Summary: The total process by which organisms produce offspring. (Stedman, 25th ed)

Top Publications

  1. pmc The genetics of Caenorhabditis elegans
    S Brenner
    Genetics 77:71-94. 1974
  2. pmc Evolution of pathogenicity and sexual reproduction in eight Candida genomes
    Geraldine Butler
    UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Nature 459:657-62. 2009
  3. ncbi Understanding the odd science of aging
    Thomas B L Kirkwood
    Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne NE4 6BE, United Kingdom
    Cell 120:437-47. 2005
  4. ncbi Evolution of genes and genomes on the Drosophila phylogeny
    Andrew G Clark
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 450:203-18. 2007
  5. ncbi The rapid evolution of reproductive proteins
    Willie J Swanson
    Department of Biology, University of California Riverside, Riverside, California 92521, USA
    Nat Rev Genet 3:137-44. 2002
  6. pmc Plant speciation
    Loren H Rieseberg
    Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Science 317:910-4. 2007
  7. pmc Kisspeptin signaling in the brain
    Amy E Oakley
    Department of Physiology and Biophysics, University of Washington, Box 356460, 1705 NE Pacific Street, Health Sciences Building Room BB604, Seattle, Washington 98195 6460, USA
    Endocr Rev 30:713-43. 2009
  8. ncbi In vitro molecular mechanisms of bisphenol A action
    Yelena B Wetherill
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Reprod Toxicol 24:178-98. 2007
  9. ncbi Oxidative stress as a mediator of life history trade-offs: mechanisms, measurements and interpretation
    Pat Monaghan
    Division of Ecology and Evolutionary Biology, Faculty of Biomedical and Life Sciences, Graham Kerr Building, University of Glasgow, Glasgow G128QQ, UK
    Ecol Lett 12:75-92. 2009
  10. ncbi Role of brain insulin receptor in control of body weight and reproduction
    J C Bruning
    Klinik II und Poliklinik für Innere Medizin and Center of Molecular Medicine ZMMK der Universität zu Köln, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Science 289:2122-5. 2000

Detail Information

Publications380 found, 100 shown here

  1. pmc The genetics of Caenorhabditis elegans
    S Brenner
    Genetics 77:71-94. 1974
    ..Mutations in 77 of these alter the movement of the animal. Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C. elegans are large...
  2. pmc Evolution of pathogenicity and sexual reproduction in eight Candida genomes
    Geraldine Butler
    UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Nature 459:657-62. 2009
    ..Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes...
  3. ncbi Understanding the odd science of aging
    Thomas B L Kirkwood
    Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne NE4 6BE, United Kingdom
    Cell 120:437-47. 2005
    ..factors such as hazard rates and food availability influence the trade-offs between investing in growth, reproduction, and somatic survival, explaining why species evolved different life spans and why aging rate can sometimes be ..
  4. ncbi Evolution of genes and genomes on the Drosophila phylogeny
    Andrew G Clark
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 450:203-18. 2007
    ..These may prove to underlie differences in the ecology and behaviour of these diverse species...
  5. ncbi The rapid evolution of reproductive proteins
    Willie J Swanson
    Department of Biology, University of California Riverside, Riverside, California 92521, USA
    Nat Rev Genet 3:137-44. 2002
    Many genes that mediate sexual reproduction, such as those involved in gamete recognition, diverge rapidly, often as a result of adaptive evolution...
  6. pmc Plant speciation
    Loren H Rieseberg
    Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Science 317:910-4. 2007
    ..differentiation, local dispersal, high fecundity, perennial life history, and self-fertilization or asexual reproduction. Finally, species richness in plants is correlated with many biological and geohistorical factors, most of ..
  7. pmc Kisspeptin signaling in the brain
    Amy E Oakley
    Department of Physiology and Biophysics, University of Washington, Box 356460, 1705 NE Pacific Street, Health Sciences Building Room BB604, Seattle, Washington 98195 6460, USA
    Endocr Rev 30:713-43. 2009
    ..product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged as key players in the regulation of reproduction. Mutations in humans or genetically targeted deletions in mice of either Kiss1 or Kiss1r cause profound ..
  8. ncbi In vitro molecular mechanisms of bisphenol A action
    Yelena B Wetherill
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Reprod Toxicol 24:178-98. 2007
  9. ncbi Oxidative stress as a mediator of life history trade-offs: mechanisms, measurements and interpretation
    Pat Monaghan
    Division of Ecology and Evolutionary Biology, Faculty of Biomedical and Life Sciences, Graham Kerr Building, University of Glasgow, Glasgow G128QQ, UK
    Ecol Lett 12:75-92. 2009
    ..We indicate throughout potentially fruitful areas for further research...
  10. ncbi Role of brain insulin receptor in control of body weight and reproduction
    J C Bruning
    Klinik II und Poliklinik für Innere Medizin and Center of Molecular Medicine ZMMK der Universität zu Köln, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Science 289:2122-5. 2000
    ..Thus, IR signaling in the CNS plays an important role in regulation of energy disposal, fuel metabolism, and reproduction.
  11. ncbi MHC studies in nonmodel vertebrates: what have we learned about natural selection in 15 years?
    L Bernatchez
    Department de Biologie, Universite Laval, Ste Foy, Quebec, Canada
    J Evol Biol 16:363-77. 2003
    ..We conclude this review by proposing several directions where future research is needed...
  12. pmc Running with the Red Queen: host-parasite coevolution selects for biparental sex
    Levi T Morran
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Science 333:216-8. 2011
    ..Thus, consistent with the Red Queen hypothesis, coevolving pathogens can select for biparental sex...
  13. ncbi Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat
    Yoshihiro Wakabayashi
    Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    J Neurosci 30:3124-32. 2010
    ..hormone (GnRH) neurons in the basal forebrain are the final common pathway through which the brain regulates reproduction. GnRH secretion occurs in a pulsatile manner, and indirect evidence suggests the kisspeptin neurons in the ..
  14. ncbi Why do females mate multiply? A review of the genetic benefits
    M D Jennions
    Smithsonian Tropical Research Institute, Balboa, Republic of Panama
    Biol Rev Camb Philos Soc 75:21-64. 2000
    ..Second, the role of multiple mating in promoting assortative fertilization and increasing reproductive isolation between populations may help us to understand sympatric speciation...
  15. pmc Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows
    John B Cole
    Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, Maryland, USA
    BMC Genomics 12:408. 2011
    ..Here, we report results of a genome-wide analysis of predicted transmitting ability (PTA) of 31 production, health, reproduction and body conformation traits in contemporary Holstein cows.
