16:2206-16. 2006..Much research has been devoted to the search for these targets and the characterization of their roles in organogenesis. This has shown that the direct targets of Hox activation are often transcription factors or signaling ..
- Histone deacetylase 3 (hdac3) is specifically required for liver development in zebrafishMuhammad Farooq
Department of Biological Sciences, National University of Singapore, 117543, Singapore
Dev Biol 317:336-53. 2008..These results revealed a novel and specific role of hdac3 in liver development and the distinct functions between hdac1 and hdac3 in zebrafish embryonic development...
- Comparative transcriptome analysis reveals vertebrate phylotypic period during organogenesisNaoki Irie
Laboratory for Evolutionary Morphology, RIKEN Center for Developmental Biology, Chuo Ku, Kobe, Hyogo 650 0047, Japan
Nat Commun 2:248. 2011..followed by diversifying later stages, and the 'hourglass' model, in which constraints are imposed to conserve organogenesis stages, which is called the phylotypic period...
- The Fox genes in the liver: from organogenesis to functional integrationJohn Le Lay
Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
Physiol Rev 90:1-22. 2010..We discuss the biochemical and genetic roles of Foxa, Foxl1, Foxm1, and Foxo, as these have been shown to regulate many processes throughout the life of the organ, controlling both formation and function of the liver...
- Feather regeneration as a model for organogenesisSung Jan Lin
Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Children s Hospital and National Taiwan University Hospital, No 8 Chung Shan South Road, Taipei, Taiwan
Dev Growth Differ 55:139-48. 2013In the process of organogenesis, different cell types form organized tissues and tissues are integrated into an organ...
- Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesisSabine Jurado
St Vincent s Institute of Medical Research, Fitzroy, Australia
PLoS Genet 6:e1001170. 2010..Altogether, the data indicate that, in addition to its role in the DNA base damage response, ASCIZ has separate developmental functions as an essential regulator of respiratory organogenesis.
- Def functions as a cell autonomous factor in organogenesis of digestive organs in zebrafishTing Tao
Key Laboratory for Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang Province, China
PLoS ONE 8:e58858. 2013..However, the molecular mechanism for the involvement of Def in the organogenesis of digestive organs is still largely unknown...
- p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiationJohanna Laurikkala
Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
Development 133:1553-63. 2006..We also demonstrate that BMP2, BMP7 and FGF10 are potent inducers of p63 in cultured tissue explants. Hence, we suggest that p63 regulates the morphogenesis of surface ectoderm and its derivatives via multiple signalling pathways...
- A comparative study of prenatal development in Miniopterus schreibersii fuliginosus, Hipposideros armiger and H. prattiZhe Wang
School of Life Sciences, East China Normal University, Shanghai 200062, PR China
BMC Dev Biol 10:10. 2010..Bats comprise the second largest order of mammals. However, there are far fewer morphological studies of post-implantation embryonic development than early embryonic development in bats...
- Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathwaysBryan Lo
Genentech, South San Francisco, CA 94080, USA
J Cell Biol 199:1117-30. 2012..Combining culture of embryonic tissues with genetic manipulation and chemical genetics thus provides a powerful approach to unraveling developmental programs and understanding cancer initiation...
- PRC2 during vertebrate organogenesis: a complex in transitionIssam Aldiri
Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Dev Biol 367:91-9. 2012During organogenesis, tissues expand in size and eventually acquire consistent ratios of cells with dazzling diversity in morphology and function...
- Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafishXuBo Niu
Key Laboratory for Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou, PR China
Dev Biol 367:197-207. 2012..Although it has been studied in depth in yeast and cultured cells, the role of COPII in organogenesis in a multicellular organism has not...
- Osteoclasts in bone modeling, as revealed by in vivo imaging, are essential for organogenesis in fishMasahiro Chatani
Department of Biological Information, Tokyo Institute of Technology, Midori ku, Yokohama, Japan
Dev Biol 360:96-109. 2011..Here we showed the important role of osteoclasts in organogenesis by establishing osteoclast-specific transgenic medaka lines and by using a zebrafish osteoclast-deficient line...
- Sfrp5 modulates both Wnt and BMP signaling and regulates gastrointestinal organogenesis [corrected] in the zebrafish, Danio rerioCarsten Stuckenholz
Department of Medicine, Division of Hematology Oncology, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 8:e62470. 2013..We show that Sfrp5 inhibits both canonical and non-canonical Wnt signaling during embryonic and endodermal development, resulting in endodermal abnormalities...
- Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathwaySimon D Bamforth
Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Nat Genet 36:1189-96. 2004..We propose that an abnormal Nodal-Pitx2c pathway represents a unifying mechanism for the cardiovascular malformations observed in Cited2(-/-) mice, and that such malformations may be the sole manifestation of a laterality defect...
- Roles of PDGF in animal developmentRenée V Hoch
Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Development 130:4769-84. 2003..elegans, Drosophila, Xenopus, zebrafish and mouse. Early data from these different systems suggest that some functions of PDGFs have been evolutionarily conserved...
- Organogenesis and tumorigenesis: insight from the JAK/STAT pathway in the Drosophila eyeYing Hsuan Wang
Department of Life Science and Institute of Molecular Biology, National Chung Cheng University, Chia Yi, Taiwan
Dev Dyn 239:2522-33. 2010..In this review, we focus on the functions and regulation of the JAK/STAT pathway during eye development and provide some insights into the study of this pathway in tumorigenesis...
