ejaculation

Summary

Summary: The emission of SEMEN to the exterior, resulting from the contraction of muscles surrounding the male internal urogenital ducts.

Top Publications

  1. ncbi Premature ejaculation: state of the art
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    Urol Clin North Am 34:591-9, vii-viii. 2007
  2. ncbi Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation
    Konstantinos Hatzimouratidis
    2nd Department of Urology, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Eur Urol 57:804-14. 2010
  3. ncbi Development and validation of a premature ejaculation diagnostic tool
    Tara Symonds
    Pfizer Ltd, Sandwich, Kent, UK
    Eur Urol 52:565-73. 2007
  4. ncbi [Study on the correlation of the 5-HTTLPR polymorphism with premature ejaculation in Han Chinese population]
    Shun wen Luo
    Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China
    Beijing Da Xue Xue Bao 43:514-8. 2011
  5. ncbi Analysis of association between the 5-HTTLPR and STin2 polymorphisms in the serotonin-transporter gene and clinical response to a selective serotonin reuptake inhibitor (sertraline) in patients with premature ejaculation
    Mohammad Reza Safarinejad
    Urology and Nephrology Research Centre, Shahid Beheshti University MC, Tehran, Iran
    BJU Int 105:73-8. 2010
  6. ncbi An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation
    Chris G McMahon
    Australian Center for Sexual Health, Sydney, Australia
    J Sex Med 5:1590-606. 2008
  7. ncbi Prevalence of premature ejaculation: a global and regional perspective
    Francesco Montorsi
    University Vita Salute San Raffaele, Milan, Italy
    J Sex Med 2:96-102. 2005
  8. ncbi No difference in 5-HTTLPR and Stin2 polymorphisms frequency between premature ejaculation patients and controls
    Daniela Zuccarello
    Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    J Sex Med 9:1659-68. 2012
  9. ncbi Serotonin transporter promoter region (5-HTTLPR) polymorphism is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation
    Paddy K C Janssen
    Section of Psychopharmacology, Department of Pharmaceutical Sciences and Rudolf Magnus Institute for Neurosciences, Utrecht University, Utrecht, The Netherlands
    J Sex Med 6:276-84. 2009
  10. ncbi Comparison of dapoxetine versus paroxetine in patients with premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study
    Mohammad Reza Safarinejad
    Urology Nephrology Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Clin Neuropharmacol 29:243-52. 2006

Research Grants

  1. PORTABILITY OF BIOCHEMICAL MARKERS OF SPERM MATURITY
    Gabor Huszar; Fiscal Year: 2001
  2. Phosphorylation Events During Sperm Capacitation
    PABLO EDUARDO VISCONTI; Fiscal Year: 2013
  3. STUDIES OF P2X ATP RECEPTORS
    RICHARD HUME; Fiscal Year: 2009
  4. Membrane Potential and cAMP Crosstalk in Sperm Capacitation
    PABLO EDUARDO VISCONTI; Fiscal Year: 2011
  5. Development of Eppin as a Male Contraceptive
    MICHAEL G O'RAND; Fiscal Year: 2013
  6. TISSUE SPECIFIC EXPRESSION AND FUNCTION OF ME-RABP
    Marie Claire Orgebin Crist; Fiscal Year: 2002
  7. MALE UROGENITAL FUNCTION AND CHRONIC SPINAL CORD INJURY
    Charles Hubscher; Fiscal Year: 2009
  8. SPINAL ORGANIZATION OF FUNCTION
    Kevin McKenna; Fiscal Year: 1991
  9. HORMONE-NEUROTRANSMITTER INTERACTIONS IN THE BRAIN
    Elaine Hull; Fiscal Year: 2004
  10. HORMONAL CONTROL OF SOCIAL BEHAVIOR
    Pauline Yahr; Fiscal Year: 1999

Detail Information

Publications322 found, 100 shown here

  1. ncbi Premature ejaculation: state of the art
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    Urol Clin North Am 34:591-9, vii-viii. 2007
    Premature ejaculation (PE) is a frequent male sexual complaint.This occurrence does not automatically imply the existence of a male sexual disorder...
  2. ncbi Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation
    Konstantinos Hatzimouratidis
    2nd Department of Urology, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Eur Urol 57:804-14. 2010
    Erectile dysfunction (ED) and premature ejaculation (PE) are the two most prevalent male sexual dysfunctions.
  3. ncbi Development and validation of a premature ejaculation diagnostic tool
    Tara Symonds
    Pfizer Ltd, Sandwich, Kent, UK
    Eur Urol 52:565-73. 2007
    Diagnosis of premature ejaculation (PE) for clinical trial purposes has typically relied on intravaginal ejaculation latency time (IELT) for entry, but this parameter does not capture the multidimensional nature of PE...
  4. ncbi [Study on the correlation of the 5-HTTLPR polymorphism with premature ejaculation in Han Chinese population]
    Shun wen Luo
    Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China
    Beijing Da Xue Xue Bao 43:514-8. 2011
    To investigate the relationship between 5-HT transporter gene-linked polymorphism (5-HTTPLR) and the clinical characters of premature ejaculation in Han Chinese population.
  5. ncbi Analysis of association between the 5-HTTLPR and STin2 polymorphisms in the serotonin-transporter gene and clinical response to a selective serotonin reuptake inhibitor (sertraline) in patients with premature ejaculation
    Mohammad Reza Safarinejad
    Urology and Nephrology Research Centre, Shahid Beheshti University MC, Tehran, Iran
    BJU Int 105:73-8. 2010
    ..that polymorphism within the gene-linked polymorphic region (5-HTTLPR) and second intron of SLC6A4 gene (STin2) is associated with selective serotonin-reuptake inhibitors (SSRIs) response in subjects with premature ejaculation (PE).
  6. ncbi An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation
    Chris G McMahon
    Australian Center for Sexual Health, Sydney, Australia
    J Sex Med 5:1590-606. 2008
    The medical literature contains several definitions of premature ejaculation (PE)...
  7. ncbi Prevalence of premature ejaculation: a global and regional perspective
    Francesco Montorsi
    University Vita Salute San Raffaele, Milan, Italy
    J Sex Med 2:96-102. 2005
    The effort to determine the global burden of premature ejaculation (PE) has been impeded by the lack of a clear and universally accepted definition of the condition...
  8. ncbi No difference in 5-HTTLPR and Stin2 polymorphisms frequency between premature ejaculation patients and controls
    Daniela Zuccarello
    Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    J Sex Med 9:1659-68. 2012
    Premature ejaculation (PE) is defined as the inability of men to control ejaculation and it is the most prevalent male sexual dysfunction...
  9. ncbi Serotonin transporter promoter region (5-HTTLPR) polymorphism is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation
    Paddy K C Janssen
    Section of Psychopharmacology, Department of Pharmaceutical Sciences and Rudolf Magnus Institute for Neurosciences, Utrecht University, Utrecht, The Netherlands
    J Sex Med 6:276-84. 2009
    Lifelong premature ejaculation (LPE) is characterized by persistent intravaginal ejaculation latency times (IELTs) of less than 1 minute, and has been postulated as a neurobiological dysfunction with genetic vulnerability for the short ..
  10. ncbi Comparison of dapoxetine versus paroxetine in patients with premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study
    Mohammad Reza Safarinejad
    Urology Nephrology Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Clin Neuropharmacol 29:243-52. 2006
    To compare the efficacy and safety of dapoxetine, paroxetine, and placebo for the oral pharmacotherapy of premature ejaculation.