  16. pmc High-throughput sequencing to reveal genes involved in reproduction and development in Bactrocera dorsalis (Diptera: Tephritidae)
    Weiwei Zheng
    State Key Laboratory of Agricultural Microbiology, and Institute of Urban and Horticultural Pests, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, People s Republic of China
    PLoS ONE 7:e36463. 2012
    ..To facilitate molecular research into reproduction and development mechanisms, and finally effective control on these pests, an extensive transcriptome for the ..
  17. ncbi Genome-wide association studies of female reproduction in tropically adapted beef cattle
    R J Hawken
    Cooperative Research Centre for Beef Genetic Technologies, University of New England, Armidale, New South Wales 2351, Australia
    J Anim Sci 90:1398-410. 2012
    The genetics of reproduction is poorly understood because the heritabilities of traits currently recorded are low...
  18. ncbi Climate change and population declines in a long-distance migratory bird
    Christiaan Both
    Netherlands Institute of Ecology NIOO KNAW, PO Box 40, 6666ZG Heteren, The Netherlands
    Nature 441:81-3. 2006
    ..Mistiming as a result of climate change is probably a widespread phenomenon, and here we provide evidence that it can lead to population declines...
  19. pmc The effects of oxidative stress on female reproduction: a review
    Ashok Agarwal
    Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA
    Reprod Biol Endocrinol 10:49. 2012
  20. pmc Evolution in the fast lane: rapidly evolving sex-related genes in Drosophila
    Wilfried Haerty
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Genetics 177:1321-35. 2007
    ..portion of the annotated genes in Drosophila melanogaster show sex-biased expression, indicating that sex and reproduction-related genes (SRR genes) represent an appreciable component of the genome...
  21. pmc Meeting report: atmospheric pollution and human reproduction
    Remy Slama
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Environ Health Perspect 116:791-8. 2008
    ..There is a growing body of epidemiologic literature reporting associations between atmospheric pollutants and reproductive outcomes, particularly birth weight and gestational duration...
  22. ncbi Life-history trade-offs favour the evolution of animal personalities
    Max Wolf
    Theoretical Biology Group, Centre for Ecological and Evolutionary Studies, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
    Nature 447:581-4. 2007
    ..Our argument is based on the insight that the trade-off between current and future reproduction often results in polymorphic populations in which some individuals put more emphasis on future fitness returns ..
  23. ncbi Intralocus sexual conflict
    Russell Bonduriansky
    Evolution and Ecology Research Centre and School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Trends Ecol Evol 24:280-8. 2009
    ..Whereas recent thinking has focussed on the role of intralocus sexual conflict as a brake on sexual coevolution, we urge a broader appraisal that also takes account of its potential to drive adaptive evolution and speciation...
  24. ncbi Genetic effects of captive breeding cause a rapid, cumulative fitness decline in the wild
    Hitoshi Araki
    Department of Zoology, 3029 Cordley Hall, Oregon State University Corvallis, OR 97331, USA
    Science 318:100-3. 2007
    ..These results suggest that even a few generations of domestication may have negative effects on natural reproduction in the wild and that the repeated use of captive-reared parents to supplement wild populations should be ..
  25. ncbi Discovery of a sexual cycle in the opportunistic fungal pathogen Aspergillus fumigatus
    Céline M O'Gorman
    UCD School of Biology and Environmental Science, University College Dublin, Belfield, Dublin 4, Ireland
    Nature 457:471-4. 2009
    ..The ability of A. fumigatus to engage in sexual reproduction is highly significant in understanding the biology and evolution of the species...
  26. ncbi Evidence for ecological speciation and its alternative
    Dolph Schluter
    Biodiversity Research Centre and Zoology Department, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Science 323:737-41. 2009
    ..However, we still have not identified all aspects of selection, and identifying the underlying genes for reproductive isolation remains challenging...
  27. pmc Rethinking the evolutionary theory of aging: transfers, not births, shape senescence in social species
    Ronald D Lee
    Department of Demography, University of California, 2232 Piedmont Avenue, Berkeley, CA 94720 2120, USA
    Proc Natl Acad Sci U S A 100:9637-42. 2003
    ..However, successful reproduction often involves intergenerational transfers as well as fertility...
  28. ncbi TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction
    A Kemal Topaloglu
    Cukurova University, Faculty of Medicine, Department of Pediatric Endocrinology and Metabolism, Balcali, Adana 01330, Turkey
    Nat Genet 41:354-8. 2009
    ..These findings implicate Neurokinin B as a critical central regulator of human gonadal function and suggest new approaches to the pharmacological control of human reproduction and sex hormone-related diseases.
  29. pmc Effect of insecticide resistance on development, longevity and reproduction of field or laboratory selected Aedes aegypti populations
    Ademir Jesus Martins
    Laboratório de Fisiologia e Controle de Artrópodes Vetores, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil
    PLoS ONE 7:e31889. 2012
  30. pmc Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution
    Peter Parham
    Department of Structural Biology, Stanford University, Stanford, California 94305, USA
    Nat Rev Immunol 13:133-44. 2013
    Natural killer (NK) cells have roles in immunity and reproduction that are controlled by variable receptors that recognize MHC class I molecules...
  31. pmc Acetylesterase-mediated deacetylation of pectin impairs cell elongation, pollen germination, and plant reproduction
    Jin Ying Gou
    Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Plant Cell 24:50-65. 2012
  32. ncbi Evolution of fungal sexual reproduction
    Joseph Heitman
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA
    Mycologia 105:1-27. 2013
    ..advances in our understanding of the genetic, molecular and genomic basis of sex determination and sexual reproduction in the fungal kingdom as a window on the evolution of sex in eukaryotes more generally...
  33. ncbi High local genetic diversity and low outcrossing rate in Caenorhabditis elegans natural populations
    Antoine Barrière
    Institut Jacques Monod, Centre National de la Recherche Scientifique, Universities Paris 6 and 7, Paris, France
    Curr Biol 15:1176-84. 2005
    ..In particular, its unusual mode of reproduction with self-fertile hermaphrodites and facultative males raises the question of its frequency of outcrossing in ..
  34. ncbi Genes and speciation
    Chung I Wu
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Nat Rev Genet 5:114-22. 2004
  35. ncbi The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins--roles in reproduction, cancer, and immune defense
    Gerard M Gibbs
    Monash Institute of Medical Research, Monash University, 27 31 Wright Street, Clayton 3168, Australia
    Endocr Rev 29:865-97. 2008
  36. ncbi Cost of mating in Drosophila melanogaster females is mediated by male accessory gland products
    T Chapman
    ICAPB, University of Edinburgh, UK
    Nature 373:241-4. 1995
    ..The cost of mating to females may therefore represent a side-effect of evolutionary conflict between males...
  37. ncbi Kisspeptins and reproduction: physiological roles and regulatory mechanisms
    Leonor Pinilla
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Spain
    Physiol Rev 92:1235-316. 2012
    ..neuronal networks have evolved to mediate the diverse internal and external environmental inputs that regulate reproduction in vertebrates...
