organogenesis

Summary

Summary: Formation of differentiated cells and complicated tissue organization to provide specialized functions.

Top Publications

  1. pmc Generation and regeneration of cells of the liver and pancreas
    Kenneth S Zaret
    Epigenetics and Progenitor Cells Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Science 322:1490-4. 2008
  2. pmc Preparing for the first breath: genetic and cellular mechanisms in lung development
    Edward E Morrisey
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 18:8-23. 2010
  3. doi Cytokinin modulates endocytic trafficking of PIN1 auxin efflux carrier to control plant organogenesis
    Peter Marhavy
    Department of Plant Systems Biology, VIB, Technologiepark 927, B 9052 Gent, Belgium
    Dev Cell 21:796-804. 2011
  4. doi Pancreas organogenesis: from bud to plexus to gland
    Fong Cheng Pan
    Dev Dyn 240:530-65. 2011
  5. doi Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles
    Elina A Kiss
    Institute of Medical Microbiology and Hygiene, University of Freiburg Medical Center, Freiburg, Germany
    Science 334:1561-5. 2011
  6. pmc Lung organogenesis
    David Warburton
    The Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, California, USA
    Curr Top Dev Biol 90:73-158. 2010
  7. ncbi Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system
    Thomas J Carroll
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Dev Cell 9:283-92. 2005
  8. pmc Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis
    S M Knox
    Matrix and Morphogenesis Unit, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Drive, Bethesda, MD 20892, USA
    Science 329:1645-7. 2010
  9. ncbi Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis
    Xue Li
    Howard Hughes Medical Institute, School and Department of Medicine, UCSD, 9500 Gilman Drive, Room 345, La Jolla, California 92093 0648, USA
    Nature 426:247-54. 2003
  10. ncbi Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis
    Victoria V Lunyak
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, CA 92093 0648, USA
    Science 317:248-51. 2007

Research Grants

Detail Information

Publications301 found, 100 shown here

  1. pmc Generation and regeneration of cells of the liver and pancreas
    Kenneth S Zaret
    Epigenetics and Progenitor Cells Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Science 322:1490-4. 2008
    ....
  2. pmc Preparing for the first breath: genetic and cellular mechanisms in lung development
    Edward E Morrisey
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 18:8-23. 2010
    ....
  3. doi Cytokinin modulates endocytic trafficking of PIN1 auxin efflux carrier to control plant organogenesis
    Peter Marhavy
    Department of Plant Systems Biology, VIB, Technologiepark 927, B 9052 Gent, Belgium
    Dev Cell 21:796-804. 2011
    ..identified an alternative mode of cytokinin action that uses endocytic trafficking as a means to direct plant organogenesis. This activity occurs downstream of known cytokinin receptors but through a branch of the cytokinin signaling ..
  4. doi Pancreas organogenesis: from bud to plexus to gland
    Fong Cheng Pan
    Dev Dyn 240:530-65. 2011
    ....
  5. doi Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles
    Elina A Kiss
    Institute of Medical Microbiology and Hygiene, University of Freiburg Medical Center, Freiburg, Germany
    Science 334:1561-5. 2011
    ..Our results establish a molecular link between nutrients and the formation of immune system components required to maintain intestinal homeostasis and resistance to infections...
  6. pmc Lung organogenesis
    David Warburton
    The Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, California, USA
    Curr Top Dev Biol 90:73-158. 2010
    ....
  7. ncbi Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system
    Thomas J Carroll
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Dev Cell 9:283-92. 2005
    ..Together these findings suggest that Wnt9b is a common organizing signal regulating diverse components of the mammalian urogenital system...
  8. pmc Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis
    S M Knox
    Matrix and Morphogenesis Unit, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Drive, Bethesda, MD 20892, USA
    Science 329:1645-7. 2010
    ..However, the mechanisms by which epithelial progenitor cells are maintained during organogenesis are poorly understood...
  9. ncbi Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis
    Xue Li
    Howard Hughes Medical Institute, School and Department of Medicine, UCSD, 9500 Gilman Drive, Room 345, La Jolla, California 92093 0648, USA
    Nature 426:247-54. 2003
    ..mechanistic relationship between gene activation and repression events is a central question in mammalian organogenesis, as exemplified by the evolutionarily conserved sine oculis (Six), eyes absent (Eya) and dachshund (Dach) ..
  10. ncbi Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis
    Victoria V Lunyak
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, CA 92093 0648, USA
    Science 317:248-51. 2007
    ..These data suggest that transcription of interspersed repetitive sequences may represent a developmental strategy for the establishment of functionally distinct domains within the mammalian genome to control gene activation...
  11. doi Next-generation regenerative medicine: organogenesis from stem cells in 3D culture
    Yoshiki Sasai
    Neurogenesis and Organogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Cell Stem Cell 12:520-30. 2013
    ..For some tissues, epithelial-mesenchymal interactions can also be manipulated in coculture to guide organogenesis. This new area of stem cell research-the spatiotemporal control of dynamic cellular interactions-will open a ..
  12. pmc Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis
    Vicki Plaks
    Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143 0452, USA
    Cell Rep 3:70-8. 2013
    ..Loss-of-function and depletion experiments of Lgr5(+) cells from transplanted MECs or from pubertal MGs revealed that these cells are not only sufficient but also necessary for postnatal mammary organogenesis.
  13. doi Laminins
    Madeleine Durbeej
    Department of Experimental Medical Science, University of Lund, Sweden
    Cell Tissue Res 339:259-68. 2010
    ..Laminins are vital for many physiological functions. They are essential for early embryonic development and organogenesis and have crucial functions in several tissues including muscle, nerve, skin, kidney, lung, and the vasculature...
  14. pmc Vertebrate endoderm development and organ formation
    Aaron M Zorn
    Division of Developmental Biology, Cincinnati Children s Research Foundation and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Annu Rev Cell Dev Biol 25:221-51. 2009
    ..We review this progress with a focus on early stages of endoderm organogenesis including endoderm formation, gut tube morphogenesis and patterning, and organ specification...
  15. doi Origin of stem cells in organogenesis
    J M W Slack
    Stem Cell Institute, University of Minnesota, McGuire Translational Research Facility, 2001 6th Street SE, Minneapolis, MN 55455, USA
    Science 322:1498-501. 2008
    ..Possible explanations for the existence of such cells, and the issue of whether they also exist in vivo, are discussed...
  16. pmc Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish
    Jun Chen
    Laboratory of Functional Genomics, Laboratory of Molecular and Developmental Immunology, Laboratory of Control of p53 Pathway, Institute of Molecular and Cell Biology, Proteos, Singapore 138673
    Genes Dev 19:2900-11. 2005
    ..However, there is currently no direct genetic evidence to show if or how the p53 pathway functions during organogenesis. Here we present evidence to show that the zebrafish def (digestive-organ expansion factor) gene encodes a ..
  17. ncbi T-box genes in vertebrate development
    L A Naiche
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Annu Rev Genet 39:219-39. 2005
    ..regulation of the development of extraembryonic structures, embryonic patterning, and many aspects of organogenesis. They are unusual in displaying dosage sensitivity in most instances...