  11. ncbi Female nutritional status determines the magnitude and sign of responses to a male ejaculate signal in Drosophila melanogaster
    C Fricke
    School of Biological Sciences, University of East Anglia, Norwich, UK
    J Evol Biol 23:157-65. 2010
    ..Hence, the food environment can also shape significantly the strength and direction of selection on mating responses...
  12. ncbi The beneficial effect of alfuzosin 10 mg once daily in 'real-life' practice on lower urinary tract symptoms (LUTS), quality of life and sexual dysfunction in men with LUTS and painful ejaculation
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston, ON, Canada
    BJU Int 97:1242-6. 2006
    ..safety of the selective alpha(1)-blocker alfuzosin in men with lower urinary tract symptoms (LUTS) and painful ejaculation, compared with those with LUTS only, as painful ejaculation is one of the most prevalent, differentiating and ..
  13. ncbi Premature ejaculation: different pathophysiologies and etiologies determine its treatment
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    J Sex Marital Ther 34:1-13. 2008
    Premature ejaculation (PE) is a frequent male sexual complaint. Its occurrence does not automatically imply the existence of a male sexual disorder...
  14. ncbi The use of old and recent DSM definitions of premature ejaculation in observational studies: a contribution to the present debate for a new classification of PE in the DSM-V
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    J Sex Med 5:1079-87. 2008
    The DSM-III definition of premature ejaculation (PE) contains the criterion "control" but not that of "ejaculation time...
  15. pmc Possible association of the 5-HTTLPR serotonin transporter promoter gene polymorphism with premature ejaculation in a Turkish population
    Emin Ozbek
    Department of Urology, Bezm i Alem Valide Sultan Vakif Gureba Research and Education Hospital, Istanbul 34095, Turkey
    Asian J Androl 11:351-5. 2009
    We evaluated the genotypes of the serotonin transporter gene (5-HTT) in patients with premature ejaculation (PE) to determine the role of genetic factors in the etiopathogenesis of PE and possibly to identify the patient subgroups...
  16. pmc Protein-specific manipulation of ejaculate composition in response to female mating status in Drosophila melanogaster
    Laura K Sirot
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 108:9922-6. 2011
    ..Furthermore, our results demonstrate sophisticated protein-specific ejaculate manipulation...
  17. ncbi Sexual harm reduction practices of HIV-seropositive gay and bisexual men: serosorting, strategic positioning, and withdrawal before ejaculation
    Jeffrey T Parsons
    Department of Psychology, Hunter College of the City University of New York, 695 Park Avenue, New York, NY 10021, USA
    AIDS 19:S13-25. 2005
    ..Here we focus on the use of three harm reduction strategies (serosorting, strategic positioning, and withdrawal before ejaculation) in order to decrease transmission risk.
  18. ncbi Polymorphisms of the serotonin transporter gene and their relation to premature ejaculation in individuals from Iran
    Mohammad Reza Safarinejad
    Urology and Nephrology Research Center, Shahid Beheshti University MC, Tehran, Iran
    J Urol 181:2656-61. 2009
    ..tested whether individuals with at least 1 copy of the short (S) or long (L)(G) allele of the serotonin transporter gene-linked polymorphic region exhibit a greater incidence of premature ejaculation compared with L(A)L(A) individuals.
  19. ncbi Increase of ejaculatory capacity by systemic administration of the oquichpatli (Senecio cardiophyllus) aqueous crude extract in male rats
    M Carro-Juárez
    Laboratory of Reproductive Behaviour, Veterinary Medical School, Autonomous University of Tlaxcala, P C 90000, Tlaxcala, Mexico
    J Ethnopharmacol 126:506-11. 2009
    To analyse the pro-ejaculatory properties of the proverbial Mexican plant oquichpatli, Senecio cardiophyllus, in an animal model for the study of ejaculation in spinal and anaesthetised male rats.
  20. ncbi Prevalence of the complaint of ejaculating prematurely and the four premature ejaculation syndromes: results from the Turkish Society of Andrology Sexual Health Survey
    Ege C Serefoglu
    Kiziltepe State Hospital, Kiziltepe, Mardin, Turkey
    J Sex Med 8:540-8. 2011
    In addition to the previously known lifelong and acquired premature ejaculation (PE) syndromes, the existence of two more PE syndromes has been suggested: natural variable PE and premature-like ejaculatory dysfunction...
  21. ncbi How does premature ejaculation impact a man s life?
    T Symonds
    Pfizer Global Research Development, Sandwich Laboratories, Pfizer Ltd, Kent, United Kingdom
    J Sex Marital Ther 29:361-70. 2003
    No systematic study has examined the psychological impact of premature ejaculation (PE) on the man and his partner. This study explores this vital issue by reporting on interviews of 28 men with self-diagnosed PE...
  22. ncbi On-demand SSRI treatment of premature ejaculation: pharmacodynamic limitations for relevant ejaculation delay and consequent solutions
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, Leyenburg Haga Hospital, The Hague, The Netherlands
    J Sex Med 2:121-31. 2005
    Recently, the idea has emerged that on-demand use of serotonin reuptake inhibitors (SSRIs), particularly short half-life, should be equally effective in delaying ejaculation as daily SSRI treatment of premature ejaculation.
  23. ncbi Premature and delayed ejaculation: two ends of a single continuum influenced by hormonal milieu
    G Corona
    Department of Clinical Physiopathology, Andrology Unit and Endocrinology, University of Florence, Florence, Italy
    Int J Androl 34:41-8. 2011
    ..Among the 2652 patients studied, 674 (25.2%) and 194 (7.3%) reported premature and delayed ejaculation (PE and DE), respectively...
  24. ncbi Central regulation of ejaculation
    Lique M Coolen
    Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati, Cincinnati, OH 45267 0521, USA
    Physiol Behav 83:203-15. 2004
    b>Ejaculation is a reflex mediated by a spinal control center, referred to as a spinal ejaculation generator...
  25. ncbi Effects of three types of alpha-1 adrenoceptor blocker on lower urinary tract symptoms and sexual function in males with benign prostatic hyperplasia
    Teruhiko Yokoyama
    Department of Urology, Kawasaki Medical School, Kurashiki, Okayama, Japan
    Int J Urol 18:225-30. 2011
    ....
  26. ncbi Dietary supplementation with a source of omega-3 fatty acids increases sperm number and the duration of ejaculation in boars
    M J Estienne
    Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Theriogenology 70:70-6. 2008
    ..3 x 10(9) during Weeks 8-15. Other semen characteristics were similar (P>0.1) between groups. Duration of ejaculation was affected by treatment (343.9s for controls and 388.8s for boars fed omega-3 fatty acids; S.E.M.=15.7; P=0...
  27. ncbi Anejaculation and retrograde ejaculation
    Dana A Ohl
    Division of Andrology and Microsurgery, Department of Urology, University of Michigan, 1500 E Medical Center Dr, Box 0330, Ann Arbor, MI 48108, USA
    Urol Clin North Am 35:211-20, viii. 2008
    ..Accurate diagnosis and choice of treatment plan must carefully proceed to maximize success rates while maintaining cost-effectiveness. In this article the authors review ejaculatory infertility evaluation and treatment...
  28. ncbi Turkish validation of the premature ejaculation diagnostic tool and its association with intravaginal ejaculatory latency time
    E C Serefoglu
    Department of Urology, Ataturk Teaching and Research Hospital, Bilkent, Ankara, Turkey
    Int J Impot Res 21:139-44. 2009
    There are uncertain issues on the diagnostic methods of premature ejaculation (PE)...
