fetal development

Summary

Summary: Morphological and physiological development of FETUSES.

Top Publications

  1. pmc Effect of in utero and early-life conditions on adult health and disease
    Peter D Gluckman
    Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Auckland, New Zealand
    N Engl J Med 359:61-73. 2008
  2. ncbi The origins of the developmental origins theory
    D J P Barker
    DOHaD Division, University of Southampton, UK
    J Intern Med 261:412-7. 2007
  3. pmc Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates
    Carrie E McCurdy
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Clin Invest 119:323-35. 2009
  4. pmc Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring
    Karen A Lillycrop
    Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 100:278-82. 2008
  5. ncbi Placental mTOR links maternal nutrient availability to fetal growth
    Sara Roos
    Perinatal Center, Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, P O Box 432, SE 405 30 Gothenburg, Sweden
    Biochem Soc Trans 37:295-8. 2009
  6. pmc Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus
    Ute M Schaefer-Graf
    Department of Obstetrics, Vivantes Medical Center Berlin Neukoelln, Berlin, Germany
    Diabetes Care 31:1858-63. 2008
  7. pmc Generation of naive-like porcine-induced pluripotent stem cells capable of contributing to embryonic and fetal development
    Shuh Hei Fujishiro
    Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
    Stem Cells Dev 22:473-82. 2013
  8. ncbi The developmental origins of adult disease
    D J P Barker
    University of Southampton, MRC Epidemiology Centre, Southampton General Hospital, Southampton, SO16 6YD, England
    J Am Coll Nutr 23:588S-595S. 2004
  9. ncbi The short- and long-term implications of maternal obesity on the mother and her offspring
    P M Catalano
    Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH 44109, USA
    BJOG 113:1126-33. 2006
  10. ncbi Programming of body composition by early growth and nutrition
    Jonathan C K Wells
    Childhood Nutrition Research Centre, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Proc Nutr Soc 66:423-34. 2007

Detail Information

Publications374 found, 100 shown here

  1. pmc Effect of in utero and early-life conditions on adult health and disease
    Peter D Gluckman
    Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Auckland, New Zealand
    N Engl J Med 359:61-73. 2008
  2. ncbi The origins of the developmental origins theory
    D J P Barker
    DOHaD Division, University of Southampton, UK
    J Intern Med 261:412-7. 2007
    ..The association between low birthweight and coronary heart disease has been confirmed in longitudinal studies of men and women around the world. The developmental model of the origins of the disease offers a new way forward...
  3. pmc Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates
    Carrie E McCurdy
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Clin Invest 119:323-35. 2009
    ..juvenile obesity and metabolic diseases; however, the mechanism(s) whereby excess maternal nutrition affects fetal development remain poorly understood...
  4. pmc Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring
    Karen A Lillycrop
    Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 100:278-82. 2008
    ..These data show for the first time that prenatal nutrition induces differential changes to the methylation of individual CpG dinucleotides in juvenile rats which persist in adults...
  5. ncbi Placental mTOR links maternal nutrient availability to fetal growth
    Sara Roos
    Perinatal Center, Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, P O Box 432, SE 405 30 Gothenburg, Sweden
    Biochem Soc Trans 37:295-8. 2009
    ..Since fetal growth is critically dependent on placental nutrient transport, placental mTOR signalling plays an important role in the regulation of fetal growth...
  6. pmc Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus
    Ute M Schaefer-Graf
    Department of Obstetrics, Vivantes Medical Center Berlin Neukoelln, Berlin, Germany
    Diabetes Care 31:1858-63. 2008
    ..To determine the contribution of maternal glucose and lipids to intrauterine metabolic environment and fetal growth in pregnancies with gestational diabetes mellitus (GDM)...
  7. pmc Generation of naive-like porcine-induced pluripotent stem cells capable of contributing to embryonic and fetal development
    Shuh Hei Fujishiro
    Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
    Stem Cells Dev 22:473-82. 2013
    ..8%) as assessed by fluorescent markers. They also contributed to the in utero fetal development (11/71, 15.5% at day 23; 1/13, 7.7% at day 65)...
  8. ncbi The developmental origins of adult disease
    D J P Barker
    University of Southampton, MRC Epidemiology Centre, Southampton General Hospital, Southampton, SO16 6YD, England
    J Am Coll Nutr 23:588S-595S. 2004
    ..A new vision of optimal early human development is emerging which takes account of both short and long-term outcomes...
  9. ncbi The short- and long-term implications of maternal obesity on the mother and her offspring
    P M Catalano
    Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH 44109, USA
    BJOG 113:1126-33. 2006
    ..Additionally, we will review evidence of both short- and long-term effect of maternal obesity on the in utero environment as it relates to fetal growth, neonatal body composition and adolescent obesity...
  10. ncbi Programming of body composition by early growth and nutrition
    Jonathan C K Wells
    Childhood Nutrition Research Centre, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Proc Nutr Soc 66:423-34. 2007
    ....
  11. pmc The Generation R Study Biobank: a resource for epidemiological studies in children and their parents
    Vincent W V Jaddoe
    The Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 22:917-23. 2007
    ....
  12. pmc Oxygen, the Janus gas; its effects on human placental development and function
    Graham J Burton
    Centre for Trophoblast Research, Department of Physiology Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
    J Anat 215:27-35. 2009
    ..Establishing an inviolable maternal blood supply for the second and third trimesters is therefore one of the most crucial aspects of human placentation...
  13. ncbi Early fetal development of the human cerebellum
    Kwang Ho Cho
    Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science, 344 2 Sinyong dong, Iksan, Jeonbuk, Korea
    Surg Radiol Anat 33:523-30. 2011
    ..Consequently, in the early stages, it appears that the cerebellar hemisphere and vermis develop independently of each other...
  14. ncbi Maternal cholesterol in fetal development: transport of cholesterol from the maternal to the fetal circulation
    Laura A Woollett
    Department of Pathology, 2120 East Galbraith Road, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45236 0507, USA
    Am J Clin Nutr 82:1155-61. 2005
    Cholesterol is required for fetal development. Data obtained from recent studies in humans, rodents, and cell cultures showed that circulating maternal cholesterol can affect fetal metabolism and sterol accretion...
  15. pmc Early influences on cardiovascular and renal development
    J J Miranda Geelhoed
    Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 25:677-92. 2010
    ..This review is focused on specific adverse fetal exposures, cardiovascular adaptations and perspectives for new studies...
  16. pmc Dietary intervention prior to pregnancy reverses metabolic programming in male offspring of obese rats
    E Zambrano
    Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
    J Physiol 588:1791-9. 2010
    ..We believe this is the first study showing reversibility of adverse metabolic effects of maternal obesity on offspring metabolic phenotype, and that outcomes and reversibility vary by tissue affected...
