embryonic and fetal development

Summary

Summary: Morphological and physiological development of EMBRYOS or FETUSES.

Top Publications

  1. ncbi Effects of different reproduction techniques: AI MOET or IVP, on health and welfare of bovine offspring
    A M van Wagtendonk-de Leeuw
    Holland Genetics, R and D, Arnhem, The Netherlands
    Theriogenology 53:575-97. 2000
  2. pmc E-cadherin null mutant embryos fail to form a trophectoderm epithelium
    L Larue
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Proc Natl Acad Sci U S A 91:8263-7. 1994
  3. ncbi Viable offspring derived from fetal and adult mammalian cells
    I Wilmut
    Roslin Institute Edinburgh, Roslin, Midlothian, UK
    Nature 385:810-3. 1997
  4. pmc Regulation of programmed cell death by basement membranes in embryonic development
    P Murray
    Department of Human Anatomy and Cell Biology, The University of Liverpool, Liverpool L69 3GE, United Kingdom
    J Cell Biol 150:1215-21. 2000
  5. ncbi Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2
    Y Yokota
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Nature 397:702-6. 1999
  6. ncbi Production of cloned calves following nuclear transfer with cultured adult mural granulosa cells
    D N Wells
    AgResearch, Ruakura Research Centre, PB 3123, Hamilton, New Zealand
    Biol Reprod 60:996-1005. 1999
  7. ncbi Nuclear cloning and epigenetic reprogramming of the genome
    W M Rideout
    Whitehead Institute for Biomedical Research and, Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 293:1093-8. 2001
  8. pmc Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos
    W Dean
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Program, Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Proc Natl Acad Sci U S A 98:13734-8. 2001
  9. ncbi Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
    G Winnier
    Howard Hughes Medical Institute, Vanderbilt University Medical School, Nashville, Tennessee 37232 2175, USA
    Genes Dev 9:2105-16. 1995
  10. ncbi Embryonic heart and skin defects in mice lacking plakoglobin
    C Bierkamp
    Department of Molecular Embryology, Max Planck Institute for Immunobiology, Stubeweg 51, Freiburg, D 79108, Germany
    Dev Biol 180:780-5. 1996

Detail Information

Publications217 found, 100 shown here

  1. ncbi Effects of different reproduction techniques: AI MOET or IVP, on health and welfare of bovine offspring
    A M van Wagtendonk-de Leeuw
    Holland Genetics, R and D, Arnhem, The Netherlands
    Theriogenology 53:575-97. 2000
    ..From Study 2 it can be concluded that using a semi-defined medium for in vitro culture (SOF) may improve characteristics of IVP calves born...
  2. pmc E-cadherin null mutant embryos fail to form a trophectoderm epithelium
    L Larue
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Proc Natl Acad Sci U S A 91:8263-7. 1994
    ..These results demonstrate the pivotal role of E-cadherin in one of the most basic morphogenetic events in the development of multicellular organisms, the biogenesis of an epithelium...
  3. ncbi Viable offspring derived from fetal and adult mammalian cells
    I Wilmut
    Roslin Institute Edinburgh, Roslin, Midlothian, UK
    Nature 385:810-3. 1997
    ....
  4. pmc Regulation of programmed cell death by basement membranes in embryonic development
    P Murray
    Department of Human Anatomy and Cell Biology, The University of Liverpool, Liverpool L69 3GE, United Kingdom
    J Cell Biol 150:1215-21. 2000
    ..We conclude that the BM not only directly regulates development of epiblast epithelial cells, but also indirectly regulates the programmed cell death necessary for cavity formation...
  5. ncbi Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2
    Y Yokota
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Nature 397:702-6. 1999
    ..Our results indicate that Id2 has an essential role in the generation of peripheral lymphoid organs and NK cells...
  6. ncbi Production of cloned calves following nuclear transfer with cultured adult mural granulosa cells
    D N Wells
    AgResearch, Ruakura Research Centre, PB 3123, Hamilton, New Zealand
    Biol Reprod 60:996-1005. 1999
    ..The next advance in this technology will be to introduce specific genetic modifications of biomedical or agricultural interest...
  7. ncbi Nuclear cloning and epigenetic reprogramming of the genome
    W M Rideout
    Whitehead Institute for Biomedical Research and, Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 293:1093-8. 2001
    ....
  8. pmc Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos
    W Dean
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Program, Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Proc Natl Acad Sci U S A 98:13734-8. 2001
    ..Our study shows that epigenetic reprogramming occurs aberrantly in most cloned embryos; incomplete reprogramming may contribute to the low efficiency of cloning...
  9. ncbi Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
    G Winnier
    Howard Hughes Medical Institute, Vanderbilt University Medical School, Nashville, Tennessee 37232 2175, USA
    Genes Dev 9:2105-16. 1995
    ..Moreover, in the presumed absence of zygotic ligand, it appears that homozygous mutants can be rescued partially by related proteins or by maternal BMP-4...
  10. ncbi Embryonic heart and skin defects in mice lacking plakoglobin
    C Bierkamp
    Department of Molecular Embryology, Max Planck Institute for Immunobiology, Stubeweg 51, Freiburg, D 79108, Germany
    Dev Biol 180:780-5. 1996
    ..The skin phenotype in plakoglobin-deficient mice is reminiscent of the human blistering disease, epidermolytic hyperkeratosis...
  11. pmc JunB is essential for mammalian placentation
    M Schorpp-Kistner
    Deutsches Krebsforschungszentrum Heidelberg, Abteilung für Signaltransduktion und Wachstumskontrolle, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    EMBO J 18:934-48. 1999
    ..Therefore, JunB appears to be involved in multiple signaling pathways regulating genes involved in the establishment of a proper feto-maternal circulatory system...
  12. ncbi The effects of antibodies to heat shock protein 70 in fertilization and embryo development
    C Matwee
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada
    Mol Hum Reprod 7:829-37. 2001
    ..We propose that HSP70 plays a critical role in fertilization and early embryonic development...