  29. ncbi Geometric mean IELT and premature ejaculation: appropriate statistics to avoid overestimation of treatment efficacy
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, Haga Hospital Leyenburg, The Hague, The Netherlands
    J Sex Med 5:492-9. 2008
    The intravaginal ejaculation latency time (IELT) behaves in a skewed manner and needs the appropriate statistics for correct interpretation of treatment results.
  30. ncbi The hormonal control of ejaculation
    Giovanni Corona
    Endocrinology Unit, Medical Department, Azienda Usl Bologna Maggiore Bellaria Hospital, Largo Nigrisoli 2, 40133 Bologna, Italy
    Nat Rev Urol 9:508-19. 2012
    ..Evidence shows that oxytocin is actively involved in regulating orgasm and ejaculation via peripheral, central and spinal mechanisms...
  31. ncbi Yohimbine in the treatment of orgasmic dysfunction
    Ade A Adeniyi
    Institute of Urology and Nephrology, London W1P 7EY, UK
    Asian J Androl 9:403-7. 2007
    ..To study the effect of yohimbine in the treatment of men with orgasmic dysfunction...
  32. ncbi An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine Ad Hoc Committee for the Definition of Premature Ejaculation
    Chris G McMahon
    Australian Center for Sexual Health, Sydney, Australia
    BJU Int 102:338-50. 2008
    To develop a contemporary, evidence-based definition of premature ejaculation (PE).
  33. ncbi Evaluation of premature ejaculation
    Emmanuele A Jannini
    Department of Experimental Medicine, School of Sexology, University of L Aquila, L Aquila, Italy
    J Sex Med 8:328-34. 2011
    Premature ejaculation (PE) is a prevalent, yet often underdiagnosed, sexual disorder that affects men of all ages...
  34. ncbi Brain activation during human male ejaculation
    Gert Holstege
    Department of Anatomy and Embryology, University of Groningen, 9713 AV Groningen, The Netherlands
    J Neurosci 23:9185-93. 2003
    Brain mechanisms that control human sexual behavior in general, and ejaculation in particular, are poorly understood...
  35. ncbi Retrograde ejaculation after anterior lumbar interbody fusion: transperitoneal versus retroperitoneal exposure
    Rick C Sasso
    Indianapolis Neurosurgical Group, Indianapolis, Indiana, USA
    Spine (Phila Pa 1976) 28:1023-6. 2003
    ..All the patients were advised before surgery of the risk for retrograde ejaculation. After surgery, any case of retrograde ejaculation was recorded as an adverse event, and the patient was ..
  36. ncbi Retrograde ejaculation after anterior lumbar interbody fusion using rhBMP-2: a cohort controlled study
    Eugene J Carragee
    Stanford University School of Medicine, 450 Broadway St, Redwood City, CA 94063, USA
    Spine J 11:511-6. 2011
    ..original Food and Drug Administration Summary of anterior lumbar interbody fusion (ALIF) reported 12 retrograde ejaculation (RE) events (8%) in the rhBMP-2 groups compared with (1.4%) in the control group...
  37. pmc Prevalence of premature ejaculation in young and middle-aged men in Korea: a multicenter internet-based survey from the Korean Andrological Society
    Hyun Jun Park
    Deparment of Urology, Pusan National University School of Medicine, Busan 602739, Korea
    Asian J Androl 12:880-9. 2010
    In this study, we aimed to investigate the prevalence and perception of premature ejaculation (PE) in young and middle-aged Korean men. The study was conducted using an Internet-assisted questionnaire...
  38. ncbi Impact of premature ejaculation: the psychological, quality of life, and sexual relationship consequences
    Raymond C Rosen
    New England Research Institutes, Watertown, MA, USA
    J Sex Med 5:1296-307. 2008
    Premature ejaculation (PE) has been associated with a range of negative psychological effects, including anxiety, depression, and distress in men and their female partners.
  39. ncbi Activation of POMC neurons during general arousal but not sexual behavior in male rats
    Brooke A Davis
    Neuroscience Graduate Program, Department of Cell Biology, University of Cincinnati, Cincinnati, OH, USA
    Behav Neurosci 121:1012-22. 2007
    ....
  40. ncbi Activation of gastrin-releasing peptide receptors in the lumbosacral spinal cord is required for ejaculation in male rats
    Natalie Kozyrev
    University of Michigan, Department of Molecular and Integrative Physiology, Ann Arbor, MI 48109, USA
    J Sex Med 9:1303-18. 2012
    b>Ejaculation is a complex reflex mediated by a spinal ejaculation generator located in the lumbosacral spinal cord and consisting of a population of lumbar spinothalamic (LSt) neurons...
  41. pmc Alpha1-adrenoceptors and ejaculatory function
    M C Michel
    Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Br J Pharmacol 152:289-90. 2007
    The abnormal ejaculation of semen is a typical but infrequent side effect of some alpha(1)-adrenoceptor antagonists, particularly those with selectivity for alpha(1A)-adrenoceptors such as silodosin or tamsulosin...
  42. ncbi Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis
    M D Waldinger
    Department of Psychiatry and Neurosexology, Leyenburg Hospital, The Hague, The Netherlands
    Int J Impot Res 16:369-81. 2004
    ..and meta-analysis is to evaluate whether the design and methodology of drug-treatment studies of premature ejaculation affect the efficacy outcome differently...
  43. ncbi A multinational population survey of intravaginal ejaculation latency time
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, Leyenburg HagaHospital, The Hague, and Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands
    J Sex Med 2:492-7. 2005
    Intravaginal ejaculation latency time (IELT), defined as the time between the start of vaginal intromission and the start of intravaginal ejaculation, is increasingly used in clinical trials to assess the amount of selective serotonin ..
  44. ncbi International Society for Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation
    Stanley E Althof
    Department of Psychiatry, University of Miami Miller School of Medicine, West Palm Beach, FL, USA
    J Sex Med 7:2947-69. 2010
    Over the past 20 years our knowledge of premature ejaculation (PE) has significantly advanced...
  45. pmc Sexual reward in male rats: effects of sexual experience on conditioned place preferences associated with ejaculation and intromissions
    Christine M Tenk
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Horm Behav 55:93-7. 2009
    ..Therefore, this study used a conditioned place preference (CPP) paradigm to address whether ejaculation and intromissions differ in their rewarding incentive values...
  46. ncbi Inhibition of Seminal emission is the main cause of anejaculation induced by a new highly selective alpha1A-blocker in normal volunteers
    Ko Kobayashi
    Sapporo Medical University School of Medicine, Sapporo, Japan
    J Sex Med 5:2185-90. 2008
    ..Recent studies have highlighted the influence of alpha1-adrenoceptor antagonists on ejaculatory function...
  47. ncbi The association between varicocele, premature ejaculation and prostatitis symptoms: possible mechanisms
    Francesco Lotti
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence 50139, Italy
    J Sex Med 6:2878-87. 2009
    ..No study has ever systematically evaluated the impact of varicocele on sexual function...
  48. ncbi Association between polymorphisms in the serotonin 2C receptor gene and premature ejaculation in Han Chinese subjects
    Shunwen Luo
    Urological Department, West China Hospital, Sichuan University, Chengdu, China
    Urol Int 85:204-8. 2010
    Lifelong premature ejaculation (LPE) is characterized by persistently shorter intravaginal ejaculation latency time (IELT) than found acceptable by the patient or his partner...