  18. doi Primary cilia and organogenesis: is Hedgehog the only sculptor?
    Evangelia Tasouri
    Interdisciplinary Center for Neurosciences, Institute of Anatomy and Cell Biology, University of Heidelberg, Im Neuenheimer Feld 307, Heidelberg, Germany
    Cell Tissue Res 345:21-40. 2011
    ..critical dependency of signal transduction of the Hedgehog pathway upon functionally intact cilia to regulate organogenesis. Another common theme is the role that the cilium plays, not necessarily in the determination of the embryonic ..
  19. ncbi Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis
    Henrique Veiga-Fernandes
    Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 446:547-51. 2007
    Normal organogenesis requires co-ordinate development and interaction of multiple cell types, and is seemingly governed by tissue specific factors...
  20. pmc Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis
    Humphrey H C Yao
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    Dev Dyn 230:210-5. 2004
    ..Thus, we propose that WNT4 acts through FST to regulate vascular boundaries and maintain germ cell survival in the ovary...
  21. ncbi Stabilization of beta-catenin impacts pancreas growth
    Patrick W Heiser
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Development 133:2023-32. 2006
    ..Robust stabilization of beta-catenin during early organogenesis drives changes in hedgehog and Fgf10 signaling and induces a loss of Pdx1 expression in early pancreatic ..
  22. pmc MicroRNA networks in mouse lung organogenesis
    Jie Dong
    Division of General Thoracic Surgery, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, Minnesota, USA
    PLoS ONE 5:e10854. 2010
    ..MiRNA networks and their regulation of messenger RNA (mRNA) translation and protein expression in specific biological processes are poorly understood...
  23. pmc Biliary tree stem cells, precursors to pancreatic committed progenitors: evidence for possible life-long pancreatic organogenesis
    Yunfang Wang
    Department of Cell Biology and Physiology, Program in Molecular Biology and Biotechnology, Lineberger Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Stem Cells 31:1966-79. 2013
    ..The biliary tree-derived stem cells and their connections to pancreatic committed progenitors constitute a biological framework for life-long pancreatic organogenesis.
  24. pmc Retinoic acid synthesis and signaling during early organogenesis
    Gregg Duester
    Burnham Institute for Medical Research, Development and Aging Program, La Jolla, CA 92037, USA
    Cell 134:921-31. 2008
    Retinoic acid, a derivative of vitamin A, is an essential component of cell-cell signaling during vertebrate organogenesis. In early development, retinoic acid organizes the trunk by providing an instructive signal for posterior ..
  25. pmc Canopy1, a positive feedback regulator of FGF signaling, controls progenitor cell clustering during Kupffer's vesicle organogenesis
    Takaaki Matsui
    Gene Regulation Research, Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Nara 630 0101, Japan
    Proc Natl Acad Sci U S A 108:9881-6. 2011
    ..Our results therefore uncover both a previously unidentified role of FGF signaling during vertebrate organogenesis and a regulatory mechanism underlying cell cluster formation, which is an indispensable step for formation of ..
  26. pmc The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis
    Marc Sylva
    Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 6:e22616. 2011
    ..Taken together, these observations show that Fstl1 is a crucial regulator in BMP signalling during mouse development...
  27. pmc Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice
    Rolf Grabner
    Institute for Vascular Medicine, Friedrich Schiller University of Jena, 07743 Jena, Germany
    J Exp Med 206:233-48. 2009
    ..Thus, the LTbetaR pathway has a major role in shaping the immunological characteristics and overall integrity of the arterial wall...
  28. pmc Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney
    Michelle Self
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    EMBO J 25:5214-28. 2006
    ..We propose that in the developing kidney, Six2 activity is required for maintaining the mesenchymal progenitor population in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud...
  29. ncbi Fgf10 regulates hepatopancreatic ductal system patterning and differentiation
    P Duc Si Dong
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and the Diabetes Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94158, USA
    Nat Genet 39:397-402. 2007
    During organogenesis, the foregut endoderm gives rise to the many different cell types that comprise the hepatopancreatic system, including hepatic, pancreatic and gallbladder cells, as well as the epithelial cells of the ..
  30. pmc Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron
    Hui Teng Cheng
    Department of Molecular Biology and Pharmacology at Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, St Louis, MO 63110, USA
    Development 134:801-11. 2007
    ..These results establish distinct (non-redundant), instructive roles for Notch receptors in nephron segmentation...
  31. ncbi Mechanisms of ectodermal organogenesis
    Johanna Pispa
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014, Helsinki, Finland
    Dev Biol 262:195-205. 2003
    ..The molecular signals regulating organogenesis, such as molecules in the FGF, TGFbeta, Wnt, and hedgehog families, regulate the development of all ectodermal ..
  32. pmc Opposing Wnt pathways orient cell polarity during organogenesis
    Jennifer L Green
    Howard Hughes Medical Institute Division of Biology, California Institute of Technology, Mail Code 156 29, Pasadena, CA 91125, USA
    Cell 134:646-56. 2008
    ..Thus, tissue polarity is determined by the integration of multiple Wnt pathways...
  33. doi Vertebrate limb bud development: moving towards integrative analysis of organogenesis
    Rolf Zeller
    Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Nat Rev Genet 10:845-58. 2009
    The limb bud is of paradigmatic value to understanding vertebrate organogenesis. Recent genetic analysis in mice has revealed the existence of a largely self-regulatory limb bud signalling system that involves many of the pathways that ..
  34. pmc The FoxA factors in organogenesis and differentiation
    Klaus H Kaestner
    Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6145, United States
    Curr Opin Genet Dev 20:527-32. 2010
    The genetic analysis of the Foxa genes in both total and conditional mutant mice has clearly established that organogenesis of multiple systems is controlled by this subfamily of winged helix transcription factors...
  35. ncbi Coordinated control of cell adhesion, polarity, and cytoskeleton underlies Hox-induced organogenesis in Drosophila
    Bridget Lovegrove
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom
    Curr Biol 16:2206-16. 2006
    ..Much research has been devoted to the search for these targets and the characterization of their roles in organogenesis. This has shown that the direct targets of Hox activation are often transcription factors or signaling ..
  36. doi Histone deacetylase 3 (hdac3) is specifically required for liver development in zebrafish
    Muhammad Farooq
    Department of Biological Sciences, National University of Singapore, 117543, Singapore
    Dev Biol 317:336-53. 2008
    ..These results revealed a novel and specific role of hdac3 in liver development and the distinct functions between hdac1 and hdac3 in zebrafish embryonic development...
  37. pmc Comparative transcriptome analysis reveals vertebrate phylotypic period during organogenesis
    Naoki Irie
    Laboratory for Evolutionary Morphology, RIKEN Center for Developmental Biology, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Nat Commun 2:248. 2011
    ..followed by diversifying later stages, and the 'hourglass' model, in which constraints are imposed to conserve organogenesis stages, which is called the phylotypic period...
