embryonic development


Summary: Morphological and physiological development of EMBRYOS.

Top Publications

  1. pmc Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution
    Igor Ulitsky
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 147:1537-50. 2011
  2. ncbi The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes
    Tian Peng Gu
    Group of DNA Metabolism, The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Nature 477:606-10. 2011
  3. ncbi Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development
    Charles E Murry
    Departments of Pathology and Bioengineering, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA
    Cell 132:661-80. 2008
  4. ncbi Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs
    Antonio J Giraldez
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Science 312:75-9. 2006
  5. ncbi Targets and dynamics of promoter DNA methylation during early mouse development
    Julie Borgel
    Institute of Molecular Genetics, Centre National de la Recherche Scientifique CNRS UMR 5535, Universite Montpellier 2, Universite Montpellier 1, Montpellier, France
    Nat Genet 42:1093-100. 2010
  6. ncbi The maternal-to-zygotic transition: a play in two acts
    Wael Tadros
    Department of Molecular Genetics, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Development 136:3033-42. 2009
  7. pmc p53 activation by knockdown technologies
    Mara E Robu
    University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS Genet 3:e78. 2007
  8. pmc The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood
    Makiko Mizutani
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    J Immunol 188:29-36. 2012
  9. pmc UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development
    Karl B Shpargel
    Department of Genetics, Carolina Center for Genome Sciences, and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Genet 8:e1002964. 2012
  10. pmc Dynamic CpG island methylation landscape in oocytes and preimplantation embryos
    Sebastien A Smallwood
    Epigenetics Programme, The Babraham Institute, Cambridge, UK
    Nat Genet 43:811-4. 2011

Research Grants

Detail Information

Publications398 found, 100 shown here

  1. pmc Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution
    Igor Ulitsky
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 147:1537-50. 2011
    ..provides a roadmap for identification and analysis of lincRNAs in model organisms and shows that lincRNAs play crucial biological roles during embryonic development with functionality conserved despite limited sequence conservation.
  2. ncbi The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes
    Tian Peng Gu
    Group of DNA Metabolism, The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Nature 477:606-10. 2011
    ..Therefore, Tet3-mediated DNA hydroxylation is involved in epigenetic reprogramming of the zygotic paternal DNA following natural fertilization and may also contribute to somatic cell nuclear reprogramming during animal cloning...
  3. ncbi Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development
    Charles E Murry
    Departments of Pathology and Bioengineering, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA
    Cell 132:661-80. 2008
    ..The next challenge will be to demonstrate the functional utility of these cells, both in vitro and in preclinical models of human disease...
  4. ncbi Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs
    Antonio J Giraldez
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Science 312:75-9. 2006
    ..We also show that miR-430 accelerates the deadenylation of target mRNAs. These results suggest that miR-430 facilitates the deadenylation and clearance of maternal mRNAs during early embryogenesis...
  5. ncbi Targets and dynamics of promoter DNA methylation during early mouse development
    Julie Borgel
    Institute of Molecular Genetics, Centre National de la Recherche Scientifique CNRS UMR 5535, Universite Montpellier 2, Universite Montpellier 1, Montpellier, France
    Nat Genet 42:1093-100. 2010
    ..Finally, we identify nonimprinted genes that inherit promoter DNA methylation from parental gametes, suggesting that escape of post-fertilization DNA methylation reprogramming is prevalent in the mouse genome...
  6. ncbi The maternal-to-zygotic transition: a play in two acts
    Wael Tadros
    Department of Molecular Genetics, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Development 136:3033-42. 2009
    ..In this article, we discuss conserved and distinct features within the two component processes of the MZT...
  7. pmc p53 activation by knockdown technologies
    Mara E Robu
    University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS Genet 3:e78. 2007
    ..p53 inhibition could potentially be applicable to other systems to suppress off-target effects caused by other knockdown technologies...
  8. pmc The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood
    Makiko Mizutani
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    J Immunol 188:29-36. 2012
    ..We provide a novel model to monitor chemokine receptor expression changes in microglia and myeloid cells early (E8.0-E10.5) in development and during inflammatory conditions, which have been challenging to visualize in mammalian tissues...
  9. pmc UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development
    Karl B Shpargel
    Department of Genetics, Carolina Center for Genome Sciences, and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Genet 8:e1002964. 2012
    ..divergence of UTX and UTY in catalyzing H3K27 demethylation, they maintain functional redundancy during embryonic development. Our data suggest that UTX and UTY are able to regulate gene activity through demethylase independent ..
  10. pmc Dynamic CpG island methylation landscape in oocytes and preimplantation embryos
    Sebastien A Smallwood
    Epigenetics Programme, The Babraham Institute, Cambridge, UK
    Nat Genet 43:811-4. 2011
  11. pmc HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth
    Kelly L Covello
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 20:557-70. 2006
  12. ncbi Tgf-beta superfamily signaling in embryonic development and homeostasis
    Mary Y Wu
    Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Dev Cell 16:329-43. 2009
    ..Finally, we discuss how these ligands act as morphogens, how their activity and signaling range is regulated, and how they interact with other signaling pathways to achieve their specific and varied functional roles...
  13. pmc Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells
    Eran Meshorer
    National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Cell 10:105-16. 2006
  14. ncbi MicroRNA expression in zebrafish embryonic development
    Erno Wienholds
    Hubrecht Laboratory, Centre for Biomedical Genetics, 3584 CT Utrecht, The Netherlands
    Science 309:310-1. 2005
    ..Regulation by miRNAs can play essential roles in embryonic development. We determined the temporal and spatial expression patterns of 115 conserved vertebrate miRNAs in ..
  15. ncbi Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice
    Naotada Ishihara
    Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Nat Cell Biol 11:958-66. 2009
  16. ncbi Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy
    Philipp J Keller
    Cell Biology and Biophysics Unit, European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Science 322:1065-9. 2008
    ..We further derive a model of germ layer formation and show that the mesendoderm forms from one-third of the embryo's cells in a single event. Our digital embryos, with 55 million nucleus entries, are provided as a resource...
  17. pmc Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition
    Melissa M Harrison
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, USA
    PLoS Genet 7:e1002266. 2011
    ..This strong early association of ZLD with regions not active until the MZT suggests that ZLD is not only required for the earliest wave of transcription but also plays a major role in activating the genome at the MZT...
  18. pmc X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner
    G Grant Welstead
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 109:13004-9. 2012
    ..Lastly, ChIP-seq analysis revealed an increase in H3K27me3 in Utx-null male ES cells. In summary, our data demonstrate sex-specific requirements for this X-linked gene while suggesting a role for UTY during development...
  19. ncbi Epigenetic reprogramming in mammals
    Hugh D Morgan
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Hum Mol Genet 14:R47-58. 2005
    ..A mechanistic understanding of reprogramming will be crucial for medical applications of stem cell technology...
  20. pmc Progressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development
    Zhe Ji
    Department of Biochemistry and Molecular Biology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Proc Natl Acad Sci U S A 106:7028-33. 2009
    ..Here, we report that mouse genes tend to express mRNAs with longer 3' UTRs as embryonic development progresses...
  21. ncbi Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development
    Stefan Bonn
    Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    Nat Genet 44:148-56. 2012
    ..This cell type-specific view identifies dynamic enhancer usage, an essential step in deciphering developmental networks...
  22. ncbi PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos
    Toshinobu Nakamura
    Department of Pathology, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Nature 486:415-9. 2012
    ..This type of regulatory mechanism could be involved in DNA modifications in somatic cells as well as in early embryos...
  23. ncbi Autophagy gene-dependent clearance of apoptotic cells during embryonic development
    Xueping Qu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 128:931-46. 2007
    ..Moreover, mice lacking atg5 display a defect in apoptotic corpse engulfment during embryonic development. We conclude that autophagy contributes to dead-cell clearance during PCD by a mechanism that likely ..