  49. ncbi Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials
    Jon L Pryor
    University of Minnesota, Minneapolis, MN 55455, USA
    Lancet 368:929-37. 2006
    No drugs are approved for treatment of premature ejaculation. Our aim was to determine the efficacy and tolerability of on-demand dapoxetine in patients with severe premature ejaculation.
  50. ncbi Pharmacology of alpha1-adrenoceptor antagonists in the lower urinary tract and central nervous system
    Karl Erik Andersson
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Nat Clin Pract Urol 4:368-78. 2007
    ....
  51. ncbi Preliminary results on selective light vaporization with the side-firing 980 nm diode laser in benign prostatic hyperplasia: an ejaculation sparing technique
    R Leonardi
    Department of Urology, Clinica Basile, Catania, Italy
    Prostate Cancer Prostatic Dis 12:277-80. 2009
    ..None of the patients complained of a worsening of erectile function. This early experience in a pilot study with the 980 nm diode laser seems promising in the short-term and long-term outcome is being monitored...
  52. ncbi Premature ejaculation: definition and drug treatment
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    Drugs 67:547-68. 2007
    Premature ejaculation (PE) is a frequent male sexual complaint that is mediated mainly by disturbances of serotonergic neurotransmission and certain serotonin (5-HT) receptors and, to a lesser extent, oxytocinergic neurotransmission in ..
  53. ncbi Emerging drugs for premature ejaculation
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, Leyweg 275, 2545 CH, The Hague, The Netherlands
    Expert Opin Emerg Drugs 11:99-109. 2006
    Lifelong premature ejaculation (PE) is a frequent male sexual dysfunction and is thought to be mediated in part by disturbances of serotonergic (5-hydroxytryptamine; 5-HT) neurotransmission and ejaculation-mediating 5-HT receptors in the ..
  54. ncbi The spinal pattern generator for ejaculation
    Miguel Carro-Juárez
    Laboratorio de Comportamiento Reproductivo, Escuela de Medicina Veterinaria y Zootecnia, Universidad Autonoma de Tlaxcala, C P 90000, Tlaxcala, Mexico
    Brain Res Rev 58:106-20. 2008
    b>Ejaculation is the physiological process that describes the expulsion of the semen from the urethra...
  55. ncbi The influence of ejaculation and abstinence on urinary flow rates
    Luca Cindolo
    Urology Department, S Pio da Pietrelcina Hospital, Vasto, Italy
    Neurourol Urodyn 30:1571-5. 2011
    To investigate the relationship between urinary flow rate and ejaculation in healthy young men.
  56. ncbi Premature ejaculation and other sexual dysfunctions in opiate dependent men receiving methadone substitution treatment
    Venkat Chekuri
    General Adult Psychiatry, Parkhead Hospital, Glasgow G315EB, United Kingdom
    Addict Behav 37:124-6. 2012
    A significant number of men with opiate misuse have sexual problems. Premature ejaculation (PE) occurs predominantly on discontinuation of the opiate but seems to persist in some cases...
  57. ncbi TEMPE: Topical Eutectic-Like Mixture for Premature Ejaculation
    Richard Henry
    Queen s University, Department of Anesthesiology, Kingston General Hospital, 76 Stuart Street, Kingston, Ontario, K7L 2V7, Canada
    Expert Opin Drug Deliv 5:251-61. 2008
    Premature ejaculation (also known as rapid or early ejaculation) is the most common form of sexual dysfunction experienced by men, but there is presently an unmet need for a licensed pharmaceutical product that can be used on demand and ..
  58. ncbi Frequency of ejaculation and risk of prostate cancer
    Graham G Giles
    JAMA 292:329; author reply 329. 2004
  59. ncbi An overview of pharmacotherapy in premature ejaculation
    Hartmut Porst
    Private Urology and Andrology Practice and Hospital, Hamburg, Germany
    J Sex Med 8:335-41. 2011
    With increasing interest and clinical research in male sexual disorders, it has become clear that not only psychological but also organic, neurobiological, and genetic factors may play an important role in premature ejaculation (PE).
  60. ncbi Evidence for a genetic etiology to ejaculatory dysfunction
    P Jern
    Department of Psychology, Center of Excellence in Behavior Genetics, Abo Akademi University, Turku, Finland
    Int J Impot Res 21:62-7. 2009
    ..have been proposed, but no study has yet found conclusive evidence that premature (PE) or delayed (DE) ejaculation is under genetic control...
  61. ncbi Serum leptin levels in patients with premature ejaculation
    M Atmaca
    Department of Psychiatry, Firat University, School of Medicine, Elazig, Turkey
    Arch Androl 48:345-50. 2002
    ..The inhibitory effect of serotonin on libido, ejaculation, and orgasm is well documented...
  62. ncbi Relationship between premature ejaculation and genetic polymorphisms of the dopamine transporter gene (SLC6A3)
    Mohammad Reza Safarinejad
    Private Practice of Urology and Andrology, Tehran, Iran
    BJU Int 108:292-6. 2011
    To investigate the possible relationships between premature ejaculation (PE) polymorphisms in the dopamine transporter (DAT) gene (SLC6A3, DAT1), which has a polymorphic 40 base pair (40 bp) variable number of tandem repeats (VNTR) ..
  63. ncbi Pro-ejaculatory effect of the aqueous crude extract of cihuapatli (Montanoa tomentosa) in spinal male rats
    Miguel Carro-Juárez
    Laboratorio de Comportamiento Reproductivo, Escuela de Medicina Veterinaria y Zootecnia, Universidad Autonoma de Tlaxcala, CP 90000, AP 484, Col Centro, Tlaxcala, Mexico
    J Ethnopharmacol 106:111-6. 2006
    ....
  64. ncbi Premature ejaculation and serum leptin level: a diagnostic case-control study
    Mohammad Reza Nikoobakht
    Urology Research Center, Sina Hospital, Medical Sciences, University of Tehran, Tehran, Iran
    J Sex Med 5:2942-6. 2008
    Premature ejaculation (PE) is regarded as the most common male sexual disorder. To date, there is no accurate and objective diagnostic test for PE.
  65. ncbi Retrograde ejaculation after anterior lumbar spine surgery
    Emily M Lindley
    Department of Orthopaedics, The Spine Center, University of Colorado Denver, Anschutz Medical Campus, Denver, CO, USA
    Spine (Phila Pa 1976) 37:1785-9. 2012
    ..A retrospective cohort study...
  66. ncbi Evidence for the involvement of a spinal pattern generator in the control of the genital motor pattern of ejaculation
    Miguel Carro-Juárez
    Laboratorio de Comportamiento Reproductivo, Escuela de Medicina Veterinaria y Zootecnia, Universidad Autonoma de Tlaxcala, C P 90000, Tlaxcala, Mexico
    Brain Res 975:222-8. 2003
    ..a CPG at a spinal level is involved in the expression and pacing of the rhythmic motor pattern generated during ejaculation. To this purpose we used the genital reflex as a model system...
  67. ncbi Development and in vitro testing of a new method of urine preparation for retrograde ejaculation; the Liverpool solution
    Thomas R Aust
    Hewitt Centre for Reproductive Medicine, Liverpool Women s Hospital, Liverpool, Merseyside, United Kingdom
    Fertil Steril 89:885-91. 2008
    To design a new method for oral preparation of urine for sperm retrieval after retrograde ejaculation (RE) and to test the motility of sperm exposed to prepared and unprepared urine.