  13. ncbi Apoptosis and cell proliferation potential of bovine embryos stimulated with insulin-like growth factor I during in vitro maturation and culture
    A V Makarevich
    Agrifood Research Finland, Animal Production Research, FIN 31600 Jokioinen, Finland
    Biol Reprod 66:386-92. 2002
    ..Our data suggest that an assay for TUNEL in conjunction with cell proliferation analysis can provide useful information about the quality of IVP embryos...
  14. ncbi Development rates of male bovine nuclear transfer embryos derived from adult and fetal cells
    J R Hill
    Department of Veterinary Physiology and Pharmacology, Department of Large Animal Medicine and Surgery, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 62:1135-40. 2000
    ..Serum starvation of these adult donor cells did not improve development rates of NT embryos to blastocyst, but when fetal cells were serum-starved, there was a significant increase in development to blastocyst...
  15. ncbi Production of male cloned mice from fresh, cultured, and cryopreserved immature Sertoli cells
    A Ogura
    Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    Biol Reprod 62:1579-84. 2000
    ..This study demonstrates that immature Sertoli cells, male-specific somatic cells, are potential donors for somatic cell cloning...
  16. ncbi Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo
    W R Waldrip
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Cell 92:797-808. 1998
    ..Chimera experiments demonstrate these essential activities are contributed by the extraembryonic tissues. Thus, the extraembryonic tissues play critical roles in establishing the body plan during early mouse development...
  17. pmc Disruption of the MacMARCKS gene prevents cranial neural tube closure and results in anencephaly
    J Chen
    The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 93:6275-9. 1996
    ....
  18. pmc Placental failure in mice lacking the mammalian homolog of glial cells missing, GCMa
    J Schreiber
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, D 20246 Hamburg, Germany
    Mol Cell Biol 20:2466-74. 2000
    ..Our results indicate that mGCMa plays a critical role in trophoblast differentiation and the signal transduction processes required for normal vascularization of the placenta...
  19. ncbi Coordination between donor cell type and cell cycle stage improves nuclear cloning efficiency in cattle
    D N Wells
    Reproductive Technologies, AgResearch Ltd, Ruakura Research Centre, East Street, Private Bag 3123, Hamilton, New Zealand
    Theriogenology 59:45-59. 2003
    ..This suggests that it may be necessary to coordinate donor cell type and cell cycle stage to maximize overall cloning efficiency...
  20. pmc Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse
    Josiane Menissier de Murcia
    Unité 9003 du CNRS, Ecole Superieure de Biotechnologie de Strasbourg, Boulevard Sebastien Brant, BP 10413, 67412 Illkirch Cedex, France
    EMBO J 22:2255-63. 2003
    ..Together, these results support the notion that PARP-1 and PARP-2 possess both overlapping and non-redundant functions in the maintenance of genomic stability...
  21. ncbi A cell autonomous function of Brachyury in T/T embryonic stem cell chimaeras
    P Rashbass
    AFRC Centre for Genome Research, Edinburgh, UK
    Nature 353:348-51. 1991
    ..The results indicate that the T gene acts cell autonomously in the primitive streak and notochord but may activate a signalling pathway involved in the specification of other mesodermal tissues...
  22. ncbi Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice
    A Naito
    Department of Oncology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Genes Cells 4:353-62. 1999
    ..However, the functions of TRAF6 in vivo remain unidentified...
  23. ncbi OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    Y Y Kong
    Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Nature 397:315-23. 1999
    ..Thus OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo...
  24. ncbi The role of essential trace elements in embryonic and fetal development in livestock
    Chris E Hostetler
    Department of Animal Sciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA
    Vet J 166:125-39. 2003
    ....
  25. ncbi Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-alpha-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis
    M Matsumoto
    First Department of Internal Medicine, School of Medicine, Ehime University, Japan
    J Immunol 163:1584-91. 1999
    ....
  26. ncbi Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice
    C van Genderen
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0414
    Genes Dev 8:2691-703. 1994
    ..Together, the pattern of these defects suggest an essential role for LEF-1 in the formation of several organs and structures that require inductive tissue interactions...
  27. pmc An alpha-E-catenin gene trap mutation defines its function in preimplantation development
    M Torres
    Abteilung Molekulare Zellbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Proc Natl Acad Sci U S A 94:901-6. 1997
    ....
  28. ncbi An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis
    L De Moerlooze
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 127:483-92. 2000
    ..Our findings point to a key role for fibroblast growth factor receptor 2(IIIb) in mesenchymal-epithelial signalling during early organogenesis...
  29. ncbi Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4(-/-) embryos
    S A Duncan
    Laboratory of Molecular Cell Biology, The Rockefeller University, New York, New York 10021, USA
    Development 124:279-87. 1997
    ..Furthermore, specific complementation of Hnf-4(-/-) embryos with tetraploid-derived Hnf-4(+/+) VE rescues their early developmental arrest, showing conclusively that a functional VE is mandatory for gastrulation...
  30. ncbi Pig cloning by microinjection of fetal fibroblast nuclei
    A Onishi
    Department of Animal Breeding and Genetics, National Institute of Animal Industry, Tsukuba Norin Danchi, Ibaraki ken 305 0901, Japan
    Science 289:1188-90. 2000
    ..The transfer of 110 cloned embryos to four surrogate mothers produced an apparently normal female piglet. The clonal provenance of the piglet was indicated by her coat color and confirmed by DNA microsatellite analysis...
  31. ncbi Apparent lability of neural tube closure in laboratory animals and humans
    J M DeSesso
    Biomedical Research Institute, Mitretek Systems, McLean, Virginia 22102, USA
    Am J Med Genet 87:143-62. 1999
    ..We further conclude that, because of both the relatively high prevalence and the multifactorial nature of NTDs, the mere occurrence of an NTD is insufficient for inferring that the defect was caused by an exogenous agent...
  32. ncbi Anti-apoptotic action of insulin-like growth factor-I during human preimplantation embryo development
    S Spanos
    Department of Reproductive Science and Medicine, Division of Paediatrics, Obstetrics and Gynaecology, Imperial College School of Medicine, Hammersmith Hospital, London, W12 ONN, United Kingdom
    Biol Reprod 63:1413-20. 2000
    ..1 without IGF-I). The increased number of blastocysts combined with reduced cell death suggests that IGF-I is rescuing embryos in vitro which would otherwise arrest and acting as a survival factor during preimplantation human development...