  24. pmc Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway
    Petra Hajkova
    Wellcome Trust Cancer Research U K Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Science 329:78-82. 2010
    ..We demonstrate that DNA repair through BER represents a core component of genome-wide DNA demethylation in vivo and provides a mechanistic link to the extensive chromatin remodeling in developing PGCs...
  25. pmc Deterministic and stochastic allele specific gene expression in single mouse blastomeres
    Fuchou Tang
    Wellcome Trust Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e21208. 2011
  26. pmc Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development
    Azusa Inoue
    Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cell Res 21:1670-6. 2011
    ..Together with previous studies, our study suggests that Tet-catalyzed conversion of 5mC to 5hmC/5fC/5caC followed by replication-dependent dilution accounts for paternal DNA demethylation during preimplantation development...
  27. pmc Shadow enhancers as a source of evolutionary novelty
    Joung Woo Hong
    Department of Molecular and Cell Biology, Division of Genetics, Genomics, and Development, Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA
    Science 321:1314. 2008
  28. ncbi G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis
    Nirit Feldman
    Department of Experimental Medicine, Hebrew University Medical School, Ein Kerem, Jerusalem 91120, Israel
    Nat Cell Biol 8:188-94. 2006
    ..Genetic studies show that these epigenetic changes actually have an important role in the inhibition of Oct-3/4 re-expression, thereby preventing reprogramming...
  29. ncbi Visualization of an endogenous retinoic acid gradient across embryonic development
    Satoshi Shimozono
    Laboratory for Cell Function Dynamics, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    Nature 496:363-6. 2013
    ..Live imaging of endogenous concentration gradients across embryonic development will allow the precise assignment of molecular mechanisms to developmental dynamics and will accelerate ..
  30. ncbi Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse
    Janet Rossant
    Research Institute, The Hospital for Sick Children and Departments of Molecular Genetics, and Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada
    Development 136:701-13. 2009
    ..We also discuss the continuing debate that surrounds the relative impacts of early lineage bias versus the stochastic allocation of cells with respect to the events that pattern the blastocyst and initiate its later asymmetries...
  31. pmc Temporal coordination of gene networks by Zelda in the early Drosophila embryo
    Chung Yi Nien
    Department of Biology, Center for Developmental Genetics, New York University, New York, New York, USA
    PLoS Genet 7:e1002339. 2011
    ..We propose that Zld promotes timely and robust transcriptional activation of early-gene networks so that developmental events are coordinated and cell fates are established properly in the cellular blastoderm embryo...
  32. pmc TDP-43 is a developmentally regulated protein essential for early embryonic development
    Chantelle F Sephton
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 285:6826-34. 2010
    ..In this study, we show that TDP-43 is a nuclear protein with persistent high-level expression during embryonic development and with progressively decreased protein levels during postnatal development...
  33. pmc Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development
    Yann Gaël Gangloff
    Genome Research Institute, University of Cincinnati, 2180 E Galbraith Rd, Cincinnati, OH 45237, USA
    Mol Cell Biol 24:9508-16. 2004
    ..In contrast to the situation in mTOR(+/-) mice, embryonic development of homozygous mTOR(-/-) mice appears to be arrested at E5...
  34. pmc Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development
    Ryutaro Hirasawa
    Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima 411 8540, Japan
    Genes Dev 22:1607-16. 2008
    ..The methylation marks or imprints are established in the parental germline and maintained throughout embryonic development. However, it is unclear how the methylation imprints are maintained through extensive demethylation in ..
  35. ncbi Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
    L Luo
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco 94143
    Genes Dev 8:1787-802. 1994
    ..Expressions of analogous mutant Dcdc42 proteins cause qualitatively distinct morphological defects, suggesting that similar GTPases in the same subfamily have unique roles in morphogenesis...
  36. ncbi Low doses of pristine and oxidized single-wall carbon nanotubes affect mammalian embryonic development
    Antonio Pietroiusti
    Department of Biopathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    ACS Nano 5:4624-33. 2011
    ..The EST predicted the in vivo data, identifying oxidized SWCNTs as the more toxic compound...
  37. pmc The C. elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity
    Julien Vandamme
    Biotech Research and Innovation Centre BRIC, University of Copenhagen, Copenhagen, Denmark
    PLoS Genet 8:e1002647. 2012
    ..Taken together, these results demonstrate that UTX-1 is required for many aspects of nematode development; but, unexpectedly, this function is independent of its enzymatic activity...
  38. pmc Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development
    Renée van Amerongen
    Department of Developmental Biology and Howard Hughes Medical Institute, Lorry I Lokey Stem Cell Research Building, Stanford University, Stanford, CA 94305, USA
    Dev Biol 369:101-14. 2012
    b>Embryonic development is controlled by a small set of signal transduction pathways, with vastly different phenotypic outcomes depending on the time and place of their recruitment...
  39. pmc Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation
    James A Goodrich
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, Colorado 80309, USA
    Nat Rev Genet 11:549-58. 2010
    ..Furthermore, new roles for components of these complexes have been identified beyond development; for example, in mediating interactions with chromatin and in maintaining active gene expression across cell divisions...
  40. pmc Human pre-implantation embryo development
    Kathy K Niakan
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    Development 139:829-41. 2012
  41. pmc Global analysis of patterns of gene expression during Drosophila embryogenesis
    Pavel Tomancak
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Genome Biol 8:R145. 2007
    Cell and tissue specific gene expression is a defining feature of embryonic development in multi-cellular organisms...
  42. pmc The conserved miR-51 microRNA family is redundantly required for embryonic development and pharynx attachment in Caenorhabditis elegans
    W Robert Shaw
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom
    Genetics 185:897-905. 2010
    ..The miR-51 family is redundantly required for embryonic development. mir-51 family mutants display a highly penetrant pharynx unattached (Pun) phenotype, where the pharyngeal ..
  43. ncbi A genetic screen for mutations affecting embryogenesis in zebrafish
    W Driever
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Development 123:37-46. 1996
    ..This screen demonstrates that mutations affecting a variety of developmental processes can be efficiently recovered from zebrafish...
  44. ncbi Small non-coding RNAs in animal development
    Giovanni Stefani
    Department of Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06520, USA
    Nat Rev Mol Cell Biol 9:219-30. 2008
    ..These studies show that miRNAs are key regulators of animal development and are potential human disease loci...
  45. pmc Fate tracing reveals the endothelial origin of hematopoietic stem cells
    Ann C Zovein
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Cell Stem Cell 3:625-36. 2008
    ..Moreover, AGM mesenchyme, as selectively traced via a myocardin Cre line, is incapable of hematopoiesis. Our genetic tracing strategy therefore reveals an endothelial origin of HSCs...
  46. ncbi Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans
    B Sönnichsen
    Cenix BioScience GmbH, Tatzberg 47 51, D 01307 Dresden, Germany
    Nature 434:462-9. 2005
  47. pmc A role for the elongator complex in zygotic paternal genome demethylation
    Yuki Okada
    Howard Hughes Medical Institute, Chapel Hill, North Carolina 27599 7295, USA
    Nature 463:554-8. 2010
  48. ncbi Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth
    Annie Varrault
    Institut de Genomique Fonctionnelle, CNRS UMR5203, INSERM U661, Universite Montpellier 1, Universite Montpellier 2, Montpellier, F 34094, France
    Dev Cell 11:711-22. 2006
    ..Accordingly, these data identify a network of imprinted genes, including Zac1, which controls embryonic growth and which may be the basis for the implementation of a common mechanism of gene regulation during mammalian evolution...