  17. ncbi Intrauterine programming of physiological systems: causes and consequences
    Abigail L Fowden
    Department of Physiology, University of Cambridge, Cambridge, UK
    Physiology (Bethesda) 21:29-37. 2006
    ..Intrauterine programming of physiological systems occurs at the gene, cell, tissue, organ, and system levels and causes permanent structural and functional changes, which can lead to overt disease, particularly with increasing age...
  18. ncbi The role of the insulin-like growth factor system in prenatal growth
    Ruvdeep Randhawa
    Division of Endocrinology, Department of Pediatrics, Mattel Children s Hospital at UCLA, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Mol Genet Metab 86:84-90. 2005
    ....
  19. pmc Multiple micronutrient supplementation during pregnancy in low-income countries: a meta-analysis of effects on birth size and length of gestation
    Caroline H D Fall
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK
    Food Nutr Bull 30:S533-46. 2009
    ..Multiple micronutrient deficiencies are common among women in low-income countries and may adversely affect pregnancy outcomes...
  20. ncbi Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus
    Vanessa E Murphy
    Mothers and Babies Research Centre, and Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, University of Newcastle, New South Wales, Australia
    Endocr Rev 27:141-69. 2006
    ..Endocrine regulation of fetal growth involves interactions between the mother, placenta, and fetus, and these effects may program long-term physiology...
  21. ncbi B12 in fetal development
    M Reese Pepper
    University of Maryland School of Medicine, Department of Pediatrics, Division of Growth and Nutrition, Baltimore, MD 21201, USA
    Semin Cell Dev Biol 22:619-23. 2011
    ..Further studies in this area to elucidate the pathways of cobalamin influence on development, as well as to prevent B12 deficiency in pregnant women and children are indicated...
  22. ncbi Contribution of the anterior longitudinal ligament to ossification and growth of the vertebral body: an immunohistochemical study using the human fetal lumbar vertebrae
    Zhe Wu Jin
    Department of Surgery, Research Institute of Clinical Medicine, Chonbuk National University Hospital, 634 18 Keumam dong, Dukjin Gu, Jeonju, Jeonbuk 561 712, Korea
    Surg Radiol Anat 33:11-8. 2011
    ....
  23. pmc Maternal personal exposure to airborne benzene and intrauterine growth
    Remy Slama
    INSERM, Institut National de la Sante et de la Recherche Medicale, University J Fourier Grenoble, Avenir Team Environmental Epidemiology Applied to Fecundity and Reproduction, U823, Institut Albert Bonniot, Grenoble, France
    Environ Health Perspect 117:1313-21. 2009
    ..Studies relying on outdoor pollutants measures have reported associations between air pollutants and birth weight...
  24. pmc Placental adaptive responses and fetal programming
    Leslie Myatt
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, PO Box 670526, Cincinnati, OH 45267, USA
    J Physiol 572:25-30. 2006
    Fetal programming occurs when the normal pattern of fetal development is disrupted by an abnormal stimulus or 'insult' applied at a critical point in in utero development...
  25. ncbi Developmental plasticity and developmental origins of non-communicable disease: theoretical considerations and epigenetic mechanisms
    Mark Hanson
    DOHaD Centre, University of Southampton, Southampton SO166YD, United Kingdom
    Prog Biophys Mol Biol 106:272-80. 2011
    ..Elucidation of epigenetic processes may permit perinatal identification of individuals most at risk of later NCD and enable early intervention strategies to reduce such risk...
  26. pmc Maternal zinc supplementation and growth in Peruvian infants
    Lora L Iannotti
    International Food Policy Research Institute and the George Washington University School of Public Health and Health Services, Washington, DC, USA
    Am J Clin Nutr 88:154-60. 2008
    ..Little is known about how maternal zinc intake influences growth in utero and in postnatal life in humans...
  27. ncbi Developmental origins of adult health and disease: the role of periconceptional and foetal nutrition
    I Caroline McMillen
    Early Origins of Adult Health Research Group, Sansom Research Institute, School of Pharmacy and Medical Science, University of South Australia, Adelaide, SA, Australia
    Basic Clin Pharmacol Toxicol 102:82-9. 2008
    ..In this context, the physiological responses to relative overnutrition in early life may directly contribute to an intergenerational cycle of obesity...
  28. ncbi Developmental and epigenetic pathways to obesity: an evolutionary-developmental perspective
    P D Gluckman
    Liggins Institute, The University of Auckland, Auckland, New Zealand
    Int J Obes (Lond) 32:S62-71. 2008
    ..Secondly, maternal diabetes, maternal obesity and infant overfeeding are associated with a greater risk of later obesity. Early life offers a potential point for preventative intervention...
  29. ncbi Associations between fetal size, maternal {alpha}-tocopherol and childhood asthma
    Stephen W Turner
    Department of Child Health, University of Aberdeen, Royal Aberdeen Children s Hospital, Foresterhill, Aberdeen AB25 2ZG, UK
    Thorax 65:391-7. 2010
    ..002). CONCLUSIONS These findings support the concept of very early fetal programming of respiratory disease. Maternal vitamin E status may be one determinant for growth of the fetus and fetal lungs during early pregnancy...
  30. pmc Programming placental nutrient transport capacity
    A L Fowden
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    J Physiol 572:5-15. 2006
    ....
  31. ncbi Risk factors and outcomes associated with first-trimester fetal growth restriction
    Dennis O Mook-Kanamori
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    JAMA 303:527-34. 2010
    ..Adverse environmental exposures lead to developmental adaptations in fetal life. The influences of maternal physical characteristics and lifestyle habits on first-trimester fetal adaptations and the postnatal consequences are not known...
  32. pmc Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth
    Noriaki Washino
    Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Environ Health Perspect 117:660-7. 2009
    ..Although recent studies have shown that these chemicals interfere with fetal growth in humans, the results are inconsistent...
  33. ncbi Fetal programming: link between early nutrition, DNA methylation, and complex diseases
    Agata Chmurzynska
    Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, Wojska Polskiego 31, Poznan, Poland
    Nutr Rev 68:87-98. 2010
    ....
  34. pmc Associations of gestational weight gain with short- and longer-term maternal and child health outcomes
    Emily Oken
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
    Am J Epidemiol 170:173-80. 2009
    ..For obese women, the lowest-risk weight change was weight loss in all models. Recommendations for gestational weight gain for obese women should be revised...
  35. ncbi Maternal smoking and fetal growth characteristics in different periods of pregnancy: the generation R study
    Vincent W V Jaddoe
    The Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Epidemiol 165:1207-15. 2007
    ..The larger effect on femur length suggests that smoking during pregnancy affects primarily peripheral tissues...
  36. ncbi Developmental programming of obesity in mammals
    P D Taylor
    Division of Reproduction and Endocrinology, 10 Floor North Wing, St Thomas Hospital, London SE1 7EH, UK
    Exp Physiol 92:287-98. 2007
    ....