- Stem cell activation by light guides plant organogenesisSaiko Yoshida
Institute of Plant Sciences, University of Bern, CH 3013 Bern, Switzerland
Genes Dev 25:1439-50. 2011..In contrast to common wisdom over the last 150 years, the light environment controls the initiation of lateral organs by regulating two key hormones: auxin and cytokinin...
- Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitorsPallavi Bhattaram
Department of Cell Biology, and Orthopaedic and Rheumatologic Research Center, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio 44195, USA
Nat Commun 1:9. 2010During organogenesis, neural and mesenchymal progenitor cells give rise to many cell lineages, but their molecular requirements for self-renewal and lineage decisions are incompletely understood...
- The chemokine receptor CXCR7 functions to regulate cardiac valve remodelingSangho Yu
Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
Dev Dyn 240:384-93. 2011..Thus, CXCR7 is involved in semilunar valve development, possibly by regulating BMP signaling, and may contribute to aortic and pulmonary valve stenosis...
- Organogenesis of peripheral lymphoid organsShin ichi Nishikawa
RIKEN Center for Developmental Biology, Chou ku, Kobe, Japan
Immunol Rev 195:72-80. 2003..that lymphotoxin alpha (LTalpha) knockout mice lack peripheral lymphoid tissues reformed the study of organogenesis of peripheral lymphoid tissues from a research field that was solely descriptive and dependent on histological ..
- A Sall4 mutant mouse model useful for studying the role of Sall4 in early embryonic development and organogenesisMadhuri Warren
Genesis 45:51-8. 2007....
- Repulsion by Slit and Roundabout prevents Shotgun/E-cadherin-mediated cell adhesion during Drosophila heart tube lumen formationEDGARDO SANTIAGO-MARTINEZ
Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
J Cell Biol 182:241-8. 2008..Our data show that Slit and Robo pathways function in lumen formation as a repulsive signal to antagonize E-Cad-mediated cell adhesion...
- Molecular principles of hair follicle induction and morphogenesisRuth Schmidt-Ullrich
Department of Cell Growth and Differentiation, Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
Bioessays 27:247-61. 2005..interactions, and can be divided into morphologically distinguishable stages (induction, organogenesis and cytodifferentiation)...
- Transcriptome analysis of early organogenesis in human embryosHai Fang
Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine SJTU SM, Shanghai 200025, China
Dev Cell 19:174-84. 2010..Here, we report transcriptome profiles of human early embryos covering development during the first third of organogenesis. We identified two major categories of genes, displaying gradually reduced or gradually increased expression ..
- Kidney development: two tales of tubulogenesisMelissa Little
Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia
Curr Top Dev Biol 90:193-229. 2010..individual players and codependent interrelationships between a branched and non-branched tubular network make organogenesis in the kidney unique. Here we review both what is known and remains to be understood in kidney tubulogenesis.
- Four-dimensional realistic modeling of pancreatic organogenesisYaki Setty
Computational Biology Group, Microsoft Research, Cambridge CB3 0FB, United Kingdom
Proc Natl Acad Sci U S A 105:20374-9. 2008b>Organogenesis, the process by which organs develop from individual precursor stem cells, requires that the precursor cells proliferate, differentiate, and aggregate to form a functioning structure...
- Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genesS W Davis
University of Michigan Medical School, Ann Arbor, MI 41809 5618, USA
Mol Cell Endocrinol 323:4-19. 2010Defects in pituitary gland organogenesis are sometimes associated with congenital anomalies that affect head development. Lesions in transcription factors and signaling pathways explain some of these developmental syndromes...
- FACS-assisted microarray profiling implicates novel genes and pathways in zebrafish gastrointestinal tract developmentCarsten Stuckenholz
Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Gastroenterology 137:1321-32. 2009..To identify differentially regulated genes important in gastrointestinal organogenesis, we profiled the transcriptome of the zebrafish developing gastrointestinal tract.
- Restriction of hepatic competence by Fgf signalingDonghun Shin
Department of Biochemistry and Biophysics, Liver Center, Institute for Regeneration Medicine, University of California, San Francisco, CA 94158, USA
Development 138:1339-48. 2011..These data provide in vivo evidence that endodermal cells outside the liver-forming region retain hepatic competence and show that an extrinsic signal, Fgf10a, negatively regulates hepatic competence...
- Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathwaysRathi D Thiagarajan
Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia
PLoS ONE 6:e17286. 2011..a further 92 compartment-enriched genes able to subcompartmentalise key processes during murine renal organogenesis spatially or ontologically...
- Serotonin transporter function is an early step in left-right patterning in chick and frog embryosTakahiro Fukumoto
Cytokine Biology Department, The Forsyth Institute, Harvard Medical School, Boston, Mass 02115, USA
Dev Neurosci 27:349-63. 2005..Taken together our data characterize two new right-sided markers in chick gastrulation, identify a novel, early component of the left-right pathway in two vertebrate species, and reveal a new biological role for serotonin transport...
- An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cellsGerard Eberl
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
Nat Immunol 5:64-73. 2004..This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues...
- MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell linesNadine Baroukh
INSERM, U145, Nice, F 06107, France
J Biol Chem 282:19575-88. 2007....
- Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporterFiona Rae
Institute for Molecular Bioscience and ARC Special Research Centre for Functional and Applied Genomics, University of Queensland, Brisbane, Queensland 4072, Australia
Dev Biol 308:232-46. 2007All solid organs contain resident monocyte-derived cells that appear early in organogenesis and persist throughout life. These cells are critical for normal development in some organs...
- Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardiumYi Hui Chen
Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center and Hospital, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9176, USA
BMC Dev Biol 8:75. 2008..Msx1 and Msx2 have well-documented roles in mediating epithelial-mesenchymal interactions during organogenesis. Given that both Msx1 and Msx2 are crucial downstream effectors of Bmp signaling, we investigated whether Msx1 ..
- An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cellsAmelie Calmont
Cell and Developmental Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA
Dev Cell 11:339-48. 2006..The finding of separate pathways for endoderm tissue specification and growth provides insights for guiding cellular regeneration and stem cell differentiation...
- Molecular genetic cascades for external genitalia formation: an emerging organogenesis programG Yamada
Center for Animal Resources and Development CARD, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
Dev Dyn 235:1738-52. 2006..Development of the male and female external genitalia is also reviewed...
- Kidney development and disease in the zebrafishIain A Drummond
Department of Medicine, Harvard Medical School and Renal Unit, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
J Am Soc Nephrol 16:299-304. 2005..This short review outlines recent progress in applying the zebrafish pronephros to issues of human health and development...
- Functional microarray analysis of mammary organogenesis reveals a developmental role in adaptive thermogenesisStephen R Master
Department of Cancer Biology and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
Mol Endocrinol 16:1185-203. 2002The use of DNA microarrays to study vertebrate organogenesis presents unique analytical challenges compared with expression profiling of homogeneous cell populations...
- GATA4 and GATA6 control mouse pancreas organogenesisManuel Carrasco
Centro Andaluz de Biologia Molecular y Medicina Regenerativa CABIMER, Sevilla, Spain
J Clin Invest 122:3504-15. 2012Recently, heterozygous mutations in GATA6 have been found in neonatal diabetic patients with failed pancreatic organogenesis. To investigate the roles of GATA4 and GATA6 in mouse pancreas organogenesis, we conditionally inactivated these ..
- Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restorationFong Cheng Pan
Vanderbilt University Program in Developmental Biology, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Development 140:751-64. 2013Pancreatic multipotent progenitor cells (MPCs) produce acinar, endocrine and duct cells during organogenesis, but their existence and location in the mature organ remain contentious...
- Organogenesis for kidney regenerationShinya Yokote
Project Laboratory for Kidney Regeneration, Department of Internal Medicine, Institute of DNA Medicine, The Jikei University School of Medicine, Tokyo, Japan
Curr Opin Organ Transplant 18:186-90. 2013....
- Direct control of the proneural gene atonal by retinal determination factors during Drosophila eye developmentMiho Tanaka-Matakatsu
Ben May Department for Cancer Research, The University of Chicago, 929 E 57th Street, Chicago, IL 60637, USA
Dev Biol 313:787-801. 2008..These results demonstrate a direct mechanism by which the RD factors regulate ato expression and suggest an important role of Dpp in the activation of ato 3' enhancer is to regulate the levels of RD factors...
- Organogenesis of the vertebrate heartLucile Miquerol
Aix Marseille Universite, Developmental Biology Institute of Marseille Luminy, France
Wiley Interdiscip Rev Dev Biol 2:17-29. 2013b>Organogenesis of the vertebrate heart involves a complex sequence of events initiating with specification and differentiation of myocardial and endocardial cells in anterior lateral mesoderm shortly after gastrulation, followed by ..
- Thymus organogenesis and development of the thymic stromaCraig S Nowell
Institute for Stem Cell Research, University of Edinburgh, UK
Methods Mol Biol 380:125-62. 2007..Here, we describe the structural and phenotypic attributes of the thymic stroma, and review current cellular and molecular understanding of thymus organogenesis.
- Transcriptional control of mammalian pancreas organogenesisDavid A Cano
Endocrinology Unit, Instituto de Biomedicina de Sevilla IBiS, Hospital Universitario Virgen del Rocío Consejo Superior de Investigaciones Científicas Universidad de Sevilla, Seville, Spain
Cell Mol Life Sci 71:2383-402. 2014..the last decade, significantly advancing our understanding of the molecular mechanisms that control pancreas organogenesis. This growth has been fueled, in part, by the need to generate new therapeutic approaches for the treatment of ..
- Transcriptional regulation of thymus organogenesis and thymic epithelial cell differentiationNancy R Manley
Department of Genetics, University of Georgia Athens, Georgia, USA
Prog Mol Biol Transl Sci 92:103-20. 2010..thymus, several key transcription factors have been identified that are critical for various aspects of thymus organogenesis and thymic epithelial cell (TEC) differentiation...
- Making or breaking the heart: from lineage determination to morphogenesisDeepak Srivastava
Gladstone Institute of Cardiovascular Disease and Department of Pediatrics and Biochemistry, University of California, San Francisco, CA 94158, USA
Cell 126:1037-48. 2006....
- Normal and disease-related biological functions of Twist1 and underlying molecular mechanismsQian Qin
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Cell Res 22:90-106. 2012..Further understanding of the mechanisms by which Twist1 promotes metastasis and identification of Twist1 functional modulators may hold promise for developing new strategies to inhibit EMT and cancer metastasis...
