heat shock response

Summary

Summary: A constellation of responses that occur when an organism is exposed to excessive heat and other environmental stresses. Responses include synthesis of some proteins, repression of other proteins, and expression of new proteins. (From Segen, Dictionary of Modern Medicine, 1992)

Top Publications

  1. ncbi The heat shock response: life on the verge of death
    Klaus Richter
    Munich Center for Integrated Protein Science, Department Chemie Technische Universität München, 85747 Garching, Germany
    Mol Cell 40:253-66. 2010
  2. ncbi Variation in the heat shock response and its implication for predicting the effect of global climate change on species' biogeographical distribution ranges and metabolic costs
    L Tomanek
    Center for Coastal Marine Sciences and Environmental Proteomics Laboratory, Department of Biological Sciences, California Polytechnic State University, San Luis Obispo, CA 93407, USA
    J Exp Biol 213:971-9. 2010
  3. ncbi Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology
    M E Feder
    Department of Organismal Biology and Anatomy and Committee on Evolutionary Biology, University of Chicago, Illinois 60637, USA
    Annu Rev Physiol 61:243-82. 1999
  4. pmc Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons
    Veena Prahlad
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    Science 320:811-4. 2008
  5. pmc Heat shock response relieves ER stress
    Yu Liu
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48104, USA
    EMBO J 27:1049-59. 2008
  6. pmc Convergence of molecular, modeling, and systems approaches for an understanding of the Escherichia coli heat shock response
    Eric Guisbert
    Department of Biochemistry, University of California at San Francisco, San Francisco, CA 94158 2517, USA
    Microbiol Mol Biol Rev 72:545-54. 2008
  7. ncbi The heat shock response and chaperones/heat shock proteins in brain tumors: surface expression, release, and possible immune consequences
    Michael W Graner
    The Preston Robert Tisch Brain Tumor Center, Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 27:11214-27. 2007
  8. pmc Regulation of Corynebacterium glutamicum heat shock response by the extracytoplasmic-function sigma factor SigH and transcriptional regulators HspR and HrcA
    Shigeki Ehira
    Research Institute of Innovative Technology for the Earth, 9 2 Kizugawadai, Kizugawa, Kyoto 619 0292, Japan
    J Bacteriol 191:2964-72. 2009
  9. ncbi Heat shock response inhibits NF-kappaB activation and cytokine production in murine Kupffer cells
    Dongxu Sun
    Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, PR China
    J Surg Res 129:114-21. 2005
  10. ncbi Heat shock response modulators as therapeutic tools for diseases of protein conformation
    Sandy D Westerheide
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 280:33097-100. 2005