  37. ncbi Intrauterine exposure to mild analgesics during pregnancy and the occurrence of cryptorchidism and hypospadia in the offspring: the Generation R Study
    Claudia A Snijder
    The Generation R Study Group, Erasmus University Medical Centre, Dr Molewaterplein 50 60, 3015 GE Rotterdam, The Netherlands
    Hum Reprod 27:1191-201. 2012
    ..We examined the influence of maternal exposure to mild analgesics during pregnancy on the occurrence of cryptorchidism and hypospadia in their offspring...
  38. ncbi Nutritional programming of gastrointestinal tract development. Is the pig a good model for man?
    Paul Guilloteau
    INRA, U1079, Unite Mixte de Recherche Systeme Elevage, Nutrition Animale et Humaine UMR SENAH, Saint Gilles, France
    Nutr Res Rev 23:4-22. 2010
    ..In particular, the 'sow-piglets' dyad could be a useful tool to simulate the 'human mother-infant' dyad in studies which examine short-, middle- and long-term effects and is suggested as the reference model...
  39. pmc The amniotic fluid transcriptome: a source of novel information about human fetal development
    Lisa Hui
    Mother Infant Research Institute and Division of Genetics, Department of Pediatrics, The Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts, USA
    Obstet Gynecol 119:111-8. 2012
    ..The objective of this study was to develop an understanding of the amniotic fluid core transcriptome by analyzing the transcripts ubiquitously present in the amniotic fluid supernatant of euploid midtrimester fetuses...
  40. ncbi Fetal macrosomia in pregnant women with gestational diabetes
    Jadranko Segregur
    Department of Gynecology and Obstetrics, General Hospital Virovitica, Virovitica, Croatia
    Coll Antropol 33:1121-7. 2009
    ....
  41. ncbi Role of the placenta in regulation of fetal iron status
    Harry J McArdle
    Rowett Institute of Nutrition and Health, University of Aberdeen, Greenburn Road, Bucksburn, Aberdeen, United Kingdom
    Nutr Rev 69:S17-22. 2011
    ..This review examines how the fetus, and not the mother, regulates iron uptake and transfer across the placenta, how these processes interact, and how the fetus can modulate iron metabolism in the mother...
  42. ncbi Asthma and pregnancy: emerging evidence of epigenetic interactions in utero
    Susan L Prescott
    University of Western Australia, Perth, Western Australia
    Curr Opin Allergy Clin Immunol 9:417-26. 2009
    ....
  43. ncbi Perfluoroalkyl chemicals and human fetal development: an epidemiologic review with clinical and toxicological perspectives
    Geary W Olsen
    Medical Department, 3M Company, St Paul, MN 55144, USA
    Reprod Toxicol 27:212-30. 2009
    ..epidemiologic literature as it pertains to the potential association of exposure to PFOS and PFOA with human fetal development. The published research has focused on birth weight and other measurements that reflect human fetal ..
  44. ncbi Changes in interleukin-6 and IGF system and their relationships in placenta and cord blood in newborns with fetal growth restriction compared with controls
    Maria E Street
    Department of Pediatrics, University of Parma, Italy
    Eur J Endocrinol 155:567-74. 2006
    ..It is unknown whether these occur in the placenta. The aim of this study was to assess whether interleukin-6 (IL-6) modulated the IGF system...
  45. ncbi Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches
    Thomas Jansson
    Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    Clin Sci (Lond) 113:1-13. 2007
    ....
  46. ncbi Biological mechanisms for nutritional regulation of maternal health and fetal development
    Guoyao Wu
    Faculty of Nutrition and Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
    Paediatr Perinat Epidemiol 26:4-26. 2012
    This review paper highlights mechanisms for nutritional regulation of maternal health and fetal development. Malnutrition (nutrient deficiencies or obesity) in pregnant women adversely affects their health by causing or exacerbating a ..
  47. ncbi New charts for ultrasound dating of pregnancy and assessment of fetal growth: longitudinal data from a population-based cohort study
    B O Verburg
    The Generation R Study Group, Erasmus Medical Center, Sophia Children s Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Ultrasound Obstet Gynecol 31:388-96. 2008
    ....
  48. pmc Adverse effects of trichothiodystrophy DNA repair and transcription gene disorder on human fetal development
    R Moslehi
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Clin Genet 77:365-73. 2010
    ..Thus, we hypothesize that TTD DNA repair and transcription genes play an important role in normal human placental development...
  49. pmc p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability
    Mikako Yagi
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Nucleic Acids Res 40:9717-37. 2012
    ..Co-immunoprecipitation revealed the close association of p32 with the mitoribosome. We propose that p32 is required for functional mitoribosome formation to synthesize proteins within mitochondria...
  50. ncbi Resistance exercise training during pregnancy and newborn's birth size: a randomised controlled trial
    R Barakat
    Facultad de Ciencias de la Actividad Física y del Deporte INEF, Universidad Politecnica de Madrid, Madrid, Spain
    Int J Obes (Lond) 33:1048-57. 2009
    ..We also studied the association between maternal body weight prior to pregnancy and newborn's birth size...
  51. ncbi Placental metabolic reprogramming: do changes in the mix of energy-generating substrates modulate fetal growth?
    Nicholas P Illsley
    Department of Obstetrics, Gynecology and Womens Health, UMDNJ New Jersey Medical School, Newark, NJ, USA
    Int J Dev Biol 54:409-19. 2010
    ....
  52. ncbi Small for gestational age: short stature and beyond
    Paul Saenger
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10467, USA
    Endocr Rev 28:219-51. 2007
    ..Recent data, however, suggest that long-term treatment with GH does not increase the risk of type 2 diabetes mellitus and the metabolic syndrome in young adults born SGA...
  53. pmc The transition from fetal growth restriction to accelerated postnatal growth: a potential role for insulin signalling in skeletal muscle
    B S Muhlhausler
    Early Origins of Adult Health Research Group, Sansom Research Institute, University of South Australia, Adelaide 5001, Australia
    J Physiol 587:4199-211. 2009
    ..These data provide evidence that the origins of the accelerated growth experienced by the small baby after birth lie in the adaptive response of the growth restricted fetus to its low placental substrate supply...
  54. pmc Biomonitoring of bisphenol A concentrations in maternal and umbilical cord blood in regard to birth outcomes and adipokine expression: a birth cohort study in Taiwan
    Wei Chun Chou
    Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan
    Environ Health 10:94. 2011
    ....
  55. ncbi Exercise in pregnancy: weighing up the long-term impact on the next generation
    Sarah A Hopkins
    Liggins Institute, The University of Auckland, New Zealand
    Exerc Sport Sci Rev 39:120-7. 2011
    ..This review considers the evidence for both positive and negative long-term health outcomes for offspring...
  56. ncbi The role of iodine in human growth and development
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Semin Cell Dev Biol 22:645-52. 2011
    ..Iodine prophylaxis of deficient populations with periodic monitoring is an extremely cost effective approach to reduce the substantial adverse effects of iodine deficiency throughout the life cycle...