  68. ncbi Erectile dysfunction and premature ejaculation are the most frequently self-reported sexual concerns: profiles of 9,536 men calling a helpline
    Stamatis Papaharitou
    Centre for Sexual and Reproductive Health, Aristotle University of Thessaloniki, Greece
    Eur Urol 49:557-63. 2006
    ..To describe the range of sexual problems, as reported by men calling a help-line and to investigate factors associated with help seeking behaviour...
  69. ncbi Comparison of intracytoplasmic sperm injection outcomes between spermatozoa retrieved from testicular biopsy and from ejaculation in cryptozoospermic men
    N Amirjannati
    Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
    Andrologia 44:704-9. 2012
    ....
  70. ncbi Participation of endogenous opioids in the inhibition of the spinal generator for ejaculation in rats
    Miguel Carro-Juárez
    Laboratorio de Comportamiento Reproductivo, Escuela de Medicina Veterinaria y Zootecnia, Universidad Autonoma de Tlaxcala, Av Universidad No 1, Col La Loma Xicohtencatl, Tlaxcala 90000, Mexico
    J Sex Med 6:3045-55. 2009
    A spinal pattern generator controls the expression of ejaculation. When this ejaculation generator is activated it can be phasically controlled, at a spinal level, by intrinsic mechanisms that eventually lead to the establishment of both ..
  71. ncbi Sexual dysfunction in partners of men with premature ejaculation
    K Hobbs
    Worldwide Outcomes Research, Pfizer Ltd, Sandwich, UK
    Int J Impot Res 20:512-7. 2008
    ..little research has been conducted in partners of men with other sexual dysfunctions, such as premature ejaculation (PE)...
  72. ncbi Premature ejaculation: a psychophysiological approach for assessment and management
    M E Metz
    Meta Associates, St Paul, Minnesota 55114, USA
    J Sex Marital Ther 26:293-320. 2000
    This article distinguishes several subtypes of biogenic and psychogenic premature ejaculation (PE) according to their etiologic features: the physiological PE types of (a) neurologic constitution, (b) acute physical illness, (c) physical ..
  73. pmc Evaluation of the excopula ejaculatory potentials of Bersama engleriana in spinal male rats
    Pierre Watcho
    Animal Physiology and Phytopharmacology Laboratory, University of Dschang, Dschang, P O BOX 67, Cameroon
    Asian J Androl 11:533-9. 2009
    ..The aim of this study was to investigate the effects of Bersama engleriana and its potential mechanism on fictive ejaculation in spinal male rats...
  74. ncbi Candidate molecule for premature ejaculation, DA-8031: in vivo and in vitro characterization of DA-8031
    Hyung Jun Jeon
    Research Laboratory, Dong A Pharmaceutical Company, Giheung, Yongin, Gyeonggi, Korea
    Urology 77:1006.e17-21. 2011
    To evaluate the efficacy of DA-8031 against premature ejaculation, we performed in vitro and in vivo pharmacologic studies.
  75. ncbi Social phobia and premature ejaculation: a case-control study
    Jean Tignol
    Department of Psychiatry, University Victor Segalen School of Medicine and Charles Perrens Hospital, Bordeaux Cedex, France
    Depress Anxiety 23:153-7. 2006
    ..On this basis, our aim in this study was to test the hypothesis that premature ejaculation (PE) as a specific sexual disorder and SP might be strongly related, by comparing subjects with PE to a control ..
  76. ncbi Safety and efficacy of citalopram in the treatment of premature ejaculation: a double-blind placebo-controlled, fixed dose, randomized study
    M R Safarinejad
    Urology Nephrology Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Int J Impot Res 18:164-9. 2006
    ..a potent and highly selective serotonin reuptake inhibitor (SSRI) antidepressant, in patients with premature ejaculation (PE). In total, 58 potent men with PE were included in the study...
  77. ncbi The psychology of premature ejaculation: therapies and consequences
    Stanley Althof
    Center for Marital and Sexual Health of South Florida, FL 11100, USA
    J Sex Med 3:324-31. 2006
    Premature ejaculation (PE) is a common male sexual dysfunction characterized by the loss or absence of ejaculatory control, marked distress or interpersonal difficulty and by a short intravaginal ejaculatory latency time (IELT)...
  78. pmc Brain oxytocin receptors mediate ejaculation elicited by 7-hydroxy-2-(di-N-propylamino) tetralin (7-OH-DPAT) in anaesthetized rats
    P Clement
    Pelvipharm Laboratories, Parc d Orsay, Orsay, France
    Br J Pharmacol 154:1150-9. 2008
    ..c.v. 7-hydroxy-2-(di-N-propylamino) tetralin (7-OH-DPAT), a dopamine agonist, preferentially active on D3 receptors...
  79. ncbi Distinguishing premature ejaculation from other sexual function disorders
    Martin Miner
    Department of Family Medicine, Warren Alpert School of Medicine, Brown University, and Men s Health Center, Miriam Hospital, Providence, RI 02906, USA
    Postgrad Med 120:54-63. 2008
    ..Premature ejaculation affects many men, and current pharmacologic treatment options are limited to off-label use of medications ..
  80. ncbi Cognitive and partner-related factors in rapid ejaculation: differences between dysfunctional and functional men
    U Hartmann
    Clinical Psychology, Deptartment of Clinical Psychiatry and Psychotherapy, Hanover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    World J Urol 23:93-101. 2005
    Despite the high prevalence of rapid ejaculation in community samples, there is still a paucity of data on cognitive and other relevant aspects of the subjective experience of premature ejaculation (PE) patients and their functional ..
  81. ncbi Neural control of ejaculation
    Lique M Coolen
    Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Comp Neurol 493:39-45. 2005
    b>Ejaculation is the most reinforcing component of sexual behavior. However, the neural substrates mediating ejaculation and processing ejaculation-related signals remain poorly understood...
  82. ncbi Peculiarities of semen coagulation and liquefaction in males from infertile couples
    Vladimir V Mikhailichenko
    Department of Urology and Andrology, State Medical Academy of Postgraduate Studies, Saint Petersburg, Russia
    Fertil Steril 84:256-9. 2005
    ..Semen liquefaction was mostly of a cascade nature (one- and two-cascade types), but viscid ejaculates often liquefied slowly and monotonously (monotonous type of liquefaction)...
  83. ncbi Validation of the hospital anxiety and depression scale and the psychological disorder among premature ejaculation subjects
    Q K Fatt
    School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Petaling Jaya, Selangor Darul Ehsan, Malaysia
    Int J Impot Res 19:321-5. 2007
    Premature ejaculation (PE) is a common sexual dysfunction among the general population. PE has often been associated with a psychological state of mind...
  84. ncbi [Ejaculatory disorder by alpha-1 adrenoceptor antagonist in patients with benign prostatic hyperplasia; retrospective comparison between naftopidil and tamsulosin]
    Ryoji Furuya
    The Department of Urology, Furuya Hospital
    Hinyokika Kiyo 51:763-6. 2005
    ..quot; Our results indicated that ejaculatory disorders occurred more frequently in the tamsulosin group. We should inform patients about this adverse effect caused by alpha-1 adrenoceptor antagonists prior to treatment...
  85. ncbi Safety and efficacy of escitalopram in the treatment of premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study
    Mohammad Reza Safarinejad
    Department of Urology, Urology and Nephrology Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    J Clin Psychopharmacol 27:444-50. 2007
    To evaluate the efficacy and safety of most selective serotonin reuptake inhibitor drug, escitalopram, in delaying ejaculation in patients with premature ejaculation (PE).