Research Grants

Detail Information

Publications329 found, 100 shown here

  1. ncbi The heat shock response: life on the verge of death
    Klaus Richter
    Munich Center for Integrated Protein Science, Department Chemie Technische Universität München, 85747 Garching, Germany
    Mol Cell 40:253-66. 2010
    ..In this Review, we summarize the concepts of the protective Hsp network...
  2. ncbi Variation in the heat shock response and its implication for predicting the effect of global climate change on species' biogeographical distribution ranges and metabolic costs
    L Tomanek
    Center for Coastal Marine Sciences and Environmental Proteomics Laboratory, Department of Biological Sciences, California Polytechnic State University, San Luis Obispo, CA 93407, USA
    J Exp Biol 213:971-9. 2010
    The preferential synthesis of heat shock proteins (Hsps) in response to thermal stress [the heat shock response (HSR)] has been shown to vary in species that occupy different thermal environments...
  3. ncbi Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology
    M E Feder
    Department of Organismal Biology and Anatomy and Committee on Evolutionary Biology, University of Chicago, Illinois 60637, USA
    Annu Rev Physiol 61:243-82. 1999
    ....
  4. pmc Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons
    Veena Prahlad
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    Science 320:811-4. 2008
    ..In response to a rapid increase in temperature, all cells undergo a heat shock response, an ancient and highly conserved program of stress-inducible gene expression, to reestablish cellular ..
  5. pmc Heat shock response relieves ER stress
    Yu Liu
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48104, USA
    EMBO J 27:1049-59. 2008
    ..We tested whether heat shock response (HSR) can relieve ER stress...
  6. pmc Convergence of molecular, modeling, and systems approaches for an understanding of the Escherichia coli heat shock response
    Eric Guisbert
    Department of Biochemistry, University of California at San Francisco, San Francisco, CA 94158 2517, USA
    Microbiol Mol Biol Rev 72:545-54. 2008
    The heat shock response (HSR) is a homeostatic response that maintains the proper protein-folding environment in the cell. This response is universal, and many of its components are well conserved from bacteria to humans...
  7. ncbi The heat shock response and chaperones/heat shock proteins in brain tumors: surface expression, release, and possible immune consequences
    Michael W Graner
    The Preston Robert Tisch Brain Tumor Center, Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 27:11214-27. 2007
    The heat shock response is a highly conserved "stress response" mechanism used by cells to protect themselves from potentially damaging insults...
  8. pmc Regulation of Corynebacterium glutamicum heat shock response by the extracytoplasmic-function sigma factor SigH and transcriptional regulators HspR and HrcA
    Shigeki Ehira
    Research Institute of Innovative Technology for the Earth, 9 2 Kizugawadai, Kizugawa, Kyoto 619 0292, Japan
    J Bacteriol 191:2964-72. 2009
    b>Heat shock response in Corynebacterium glutamicum was characterized by whole-genome expression analysis using a DNA microarray. It was indicated that heat shock response of C...
  9. ncbi Heat shock response inhibits NF-kappaB activation and cytokine production in murine Kupffer cells
    Dongxu Sun
    Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, PR China
    J Surg Res 129:114-21. 2005
    ..The anti-inflammatory effects of heat shock response (HSP) have been well documented...
  10. ncbi Heat shock response modulators as therapeutic tools for diseases of protein conformation
    Sandy D Westerheide
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 280:33097-100. 2005
    ..factor 1 (HSF1), the master stress-inducible regulator, and our current understanding of pharmacologically active small molecule regulators of the heat shock response as a therapeutic strategy for protein conformational diseases.
  11. ncbi Stress-controlled transcription factors, stress-induced genes and stress tolerance in budding yeast
    F Estruch
    Departamento de Bioquimica y Biologia Molecular, Universitat de Valencia, Burjassot, Spain
    FEMS Microbiol Rev 24:469-86. 2000
    ..In this review the progress made in recent years is discussed...
  12. ncbi Activation of the heat shock response in plants by chlorophenols: transgenic Physcomitrella patens as a sensitive biosensor for organic pollutants
    Younousse Saidi
    Department of Plant Molecular Biology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
    Plant Cell Environ 30:753-63. 2007
    ..It is also a powerful tool to study the role of heat shock proteins (HSPs) in plants exposed to combined chemical and environmental stresses...
  13. ncbi Molecular aspects of arsenic stress
    L Bernstam
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor 48109 2029, USA
    J Toxicol Environ Health B Crit Rev 3:293-322. 2000
    ..Arsenite-induced stress at the molecular level shares many features with the heat shock response. This includes the differential sensitivity of the stress signal pathway elements to the magnitude of the ..
  14. pmc Pharmacological induction of the heat shock response improves myelination in a neuropathic model
    Sunitha Rangaraju
    Department of Neuroscience, College of Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0244, USA
    Neurobiol Dis 32:105-15. 2008
    ..These results warrant further studies with HSP90 inhibitors as potential therapeutic candidates for hereditary demyelinating neuropathies...
  15. pmc Heat shock protein 90 homeostasis controls stage differentiation in Leishmania donovani
    M Wiesgigl
    Bernhard Nocht Institute for Tropical Medicine, D-20359 Hamburg, Germany