  57. ncbi Haem oxygenase-1 dictates intrauterine fetal survival in mice via carbon monoxide
    Maria Laura Zenclussen
    Department of Experimental Obstetrics and Gynecology, Medical Faculty, Otto von Guericke University, Gerhart Hauptmann Strasse 35, Magdeburg, Germany
    J Pathol 225:293-304. 2011
    ..associated with haem release from maternal or fetal haemoglobins, thus ensuring placental function and fetal development. We demonstrate that HO-1 expression is essential to promote placental function and fetal development, thus ..
  58. pmc Fetal programming of adipose tissue: effects of intrauterine growth restriction and maternal obesity/high-fat diet
    Mina Desai
    Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Semin Reprod Med 29:237-45. 2011
    ..Thus preventive therapeutic interventions will require target-specific modalities that depend on the primary etiology...
  59. ncbi Limited and excess protein intake of pregnant gilts differently affects body composition and cellularity of skeletal muscle and subcutaneous adipose tissue of newborn and weanling piglets
    Charlotte Rehfeldt
    Research Unit Muscle Biology and Growth, Leibniz Institute for Farm Animal Biology, Wilhelm Stahl Allee 2, Dummerstorf, Germany
    Eur J Nutr 51:151-65. 2012
    ....
  60. ncbi The effects of alcohol on fetal development
    Kenneth Lyons Jones
    Department of Pediatrics, Division of Dysmorphology Teratology, University of California, San Diego, 92093 0828, USA
    Birth Defects Res C Embryo Today 93:3-11. 2011
    Prenatal exposure to alcohol has profound effects on many aspects of fetal development. Although alterations of somatic growth and specific minor malformations of facial structure are most characteristic, the effects of alcohol on brain ..
  61. ncbi Placental restriction of fetal growth decreases IGF1 and leptin mRNA expression in the perirenal adipose tissue of late gestation fetal sheep
    Jaime A Duffield
    Discipline of Physiology, School of Molecular and Biomedical Sciences, The University of Adelaide, SA, Australia
    Am J Physiol Regul Integr Comp Physiol 294:R1413-9. 2008
    ....
  62. ncbi Impaired fetal growth decreases the risk of childhood atopic eczema: a Swedish twin study
    C Lundholm
    Department of Medical Epidemiology and Biostatistics, Karolinska University Hospital Solna, Stockholm, Sweden
    Clin Exp Allergy 40:1044-53. 2010
    ..Studies have found associations between birth weight and risk of atopic eczema or allergic rhinitis (AR), although this could be due to confounding...
  63. ncbi Mother's educational level and fetal growth: the genesis of health inequalities
    Lindsay M Silva
    The Generation R Study Group, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Int J Epidemiol 39:1250-61. 2010
    ....
  64. pmc Diet-induced obesity model: abnormal oocytes and persistent growth abnormalities in the offspring
    Emily S Jungheim
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Endocrinology 151:4039-46. 2010
    ....
  65. ncbi Partial contributions of developmental hypoxia and undernutrition to prenatal alterations in somatic growth and cardiovascular structure and function
    Emily J Camm
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, United Kingdom
    Am J Obstet Gynecol 203:495.e24-34. 2010
    ..The objective of the study was to compare and contrast the effects of developmental hypoxia vs undernutrition on fetal growth, cardiovascular morphology, and function...
  66. ncbi Influence of endurance exercise and diet on human placental development and fetal growth
    J F Clapp
    Department of Reproductive Biology, Department of Obstetrics and Gynecology, MetroHealth Medical Center Campus of Case Western Reserve University, Cleveland, OH 44109, USA
    Placenta 27:527-34. 2006
    ..Thus, it may be possible to improve pregnancy outcomes in both healthy, low-risk women and a variety of high-risk populaces by simply modifying maternal physical activity and dietary carbohydrate intake during pregnancy...
  67. ncbi Intrauterine growth restriction: new concepts in antenatal surveillance, diagnosis, and management
    Francesc Figueras
    Department of Maternal Fetal Medicine, University of Barcelona, Hospital Clinic, Barcelona, Spain
    Am J Obstet Gynecol 204:288-300. 2011
    ..Appropriate protocols based on available evidence as well as individualized clinical assessment are essential to ensure good management and timely delivery...
  68. ncbi Nutritional modulation of adolescent pregnancy outcome -- a review
    J M Wallace
    Development, Growth and Function Division, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, AB21 9SB, UK
    Placenta 27:S61-8. 2006
    ..Thus, while the underlying mechanisms differ, maternal intake at both ends of the nutritional spectrum is a powerful determinant of fetal growth in pregnant adolescents...
  69. ncbi IFPA 2005 Award in Placentology Lecture. Human placental transport in altered fetal growth: does the placenta function as a nutrient sensor? -- a review
    T Jansson
    Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, PO Box 670526, Cincinnati, OH 45267, USA
    Placenta 27:S91-7. 2006
    ..Preliminary evidence suggests that placental mammalian target of rapamycin, a protein kinase regulating protein translation and transcription in response to nutrient stimuli, may be involved in placental nutrient sensing...
  70. ncbi Effect of seasonal programming on fetal development and longevity: links with environmental temperature
    Andreas D Flouris
    The Institute of Human Performance and Rehabilitation, Centre for Research and Technology, Thessaly, Greece
    Am J Hum Biol 21:214-6. 2009
    This study examined the effect of birth season on fetal development and longevity using two independent databases of all Greek citizens that were born (total: 516,874) or died (total: 554,101) between 1999 and 2003...
  71. pmc Nutritional programming of disease: unravelling the mechanism
    Simon C Langley-Evans
    Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, UK
    J Anat 215:36-51. 2009
    ..Programming of fetal development is considered to be an important risk factor for non-communicable diseases of adulthood, including coronary ..
  72. pmc Maternal antioxidant supplementation prevents adiposity in the offspring of Western diet-fed rats
    Sarbattama Sen
    Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 59:3058-65. 2010
    ..The aims of this study were to test the hypothesis that maternal obesity increases oxidative stress during fetal development, and to determine whether administration of an antioxidant supplement to pregnant Western diet-fed rats ..
  73. pmc Patterns of fetal and infant growth are related to atopy and wheezing disorders at age 3 years
    Katharine C Pike
    Child Health, University of Southampton School of Medicine, Southampton, UK
    Thorax 65:1099-106. 2010
    ..Little is known about whether patterns of early growth are associated with altered respiratory and immune development. This study relates prenatal and infant growth patterns to wheeze and atopy at age 3 years...
  74. ncbi Maternal undernutrition influences placental-fetal development
    Louiza Belkacemi
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, and David Geffen School of Medicine at UCLA, Torrance, California 90502, USA
    Biol Reprod 83:325-31. 2010
    Maternal nutrition during pregnancy has a pivotal role in the regulation of placental-fetal development and thereby affects the lifelong health and productivity of offspring...