  38. ncbi Rapid evolution of reproductive barriers driven by sexual conflict
    S Gavrilets
    Department of Ecology and Evolutionary Biology, University of Tennessee, Knoxville 37996 1610, USA
    Nature 403:886-9. 2000
    ..evolutionary novelty that appears to be acting on fertilization systems seems paradoxical because successful reproduction requires the close matching of female and male traits...
  39. ncbi Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans
    Daniel L Motola
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Cell 124:1209-23. 2006
    ..define the first steroid hormones in nematodes as ligands for an invertebrate orphan nuclear receptor and demonstrate that steroidal regulation of reproduction, from biology to molecular mechanism, is conserved from worms to humans.
  40. pmc Homothallic and heterothallic mating in the opportunistic pathogen Candida albicans
    Kevin Alby
    Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island 02912, USA
    Nature 460:890-3. 2009
    ..Furthermore, Bar1 protease has an unexpected but pivotal role in determining whether sexual reproduction can potentially be homothallic or is exclusively heterothallic...
  41. ncbi A rapidly evolving homeobox at the site of a hybrid sterility gene
    C T Ting
    Department of Ecology and Evolution, The University of Chicago, Chicago, IL 60637, USA
    Science 282:1501-4. 1998
    ..Such rapid sequence divergence is driven by positive selection and may contribute to reproductive isolation...
  42. pmc Transmission of Hypervirulence traits via sexual reproduction within and between lineages of the human fungal pathogen cryptococcus gattii
    Kerstin Voelz
    Institute of Microbiology and Infection and School of Biosciences, University of Birmingham, Birmingham, United Kingdom The National Institute of Health Research Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom
    PLoS Genet 9:e1003771. 2013
    ..gattii lineages VGII and VGIII, potentially creating novel hypervirulent genotypes, and that current models of uniparental mitochondrial inheritance in the Cryptococcus genus may not be universal. ..
  43. ncbi Disruption of zebrafish (Danio rerio) reproduction upon chronic exposure to TiO₂ nanoparticles
    Jiangxin Wang
    Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ, USA
    Chemosphere 83:461-7. 2011
    ..1 mg L(-1) nTiO(2), can significantly impair zebrafish reproduction. For instance, there was a 29...
  44. pmc TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance
    Shijing Luo
    Lewis Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cell 143:299-312. 2010
    Reproductive cessation is perhaps the earliest aging phenotype that humans experience. Similarly, reproduction of Caenorhabditis elegans ceases in mid-adulthood...
  45. ncbi STAT3 signalling is required for leptin regulation of energy balance but not reproduction
    Sarah H Bates
    Research Division, Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, Massachusetts 02215, USA
    Nature 421:856-9. 2003
    ..LRb-STAT3 signalling thus mediates the effects of leptin on melanocortin production and body energy homeostasis, whereas distinct LRb signals regulate NPY and the control of fertility, growth and glucose homeostasis...
  46. ncbi White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient mating
    Mathew G Miller
    Department of Microbiology and Immunology, University of California, San Francisco 94143, USA
    Cell 110:293-302. 2002
    ..As white cells are generally more robust in a mammalian host than are opaque cells, this strategy allows the organism to survive the rigors of life within a mammalian host, yet generate mating-competent cells...
  47. ncbi Severe intergenerational reproductive conflict and the evolution of menopause
    Mirkka Lahdenperä
    Section of Ecology, Department of Biology, University of Turku, Turku, Finland
    Ecol Lett 15:1283-90. 2012 remains an evolutionary puzzle: studies have largely failed to account for diminishing selection on reproduction beyond 50 years...
  48. ncbi Selection on heritable phenotypic plasticity in a wild bird population
    Daniel H Nussey
    Netherlands Institute of Ecology NIOO KNAW, Post Office Box 40, 6666 ZG Heteren, Netherlands
    Science 310:304-6. 2005
    ..from a Dutch population of great tits (Parus major) for variation in individual plasticity in the timing of reproduction, and we show that this variation is heritable...
  49. ncbi Interference of endocrine disrupting chemicals with aromatase CYP19 expression or activity, and consequences for reproduction of teleost fish
    Ksenia Cheshenko
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Ueberlandstrasse 133, Postfach 611, CH 8600 Dubendorf, Switzerland
    Gen Comp Endocrinol 155:31-62. 2008
    ..A decrease in reproduction success is one of the most well-documented signs of endocrine disruption in fish...
  50. pmc Genetic circuits that govern bisexual and unisexual reproduction in Cryptococcus neoformans
    Marianna Feretzaki
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Genet 9:e1003688. 2013
    ..Sexual reproduction involves cells of either opposite (bisexual) or one (unisexual) mating type...
  51. ncbi Oxidative stress-related PMK-1 P38 MAPK activation as a mechanism for toxicity of silver nanoparticles to reproduction in the nematode Caenorhabditis elegans
    Dongyoung Lim
    School of Environmental Engineering, Graduate School of Energy and Environment Systems Engineering, University of Seoul, Seoul, Korea
    Environ Toxicol Chem 31:585-92. 2012
    ..was investigated in the nematode, Caenorhabditis elegans, focusing on the involvement of oxidative stress in reproduction toxicity...
  52. pmc Estimating genetic parameters in natural populations using the "animal model"
    Loeske E B Kruuk
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    Philos Trans R Soc Lond B Biol Sci 359:873-90. 2004
  53. ncbi Estimating genetic benefits of polyandry from experimental studies: a meta-analysis
    Rachel A Slatyer
    Evolution, Ecology and Genetics, Research School of Biology, The Australian National University, Canberra, Australia
    Biol Rev Camb Philos Soc 87:1-33. 2012
  54. ncbi The influence of social hierarchy on primate health
    Robert M Sapolsky
    Departments of Biological Sciences, Neurology and Neurological Sciences, Stanford University, MC 5020, Stanford, CA 94305 5020, USA
    Science 308:648-52. 2005
    ..Finally, I consider how these findings apply to the human realm of health, disease, and socioeconomic status...
  55. pmc Discovery of a phenotypic switch regulating sexual mating in the opportunistic fungal pathogen Candida tropicalis
    Allison M Porman
    Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 108:21158-63. 2011
    Sexual reproduction can promote genetic diversity in eukaryotes, and yet many pathogenic fungi have been labeled as obligate asexual species...
  56. ncbi MHC-dependent survival in a wild population: evidence for hidden genetic benefits gained through extra-pair fertilizations
    Lyanne Brouwer
    Centre for Ecology, Evolution and Conservation, School of Biological Sciences, University of East Anglia, Norwich, UK
    Mol Ecol 19:3444-55. 2010
    ..However, such genetic benefits might be hidden and not necessarily apparent in the widely used fitness comparison of extra- and within-pair offspring...