  33. ncbi Rescuing the N-cadherin knockout by cardiac-specific expression of N- or E-cadherin
    Y Luo
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 128:459-69. 2001
    ....
  34. ncbi Multiple sites of Hox-7 expression during mouse embryogenesis: comparison with retinoic acid receptor mRNA localization
    G E Lyons
    Department of Molecular Biology, U A CNRS 1148, Institut Pasteur, Paris, France
    Mol Reprod Dev 32:303-14. 1992
    We report results from a study of Hox-7 expression during mouse embryonic and fetal development and compare the localization of Hox-7 transcripts with those of the retinoic acid receptors...
  35. pmc Expression and in vitro function of beta 1-integrin laminin receptors in the developing avian ciliary ganglion
    C D Weaver
    Department of Physiology, University of California at San Francisco 94143, USA
    J Neurosci 15:5275-85. 1995
    ..Taken together, these data suggest that interactions of cell surface alpha 3 beta 1 and alpha 6 beta 1 integrins with laminin-1 are likely to mediate growth of CG neurons during pathfinding in vivo...
  36. pmc Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development
    J Lee
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109 0606, USA
    Proc Natl Acad Sci U S A 98:6842-7. 2001
    ..These results demonstrate a crucial role for Cu acquisition through the Ctr1 transporter for mammalian Cu homeostasis and embryonic development...
  37. ncbi Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis
    N Dewulf
    Laboratory of Molecular Biology Celgen, University of Leuven, Belgium
    Endocrinology 136:2652-63. 1995
    ..In addition, the expression of these genes in many soft tissues suggests broader functions for BMPs in embryogenesis...
  38. ncbi The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues
    A Fütterer
    Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Germany
    Immunity 9:59-70. 1998
    ..Thus, the LTbetaR proves pivotal for the ontogeny of the secondary lymphoid tissues. Furthermore, affinity maturation is dependent on LTalpha1beta2 rather than on LTalpha3...
  39. ncbi Delayed and incomplete reprogramming of chromosome methylation patterns in bovine cloned embryos
    D Le Bourhis
    , , , 75743 Paris Cedex 15, France
    Curr Biol 11:1542-6. 2001
    ....
  40. ncbi Distribution of the ten known laminin chains in the pathways and targets of developing sensory axons
    S I Lentz
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 378:547-61. 1997
    ..g., gamma 1), continue to be expressed by Schwann cells into adulthood. In contrast to peripheral nerves and ganglia, laminin chains are expressed at low levels, if at all, in the developing spinal cord gray matter...
  41. pmc Expression of endothelin 3 by mesenchymal cells of embryonic mouse caecum
    M A Leibl
    Department of Human Anatomy and Cell Biology, The University of Liverpool, Ashton Street, Liverpool L69 3GE, UK
    Gut 44:246-52. 1999
    ..However, details of EDN3 expression during embryogenesis are lacking, and consequently the cellular mechanism by which EDN3 regulates innervation of the terminal gut is unclear...
  42. ncbi Action of the Brachyury gene in mouse embryogenesis
    B G Herrmann
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Biochemie, Tubingen, Germany
    Ciba Found Symp 165:78-86; discussion 86-91. 1992
    ..Recent results suggest that the T gene encodes a nuclear factor involved in establishing notochord cell identity and differentiation, and is directly or indirectly involved in the organization of axial development...
  43. ncbi Expression pattern of the mouse T gene and its role in mesoderm formation
    D G Wilkinson
    Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, London, UK
    Nature 343:657-9. 1990
    ..This expression pattern correlates with the tissues affected in the T-gene mutant, and indicates that the T gene has a direct role in the early events of mesoderm formation and in the morphogenesis of the notochord...
  44. pmc Maternal IL-11Ralpha function is required for normal decidua and fetoplacental development in mice
    P Bilinski
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, 40225 Dusseldorf, Germany
    Genes Dev 12:2234-43. 1998
    ..Therefore, IL-11Ralpha signaling at the implantation site appears to be required for decidua development...
  45. ncbi Heart defects in connexin43-deficient mice
    J Ya
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, The Netherlands
    Circ Res 82:360-6. 1998
    ....
  46. ncbi Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus
    D D Spyropoulos
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112
    Genes Dev 8:1949-61. 1994
    ..In situ hybridization analysis demonstrates evx1 gene expression within the visceral endoderm after implantation and prior to gastrulation, at a time in which the mutant phenotype is first detected...
  47. ncbi Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects
    H Chang
    Departments of Pathology, Cell Biology and Molecular and Human Genetics, and Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA
    Development 126:1631-42. 1999
    ..Despite the expression of Smad5 from gastrulation onwards, and in contrast to knockouts of Smad2 and Smad4, Smad5 only becomes essential later in extraembryonic and embryonic development...
  48. ncbi Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop
    B R Stanton
    Molecular Embryology Section, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201
    Genes Dev 6:2235-47. 1992
    ..Examination of c-myc expression in mutant embryos indicates the existence of coordinate regulation of myc genes during mouse embryogenesis...
  49. ncbi A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice
    A C Davis
    Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030
    Genes Dev 7:671-82. 1993
    ..c-Myc protein is necessary for embryonic survival beyond 10.5 days of gestation; however, it appears to be dispensable for cell division both in ES cell lines and in the embryo before that time...
  50. pmc GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo
    E E Morrisey
    Department of Medicine, University of Chicago, Chicago, Illinois 60637 USA
    Genes Dev 12:3579-90. 1998
    ..In addition, these data demonstrate that GATA6 is required for establishment of the endodermally derived bronchial epithelium...
  51. ncbi c-jun is essential for normal mouse development and hepatogenesis
    F Hilberg
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Nature 365:179-81. 1993
    ..Interestingly, c-jun-/- ES cells can participate efficiently in the development of all somatic cells in chimaeric mice except liver cells, further suggesting an essential function of c-Jun in hepatogenesis...
  52. ncbi Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis
    Y Mishina
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Genes Dev 9:3027-37. 1995
    ....