- Ectopic gene expression and organogenesis in Arabidopsis mutants missing BRU1 required for genome maintenanceYusuke Ohno
Bioscience and Biotechnology Center, Nagoya University, Chikusa, Nagoya 464 8601, Japan
Genetics 189:83-95. 2011..bru1 mutants exhibited adventitious organogenesis, probably due to the misexpression of such developmental regulators...
- Organogenesis in a dish: modeling development and disease using organoid technologiesMadeline A Lancaster
IMBA Institute of Molecular Biotechnology of the Austrian Academy of Science Vienna 1030, Austria
Science 345:1247125. 2014..Furthermore, they have potential for drug testing and even future organ replacement strategies. Here, we summarize this rapidly evolving field and outline the potential of organoid technology for future biomedical research. ..
- WNT/beta-catenin signaling in nephron progenitors and their epithelial progenyKai M Schmidt-Ott
Max Delbruck Center for Molecular Medicine, Berlin, Germany
Kidney Int 74:1004-8. 2008..We review current evidence on the WNT/beta-catenin/TCF/Lef1 signaling pathway in kidney epithelial development and discuss the potential implication of non-canonical WNT signaling and WNT-independent events...
- Mechanisms of thymus organogenesis and morphogenesisJulie Gordon
Department of Genetics, University of Georgia, Athens, Georgia 30602, USA
Development 138:3865-78. 2011..T cell differentiation within the thymus has been an area of intense investigation, the study of thymus organogenesis has made slower progress...
- Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cellsYoungjo Kim
Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, USA
Science 334:1706-10. 2011..However, B-type lamins are required for proper organogenesis. Defects in spindle orientation in neural progenitor cells and migration of neurons probably cause brain ..
- Pre-procambial cells are niches for pluripotent and totipotent stem-like cells for organogenesis and somatic embryogenesis in the peach palm: a histological studyMarcílio de Almeida
Departamento de Ciências Biológicas PPG em Fisiologia e Bioquímica de Plantas e PPG em Recursos Florestais, Escola Superior de Agricultura Luiz de Queiroz, Universidade de Sao Paulo, Piracicaba, São Paulo 13 418 900, Brazil
Plant Cell Rep 31:1495-515. 2012..PPCs provide niches for multipotent, pluripotent and totipotent stem-like cells for vascular differentiation, organogenesis and somatic embryogenesis in the peach palm...
- Genetic control of morphogenesis - Hox induced organogenesis of the posterior spiraclesJames Castelli Gair Hombría
CABD, CSIC Universidad Pablo de Olavide, Sevilla, Spain
Int J Dev Biol 53:1349-58. 2009..We believe this may be a common characteristic for Hox induced organogenesis.
- Gata6 is an important regulator of mouse pancreas developmentKimberly Decker
Program in Molecular Biology, Department of Biochemistry and Molecular Genetics, University of Colorado at Denver Health Sciences Center, Aurora, CO 80045, USA
Dev Biol 298:415-29. 2006..Conversely, the majority of transgenic Gata4-Engrailed embryos do not have a pancreatic phenotype. This study suggests that Gata6 is an important regulator of pancreas specification...
- Genetic control of cell morphogenesis during Drosophila melanogaster cardiac tube formationCaroline Medioni
Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique UMR 6216, Universite de la Mediterranee, 13288 Marseille, Cedex 9, France
J Cell Biol 182:249-61. 2008..We suggest that this new example of tube formation may be helpful in studying vertebrate heart tube formation and primary vasculogenesis...
- Laminin α5 guides tissue patterning and organogenesisCaroline Spenlé
INSERM U682, Universite de Strasbourg, Strasbourg, France
Cell Adh Migr 7:90-100. 2013..They participate in the modulation of epithelial/mesenchymal interactions and are implicated in organogenesis and maintenance of organ homeostasis...
- Growth patterns of human ovarian volume during intrauterine and postnatal organogenesisChiarella Sforza
Functional Anatomy Research Center FARC, Dipartimento di Morfologia Umana, Facoltà di Medicina e Chirurgia and Facoltà di Scienze Motorie, Universita degli Studi di Milano, Via Mangiagalli 31, I 20133 Milan, Italy
Early Hum Dev 80:7-17. 2004..In contrast, conclusive studies on normal human ovarian volume during intrauterine and postnatal organogenesis, when the folliculogenesis occurs, do not exist.
- Shotgun proteomic analysis on the embryos of silkworm Bombyx mori at the end of organogenesisJian Ying Li
College of Animal Sciences, Zhejiang University, Hangzhou 310029, PR China
Insect Biochem Mol Biol 40:293-302. 2010..mori embryos at the end of organogenesis (tubercle appearance stage, TA) was characterized using LTQ-Orbitrap mass spectrometer...
- Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stromaYasuhiro Mouri
Division of Molecular Immunology, Institute for Enzyme Research, The University of Tokushima, Tokushima 770 8503, Japan
J Immunol 186:5047-57. 2011..LTβR and RANK signals for optimal mTEC differentiation was underscored by the exaggerated defect of thymic organogenesis observed in mice doubly deficient for these signals...