  75. pmc Higher fish consumption in pregnancy may confer protection against the harmful effect of prenatal exposure to fine particulate matter
    Wieslaw Jedrychowski
    Epidemiology and Preventive Medicine, College of Medicine, Jagiellonian University, Krakow, Poland
    Ann Nutr Metab 56:119-26. 2010
    ..The objective of this study was to assess a hypothesized beneficial effect of fish consumption during the last trimester of pregnancy on adverse birth outcomes resulting from prenatal exposure to fine air particulate matter...
  76. pmc An animal model of cigarette smoke-induced in utero growth retardation
    Emily R Esposito
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, ULSD, 501 South Preston Street, Suite 301, Louisville, KY 40292, USA
    Toxicology 246:193-202. 2008
    ..The data also identify a period of susceptibility to in utero cigarette smoke exposure-induced growth retardation and LBW during pre-/peri-implantation embryonic development...
  77. ncbi Forced catch-up growth after fetal protein restriction alters the adipose tissue gene expression program leading to obesity in adult mice
    V V Bol
    Laboratory of Cell Biology Institute of Life Science, Universite Catholique de Louvain, Place Croix du Sud 5, 1348 Louvain la Neuve, Belgium
    Am J Physiol Regul Integr Comp Physiol 297:R291-9. 2009
    ....
  78. ncbi Growth and neurodevelopmental outcome of children born to mothers with pregestational and gestational diabetes
    Asher Ornoy
    Laboratory of Teratology, Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, and Israeli Ministry of Health, Jerusalem, Israel
    Pediatr Endocrinol Rev 3:104-13. 2005
    ....
  79. ncbi Physical activity and pregnancy: cardiovascular adaptations, recommendations and pregnancy outcomes
    Katarina Melzer
    Institute of Movement Sciences and Sports Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Sports Med 40:493-507. 2010
    ..Further studies with larger sample sizes are required to confirm the association between physical activity and outcomes of labour and delivery...
  80. ncbi Placental hormones and the control of maternal metabolism and fetal growth
    Dorothee Newbern
    Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Opin Endocrinol Diabetes Obes 18:409-16. 2011
    ..To examine the roles of the placental and pituitary hormones in the control of maternal metabolism and fetal growth...
  81. ncbi Maternal exposure to perfluorinated acids and fetal growth
    Michele P Hamm
    Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
    J Expo Sci Environ Epidemiol 20:589-97. 2010
    ..These results suggest that maternal PFA exposure has no substantial effect on fetal weight and length of gestation at the concentrations observed in this population...
  82. ncbi The known and unknown of leptin in pregnancy
    Sylvie Hauguel-De Mouzon
    Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH 44109, USA
    Am J Obstet Gynecol 194:1537-45. 2006
    ..We aim to demonstrate that studies of leptin in pregnancy largely have contributed to insight into the mechanisms of leptin action, both as a hormone and as a cytokine...
  83. ncbi Developmental programming of renal glucocorticoid sensitivity and the renin-angiotensin system
    Caitlin S Wyrwoll
    School of Anatomy and Human Biology, University of Western Australia, Nedlands, Perth, Australia
    Hypertension 50:579-84. 2007
    ..Partial prevention of programmed changes in renal gene expression by postnatal dietary omega-3 fatty acids provides insight into how this intervention prevents hypertension induced by fetal glucocorticoid excess...
  84. ncbi Fetal origins of adult diabetes
    Christina Kanaka-Gantenbein
    Division of Endocrinology, Diabetes and Metabolism, First Department of Pediatrics, University of Athens, Agia Sophia Children s Hospital, Athens, Greece
    Ann N Y Acad Sci 1205:99-105. 2010
    ....
  85. ncbi Review: Sex and the human placenta: mediating differential strategies of fetal growth and survival
    V L Clifton
    Robinson Institute, Department of Paediatrics and Reproductive Health, Faculty of Health Sciences, Medical North, Level 6, Frome Road, University of Adelaide, Adelaide, SA 5005, Australia
    Placenta 31:S33-9. 2010
    ..This review will present evidence supporting this hypothesis and will argue that to ignore the sex of the placenta is no longer sound scientific practice...
  86. pmc Exposure to undernutrition in fetal life determines fat distribution, locomotor activity and food intake in ageing rats
    L Bellinger
    School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, UK
    Int J Obes (Lond) 30:729-38. 2006
    ..To assess the long-term impact of undernutrition during specific periods of fetal life, upon central adiposity, control of feeding behaviour and locomotor activity...
  87. ncbi Placental corticotropin-releasing hormone (CRH), spontaneous preterm birth, and fetal growth restriction: a prospective investigation
    Pathik D Wadhwa
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697 4260, USA
    Am J Obstet Gynecol 191:1063-9. 2004
    ..hormone (CRH) as one of the primary endocrine mediators of parturition and possibly also of fetal development. The aim of this study was (1) to prospectively assess the relationship of maternal plasma concentrations of ..
  88. ncbi Stanniocalcin (STC) in the endometrial glands of the ovine uterus: regulation by progesterone and placental hormones
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 74:913-22. 2006
    ..The data suggest that STC1 secreted by the endometrial glands is transported into the fetal circulation and allantoic fluid, where it is hypothesized to regulate growth and differentiation of the fetus and placenta, by placental areolae...
  89. ncbi Fetal programming of pulmonary vascular dysfunction in mice: role of epigenetic mechanisms
    Emrush Rexhaj
    Dept of Internal Medicine, BH 10 640, 1011 Lausanne CHUV, Switzerland
    Am J Physiol Heart Circ Physiol 301:H247-52. 2011
    ..A similar mechanism may be involved in the fetal programming of vascular dysfunction in humans...
  90. ncbi Effect of n-3 long-chain polyunsaturated fatty acid supplementation of women with low-risk pregnancies on pregnancy outcomes and growth measures at birth: a meta-analysis of randomized controlled trials
    Hania Szajewska
    Department of Paediatric Gastroenterology and Nutrition, The Medical University of Warsaw, Warsaw, Poland
    Am J Clin Nutr 83:1337-44. 2006
    ..It is hypothesized that the intake of long-chain polyunsaturated fatty acids (LC-PUFAs) throughout pregnancy is important to maternal health and fetal and infant development...
  91. pmc Optimal fetal growth for the Caucasian singleton and assessment of appropriateness of fetal growth: an analysis of a total population perinatal database
    Eve M Blair
    Centre for Child Health Research, The University of Western Australia, at the Telethon Institute for Child Health Research, P, O, Box 855, West Perth, WA, 6872, Australia
    BMC Pediatr 5:13. 2005
    ..Appropriateness of growth can then be inferred from the ratio of the value of the observed dimension to that of the optimal dimension...
  92. ncbi Fetal development of the hand, digits and digit ratio (2D:4D)
    Mehmet Ali Malas
    Medical Faculty, Department of Anatomy, Suleyman Demirel University, 32260 Isparta, Turkey
    Early Hum Dev 82:469-75. 2006
    ..The purpose of this study was to investigate growth patterns in human hands, digits and digit ratio (2D:4D) during the fetal period...