  53. ncbi Superovulation of female mice delays embryonic and fetal development
    I Van der Auwera
    Leuven University Fertility Center, University Hospital Gasthuisberg, Catholic University Leuven, Leuven, Belgium
    Hum Reprod 16:1237-43. 2001
    ..If this observation in mice can be extrapolated to humans, it may offer an explanation for the delay in embryonic development and the low birth weight observed after IVF...
  54. ncbi HNF-3 beta is essential for node and notochord formation in mouse development
    S L Ang
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cell 78:561-74. 1994
    ..HNF-3 beta is not required for the development of definitive endoderm cells, but foregut morphogenesis is severely affected in HNF-3 beta -/- embryos...
  55. ncbi Requirement for Lim1 in head-organizer function
    W Shawlot
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 374:425-30. 1995
    ..A partial secondary axis developed anteriorly in some mutant embryos. Lim1 is thus an essential regulator of the vertebrate head organizer...
  56. pmc A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development
    D Riethmacher
    Max Delbrueck Laboratorium, Max Planck Gesellschaft, Koeln, Germany
    Proc Natl Acad Sci U S A 92:855-9. 1995
    ..Thus, maternal E-cadherin suffices for initial compaction of the morula but not for further preimplantation development to occur...
  57. ncbi Altered synthesis of laminin 1 and absence of basement membrane component deposition in (beta)1 integrin-deficient embryoid bodies
    M Aumailley
    Institute II for Biochemistry, University of Cologne, Germany
    J Cell Sci 113:259-68. 2000
    ....
  58. pmc Bmp4 is required for the generation of primordial germ cells in the mouse embryo
    K A Lawson
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, 3584 CT Utrecht, The Netherlands
    Genes Dev 13:424-36. 1999
    ..The initiation of the germ line in the mouse therefore depends on a secreted signal from the previously segregated, extraembryonic, trophectoderm lineage...
  59. ncbi Culture of preimplantation embryos and its long-term effects on gene expression and phenotype
    S Khosla
    Programme in Developmental Genetics, The Babraham Institute, Cambridge, UK
    Hum Reprod Update 7:419-27. 2001
    ..Imprinted genes play key roles in the control of fetal growth, and altered imprinting can cause growth defects. Some recent in-vitro culture studies on mice and ruminant species now lend support to this hypothesis...
  60. ncbi Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, Italy
    Development 125:5091-104. 1998
    ..Moreover, our data lead us to hypothesize that the differential post-transcriptional control existing between VE and epiblast cells may potentially contribute to fundamental regulatory mechanisms required for head specification...
  61. pmc Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation
    K Eggan
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 98:6209-14. 2001
    ..In addition, our results demonstrate that tetraploid embryo complementation using F(1) ES cells represents a simple, efficient procedure for deriving animals with complex genetic alterations without the need for a chimeric intermediate...
  62. ncbi Pesticide exposure and birthweight: an epidemiological study in Central Poland
    Sławomir Dabrowski
    Department of Obstetrics and Gynecology, District Hospital, Radomsko, Poland
    Int J Occup Med Environ Health 16:31-9. 2003
    ..A slower pace of fetal development, corresponding to the small-for-gestational-age effect, was observed, but the increment in the risk was of borderline significance...
  63. ncbi Nuclear translocation of nuclear factor kappa B in early 1-cell mouse embryos
    A Nishikimi
    Laboratory of Reproductive Physiology, Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Biol Reprod 60:1536-41. 1999
    ..Taken together, the results suggest that the activation of NF-kappaB at the early 1-cell stage is required for the development of mouse embryos beyond the 2-cell stage...
  64. ncbi Influence of in vitro systems on embryo survival and fetal development in cattle
    P W Farin
    Department of Farm Animal Health and Resource Management, North Carolina State University, Raleigh, NC, USA
    Theriogenology 55:151-70. 2001
    ..An understanding of how in vitro oocyte maturation, in vitro fertilization, and embryo culture systems influence both fetal and placental development should result in systems that consistently produce normal embryos, fetuses, and calves...
  65. pmc Contemporary-use pesticides in personal air samples during pregnancy and blood samples at delivery among urban minority mothers and newborns
    Robin M Whyatt
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 111:749-56. 2003
    ..Findings indicate that pesticide exposures are frequent but decreasing and that the pesticides are readily transferred to the developing fetus during pregnancy...
  66. ncbi Submandibular gland morphogenesis: stage-specific expression of TGF-alpha/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations
    T Jaskoll
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, California, 90089, USA
    Anat Rec 256:252-68. 1999
    ..These and other findings provide insight into the design of future functional studies...
  67. pmc Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality
    T S Doi
    Laboratory of Immunology, Aichi Cancer Center Research Institute, Nagoya 464, Japan
    Proc Natl Acad Sci U S A 96:2994-9. 1999
    ..Thus, the RelA-mediated antiapoptotic signal that protects normal cells from TNF injury in vitro can be shown to be operative in vivo...
  68. pmc neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    G Gradwohl
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, F 67404 Illkirch, France
    Proc Natl Acad Sci U S A 97:1607-11. 2000
    ..Thus, ngn3 is required for the specification of a common precursor for the four pancreatic endocrine cell types...
  69. pmc Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero
    Subrahmanyam S Chirala
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:6358-63. 2003
    ..These observations are very important in considering teratogenic consequences of drugs aimed at inhibiting FAS activity, to reduce either obesity or the growth of cancerous tissues...
  70. pmc Zic2 regulates the kinetics of neurulation
    T Nagai
    Molecular Neurobiology Laboratory, Tsukuba Life Science Center, RIKEN, Tsukuba, Ibaraki 305 0074, Japan
    Proc Natl Acad Sci U S A 97:1618-23. 2000
    ..Because the Zic2 knockdown mouse is the first mutant with HPE and spina bifida to survive to the perinatal period, the mouse will promote analyses of not only the neurulation but also the pathogenesis of human HPE...