  86. ncbi The Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision as an appropriate diagnostic for premature ejaculation
    Ridwan Shabsigh
    Maimonides Medical Center, New York, NY, USA
    J Sex Med 4:1468-78. 2007
    ..and Statistical Manual of Mental Disorders, fourth edition, text revision (DSM-IV-TR) criteria for premature ejaculation (PE) are multifactorial, and include concepts of latency, perceived control over ejaculation, and personal ..
  87. ncbi Physiological roles of semenogelin I and zinc in sperm motility and semen coagulation on ejaculation in humans
    Kaoru Yoshida
    Biomedical Engineering Center, Toin University of Yokohama, 1614 Kurogane cho, Aoba ku, Yokohama 225 8502, Japan
    Mol Hum Reprod 14:151-6. 2008
    At ejaculation, human sperm are considered to be mechanically trapped and become immotile in the semen coagulum by binding to semenogelins (Sgs) from the seminal vesicle and zinc ions from the prostate...
  88. ncbi Factors associated with unprotected receptive anal intercourse with internal ejaculation among men who have sex with men in a large Internet sample from Asia
    Sin How Lim
    Centre of Excellence for Research in AIDS CERiA, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    AIDS Behav 16:1979-87. 2012
    ..who have sex with men (MSM) residing in Asia and correlates of unprotected receptive intercourse with Internet ejaculation (URAIE)...
  89. ncbi The management of retrograde ejaculation: a systematic review and update
    Amanda Jefferys
    Department of Women s Health, Southmead Hospital, Bristol, United Kingdom
    Fertil Steril 97:306-12. 2012
    To determine the best management of retrograde ejaculation to optimize the chance of conception.
  90. ncbi Delay of ejaculation induced by SB-277011, a selective dopamine D3 receptor antagonist, in the rat
    Pierre Clement
    Pelvipharm Laboratories, Orsay, France
    J Sex Med 6:980-8. 2009
    ..in different aspects of the male sexual response, including sexual motivation and arousal, penile erection, and ejaculation. The modalities of action of DA are however unclear, although the various DA receptors may differentially ..
  91. ncbi Complications and the effect of varicocelectomy on semen analysis, fertility, early ejaculation and spontaneous abortion
    Ali Shamsa
    Department of Urology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
    Saudi J Kidney Dis Transpl 21:1100-5. 2010
    Varicocele is still an enigma. Its effects on semen analysis, fertility and, more recently, early ejaculation and spontaneous abortion in spouses are not yet fully understood...
  92. ncbi Sequence of ejaculation affects the spermatozoon as a carrier and its message
    Lars Björndahl
    Assisted Conception Unit, Birmingham Women s Hospital and Reproductive Biology and Genetics Group, University of Birmingham, Metchley Park Road, Birmingham B15 2TG, UK
    Reprod Biomed Online 7:440-8. 2003
    It is a widespread misunderstanding that the human ejaculation produces a homogeneous fluid with constant environment for the spermatozoa...
  93. ncbi What does premature ejaculation mean to the man, the woman, and the couple?
    Alessandra Graziottin
    Center of Gynecology and Medical Sexology, H San Raffaele Resnati, Milan, Italy
    J Sex Med 8:304-9. 2011
    The relational impact of male and female sexual dysfunction, and specifically premature ejaculation (PE), is an important consideration. Published findings are consistent in identifying the negative psychosocial impact of PE on the man...
  94. ncbi Pathophysiology of premature ejaculation
    Jacques Buvat
    Centre d Etude et de Traitement de la Pathologie de l Appareil Reproducteur et de la Psychosomatique, Lille, France
    J Sex Med 8:316-27. 2011
    Although the characteristics of premature ejaculation (PE) are established, the exact aetiology is largely unknown. Genetic, neurobiological, pharmacological, psychological, urological and endocrine factors have all been proposed...
  95. ncbi Relationship between premature ejaculation and depression in Korean males
    Hwancheol Son
    Department of Urology, Seoul National University Boramae Hospital, Seoul, Korea
    J Sex Med 8:2062-70. 2011
    The psychological impacts of premature ejaculation (PE), which include guilt, anxiety, and distress, have been well established in Western countries...
  96. ncbi Prevalence of premature ejaculation in Turkish men with chronic pelvic pain syndrome
    Murat Gonen
    Department of Urology, Baskent University School of Medicine, Konya, Turkey
    J Androl 26:601-3. 2005
    ..Limited studies exist on the relation of this condition to premature ejaculation. We evaluated prevalence rates of premature ejaculation in Turkish male patients with chronic pelvic pain ..
  97. ncbi Dapoxetine for premature ejaculation
    A M Feige
    Department of Urology, Tulane Health Sciences Center, New Orleans, Louisiana, USA
    Clin Pharmacol Ther 89:125-8. 2011
    Premature ejaculation (PE) is the most common form of male sexual dysfunction, with an estimated worldwide prevalence of 20–30%.1 Although PE is not life threatening, it has significant impact on quality of life...
  98. ncbi Central neurophysiology and dopaminergic control of ejaculation
    Magali Peeters
    Pelvipharm Laboratories, Gif sur Yvette, France
    Neurosci Biobehav Rev 32:438-53. 2008
    Although premature ejaculation (PE) represents the most common male sexual dysfunction, brain mechanisms controlling ejaculatory process remain poorly understood...
  99. ncbi Baseline characteristics and treatment outcomes for men with acquired or lifelong premature ejaculation with mild or no erectile dysfunction: integrated analyses of two phase 3 dapoxetine trials
    Hartmut Porst
    J Sex Med 7:2231-42. 2010
    Premature ejaculation (PE) is classified as an acquired or lifelong condition but data on baseline characteristics and response to treatment of men with acquired or lifelong PE and mild erectile dysfunction (ED) or normal erectile ..
  100. ncbi Pharmacokinetic and pharmacodynamic features of dapoxetine, a novel drug for 'on-demand' treatment of premature ejaculation
    Karl Erik Andersson
    Department of Clinical and Experimental Pharmacology, Lund University, Hospital, Lund, Sweden
    BJU Int 97:311-5. 2006
    To describe the relationship between the pharmacokinetic and pharmacodynamic properties of dapoxetine, a drug specifically developed for treating premature ejaculation (PE).
  101. ncbi Efficacy and safety of dapoxetine for the treatment of premature ejaculation: integrated analysis of results from five phase 3 trials
    Chris G McMahon
    Australian Centre for Sexual Health, St Leonards, New South Wales, Australia
    J Sex Med 8:524-39. 2011
    Dapoxetine has been evaluated for the on-demand treatment of premature ejaculation (PE) in five phase 3 studies in various populations worldwide and has recently been approved in several countries.

Research Grants62

  1. PORTABILITY OF BIOCHEMICAL MARKERS OF SPERM MATURITY
    Gabor Huszar; Fiscal Year: 2001
    ..of sperm viability with visible wavelength stains, preservation of the proportion of viable sperm at time of ejaculation, CK-M antibody coupled to chromophores for one-step sperm immunostaining, measurement of CK-M directly in semen ..
  2. Phosphorylation Events During Sperm Capacitation
    PABLO EDUARDO VISCONTI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mammalian sperm are not able to fertilize eggs immediately after ejaculation. They acquire fertilization capacity in the female tract in a process known as capacitation...
  3. STUDIES OF P2X ATP RECEPTORS
    RICHARD HUME; Fiscal Year: 2009
    ..knocked out show dysfunction in pain perception, ability to void the bladder, gut motility, neuronal control of ejaculation, the ability of the nervous system to monitor the oxygen level in the blood, the ability to fight bacterial ..