  49. pmc Dynamic stage-specific changes in imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes
    Shin Ichi Tomizawa
    Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima, Japan
    Development 138:811-20. 2011
    ..These results provide evidence for a unique methylation profile in oocytes and reveal the surprisingly dynamic nature of DMRs in the early embryo...
  50. pmc RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryos
    Shogo Matoba
    RIKEN BioResource Center, Tsukuba, Ibaraki 305 0074, Japan
    Proc Natl Acad Sci U S A 108:20621-6. 2011
    ..after implantation because of unidentified, complex epigenetic errors in the process of postimplantation embryonic development. Here we identify the most upstream level of dysfunction leading to impaired development of clones by ..
  51. ncbi A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A
    Riki Kawaguchi
    Department of Physiology, David Geffen School of Medicine at UCLA, 650 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Science 315:820-5. 2007
    ..It is widely expressed in embryonic development and in adult organ systems...
  52. ncbi Histone deacetylase HDAC1/HDAC2-controlled embryonic development and cell differentiation
    Reinhard Brunmeir
    Max F Perutz Laboratories, Medical University of Vienna, Vienna Biocenter, Vienna, Austria
    Int J Dev Biol 53:275-89. 2009
  53. pmc Brachyury establishes the embryonic mesodermal progenitor niche
    Benjamin L Martin
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Genes Dev 24:2778-83. 2010
    ..Thus, the embryonic mesodermal progenitors uniquely establish their own niche--with Brachyury being essential for creating a domain of high Wnt and low RA signaling--rather than having a niche created by separate support cells...
  54. ncbi Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality
    L E Stephens
    Department of Stomatology, University of California, San Francisco 94143 0512, USA
    Genes Dev 9:1883-95. 1995
    ..To determine when beta 1 integrins become critical during embryonic development, we generated mutant mice with a targeted disruption of the beta 1 integrin subunit gene...
  55. ncbi Small peptides switch the transcriptional activity of Shavenbaby during Drosophila embryogenesis
    T Kondo
    Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology NIBB, National Institutes of Natural Sciences, 5 1 Myodaiji Higashiyama, Okazaki 444 8787, Japan
    Science 329:336-9. 2010
    ..Our results demonstrate that during Drosophila embryogenesis, Pri sORF peptides provide a strict temporal control to the transcriptional program of epidermal morphogenesis...
  56. ncbi PGC7/Stella protects against DNA demethylation in early embryogenesis
    Toshinobu Nakamura
    Department of Pathology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka 565 0871, Japan
    Nat Cell Biol 9:64-71. 2007
    ..These results demonstrate that PGC7/Stella is indispensable for the maintenance of methylation involved in epigenetic reprogramming after fertilization...
  57. ncbi Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage
    Connie C Wong
    Institute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, California, USA
    Nat Biotechnol 28:1115-21. 2010
    ..These studies indicate that success and failure in human embryo development is largely determined before EGA. Our methods and algorithms may provide an approach for early diagnosis of embryo potential in assisted reproduction...
  58. pmc EMAGE mouse embryo spatial gene expression database: 2010 update
    Lorna Richardson
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh EH4 2XU, UK
    Nucleic Acids Res 38:D703-9. 2010
  59. pmc Dynamic reprogramming of chromatin accessibility during Drosophila embryo development
    Sean Thomas
    Department of Genome Sciences, University of Washington, Foege S310A, 1705 NE Pacific Street, Box 355065, Seattle, WA 98195, USA
    Genome Biol 12:R43. 2011
    ..Understanding the scope and features of chromatin dynamics during embryogenesis, and identifying regulatory elements important for directing developmental processes remain key goals of developmental biology...
  60. ncbi The placenta is a niche for hematopoietic stem cells
    Christos Gekas
    Department of Pediatric Oncology, Dana Farber Cancer Institute and, Childrens Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Cell 8:365-75. 2005
    ..Importantly, the placental HSC pool is not explained by rare circulating HSCs, which appear later. These data support an important, but unappreciated, role for the placenta in establishing the mammalian definitive hematopoietic system...
  61. pmc Rewirable gene regulatory networks in the preimplantation embryonic development of three mammalian species
    Dan Xie
    Department of Bioengineering, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Genome Res 20:804-15. 2010
    Mammalian preimplantation embryonic development (PED) is thought to be governed by highly conserved processes...
  62. pmc Understanding the role of growth factors in embryonic development: insights from the lens
    F J Lovicu
    Discipline of Anatomy and Histology, Bosch Institute, University of Sydney, NSW 2006, Australia
    Philos Trans R Soc Lond B Biol Sci 366:1204-18. 2011
    ..In the case of the epithelium, key roles for Wnt/β-catenin and Notch signalling have been demonstrated in embryonic development, but it is not known if other factors are required for its formation and maintenance...
  63. pmc Genome-wide occupancy links Hoxa2 to Wnt-β-catenin signaling in mouse embryonic development
    Ian J Donaldson
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    Nucleic Acids Res 40:3990-4001. 2012
    ..ChIP-seq) to identify Hoxa2 genomic locations in a time and space when it is actively instructing embryonic development in mouse...
  64. pmc The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse
    Helen Waller-Evans
    Department of Biochemistry and Magdalen College, University of Oxford, Oxford, United Kingdom
    PLoS ONE 5:e14047. 2010
    ..The physiological function of GPR126 in mammals is still unknown. We describe a targeted mutation of GPR126 in the mouse, and show that GPR126 is required for embryonic viability and cardiovascular development...
  65. ncbi Fibroblast growth factor requirements for in vitro development of bovine embryos
    Sarah D Fields
    Department of Animal Sciences, University of Florida, Gainesville, FL, USA
    Theriogenology 75:1466-75. 2011
    ..In conclusion, FGF receptor activation was important for optimal blastocyst formation and FGF2 supplementation increased bovine blastocyst formation when provided at high concentrations...
  66. pmc Making the blastocyst: lessons from the mouse
    Katie Cockburn
    Department of Molecular Genetics, University of Toronto, Canada
    J Clin Invest 120:995-1003. 2010
    ..A greater understanding of the similarities and differences between mouse and human preimplantation development has implications for improving assisted reproductive technologies and for deriving human embryonic stem cells...
  67. ncbi Fibroblast growth factor receptors in in vitro and in vivo chondrogenesis: relating tissue engineering using adult mesenchymal stem cells to embryonic development
    Catharine A Hellingman
    Department of Otorhinolaryngology, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Tissue Eng Part A 16:545-56. 2010
    ..Because tissue regeneration and embryonic development may involve similar pathways, understanding common pathways may lead to advances in regenerative medicine...
  68. pmc Maternal microRNAs are essential for mouse zygotic development
    Fuchou Tang
    Wellcome Trust Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QN, United Kingdom
    Genes Dev 21:644-8. 2007
    ..with the notion that a large proportion of the maternal genes are directly or indirectly under the control of miRNAs, which demonstrates that the maternal miRNAs are essential for the earliest stages of mouse embryonic development.
  69. pmc SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development
    Xunlei Kang
    The Department of Biochemistry and Molecular and Cell Biology, The Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Mol Cell 38:191-201. 2010
    ..Our results reveal a critical role for de-SUMOylation in the regulation of PcG target gene expression...
  70. ncbi Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
    Shinji Masui
    Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology, Minatojima minamimachi 2 2 3, Chu o ku, Kobe, Hyogo 650 0047, Japan
    Nat Cell Biol 9:625-35. 2007
    ..These results indicate that the essential function of Sox2 is to stabilize ES cells in a pluripotent state by maintaining the requisite level of Oct3/4 expression...