  71. ncbi Epigenetic characteristics and development of embryos cloned from donor cells treated by trichostatin A or 5-aza-2'-deoxycytidine
    B P Enright
    Department of Animal Science Center for Regenerative Biology, University of Connecticut, Storrs, Connecticut 06269, USA
    Biol Reprod 69:896-901. 2003
    ..1% vs. 25.1%). These results indicate that partial erasure of preexisting epigenetic marks of donor cells improves subsequent in vitro development of cloned embryos...
  72. pmc Barx2, a new homeobox gene of the Bar class, is expressed in neural and craniofacial structures during development
    F S Jones
    Department of Neurobiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 94:2632-7. 1997
    ..The localization data, combined with Barx2's dual function as activator and repressor, suggest that Barx2 may differentially control the expression of L1 and other target genes during embryonic development...
  73. ncbi Distribution of osteonectin mRNA and protein during human embryonic and fetal development
    S Mundlos
    Department of Pediatrics, Johannes Gutenberg University Mainz, Federal Republic of Germany
    J Histochem Cytochem 40:283-91. 1992
    We investigated the temporal and spatial distribution of osteonectin during human embryonic and fetal development, using in situ hybridization and immunohistochemistry...
  74. pmc The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
    C Sirard
    Amgen Institute, Toronto, Ontario M5G 2C1, Canada
    Genes Dev 12:107-19. 1998
    ..Rescued embryos show severe anterior truncations, indicating a second important role for Smad4 in anterior patterning during embryogenesis...
  75. ncbi Dystroglycan is essential for early embryonic development: disruption of Reichert's membrane in Dag1-null mice
    R A Williamson
    Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    Hum Mol Genet 6:831-41. 1997
    ..Furthermore, these results suggest that disruption of basement membrane organization might be a common feature of muscular dystrophies linked to the DGC...
  76. ncbi In vitro development of porcine nuclear transfer embryos constructed using fetal fibroblasts
    P J Verma
    BresaGen Limited, Adelaide, South Australia, Australia
    Mol Reprod Dev 57:262-9. 2000
    ..Seven recipients farrowed a total of 51 piglets. Microsatellite analysis revealed that none of these were derived from the nuclear transfer embryos transferred...
  77. ncbi The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation
    T Nagai
    Molecular Neurobiology Laboratory, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Dev Biol 182:299-313. 1997
    ..Furthermore, analysis of gene expression patterns in different mouse mutants indicated that Zic genes may act upstream of many known developmental regulatory genes...
  78. ncbi Isolation and characterization of a novel trophoblast-specific cDNA in the mouse
    K R Lescisin
    Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada
    Genes Dev 2:1639-46. 1988
    ..The role of the gene is not currently known, but the presence of a signal peptide suggests that it may be a secreted protein...
  79. ncbi Developmental potential and transgene expression of porcine nuclear transfer embryos using somatic cells
    D B Koo
    Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea
    Mol Reprod Dev 58:15-21. 2001
    ..We conclude that somatic cells expressing exogenous genes can be used as nuclei donors in the production of NT-mediated transgenic pig...
  80. ncbi Hoxa3 and pax1 regulate epithelial cell death and proliferation during thymus and parathyroid organogenesis
    D Su
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    Dev Biol 236:316-29. 2001
    ..Our results suggest that a Hoxa3-Pax1 genetic pathway is required for both epithelial cell growth and differentiation throughout thymus and parathyroid organogenesis...
  81. ncbi Development of bovine oocytes reconstructed with different donor somatic cells with or without serum starvation
    J K Cho
    Department of Theriogenology, College of Veterinary Medicine, Seoul National University, South Korea
    Theriogenology 57:1819-28. 2002
    ..3%). In conclusion, serum starvation is effective for improving preimplantation development of oocytes reconstructed with cumulus or ear fibroblast cells and it may positively influence on obtaining better pregnancy outcome...
  82. ncbi Developmental potential of mouse embryos reconstructed from metaphase embryonic stem cell nuclei
    Q Zhou
    , Institut National de la Recherche Agronomique, 78352 Jouy en Josas, France
    Biol Reprod 65:412-9. 2001
    ..9% of activated oocytes), the postimplantation development was characterized by a high and rapid mortality. Our data provide a clear situation to explore the long-lasting effects that can be induced by early reprogramming events...
  83. ncbi Routine addition of human insulin-like growth factor-I ligand could benefit clinical in-vitro fertilization culture
    A D Lighten
    Division of Paediatrics, Obstetrics and Gynaecology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Hum Reprod 13:3144-50. 1998
    ..These data suggest that human preimplantation development is enhanced by maternal IGF-I. Mimicking this in-vivo paracrine relationship may improve clinical in-vitro embryo culture and IVF pregnancy rates...
  84. ncbi Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse
    M T Dattani
    London Centre for Paediatric Endocrinology and Metabolism, Institute of Child Health, UK
    Nat Genet 19:125-33. 1998
    ..These data suggest an important role for Hesx1/HESX1 in forebrain, midline and pituitary development in mouse and human...
  85. ncbi 2001 Warkany lecture: to die or not to die, the role of apoptosis in normal and abnormal mammalian development
    Philip E Mirkes
    Birth Defects Research Laboratory, Division of Genetics and Development, Department of Pediatrics, University of Washington, Seattle 98195, USA
    Teratology 65:228-39. 2002
    ..Future research aimed at understanding this regulation should provide insight not only into the mechanism of teratogen-induced cell death but also the role of cell death in the genesis of birth defects...
  86. ncbi Murine FGFR-1 is required for early postimplantation growth and axial organization
    C X Deng
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115
    Genes Dev 8:3045-57. 1994
    ..Such abnormalities are unlikely to be caused by intrinsic blocks in mesodermal differentiation, as FGFR-1-deficient ES cell lines form teratomas consisting of many mesodermal cell types...
  87. pmc Requirement of the mouse I-mfa gene for placental development and skeletal patterning
    N Kraut
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, A3 025, PO Box 19024, Seattle, WA 98109 1024, USA
    EMBO J 17:6276-88. 1998
    ..Our results indicate that I-mfa plays an important role in trophoblast and chondrogenic differentiation by negatively regulating a subset of lineage-restricted bHLH proteins...