  93. ncbi Maternal caffeine intake from coffee and tea, fetal growth, and the risks of adverse birth outcomes: the Generation R Study
    Rachel Bakker
    Departments of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands
    Am J Clin Nutr 91:1691-8. 2010
    ..Caffeine is a widely used and accepted pharmacologically active substance. The effect of caffeine intake during pregnancy on fetal growth and development is still unclear...
  94. pmc Continuous growth reference from 24th week of gestation to 24 months by gender
    Aimon Niklasson
    Göteborg Pediatric Growth Research Centre, Department of Pediatrics, the Institute for Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    BMC Pediatr 8:8. 2008
    ..An updated, continuous growth standard that bridges size at birth values with postnatal growth values can improve child growth screening and monitoring...
  95. ncbi Gestational weight gain in obese mothers and associations with fetal growth
    Stefanie N Hinkle
    Emory University, Atlanta, GA, USA
    Am J Clin Nutr 92:644-51. 2010
    ..In 2009, the Institute of Medicine recommended gestational weight gains (GWGs) of 5-9 kg for all obese women. Recommendations by severity of obesity were not specified because of a lack of available data...
  96. pmc Choline: critical role during fetal development and dietary requirements in adults
    Steven H Zeisel
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    Annu Rev Nutr 26:229-50. 2006
    ..Choline is critical during fetal development, when it influences stem cell proliferation and apoptosis, thereby altering brain and spinal cord structure ..
  97. ncbi Psychoneuroendocrine processes in human pregnancy influence fetal development and health
    Pathik D Wadhwa
    Behavioral Perinatology Research Program, Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, 92697 4260, USA
    Psychoneuroendocrinology 30:724-43. 2005
    ..A description of this body of work is followed by the elucidation of questions for further research and a discussion of implications for life-span development and health...
  98. doi Predictive adaptive responses in perspective
    Peter D Gluckman
    Trends Endocrinol Metab 19:109-10; author reply 112. 2008
  99. ncbi Developmental origins of disease paradigm: a mechanistic and evolutionary perspective
    Peter D Gluckman
    Liggins Institute, University of Auckland and National Research Centre for Growth and Development, Private Bag 92019, Auckland, New Zealand
    Pediatr Res 56:311-7. 2004
    ..The developmental origins paradigm and its underlying mechanistic and evolutionary basis have major implications for addressing the increasing burden of metabolic and cardiovascular disease...
  100. pmc Developmental programming of health and disease
    Simon C Langley-Evans
    School of Bioscience, University of Nottingham, Loughborough, UK
    Proc Nutr Soc 65:97-105. 2006
    ..Epigenetic mechanisms, including DNA methylation, may also be important processes in early-life programming...
  101. ncbi Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure
    Wade V Welshons
    Department of Biomedical Sciences, E102 Veterinary Medicine, University of Missouri Columbia, Columbia, Missouri 65211 5120, USA
    Endocrinology 147:S56-69. 2006
    ....

Research Grants73

  1. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2012
    ....
  2. Predictors of Pregnancy Outcome in SLE and APS
    Jane E Salmon; Fiscal Year: 2012
    ....
  3. Complement Activation in Pregnancy and Hypertension
    Jean F Regal; Fiscal Year: 2013
    ....
  4. Maternal One Carbon Metabolism and Low Birth Weight Infant
    Satish C Kalhan; Fiscal Year: 2013
    ..There are major public health and economic implications for this study, when one considers the enormous magnitude of the LBW, the associated clinical problems and the economic burden to the society. ..
  5. The Impact of Sleep-Disordered Breathing on Adverse Pregnancy Outcomes
    LOUISE M O apos BRIEN; Fiscal Year: 2010
    ..This study will ultimately lead to the development of early intervention strategies to treat sleep disordered breathing during pregnancy which may ultimately reduce risk of adverse pregnancy outcome. ..
  6. Predictors of Dietary Quality in Low-Income Pregnant Women
    Eileen R Fowles; Fiscal Year: 2010
    ..can alter the intrauterine nutritional environment and adversely affect placental development and subsequent fetal development and growth...
  7. Maternal Obesity affects AMP-Kinase in Muscle Cell Differentiation
    Min Du; Fiscal Year: 2013
    ..applicant): SIGNIFICANCE: 18-35% of pregnant American women are clinically obese, a condition which affects fetal development with long-term consequences for offspring health, including pre-disposition to obesity and type 2 diabetes (..
  8. Genome-wide DNA Methylation Profiles Associated with Abnormal Intrauterine Growth
    Cristina Montagna; Fiscal Year: 2013
    ..We offer a novel hypothesis that conditions during fetal development alter epigenetic patterns of DNA methylation in non-embryonic stem cells, which may be a marker for, or ..
  9. Climate Change and Adverse Birth Outcomes: Assessing the Vulnerability of Pregnan
    Shao Lin; Fiscal Year: 2013
    ..The multidisciplinary research team has a unique opportunity to use the data already collected and geo-coded through the NBDPS and other ongoing projects, which ensures the project is feasible and sustainable. ..
  10. Role of Physico-chemical Properties in the Reprotoxicity of Inhaled Cd NP.
    JUDITH TERRY ZELIKOFF; Fiscal Year: 2010
    ....
  11. Maternal Obesity and Gestational Diabetes: Impact on Metabolome
    William L Lowe; Fiscal Year: 2013
    ..Together, these studies will have an important impact on our understanding of the metabolic underpinnings of the increased risk of metabolic diseases in newborns of mothers with hyperglycemia and/or obesity. ..
  12. Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in Depression
    Jill M Goldstein; Fiscal Year: 2011
    ..We hypothesize that sex differences in MOD are initiated during fetal development, during hypothalamic-pituitary-adrenal (HPA) circuitry development and the sexual differentiation of the ..
  13. Functional Analysis of the Embryonic Epigenome in a Non-rodent Model
    Mark E Westhusin; Fiscal Year: 2013
    ..during bovine preimplantation development, then determine the effect on epigenetic reprogramming and embryo/fetal development. For study 1, RNA interference (RNAi) will be used transiently "knock down" expression of DNMTs and HMTs at ..
  14. DHA, Inflammation, and Insulin Sensitivity in Obese Pregnant Women
    Debra Krummel; Fiscal Year: 2009
    ....
  15. NICHD Maternal Fetal Medicine Units Network
    Geeta K Swamy; Fiscal Year: 2013
    ....
  16. Interaction of fetal growth and bisphenol A in obesity
    Frederick S vom Saal; Fiscal Year: 2013
    ..Perinatal exposure to BPA is predicted to interact synergistically with IUGR via additional epigenetic changes in adipocytes that alter the expression of estrogen-responsive genes and further accelerate postnatal growth. ..
  17. Human Decidual Leukocytes and Their Placental Ligands
    JACK STROMINGER; Fiscal Year: 2009
    ..abstract_text> ..
