parthenogenesis

Summary

Summary: A unisexual reproduction without the fusion of a male and a female gamete (FERTILIZATION). In parthenogenesis, an individual is formed from an unfertilized OVUM that did not complete MEIOSIS. Parthenogenesis occurs in nature and can be artificially induced.

Top Publications

  1. ncbi Genetic structure of an aphid studied using microsatellites: cyclic parthenogenesis, differentiated lineages and host specialization
    P Sunnucks
    School of Biological Sciences, Macquarie University, Sydney, NSW, Australia
    Mol Ecol 6:1059-73. 1997
  2. ncbi Derivation of human embryonic stem cell lines from parthenogenetic blastocysts
    Qingyun Mai
    1Reproductive Medical Center, the First Affiliated Hospital of SUMS University, Guangzhou 210029, China
    Cell Res 17:1008-19. 2007
  3. ncbi Birth of parthenogenetic mice that can develop to adulthood
    Tomohiro Kono
    Department of Bioscience, Tokyo University of Agriculture, Setagaya Ku, Tokyo 156 8502, Japan
    Nature 428:860-4. 2004
  4. ncbi L-carnitine enhances oocyte maturation and development of parthenogenetic embryos in pigs
    G Q Wu
    Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, People s Republic of China
    Theriogenology 76:785-93. 2011
  5. ncbi Anthocyanin stimulates in vitro development of cloned pig embryos by increasing the intracellular glutathione level and inhibiting reactive oxygen species
    Jinyoung You
    College of Veterinary Medicine, Kangwon National University, Chunchon, Korea
    Theriogenology 74:777-85. 2010
  6. ncbi Is polyploidy a persevering accident or an adaptive evolutionary pattern? The case of the brine shrimp Artemia
    Stefania Maniatsi
    Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Mol Phylogenet Evol 58:353-64. 2011
  7. ncbi Unisexual reproduction among vertebrates
    William B Neaves
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Trends Genet 27:81-8. 2011
  8. ncbi Multiple direct transitions from sexual reproduction to apomictic parthenogenesis in Timema stick insects
    Tanja Schwander
    Department of Biological Sciences, Simon Fraser University, Burnaby BC
    Evolution 63:84-103. 2009
  9. pmc Analysis of imprinted gene expression in normal fertilized and uniparental preimplantation porcine embryos
    Chi Hun Park
    SooAm Biotech Research Foundation, Seoul, Republic of Korea
    PLoS ONE 6:e22216. 2011
  10. ncbi Selection of low investment in sex in a cyclically parthenogenetic rotifer
    M J Carmona
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, 46071 Valencia, Spain
    J Evol Biol 22:1975-83. 2009

Detail Information

Publications326 found, 100 shown here

  1. ncbi Genetic structure of an aphid studied using microsatellites: cyclic parthenogenesis, differentiated lineages and host specialization
    P Sunnucks
    School of Biological Sciences, Macquarie University, Sydney, NSW, Australia
    Mol Ecol 6:1059-73. 1997
    ..The genotype group showing S. avenae-like as well as S. fragariae-like alleles also carried S. fragariae-like mitochondrial DNA in at least 25/31 cases, indicating gender-asymmetrical hybridization...
  2. ncbi Derivation of human embryonic stem cell lines from parthenogenetic blastocysts
    Qingyun Mai
    1Reproductive Medical Center, the First Affiliated Hospital of SUMS University, Guangzhou 210029, China
    Cell Res 17:1008-19. 2007
    b>Parthenogenesis is one of the main, and most useful, methods to derive embryonic stem cells (ESCs), which may be an important source of histocompatible cells and tissues for cell therapy...
  3. ncbi Birth of parthenogenetic mice that can develop to adulthood
    Tomohiro Kono
    Department of Bioscience, Tokyo University of Agriculture, Setagaya Ku, Tokyo 156 8502, Japan
    Nature 428:860-4. 2004
    Only mammals have relinquished parthenogenesis, a means of producing descendants solely from maternal germ cells. Mouse parthenogenetic embryos die by day 10 of gestation...
  4. ncbi L-carnitine enhances oocyte maturation and development of parthenogenetic embryos in pigs
    G Q Wu
    Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, People s Republic of China
    Theriogenology 76:785-93. 2011
    ....
  5. ncbi Anthocyanin stimulates in vitro development of cloned pig embryos by increasing the intracellular glutathione level and inhibiting reactive oxygen species
    Jinyoung You
    College of Veterinary Medicine, Kangwon National University, Chunchon, Korea
    Theriogenology 74:777-85. 2010
    ....
  6. ncbi Is polyploidy a persevering accident or an adaptive evolutionary pattern? The case of the brine shrimp Artemia
    Stefania Maniatsi
    Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Mol Phylogenet Evol 58:353-64. 2011
    ..b>Parthenogenesis itself and/or polyploidy are responsible for the maintenance and spread of clones in Artemia, a sexual-..
  7. ncbi Unisexual reproduction among vertebrates
    William B Neaves
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Trends Genet 27:81-8. 2011
    ..More than 80 taxa of fish, amphibians, and reptiles are now known to reproduce by parthenogenesis (Greek for 'virgin birth') or its variants, and they persist in nature as all-female lineages...
  8. ncbi Multiple direct transitions from sexual reproduction to apomictic parthenogenesis in Timema stick insects
    Tanja Schwander
    Department of Biological Sciences, Simon Fraser University, Burnaby BC
    Evolution 63:84-103. 2009
    Transitions from sexual reproduction to parthenogenesis may occur along multiple evolutionary pathways and involve various cytological mechanisms to produce diploid eggs...
  9. pmc Analysis of imprinted gene expression in normal fertilized and uniparental preimplantation porcine embryos
    Chi Hun Park
    SooAm Biotech Research Foundation, Seoul, Republic of Korea
    PLoS ONE 6:e22216. 2011
    ..In addition we believe that imprinted expression occurs in at least four genes, namely H19, IGF2, XIST and PEG10 in porcine blastocyst stage embryos...
  10. ncbi Selection of low investment in sex in a cyclically parthenogenetic rotifer
    M J Carmona
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, 46071 Valencia, Spain
    J Evol Biol 22:1975-83. 2009
    ....