  71. pmc Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation
    Ssang Taek Lim
    Department of Reproductive Medicine, Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, MC0803, La Jolla, CA 92093, USA
    Mol Cell 29:9-22. 2008
    ..These studies define a scaffolding role for nuclear FAK in facilitating cell survival through enhanced p53 degradation under conditions of cellular stress...
  72. ncbi Epigenetic temporal control of mouse Hox genes in vivo
    Natalia Soshnikova
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Science 324:1320-3. 2009
    ..These results suggest that chromatin modifications are important parameters in the temporal regulation of this gene family...
  73. pmc Zscan4: a novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells
    Geppino Falco
    Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Dev Biol 307:539-50. 2007
    ..Zscan4 thus seems to be essential for preimplantation development...
  74. pmc The genome of the sea urchin Strongylocentrotus purpuratus
    Erica Sodergren
    Science 314:941-52. 2006
    ..This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes...
  75. pmc Combined transcriptome and proteome analysis identifies pathways and markers associated with the establishment of rapeseed microspore-derived embryo development
    Ronny Joosen
    Business Units Bioscience, Plant Research International, 6700 AA Wageningen, The Netherlands
    Plant Physiol 144:155-72. 2007
  76. pmc Maternal control of early mouse development
    Lei Li
    Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Development 137:859-70. 2010
    ..Nevertheless, significant gaps remain in our mechanistic understanding of the networks that regulate early mammalian embryogenesis, which provide an impetus and opportunities for future investigations...
  77. ncbi Colony-stimulating factor 2 inhibits induction of apoptosis in the bovine preimplantation embryo
    Barbara Loureiro
    Department of Animal Sciences and D H Barron Reproductive and Perinatal Biology Research Program, University of Florida, Gainesville, FL 32611 0910, USA
    Am J Reprod Immunol 65:578-88. 2011
    ..Addition of colony-stimulating factor 2 (CSF2) to culture medium increases post-transfer survival of bovine embryos. Here we provide evidence that one mechanism by which CSF2 affects the embryo is through inhibition of apoptosis...
  78. pmc Colony-stimulating factor 2 (CSF-2) improves development and posttransfer survival of bovine embryos produced in vitro
    Barbara Loureiro
    Department of Animal Sciences, University of Florida, Gainesville, Florida 32611 0910, USA
    Endocrinology 150:5046-54. 2009
    ..of colony-stimulating factor 2 (CSF2) as one of the regulatory molecules that mediate maternal effects on embryonic development during the preimplantation period...
  79. ncbi Histone modifications at the blastocyst Axin1(Fu) locus mark the heritability of in vitro culture-induced epigenetic alterations in mice
    Raul Fernandez-Gonzalez
    Departamento de Reproduccion Animal, INIA, Madrid, Spain
    Biol Reprod 83:720-7. 2010
    ..insertion upstream of the Axin1 gene) we sought to establish the heritable mark during early embryonic development that determines transgenerational epigenetic inheritance and to examine a possible shift in the expression ..
  80. ncbi A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development
    Yi Lin Yan
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 132:1069-83. 2005
    ..By contrast, subfunction partitioning between zebrafish co-orthologs of tetrapod genes, such as sox9a and sox9b, can relax pleiotropy and reveal both early and late developmental gene functions...
  81. pmc Significant improvement in cloning efficiency of an inbred miniature pig by histone deacetylase inhibitor treatment after somatic cell nuclear transfer
    Jianguo Zhao
    National Swine Resource and Research Center, Division of Animal Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Biol Reprod 81:525-30. 2009
    ..05). In conclusion, the extremely low cloning efficiency in the NIH miniature pig may be caused by its inbred genetic background and can be improved by alteration of genomic histone acetylation patterns...
  82. pmc Mammalian alteration/deficiency in activation 3 (Ada3) is essential for embryonic development and cell cycle progression
    Shakur Mohibi
    Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198 5805, USA
    J Biol Chem 287:29442-56. 2012
    ..Taken together, we provide evidence for a critical role of Ada3 in embryogenesis and cell cycle progression as an essential component of HAT complex...
  83. ncbi Select nutrients and their associated transporters are increased in the ovine uterus following early progesterone administration
    M Carey Satterfield
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 82:224-31. 2010
    ..Thus, select nutrients are increased in the uterine lumen by P4 concomitant with the upregulation of epithelial transporters for glucose and basic amino acids, suggesting that these nutrients stimulate blastocyst growth and development...
  84. pmc Maternal serotonin is crucial for murine embryonic development
    Francine Cote
    Universite Pierre et Marie Curie, Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus Neurodegeneratifs, CNRS, Unité Mixte de Recherche 7091, Hopital de la Pitie Salpetriere, Paris, France
    Proc Natl Acad Sci U S A 104:329-34. 2007
    ..Consideration of the maternal genotype may thus help to clarify the influence of other genes in complex diseases, such as mental illness...
  85. pmc Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse
    Sangphil Oh
    National Research Laboratory of Molecular Genetics, Department of Biological Science, KAIST, Daejeon 305 701, South Korea
    Mol Cell Biol 29:6309-20. 2009
    ..These findings indicate that both Mst1 and Mst2 kinases play essential roles in early mouse development, regulating placental development, vascular patterning, primitive hematopoiesis, and cell proliferation and survival...
  86. pmc Perspectives and open problems in the early phases of left-right patterning
    Laura N Vandenberg
    Center for Regenerative and Developmental Biology, Biology Department, Tufts University, Medford, MA 02155, USA
    Semin Cell Dev Biol 20:456-63. 2009
  87. pmc Transcriptome profiling of human pre-implantation development
    Pu Zhang
    Department of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 4:e7844. 2009
    ..Preimplantation development is a crucial step in early human development. However, the molecular basis of human preimplantation development is not well known...
  88. ncbi Comparison of survival and embryonic development in human oocytes cryopreserved by slow-freezing and vitrification
    Yun Xia Cao
    Center for Reproductive Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, People s Republic of China
    Fertil Steril 92:1306-11. 2009
    To compare the survival, fertilization, early embryonic development, and meiotic spindle assembly and chromosome alignment in frozen-thawed human oocytes after slow-freezing and vitrification.
  89. ncbi Effect of limited DNA methylation reprogramming in the normal sheep embryo on somatic cell nuclear transfer
    Nathalie Beaujean
    Division of Gene Expression and Development, Roslin Institute, Roslin EH25 9PS, United Kingdom
    Biol Reprod 71:185-93. 2004
    ..a functional zygotic nucleus is thought to be an important function of the oocyte cytoplasm for subsequent embryonic development in the mouse...
  90. pmc Essential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression
    El Bachir Affar
    Harvard Medical School, Department of Pathology, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Mol Cell Biol 26:3565-81. 2006
    ..These data not only shed new light on the molecular basis for YY1 developmental roles and cellular functions, but also provide insight into the general mechanisms controlling eukaryotic cell proliferation, apoptosis, and differentiation...
  91. ncbi Wnt1-cre-mediated conditional loss of Dicer results in malformation of the midbrain and cerebellum and failure of neural crest and dopaminergic differentiation in mice
    Tianwen Huang
    State Key Laboratory of Neuroscience, Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    J Mol Cell Biol 2:152-63. 2010
    ..Here, we investigated the global function of miRNAs in embryonic development by examining the Wnt1-cre-mediated Dicer knockout mice...
  92. ncbi Autophagy is essential for preimplantation development of mouse embryos
    Satoshi Tsukamoto
    Department of Physiology and Cell Biology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Science 321:117-20. 2008
    ..Protein synthesis rates were reduced in the autophagy-null embryos. Thus, autophagic degradation within early embryos is essential for preimplantation development in mammals...