  88. ncbi Programmed cell death in the absence of c-Fos and c-Jun
    S Roffler-Tarlov
    Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
    Development 122:1-9. 1996
    ..Finally, the results show that programmed cell death can take place in embryos lacking both Fos and Jun...
  89. ncbi DNA hypomethylation of karyoplasts for bovine nuclear transplantation
    K L Jones
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas, USA
    Mol Reprod Dev 60:208-13. 2001
    ..Supplementation of the donor cell culture medium with 5-aza-CR was not beneficial for increasing blastocyst rate or establishing pregnancy after NT...
  90. ncbi Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects
    M Ishibashi
    Institute for Immunology, Kyoto University Faculty of Medicine, Japan
    Genes Dev 9:3136-48. 1995
    ..These results suggest that HES-1 normally controls the proper timing of neurogenesis and regulates neural tube morphogenesis...
  91. pmc Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite
    J A McMahon
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA amcmahon biosun harvar d edu
    Genes Dev 12:1438-52. 1998
    ..Together these data demonstrate that inhibition of BMP signaling by axially secreted Noggin is an important requirement for normal patterning of the vertebrate neural tube and somite...
  92. pmc Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart
    P Ruiz
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Cell Biol 135:215-25. 1996
    ....
  93. ncbi Mist1: a novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern
    C Lemercier
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Dev Biol 182:101-13. 1997
    ..These observations suggest that Mist1 may function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages...
  94. ncbi Vinculin knockout results in heart and brain defects during embryonic development
    W Xu
    The Burnham Institute, La Jolla, CA 92037, USA
    Development 125:327-37. 1998
    ....
  95. ncbi Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice
    P A Koni
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 6:491-500. 1997
    ....
  96. ncbi Developmental potential of mouse primordial germ cells
    Y Kato
    Wellcome CRC Institute of Cancer and Developmental Biology and Physiological Laboratory, Tennis Court Road, University of Cambridge, Cambridge CB2 1QR, UK
    Development 126:1823-32. 1999
    ..The evidence suggests that gametic imprints are essential for normal development, and that they can neither be initiated nor erased in mature oocytes; these properties are unique to the developing germ line...
  97. ncbi Stage of the estrous cycle at the time of pregnant mare's serum gonadotropin injection affects pre-implantation embryo development in vitro in the mouse
    Juan J Tarín
    Department of Animal Biology, University of Valencia, Burjassot, Valencia, Spain
    Mol Reprod Dev 62:312-9. 2002
    ..These data endorse previous studies suggesting that administration of gonadotropins in mice should be synchronized with the innate estrous cycle of females...
  98. ncbi Monozygotic twinning in rhesus monkeys by manipulation of in vitro-derived embryos
    Shoukhrat M Mitalipov
    Oregon Regional Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Biol Reprod 66:1449-55. 2002
    ..Neither pregnancy resulted in term birth of monozygotic twins, but our results are sufficiently encouraging to justify a large-scale twinning trial in the rhesus macaque...
  99. ncbi Effects of oocyte maturation regimen on the relative abundance of gene transcripts in bovine blastocysts derived in vitro or in vivo
    H M Knijn
    Department of Farm Animal Health, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 7, 3584 CL Utrecht, The Netherlands
    Reproduction 124:365-75. 2002
    ....
  100. ncbi Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development
    Heidi J Auman
    Department of Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06511, USA
    Development 129:2733-47. 2002
    ..By contrast, the presence of AP-2gamma in the extra-embryonic membranes is required for normal development of this compartment and also for survival of the mouse embryo...
  101. ncbi Caspase activity and expression of cell death genes during development of human preimplantation embryos
    S Spanos
    Department of Reproductive Science and Medicine, Institute of Reproductive and Developmental Biology, The Wolfson and Weston Research Centre for Family Health, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Reproduction 124:353-63. 2002
    ..As in other types of cell, human embryos express common molecular components of the apoptotic cascade, although apoptosis appears to be suppressed before compaction and differentiation...

Research Grants62

  1. DEVELOPMENTAL POTENTIAL - NOVEL FETAL LYMPHOID PRECURSOR
    Gordon Keller; Fiscal Year: 2002
    ..In the second aim, we will define the developmental origin of B/T/MAC precursor, track its fate in embryonic and fetal development. The outcome of these experiments will provide new information on the role of this precursor in fetal ..
  2. Effects of Hypoxia on Craniofacial Morphology and Molecular Signaling
    FRANCIS JOEL SMITH; Fiscal Year: 2011
    ..defects that at least partially arise from environmental stresses including the lack of oxygen during embryonic and fetal development, as well as for devising new therapies to reverse these malformations...
  3. Principles of Robust Developmental Patterning
    Frederic Y M Wan; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Were it not for the remarkable accuracy and reliability of embryonic and fetal development, birth defects would be far more common than they are...
  4. FETAL ALCOHOL SPECTRUM DISEASE IN LOW INCOME COUNTRIES
    Na Na; Fiscal Year: 2012
    The earliest stages of life are periods of great vulnerability to the adverse effects of alcohol. Embryonic and fetal development are characterized by rapid, but well-synchronized patterns of gene expression, including epigenetic ..
  5. FAS AND BC1-2 AND GRANULOSA CELL APOPTOSIS
    Nicholas Cataldo; Fiscal Year: 2000
    ..Research plan. During embryonic and fetal development, the number of oocytes in the human ovary increases until mid-gestation, after which it steadily ..
  6. FETAL ALCOHOL SYNDROME: GENETIC STUDIES IN ZEBRAFISH
    MICHAEL CARVAN; Fiscal Year: 2002
    ..long-range goal of this project is to elucidate the molecular mechanisms by which ethanol perturbs embryonic and fetal development and to identify genes that play a role in the sensitivity to ethanol-induced teratogenesis...
  7. EMBRYONIC BONE FORMATION DURING ALUMINUM TOXICITY
    CONRAD FIRLING; Fiscal Year: 1990
    ..Aluminum intoxication during embryonic and fetal development has been associated with gross skeletal abnormalities...
  8. Molecular Markers of Oocyte Quality and Competence
    Graham Jenkin; Fiscal Year: 2007
    ..the development of healthy offspring, and that low oocyte quality can lead to infertility, abnormal embryonic and fetal development and possibly long-term adult diseases and disorders in the offspring...