  11. ncbi Characterization of a 'Bacteroidetes' symbiont in Encarsia wasps (Hymenoptera: Aphelinidae): proposal of 'Candidatus Cardinium hertigii'
    Einat Zchori-Fein
    Department of Vegetable Crops, Agricultural Research Organization, Newe Ya ar Research Center, Ramat Yishay, 30095, Israel
    Int J Syst Evol Microbiol 54:961-8. 2004
    ..lineage is associated with a number of diverse host reproductive manipulations, including induction of parthenogenesis in several Encarsia parasitoid wasps (Hymenoptera: Aphelinidae)...
  12. ncbi Shifting from clonal to sexual reproduction in aphids: physiological and developmental aspects
    Gael Le Trionnaire
    INRA Rennes, Agrocampus Rennes, Universite Rennes 1, UMR 1099 BiO3P Biology of Organisms and Populations Applied to Plant Protection, BP 35327, F 35653 Le Rheu, France
    Biol Cell 100:441-51. 2008
    ..As a result of the recent development of genomic resources in aphids, we expect these species will permit major advances in the study of the genomic basis underlying the choice of developmental fate and multiple reproduction strategies...
  13. ncbi Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs
    W H Colledge
    Wellcome CRC Institute of Cancer, University of Cambridge, UK
    Nature 370:65-8. 1994
    ..Mutant females also develop ovarian cysts. These results demonstrate that a major role for pp39mos is to prevent the spontaneous parthenogenetic activation of unfertilized eggs...
  14. pmc Thelytokous parthenogenesis in the fungus-gardening ant Mycocepurus smithii (Hymenoptera: Formicidae)
    Christian Rabeling
    Section of Integrative Biology, The University of Texas at Austin, Austin, Texas, USA
    PLoS ONE 4:e6781. 2009
    ..For a Portuguese translation of the abstract, please see Abstract S1...
  15. ncbi Monoallelic expression of nine imprinted genes in the sheep embryo occurs after the blastocyst stage
    Alexandra Thurston
    Wolfson Centre for Stem Cells, Tissue Engineering and Modelling, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG2 2RD, UK
    Reproduction 135:29-40. 2008
    ..Thus, for the majority of ovine imprinted genes examined, monoallelic expression does not occur until after the blastocyst stage...
  16. ncbi Effects of caffeine treatment on aged porcine oocytes: parthenogenetic activation ability, chromosome condensation and development to the blastocyst stage after somatic cell nuclear transfer
    Masaki Iwamoto
    Prime Tech Ltd, National Institute of Agrobiological Sciences, Tsuchiura, Ibaraki 300 0841, Japan
    Zygote 13:335-45. 2005
    ....
  17. ncbi Life-history changes that accompany the transition from sexual to parthenogenetic reproduction in Drosophila mercatorum
    M G Kramer
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Evolution 55:748-61. 2001
    ..costs of sex, most natural populations maintain sexual reproduction, even those capable of facultative parthenogenesis. Unfertilized eggs from natural populations of Drosophila mercatorum occasionally develop into viable adults, ..
  18. ncbi The maintenance of sex, clonal dynamics, and host-parasite coevolution in a mixed population of sexual and asexual snails
    Jukka Jokela
    1EAWAG, Swiss Federal Institute of Aquatic Science and Technology, Uberlandstrasse 133, 8600 Dubendorf, Switzerland
    Am Nat 174:S43-53. 2009
    ..These results are consistent with the Red Queen hypothesis and show that the coevolutionary dynamics predicted by the theory may also favor sexual reproduction in natural populations...
  19. ncbi Genomic imprinting is a barrier to parthenogenesis in mammals
    T Kono
    Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan
    Cytogenet Genome Res 113:31-5. 2006
    Only mammals have relinquished parthenogenesis as a means of producing descendants...
  20. ncbi Defined system for in vitro production of porcine embryos using a single basic medium
    Koji Yoshioka
    National Institute of Animal Health, Tsukuba, Japan
    J Reprod Dev 54:208-13. 2008
    ..These results demonstrate that porcine blastocysts can be produced by the defined system using a single basic medium...
  21. ncbi Geographic parthenogenesis and the common tea-tree stick insect of New Zealand
    Mary Morgan-Richards
    Ecology Group, Allan Wilson Center for Molecular Ecology and Evolution, INR, Massey University, Palmerston North, New Zealand
    Mol Ecol 19:1227-38. 2010
    ..Many parthenogenetic stick insects show the distribution pattern known as geographic parthenogenesis, in that they occupy habitats that are at higher altitude or latitude compared with their sexual relatives...
  22. ncbi A mite species that consists entirely of haploid females
    A R Weeks
    Institute for Biodiversity and Ecosystem Dynamics, Sections Population Biology and Evolutionary Biology, University of Amsterdam, 1098 SM Amsterdam, Netherlands
    Science 292:2479-82. 2001
    ..We show that this reproductive anomaly is caused by infection by an undescribed endosymbiotic bacterium, which results in feminization of haploid genetic males...
  23. ncbi Nuclear reprogramming: the strategy used in normal development is also used in somatic cell nuclear transfer and parthenogenesis
    Tianlong Gao
    Program for Graduation Studies, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Cell Res 17:135-50. 2007
    Somatic cell nuclear transfer (SCNT) and parthenogenesis are alternative forms of reproduction and development, building new life cycles on differentiated somatic cell nuclei and duplicated maternal chromatin, respectively...
  24. ncbi DNA evidence for nonhybrid origins of parthenogenesis in natural populations of vertebrates
    Elizabeth A Sinclair
    Botanic Gardens and Parks Authority and Department of Plant Biology, The University of Western Australia, West Perth, 6005, Western Australia, Australia
    Evolution 64:1346-57. 2010
    ..1% of all vertebrate species. Among vertebrates, true parthenogenesis is known only in squamate reptiles...
  25. pmc The genetics of obligate parthenogenesis in an aphid species and its consequences for the maintenance of alternative reproductive modes
    C A Dedryver
    INRA, UMR 1349 Institut de Génétique, Environnement et Protection des Plantes, Domaine de la Motte 35653, Le Rheu, France
    Heredity (Edinb) 110:39-45. 2013
    ..It also allows asexuality-inducing alleles to be protected locally during harsh winters when extreme frost kills most OP, and then to spread very quickly after winter...
  26. ncbi Adding complexity to the complex: new insights into the phylogeny, diversification and origin of parthenogenesis in the Aporrectodea caliginosa species complex (Oligochaeta, Lumbricidae)
    Rosa Fernandez
    Departamento de Zoología y Antropología Física, Facultad de Biologia, Universidad Complutense de Madrid, Calle José Antonio Nováis 2, 28040 Madrid, Spain
    Mol Phylogenet Evol 64:368-79. 2012
    ..05-3.48 Mya, respectively), thus implying the existence not only of at least two different moments in which parthenogenesis arose within this complex of species, but also of two different and independent evolutionary lines...