  57. ncbi p53 regulates maternal reproduction through LIF
    Wenwei Hu
    Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903, USA
    Nature 450:721-4. 2007
    ..However, little is known about its normal physiological function. Here we show that p53 is important in reproduction, in a gender-specific manner...
  58. ncbi Neuroendocrinology of reproduction in teleost fish
    Yonathan Zohar
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD, USA
    Gen Comp Endocrinol 165:438-55. 2010
    This review aims at synthesizing the most relevant information regarding the neuroendocrine circuits controlling reproduction, mainly gonadotropin release, in teleost fish...
  59. ncbi Cysteine-rich peptides (CRPs) mediate diverse aspects of cell-cell communication in plant reproduction and development
    Eleanor Marshall
    School of Life Sciences, University of Warwick, Wellesbourne Campus, Wellesbourne, UK
    J Exp Bot 62:1677-86. 2011
    Cell-cell communication in plants is essential for the correct co-ordination of reproduction, growth, and development...
  60. ncbi A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
    M Tatar
    Brown University, Providence, RI 02912, USA, University of Massachusetts, Amherst, MA 01003, USA
    Science 292:107-10. 2001
  61. ncbi Predators and the breeding bird: behavioral and reproductive flexibility under the risk of predation
    Steven L Lima
    Department of Biology, Indiana State University, Terre Haute, Indiana 47809, USA
    Biol Rev Camb Philos Soc 84:485-513. 2009
    ..The topics highlighted herein are all in need more empirical attention, and more experimental field work whenever feasible...
  62. ncbi Hypothalamic thyroid hormone catabolism acts as a gatekeeper for the seasonal control of body weight and reproduction
    Perry Barrett
    Rowett Research Institute, Greenburn Road, Buckburn, Aberdeen AB21 9SB, United Kingdom
    Endocrinology 148:3608-17. 2007
    ..Collectively, these data point to a pivotal role for hypothalamic DIO3 and T(3) catabolism in seasonal cycles of body weight and reproduction in mammals.
  63. ncbi Experimental evidence for density-dependent reproduction in a cooperatively breeding passerine
    Lyanne Brouwer
    Evolutionary Ecology Group, School of Botany and Zoology, Australian National University, Canberra, ACT 0200 Australia
    Ecology 90:729-41. 2009
    ..However, we detected neither density-dependent reproduction nor survival on the basis of natural density variation during this stable period...
  64. ncbi The evolutionary enigma of sex
    Sarah P Otto
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
    Am Nat 174:S1-S14. 2009
    Sexual reproduction entails a number of costs, and yet the majority of eukaryotes engage in sex, at least occasionally. In this article, I review early models to explain the evolution of sex and why they failed to do so...
  65. ncbi Genetic diversity in honey bee colonies enhances productivity and fitness
    Heather R Mattila
    Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA
    Science 317:362-4. 2007
    ..e., drone production and winter survival) of genetically diverse colonies. These results further our understanding of the origins of polyandry in honey bees and its benefits for colony performance...
  66. ncbi The cost of reproduction: the devil in the details
    Lawrence G Harshman
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Trends Ecol Evol 22:80-6. 2007
    The cost of reproduction is of fundamental importance in life-history evolution. However, our understanding of its mechanistic basis has been limited by a lack of detailed functional information at all biological levels...
  67. ncbi A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span
    B Gerisch
    Max Planck Institut fur Molekulare Genetik, Ihnestr 73, D 14195 Berlin, Germany
    Dev Cell 1:841-51. 2001
    ..Sensory neurons, hypodermis, and somatic gonadal cells expressing daf-9 identify potential endocrine tissues. Evidently, lipophilic hormones influence nematode metabolism, diapause, and life span...
  68. ncbi A review of Red Queen models for the persistence of obligate sexual reproduction
    Curtis M Lively
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    J Hered 101:S13-20. 2010
    I present a historical review of coevolutionary models for the evolutionary persistence of sexual reproduction. The focus is on the fate of obligately sexual populations facing competition with one or more obligately asexual clones...
  69. pmc Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development
    Marilyn B Renfree
    The Australian Research Council Centre of Excellence in Kangaroo Genomics, Australia
    Genome Biol 12:R81. 2011
    ..Like other marsupials, it gives birth to highly altricial young, and has a small number of very large chromosomes, making it a valuable model for genomics, reproduction and development.
  70. ncbi Sexually antagonistic genetic variation for fitness in red deer
    Katharina Foerster
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, UK
    Nature 447:1107-10. 2007
  71. ncbi Using a meiosis detection toolkit to investigate ancient asexual "scandals" and the evolution of sex
    Andrew M Schurko
    Department of Biology and Roy J Carver Center for Comparative Genomics, University of Iowa, IA 52242, USA
    Bioessays 30:579-89. 2008
    Sexual reproduction is the dominant reproductive mode in eukaryotes but, in many taxa, it has never been observed. Molecular methods that detect evidence of sex are largely based on the genetic consequences of sexual reproduction...
  72. pmc Mechanistic plasticity of sexual reproduction and meiosis in the Candida pathogenic species complex
    Jennifer L Reedy
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Biol 19:891-9. 2009
  73. pmc Renewable and nonrenewable resources: amino acid turnover and allocation to reproduction in Lepidoptera
    Diane M O'Brien
    Center for Conservation Biology, Department of Biological Sciences, 371 Serra Mall, Stanford University, Stanford, CA 94305 5020, USA
    Proc Natl Acad Sci U S A 99:4413-8. 2002
    The allocation of nutritional resources to reproduction in animals is a complex process of great evolutionary significance...
  74. ncbi Genetic compatibility, mate choice and patterns of parentage: invited review
    T Tregenza
    Ecology and Evolution Group, School of Biology, University of Leeds, UK
    Mol Ecol 9:1013-27. 2000
    ..This may reflect limitations in the potential for the evolution of mate choice for genetic compatibility within populations, although the most promising sources of such incompatibilities have received relatively little research...
  75. ncbi Stress and fish reproduction: the roles of allostasis and hormesis
    Carl B Schreck
    Oregon Cooperative Fish and Wildlife Research Unit, U S Geological Survey, Oregon State University, Corvallis, OR 97331, USA
    Gen Comp Endocrinol 165:549-56. 2010
    This paper is a review of the effects of stress on reproduction in fishes. I hope to further the development of the concepts of allostasis and hormesis as relevant to understanding reproduction in general and in fish in particular...
  76. pmc Reproduction-longevity trade-off in Anopheles gambiae (Diptera: Culicidae)
    Adama Dao
    Malaria Research and Training Center, University of Mali, Bamako, Mali
    J Med Entomol 47:769-77. 2010
    Reduced survival and future reproduction due to of current reproduction is a trade-off known as the cost of reproduction...