- p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and PrkdcRebecca A Gladdy
Program in Developmental Biology, Hospital for Sick Children Research Institute, Toronto Medical Discovery Tower Building East Tower, Room 14 312, 101 College Street, Toronto, Ontario, Canada M5G 1L7
Mol Cancer Res 4:311-8. 2006..Here, we show that ATM and Prkdc collaborate to maintain genomic stability during gastrulation and early organogenesis, a period of rapid proliferation and hypersensitivity to DNA damage. At E7.5 to E8...
- Neuron navigator 3a regulates liver organogenesis during zebrafish embryogenesisChristian Klein
Department of Angiogenesis and Cardiovascular Pathology, Max Delbrueck Center for Molecular Medicine MDC, Berlin, Germany
Development 138:1935-45. 2011Endodermal organogenesis requires a precise orchestration of cell fate specification and cell movements, collectively coordinating organ size and shape...
- Fate maps of ventral and dorsal pancreatic progenitor cells in early somite stage mouse embryosRika Miki
Department of Stem Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
Mech Dev 128:597-609. 2012..Dorsal pancreatic progenitors originate from the dorsal endoderm at the 3-6 somite level at 7-9 ss, though they have not yet diverged from the dorsal gut progenitors at this stage...
- De novo shoot organogenesis: from art to scienceJerome Duclercq
Universite de Picardie Jules Verne, Unité de Recherche EA3900 Laboratoire Androgenèse et Biotechnologie, Faculte des Sciences, 33 rue Saint Leu, 80039 Amiens, France
Trends Plant Sci 16:597-606. 2011In vitro shoot organogenesis and plant regeneration are crucial for both plant biotechnology and the fundamental study of plant biology...
- Rac GTPase signaling during embryonic salivary gland branching morphogenesisSharon Sequeira; Fiscal Year: 2012..The knowledge gained from this project on the signaling mechanisms underlying early salivary gland organogenesis will be of considerable significance to the fields of tissue engineering and regenerative medicine and to ..
- Mouse models of genomic instability and birth defectsCATHERINE ELIZABETH KEEGAN; Fiscal Year: 2013..In Aim 2, the hypothesis that normal Acd function is critical during early organogenesis will be tested using an inducible targeted knockout of the Acd gene during development...
- Mechanisms of TGFB Signal TransductionAkiko Hata; Fiscal Year: 2013..patterning, left-right asymmetry, neurogenesis, somite and skeletal development, limb patterning, and organogenesis. Germline mutations of the type II BMP receptor (BMPRII) genes are associated with IPAH...
- MECHANISMS OF FGF RECEPTOR REGULATION AND SIGNALINGMoosa Mohammadi; Fiscal Year: 2013..FGF7, FGF8, and FGF9 subfamilies play essential roles in spermatogenesis, mesoderm induction, somitogenesis, organogenesis, and pattern formation, whereas the FGF19 subfamily acts in an endocrine fashion to regulate major metabolic ..
- Genetic Control of Axial Patterning in Drosophila EyeAmit Singh; Fiscal Year: 2010DESCRIPTION (provided by applicant): During organogenesis axial patterning is essential for growth and development...
- Molecular Analysis of GnRH ActionMark S Roberson; Fiscal Year: 2012..developmental abnormalities associated with the loss of ERKs on cell lineage specification during pituitary organogenesis. We will directly examine the ability of GnRH to promote gene transcription in the absence of ERKs in vivo, ..
- A PANHYPOPITUITARY MOUSE MUTATIONSally A Camper; Fiscal Year: 2013..goal is that a molecular understanding of this common birth defect will yield 1) fundamental information about organogenesis, 2) diagnoses with value for predicting risk and monitoring progression, and 3) provide insight about ..
- ANALYSIS OF CHROMATIN REMODELING IN MAMMARY GLAND DEVELOPMENT USING TILING ARRAYSMonique Rijnkels; Fiscal Year: 2009..they will provide a foundation for understanding epigenetic changes that determine differentiation and organogenesis of specific tissues...
- Regulation of TGF-beta Signaling and Embryonic Development by GTPasesGerald H Thomsen; Fiscal Year: 2010..The GTPBP genes are expressed during early Xenopus embryogenesis and during subsequent organogenesis of somites, blood, heart and nervous system...
- Cytotoxic-T-Lymphocyte (CTL) Therapy of AMLBruce R Blazar; Fiscal Year: 2013..LN organogenesis is dependent upon lymphotoxin-[unreadable]1[unreadable]2, expressed on activated T-cells, B-cells and lymphoid ..
- Cell Specific Expression in the Pituitary GlandSally A Camper; Fiscal Year: 2013..of these transcription factors has advanced our understanding of the genetic hierarchy that controls pituitary organogenesis. To understand the mechanisms that underlie congenital pituitary hypoplasia, links need to be made between ..
- Plexin signalling in melanocyte biology and melanoma progressionGlynis A Scott; Fiscal Year: 2013..multiple biologic processes, including cell adhesion and migration, neurite extension, immune function, organogenesis, and tumor progression...
- Inducible Dysplastic Nephropathy in B2-Deficient MiceSamir S El-Dahr; Fiscal Year: 2013..A physiological cross-talk operates between the tumor suppressor protein, p53, and the BdkrB2 during renal organogenesis. Thus, while BdkrB2 is a target for p53-mediated transcriptional activation, BdkrB2 is required to prevent the ..