  38. doi The Fox genes in the liver: from organogenesis to functional integration
    John Le Lay
    Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
    Physiol Rev 90:1-22. 2010
    ..We discuss the biochemical and genetic roles of Foxa, Foxl1, Foxm1, and Foxo, as these have been shown to regulate many processes throughout the life of the organ, controlling both formation and function of the liver...
  39. pmc Feather regeneration as a model for organogenesis
    Sung Jan Lin
    Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Children s Hospital and National Taiwan University Hospital, No 8 Chung Shan South Road, Taipei, Taiwan
    Dev Growth Differ 55:139-48. 2013
    In the process of organogenesis, different cell types form organized tissues and tissues are integrated into an organ...
  40. pmc Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis
    Sabine Jurado
    St Vincent s Institute of Medical Research, Fitzroy, Australia
    PLoS Genet 6:e1001170. 2010
    ..Altogether, the data indicate that, in addition to its role in the DNA base damage response, ASCIZ has separate developmental functions as an essential regulator of respiratory organogenesis.
  41. pmc Def functions as a cell autonomous factor in organogenesis of digestive organs in zebrafish
    Ting Tao
    Key Laboratory for Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang Province, China
    PLoS ONE 8:e58858. 2013
    ..However, the molecular mechanism for the involvement of Def in the organogenesis of digestive organs is still largely unknown...
  42. ncbi p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation
    Johanna Laurikkala
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Development 133:1553-63. 2006
    ..We also demonstrate that BMP2, BMP7 and FGF10 are potent inducers of p63 in cultured tissue explants. Hence, we suggest that p63 regulates the morphogenesis of surface ectoderm and its derivatives via multiple signalling pathways...
  43. pmc A comparative study of prenatal development in Miniopterus schreibersii fuliginosus, Hipposideros armiger and H. pratti
    Zhe Wang
    School of Life Sciences, East China Normal University, Shanghai 200062, PR China
    BMC Dev Biol 10:10. 2010
    ..Bats comprise the second largest order of mammals. However, there are far fewer morphological studies of post-implantation embryonic development than early embryonic development in bats...
  44. pmc Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways
    Bryan Lo
    Genentech, South San Francisco, CA 94080, USA
    J Cell Biol 199:1117-30. 2012
    ..Combining culture of embryonic tissues with genetic manipulation and chemical genetics thus provides a powerful approach to unraveling developmental programs and understanding cancer initiation...
  45. pmc PRC2 during vertebrate organogenesis: a complex in transition
    Issam Aldiri
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Dev Biol 367:91-9. 2012
    During organogenesis, tissues expand in size and eventually acquire consistent ratios of cells with dazzling diversity in morphology and function...
  46. doi Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish
    XuBo Niu
    Key Laboratory for Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou, PR China
    Dev Biol 367:197-207. 2012
    ..Although it has been studied in depth in yeast and cultured cells, the role of COPII in organogenesis in a multicellular organism has not...
  47. doi Osteoclasts in bone modeling, as revealed by in vivo imaging, are essential for organogenesis in fish
    Masahiro Chatani
    Department of Biological Information, Tokyo Institute of Technology, Midori ku, Yokohama, Japan
    Dev Biol 360:96-109. 2011
    ..Here we showed the important role of osteoclasts in organogenesis by establishing osteoclast-specific transgenic medaka lines and by using a zebrafish osteoclast-deficient line...
  48. pmc Sfrp5 modulates both Wnt and BMP signaling and regulates gastrointestinal organogenesis [corrected] in the zebrafish, Danio rerio
    Carsten Stuckenholz
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e62470. 2013
    ..We show that Sfrp5 inhibits both canonical and non-canonical Wnt signaling during embryonic and endodermal development, resulting in endodermal abnormalities...
  49. ncbi Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway
    Simon D Bamforth
    Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 36:1189-96. 2004
    ..We propose that an abnormal Nodal-Pitx2c pathway represents a unifying mechanism for the cardiovascular malformations observed in Cited2(-/-) mice, and that such malformations may be the sole manifestation of a laterality defect...
  50. ncbi Roles of PDGF in animal development
    Renée V Hoch
    Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Development 130:4769-84. 2003
    ..elegans, Drosophila, Xenopus, zebrafish and mouse. Early data from these different systems suggest that some functions of PDGFs have been evolutionarily conserved...
  51. pmc Organogenesis and tumorigenesis: insight from the JAK/STAT pathway in the Drosophila eye
    Ying Hsuan Wang
    Department of Life Science and Institute of Molecular Biology, National Chung Cheng University, Chia Yi, Taiwan
    Dev Dyn 239:2522-33. 2010
    ..In this review, we focus on the functions and regulation of the JAK/STAT pathway during eye development and provide some insights into the study of this pathway in tumorigenesis...
  52. pmc Stem cell activation by light guides plant organogenesis
    Saiko Yoshida
    Institute of Plant Sciences, University of Bern, CH 3013 Bern, Switzerland
    Genes Dev 25:1439-50. 2011
    ..In contrast to common wisdom over the last 150 years, the light environment controls the initiation of lateral organs by regulating two key hormones: auxin and cytokinin...
  53. pmc Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors
    Pallavi Bhattaram
    Department of Cell Biology, and Orthopaedic and Rheumatologic Research Center, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio 44195, USA
    Nat Commun 1:9. 2010
    During organogenesis, neural and mesenchymal progenitor cells give rise to many cell lineages, but their molecular requirements for self-renewal and lineage decisions are incompletely understood...
  54. pmc The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling
    Sangho Yu
    Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
    Dev Dyn 240:384-93. 2011
    ..Thus, CXCR7 is involved in semilunar valve development, possibly by regulating BMP signaling, and may contribute to aortic and pulmonary valve stenosis...
  55. ncbi Organogenesis of peripheral lymphoid organs
    Shin ichi Nishikawa
    RIKEN Center for Developmental Biology, Chou ku, Kobe, Japan
    Immunol Rev 195:72-80. 2003
    ..that lymphotoxin alpha (LTalpha) knockout mice lack peripheral lymphoid tissues reformed the study of organogenesis of peripheral lymphoid tissues from a research field that was solely descriptive and dependent on histological ..
  56. pmc A Sall4 mutant mouse model useful for studying the role of Sall4 in early embryonic development and organogenesis
    Madhuri Warren
    Genesis 45:51-8. 2007
    ....
  57. pmc Repulsion by Slit and Roundabout prevents Shotgun/E-cadherin-mediated cell adhesion during Drosophila heart tube lumen formation
    EDGARDO SANTIAGO-MARTINEZ
    Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    J Cell Biol 182:241-8. 2008
    ..Our data show that Slit and Robo pathways function in lumen formation as a repulsive signal to antagonize E-Cad-mediated cell adhesion...
  58. ncbi Molecular principles of hair follicle induction and morphogenesis
    Ruth Schmidt-Ullrich
    Department of Cell Growth and Differentiation, Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Bioessays 27:247-61. 2005
    ..interactions, and can be divided into morphologically distinguishable stages (induction, organogenesis and cytodifferentiation)...
  59. doi Transcriptome analysis of early organogenesis in human embryos
    Hai Fang
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine SJTU SM, Shanghai 200025, China
    Dev Cell 19:174-84. 2010
    ..Here, we report transcriptome profiles of human early embryos covering development during the first third of organogenesis. We identified two major categories of genes, displaying gradually reduced or gradually increased expression ..