  93. ncbi Effect of carbon nanotubes on developing zebrafish (Danio rerio) embryos
    Jinping Cheng
    Department of Biology and Chemistry, City University of Hong Kong, Hong Kong, People s Republic of China
    Environ Toxicol Chem 26:708-16. 2007
    ..Molecular and cellular analysis showed that the embryonic development of the exposed embryos up to 96 hpf was not affected at SWCNT concentrations of up to 360 mg/L...
  94. ncbi Serotonin transporter function is an early step in left-right patterning in chick and frog embryos
    Takahiro Fukumoto
    Cytokine Biology Department, The Forsyth Institute, Harvard Medical School, Boston, Mass 02115, USA
    Dev Neurosci 27:349-63. 2005
    ..Taken together our data characterize two new right-sided markers in chick gastrulation, identify a novel, early component of the left-right pathway in two vertebrate species, and reveal a new biological role for serotonin transport...
  95. pmc The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development
    Ryan S Gray
    Dept of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712, USA
    Nat Cell Biol 11:1225-32. 2009
    The planar cell polarity (PCP) signalling pathway is essential for embryonic development because it governs diverse cellular behaviours, and 'core PCP' proteins, such as Dishevelled and Frizzled, have been extensively characterized...
  96. ncbi Cre activity causes widespread apoptosis and lethal anemia during embryonic development
    L A Naiche
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Genesis 45:768-75. 2007
    ..This information will be critical in both evaluating previously published work using cre alleles and in designing future experiments...
  97. pmc Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3
    Angèle Santenard
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre national de la recherche scientifique Institut National de la Santé et de la Recherche Médicale U964, Universite de Strasbourg, F 67404 Illkirch, France
    Nat Cell Biol 12:853-62. 2010
    ..Our work demonstrates a role for a modifiable residue within a histone-variant-specific context during reprogramming and identifies a novel function for mammalian H3.3 in the initial formation of dsRNA-dependent heterochromatin...
  98. ncbi PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos
    Mareike Puschendorf
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nat Genet 40:411-20. 2008
    ..Parental epigenetic asymmetry, also observed along cleavage chromosomes, is resolved by the end of the 8-cell stage--concurrent with blastomere polarization--marking the end of the maternal-to-embryonic transition...
  99. pmc Lin9, a subunit of the mammalian DREAM complex, is essential for embryonic development, for survival of adult mice, and for tumor suppression
    Nina Reichert
    University of Wuerzburg, Department of Physiological Chemistry I, Biocenter, Wuerzburg, Germany
    Mol Cell Biol 30:2896-908. 2010
    ..We found that LIN9 is essential for early embryonic development and for viability of adult mice...
  100. ncbi Transcriptome profiling of embryonic development rate in rainbow trout advanced backcross introgression lines
    Peng Xu
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Mar Biotechnol (NY) 13:215-31. 2011
    In rainbow trout (Oncorhynchus mykiss) and other fishes, embryonic development rate is an ecologically and evolutionarily important trait that is closely associated with survival and physiological performance later in life...
  101. pmc Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development
    Anthony Ng
    Section of Molecular Cell and Developmental Biology, Institute for Cell and Molecular Biology, The University of Texas at Austin, Austin, TX 78722, USA
    Development 136:2601-11. 2009
    ..signaling are crucial for numerous biochemical and cellular processes, their functions during vertebrate embryonic development have not been well characterized...

Research Grants110 found, 100 shown here

  1. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
    Melanie H Cobb; Fiscal Year: 2012
    ..WNK1 is essential for embryonic development in mice. The best known function of WNK family members is their influence on ion balance...
  3. Structural Basis for Chemokine Function
    Brian F Volkman; Fiscal Year: 2013
    ..RELEVANCE: Chemokines orchestrate innate immune responses injury or infection, and also participate in embryonic development, stem cell homing, chronic inflammation, HIV infection and cancer metastasis...
    Alvaro Puga; Fiscal Year: 2013
    ..during cardiovascular development that result from TCDD exposure;(3) to determine if TCDD exposure during embryonic development causes long-lasting cardiovascular malformations...
  5. Characterization of epsilon-sarcoglycan interacting proteins in mouse brain
    Yuqing Li; Fiscal Year: 2012
    ..SGCE is widely expressed in embryonic development and in adults. SGCE is expressed in almost all brain regions tested...
  6. Modifiers of Cyst Progression in Polycystic Kidney Disease
    Phillip Darwin Bell; Fiscal Year: 2013
    ..During embryonic development, deletion of cilia or mutations in cystoproteins such as polycystin 1 and 2 lead to PKD...
    Michael R Green; Fiscal Year: 2013
    ..We have identified a single TRF3 target gene, mespa, which is required for early embryonic development and commitment of mesoderm to the hematopoietic lineage...
  8. Interaction between RNA interference and RNA editing pathways
    Kazuko Nishikura; Fiscal Year: 2013
    ..Specifically, we will determine: 1) the significance of certain miRNAs that are edited during embryonic development for regulation of apoptosis;2) the significance of A I editing of repetitive non-coding RNAs for control ..
  9. BMP signaling in vertebrate development
    Ken W Y Cho; Fiscal Year: 2013
    ..The roles of BMPs have diverged in evolution and include the control of gametogenesis, early embryonic development, cell differentiation/apoptosis, and tissue homeostasis in the adult...
  10. The Role of MYST Histone Acetyltransferase in Genome Stability
    M Mitchell Smith; Fiscal Year: 2013
    ..MYST acetyltransferases are required for early mammalian embryonic development and aberrant rearrangements or regulation of MYST genes are associated with human cancers...
  11. Analysis of epigenetic regulation in early mammalian embryos via RNA interference
    Charles R Long; Fiscal Year: 2010
    ..Mammalian epigenetic marks are first erased and subsequently re-established during early embryonic development, concomitant with the period of embryo culture following IVF in fertility clinics...
  12. Novel Collagen II Alternative Transcripts and Mouse Skeletal Development
    Audrey McAlinden; Fiscal Year: 2010
    ..is an essential mechanism required for proper formation of cartilage (and possibly other tissues) during embryonic development. We therefore propose to (1) generate a recombinant knock-in mouse model with an inactivated IIC splice ..
    Moosa Mohammadi; Fiscal Year: 2013
    ..The data obtained under Aim I should provide molecular insights into the roles of paracrine FGFs in embryonic development and also facilitate the discovery of drugs for tissue repair and bioengineering, promotion of self- ..
  14. Heat Shock Effects on Human Mesenchymal Stem Cell Differentiation in Hydrogel
    Sihong Wang; Fiscal Year: 2010
    ..In addition, the upregulation of heat shock proteins (HSPs) and their important roles in embryonic development have been widely recognized...
  15. Developing a murine model for arsenic-induced skin neoplasm
    Mohammad Athar; Fiscal Year: 2010
    ..The Shh signaling pathway is one of the most fundamental signal transduction pathways during embryonic development. In this proposal, we will investigate whether aberrant activation of shh pathway is involved in the ..
  16. VEGF Regulation of Hepatic Erythropoietin Synthesis
    Calvin Kuo; Fiscal Year: 2009
    ..erythropoietin levels are elevated in parallel;however, the Epo originates from the liver as in embryonic development, not the usual site of synthesis in the kidney...
  17. Analysis of FIP200 in signal transduction
    Jun Lin Guan; Fiscal Year: 2012
    ..Protein of 200 kDa) in the regulation of cell growth, proliferation, and apoptosis in breast cancer and embryonic development. We identified a novel interaction between FIP200 and TSC1 and showed that this interaction negatively ..
    Christopher E Turner; Fiscal Year: 2012
    Cell migration is essential for normal embryonic development, tissue repair and immune surveillance, but is also a contributing factor in mental retardation, developmental defects, tumor cell invasion and tissue fibrosis...