  27. ncbi Developmental competence of porcine oocytes after in vitro maturation and in vitro culture under different oxygen concentrations
    Jung Taek Kang
    Department of Theriogenology and Biotechnology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 151 742, Korea
    Zygote 20:1-8. 2012
    ..05) but not blastocyst quality...
  28. ncbi Parthenogenetic activation of rhesus monkey oocytes and reconstructed embryos
    S M Mitalipov
    Oregon Regional Primate Research Center, Beaverton, Oregon 97006, USA
    Biol Reprod 65:253-9. 2001
    ....
  29. ncbi Timing of first embryonic cleavage is a positive indicator of the in vitro developmental potential of porcine embryos derived from in vitro fertilization, somatic cell nuclear transfer and parthenogenesis
    S Clay Isom
    Division of Animal Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Mol Reprod Dev 79:197-207. 2012
    ....
  30. ncbi Effects of activation methods and culture conditions on development of parthenogenetic porcine embryos
    Laszlo Nanassy
    Department of Animal Breeding Science, Center of Agricultural Sciences, University of Debrecen, Böszörményi Street 138, Debrecen, Hungary
    Anim Reprod Sci 104:264-74. 2008
    ..The data also imply that the PZM-3 medium provides for enhanced culture conditions for the early development of parthenogenetic porcine embryos than NCSU-23...
  31. ncbi Hollow fiber vitrification: a novel method for vitrifying multiple embryos in a single device
    Hitomi Matsunari
    Laboratory of Developmental Engineering, Department of Life Sciences, School of Agriculture, Meiji University, Kawasaki 214 8571, Japan
    J Reprod Dev 58:599-608. 2012
    ..3%) piglets. These data demonstrate that the HFV method enables simultaneous vitrification of multiple embryos while still adhering to the MVC concept, and this new method is very effective for cryopreserving embryos of mice and pigs...
  32. ncbi Genome-wide gene expression profiling reveals aberrant MAPK and Wnt signaling pathways associated with early parthenogenesis
    Na Liu
    College of Life Sciences, Nankai University, Tianjin 300071, China
    J Mol Cell Biol 2:333-44. 2010
    Mammalian parthenogenesis could not survive but aborted during mid-gestation, presumably because of lack of paternal gene expression...
  33. pmc Natural interspecific and intraspecific horizontal transfer of parthenogenesis-inducing Wolbachia in Trichogramma wasps
    M E Huigens
    Laboratory of Entomology, Department of Plant Sciences, Wageningen University, PO Box 8031, 6700 EH Wageningen, The Netherlands
    Proc Biol Sci 271:509-15. 2004
    ..Here, we show natural inter- and intraspecific horizontal transfer of parthenogenesis-inducing Wolbachia between parasitoid wasps of the genus Trichogramma...
  34. pmc Equivalence of conventionally-derived and parthenote-derived human embryonic stem cells
    Julie V Harness
    Reeve Irvine Research Center, Sue and Bill Gross Stem Cell Research Center, Department of Anatomy and Neurobiology, School of Medicine, University of California at Irvine, Irvine, California, United States of America
    PLoS ONE 6:e14499. 2011
    ..The objective of this work was to determine points of equivalence and differences between conventionally-derived hESC and parthenote-derived hESC lines (phESC) in the undifferentiated state and during neural differentiation...
  35. ncbi Derivation of high-purity definitive endoderm from human parthenogenetic stem cells using an in vitro analog of the primitive streak
    Nikolay Turovets
    International Stem Cell Corporation, Oceanside, CA, USA
    Cell Transplant 21:217-34. 2012
    ....
  36. pmc Peg5/Neuronatin is an imprinted gene located on sub-distal chromosome 2 in the mouse
    F Kagitani
    Gene Research Center, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226, Japan
    Nucleic Acids Res 25:3428-32. 1997
    ..Peg5/Neuronatin maps to sub-distal Chr 2, proximal to the previously established imprinted region where imprinted genes cause abnormal shape and behavior in neonates...
  37. ncbi Contribution of cyclic parthenogenesis and colonization history to population structure in Daphnia
    Anne Thielsch
    Department of Ecology and Evolution, Goethe University Frankfurt am Main, Siesmayerstrasse 70, Frankfurt am Main, Germany
    Mol Ecol 18:1616-28. 2009
    Cyclic parthenogenesis, the alternation of parthenogenetic and sexual reproduction, can lead to a wide scope of population structures, ranging from almost monoclonal to genetically highly diverse populations...
  38. ncbi Patient-specific stem cell lines derived from human parthenogenetic blastocysts
    E S Revazova
    Lifeline Cell Technology, Walkersville, Maryland, USA
    Cloning Stem Cells 9:432-49. 2007
    ....
  39. ncbi Drosophila parthenogenesis: a model for de novo centrosome assembly
    Maria Giovanna Riparbelli
    University of Siena, Department of Evolutionary Biology, Via A Moro 4, I 53100 Siena, Italy
    Dev Biol 260:298-313. 2003
    ..We speculate that the release of the block preventing centrosome self-assembly could be a landmark for ensuring parthenogenetic reproduction...
  40. ncbi Rotation of meiotic spindle is controlled by microfilaments in mouse oocytes
    Zi Yu Zhu
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
    Biol Reprod 68:943-6. 2003
    ..These results indicate that spindle rotation is essential for polar body extrusion; it is the microfilaments that play a crucial role in regulating rotation of the meiotic spindle...
  41. pmc Meiosis genes in Daphnia pulex and the role of parthenogenesis in genome evolution
    Andrew M Schurko
    Roy J Carver Center for Comparative Genomics and Department of Biology, The University of Iowa, Iowa City, IA 52242, USA
    BMC Evol Biol 9:78. 2009
    ..However, little is understood about the molecular determinants of parthenogenesis. The Daphnia pulex genome must contain the molecular machinery for different reproductive modes: sexual (both ..
  42. ncbi The evolution of geographic parthenogenesis in Timema walking-sticks
    Jennifer H Law
    Department of Biosciences, Simon Fraser University, Burnaby, British Columbia, V5A 1S6 Canada
    Mol Ecol 11:1471-89. 2002
    ..studies of asexual lineages and their sexual progenitors are useful for inferring the causes of geographical parthenogenesis and testing hypotheses regarding the evolution of sex...