  60. doi Kidney development: two tales of tubulogenesis
    Melissa Little
    Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia
    Curr Top Dev Biol 90:193-229. 2010
    ..individual players and codependent interrelationships between a branched and non-branched tubular network make organogenesis in the kidney unique. Here we review both what is known and remains to be understood in kidney tubulogenesis.
  61. pmc Four-dimensional realistic modeling of pancreatic organogenesis
    Yaki Setty
    Computational Biology Group, Microsoft Research, Cambridge CB3 0FB, United Kingdom
    Proc Natl Acad Sci U S A 105:20374-9. 2008
    b>Organogenesis, the process by which organs develop from individual precursor stem cells, requires that the precursor cells proliferate, differentiate, and aggregate to form a functioning structure...
  62. pmc Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes
    S W Davis
    University of Michigan Medical School, Ann Arbor, MI 41809 5618, USA
    Mol Cell Endocrinol 323:4-19. 2010
    Defects in pituitary gland organogenesis are sometimes associated with congenital anomalies that affect head development. Lesions in transcription factors and signaling pathways explain some of these developmental syndromes...
  63. pmc FACS-assisted microarray profiling implicates novel genes and pathways in zebrafish gastrointestinal tract development
    Carsten Stuckenholz
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Gastroenterology 137:1321-32. 2009
    ..To identify differentially regulated genes important in gastrointestinal organogenesis, we profiled the transcriptome of the zebrafish developing gastrointestinal tract.
  64. pmc Restriction of hepatic competence by Fgf signaling
    Donghun Shin
    Department of Biochemistry and Biophysics, Liver Center, Institute for Regeneration Medicine, University of California, San Francisco, CA 94158, USA
    Development 138:1339-48. 2011
    ..These data provide in vivo evidence that endodermal cells outside the liver-forming region retain hepatic competence and show that an extrinsic signal, Fgf10a, negatively regulates hepatic competence...
  65. pmc Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways
    Rathi D Thiagarajan
    Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia
    PLoS ONE 6:e17286. 2011
    ..a further 92 compartment-enriched genes able to subcompartmentalise key processes during murine renal organogenesis spatially or ontologically...
  66. ncbi Serotonin transporter function is an early step in left-right patterning in chick and frog embryos
    Takahiro Fukumoto
    Cytokine Biology Department, The Forsyth Institute, Harvard Medical School, Boston, Mass 02115, USA
    Dev Neurosci 27:349-63. 2005
    ..Taken together our data characterize two new right-sided markers in chick gastrulation, identify a novel, early component of the left-right pathway in two vertebrate species, and reveal a new biological role for serotonin transport...
  67. ncbi An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
    Gerard Eberl
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 5:64-73. 2004
    ..This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues...
  68. ncbi MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines
    Nadine Baroukh
    INSERM, U145, Nice, F 06107, France
    J Biol Chem 282:19575-88. 2007
    ....
  69. ncbi Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter
    Fiona Rae
    Institute for Molecular Bioscience and ARC Special Research Centre for Functional and Applied Genomics, University of Queensland, Brisbane, Queensland 4072, Australia
    Dev Biol 308:232-46. 2007
    All solid organs contain resident monocyte-derived cells that appear early in organogenesis and persist throughout life. These cells are critical for normal development in some organs...
  70. pmc Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium
    Yi Hui Chen
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center and Hospital, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9176, USA
    BMC Dev Biol 8:75. 2008
    ..Msx1 and Msx2 have well-documented roles in mediating epithelial-mesenchymal interactions during organogenesis. Given that both Msx1 and Msx2 are crucial downstream effectors of Bmp signaling, we investigated whether Msx1 ..
  71. ncbi An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells
    Amelie Calmont
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA
    Dev Cell 11:339-48. 2006
    ..The finding of separate pathways for endoderm tissue specification and growth provides insights for guiding cellular regeneration and stem cell differentiation...
  72. ncbi Molecular genetic cascades for external genitalia formation: an emerging organogenesis program
    G Yamada
    Center for Animal Resources and Development CARD, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Dev Dyn 235:1738-52. 2006
    ..Development of the male and female external genitalia is also reviewed...
  73. ncbi Kidney development and disease in the zebrafish
    Iain A Drummond
    Department of Medicine, Harvard Medical School and Renal Unit, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    J Am Soc Nephrol 16:299-304. 2005
    ..This short review outlines recent progress in applying the zebrafish pronephros to issues of human health and development...
  74. ncbi Functional microarray analysis of mammary organogenesis reveals a developmental role in adaptive thermogenesis
    Stephen R Master
    Department of Cancer Biology and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    Mol Endocrinol 16:1185-203. 2002
    The use of DNA microarrays to study vertebrate organogenesis presents unique analytical challenges compared with expression profiling of homogeneous cell populations...
  75. pmc GATA4 and GATA6 control mouse pancreas organogenesis
    Manuel Carrasco
    Centro Andaluz de Biologia Molecular y Medicina Regenerativa CABIMER, Sevilla, Spain
    J Clin Invest 122:3504-15. 2012
    Recently, heterozygous mutations in GATA6 have been found in neonatal diabetic patients with failed pancreatic organogenesis. To investigate the roles of GATA4 and GATA6 in mouse pancreas organogenesis, we conditionally inactivated these ..
  76. pmc Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration
    Fong Cheng Pan
    Vanderbilt University Program in Developmental Biology, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Development 140:751-64. 2013
    Pancreatic multipotent progenitor cells (MPCs) produce acinar, endocrine and duct cells during organogenesis, but their existence and location in the mature organ remain contentious...
  77. doi Organogenesis for kidney regeneration
    Shinya Yokote
    Project Laboratory for Kidney Regeneration, Department of Internal Medicine, Institute of DNA Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Curr Opin Organ Transplant 18:186-90. 2013
    ....
  78. pmc Direct control of the proneural gene atonal by retinal determination factors during Drosophila eye development
    Miho Tanaka-Matakatsu
    Ben May Department for Cancer Research, The University of Chicago, 929 E 57th Street, Chicago, IL 60637, USA
    Dev Biol 313:787-801. 2008
    ..These results demonstrate a direct mechanism by which the RD factors regulate ato expression and suggest an important role of Dpp in the activation of ato 3' enhancer is to regulate the levels of RD factors...
  79. doi Organogenesis of the vertebrate heart
    Lucile Miquerol
    Aix Marseille Universite, Developmental Biology Institute of Marseille Luminy, France
    Wiley Interdiscip Rev Dev Biol 2:17-29. 2013
    b>Organogenesis of the vertebrate heart involves a complex sequence of events initiating with specification and differentiation of myocardial and endocardial cells in anterior lateral mesoderm shortly after gastrulation, followed by ..
  80. ncbi Thymus organogenesis and development of the thymic stroma
    Craig S Nowell
    Institute for Stem Cell Research, University of Edinburgh, UK
    Methods Mol Biol 380:125-62. 2007
    ..Here, we describe the structural and phenotypic attributes of the thymic stroma, and review current cellular and molecular understanding of thymus organogenesis.