  4. Membrane Potential and cAMP Crosstalk in Sperm Capacitation
    PABLO EDUARDO VISCONTI; Fiscal Year: 2011
    Mammalian sperm are not able to fertilize eggs immediately after ejaculation. They acquire fertilization capacity after residing in the female tract for a finite period of time in a process known as capacitation [24, 25]...
  5. Development of Eppin as a Male Contraceptive
    MICHAEL G O'RAND; Fiscal Year: 2013
    ..semenogelin on the human sperm surface, particularly with regard to the resumption of sperm motility following ejaculation. Since our publication in Science in 2004 on the complete and reversible contraception of male monkeys ..
  6. TISSUE SPECIFIC EXPRESSION AND FUNCTION OF ME-RABP
    Marie Claire Orgebin Crist; Fiscal Year: 2002
    In the epididymis spermatozoa mature, gain the ability to fertilize in vivo and are stored prior to ejaculation. Vitamin A is important in epididymal function since it is required to maintain epithelial structures...
  7. MALE UROGENITAL FUNCTION AND CHRONIC SPINAL CORD INJURY
    Charles Hubscher; Fiscal Year: 2009
    Deficits in ejaculation, urination, and defecation are among of the most devastating outcomes of spinal cord injury (SCI), severely affecting quality of life...
  8. SPINAL ORGANIZATION OF FUNCTION
    Kevin McKenna; Fiscal Year: 1991
    ..These findings have prompted a unifying hypothesis which proposes that ejaculation is induced by mechanical and chemical stimulation of the urethra by seminal fluids...
  9. HORMONE-NEUROTRANSMITTER INTERACTIONS IN THE BRAIN
    Elaine Hull; Fiscal Year: 2004
    ..the facilitative effects of a DA agonist release in the anterior lateral hypothalamus (LHA) at the time of ejaculation; a selective serotonin reuptake inhibitor (SSRI) injected there delays the onset of copulation and inhibits ..
  10. HORMONAL CONTROL OF SOCIAL BEHAVIOR
    Pauline Yahr; Fiscal Year: 1999
    ..is connected to the mSDA, and the posterodorsal preoptic nucleus, which is near the SDA, respond only with ejaculation. The remaining aims of the research are 6) to test whether either the PdPN or MeApd is causally related to ..
  11. PSYCHOENDOCRINE CONTROL OF ESTROUS BEHAVIOR
    MARY ERSKINE; Fiscal Year: 2000
    ..the mating sequence; females display selective responses to mounts - without intromission, intromission, and ejaculation. The resulting pattern of cervical-vaginal stimulation received significantly increases the incidence of PSP or ..
  12. St. John's Wort vs Placebo in Social Phobia
    Kenneth Kobak; Fiscal Year: 2002
    ..indication), 27 percent reported somnolence, 26 percent nausea, and 37 percent of males reported delayed ejaculation; 34 percent of patients discontinued the trial early. There has been considerable worldwide interest in St...
  13. MICROSTIMULATION OF THE LUMBOSACRAL SPINAL CORD- MAPPING
    WARREN GRILL; Fiscal Year: 2000
    ..Likewise, discrete control of penile erection, ejaculation, bowel evacuation, and control of the somatic musculature of the limbs may be possible by selective spinal cord ..
  14. MICROSTIMULATION OF THE LUMBOSACRAL SPINAL CORD- MAPPING
    James Roppolo; Fiscal Year: 1999
    ..Likewise, discrete control of penile erection, ejaculation, bowel evacuation, and control of the somatic musculature of the limbs may be possible by selective spinal cord ..
  15. MICROSTIMULATION OF THE LUMBOSACRAL SPINAL CORD--CHRONI
    Douglas McCreery; Fiscal Year: 1999
    ..Likewise, discrete control of penile erection, ejaculation, bowel evacuation and control of the somatic musculature of the limbs may be possible by selective spinal cord ..
  16. THE ROLE OF OXYTOCIN IN MALE SEXUAL FUNCTION
    Kevin McKenna; Fiscal Year: 2002
    ..from the paraventricular nucleus to lumbosacral spinal cord as a potent facilitator of penile erection and ejaculation. The neurotransmitter for this excitation is the peptide oxytocin...
  17. HCO3 and Na+ transport in human & pig vas deferens
    Bruce Schultz; Fiscal Year: 2004
    ..for neurotransmitter-dependent mechanisms to acutely alkalinize the lumen for sperm activation just prior to ejaculation and provides a basis to account for male factor infertility that is currently diagnosed as 'idiopathic...
  18. CHRONIC PROSTATITIS COLLABORATIVE CLINICAL STUDIES
    Richard Alexander; Fiscal Year: 1999
    ..region, irritative and obstructive voiding symptoms, and difficulties with sexual function, including painful ejaculation. These symptoms are indistinguishable from those of men with infection of the prostate gland, and an infectious ..
  19. Na+ and K+ role in capacitation-associated hyperpolariz*
    Pablo Visconti; Fiscal Year: 2005
    ..Mammalian sperm are not able to fertilize eggs immediately after ejaculation. They acquire the capacity to fertilize after residing in the female tract for a finite period of time...
  20. EFFECTS OF PRENATAL STRESS ON ADULT SEXUAL BEHAVIOR
    INGEBORG WARD; Fiscal Year: 1990
    ..g. ejaculation, lordosis) and nonsexual (e.g...
  21. Sexual Dysfunction and Diabetes:Look AHEAD Sub-Study
    Stephen Schneider; Fiscal Year: 2006
    ..iii) Finally, the proposed sub-study will investigate the relationship between changes in sexual function and quality of life outcomes. ..
  22. PDE-5 Inhibition in HIV+ and HIV- Men
    Raymond Rosen; Fiscal Year: 2005
    ..Key personnel for the project are Raymond C. Rosen, Ph.D., Professor of Psychiatry and Medicine at UMDNJ, who will serve as PI, and Joseph Catania, PhD, co-PI, from the AIDS Research Institute at UCSF. ..
  23. Quality Life Among Youth with Craniofacial Conditions
    Donald Patrick; Fiscal Year: 2004
    ..S., and one in the United Kingdom. Adolescents and their parents will complete questionnaires at baseline, and gain at 1-2 year clinical follow-up. ..
  24. Hearing Loss and Quality of Life of Children and Youth
    Donald Patrick; Fiscal Year: 2009
    ....
  25. Quality of Life of Overweight Youth: Multicultural View
    Donald Patrick; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  26. Studies on the Eppin family of proteins on chromosome 20
    MICHAEL G O apos RAND; Fiscal Year: 2010
    ..with prostate specific antigen (PSA), and its role during the resumption of sperm motility following ejaculation. Very few molecular details are known about the protein-protein interactions that occur on the sperm surface ..
  27. MAMMALIAN SPERM SURFACE MANNOSIDASE
    DAULAT TULSIANI; Fiscal Year: 2003
    ....
  28. Stigma & Quality of Life of Youth w/Facial Differences
    Donald Patrick; Fiscal Year: 2005
    ..Participants for this study will be recruited from sites in Seattle, Chicago, and Chapel Hill, NC. ..
  29. STRUCTURE/FUNCTION OF ZONA PELLUCIDA GLYCOPROTEINS
    DAULAT TULSIANI; Fiscal Year: 2001
    ....
  30. Chronic Prostatitis Collaborative Research Network CPCRN
    J Nickel; Fiscal Year: 2007
    ..Nickel as PI has the experience, expertise and the proven ability to design, implement and enroll patients with CPPS in clinical studies and will be a valuable partner in the proposed CPCRN and UCPPSCG. ..