  43. ncbi The origin of centrosomes in parthenogenetic hymenopteran insects
    Patrick M Ferree
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Cruz, 95064, USA
    Curr Biol 16:801-7. 2006
    ..Accessory nuclei, therefore, may have played a significant role in the evolution of haplodiploidy in Hymenopteran insects...
  44. ncbi Rabbit embryonic stem cell lines derived from fertilized, parthenogenetic or somatic cell nuclear transfer embryos
    Zhen F Fang
    Center for Developmental Biology, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, 1665 Kong Jiang Road, Shanghai 200092, P R China
    Exp Cell Res 312:3669-82. 2006
    ..stem cells were isolated from rabbit blastocysts derived from fertilization (conventional rbES cells), parthenogenesis (pES cells) and nuclear transfer (ntES cells), and propagated in a serum-free culture system...
  45. ncbi Queen succession through asexual reproduction in termites
    Kenji Matsuura
    Laboratory of Insect Ecology, Graduate School of Environmental Science, Okayama University, Okayama 700 8530, Japan
    Science 323:1687. 2009
    ..We identified a previously unknown termite breeding system in which both parthenogenesis and sexual reproduction are conditionally used...
  46. pmc A bacterium targets maternally inherited centrosomes to kill males in Nasonia
    Patrick M Ferree
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Curr Biol 18:1409-14. 2008
    ..These findings reveal a novel mechanism of male killing in Nasonia, demonstrating that bacteria have evolved different mechanisms for inducing male killing in the Arthropods...
  47. ncbi Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality
    Ryuichi Ono
    Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kandasurugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Nat Genet 38:101-6. 2006
    ..This indicates that Peg10 is critical for mouse parthenogenetic development and provides the first direct evidence of an essential role of an evolutionarily conserved retrotransposon-derived gene in mammalian development...
  48. ncbi The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA
    K Schuster-Gossler
    Jackson Laboratory, Bar Harbor, Maine, USA
    Dev Dyn 212:214-28. 1998
    ..Gtl2 transcript levels are present in parthenogenic embryos but may be reduced, consistent with the pattern of inheritance of the Gtl2lacZ phenotype...
  49. ncbi Peg1/Mest imprinted gene on chromosome 6 identified by cDNA subtraction hybridization
    T Kaneko-Ishino
    Gene Research Center, Tokyo Institute of Technology, Yokohama, Japan
    Nat Genet 11:52-9. 1995
    b>Parthenogenesis in the mouse is embryonic lethal partly because of imprinted genes that are expressed only from the paternal genome...
  50. ncbi Parthenogenetic activation of oocytes in c-mos-deficient mice
    N Hashimoto
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Nature 370:68-71. 1994
    ..The results indicate that in mice Mos plays a role in the second meiotic metaphase arrest, but does not seem to be essential for the initiation of oocyte maturation, spermatogenesis or somatic cell cycle...
  51. ncbi Genetic architecture of sexual and asexual populations of the aphid Rhopalosiphum padi based on allozyme and microsatellite markers
    F Delmotte
    INRA, UMR INRA ENSAR Biologie des Organismes et des Populations appliquée à la Protection des Plantes, BP 35327, 35653 Le Rheu Cedex, France
    Mol Ecol 11:711-23. 2002
    ..Several widespread asexual genotypes were found to persist through time, as already seen in other aphid species, a feature seemingly consistent with the general-purpose genotype hypothesis...
  52. pmc Cell cycle-dependent regulation of structure of endoplasmic reticulum and inositol 1,4,5-trisphosphate-induced Ca2+ release in mouse oocytes and embryos
    Greg FitzHarris
    Department of Obstetrics and Gynaecology and the Assisted Conception Unit, University College London, London, WC1E 6BT
    Mol Biol Cell 14:288-301. 2003
    ....
  53. ncbi Ecology: Parthenogenesis in an outsider crayfish
    Gerhard Scholtz
    Humboldt Universitat zu Berlin, Institut für Biologie Vergleichende Zoologie, 10115 Berlin, Germany
    Nature 421:806. 2003
  54. ncbi Birth of parthenote mice directly from parthenogenetic embryonic stem cells
    Zhisheng Chen
    School of Life Science, Sun Yet Sen University, Guangzhou, China
    Stem Cells 27:2136-45. 2009
    ..This is the first demonstration that pESCs are capable of full-term development and can differentiate into all cell types and functional organs in the body...
  55. ncbi Juvenile hormone agonists affect the occurrence of male Daphnia
    Norihisa Tatarazako
    National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba City, Ibaraki 305 8506, Japan
    Chemosphere 53:827-33. 2003
    The water flea Daphnia magna reproduces primarily by cyclic parthenogenesis. Environmental stimuli that signal a change to adverse conditions induce the organisms to switch from parthenogenesis to gamogenetic reproduction...
  56. ncbi Global analysis of parental imprinting in human parthenogenetic induced pluripotent stem cells
    Yonatan Stelzer
    Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel
    Nat Struct Mol Biol 18:735-41. 2011
    ..Examination of the consequences of parthenogenesis on human development identified marked effects on the differentiation of extraembryonic trophectoderm and ..
  57. ncbi Evaluation of elevated ploidy and asexual reproduction as alternative explanations for geographic parthenogenesis in Eucypris virens ostracods
    Sofia Adolfsson
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Department of Aquatic Ecology, Uberlandstrasse 133, CH 8600 Dubendorf, Switzerland
    Evolution 64:986-97. 2010
    ....
  58. pmc Mapping and characterization of novel parthenocarpy QTLs in tomato
    Benoit Gorguet
    Graduate School of Experimental Plant Sciences, Wageningen UR Plant Breeding, 6700AJ, Wageningen, The Netherlands
    Theor Appl Genet 116:755-67. 2008
    ..This candidate gene approach may lead to the first isolation of a parthenocarpy gene in tomato and will allow further use in several crop species...
  59. pmc Parthenogenic blastocysts derived from cumulus-free in vitro matured human oocytes
    Sohyun L McElroy
    Center for Human Embryonic Stem Cell Research and Education, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Palo Alto, California, United States of America
    PLoS ONE 5:e10979. 2010
    ..We aimed to improve maturation conditions for cumulus-free oocytes via culture with ovarian paracrine/autocrine factors identified by single cell analysis...