  77. ncbi Plant reproductive susceptibility to habitat fragmentation: review and synthesis through a meta-analysis
    Ramiro Aguilar
    Instituto Multidisciplinario de Biología Vegetal, Universidad Nacional de Cordoba CONICET, CC 495, 5000 Cordoba, Argentina
    Ecol Lett 9:968-80. 2006
    ..Animal-mediated pollination is a key process for the sexual reproduction of most extant flowering plants, and the one most consistently studied in the context of habitat fragmentation...
  78. pmc Genetic adaptation to captivity can occur in a single generation
    Mark R Christie
    Department of Zoology, Oregon State University, Corvallis, OR 97331 2914, USA
    Proc Natl Acad Sci U S A 109:238-42. 2012
    ..05 returning offspring in the wild. These results demonstrate that a single generation in captivity can result in a substantial response to selection on traits that are beneficial in captivity but severely maladaptive in the wild...
  79. ncbi Effects of synthetic gestagens on fish reproduction
    Jana Zeilinger
    Bayer Schering Pharma AG, Berlin, Germany
    Environ Toxicol Chem 28:2663-70. 2009
    Although it is well known that estrogenic steroidal hormones are able to affect the sexual development and reproduction of fish at low concentrations, no data on environmental effects of the class of progestogenic hormones are available ..
  80. ncbi Adjustment to climate change is constrained by arrival date in a long-distance migrant bird
    C Both
    Zoological Laboratory, Groningen University, PO Box 14, 9750 AA Haren, The Netherlands
    Nature 411:296-8. 2001
    ..the past 20 years, and many organisms have responded to this increase by advancing the date of their growth and reproduction. Here we show that adaptation to climate change in a long-distance migrant is constrained by the timing of its ..
  81. ncbi Evaluating the life-history trade-off between dispersal capability and reproduction in wing dimorphic insects: a meta-analysis
    Patrick A Guerra
    Department of Biology, McGill University, Montreal, QC, Canada
    Biol Rev Camb Philos Soc 86:813-35. 2011
    A life-history trade-off exists between flight capability and reproduction in many wing dimorphic insects: a long-winged morph is flight-capable at the expense of reproduction, while a short-winged morph cannot fly, is less mobile, but ..
  82. pmc The Mediator complex in plants: structure, phylogeny, and expression profiling of representative genes in a dicot (Arabidopsis) and a monocot (rice) during reproduction and abiotic stress
    Saloni Mathur
    Interdisciplinary Centre for Plant Genomics and Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India
    Plant Physiol 157:1609-27. 2011
    ..Expression profiling of rice (Oryza sativa) and Arabidopsis Med genes reveals that Meds not only act as a basal regulator of gene expression but may also have specific roles in plant development and under abiotic stress conditions...
  83. ncbi Host-plant adaptation drives the parallel evolution of reproductive isolation
    Patrik Nosil
    Department of Biosciences, Behavioural Ecology Research Group, Simon Fraser University, Burnaby BC, Canada, V5A 1S6
    Nature 417:440-3. 2002
    ..Our findings represent a clear demonstration that host-plant adaptation can play a crucial and repeatable role in the early stages of speciation...
  84. ncbi Age, sex, density, winter weather, and population crashes in Soay sheep
    T Coulson
    Institute of Zoology, Zoological Society of London, Regent s Park, London NW1 4RY, UK
    Science 292:1528-31. 2001
    ..In addition, the strength of density-dependent processes is a function of the distribution of weather events. Incorporating demographic heterogeneities into population models can influence dynamics and their response to climate change...
  85. ncbi Longevity and lifetime reproductive success of barn swallow offspring are predicted by their hatching date and phenotypic quality
    Nicola Saino
    Dipartimento di Biologia, Universita di Milano, Via Celoria 26, I 20133 Milano, Italy
    J Anim Ecol 81:1004-12. 2012
    ..In addition, it provides the first evidence from any bird population in the wild that immune response when nestlings predicts individuals' longevity after sexual maturation...
  86. pmc Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice
    Karin S Hougaard
    National Research Centre for the Working Environment, Copenhagen Ø, Denmark
    Part Fibre Toxicol 7:16. 2010
    ..Consequently, also toxicological properties may change compared to the parent compound. We examined developmental and neurobehavioral effects following maternal exposure to a nanoparticulate UV-filter (UV-titan L181)...
  87. ncbi Folate and human reproduction
    Tsunenobu Tamura
    Department of Nutrition Sciences, University of Alabama at Birmingham, AL 35294, USA
    Am J Clin Nutr 83:993-1016. 2006
    ..This review focuses on the relation between various outcomes of human reproduction (ie, pregnancy, lactation, and male reproduction) and folate nutrition and metabolism, homocysteine metabolism, ..
  88. ncbi The Trichoplax genome and the nature of placozoans
    Mansi Srivastava
    Center for Integrative Genomics and Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nature 454:955-60. 2008
  89. ncbi Social bonds of female baboons enhance infant survival
    Joan B Silk
    Department of Anthropology, University of California, Los Angeles UCLA, CA 90095, USA
    Science 302:1231-4. 2003
    ..Our results are consistent with the evidence that social support has beneficial effects on human health and well-being across the life span. For humans and other primates, sociality has adaptive value...
  90. ncbi Male accessory gland secretions: modulators of female reproductive physiology and behavior
    Cedric Gillott
    Department of Biology, University of Saskatchewan, 112 Science Place, Saskatoon, SK S7N 5E2, Canada
    Annu Rev Entomol 48:163-84. 2003
    ..In a few species the secretions include noxious chemicals. These are sequestered by developing eggs that are thereby protected from predators and pathogens when laid...
  91. ncbi Kisspeptins: bridging energy homeostasis and reproduction
    Juan M Castellano
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Spain
    Brain Res 1364:129-38. 2010
    ..The mechanisms for such a close connection between energy balance and reproduction have been the subject of considerable attention; however, our understanding of the neurobiological basis for ..
  92. ncbi Sex determination in Chlamydomonas
    Ursula Goodenough
    Department of Biology, Washington University, St Louis, MO 63130, United States
    Semin Cell Dev Biol 18:350-61. 2007
    ..Reviewed is our current understanding of gametic differentiation and fertilization, initiation of zygote development, and the uniparental inheritance of organelle genomes...
  93. ncbi Sexual reproduction in Aspergillus flavus
    Bruce W Horn
    National Peanut Research Laboratory, Agricultural Research Service, U S Department of Agriculture, Dawson, Georgia 39842, USA
    Mycologia 101:423-9. 2009
    ..Sexual reproduction occurred between sexually compatible strains belonging to different vegetative compatibility groups...
  94. ncbi Assessing the cost of mounting an immune response
    Camille Bonneaud
    Laboratoire de Parasitologie Evolutive, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7103, Universite Pierre et Marie Curie, Paris Cedex 05, France
    Am Nat 161:367-79. 2003
    ..reduction depended on brood size, suggesting that the strength of the trade-off between immune activation and reproduction was affected by the workload required to feed the brood...