  9. INTERACTION OF PROTEINS WITH AD INHIBITOR OF TNF-ALPHA
    Marshall Horwitz; Fiscal Year: 2001
    ..elegans affects development. Control of cell death plays an important part in embryonic and fetal development, autoimmunity and cancer as well as other important human diseases...
  10. MATERNAL NUTRITION AND PREGNANCY OUTCOME
    Carl Keen; Fiscal Year: 1992
    ..interest in the idea that maternal nutritional status may be a critical factor for normal human embryonic and fetal development. For example, during the last few years there has been considerable controversy about the hypothesis ..
  11. Maternal obesity, intrauterine gene expression and breast cancer
    KARIN MICHELS; Fiscal Year: 2007
    ..Insulin-like growth factor (IGF)-II plays a major role in embryonic and fetal development and growth. IGF2 is an imprinted gene expressed only by the paternal allele...
  12. Hematopoietic potential of the epidermis
    Paul Simmons; Fiscal Year: 2004
    ..if not all somatic tissues and are responsible for the generation of tissues and organ systems during embryonic and fetal development and for their maintenance and repair in adult life...
  13. MOLECULAR PATHOLOGY OF VASCULAR INJURY
    Dario Altieri; Fiscal Year: 2003
    ..Expressed in embryonic and fetal development, survivin is undetectable' in quiescent normal tissues and becomes abundantly re-expressed in all ..
  14. The significance of an antenatal nuchal cord
    JAMES CLAPP; Fiscal Year: 2005
    ..The question is should the ancillary finding of an antenatal nuchal cord on ultrasound exam be a cause for clinical concern. This proposal will provide data that should answer the question. ..
  15. VULNERABILITY OF THE FETUS/INFANT TO PAH, PM2.5 AND ETS.
    Frederica Perera; Fiscal Year: 2004
    ....
  16. EXERCISE AND PREGNANCY
    JAMES CLAPP; Fiscal Year: 2005
    ..Evaluations (mothers and offspring) will include a lifestyle and medical questionnaire, a physical examination, a lipid profile, and assessment of body composition, fitness, cardiovascular function and insulin resistance. ..
  17. BIOMARKERS OF GENETIC DAMAGE AND ANTIOXIDANT
    Frederica Perera; Fiscal Year: 2001
    ..Once validated in this model population, these biomarkers would also have applicability in evaluating interventions in occupational cohorts and other populations highly exposed to carcinogens. ..
  18. FETAL NEUROBEHAVIORAL DEVELOPMENT & POSTNATAL CONTINUITY
    JANET DI PIETRO; Fiscal Year: 2007
    ..abstract_text> ..
  19. Spatial Relationships Between Neurons in the CNS
    BENJAMIN REESE; Fiscal Year: 2005
    ..abstract_text> ..
  20. Pre & Postdoctoral Training in Nutrition
    Carl Keen; Fiscal Year: 2005
    ..Throughout our training we work to ensure that our graduates have vision and adaptability to work in environments where the skills and views of health professionals trained in nutrition are in urgent demand. ..
  21. Two-Photon Microscopy for Biomedical Research
    BENJAMIN REESE; Fiscal Year: 2007
    ..Acquisition of this 2-photon microscope will therefore enhance the diverse efforts of a number of investigators at UCSB in pursuit of their NIH-funded research objectives. [unreadable] [unreadable] [unreadable]..
  22. Dispersion Patterns for Retinal Neuroblasts
    BENJAMIN REESE; Fiscal Year: 2009
    ..abstract_text> ..
  23. NUTRITIONAL FACTORS IN MAMMALIAN DEVELOPMENT
    Carl Keen; Fiscal Year: 2009
    ..abstract_text> ..
  24. OXIDATIVE STRESS, ANTIOXIDANT STATUS & PREGNANCY OUTCOME
    Theresa Scholl; Fiscal Year: 2005
    ....
  25. Influence of Dietary Flavonoids on the Expression of At*
    Carl Keen; Fiscal Year: 2002
    ..Finally, they will examine the effects of the diets on the activation of NFkB and cell signaling pathways. ..
  26. COPPER NUTRITION AND DEVELOPMENT
    Carl Keen; Fiscal Year: 2004
    ..This information should provide new insights into the mechanisms underlying copper deficient pathologies and may contribute to our understanding of this process during human development. ..
  27. ENHANCING IN VITRO PRODUCTION OF RARE EMBRYOS
    Rebecca Spindler; Fiscal Year: 2002
    ..abstract_text> ..
  28. INTRAUTERINE ASPHYXIAL ENCEPHALOPATHY
    Peter Gluckman; Fiscal Year: 2001
    ..By further elucidating the pathogenesis of prenatal and perinatal asphyxial encephalopathy these studies will provide important information towards improving perinatal diagnosis, monitoring and intervention. ..
  29. CB1 Receptor Action on the Developing Hippocampus
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will result in new insights into the potential effects of cannabinoid action on the developing brain. ..
  30. Radioactive Iodide Therapy of Pediatric Graves' Disease
    Scott A Rivkees; Fiscal Year: 2010
    ....
  31. Mesenchymal Stem Cells for Fetal Gene Delivery
    Alice Tarantal; Fiscal Year: 2006
    ..abstract_text> ..
  32. MATERNAL DEHYDRATION--FETAL/AMNIOTIC FLUID HOMEOSTASIS
    Michael Ross; Fiscal Year: 2002
    ..The goal of this project is to determine critical efficacy and fetal safety issues central to maternal DDAVP treatment, prior to widespread clinical use in human pregnancies with oligohydramnios. ..
  33. Fetal Swallowing: Central Dipsogenic Mechanisms
    Michael Ross; Fiscal Year: 2007
    ..Furthermore, these studies represent a model to examine the development and function of neuronal pathways and mechanisms regulating fetal physiology. ..
  34. METVAN: A Novel Anticancer Agent
    OSMOND D CRUZ; Fiscal Year: 2003
    ..The knowledge gained from these studies described under Specific Aims 1-2 is expected to facilitate the design of innovative treatment regimens employing METVAN for metastatic breast cancer and brain tumor patients. ..