  60. ncbi Disruption of parental-specific expression of imprinted genes in uniparental fetuses
    Hidehiko Ogawa
    Department of Bioscience, Tokyo University of Agriculture, 1 1 1 Sakuragaoka, Tokyo 156 8502, Japan
    FEBS Lett 580:5377-84. 2006
    ..These results suggest that mechanisms acting in trans between paternal and maternal alleles are involved in the appropriate expression of some imprinted genes...
  61. ncbi Exceptional cryptic diversity and multiple origins of parthenogenesis in a freshwater ostracod
    S N S Bode
    RBINS, Dept of Freshwater Biology, rue Vautier 29, 1000 Brussels, Belgium
    Mol Phylogenet Evol 54:542-52. 2010
    ..Although many transitions appear to be ancient, we argue that this may be an artefact of the existence of unsampled or extinct sexual lineages...
  62. ncbi Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice
    Naoko Yoshida
    Laboratory of Mammalian Molecular Embryology, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Development 134:3941-52. 2007
    ..Meiotic progression can also be triggered without sperm, as in parthenogenesis, although the classic mouse in vivo parthenogenetic model, LT/Sv, fails in meiosis I owing to an unknown ..
  63. ncbi Efficient strontium-induced activation of mouse oocytes in standard culture media by chelating calcium
    Satoshi Kishigami
    Center for Developmental Biology RIKEN Kobe, Kobe, Japan
    J Reprod Dev 53:1207-15. 2007
    ..Thus, addition of EGTA to typical Ca(2+)-containing culture media can easily produce activation media that does not interfere with embryonic development...
  64. ncbi Aster self-organization at meiosis: a conserved mechanism in insect parthenogenesis?
    Maria Giovanna Riparbelli
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 4, I 53100 Siena, Italy
    Dev Biol 278:220-30. 2005
    ..The appearance of microtubule asters at the surface of activated oocytes could represent a possible common mechanism for centrosome formation during insect parthenogenesis.
  65. ncbi Histocompatible embryonic stem cells by parthenogenesis
    Kitai Kim
    Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Science 315:482-6. 2007
    Genetically matched pluripotent embryonic stem (ES) cells generated via nuclear transfer or parthenogenesis (pES cells) are a potential source of histocompatible cells and tissues for transplantation...
  66. doi Recombination signatures distinguish embryonic stem cells derived by parthenogenesis and somatic cell nuclear transfer
    Kitai Kim
    Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell Stem Cell 1:346-52. 2007
    b>Parthenogenesis and somatic cell nuclear transfer (SCNT) are two methods for deriving embryonic stem (ES) cells that are genetically matched to the oocyte donor or somatic cell donor, respectively...
  67. ncbi A new case of Wolbachia dependence in the genus Asobara: evidence for parthenogenesis induction in Asobara japonica
    N Kremer
    Universite de Lyon, F 69000, Lyon, France
    Heredity (Edinb) 103:248-56. 2009
    ..However, they produced only sons, showing that wAjap induces thelytokous parthenogenesis. Analyses of mating behavior and offspring production of individuals from Wolbachia-infected populations ..
  68. ncbi A highly homozygous and parthenogenetic human embryonic stem cell line derived from a one-pronuclear oocyte following in vitro fertilization procedure
    Ge Lin
    Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha 410078, China
    Cell Res 17:999-1007. 2007
    ....
  69. ncbi Cytology of Wolbachia-induced parthenogenesis in Leptopilina clavipes (Hymenoptera: Figitidae)
    Bart A Pannebakker
    Section of Animal Ecology, Institute of Biology, Leiden University, The Netherlands
    Genome 47:299-303. 2004
    b>Parthenogenesis induced by cytoplasmatically inherited Wolbachia bacteria has been found in a number of arthropod species, mainly Hymenoptera...
  70. ncbi In vitro differentiation of human parthenogenetic stem cells into neural lineages
    Dmitry A Isaev
    International Stem Cell Corporation, Carlsbad, CA, USA
    Regen Med 7:37-45. 2012
    ..As parthenogenesis does not involve the destruction of a viable human embryo, the derivation and use of human parthenogenetic ..
  71. ncbi Asexuality alone does not explain the success of clonal forms in insects with geographical parthenogenesis
    Magnus Lundmark
    Department of Molecular Biology, Umea University, Sweden
    Hereditas 143:23-32. 2006
    ..Especially in insects, the pattern called geographical parthenogenesis shows that asexuality is important in speciation and ecological adaptation...
  72. ncbi Meiotic recombination dramatically decreased in thelytokous queens of the little fire ant and their sexually produced workers
    Olivier Rey
    INRA, UMR Centre de Biologie pour la Gestion des Populations INRA IRD CIRAD Montpellier SupAgro, Montferrier sur Lez CEDEX, France
    Mol Biol Evol 28:2591-601. 2011
    ..parthenogenetic queen lineages and compared these rates with theoretical expectations under various parthenogenesis mechanisms...
  73. ncbi A single locus determines thelytokous parthenogenesis of laying honeybee workers (Apis mellifera capensis)
    H M G Lattorff
    Institut fur Zoologie, Molekulare Okologie, Martin Luther Universitat Halle Wittenberg, Hoher Weg 4, D 06099 Halle Saale, Germany
    Heredity (Edinb) 94:533-7. 2005
    ..to restore diploidy are well studied, the underlying genes that cause the switch from sexual reproduction to parthenogenesis have not been analysed...
  74. ncbi Reproduction in Strongyloides (Nematoda): a life between sex and parthenogenesis
    A Streit
    Max Planck Institute for Developmental Biology, Department IV, Evolutionary Biology, Spemannstrasse 37, D 72076 Tubingen, Germany
    Parasitology 135:285-94. 2008
    ....
  75. ncbi Hybridogenesis through thelytokous parthenogenesis in two Cataglyphis desert ants
    P A Eyer
    Evolutionary Biology and Ecology, Universite Libre de Bruxelles, 50, Av F D Roosevelt, CP 160 12, B 1050 Brussels, Belgium
    Mol Ecol 22:947-55. 2013
    ..are sexually produced hybridogens, whereas sexual forms (new queens and males) are produced by queens through parthenogenesis. Thus, only maternal genes are perpetuated across generations...
  76. ncbi Proteomic analysis of parthenogenetic and in vitro fertilized porcine embryos
    Mukesh Kumar Gupta
    Department of Animal Biotechnology, Bio Organ Research Center, Konkuk University, Hwayang dong, Gwangjin gu, Seoul, South Korea
    Proteomics 9:2846-60. 2009
    ..To our knowledge, this is the first report on global peptide sequencing and quantification of protein in PA and IVF embryos by LC-MS/MS that may be useful as a reference map for future studies...