  95. ncbi Energy balance and reproduction
    Jill E Schneider
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, USA
    Physiol Behav 81:289-317. 2004
    The physiological mechanisms that control energy balance are reciprocally linked to those that control reproduction, and together, these mechanisms optimize reproductive success under fluctuating metabolic conditions...
  96. ncbi Reproductive isolation and phylogenetic divergence in Neurospora: comparing methods of species recognition in a model eukaryote
    Jeremy R Dettman
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 3102, USA
    Evolution 57:2721-41. 2003
    ..We also observed sympatry-associated sexual dysfunction in interspecific crosses, which was consistent with the existence of reinforcement mechanisms...
  97. pmc Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction
    Min Wu
    Department of Psychiatry, Yale University School of Medicine and the Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, CT 06508, USA
    Proc Natl Acad Sci U S A 106:17217-22. 2009
    A link between energy balance and reproduction is critical for the survival of all species...
  98. pmc Organization and evolutionary trajectory of the mating type (MAT) locus in dermatophyte and dimorphic fungal pathogens
    Wenjun Li
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Eukaryot Cell 9:46-58. 2010
    Sexual reproduction in fungi is governed by a specialized genomic region, the mating type (MAT) locus, whose gene identity, organization, and complexity are diverse...
  99. ncbi The p53 family: guardians of maternal reproduction
    Arnold J Levine
    Institute for Advanced Studies, Princeton, New Jersey 08540, USA
    Nat Rev Mol Cell Biol 12:259-65. 2011
    ..It is now emerging that these proteins also regulate maternal reproduction. Whereas p63 is important for maturation of the egg, p73 ensures normal mitosis in the developing blastocyst...
  100. ncbi Direct ligand-receptor complex interaction controls Brassica self-incompatibility
    S Takayama
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma 630-0101, Japan
    Nature 413:534-8. 2001
  101. ncbi Trans-acting small RNA determines dominance relationships in Brassica self-incompatibility
    Yoshiaki Tarutani
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 0192, Japan
    Nature 466:983-6. 2010
    ..Our finding may provide new insights into the widespread monoallelic gene expression systems...

Research Grants73

  1. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..the luteal phase has implications for preventing early pregnancy loss, and improving the efficiency of assisted reproduction technologies. However, the mechanisms causing functional regression of the primate CL are not known...
  2. Physiology of Hypothalamic Neurosteroidal Progesterone
    Paul E Micevych; Fiscal Year: 2013
    ..One neurosteroid is progesterone, a classic sex hormone involved in the regulation of reproduction. We have previously shown that peripheral estradiol (E2) increases hypothalamic neuroprogesterone (neuroP) ..
    Joann A Boughman; Fiscal Year: 2011
    ..apos;-',. ->^,[unreadable]. ^-.j-'i',-," Authorized for L.ocal Reproduction .Federa"IUse.0n!yw".'i-~i-''i'**-,','[unreadable]...
  4. Biology of IGFs in Bone
    Thomas L Clemens; Fiscal Year: 2013
    ..animalsto enable a wide range of physiological processes including smell, food consumption, metabolism, growth, reproduction and dormancy...
  5. Interdisciplinary Research Training in Reproduction for Indian Fellows
    John C Herr; Fiscal Year: 2010
    ..Emphasis will be placed on training in cell and molecular biology of reproduction with translational components aimed at infertility and the discovery of new leads for contraceptives...
  6. Arcuate nucleus glutamatergic neurons modulate energy homeostasis
    Anthony N van den Pol; Fiscal Year: 2013
    ..a role in other functions that this small but critical part of the brain controls, including regulation of the pituitary and other endocrine organs, reproduction and lactation, growth, metabolism, and response to stress.
  7. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..db/db mice are infertile, LRbS1138 s/s mice are fertile, suggesting that the effects of leptin to regulate reproduction are exerted by JAK/STAT3-independent signaling pathways...
  8. Mechanism of Age-Related Change in Estrogen Receptor Beta Expression in Rat Brain
    ..a crucial role in coordinating the neuroendocrine events that control sexual development, sexual behavior and reproduction. Additionally, estrogen modulates numerous additional facets of brain function...
  9. Analysis of the role of the VRK1 protein kinase in mammalian fertility
    Paula Traktman; Fiscal Year: 2011
    ..suggests that a greater understanding of VRK1 may provide novel insights of significant relevance to human reproduction. A deeper understanding of the signaling pathways that regulate gametogenesis will provide new approaches with ..
  10. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012
    ..Although the available data suggest that modern human reproduction is not susceptible to photoperiodic regulation, brain plasticity and behavioral function very well might be...
  11. Histone Chaperones in Angiogenesis
    Soumen Paul; Fiscal Year: 2012 a key event in many physiological processes, like organ growth and development, wound healing, and reproduction. Angiogenesis is also critical for certain pathological disorders including tumor growth/metastasis and age-..
  12. Transcriptional control of pituitary gonadotropin genes
    Varykina G Thackray; Fiscal Year: 2013
    ..such as apoptosis, stress resistance and metabolism, but their role in the neuroendocrine regulation of reproduction has not been extensively explored...
  13. Vitamin D3 Regulation of the Hypothalamic-Pituitary-Gonadal Axis
    Genevieve S Neal-Perry; Fiscal Year: 2012
    ..the hypothalamic-pituitary-gonadal axis and how vitamin D3 deficiency adversely affects female fertility and reproduction are not understood...
  14. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2012
    ..physiology is the perfect complement for my background in molecular and cellular biology and the physiology of reproduction. During the mentored phase of this award I will learn new experimental skills in muscle mechanics and ..
  15. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2013
    ..physiology is the perfect complement for my background in molecular and cellular biology and the physiology of reproduction. During the mentored phase of this award I will learn new experimental skills in muscle mechanics and ..
  16. Neuropeptide modulation of biogenic amine function and aggression in a crustacean
    Maria A Sosa; Fiscal Year: 2013
    ..fighting behavior can vary depending on circumstances such as availability of food, shelter and partners for reproduction, level of exposure to contaminants, light/dark cycles, health status, etc...
  17. Olfactory Circuits for Reproduction and Reward
    James A Cherry; Fiscal Year: 2013 major histocompatibility alleles, and sex-dependently activate regions of the hypothalamus involved in reproduction. However, failure to identify the neural pathways through which such signals access reproductive circuits has ..
  18. Outcomes of Infertility Treatments in Clinic and Population-Based Cohorts
    Joseph B Stanford; Fiscal Year: 2010
    ..and artificial insemination) to assisted reproductive technologies (ART), which complete early stages of human reproduction in vitro. ART produces high pregnancy rates in the short term, making it an attractive treatment...