  81. doi Transcriptional control of mammalian pancreas organogenesis
    David A Cano
    Endocrinology Unit, Instituto de Biomedicina de Sevilla IBiS, Hospital Universitario Virgen del Rocío Consejo Superior de Investigaciones Científicas Universidad de Sevilla, Seville, Spain
    Cell Mol Life Sci 71:2383-402. 2014
    ..the last decade, significantly advancing our understanding of the molecular mechanisms that control pancreas organogenesis. This growth has been fueled, in part, by the need to generate new therapeutic approaches for the treatment of ..
  82. doi Transcriptional regulation of thymus organogenesis and thymic epithelial cell differentiation
    Nancy R Manley
    Department of Genetics, University of Georgia Athens, Georgia, USA
    Prog Mol Biol Transl Sci 92:103-20. 2010
    ..thymus, several key transcription factors have been identified that are critical for various aspects of thymus organogenesis and thymic epithelial cell (TEC) differentiation...
  83. ncbi Making or breaking the heart: from lineage determination to morphogenesis
    Deepak Srivastava
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics and Biochemistry, University of California, San Francisco, CA 94158, USA
    Cell 126:1037-48. 2006
    ....
  84. pmc Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms
    Qian Qin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Res 22:90-106. 2012
    ..Further understanding of the mechanisms by which Twist1 promotes metastasis and identification of Twist1 functional modulators may hold promise for developing new strategies to inhibit EMT and cancer metastasis...
  85. pmc Ectopic gene expression and organogenesis in Arabidopsis mutants missing BRU1 required for genome maintenance
    Yusuke Ohno
    Bioscience and Biotechnology Center, Nagoya University, Chikusa, Nagoya 464 8601, Japan
    Genetics 189:83-95. 2011
    ..bru1 mutants exhibited adventitious organogenesis, probably due to the misexpression of such developmental regulators...
  86. doi Organogenesis in a dish: modeling development and disease using organoid technologies
    Madeline A Lancaster
    IMBA Institute of Molecular Biotechnology of the Austrian Academy of Science Vienna 1030, Austria
    Science 345:1247125. 2014
    ..Furthermore, they have potential for drug testing and even future organ replacement strategies. Here, we summarize this rapidly evolving field and outline the potential of organoid technology for future biomedical research. ..
  87. pmc WNT/beta-catenin signaling in nephron progenitors and their epithelial progeny
    Kai M Schmidt-Ott
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Kidney Int 74:1004-8. 2008
    ..We review current evidence on the WNT/beta-catenin/TCF/Lef1 signaling pathway in kidney epithelial development and discuss the potential implication of non-canonical WNT signaling and WNT-independent events...
  88. pmc Mechanisms of thymus organogenesis and morphogenesis
    Julie Gordon
    Department of Genetics, University of Georgia, Athens, Georgia 30602, USA
    Development 138:3865-78. 2011
    ..T cell differentiation within the thymus has been an area of intense investigation, the study of thymus organogenesis has made slower progress...
  89. pmc Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells
    Youngjo Kim
    Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, USA
    Science 334:1706-10. 2011
    ..However, B-type lamins are required for proper organogenesis. Defects in spindle orientation in neural progenitor cells and migration of neurons probably cause brain ..
  90. doi Pre-procambial cells are niches for pluripotent and totipotent stem-like cells for organogenesis and somatic embryogenesis in the peach palm: a histological study
    Marcílio de Almeida
    Departamento de Ciências Biológicas PPG em Fisiologia e Bioquímica de Plantas e PPG em Recursos Florestais, Escola Superior de Agricultura Luiz de Queiroz, Universidade de Sao Paulo, Piracicaba, São Paulo 13 418 900, Brazil
    Plant Cell Rep 31:1495-515. 2012
    ..PPCs provide niches for multipotent, pluripotent and totipotent stem-like cells for vascular differentiation, organogenesis and somatic embryogenesis in the peach palm...
  91. doi Genetic control of morphogenesis - Hox induced organogenesis of the posterior spiracles
    James Castelli Gair Hombría
    CABD, CSIC Universidad Pablo de Olavide, Sevilla, Spain
    Int J Dev Biol 53:1349-58. 2009
    ..We believe this may be a common characteristic for Hox induced organogenesis.
  92. pmc Gata6 is an important regulator of mouse pancreas development
    Kimberly Decker
    Program in Molecular Biology, Department of Biochemistry and Molecular Genetics, University of Colorado at Denver Health Sciences Center, Aurora, CO 80045, USA
    Dev Biol 298:415-29. 2006
    ..Conversely, the majority of transgenic Gata4-Engrailed embryos do not have a pancreatic phenotype. This study suggests that Gata6 is an important regulator of pancreas specification...
  93. pmc Genetic control of cell morphogenesis during Drosophila melanogaster cardiac tube formation
    Caroline Medioni
    Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique UMR 6216, Universite de la Mediterranee, 13288 Marseille, Cedex 9, France
    J Cell Biol 182:249-61. 2008
    ..We suggest that this new example of tube formation may be helpful in studying vertebrate heart tube formation and primary vasculogenesis...
  94. pmc Laminin α5 guides tissue patterning and organogenesis
    Caroline Spenlé
    INSERM U682, Universite de Strasbourg, Strasbourg, France
    Cell Adh Migr 7:90-100. 2013
    ..They participate in the modulation of epithelial/mesenchymal interactions and are implicated in organogenesis and maintenance of organ homeostasis...
  95. ncbi Growth patterns of human ovarian volume during intrauterine and postnatal organogenesis
    Chiarella Sforza
    Functional Anatomy Research Center FARC, Dipartimento di Morfologia Umana, Facoltà di Medicina e Chirurgia and Facoltà di Scienze Motorie, Universita degli Studi di Milano, Via Mangiagalli 31, I 20133 Milan, Italy
    Early Hum Dev 80:7-17. 2004
    ..In contrast, conclusive studies on normal human ovarian volume during intrauterine and postnatal organogenesis, when the folliculogenesis occurs, do not exist.
  96. doi Shotgun proteomic analysis on the embryos of silkworm Bombyx mori at the end of organogenesis
    Jian Ying Li
    College of Animal Sciences, Zhejiang University, Hangzhou 310029, PR China
    Insect Biochem Mol Biol 40:293-302. 2010
    ..mori embryos at the end of organogenesis (tubercle appearance stage, TA) was characterized using LTQ-Orbitrap mass spectrometer...
  97. doi Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma
    Yasuhiro Mouri
    Division of Molecular Immunology, Institute for Enzyme Research, The University of Tokushima, Tokushima 770 8503, Japan
    J Immunol 186:5047-57. 2011
    ..LTβR and RANK signals for optimal mTEC differentiation was underscored by the exaggerated defect of thymic organogenesis observed in mice doubly deficient for these signals...