  77. pmc Cheater genotypes in the parthenogenetic ant Pristomyrmex punctatus
    Shigeto Dobata
    Department of General Systems Studies, Graduate School of Arts and Sciences, University of Tokyo, Meguro, Tokyo 153 8902, Japan
    Proc Biol Sci 276:567-74. 2009
    ..some of these large-bodied individuals form a genetically distinct lineage, isolated from cooperators by parthenogenesis. A phylogenetic study confirmed that this cheater lineage originated intraspecifically...
  78. ncbi Thelytokous parthenogenesis in eusocial Hymenoptera
    Christian Rabeling
    Museum of Comparative Zoology Labs, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Entomol 58:273-92. 2013
    Female parthenogenesis, or thelytoky, is particularly common in solitary Hymenoptera. Only more recently has it become clear that many eusocial species also regularly reproduce thelytokously, and here we provide a comprehensive overview...
  79. pmc A successful crayfish invader is capable of facultative parthenogenesis: a novel reproductive mode in decapod crustaceans
    Milos Buric
    Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses and Research Institute of Fish Culture and Hydrobiology, University of South Bohemia in Èeské Budìjovice, Vodòany, Czech Republic
    PLoS ONE 6:e20281. 2011
    ..particularly widespread in Europe, the spiny-cheek crayfish Orconectes limosus, are capable of facultative parthenogenesis. Such reproductive mode has never before been recognized in decapods, the most diverse crustacean order...
  80. ncbi Development and quality of porcine embryos in different culture system and embryo-producing methods
    S A Ock
    Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Chinju, Republic of Korea
    Zygote 15:1-8. 2007
    ....
  81. pmc Intragenomic conflict in populations infected by Parthenogenesis Inducing Wolbachia ends with irreversible loss of sexual reproduction
    Richard Stouthamer
    Department of Entomology, University of California, Riverside, CA 92521, USA
    BMC Evol Biol 10:229. 2010
    The maternally inherited, bacterial symbiont, parthenogenesis inducing (PI) Wolbachia, causes females in some haplodiploid insects to produce daughters from both fertilized and unfertilized eggs...
  82. ncbi Population genetic structure, worker reproduction and thelytokous parthenogenesis in the desert ant Cataglyphis sabulosa
    I Timmermans
    Behavioural and Evolutionary Ecology, University of Brussels, Brussels, Belgium
    Heredity (Edinb) 101:490-8. 2008
    ..Here, we investigated population genetic structure, mating system, worker reproduction and parthenogenesis in the desert ant Cataglyphis sabulosa...
  83. ncbi Constraints on the evolution of asexual reproduction
    Jan Engelstädter
    Department of Integrative Biology, Swiss Federal Institute of Technology Zurich, Switzerland
    Bioessays 30:1138-50. 2008
    ..a long time? The present review approaches this question by considering factors that impede the evolution of parthenogenesis in animals. Most importantly, eggs need a diploid chromosome set in most species in order to develop normally...
  84. ncbi Molecular phylogeny, biogeography and insights into the origin of parthenogenesis in the Neotropical genus Leposoma (Squamata: Gymnophthalmidae): Ancient links between the Atlantic Forest and Amazonia
    Katia C M Pellegrino
    Departamento de Ciencias Biologicas, Universidade Federal de Sao Paulo, Avenida Professor Artur Riedel, 275, Jardim Eldorado, Diadema, CEP 09972 270, Sao Paulo, Brazil
    Mol Phylogenet Evol 61:446-59. 2011
    ..of parental species of the unisexual Leposoma percarinatum or the mechanism involved in the origin of parthenogenesis, but revealed two highly divergent diploid and triploid lineages within L...
  85. ncbi Haploid embryonic stem cells: an ideal tool for mammalian genetic analyses
    Linyu Shi
    Group of Epigenetic Reprogramming, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China
    Protein Cell 3:806-10. 2012
    ....
  86. pmc Facultative parthenogenesis discovered in wild vertebrates
    Warren Booth
    Department of Entomology and W M Keck Center for Behavioral Biology, North Carolina State University, PO Box 7613, Raleigh, NC 27695, USA
    Biol Lett 8:983-5. 2012
    Facultative parthenogenesis (FP)-asexual reproduction by bisexual species-has been documented in a variety of multi-cellular organisms but only recently in snakes, varanid lizards, birds and sharks...
  87. ncbi Establishment of the mammalian membrane block to polyspermy: evidence for calcium-dependent and -independent regulation
    Allison J Gardner
    Division of Reproductive Biology, Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Room W3606, 615 N Wolfe St, Maryland, USA
    Reproduction 133:383-93. 2007
    ..The membrane block to polyspermy in mammalian eggs is likely to be the culmination of multiple post-fertilization events that together modify the egg membrane's receptivity to sperm...
  88. pmc Wolbachia-mediated parthenogenesis in the predatory thrips Franklinothrips vespiformis (Thysanoptera: Insecta)
    N Arakaki
    Okinawa Prefectural Agricultural Experiment Station, Sakiyama, Naha, Okinawa 903 0814, Japan
    Proc Biol Sci 268:1011-6. 2001
    ..They cause thelytoky, which is a form of parthenogenesis in which females produce females without males, in hymenopteran insects...
  89. ncbi Perspective: maternal kin groups and the origins of asymmetric genetic systems-genomic imprinting, haplodiploidy, and parthenogenesis
    Benjamin B Normark
    Department of Plant, Soil, and Insect Sciences and Graduate Program in Organismic and Evolutionary Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Evolution 60:631-42. 2006
    ..In rare circumstances in which paternal gene products gain access to maternal physiology via a placenta, PSGE with greedy paternal gene expression can persist (e.g., in mammals)...
  90. ncbi Parthenogenesis in non-rodent species: developmental competence and differentiation plasticity
    T A L Brevini
    UniStem, Centre for Stem Cell Research, Laboratory of Biomedical Embryology, Universita degli Studi di Milano, Italy
    Theriogenology 77:766-72. 2012
    ..This form of reproduction, known as parthenogenesis, occurs spontaneously in a variety of lower organisms, but not in mammals...
  91. pmc Parthenogenesis-derived multipotent stem cells adapted for tissue engineering applications
    Chester J Koh
    Wake Forest Institute for Regenerative Medicine, Winston Salem, NC 27157, USA
    Methods 47:90-7. 2009
    ..b>Parthenogenesis, the process by which an egg can develop into an embryo in the absence of sperm, may be a potential source of ..