  19. Genetics of Cryptococcus sexual reproduction
    Joseph Heitman; Fiscal Year: 2013
    ..We discovered a novel sexual cycle involving only one mating type, termed a-a same-sex mating or unisexual reproduction. Our population genetic studies provide substantial evidence that unisexual reproduction is a predominant route ..
  20. Health Care Disparities in the Pacific Islands Pacific Regional Medical Conferenc
    SAIED SAFABAKHSH; Fiscal Year: 2011
    ..underserved area Review on: Obesity and other health disparities Complicating Filipino Women's Health and Reproduction Update on Congestive Heart Failure The Spectrum of Ischemic Heart Disease Preeclampsia in disadvantaged ..
  21. Environmental regulation of estrogen dependent aggression
    Brian C Trainor; Fiscal Year: 2013
    ..affect a wide variety of processes in the brain and many aspects of behavior including social interactions, reproduction, and memory...
    Lawrence C Layman; Fiscal Year: 2013
    ..occurring human model of impaired GnRH action which provides insight into hypothalamic-pituitary function in reproduction. Kallmann syndrome (KS), a specific subtype of IHH, includes anosmia, as well as other neurologic deficits and ..
  23. Chromosomal Control of Segregation of C. Elegans
    Abby F Dernburg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Sexual reproduction involves the fusion of two sets of chromosomes - one from each parent - to form a new zygote...
    Clinton C MacDonald; Fiscal Year: 2013
    ..Using a variety of techniques, we want to learn the molecular causes of why sperm production fails in males missing the CSTF2T gene, to better understand how to assist these infertile couples. ..
  25. Transposons in Female Reproductive Health and Disease
    Zev Williams; Fiscal Year: 2013
    ..The training program has been designed to ensure command of RNA and transposon biology as applied to female reproduction. Dr...
  26. Functional Analysis of the Embryonic Epigenome in a Non-rodent Model
    Mark E Westhusin; Fiscal Year: 2013 the proposed studies will be useful for generating guidelines and strategies to improve methods for assisted reproduction in humans, prevention of reproductive failure in addition to the prevention of human disease...
  27. Drug Transport at the Blood-Testis Barrier
    Nathan J Cherrington; Fiscal Year: 2013
    ..Although this normal, protective function of the BTB is physiologically beneficial for reproduction, it can also provide a sanctuary for the HIV virus during antiretroviral therapy...
  28. Nuclear Lipids in Steroidogenesis
    Marion B Sewer; Fiscal Year: 2013
    ..hormones are key regulators of a diverse array of physiological processes, including sodium homeostasis, reproduction, and the development of secondary sex characteristics...
    ..PUBLIC HEALTH RELEVANCE: The cell cycle is a fundamental process required for growth, reproduction, and developmental differentiation in all living organisms...
    Nancy M Hollingsworth; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): PROJECT SUMMARY Sexual reproduction requires the creation of haploid gametes from diploid cells...
  31. Sex Differences in the Cannabioid Regulation of Energy Homeostasis
    Edward J Wagner; Fiscal Year: 2013 applicant): Cannabinoids exert a profound impact on the hypothalamic control of biological processes such as reproduction and energy homeostasis...
    Salman Azhar; Fiscal Year: 2013
    ..immunity and blood pressure, whereas gonadal steroids are critical for secondary sex characteristics, reproduction and muscle and bone growth...
  33. Regulation and Function of the Rhox8 homeobox gene in granulosa cells
    JAMES ARTHUR MACLEAN; Fiscal Year: 2010 applicant): Ovulation is a complex and intriguing biological process that is essential for mammalian reproduction. The actions of granulosa cells in the ovary are central to successful ovulation...
  34. The role of the nucleoporin Nup98 in gene regulation
    Martin W Hetzer; Fiscal Year: 2013
    ..precise execution of transcriptional programs during cell differentiation and development relies on faithful reproduction of a specific chromatin state through mitosis...
    Kevin L Grove; Fiscal Year: 2013 balance to gonadotropin-releasing hormone (GnRH) neurons, the central hypothalamic system regulating reproduction, remains elusive...
  36. Monogonont Rotifers as a Model to Investigate the Biology of Aging
    Terry W Snell; Fiscal Year: 2013
    ..genetic background, without the potential inbreeding depression imposed on isogenic lines;3) sexual and asexual reproduction in the same genetic background;4) haploid males, allowing direct expression of alleles and simplifying crosses ..
  37. Obesity and diabetes genetics in Caenorhabditis elegans.
    Alexander A Soukas; Fiscal Year: 2013
    ..elegans rictor indicate that it is a central regulator of metabolism, controlling fat mass, growth, reproduction, and lifespan through regulation of the kinases AKT and SGK4...
  38. PTIP as an epigenetic regulator in male meiosis
    Guo Zhang Zhu; Fiscal Year: 2013
    ..Furthermore, collected information may offer insights into unexplained (or idiopathic) infertility in men and may lead to new strategies for male contraception and assisted reproduction.
  39. The Significance of Leptin Signals to Neonatal Somatotropes and Gonadotropes
    Gwen V Childs; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Adipocyte leptin has been considered as "permissive" for normal reproduction;however, its exact role is uncertain...
  40. Meiosis, SUMOylation and the ZIP3 Protein: Parallel Studies in Mouse and Yeast.
    Neil Hunter; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Chromosome pairing and homologous recombination are required for sexual reproduction and chromosome repair...
  41. Molecular Analysis of Juvenile Hormone Action
    Subba R Palli; Fiscal Year: 2013
    ..20-hydroxyecdysone, 20E is the most active form) are the major hormones that regulate development and reproduction in insects...
  42. The evolutionary and molecular mechanisms underlying sperm performance in an emer
    Heidi S Fisher; Fiscal Year: 2013
    ..provided important insights into the molecular, developmental and physiological processes underlying mammalian reproduction and have served as models for studies of human infertility...
  43. Genetic control of quantitative traits associated with the metabolic syndrome
    Maria De Luca; Fiscal Year: 2013 that while individuals with efficient mitochondrial coupling can successfully use their fat storage for reproduction and for coping with environmental challenges, such as fighting infection, those with less coupling efficiency ..
  44. Lipid metabolism during tsetse reproduction
    JOSH B BENOIT; Fiscal Year: 2013 develop the candidate's ability to assess the biochemistry, molecular biology and physiology of vector reproduction. The training plan provides opportunities to conduct extensive studies at the interface between molecular ..
  45. Mechanisms for the evolution of novel DNA specificity in a transcription factor f
    Joseph W Thornton; Fiscal Year: 2013
    ..SRs play key roles in development, reproduction, homeostasis, cancer, and many diseases...