- Molecular and Cellular Regulation of Mammalian Renal Medulla DevelopmentJing Yu; Fiscal Year: 2013..mechanisms required for renal medulla formation is important not only for the understanding of normal kidney organogenesis and physiology, but will also guide efforts in the development of new strategies of the repair and ..
- Small Molecule-Mediated Augmentation of Kidney RegenerationNeil A Hukriede; Fiscal Year: 2010..hallmarks of renal tubular regeneration in AKI is the reactivation of embryonic genes normally required during organogenesis. We therefore hypothesized that any treatment that causes expansion of these progenitor cells during embryonic ..
- The Role of TAF4b in Spermatogonial Stem Cell Maintenance and Self-RenewalEric Gustafson; Fiscal Year: 2013..gene expression programs involved in diverse developmental events associated with multicellularity and organogenesis. The diversification of core transcription machinery is most notable in the germline where germ cell-specific ..
- Mechanism of CTIP2 action in mouse epidermal homeostasis and barrier formation, ARUP K INDRA; Fiscal Year: 2012..it will, for the first time, reveal the cellular and molecular mechanisms by which CTIP2 regulates skin organogenesis, EPB formation, and tissue homeostasis...
- Analysis of the Role of Sprouty Genes in Tooth DevelopmentOphir Klein; Fiscal Year: 2009..our understanding of the molecular pathways that control epithelial-mesenchymal interactions during tooth organogenesis and may help lead to innovative treatments for patients with dental defects, including even the possibility of ..
- RENAL DISEASEMARC RANDALL HAMMERMAN; Fiscal Year: 2013..core services to support a wide range of research endeavors including organ culture and transplantation (organogenesis);provides expertise and advice for investigators wishing to study diverse aspects of renal development, ..
- Molecular Mechanisms of Histone AcetyltransferasesJohn M Denu; Fiscal Year: 2012..into diverse cell types, how penetrance of disease is modulated by nutrition and environment, and how organogenesis, tissue formation, and aging occur...
- Retinal Cell-Fate Determination and Pattern FormationGraeme Mardon; Fiscal Year: 2012..and So mediate the transition from determination to differentiation and thereby act at a critical junction in organogenesis. Our proposal focuses on understanding the role of these six genes in a well-characterized genetic system, the ..
- TOX, a Novel Regulator of Thymocyte SelectionJONATHAN G KAYE; Fiscal Year: 2013..that TOX plays roles outside the thymus, including an obligatory role in NK cell development and lymph node organogenesis. We propose here three specific aims to delineate the role and mechanism of action of TOX in development of ..
- Genetic and Transcriptional Control of Spleen DevelopmentLicia Selleri; Fiscal Year: 2013DESCRIPTION (provided by applicant): Organogenesis begins with the specification, positioning and assembly of the cell types specific to an organ into the organ primordium (anlage)...
- TERMINAL DIFFERENTIATION OF THE RENAL EPITHELIUMSamir S El-Dahr; Fiscal Year: 2012..executes its differentiation functions are important basic steps toward understanding the genetic control of organogenesis. The proposed studies have important clinical implications as abnormal renal development is the leading cause ..
- Establishment of epithelial planar cell polarityMarek Mlodzik; Fiscal Year: 2013..Both polarity and ordered patterning are established during organogenesis. Typical PCP examples include aspects of mammalian skin or internal organs, like the inner ear epithelium with ..
- Fetal Programming and Environmental Exposures: Implications for Prenatal Care andJeffrey A Whitsett; Fiscal Year: 2012..the trajectory of prenatal development and pre-term birth, including the effects on: implantation;placentation;organogenesis;and neonatal health, and how to combat these effects;(ii) foster and highlight the research contributions of ..
- Genesis of Epithelial Cell LumensJennifer L Harder; Fiscal Year: 2013..She will also examine delivery of Crumbs3a and glycoproteins to the apical lumen surface during organogenesis of lumen-forming organs in mice using lectin immunohistochemistry and protein immuno-isolation techniques...
- The role of Sprouty genes in development of mammalian external genitaliaOphir D Klein; Fiscal Year: 2012..In this application, we will investigate how Sprouty genes control organogenesis of the mammalian external genitalia...
- Role of Hypoxia in DifferentiationErnestina Schipani; Fiscal Year: 2012..Thus, its relevance is high for both organogenesis and mesenchymal stem cell biology.
- Spatial Regulation of BMP Signaling in Dorsoventral PatterningDavid A Weisblat; Fiscal Year: 2013..of TGF-beta signaling is active throughout vertebrate development, ranging from dorsoventral patterning and organogenesis to the induction of teeth and hair follicles...
- Vitamin A dependent events in urinary tract formation.Cathy Mendelsohn; Fiscal Year: 2009..present in 5-7 million pregnant women worldwide, a condition that in animal models can result in sub-optimal organogenesis. Understanding the role of vitamin A during gestation is thus of great importance...
- A Novel Approach to Decoding Vertebrate Gene RegulationSAMANTHA JEAN RIESENFELD; Fiscal Year: 2013..of the regulatory code is essential for determining the cell-type-specific regulatory circuits that govern organogenesis and contribute to disease...
- GENETIC ANALYSIS OF THE MECHANISMS THAT REGULATE TOOTH MORPHOGENESISGAIL ROBERTA MARTIN; Fiscal Year: 2010..enhance our understanding of the signaling pathways that control epithelial-mesenchymal interactions during organogenesis and will contribute to knowledge about the stem-cell niche in the adult mouse incisor...