    Gary W Conrad; Fiscal Year: 2012
    ..is to understand the biological physical chemistry of the corneal extracellular matrix (ECM) during embryonic development and be able to repair that ECM in adults...
  20. Ecd as a regulator of cell cycle and breast oncogenesis
    Vimla Band; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Precisely regulated cell proliferation is essential for embryonic development as well as homeostasis in adult organs and tissues, whereas uncontrolled cell proliferation is a hallmark of cancer...
  21. Regulation of TGF-beta Signaling and Embryonic Development by GTPases
    Gerald H Thomsen; Fiscal Year: 2010
    ..Our studies will provide crucial information about GTPBPs which may eventually translate into clinical treatments for diseases caused by abnormal TGF[unreadable] or GTPBP signaling. ..
  22. CYP1B1, NF-kB , and Regulation of Angiogenesis
    TAMMY LYNN PALENSKI; Fiscal Year: 2012
    ..from pre-existing capillaries, is very tightly regulated and normally does not occur except during embryonic development and reparative processes in the adult...
  23. PAX2 gene targets, binding sites and function
    Patrick D Brophy; Fiscal Year: 2010
    ..During embryonic development, Pax2 is required for the initiation and maintenance of the conversion of the renal mesenchyme to ..
  24. PTIP as an epigenetic regulator in male meiosis
    Guo Zhang Zhu; Fiscal Year: 2013
    ..lately identified as part of a histone H3 lysine 4 (H3K4) methyltransferase complex and is essential for embryonic development. H3K4 methylation is an epigenetic mark and is involved in the regulation of genome function through ..
  25. Laser Spinning Disc Confocal System for live-cell and live-organism microscopy
    Martha C Soto; Fiscal Year: 2012
    ..C. elegans studies of the regulation of the actin cytoskeleton by the Extracellular Matrix during embryonic development in the Soto Lab are identifying new roles for axonal guidance molecules organizing tissues, and ..
  26. Role of POZ-zinc finger proteins in tumorigenesis.
    Pier Paolo Pandolfi; Fiscal Year: 2013
    ..that shares structural similarities with BCL6 and PLZF and plays a critical and essential role in embryonic development, hematopoiesis and hematological malignancies...
  27. Embryonic Gene Expression During Diabetic Embryopathy
    Mary R Loeken; Fiscal Year: 2013
    ..Oxidative stress, resulting from excessive glucose metabolism by the embryo, early during embryonic development, is responsible for these malformations...
  28. Targets of a cytidine deaminase required for left-right axis in Xenopus
    Alin Vonica; Fiscal Year: 2010
    ..enzymes of the cytidine deaminase family have been connected to important processes in adults, but not to embryonic development. The investigator found the cytidine deaminase XAPOBEC-2 (Xenopus apoB editing catalytic subunit 2, XA2) ..
  29. Developmental Physiology of Ciliated Epithelia
    ..The larval skin is one of the earliest organs to form during embryonic development, can be easily imaged, and is extremely tractable to a genetic analysis...
  30. Elucidating the in vivo Role of the p53 Apoptosis-Specific Target Gene Siva
    Jeanine L Frey; Fiscal Year: 2013
    ..our studies using Siva null mice we generated have revealed a critical role for Siva during early embryonic development. Siva-deficiency results in embryonic lethality associated with defects in extra-embryonic vasculature ..
  31. Transcription Factor Cross-Talk in Developmental Toxicity
    LARISSA WILLIAMS; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Sensitivity to toxicants is often enhanced during embryonic development, when exposure to low levels of chemicals can disrupt developmental process and lead to disease...
  32. Leukemia Inhibitory Factor As a Mediator of Primate Ovulation &Oocyte Maturation
    Jon D Hennebold; Fiscal Year: 2013
    ..follicle resulting in the release of a mature ovum (ovulation) that fertilizes and undergoes subsequent embryonic development are incompletely defined...
  33. Intralipid: A novel frontline countermeasure for brodifacoum poisoning
    Douglas L Feinstein; Fiscal Year: 2013
    ..In addition, in utero exposure to warfarin has adverse effects on embryonic development, suggesting the in utero exposure to superwarfarins could have disastrous outcomes...
  34. Oncogenic Kit receptor signaling in vivo
    Peter Besmer; Fiscal Year: 2012
    ..receptor tyrosine kinases such as Kit mediate distinct cellular responses in different cell types during embryonic development and in the postnatal animal? And what are the requirements for oncogenic transformation in different cell ..
  35. Contribution of Sperm Nucleus to Paternal DNA Replication
    WILLIAM S WARD; Fiscal Year: 2013
    ..Without these elements, our published data suggest that the paternal DNA would never be replicated, and embryonic development would not be possible...
  36. Heparan Sulfate Proteoglycans in Human Hematopoiesis
    Pankaj Gupta; Fiscal Year: 2013
    ..an extracellular heparin-binding BMP inhibitor that plays a critical role in growth, differentiation and embryonic development and in various diseases...
  37. Small Molecule-Mediated Augmentation of Kidney Regeneration
    Neil A Hukriede; Fiscal Year: 2010
    ..We therefore hypothesized that any treatment that causes expansion of these progenitor cells during embryonic development would also accelerate the rate of recovery in AKI...
  38. Oocyte-derived R-spondin2 as a Follicle Stimulating Hormone
    AARON JW HSUEH; Fiscal Year: 2013
    ..We will evaluate epigenetic changes, mitochondrial integrity and early embryonic development of mature oocytes to insure the efficacy and safety of the present treatment regimen...
  39. Study DNA repair in preventing MDS and AML after radiation and benzene exposure
    EDWARD PAUL HASTY; Fiscal Year: 2013
    ..the impact these genotoxins have on a variety of bone marrow cells including HSCs and vulnerable times of exposure (embryonic development vs. adult). Thus, results from this proposal will elucidate the pathobiology of MDS/AML.
  40. The Role of DNMT3B in the DNA Methylation of Cancer Cells
    LUCY ANN GODLEY; Fiscal Year: 2012
    ..Furthermore, transgenic mice that express DNMT3B7 display disrupted embryonic development and changes in DNA methylation that are dependent on DNMT3B7 transgene levels...
  41. The role of the primitive choana in amniote craniofacial morphogenesis
    John Abramyan; Fiscal Year: 2013
    ..These will be the first studies on the embryonic development of the choanae...
  42. Transcriptional mechanisms of lower urinary tract development
    Gerald Mingin; Fiscal Year: 2013
    ..is characterized by a failure of the lower urinary and intestinal/rectal tracts to separate during embryonic development. To understand the cellular and molecular origins of these defects and to begin to shed light onto the ..
  43. Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes
    Russ B Hauser; Fiscal Year: 2013
    ..abstract_text> ..
  44. A Drosophila Model for Genetic Studies of Metabolism
    Carl S Thummel; Fiscal Year: 2010
    ..on our understanding of human health through the delineation of the fundamental pathways that dictate embryonic development and the discovery of central signaling pathways, such as Notch, Wnt, and hedgehog signaling...
    MAX ELLIOT GOTTESMAN; Fiscal Year: 2013
    ..2 diabetes; pancreatic islet development;the role(s) of transcriptional regulators and secreted factors in embryonic development;the regulation of the inflammatory response by diffusible molecules, particularly cytokines;several ..
  46. Investigation of the liver progenitor cell niche using CK19 lineage tracing
    EUGENE SCOTT SWENSON; Fiscal Year: 2011
    ..Marking of CK19+ populations during embryonic development is expected to mark all descendants of hepatoblasts, including hepatocytes and cholangiocytes...
  47. Control of embryonic development by CK2: CK2 as a core Wnt/beta-catenin component
    María Isabel Domínguez; Fiscal Year: 2013
    ..Wnt/b-catenin signaling is essential for embryonic development, for adult tissue homeostasis and is linked to human diseases and disorders such as sex reversal, ..