  98. ncbi p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc
    Rebecca A Gladdy
    Program in Developmental Biology, Hospital for Sick Children Research Institute, Toronto Medical Discovery Tower Building East Tower, Room 14 312, 101 College Street, Toronto, Ontario, Canada M5G 1L7
    Mol Cancer Res 4:311-8. 2006
    ..Here, we show that ATM and Prkdc collaborate to maintain genomic stability during gastrulation and early organogenesis, a period of rapid proliferation and hypersensitivity to DNA damage. At E7.5 to E8...
  99. pmc Neuron navigator 3a regulates liver organogenesis during zebrafish embryogenesis
    Christian Klein
    Department of Angiogenesis and Cardiovascular Pathology, Max Delbrueck Center for Molecular Medicine MDC, Berlin, Germany
    Development 138:1935-45. 2011
    Endodermal organogenesis requires a precise orchestration of cell fate specification and cell movements, collectively coordinating organ size and shape...
  100. doi Fate maps of ventral and dorsal pancreatic progenitor cells in early somite stage mouse embryos
    Rika Miki
    Department of Stem Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Mech Dev 128:597-609. 2012
    ..Dorsal pancreatic progenitors originate from the dorsal endoderm at the 3-6 somite level at 7-9 ss, though they have not yet diverged from the dorsal gut progenitors at this stage...
  101. doi De novo shoot organogenesis: from art to science
    Jerome Duclercq
    Universite de Picardie Jules Verne, Unité de Recherche EA3900 Laboratoire Androgenèse et Biotechnologie, Faculte des Sciences, 33 rue Saint Leu, 80039 Amiens, France
    Trends Plant Sci 16:597-606. 2011
    In vitro shoot organogenesis and plant regeneration are crucial for both plant biotechnology and the fundamental study of plant biology...

Research Grants71

  1. Rac GTPase signaling during embryonic salivary gland branching morphogenesis
    Sharon Sequeira; Fiscal Year: 2012
    ..The knowledge gained from this project on the signaling mechanisms underlying early salivary gland organogenesis will be of considerable significance to the fields of tissue engineering and regenerative medicine and to ..
  2. Mouse models of genomic instability and birth defects
    CATHERINE ELIZABETH KEEGAN; Fiscal Year: 2013
    ..In Aim 2, the hypothesis that normal Acd function is critical during early organogenesis will be tested using an inducible targeted knockout of the Acd gene during development...
  3. Mechanisms of TGFB Signal Transduction
    Akiko Hata; Fiscal Year: 2013
    ..patterning, left-right asymmetry, neurogenesis, somite and skeletal development, limb patterning, and organogenesis. Germline mutations of the type II BMP receptor (BMPRII) genes are associated with IPAH...
  4. MECHANISMS OF FGF RECEPTOR REGULATION AND SIGNALING
    Moosa Mohammadi; Fiscal Year: 2013
    ..FGF7, FGF8, and FGF9 subfamilies play essential roles in spermatogenesis, mesoderm induction, somitogenesis, organogenesis, and pattern formation, whereas the FGF19 subfamily acts in an endocrine fashion to regulate major metabolic ..
  5. Genetic Control of Axial Patterning in Drosophila Eye
    Amit Singh; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): During organogenesis axial patterning is essential for growth and development...
  6. Molecular Analysis of GnRH Action
    Mark S Roberson; Fiscal Year: 2012
    ..developmental abnormalities associated with the loss of ERKs on cell lineage specification during pituitary organogenesis. We will directly examine the ability of GnRH to promote gene transcription in the absence of ERKs in vivo, ..
  7. A PANHYPOPITUITARY MOUSE MUTATION
    Sally A Camper; Fiscal Year: 2013
    ..goal is that a molecular understanding of this common birth defect will yield 1) fundamental information about organogenesis, 2) diagnoses with value for predicting risk and monitoring progression, and 3) provide insight about ..
  8. ANALYSIS OF CHROMATIN REMODELING IN MAMMARY GLAND DEVELOPMENT USING TILING ARRAYS
    Monique Rijnkels; Fiscal Year: 2009
    ..they will provide a foundation for understanding epigenetic changes that determine differentiation and organogenesis of specific tissues...
  9. Regulation of TGF-beta Signaling and Embryonic Development by GTPases
    Gerald H Thomsen; Fiscal Year: 2010
    ..The GTPBP genes are expressed during early Xenopus embryogenesis and during subsequent organogenesis of somites, blood, heart and nervous system...
  10. Cytotoxic-T-Lymphocyte (CTL) Therapy of AML
    Bruce R Blazar; Fiscal Year: 2013
    ..LN organogenesis is dependent upon lymphotoxin-[unreadable]1[unreadable]2, expressed on activated T-cells, B-cells and lymphoid ..
  11. Cell Specific Expression in the Pituitary Gland
    Sally A Camper; Fiscal Year: 2013
    ..of these transcription factors has advanced our understanding of the genetic hierarchy that controls pituitary organogenesis. To understand the mechanisms that underlie congenital pituitary hypoplasia, links need to be made between ..
  12. Plexin signalling in melanocyte biology and melanoma progression
    Glynis A Scott; Fiscal Year: 2013
    ..multiple biologic processes, including cell adhesion and migration, neurite extension, immune function, organogenesis, and tumor progression...
  13. Inducible Dysplastic Nephropathy in B2-Deficient Mice
    Samir S El-Dahr; Fiscal Year: 2013
    ..A physiological cross-talk operates between the tumor suppressor protein, p53, and the BdkrB2 during renal organogenesis. Thus, while BdkrB2 is a target for p53-mediated transcriptional activation, BdkrB2 is required to prevent the ..
  14. Molecular and Cellular Regulation of Mammalian Renal Medulla Development
    Jing Yu; Fiscal Year: 2013
    ..mechanisms required for renal medulla formation is important not only for the understanding of normal kidney organogenesis and physiology, but will also guide efforts in the development of new strategies of the repair and ..
  15. Small Molecule-Mediated Augmentation of Kidney Regeneration
    Neil A Hukriede; Fiscal Year: 2010
    ..hallmarks of renal tubular regeneration in AKI is the reactivation of embryonic genes normally required during organogenesis. We therefore hypothesized that any treatment that causes expansion of these progenitor cells during embryonic ..
  16. The Role of TAF4b in Spermatogonial Stem Cell Maintenance and Self-Renewal
    Eric Gustafson; Fiscal Year: 2013
    ..gene expression programs involved in diverse developmental events associated with multicellularity and organogenesis. The diversification of core transcription machinery is most notable in the germline where germ cell-specific ..
  17. Mechanism of CTIP2 action in mouse epidermal homeostasis and barrier formation,
    ARUP K INDRA; Fiscal Year: 2012
    ..it will, for the first time, reveal the cellular and molecular mechanisms by which CTIP2 regulates skin organogenesis, EPB formation, and tissue homeostasis...
  18. Analysis of the Role of Sprouty Genes in Tooth Development
    Ophir Klein; Fiscal Year: 2009
    ..our understanding of the molecular pathways that control epithelial-mesenchymal interactions during tooth organogenesis and may help lead to innovative treatments for patients with dental defects, including even the possibility of ..