  18. Maternal Hyperinsulinemia and Fetal Programming
    Mulchand S Patel; Fiscal Year: 2011
    ..b>Fetal development in the 1-HC female rats results in spontaneous transfer of the HC phenotype to the offspring (2-HC rats) (..
  19. Feto-maternal DNA/RNA Trafficking: Biology and Application
    Diana W Bianchi; Fiscal Year: 2013
    ..In aim 3 we will determine whether one can use genomic approaches to better understand fetal development. Using existing software packages we will analyze the lists of differentially-regulated genes acquired in ..
  20. The Toxic Environment and the Epigenetics of Fetal Growth
    HEATHER HERSON BURRIS; Fiscal Year: 2013
    ....
  21. Development of a mouse model of obesity in pregnancy
    Thomas Jansson; Fiscal Year: 2009
    ....
  22. Genomic actions of progesterone receptors in human myometrial cells
    Sam Mesiano; Fiscal Year: 2010
    ..Clearly, the final phase of fetal development is best achieved in the womb environment rather than in the neonatal intensive care unit...
  23. Adipocyte Renin-Angiotensin System and Programming of Hypertension
    Mina Desai; Fiscal Year: 2010
    ..Our proposed studies will therefore determine the role of adipose renin-angiotensin system in development of adult hypertension and obesity in growth restricted newborns. ..
  24. Maternal Dietary Patterns and Child Weight Status
    Chantel L Martin; Fiscal Year: 2013
    ..Research studies suggest that the origins of obesity may be as early as during fetal development and maternal nutrition during pregnancy may play a role in programming the fetus for later development of ..
  25. GWA Mapping: Maternal Metabolism-Birth Weight Interactions
    WILLIAM LOWE; Fiscal Year: 2009
    ..A replication study will be performed in additional infants and mothers of European descent with follow-up studies also planned in Afro-Caribbeans, Hispanics of Mexican descent and Thais. ..
  26. Using a MALDI-TOF System for SNP Analysis
    Nadereh Jafari; Fiscal Year: 2010
    ....
  27. ALCOHOL AND HYPERPROLACTINEMIA
    DIPAK KUMAR SARKAR; Fiscal Year: 2013
    ..Therefore, the reports that rats exposed to alcohol during fetal development have increased susceptibility to hormonally induced pituitary tumors in adulthood suggest that offspring ..
  28. The Effects of Ethanol on Microtubules during Mouse Pre-implantation Development
    Yixian Zheng; Fiscal Year: 2012
    ....
  29. Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth
    MICHELLE WILHELM TURNER; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Perturbations of fetal development put children at risk for mortality and morbidity in early life...
  30. Effects of Maternal Influenza Immunization: A Field Trial in Guatemala'
    Saad B Omer; Fiscal Year: 2010
    ..Therefore, we propose to conduct a randomized, double-blind, controlled, vaccine trial in Guatemala to evaluate the efficacy of influenza immunization in pregnancy for protecting mothers and their infants. ..
  31. Pregnancy and EARly Lifestyle improvement Study (PEARLS)
    Kaumudi J Joshipura; Fiscal Year: 2013
    ....
  32. Adverse Outcomes of Assisted Reproductive Technologies: Genetics or Epigenetics?
    Margareta Pisarska; Fiscal Year: 2013
    ..the impact of infertility genetics and IVF-induced epigenetic changes on placental function and ultimately fetal development. Specifically, we propose to quantify and compare gene expression and CpG DNA methylation, as well as genome-..
  33. Pathogenesis/Treatment-Inherited Cholesterol Deficiency
    Gordon L Watson; Fiscal Year: 2013
    ..Aim 3) Correct cholesterol levels during fetal development. Here the emphasis is on preventive treatment and establishing when during development irreversible damage ..
  34. Adiponectin regulates nutrient transport in the placenta
    Theresa L Powell; Fiscal Year: 2009
    ..This research may lead to the development of intervention strategies to reduce birth weight in pregnancies of obese women, which will reduce the susceptibility to obesity in the next generation. ..
  35. Phthalate Exposure and Pregnancy Outcome
    T Peter Stein; Fiscal Year: 2010
    ..The findings will have ramifications for public health, for the packaging trade and for the chemical industry. ..
  36. Impact of Catecholamines to Insulin-Glucose Homeostasis in IUGR Fetuses
    Sean W Limesand; Fiscal Year: 2013
    ..Therefore, we plan to determine how a key stress response alters the developmental program in the fetal 2-cells to impair glucose homeostasis and lead to adulthood pathologies, such as Type 2 Diabetes Mellitus. ..
  37. Aging of brain: effects of perinatal nutrition
    Jan Krzysztof Blusztajn; Fiscal Year: 2010
    ..alters the patterns of gene expression, cell cycling, migration, apoptosis, and differentiation during fetal development and will study these processes in mutant mouse models. Dr...
  38. Effects of prenatal stress exposure on childhood physical and metabolic outcomes
    Kelsey Needham Dancause; Fiscal Year: 2013
    ..This is thought to reflect the effects of maternal stress hormones, which can cross the placenta and disrupt fetal development. Prenatal stress exposure might represent one of the mediating mechanisms in the Developmental Origins of ..
  39. Antenatal Dietary Supplementation is a Risk Factor for Infant Atopy Through Epige
    DAVID ALBERT SCHWARTZ; Fiscal Year: 2010
    ..utero dietary factors can modify the heritable risk of allergic airway disease during a vulnerable period of fetal development through epigenetic regulation in the form of enhanced DNA methylation...
  40. Human Decidual Leukocytes and Their Placental Ligands
    Jack L Strominger; Fiscal Year: 2013
    ....
  41. Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network
    Edward K Chien; Fiscal Year: 2013
    ..Focusing on significant perinatal and long-term outcomes, we will bring to an end procedures and practices that are ineffective or incur undue risks. ..
  42. Placental shape features, gestational timing and maternal and infant health
    Carolyn M Salafia; Fiscal Year: 2011
    ....
  43. Cellular Mechanisms of Amniotic Fluid Volume Regulation
    Cecilia Y Cheung; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A normal volume of amniotic fluid (AF) is essential for normal fetal development with favorable perinatal outcome...
  44. Deiodinase Activity as a Biomarker of Response to Brominated Flame Retardants
    Heather M Stapleton; Fiscal Year: 2012
    ..Thus normal functioning of this protein is critical to fetal development. Preliminary data generated by the PI's laboratory found an inverse relationship between PBDE body ..
  45. Role of Maternal Platelets in the Placenta and Pregnancy Complications
    Rashmi Sood; Fiscal Year: 2013
    ..These are much-needed investigations into platelet and coagulation activities at the feto-maternal interface with direct significance for pregnancy disorders. ..
  46. Effects of Lactational Exposure to Chromium (VI) on Ovarian Development
    SAKHILA BANU; Fiscal Year: 2010
    ..Cr(VI) is known to cause lung cancers, disrupt embryo and fetal development and induce reproductive abnormalities in women...