  31. Mechanisms Causing Cryptorchidism and Fetal Transformation of Testicular Cells
    D N Rao Veeramachaneni; Fiscal Year: 2007
    ..Results will clarify the interaction of genetics and EDAs as cause of cryptorchidism. [unreadable] [unreadable] [unreadable]..
  32. Interstitial Cystitis Clinical Research Network (ICCRN)
    J Nickel; Fiscal Year: 2007
    ..site with Dr. Nickel as PI has the experience, expertise and the proven ability to design, implement and enroll patients with IC in clinical strudies and will be a valuable partner in the proposed ICCRN and UCPPSCG. ..
  33. Fetal Basis of Sexual Dysfunction: Brain Differentiation
    D N Rao Veeramachaneni; Fiscal Year: 2007
    ..By using a relevant and yet practical animal model the proposed studies will advance the knowledge base in pollutant-induced sexual/erectile dysfunction, an area pivotal to reproductive health/success in humans. [unreadable] [unreadable]..
  34. CHARACTERIZATION & TREATMENT OF CATEGORY III PROSTATITIS
    J Nickel; Fiscal Year: 2003
    ..Results from this 3 part study will be analyzed and correlated between groups and within groups, both concurrently and sequentially. ..
  35. NEUROPSYCHIATRIC EFFECTS OF TESTOSTERONE IN MEN
    Stuart Seidman; Fiscal Year: 2004
    ..abstract_text> ..
  36. NEURAL AND BEHAVIORAL ACTIONS OF ANABOLIC STEROIDS
    Ann Clark; Fiscal Year: 2003
    ....
  37. AAS and the Neurobiology of Social Behaviors
    Ann Clark; Fiscal Year: 2009
    ..Such data may be relevant towards understanding not only the effects of AAS, but of other abused drugs that act via GABAergic pathways. ..
  38. INDUCED ABORTION AND BREAST CANCER RISK
    De Kun Li; Fiscal Year: 2001
    ....
  39. Oral Androgen Administration and Function in Man
    JOHN AMORY; Fiscal Year: 2008
    ..Matsumoto M.D., Director, Clinical Research Unit VA-Puget Sound and Professor of Medicine, University of Washington School of Medicine will co-mentor this award. [unreadable] [unreadable]..
  40. Prenatal MF Exposure & Miscarriage Risk Among Women
    De Kun Li; Fiscal Year: 2009
    ..The findings from the proposed study will provide much needed confirmation of the recently reported results and advance our understanding of a MF health effect. ..
  41. 2008 AUA/SBUR Summer Research Conference
    Arthur Burnett; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  42. Androgenic And Antiandorgenic Interactions Of PC-SPES
    CHARLES ROSELLI; Fiscal Year: 2002
    ..Specific Aim 3: To evaluate the effect of PCSPES on Cytochrome P450-mediated metabolism of androgenic and antiandrogenic drugs by the liver, in order to identify possible interactions of PC-SPES with other hormone therapies. ..
  43. SECONDARY PREVENTION AMONG HIV POSITIVE ALCOHOL ABUSERS
    Jeffrey Parsons; Fiscal Year: 2001
    ..Participants will complete assessment batteries at intake, and at 1-week, 3, 6, 9, and 12 month follow-ups in order to assess short-term and long-term effects. ..
  44. Risk Reduction Intervention for Highly Vulnerable Emerging Adults Males
    Jeffrey T Parsons; Fiscal Year: 2010
    ..If effective, the intervention will help minimize the negative physical and psychological effects associated with club drug use, and reduce HIV infections among emerging adult males. ..
  45. Prevention of Depression in Patients Being Treated for Head and Neck Cancer
    William J Burke; Fiscal Year: 2010
    ..If successful, this approach may be applicable to other medical illnesses that have high rates of comorbid depression. ..
  46. Genetic Regulation of Mating Behavior in C. elegan Males
    Luis Garcia; Fiscal Year: 2009
    ..Additionally, this project will identify components of activating pathways that must be attenuated by unc-103 during periods between mating. ..
  47. NITRIC OXIDE REGULATORY SYSTEM IN THE PENIS
    Arthur Burnett; Fiscal Year: 2002
    ....
  48. Northeast Under/Grad Research Organization for Neuroscience
    Cheryl Frye; Fiscal Year: 2008
    ..Both of these outcomes are congruous with the Public Health Service's mission to ensure that there is a resource of well-trained scientists and health-care providers in the United States. [unreadable] [unreadable] [unreadable]..
  49. NEURAL MECHANISM MEDIATIING MALE BEHAVIOR
    Lique Coolen; Fiscal Year: 2004
    ..has demonstrated the existence of a neural subcircuit in the forebrain that is specifically related to ejaculation in male rats...
  50. Female sexuality: modulation by estrogen and androgen
    Kim Wallen; Fiscal Year: 2005
    ..These therapies will also be compared on their effects on neuroendocrine function. These studies will markedly increase our understanding of the role that ovarian steroids play in modulating women's sexuality. ..
  51. The Role of RET in Spermatogenesis
    Cathy Naughton; Fiscal Year: 2005
    ..The translation to human disease will be achieved by studying RET expression in male infertility cases of maturation arrest. ..
  52. Adherence Intervention for HIV + Alcohol Users
    Jeffrey Parsons; Fiscal Year: 2005
    ..Multivariate repeated measures analyses and growth curve modeling, using both continuous and dichotomous outcome variables, will be used to assess the impact of the intervention on both adherence and alcohol use. ..
  53. Volume-Outcomes in Incontinence Surgery
    Jennifer Anger; Fiscal Year: 2005
    ..The primary outcome will be re-operation rates, repeat sling procedures (for failures), and other postoperative complications, stratified by high and low volume surgeons and hospitals. ..
  54. BEHAVIORAL DEVELOPMENT--PRENATAL HORMONAL INFLUENCES
    Kim Wallen; Fiscal Year: 2002
    ..The combination of these efforts will allow the PI to expand his research into new areas, while increasing his understanding of its relevance to important human mental health conditions. ..
  55. Urodynamic and Multiethnic Variability of Men Treated b*
    Steven Kaplan; Fiscal Year: 2005
    ..Baseline urodynamic parameters which may predict improved outcome after MIST 3. The success of various types of MIST in treating BPH in African - American, Hispanic and Caucasian men. ..
  56. Patterns and Contexts of Club Drug Abuse
    Jeffrey Parsons; Fiscal Year: 2007
    ..Mixed-methods strategies will be used to examine the qualitative and quantitative data together in order to further understand the data and potential implications for intervention development. ..
  57. Exposure to Bisphenol A & Reproductive Effect in Humans
    De Kun Li; Fiscal Year: 2007
    ..The proposed study will evaluate the reproductive effects of BPA in settings where there have been high levels of exposure. The study will also investigate effects in multiple human generations. ..
  58. Development and Evaluation of a Group HIV Intervention for Gender Stigmatized Per
    Jeffrey Parsons; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  59. Neural Regulation of Ejaculation
    Lique Coolen; Fiscal Year: 2007
    ..However, the central control of ejaculation remains poorly understood...
  60. Prenatal NSAID Use and Miscarriage
    De Kun Li; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  61. CELL-SELECTIVE EXPRESSION OF FIBROTIC GENE PATHWAYS
    Nestor Gonzalez Cadavid; Fiscal Year: 2008
    ..We expect that our studies would lead to the detection of novel targets of antifibrotic therapy for penile and vascular diseases of considerable public health impact. [unreadable] [unreadable] [unreadable]..