  92. ncbi The effect of 6-dimethylaminopurine (6-DMAP) and cycloheximide (CHX) on the development and chromosomal complement of sheep parthenogenetic and nuclear transfer embryos
    B Alexander
    Department of Biomedical Science, Ontario Veterinary College, University of Guelph, Ontario, Canada
    Mol Reprod Dev 73:20-30. 2006
    ..The study also highlighted the feasibility of using bovine X and Y chromosome specific painting probes in sheep embryos...
  93. ncbi Role of nonessential amino acids on porcine embryos produced by parthenogenesis or somatic cell nuclear transfer
    Mukesh Kumar Gupta
    Department of Animal Biotechnology, Bio Organ Research Center, Konkuk University, 1, Hwayang dong, Gwangjin gu, Seoul, South Korea
    Mol Reprod Dev 75:588-97. 2008
    ..Nonessential amino acids improve the yield and quality of cloned and parthenogenetic porcine embryos and modulate the expression of embryo survival related genes...
  94. ncbi On the track of the Red Queen: bark beetles, their nematodes, local climate and geographic parthenogenesis
    S Meirmans
    Department of Biology, University of Bergen, Bergen, Norway
    J Evol Biol 19:1939-47. 2006
    Geographic parthenogenesis has been explained as resulting from parasite pressure (Red Queen hypothesis): several studies have found high degrees of sexuals where the prevalence of parasites is high...
  95. ncbi Biological differences between in vitro produced bovine embryos and parthenotes
    Enrique Gomez
    Genética y Reproducción Animal, SERIDA, Asturias, Spain
    Reproduction 137:285-95. 2009
    ....
  96. ncbi Parthenogenic blastocysts cultured under in vivo conditions exhibit proliferation and differentiation expression genes similar to those of normal embryos
    C Naturil-Alfonso
    Instituto de Ciencia y Tecnología Animal, Universidad Politecnica de Valencia, Valencia 46022, Spain
    Anim Reprod Sci 127:222-8. 2011
    ..This is the first demonstration of the influence of culture conditions on parthenote mRNA expression. Our study highlights the importance of culture conditions in subsequent uses of parthenotes, such as the production of stem cell lines...
  97. ncbi Evolutionary implications of developmental instability in parthenogenetic drosophila mercatorum. I. Comparison of several strains with different genotypes
    Melissa G Kramer
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Evol Dev 4:223-33. 2002
    Natural populations of sexually reproducing Drosophila mercatorum are capable of a very low rate of parthenogenesis, but this mode of reproduction has apparently never characterized an entirely asexual population in this species...
  98. ncbi The non-viability of uniparental mouse conceptuses correlates with the loss of the products of imprinted genes
    C Walsh
    Institute for Experimental Drug Research, Karolinska Hospital, Stockholm, Sweden
    Mech Dev 46:55-62. 1994
    ..We discuss these observations with respect to the non-viability of uniparental conceptuses and the reciprocal imprinting patterns of the Igf2 and H19 genes...
  99. ncbi Effect of different parthenogenetic activation methods on the developmental competence of in vitro matured porcine oocytes
    Wen Min Cheng
    Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Sciences and Technology, China Agricultural University, Beijing, People s Republic of China
    Anim Biotechnol 18:131-41. 2007
    ..1 vs 25.3-27.2; P < 0.05). In conclusion, DC pulse, ethanol, CB, and 6-DMAP all affected the parthenogenesis of porcine oocytes matured in vitro, but their combination of DC pulse + CB + 6-DMAP showed the best result ..
  100. pmc Characterization of conserved and nonconserved imprinted genes in swine
    Steve R Bischoff
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, North Carolina 27606, USA
    Biol Reprod 81:906-20. 2009
    ..We also found no evidence of imprinting in ASB4, ASCL2, CD81, COMMD1, DCN, DLX5, and H13. Combined, these results represent the most comprehensive survey of imprinted genes in swine to date...
  101. ncbi Trematode infection and the distribution and dynamics of parthenogenetic snail populations
    C M Livel
    Department of Biology, Indiana University, Bloomington 47405 3700, USA
    Parasitology 123:S19-26. 2001
    ..I suggest that the theory is not sufficient, but that parasites in combination with mutation accumulation in clonal lines may explain the maintenance of sex in species that occasionally produce apomictic mutants...

Research Grants34

  1. The Control of Centriole Duplication and Degeneration
    Meng Fu Bryan Tsou; Fiscal Year: 2013
    ..cell polarity and asymmetric cell division, (iii) assembly of cilia and flagella, and (iv) suppression of parthenogenesis. In each case, strict control over centrosome biogenesis is required...
  2. Expression and evolution of chemoreceptor genes in the model organism Daphnia
    DINORA CAROLINA PENALVA ARANA; Fiscal Year: 2010
    ..As D. pulex clones can exhibit both cyclical parthenogenesis (ie...
  3. Single Centriole-Mediated Gynogenesis in the Zebrafish
    Francisco J Pelegri; Fiscal Year: 2012
    DESCRIPTION (provided by investigator): Parthenogenesis, the ability to generate viable diploid offspring from a single organism, allows the direct homozygosis (in a single generation) of alleles present in the heterozygous form in a ..
  4. Murine Models for Regenerative Medicine
    George Daley; Fiscal Year: 2009
    ..hematopoietic tissues derived from embryonic stem cells, including lines created by therapeutic cloning, parthenogenesis, and somatic cell reprogramming, can be harnessed to correct genetic bone marrow disorders in murine models...
  5. Genetic Control of Non-Autonomous Survival in Drosophila
    Andreas Bergmann; Fiscal Year: 2011
    ..between cells which are very relevant for tissue homeostasis, and abnormalities may be directly linked to the parthenogenesis of human diseases including cancer...
  6. Comparative phenotypic, functional, and molecular analysis of ESC and iPSC
    Peter J Park; Fiscal Year: 2010
    ..stem cells generated by direct reprogramming (miPSC) or isolated from embryos after fertilization (fESC), parthenogenesis (pESC), and somatic cell nuclear transfer (ntESC)...
  7. Characterization and genetic analysis of aging in Daphnia
    Jeffry L Dudycha; Fiscal Year: 2013
    ..Daphnia are freshwater microcrustaceans that reproduce through cyclic parthenogenesis, allowing laboratory investigators to generate thousands of genetically identical individuals easily...