  47. Maternal-Fetal Conflict: The Effect of Imprinted Genes on Fetal Growth
    Ronald M Adkins; Fiscal Year: 2010
    ..Dietary survey instruments during pregnancy and just afterwards will be used to determine the maternal intake of nutrients vital to DNA methylation. Statistical analyses will be performed to test the three hypotheses. ..
  48. Adiponectin, placental nutrient transport and fetal growth
    Theresa L Powell; Fiscal Year: 2013
    ....
  49. The Common Marmoset as a Primate Model of Maternal Obesity
    SUZETTE D contact TARDIF; Fiscal Year: 2010
    ....
  50. Gestational Stress and Impaired Iron Homeostasis in the Young Infant
    Christopher L Coe; Fiscal Year: 2013
    ..The findings may reveal deficits that are amenable to prevention and treatment. ..
  51. A high-throughput screen for small-molecule antagonists of Gli function
    James K Chen; Fiscal Year: 2012
    ..provided by applicant): The Hedgehog (Hh) signaling pathway is integral to tissue patterning during fetal development and oncogenesis in children and adults...
  52. Effects of maternal cortisol on fetal and neonatal growth and metabolism
    Maureen Keller-Wood; Fiscal Year: 2013
    ..These studies will improve our understanding of the role of the normal increase in maternal cortisol that occurs in healthy pregnancies and how increases or decreases impact both fetal and neonatal growth and metabolism. ..
  53. Air pollution and fetal growth in China
    Yawei Zhang; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Disturbance of fetal development does not only put children at risk for mortality and morbidity in early life but also impair health in ..
  54. Fetal Nicotine Exposure and Chemosensory Plasticity
    Steven L Youngentob; Fiscal Year: 2010
    ..An understanding of these processes will facilitate the development and testing of preventive or therapeutic strategies. ..
  55. Mechanisms of Renal Vasodilation by Relaxin
    Kirk P Conrad; Fiscal Year: 2010
    ....
  56. Maternal pro-inflammatory status in obesity regulates placental function
    Theresa L Powell; Fiscal Year: 2013
    ..This is highly relevant to public health since this new information may lead to novel intervention strategies to alleviate fetal overgrowth, which could lessen the epidemic of obesity and diabetes in the next generation. ..
  57. Role of Hypoxia in Differentiation
    Ernestina Schipani; Fiscal Year: 2012
    ..not only in relation to pathological conditions such as cancer and ischemic diseases, but also in normal fetal development and in cell differentiation...
  58. Evolved placental response to hypoxa
    Stacy Zamudio; Fiscal Year: 2012
    ..This will provide us with a map for the development of clinical tests that detect when babies in utero are not growing normally and to design therapies to improve their growth and long-term health. ..
  59. Fetal Brain Damage: A Placental Disorder
    ANNA PENN; Fiscal Year: 2009
    ..Despite the importance of the placenta, our understanding of its role in fetal development, especially at a molecular level, is crude...
  60. Effects of Hypoxia on Craniofacial Morphology and Molecular Signaling
    FRANCIS JOEL SMITH; Fiscal Year: 2011
    ..that at least partially arise from environmental stresses including the lack of oxygen during embryonic and fetal development, as well as for devising new therapies to reverse these malformations...
  61. Cytoskeletal Regulation During Growth Cone Migration and Axon Guidance
    Frank B Gertler; Fiscal Year: 2012
    ..We seek a comprehensive understanding of how nerve fibers form and are guided to their targets initially during fetal development expecting that this will help us learn to repair damage to the brain.
  62. Ex Vivo Female Reproductive Tract Integration In a 3D Microphysiologic System
    Teresa K Woodruff; Fiscal Year: 2013
    ..mature, healthy gametes (oocytes) and providing the site for fertilization and an environment that supports fetal development. There are five main organs in the female reproductive tract-the ovary, fallopian tubes, uterus, cervix and ..
  63. Investigating the role of leptin in larval growth and limb development in Xenopus
    ERICA CRESPI; Fiscal Year: 2009
    ..that regulates food intake and metabolism in juvenile and adult mammals, the actions of leptin in early fetal development have been largely unexplored...
  64. ENDOTHELIAL CELL DIVERSITY DURING FETAL DEVELOPMENT
    Eugene Levin; Fiscal Year: 2001
    ..However, studies in the applicant's laboratory on the expression of endothelial cell proteins during fetal development indicate that endothelial cell gene expression also differs among vessel types and developmental stages even ..
  65. ETHANOL PLACENTO TOXICITY--INSULIN AND IGF-1 SIGNALLING
    Stanley Fisher; Fiscal Year: 1999
    ..The findings should also contribute to the general understanding of the mechanisms by which ethanol affects the biology of many human tissues, including those of the fetus. ..
  66. VULNERABILITY OF THE FETUS/INFANT TO PAH, PM2.5 AND ETS.
    Frederica Perera; Fiscal Year: 2004
    ....
  67. Dissociating hypoxia from pathology in preeclampsia and*
    Stacy Zamudio; Fiscal Year: 2007
    ..The advantage of this unique in vivo model is an unparalleled potential to elucidate the underlying pathological causes of preeclampsia and/or IUGR while controlling for the effects of placental hypoxia. [unreadable] [unreadable]..
  68. PARENTAL EMPLOYMENT AND CHILD DEVELOPMENT
    CHRISTOPHER RUHM; Fiscal Year: 2002
    ..Does parental employment during pregnancy affect the receipt of prenatal care, other maternal inputs into fetal development, birth weight, gestational age, or infant health? Does parental employment in the early years of the child's ..
  69. Endocrine Disruptors and Fetal Development
    Vasantha Padmanabhan; Fiscal Year: 2010
    ..of pregnant sheep to BPA at levels seen in human circulation will lead to low birthweight offspring by altering growth factor availability, and 3) if the effects of BPA on fetal development is carried across subsequent generations.
  70. Ambient Air Toxics and Adverse Birth Outcomes
    MICHELLE WILHELM TURNER; Fiscal Year: 2010
    ..provided by investigator): There is growing evidence that some air pollution constituents perturb fetal development. Some studies point to motor vehicle exhaust pollutants specifically as causative agents of interest...
  71. FETAL OXYGENATION AND GROWTH DURING MATERNAL ANEMIA
    DANIEL EDELSTONE; Fiscal Year: 1990
    ..These studies should enhance our understanding of the pathophysiology of the intrauterine hypoxia and fetal growth retardation that commonly complicate the pregnancies of chronically anemic women...
  72. Preterm Fetal Growth Restriction and Developmental Care
    Heidelise Als; Fiscal Year: 2009
    ..The study will be significant in understanding ways to reduce long-term functional morbidities in FGR infants, as well as in identifying opportunities for enhancing last trimester brain development. ..
  73. Individualized Norms of Optimal Fetal Growth
    Radek Bukowski; Fiscal Year: 2010
    ..Identifying physiologic determinants of fetal growth will also provide insight into mechanisms and abnormalities of human fetal growth. ..