  19. RENAL DISEASE
    MARC RANDALL HAMMERMAN; Fiscal Year: 2013
    ..core services to support a wide range of research endeavors including organ culture and transplantation (organogenesis);provides expertise and advice for investigators wishing to study diverse aspects of renal development, ..
  20. Molecular Mechanisms of Histone Acetyltransferases
    John M Denu; Fiscal Year: 2012
    ..into diverse cell types, how penetrance of disease is modulated by nutrition and environment, and how organogenesis, tissue formation, and aging occur...
  21. Retinal Cell-Fate Determination and Pattern Formation
    Graeme Mardon; Fiscal Year: 2012
    ..and So mediate the transition from determination to differentiation and thereby act at a critical junction in organogenesis. Our proposal focuses on understanding the role of these six genes in a well-characterized genetic system, the ..
  22. TOX, a Novel Regulator of Thymocyte Selection
    JONATHAN G KAYE; Fiscal Year: 2013
    ..that TOX plays roles outside the thymus, including an obligatory role in NK cell development and lymph node organogenesis. We propose here three specific aims to delineate the role and mechanism of action of TOX in development of ..
  23. Genetic and Transcriptional Control of Spleen Development
    Licia Selleri; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Organogenesis begins with the specification, positioning and assembly of the cell types specific to an organ into the organ primordium (anlage)...
  24. TERMINAL DIFFERENTIATION OF THE RENAL EPITHELIUM
    Samir S El-Dahr; Fiscal Year: 2012
    ..executes its differentiation functions are important basic steps toward understanding the genetic control of organogenesis. The proposed studies have important clinical implications as abnormal renal development is the leading cause ..
  25. Establishment of epithelial planar cell polarity
    Marek Mlodzik; Fiscal Year: 2013
    ..Both polarity and ordered patterning are established during organogenesis. Typical PCP examples include aspects of mammalian skin or internal organs, like the inner ear epithelium with ..
  26. Fetal Programming and Environmental Exposures: Implications for Prenatal Care and
    Jeffrey A Whitsett; Fiscal Year: 2012
    ..the trajectory of prenatal development and pre-term birth, including the effects on: implantation;placentation;organogenesis;and neonatal health, and how to combat these effects;(ii) foster and highlight the research contributions of ..
  27. Genesis of Epithelial Cell Lumens
    Jennifer L Harder; Fiscal Year: 2013
    ..She will also examine delivery of Crumbs3a and glycoproteins to the apical lumen surface during organogenesis of lumen-forming organs in mice using lectin immunohistochemistry and protein immuno-isolation techniques...
  28. The role of Sprouty genes in development of mammalian external genitalia
    Ophir D Klein; Fiscal Year: 2012
    ..In this application, we will investigate how Sprouty genes control organogenesis of the mammalian external genitalia...
  29. Role of Hypoxia in Differentiation
    Ernestina Schipani; Fiscal Year: 2012
    ..Thus, its relevance is high for both organogenesis and mesenchymal stem cell biology.
  30. Spatial Regulation of BMP Signaling in Dorsoventral Patterning
    David A Weisblat; Fiscal Year: 2013
    ..of TGF-beta signaling is active throughout vertebrate development, ranging from dorsoventral patterning and organogenesis to the induction of teeth and hair follicles...
  31. Vitamin A dependent events in urinary tract formation.
    Cathy Mendelsohn; Fiscal Year: 2009
    ..present in 5-7 million pregnant women worldwide, a condition that in animal models can result in sub-optimal organogenesis. Understanding the role of vitamin A during gestation is thus of great importance...
  32. A Novel Approach to Decoding Vertebrate Gene Regulation
    SAMANTHA JEAN RIESENFELD; Fiscal Year: 2013
    ..of the regulatory code is essential for determining the cell-type-specific regulatory circuits that govern organogenesis and contribute to disease...
  33. GENETIC ANALYSIS OF THE MECHANISMS THAT REGULATE TOOTH MORPHOGENESIS
    GAIL ROBERTA MARTIN; Fiscal Year: 2010
    ..enhance our understanding of the signaling pathways that control epithelial-mesenchymal interactions during organogenesis and will contribute to knowledge about the stem-cell niche in the adult mouse incisor...
  34. Lymphoid Tissue Inducer/NK22 Cells and Post-transplant Immune Recovery
    Michael R Verneris; Fiscal Year: 2013
    ..Lymphoid tissue inducer (LTi) cells are responsible for fetal LN organogenesis and a related cell type is found in adult human SLT. In mice, adult LTi cells mediate SLT repair...
  35. Molecular and Cellular Controls of Placental Metabolism
    Yoel Sadovsky; Fiscal Year: 2013
    ..Throughout pregnancy and until birth, the placenta is obligatory for embryonic organogenesis, fetal growth, immunological support, and maintenance of healthy maternal-fetal communication, while ..
  36. Signaling Crosstalk Controlled by a Mad Phosphoserine Code
    EDWARD V EIVERS; Fiscal Year: 2013
    ..cascades regulate a diverse range of cellular events such as stem cell maintenance, cell differentiation and organogenesis, while dysfunctional signaling of either pathway can result in human diseases such as cancer...
  37. LRH-1: Structure-based Approach to Drug Design for Gastrointestinal Tumors
    James Bayrer; Fiscal Year: 2013
    ..Understanding of LRH-1 function is fundamental to future research in organogenesis, tumorigenesis, and gastrointestinal homeostasis...
  38. SEARCH FOR THE MOLECULAR CAUSES OF DIABETIC EMBRYOPATHY
    Mary R Loeken; Fiscal Year: 2013
    ..The malformations occur very early during gestation, at the beginning of organogenesis. In an effort to understand the molecular mechanisms by which maternal diabetes disturbs embryonic development,..
  39. SOX9 in prostate cancer development and progression
    Xin Yuan; Fiscal Year: 2012
    ..prostate epithelial cells and in the basal cells of adult prostate, suggesting it is involved in prostate organogenesis and homeostasis...
  40. Molecular basis for age-related thymic involution and rejuvenation
    Dong Ming Su; Fiscal Year: 2013
    ..Foxn1 mutations have provided information on mechanisms by which Foxn1 regulates TEC function during thymic organogenesis in the embryos. However, the function of Foxn1 in the mature thymus and in natural thymic aging is unclear...
  41. Bmp-signaling in craniofacial development
    JAMES FRANCIS MARTIN; Fiscal Year: 2012
    ..This research program will directly investigate the function of Bmp4 and Bmp2 in craniofacial organogenesis using conditional gene inactivation studies...
  42. Methods Development for CVM Cell Migration Study in Drosophila
    ANGELIKE M STATHOPOULOS; Fiscal Year: 2013
    ..of the embryo to another, effectively controlling cell-cell interactions to drive cell differentiation and organogenesis. The shape of most complex organ systems arises from the directed migration of cohesive cell groups...
  43. Role of T-box Genes in Mouse Development
    Virginia E Papaioannou; Fiscal Year: 2013
    ..the T-box family of transcription factor genes and how they interact and impinge on signaling pathways during organogenesis. The work started with an exploration of the evolution of the gene family and the discovery of previously ..