  48. Role of micro RNAs in renin cell differentiation
    ROBERTO ARIEL GOMEZ; Fiscal Year: 2013
    ..In early embryonic development, renin precursor cells are present in the undifferentiated metanephric mesenchyme...
  49. Analyses of two RNA helicases that affect intercellular transport via plasmodesma
    Patricia C Zambryski; Fiscal Year: 2012
    ..a unique genetic screen that assays for altered PD mediated cell-to-cell transport during Arabidopsis embryonic development. To date we have analyzed two mutants, ise1 and ise2, that cause embryos to increase PD mediated traffic ..
  50. Biochemical and Genetic Analysis of yFACT, A Novel Nucleosome Reorganizing Factor
    TIMOTHY G FORMOSA; Fiscal Year: 2013
    ..a wide range of systems biology studies seeking factors that regulate cellular physiology, promote normal embryonic development, and allow stem cells to maintain pluripotency...
  51. Understanding Wnt signaling through Ror and Ryk family receptor tyrosine kinases
    Mark A Lemmon; Fiscal Year: 2013
    ..Wnts are secreted ligands of approximately 330 amino acids that play key roles in embryonic development and control a spectrum of processes in the adult, ranging from organ regeneration to stem cell maintenance ..
  52. Lysophosphatidic Acid in Oncogenesis
    Xianjun Fang; Fiscal Year: 2010
    ..We recently disrupted the Ipa4 gene by targeted deletion in mice. Although the LPA4 is not required for embryonic development and fertility, we observed a dramatic increase in development of spontaneous tumors in Ipa4 mutant mice...
  53. Pituitary Development in a Novel Animal Model of Pediatric Hormone Deficiency
    KELLY PRINCE; Fiscal Year: 2012
    ..of this CPHD disease, pituitaries of W227Ter knock-in mouse embryos will be examined at multiple stages of embryonic development for expression of the characteristic anterior pituitary hormones, cellular differentiation markers, and ..
  54. The role of b-carotene in maternal-fetal nutrition
    Loredana Quadro; Fiscal Year: 2013
    ..These studies will ultimately expand our knowledge of maternal-fetal nutrition and dietary contribution to embryonic development, thus providing new insight into appropriate dietary practices during pregnancy...
  55. Insm1 in Development of Spiral and Vestibular Ganglia
    Sarah M Lorenzen; Fiscal Year: 2013
    ..ISH) to detect the expression of Insm1 in the developing ear at different time points during embryonic development. We will also use ISH followed by immunohistochemistry (IHC) for proliferation markers (Ph3, Ki67, and ..
    R Dyche Mullins; Fiscal Year: 2013
    ..engulf food while multi-cellular organisms rely on this type of migration for many processes including: embryonic development, remodeling of the nervous system, fighting off infection, and healing wounds...
  57. Control of Cardiac Lineage Commitment and Differentiation in Murine Development
    Ibrahim J Domian; Fiscal Year: 2013
    ..Determine the mechanisms by which miR200 controls FHF development;3) Determine the role of miR200 during embryonic development. The tools and understanding developed here will contribute to the scientific basis of cardiac ..
  58. Endocrine Disruptors: Assessment of endocrine disruption activity, mechanism and
    Subhrangsu Mandal; Fiscal Year: 2010
    ..EDC activity, we propose to utilize the promoter of estrogen responsive HOX genes that are key players in embryonic development. Recently, we found that estrogen (E2) transcriptionally regulates several HOX genes including HOXC13 and ..
  59. Regulation and function of Six1 in zebrafish muscle development and in rhabdomyos
    JENEAN O'BRIEN; Fiscal Year: 2013
    ..Six1 expression is normally limited to early embryonic development, where its promotion of precursor cell activation and migration contribute to proper formation of muscle, ..
  60. Wnt Signaling in Hematopoietic Stem Cell Specification and Leukemia
    ..approach to defining required regulatory networks is to determine the endogenous mechanisms used during embryonic development. Often, involved signal transduction pathways are also observed to be dysregulated in leukemia, making an ..
  61. Mechanism of Gli3 processing in Hedgehog signaling
    Baolin Wang; Fiscal Year: 2013
    ..Dysfunction in Hh signaling results in abnormal embryonic development and several types of cancer in human;thus, understanding the molecular mechanisms of Hh signal ..
  62. Histone Deacetylases and Kidney Development
    Samir S El Dahr; Fiscal Year: 2010
    ..Histone acetylation plays important roles in cancer, immune disorders and embryonic development. In the mouse, targeted inactivation of HDAC1 and HDAC2 genes causes embryonic lethality precluding the ..
  63. Quantitative Analysis of Chemotactic Motility Cycle of Ameboid Cells
    JUAN CARLOS LASHERAS; Fiscal Year: 2013
    ..provided by applicant): Eukaryotic cell motility is essential for many physiological processes such as embryonic development, tissue renewal, and the function of the immune system...
  64. A Neural Development mRNA Decay Network
    Michael Cleary; Fiscal Year: 2013
    ..The study of mRNA decay during embryonic development has previously been hindered by the lack of methods allowing in vivo, cell type-specific measurements of ..
  65. Mechanisms of Metal Ion Regulation in Human Cells
    Svetlana Lutsenko; Fiscal Year: 2013
    ..Copper is an essential nutrient required for embryonic development, connective tissue formation, myelination of neurons, detoxification of radicals, and many other ..
  66. Transcriptional regulation of neuronal differentiation
    Bennett G Novitch; Fiscal Year: 2013
    ..investigate the genetic pathways that regulate the formation of motor neurons in the spinal cord during embryonic development. We have recently found that members of the Foxp transcription factor family are progressively expressed ..
  67. Oocyte polarity and mRNA localization in Zebrafish
    FLORENCE LOUISE MARLOW; Fiscal Year: 2013
    ..An improved understanding of the essential maternal genes regulating early embryonic development in zebrafish will provide insight into the basis of birth defects and miscarriage, and facilitate ..
  68. polr1c and polr1d mutant zebrafish as new models for Treacher Collins syndrome
    KRISTIN EMILY NOACK WATT; Fiscal Year: 2013
    ..In Aim 1 of this proposal, we will determine the role of polr1c and polr1d during embryonic development in order to investigate the mechanisms underlying the pathogenesis of TCS and identify new avenues for ..
  69. Epha/Ephrin - A Signaling in Epidermal Differentiation and Disease
    Spiro Getsios; Fiscal Year: 2013
    ..This large family of receptor tyrosine kinases plays a key role in embryonic development and cancer progression but has not been thoroughly investigated in normal adult epithelial tissues, ..
  70. BMP-2 Regulation of Bone Homeostasis
    Vicki Rosen; Fiscal Year: 2013
    ..Removal of individual osteogenic BMPs (BMPs 2, 4, 5, 6, 7) during embryonic development shows that loss of any individual BMP can be compensated for by the other BMPs present...
  71. Environmental toxins and stem cell epigenetic remodeling
    Joyce Ellen Ohm; Fiscal Year: 2013
    ..It is also hypothesized that the dynamic nature of epigenetic remodeling during embryonic development may leave cells particularly vulnerable to the effects of environmental toxins...
  72. Deleted in liver cancer 1 (DLC1) in liver development and disease
    Yi Ping Shih; Fiscal Year: 2013
    ..Knockout mouse studies have indicated an essential role for DLC1 in mouse embryonic development as homozygous mutant embryos die before 10.5 days...
  73. Signaling pathways that mediate mammalian oocyte cortical mechanics
    Douglas N Robinson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Successful embryonic development is dependent on the female gamete progressing correctly through its meiotic divisions, with the first division occurring during oocyte maturation and the second ..