  8. ANALYSIS OF CELL LINEAGE IN EMBRYOS
    Roger Pedersen; Fiscal Year: 1992
    ..Moreover, analysis of the extent of imprinting in marsupials by experimental induction of parthenogenesis should reveal the evolutionary origins and significance of imprinting...
  9. Synthetic Sugar Analogues to Probe the Function and Dynamics of Cell Wall Glycans
    MATTHEW BRIAN KRAFT; Fiscal Year: 2013
    ..The exact function of the arabinan in maintaining mycobacterial viability and parthenogenesis is not known, nor is how the specific structural characteristics of the arabinan contribute to its function...
  10. NOTCH SIGNALING REGULATES GRANULOSA CELL DIFFERENTIATION
    NORMA WILSON RAWLS; Fiscal Year: 2002
    ..result in unfertilizable eggs, so superovulation will be induced and eggs collected, and maturation tested by parthenogenesis using ionophore...
  11. Genetic dissection of parthenogenesis in the pea aphid
    Gregory Davis; Fiscal Year: 2006
    ..abstract_text> ..
  12. PATHOBIOLOGY OF PARTHENOGENESIS--MOLECULAR CONTROLS
    Drucilla Roberts; Fiscal Year: 1992
    b>Parthenogenesis is the biologic phenomenon whereby cell division and differentiation occurs following activation of an unfertilized gamete. This is a novel pathologic event where meiotic cells aberrantly enter mitosis...
  13. Discovery Craniofacial and Retinal Genes
    Charles Kimmel; Fiscal Year: 2005
    ..identified in highly efficient, directed, first generation (G1) screens, using embryos and larvae obtained by parthenogenesis and vitally stained with fluorescent dyes to reveal the phenotypes...
  14. VERTEBRATE MODEL OF DIFFERENTIATION/TUMOR SUPPRESSION
    Keith Cheng; Fiscal Year: 1999
    ..b>Parthenogenesis can be used to unmask recessive mutations within one generation in heterozygous parents...
  15. Genetic analysis of zebrafish circadian rhythmicity
    GREGORY CAHILL; Fiscal Year: 2006
    ..Early pressure" parthenogenesis will be used to reveal recessive mutations in a single generation and to produce mapping panels for ..
  16. A HISTOLOGIC SCREEN FOR CELL DIFFERENTIATION MUTANTS
    Keith Cheng; Fiscal Year: 2005
    ..the ability of this laboratory to perform all required steps in the proposed screen, including mutagenesis, parthenogenesis, histologic screening, and mapping...
  17. Genetics of Wing and Cell-Size Evolution in Nasonia
    John Werren; Fiscal Year: 2008
    ....
  18. Epigenetic Influences on Brain and Behavior
    David Crews; Fiscal Year: 2004
    ..Specific Aim III. To establish if the different behavioral profiles exhibited in such animals in adulthood are reflected in different patterns of activity in a network of interconnected limbic nuclei. ..
  19. Vector Population Modification Using Wolbachia Symbionts
    Stephen Dobson; Fiscal Year: 2006
    ..g., maternal transmission rates and Wolbachia effects on host fitness), simplifying discrimination between Culex infection types, and improving methods for field cage evaluation of Wolbachia control strategies. ..
  20. Eradication of a Primary Filariasis Vector Population at an Endemic Field Site
    STEPHEN LEONARD DOBSON; Fiscal Year: 2010
    ..Integration of the vector eradication strategy and the MDA approach will facilitate filariasis elimination in areas where MDA alone has failed. ..
  21. Role of Calcineurin in Fungal Virulence
    Joseph Heitman; Fiscal Year: 2009
    ..Importantly, this pathway can be targeted for therapeutic intervention using non-immunosuppressive calcineurin inhibitors that retain antifungal activity and synergistic drug combinations that we have discovered. ..
  22. Molecular Characterization of Parthenogenetic Meiosis
    DAYALAN SRINIVASAN; Fiscal Year: 2008
    ..These experiments represent the first step toward a molecular characterization of a dramatic example of adaptive plasticity in an ancient, highly conserved process. ..
  23. Reproduction of Transgenic Pigs by Nuclear Transplantation
    Randall S Prather; Fiscal Year: 2010
    ..The third aim is to determine the methylation profile and transcriptional profile of two different types of stem cells as compared to fetal-derived fibroblast-like cells. ..
  24. Genetics of mating and fruiting in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2010
    ..neoformans and C. gattii applicable to development of treatment approaches, diagnostics, or environmental interventions to reduce exposure to infectious spores. ..
  25. Genetic analysis of Cryptococcus neoformans virulence
    Joseph Heitman; Fiscal Year: 2009
    ..These studies will enable a genome-wide definition of the gene set contributing to virulence of this common human fungal pathogen. ..
  26. Oxidative Stress and Oocyte Development
    CATHERINE COMBELLES; Fiscal Year: 2007
    ..These findings will enhance our ability to detect and produce oocytes of optimal quality, thereby providing critical foundations for the improvement of female reproductive health. [unreadable] [unreadable] [unreadable]..
  27. GPCR signaling cascades in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. The molecular basis of morphological evolution
    David L Stern; Fiscal Year: 2010
    ..This detailed analysis of gene regulation promises to provide new insights into how gene regulation functions and evolves in natural species to cause possibly adaptive changes in morphology. ..
  29. Demographics and phylogeography of hybrid speciation
    JARED STRASBURG; Fiscal Year: 2007
    ..abstract_text> ..
  30. A Program for Expanding ELSI Undergraduate Pedagogy
    Ronald Green; Fiscal Year: 2005
    ..This proposal represents a logical next step in the employment of the skills and resources we have developed at Dartmouth for undergraduate ELSI education. ..
  31. EVOLUTION OF BRAIN-BEHAVIOR CONTROLLING MECHANISMS
    David Crews; Fiscal Year: 2009
    ..abstract_text> ..
  32. Regulation of capacitative calcium entry in porcine oocytes
    Zoltan Machaty; Fiscal Year: 2008
    ..By using the animals with specific genetic alterations it will be possible to better understand the mechanism of diseases and develop new and effective therapies. [unreadable] [unreadable] [unreadable]..
  33. TRAINING PROGRAM IN NEUROBIOLOGY AND BEHAVIOR
    David Crews; Fiscal Year: 2003
    ..All of the laboratories comply with NIH requirements. ..
  34. ENVIRONMENTAL INFLUENCES ON BRAIN PLASTICITY
    David Crews; Fiscal Year: 2002
    ..The final category of experiments is particularly important as it will discern whether the incubation temperature effects are direct or indirect. ..