  35. 16th World Congress of Epidemiology
    David Savitz; Fiscal Year: 2002
    ..Symposia and scientific sessions for poster and oral presentations will provide a dynamic forum for discussion in all of these areas. ..
  36. DEVELOPING CIRCADIAN RHYTHMICITY
    Scott Rivkees; Fiscal Year: 2002
    ..These studies may also lead to the development of new care practices in Neonatal Intensive Care Units and extend the field of developmental chronobiology to the bedside. ..
  37. DEVELOPMENTAL EXPRESSION OF G-CSF IN THE PLACENTA
    DARLENE CALHOUN; Fiscal Year: 2002
    ....
  38. Center for Pediatric Stem/Progenitor Cell Translational Research
    Alice Tarantal; Fiscal Year: 2008
    ..If imaging techniques can be developed that allows one to monitor the cells over time, this would provide a very powerful tool to determine the fate of the cells after injection into humans. ..
  39. A-1 Adenosine Receptor Action in Developing Heart
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will identify Rho and ROCK as critical signaling molecules in heart development and reveal that cardiac GTPase activity transduces the effects of adenosine. ..
  40. Defining the Mammalian Intercellular Bridge Interactome
    Martin M Matzuk; Fiscal Year: 2010
    ..Our proposed Specific Aims will also help us to develop additional high throughput screening assays for the identification of small molecule disruptors of the intercellular bridge. ..
  41. PREVENTION AND TREATMENT OF HUMAN OLIGOHYDRAMNIOS
    Michael Ross; Fiscal Year: 2001
    ..e., failure to reset osmolality threshold). This proposal will aid in the development of markers of prediction and therapeutic approaches to the prevention and treatment of human oligohydramnios. ..
  42. Adenosinergic Mechanisms of Intrauterine Growth Retardation
    Scott A Rivkees; Fiscal Year: 2010
    ..The goals of this proposal are to identify the mechanisms by which adenosine acts to protect the embryo in utero and how altered embryonic adenosine action leads to long-term adverse effects in adulthood. ..
  43. NOVEL CONTRACEPTIVES WITH ANTI-HIV ACTIVITY
    OSMOND D CRUZ; Fiscal Year: 2001
    ..The preclinical data on in vivo efficacies of WHI-05 and WHI-07 will be essential to further explore the utility of these novel drugs for clinical studies in human patients. ..
  44. Anti-Adenosine Therapy of Neonatal Brain Injury
    Scott Rivkees; Fiscal Year: 2007
    ..It is anticipated that these studies will lead to novel and practical strategies for directly preventing brain injury. [unreadable] [unreadable]..
  45. PHI 346: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Following successful completion of the Phase I in vivo efficacy studies, gel formulation of PHI-346 will be further explored as a vaginal dual-function microbicide in Phase II. ..
  46. The Role of Adenosine in Hypoglycemic Brain Injury
    Scott Rivkees; Fiscal Year: 2003
    ..We anticipate that these studies will yield new insights into the mechanisms of hypoglycemic brain injury and may lead to the development of practical strategies for reducing hypoglycemic brain injury. ..
  47. Prenatal Insecticide Exposures Among Urban Minorities
    Robin Whyatt; Fiscal Year: 2005
    ..The research will provide important information about pesticide exposure during pregnancy among this minority cohort. ..
  48. Validation of biomarkers of prenatal pesticides exposure
    Robin Whyatt; Fiscal Year: 2003
    ....
  49. Center for Fetal Gene Transfer for HLB Diseases
    Alice Tarantal; Fiscal Year: 2005
    ..abstract_text> ..
  50. Vaccine therapy of congenital adrenal Hyperplasia
    Scott Rivkees; Fiscal Year: 2003
    ..We also anticipate being able to extend this novel approach to the treatment of other receptor-mediated endocrine disorders, such as hyperthyroidism. ..
  51. Phase II SBIR: WHI-07: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ....
  52. EARLY EVENTS IN NEURAL AND HOMEOGENETIC INDUCTION
    Claudio Stern; Fiscal Year: 2005
    ..D. To explore the possible roles of 6 newly-identified candidate secreted factors in the early steps of neural induction and homeogenetic induction. ..
  53. Mast Cell Role in Masseter Muscle Repair
    JOYCE MORRIS WIMAN; Fiscal Year: 2005
    ....
  54. Plurality and Contemporary Infant Mortality Risks
    Barbara Luke; Fiscal Year: 2006
    ..abstract_text> ..
  55. Stampidine: A Novel Broad-Spectrum Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of STAMP in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  56. Maternal Morbidity and Mortality in Multiple Pregnancy
    Barbara Luke; Fiscal Year: 2006
    ..The main hypothesis of this proposal is that higher plurality is the predominant factor affecting maternal morbidity and mortality, further potentated by older maternal age and primiparity. ..
  57. STRESS BIOLOGY, RACE/ETHNICITY & INFECTION IN PREGNANCY
    Pathik Wadhwa; Fiscal Year: 2006
    ..g., the ex-vivo immune challenge methodology) to identify women who are at heightened risk for infection and infection-related preterm birth, thereby improving obstetric risk assessment. ..
  58. A1-ADENOSINE RECEPTOR ACTION IN HIPPOCAMPUS
    Scott Rivkees; Fiscal Year: 2003
    ..We anticipate these studies will lead to new insights into the mechanisms of A1AR action. We also anticipate that these studies will identify A1ARs as an important regulator of axon growth. ..
  59. Regulation of Key Processes in Oocyte Biology
    Martin Matzuk; Fiscal Year: 2007
    ..Compromised fertility in knockout models lacking these oocyte-specific genes would demonstrate that these proteins are potential contraceptive targets and possibly mutated in infertile women. ..
  60. Prenatal TCDD and postnatal autoimmune disease
    Steven Holladay; Fiscal Year: 2007
    ..The collective experiments are designed to detect alterations in fetal immune development caused by TCDD that underlie the worsened postnatal (postpubertal) autoimmune disease caused by this chemical. ..