  74. Osteoblast and Odontoblast Specific Regulatory Action of Runx2 for Bone and Tooth
    MITRA D ADHAMI; Fiscal Year: 2013
    ..However, it is known that gene expression of Runx2 increases throughout embryonic development, and Runx2 maintains high expression in postnatal development...
  75. Mechanisms of X Chromosome Silencing and Its Relation to Pluripotency
    Amy Pandya-Jones; Fiscal Year: 2013
    ..in this proposal is aimed at understanding how a non-coding RNA molecule initiates extensive epigenetic changes that are critical to normal embryonic development and how these processes are related to the pluripotent state of the cell.
    Thomas D Pollard; Fiscal Year: 2013
    ..Cellular movements are essential for cell division, embryonic development and defense against microorganisms...
  77. Uncovering mechanisms controlling notochord vacuole and spine morphogenesis
    Michel Bagnat; Fiscal Year: 2013
    ..We established that notochord vacuoles are required for antero-posterior (AP) axis elongation during embryonic development and identified a novel role for this fluid filled organelle in spine morphogenesis...
    Christopher A Walsh; Fiscal Year: 2013
    ..The pace and nature of neurogenesis changes rapidly in the last days of embryonic development suggesting that global cues change as well...
  79. Erk-mediated regulation of Dicer and Drosha function in C. elegans
    Swathi Arur; Fiscal Year: 2013
    ..Similarly, in C. elegans and mice, loss of Dicer or Drosha disrupts oocyte meiotic maturation and embryonic development, respectively...
  80. Methods Development for CVM Cell Migration Study in Drosophila
    ANGELIKE M STATHOPOULOS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cell migration is a very influential process during embryonic development as it results in rearrangement of cells from one area of the embryo to another, effectively controlling cell-cell ..
  81. PKD Isoforms in Heart
    Susan F Steinberg; Fiscal Year: 2013
    ..manner in cardiomyocytes, and PKDs have both overlapping and non-redundant roles in mouse embryonic development and adult heart hypertrophy provide the rationale for the aims of this application...
  82. Targeted genome modification of guinea pig and sheep using engineered zinc finger
    Hilda Holcombe; Fiscal Year: 2012
    ..generate 1) guinea pigs deficient in one or more genes involved in the generation of immune responses and 2) sheep deficient in one or more genes involved in embryonic development of the cardiac and respiratory systems.
  83. Molecular Mechanism of Hepatocyte Growth Factor Signaling
    Po Han Chen; Fiscal Year: 2013
    ..In human, HGF and MET play pivotal roles in embryonic development, morphogenesis, tissue repair, and progression of malignancy...
  84. Development of an Epigenetic Biomarker for Prediction of Fetal Alcohol Spectrum D
    AILEEN ESTELLE BALDWIN; Fiscal Year: 2013
    ..DNA methylation patterns of genes known to play important roles in development and contribute to abnormal embryonic development, suggesting that alcohol-associated alterations in DNA methylation profiles, identified from neonatal ..
  85. Transcriptional Regulation of Motor Neuron Subtype Development
    MADALYNN LEA ERB; Fiscal Year: 2013
    ..During embryonic development, motor neuron circuits are formed through the generation of multiple motor neuron subtypes, which each ..
  86. Encoding Long Term Stability of Neuronal Function
    Bruno Marie; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): During embryonic development, transcription factors are essential for establishing a code that will determine the fate of neuronal precursors and neurons...
  87. Development of sEphB4-HSA as Novel Therapeutic in Cancer
    VALERY G KRASNOPEROV; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): During embryonic development, EphB4 and EphrinB2 are both critically required for maturation of newly forming blood vessels. EphrinB2 and is critically required for activation of VEGFR2/3...
  88. The effects of organophosphates on anxiety-related behavior and neurodevelopment
    Holly Richendrfer; Fiscal Year: 2013
    ..the neurobehavioral and neurodevelopmental impact of low levels of organophosphate pesticides during early embryonic development. Until more is known about the detrimental effects of early exposure to organophosphates, adherence to ..
  89. Maternal epigenetic dietary effects on early breast cancer prevention
    PHILLIP JOE BUCKHAULTS; Fiscal Year: 2013
    ..activation/silencing expression, and epigenetic control is believed to play a key role in regulating early embryonic development. Dietary components with properties in influencing epigenetic processes are believed to have effects on ..
    Matthew D Welch; Fiscal Year: 2013
    ..These processes are important for normal embryonic development, immune system function and tissue repair, and also contribute to illnesses such cardiovascular disease, ..
  91. Does Arsenic Target Border Specific Cells during Embryogenesis?
    Lisa J Bain; Fiscal Year: 2013
    ..Exposure during embryonic development is associated with low birth weight, altered locomotor activity, and reduced neuronal development, likely ..
  92. Genetic and chemical screening in zebrafish to study tendon development
    Jenna L Galloway; Fiscal Year: 2013
    ..how essential these tissues are for mobility, we know very little about their molecular regulation during embryonic development. The goal of this project is to discover the pathways regulating tendon and ligament formation and ..
  93. Center for Mammalian Regulatory Genomics
    Bing Ren; Fiscal Year: 2013
    ..In addition to embryonic development, our studies will also generate a complementary reference dataset from postnatal and adult mice to better ..
  94. Control and function of the yeast RAM network
    ERIC LYLE WEISS; Fiscal Year: 2013
    ..This control is fundamental to embryonic development and tissue function;its derangement is an important aspect of numerous human diseases...
  95. Biomechanics of early mammalian cardiogenesis
    Irina Larina; Fiscal Year: 2013
    ..this complex, dynamic process by direct visualization and analysis of the heartbeat and blood flow during embryonic development using the live OCT mouse embryo imaging approach which we developed...
  96. Spatiotemporal Modulation of PIP[3]Signaling in Prostatic Tubulogenesis
    Tamara L Lotan; Fiscal Year: 2013
    ..There is increasing evidence that many of the signaling pathways that regulate prostatic growth during embryonic development are reactivated in adult diseases, such as benign prostatic hyperplasia and cancer...
  97. Grhl2-regulation of Developing Ectoderm as a Model to Identify Suppressors of EMT
    Heather Ray; Fiscal Year: 2013
    ..provided by applicant): The epithelial-to-mesenchymal (EMT) transition plays an essential role during embryonic development. Studies have also found that EMT can be involved in the promotion of various epithelial cancers...
  98. Regulation of Adult Tendon Growth and Regeneration by Scleraxis
    Christopher L Mendias; Fiscal Year: 2013
    ..Scleraxis is a bHLH transcription factor that is critical for the embryonic development of limb tendons, but little is known about scleraxis function in adult tendons...
  99. RXRalpha and PPARdelta Signaling as Novel Regulators of the Blood-Brain Barrier
    Eric V Shusta; Fiscal Year: 2013
    ..The BBB begins to form early in embryonic development as the mesoderm-derived vasculature invades the immature central nervous system (CNS) and begins to gain ..
  100. Mechanisms of pancreatic endocrine cell differentiation
    Maike Sander; Fiscal Year: 2013
    ..has determined that ductal progenitors in the pancreas are the major source of endocrine cells during embryonic development. Mechanistic studies in the PI's laboratory have further shown that the transcription factor Sox9 is ..
  101. Mechanisms of Contact-Mediated Cell Polarization in the C. elegans Embryo.
    JEREMY FRANKLIN NANCE; Fiscal Year: 2013
    ..into the fundamental mechanisms of cell polarization, and specific molecular insights into how cell contacts polarize human blastomeres and epithelial cells to promote embryonic development and inhibit tumorigenesis