- Lymphoid Tissue Inducer/NK22 Cells and Post-transplant Immune RecoveryMichael R Verneris; Fiscal Year: 2013..Lymphoid tissue inducer (LTi) cells are responsible for fetal LN organogenesis and a related cell type is found in adult human SLT. In mice, adult LTi cells mediate SLT repair...
- Molecular and Cellular Controls of Placental MetabolismYoel Sadovsky; Fiscal Year: 2013..Throughout pregnancy and until birth, the placenta is obligatory for embryonic organogenesis, fetal growth, immunological support, and maintenance of healthy maternal-fetal communication, while ..
- Signaling Crosstalk Controlled by a Mad Phosphoserine CodeEDWARD V EIVERS; Fiscal Year: 2013..cascades regulate a diverse range of cellular events such as stem cell maintenance, cell differentiation and organogenesis, while dysfunctional signaling of either pathway can result in human diseases such as cancer...
- LRH-1: Structure-based Approach to Drug Design for Gastrointestinal TumorsJames Bayrer; Fiscal Year: 2013..Understanding of LRH-1 function is fundamental to future research in organogenesis, tumorigenesis, and gastrointestinal homeostasis...
- SEARCH FOR THE MOLECULAR CAUSES OF DIABETIC EMBRYOPATHYMary R Loeken; Fiscal Year: 2013..The malformations occur very early during gestation, at the beginning of organogenesis. In an effort to understand the molecular mechanisms by which maternal diabetes disturbs embryonic development,..
- SOX9 in prostate cancer development and progressionXin Yuan; Fiscal Year: 2012..prostate epithelial cells and in the basal cells of adult prostate, suggesting it is involved in prostate organogenesis and homeostasis...
- Molecular basis for age-related thymic involution and rejuvenationDong Ming Su; Fiscal Year: 2013..Foxn1 mutations have provided information on mechanisms by which Foxn1 regulates TEC function during thymic organogenesis in the embryos. However, the function of Foxn1 in the mature thymus and in natural thymic aging is unclear...
- Bmp-signaling in craniofacial developmentJAMES FRANCIS MARTIN; Fiscal Year: 2012..This research program will directly investigate the function of Bmp4 and Bmp2 in craniofacial organogenesis using conditional gene inactivation studies...
- Methods Development for CVM Cell Migration Study in DrosophilaANGELIKE M STATHOPOULOS; Fiscal Year: 2013..of the embryo to another, effectively controlling cell-cell interactions to drive cell differentiation and organogenesis. The shape of most complex organ systems arises from the directed migration of cohesive cell groups...
- Role of T-box Genes in Mouse DevelopmentVirginia E Papaioannou; Fiscal Year: 2013..the T-box family of transcription factor genes and how they interact and impinge on signaling pathways during organogenesis. The work started with an exploration of the evolution of the gene family and the discovery of previously ..
- p53-Regulation in Liver RegenerationMICHELLE ANN BARTON; Fiscal Year: 2012Renewed organogenesis of the fully differentiated liver is stimulated in response to surgical removal (partial hepatectomy, PHx) or destruction of liver tissue by chemicals or disease...
- The Effects of Ethanol on Amniotic Fluid-derived Stem CellsJENNIFER HIPP; Fiscal Year: 2010..Stem cells maybe used as a tool elucidate mechanisms of ethanol's effect on organogenesis. For the current proposal, we plan to use a particular type of stem cells, amniotic fluid-derived stem cells (..
- Role of FGF10 in liver organogenesis and alcohol-impaired regenerationKASPER SAONUN WANG; Fiscal Year: 2010..We postulate that the mechanism by which alcohol impairs liver regeneration may be due to impaired signaling through the FGF10/FGFR2b pathway we show normally promotes liver regeneration. ..
- Biochemical and Functional Studies of Sall1 in Kidney Development and TBSMICHAEL I RAUCHMAN; Fiscal Year: 2010b>Organogenesis requires the precise temporal and spatial control of gene expression to direct developmental programs that regulate a variety of cellular processes...
- Iron Delivery in the Developing KidneyJonathan M Barasch; Fiscal Year: 2013..The developing kidney requires sufficient iron for optimal organogenesis during pregnancy and in the early postnatal period...
- 6th International Conference on SBDSSridhar Mani; Fiscal Year: 2011..SDS, including genetic testing;and (ii) the molecular function of SBDS in hematopoiesis, leukemogenesis, and organogenesis. The meeting focus is significant from both clinical and scientific perspectives and will hopefully help ..
- Role of microRNAs in mammalian ear development and neurosensory specificationGARRETT ANDREW SOUKUP; Fiscal Year: 2013..proliferation, differentiation and fate specification that ultimately affect morphogenesis, histogenesis and organogenesis in a variety of organisms...
- Molecular Patterning of Mammalian DentitionRulang Jiang; Fiscal Year: 2013..development has long been used as a powerful model system for studying the molecular mechanisms regulating organogenesis and the pathogenic mechanisms of tooth developmental anomalies in humans...
- Function and regulation of T-box factors in C. elegansPeter G Okkema; Fiscal Year: 2010..term goal is to understand the development of the pharynx as a simple model for cell-type specification and organogenesis. The primary focus of this application is on the mechanisms regulating expression and function of the T-box ..