  44. p53-Regulation in Liver Regeneration
    MICHELLE ANN BARTON; Fiscal Year: 2012
    Renewed organogenesis of the fully differentiated liver is stimulated in response to surgical removal (partial hepatectomy, PHx) or destruction of liver tissue by chemicals or disease...
  45. The Effects of Ethanol on Amniotic Fluid-derived Stem Cells
    JENNIFER HIPP; Fiscal Year: 2010
    ..Stem cells maybe used as a tool elucidate mechanisms of ethanol's effect on organogenesis. For the current proposal, we plan to use a particular type of stem cells, amniotic fluid-derived stem cells (..
  46. Role of FGF10 in liver organogenesis and alcohol-impaired regeneration
    KASPER SAONUN WANG; Fiscal Year: 2010
    ..We postulate that the mechanism by which alcohol impairs liver regeneration may be due to impaired signaling through the FGF10/FGFR2b pathway we show normally promotes liver regeneration. ..
  47. Biochemical and Functional Studies of Sall1 in Kidney Development and TBS
    MICHAEL I RAUCHMAN; Fiscal Year: 2010
    b>Organogenesis requires the precise temporal and spatial control of gene expression to direct developmental programs that regulate a variety of cellular processes...
  48. Iron Delivery in the Developing Kidney
    Jonathan M Barasch; Fiscal Year: 2013
    ..The developing kidney requires sufficient iron for optimal organogenesis during pregnancy and in the early postnatal period...
  49. 6th International Conference on SBDS
    Sridhar Mani; Fiscal Year: 2011
    ..SDS, including genetic testing;and (ii) the molecular function of SBDS in hematopoiesis, leukemogenesis, and organogenesis. The meeting focus is significant from both clinical and scientific perspectives and will hopefully help ..
  50. Role of microRNAs in mammalian ear development and neurosensory specification
    GARRETT ANDREW SOUKUP; Fiscal Year: 2013
    ..proliferation, differentiation and fate specification that ultimately affect morphogenesis, histogenesis and organogenesis in a variety of organisms...
  51. Molecular Patterning of Mammalian Dentition
    Rulang Jiang; Fiscal Year: 2013
    ..development has long been used as a powerful model system for studying the molecular mechanisms regulating organogenesis and the pathogenic mechanisms of tooth developmental anomalies in humans...
  52. Function and regulation of T-box factors in C. elegans
    Peter G Okkema; Fiscal Year: 2010
    ..term goal is to understand the development of the pharynx as a simple model for cell-type specification and organogenesis. The primary focus of this application is on the mechanisms regulating expression and function of the T-box ..
  53. Standardized Next Generation Transcriptome Profiling Tools for X. Tropicalis
    Zhihua Jiang; Fiscal Year: 2013
    ..provide new insights into mechanisms in cell cycle and mitosis, nuclear reprogramming and stem cell biology, organogenesis and tissue remodeling during metamorphosis and regeneration, and thus, deliver an essential model for the ..
  54. Investigation of Gene Regulation by NF-kappaB Transcription factors
    Gourisankar Ghosh; Fiscal Year: 2012
    ..been reported to associate with Bcl3 to activate transcription, and as such they play critical roles in immune organogenesis and tolerance...
  55. Mechanisms of Pbx-directed Genetic &Transcriptional Control of Limb Development
    Licia Selleri; Fiscal Year: 2013
    ..Despite their paramount roles in organogenesis and patterning of the body and limb axes, the molecular mechanisms of Hox regulation remain elusive...
  56. Spatial Segregation of Cell Functioning during Cell Motility
    Alan Wells; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Induced cell motility functions during organogenesis and wound repair to (re)populate the target space, a situation that is deficient in a number of clinical conditions and in aging individuals...
  57. Genomic survey of cis-regulatory element function by high-throughput transgenesis
    Robert M Grainger; Fiscal Year: 2012
    ..hypothesis underlying this proposal is that many developmental processes, including embryonic patterning and organogenesis, are highly conserved among vertebrates, and that the genetic machinery regulating these processes is also ..
  58. The role of DNA methylation in lens fiber cell terminal differentiation
    Rachel K Tittle; Fiscal Year: 2012
    ..However, the specific role of DNA methylation in terminal differentiation and organogenesis has so far been studied in very few cell types...
  59. Innovative In Vivo-like Model for Vascular Tissue Engineering
    Eva Schmelzer; Fiscal Year: 2013
    ..model systems, by analyzing neo-vascularization in an organ-like environment in vitro designed to mimic human organogenesis and that can vary physical conditions, such as flow- and pressure changes in the rhythm of the heart rate...
  60. Functional and Evolutionary Genomics of Ancient Small RNAs
    Michael J Axtell; Fiscal Year: 2012
    ..The regulation of specific "target" genes by microRNAs is critical for embryonic development, organogenesis, and stress responses...
  61. Branching Morphogenesis of Urinary Epithelia: from Genes to Cellular Behaviors
    FRANKLIN D COSTANTINI; Fiscal Year: 2013
    ..make a functional ureter, while complex patterns of UB branching morphogenesis are required for normal renal organogenesis. While many genes involved in these events have been identified, the genetic instructions must be translated ..
  62. The Structural Basis of Shroom-Mediated Cell Contractility
    ANDREW PAUL VANDEMARK; Fiscal Year: 2013
    ..The regulation of cell architecture and morphology is essential during the course of vertebrate development, organogenesis, and tissue homeostasis...
  63. PREVENTION OF X-RAY INDUCED MALFORMATIONS
    MARVIN SODICOFF; Fiscal Year: 1990
    ..The rat is most susceptible to x-ray teratogenesis during the period of early organogenesis. Defects typically affect the head resulting in craniofacial abnormalities e.g...
  64. ENDOSTATIN RECEPTOR CDNA CLONING AND IONIC SIGNALING
    Seth Alper; Fiscal Year: 2001
    ..Angiogenesis is now recognized as a process central to embryonic development, organogenesis and regenerative tissues proliferation, and tumor growth...
  65. Fourth Symposium Biology Vertebrate Sex Determination
    Blanche Capel; Fiscal Year: 2006
    ..Surprisingly, the mechanisms of testis and ovary organogenesis are proving to be highly diverged and providing exciting insights into the evolution of developmental ..
  66. NR4A Regulation of Organ Morphogenesis
    CHRISTOPHER GISSENDANNER; Fiscal Year: 2009
    ..Thus, NHR-6 appears to function as a critical, dualistic transcriptional regulator of organogenesis in C. elegans...
  67. ARTHRITIS AND MUSCULOSKELETAL DISEASES CENTER
    David Fox; Fiscal Year: 2001
    ..and Aging, 4) Development and Application of Imaging Techniques, 5) Orthopedics and Biomechanics, and 6) Organogenesis. In support of these major programs, funding is requested for none core facilities: 1) Flow Cytometry Core, 2) ..
  68. SIGNALS FOR RENAL ENDOTHELIAL CAPILLARY MORPHOGENESIS
    Jin Chen; Fiscal Year: 2001
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