  46. Contribution of Sperm Nucleus to Paternal DNA Replication
    WILLIAM S WARD; Fiscal Year: 2013
    ..of molecular inheritance beyond the genetic code, and this knowledge has a direct bearing on human assisted reproduction practices...
    DAVID IRWIN GREENSTEIN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Abstract Sexual reproduction of multicellular organisms depends critically on communication between cells of the somatic gonad and the germ line, and ultimately between sperm and egg...
  48. Tsetse Fecundity Reduction for Trypanosomiasis Control
    Serap Aksoy; Fiscal Year: 2013
    ..b>Reproduction in tsetse is also unique in that it requires the presence of obligate mutualist symbiotic bacteria...
  49. Molecular probes for a vOTU from CCHFV using a fluorogenic peptide
    SCOTT DUSAN PEGAN; Fiscal Year: 2013 perform similar roles in the economically devastating ssRNA (+) Arteriviruses, Porcine Respiratory and Reproduction Syndrome and Equine Arteritis viruses...
  50. The Kiss1 system in the neuroendocrine control of reproduction
    VICTOR MANUEL NAVARRO; Fiscal Year: 2013
    ..the physiological function of subpopulations of Kiss1 neurons that regulate the secretion of GnRH and hence reproduction. Kiss1 expressing neurons are found in two discrete nuclei in the hypothalamus, the ARC and anteroventral ..
  51. The Role of TAF4b in Spermatogonial Stem Cell Maintenance and Self-Renewal
    Eric Gustafson; Fiscal Year: 2013
    ..the general transcription factors TFIIA and TFIID execute highly critical and selective functions in regulating reproduction and fertility...
  52. Role of nuclear receptors in origin and differentiation of spermatozoa
    ADAM MICHAEL REITZEL; Fiscal Year: 2011
    ..a fundamental role in human fertility is a critical step towards advancing diagnosis and treatment in human reproduction. Utilizing morphologically simple and experimentally tractable animal models to test specific molecular ..
  53. Origins of Diversity at Human Classical MHC Class I Genes
    PETER R PARHAM; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human NK cell functions in immunity and reproduction are controlled by highly polymorphic interactions between killer cell immunoglobulin-like receptors (KIR) and major histocompatibility complex (MHC)..
  54. The Transport of Nutritional Heme in Animal Development
    Iqbal Hamza; Fiscal Year: 2013
    ..Worms require dietary heme for growth and reproduction. Thus, the worm model provides a clean genetic background devoid of endogenous heme and the ability to ..
  55. Role of mineralocorticoid receptor in primate ovarian function
    CHARLES CHAFFIN; Fiscal Year: 2009
    ..Aging and reproduction is clearly a growing topic in the United States, and a better knowledge of basic ovarian processes will ..
  56. Role of LHX3 Protein Isoforms in Pituitary Development
    SIMON JAMES RHODES; Fiscal Year: 2012
    ..polypeptide hormones that are critical for many aspects of human development and physiology, including growth, reproduction, the stress response, metabolic homeostasis, and lactation...
  57. Monitoring Social Change: Health, Reproduction, Aging
    Barry M Popkin; Fiscal Year: 2012
  58. Embryonic regulation of GnRH neuron migration and function
    David J Kozlowski; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Central nervous system (CNS) control of reproduction is mediated by a population of neuroendocrine cells that secrete gonadotropin-releasing hormone (GnRH)...
  59. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    PHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010
    ..this area has been impeded by the relative rarity of some pathologies and because functional assessment of male reproduction is feasible only at adult age, i.e., many years after the initial toxic exposures...
  60. Epigenetic control of sex chromosome behavior in meiosis.
    JoAnne Engebrecht; Fiscal Year: 2013
    ..provided by applicant): Meiosis is a special type of cell division that produces haploid gametes for sexual reproduction. During meiosis, chromosome pairing, synapsis and crossing over rely on homology between the paternal and ..
  61. Genetics of Meiosis and Recombination in Mice
    John C Schimenti; Fiscal Year: 2013
    ..This is important for assessing the safety of checkpoint inhibition for reasons of assisted reproduction or fertility preservation in cancer patients;and 4) Determine if CHK2 drug inhibitors can protect oocytes from ..
  62. Mechanisms of Inflammatory Lung Disease in Neonates
    BARRY I WEINBERGER; Fiscal Year: 2010
    ..The American Academy of Pediatrics, U.S. FDA, and the Center for the Evaluation of Risks to Human Reproduction have all recently noted that there is an urgent public health need for more data on the toxicity of phthalates ..
  63. New Mouse Mutation Exhibiting Failed Fertilization
    Mary Ann Handel; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Worldwide, couples want to manage their own reproduction and there is great need for more diverse contraceptives, especially ones targeted to aspects of male reproduction...
  64. Molecular Mechanisms of Endocrine Disruption in Bass
    Nancy D Denslow; Fiscal Year: 2011
    ..Poor reproduction and altered plasma hormone levels have been observed in largemouth bass living in ecosystems polluted with ..
    Margaret E Wierman; Fiscal Year: 2010
    ..nIHH) harbor mutations in Axl, supporting the importance of understanding the role of the TAM system in reproduction. In this application: Aim 1 will determine the ligand dependence of the TAM family effects on reproduction and ..
  66. Comparative and functional proteomics of germline chromatin in C. elegans
    KENNETH HILLERS; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Sexual reproduction in diploid eukaryotes involves formation of haploid gametes through a specialized cell division known as meiosis...
    REGINA TURNER; Fiscal Year: 2001
    ..Dr. Moss' lab is part of the Center for Research on Reproduction and Women s Health ...
  68. Minimum Y gene complement necessary for successful ART
    MONIKA WARD; Fiscal Year: 2009
    ..this application is to determine the minimum Y chromosome gene requirement that is compatible with successful reproduction by assisted reproductive technologies (ART)...
    Mary Haasch; Fiscal Year: 2001
    ..with signaling cross-talk between metabolic pathways and nuclear hormone receptors producing perturbations in reproduction and development...
  70. Nutritional Ecology of Adult Anopheles gambiae
    WOODBRIDGE FOSTER; Fiscal Year: 2006
    ..New evidence indicates that plants and mammals may be equally important to population growth, reproduction, and survival of An. gambiae...
    Robert Steiner; Fiscal Year: 2005
    ..nucleus and median eminence of the hypothalamus, which are nodal points for integration of metabolism and reproduction. Work from our laboratory and others has shown that GALP neurons are regulated by the metabolic hormones leptin ..
    Edward Clark; Fiscal Year: 2009
    ..issue, despite increasing public concern about the effect of chemicals and environmental contaminants on human reproduction and, thereby, serves as the impetus for study...
    Darrell Brann; Fiscal Year: 2005
    DESCRIPTION (Scanned from the applicant's description): Estrogen is well known to play a critical role in reproduction and to have important beneficial effects on the brain...