- Standardized Next Generation Transcriptome Profiling Tools for X. TropicalisZhihua Jiang; Fiscal Year: 2013..provide new insights into mechanisms in cell cycle and mitosis, nuclear reprogramming and stem cell biology, organogenesis and tissue remodeling during metamorphosis and regeneration, and thus, deliver an essential model for the ..
- Investigation of Gene Regulation by NF-kappaB Transcription factorsGourisankar Ghosh; Fiscal Year: 2012..been reported to associate with Bcl3 to activate transcription, and as such they play critical roles in immune organogenesis and tolerance...
- Mechanisms of Pbx-directed Genetic &Transcriptional Control of Limb DevelopmentLicia Selleri; Fiscal Year: 2013..Despite their paramount roles in organogenesis and patterning of the body and limb axes, the molecular mechanisms of Hox regulation remain elusive...
- Spatial Segregation of Cell Functioning during Cell MotilityAlan Wells; Fiscal Year: 2013DESCRIPTION (provided by applicant): Induced cell motility functions during organogenesis and wound repair to (re)populate the target space, a situation that is deficient in a number of clinical conditions and in aging individuals...
- Genomic survey of cis-regulatory element function by high-throughput transgenesisRobert M Grainger; Fiscal Year: 2012..hypothesis underlying this proposal is that many developmental processes, including embryonic patterning and organogenesis, are highly conserved among vertebrates, and that the genetic machinery regulating these processes is also ..
- The role of DNA methylation in lens fiber cell terminal differentiationRachel K Tittle; Fiscal Year: 2012..However, the specific role of DNA methylation in terminal differentiation and organogenesis has so far been studied in very few cell types...
- Innovative In Vivo-like Model for Vascular Tissue EngineeringEva Schmelzer; Fiscal Year: 2013..model systems, by analyzing neo-vascularization in an organ-like environment in vitro designed to mimic human organogenesis and that can vary physical conditions, such as flow- and pressure changes in the rhythm of the heart rate...
- Functional and Evolutionary Genomics of Ancient Small RNAsMichael J Axtell; Fiscal Year: 2012..The regulation of specific "target" genes by microRNAs is critical for embryonic development, organogenesis, and stress responses...
- Branching Morphogenesis of Urinary Epithelia: from Genes to Cellular BehaviorsFRANKLIN D COSTANTINI; Fiscal Year: 2013..make a functional ureter, while complex patterns of UB branching morphogenesis are required for normal renal organogenesis. While many genes involved in these events have been identified, the genetic instructions must be translated ..
- The Structural Basis of Shroom-Mediated Cell ContractilityANDREW PAUL VANDEMARK; Fiscal Year: 2013..The regulation of cell architecture and morphology is essential during the course of vertebrate development, organogenesis, and tissue homeostasis...
- PREVENTION OF X-RAY INDUCED MALFORMATIONSMARVIN SODICOFF; Fiscal Year: 1990..The rat is most susceptible to x-ray teratogenesis during the period of early organogenesis. Defects typically affect the head resulting in craniofacial abnormalities e.g...
- ENDOSTATIN RECEPTOR CDNA CLONING AND IONIC SIGNALINGSeth Alper; Fiscal Year: 2001..Angiogenesis is now recognized as a process central to embryonic development, organogenesis and regenerative tissues proliferation, and tumor growth...
- Fourth Symposium Biology Vertebrate Sex DeterminationBlanche Capel; Fiscal Year: 2006..Surprisingly, the mechanisms of testis and ovary organogenesis are proving to be highly diverged and providing exciting insights into the evolution of developmental ..
- NR4A Regulation of Organ MorphogenesisCHRISTOPHER GISSENDANNER; Fiscal Year: 2009..Thus, NHR-6 appears to function as a critical, dualistic transcriptional regulator of organogenesis in C. elegans...
- ARTHRITIS AND MUSCULOSKELETAL DISEASES CENTERDavid Fox; Fiscal Year: 2001..and Aging, 4) Development and Application of Imaging Techniques, 5) Orthopedics and Biomechanics, and 6) Organogenesis. In support of these major programs, funding is requested for none core facilities: 1) Flow Cytometry Core, 2) ..
- SIGNALS FOR RENAL ENDOTHELIAL CAPILLARY MORPHOGENESISJin Chen; Fiscal Year: 2001..Adapted from Investigator's Abstract): Vasculogenesis and angiogenic remodeling are basic requirements for organogenesis and wound healing. For vasculogenesis to occur, the endothelial cell progenitors must assemble properly...
- CONTROL MECHANISMS IN DIABETES AND NORMAL METABOLISMBOYD METZGER; Fiscal Year: 1991The program tests the proposition that normal growth and organogenesis in the postimplantation embryo are linked to the integrity of ongoing metabolism...
- GLUCOSE-DEPENDENT GLUT-1 EXPRESSION IN EMBRYONIC HEARTIDA WASHINGTON; Fiscal Year: 2003..heart and is critical for delivery of glucose to embryonic heart cells for normal metabolism and growth during organogenesis. Glut-1 glucose uptake and expression are influenced in adult cells by glucose concentration and duration of ..
- SCREEN FOR LYMPHOID MUTANTSNikolaus Trede; Fiscal Year: 2004..mouse mutants and "knock-out" mice, several of the important genes in lymphocyte development and thymic organogenesis have been recently characterized...