    Mol Biol Cell 12:3307-16. 2001
    ..Moreover, we demonstrate that Hsp90 serves as a feedback inhibitor of the cellular heat shock response in Leishmania...
  16. ncbi Overexpression of HSP70 is induced by ionizing radiation in C3H 10T1/2 cells and protects from DNA damage
    V Calini
    Dipartimento di Scienze dell Ambiente e del Territorio, Universita Milano Bicocca, p zza della Scienza 1, 20126 Milan, Italy
    Toxicol In Vitro 17:561-6. 2003
    ..A preliminary investigation on the cell cycle does not evidence a significant protective action of inducible Hsp70 on it...
  17. pmc Production of reactive oxygen species, alteration of cytosolic ascorbate peroxidase, and impairment of mitochondrial metabolism are early events in heat shock-induced programmed cell death in tobacco Bright-Yellow 2 cells
    Rosa Anna Vacca
    Istituto di Biomembrane e Bioenergetica, Consiglio Nazionale delle Ricerche, Via Amendola 165 A, I 70126 Bari, Italy
    Plant Physiol 134:1100-12. 2004
    ..Thus, we propose that in the early phase of tobacco Bright-Yellow 2 cell PCD, ROS production occurs, perhaps because of damage of the cell antioxidant system, with impairment of the mitochondrial oxidative phosphorylation...
  18. pmc Global analysis of heat shock response in Desulfovibrio vulgaris Hildenborough
    S R Chhabra
    Biosystems Research Department, Mailstop 9292, Sandia National Laboratory, 7011 East Ave, Livermore, CA 94550, USA
    J Bacteriol 188:1817-28. 2006
    ..The proteomics study also suggested the possibility of posttranslational modifications in the chaperones DnaK, AhpC, GroES (DVU1977), and GroEL (DVU1976) and also several periplasmic ABC transporters...
  19. pmc Setting the tempo in development: an investigation of the zebrafish somite clock mechanism
    Francois Giudicelli
    Vertebrate Development Laboratory, Cancer Research UK London Research Institute, London, United Kingdom
    PLoS Biol 5:e150. 2007
    ....
  20. ncbi Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    Ao Lin Hsu
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2200, USA
    Science 300:1142-5. 2003
    ..The small heat-shock proteins also delay the onset of polyglutamine-expansion protein aggregation, suggesting that these proteins couple the normal aging process to this type of age-related disease...
  21. ncbi Differential gene expression during thermal stress and bleaching in the Caribbean coral Montastraea faveolata
    M K DeSalvo
    School of Natural Sciences, University of California, Merced, PO Box 2039, Merced, CA 95344, USA
    Mol Ecol 17:3952-71. 2008
    ....
  22. ncbi Genetic dissection of the roles of chaperones and proteases in protein folding and degradation in the Escherichia coli cytosol
    T Tomoyasu
    Institut fur Biochemie und Molekularbiologie, Universitat Freiburg, Hermann Herder Str 7, D 79104 Freiburg, Germany
    Mol Microbiol 40:397-413. 2001
    ..At 42 degrees C, ClpXP and Lon became essential for viability of cells with low DnaK levels, indicating synergistic action of proteases and the DnaK system, which is essential for cell growth at 42 degrees C...
  23. pmc sigmaB modulates virulence determinant expression and stress resistance: characterization of a functional rsbU strain derived from Staphylococcus aureus 8325-4
    Malcolm J Horsburgh
    Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, England S10 2TN
    J Bacteriol 184:5457-67. 2002
    ..We suggest that SarA is not likely to be the effector in the overall sigmaB-mediated effect on agr expression...
  24. ncbi Cytosolic HSP90 regulates the heat shock response that is responsible for heat acclimation in Arabidopsis thaliana
    Kenji Yamada
    Department of Cell Biology, National Institute for Basic Biology, Aichi, Japan
    J Biol Chem 282:37794-804. 2007
    ..Most of these genes have heat shock response element-like motifs in their promoters, which suggests that heat shock transcription factor (HSF) is ..
  25. ncbi Roles of the heat shock transcription factors in regulation of the heat shock response and beyond
    L Pirkkala
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Finland
    FASEB J 15:1118-31. 2001
    The heat shock response, characterized by increased expression of heat shock proteins (Hsps) is induced by exposure of cells and tissues to extreme conditions that cause acute or chronic stress...
  26. pmc Heat shock response and acute lung injury
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Kindervelt Laboratory for Critical Care Medicine Research, Childrens Hospital Research Foundation, Cincinnati, OH 45229, USA
    Free Radic Biol Med 42:1-14. 2007
    ..e., exposure to heat stress leading to resistance to oxidant stress). The heat shock response is one of the more commonly described examples of stress adaptation and is characterized by the rapid ..
  27. ncbi Induction of heat shock response protects the heart against atrial fibrillation
    Bianca J J M Brundel
    Department of Medicine and Research Center, Montreal Heart Institute, 5000 Belanger St E, Montreal, Quebec H1T 1C8, Canada
    Circ Res 99:1394-402. 2006
    ..These findings advance our understanding of the biochemical determinants of AF and suggest the possibility that HSP induction may be an interesting novel approach to preventing clinical AF...
  28. pmc Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods
    Debraj GuhaThakurta
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63114, USA
    Genome Res 12:701-12. 2002
    ..The contributions of individual sites toward induction of transcription on HS are nonadditive, which indicates interaction and cross-talk between the sites, possibly through the transcription factors (TFs) binding to these sites...
  29. pmc A Caenorhabditis elegans MAP kinase kinase, MEK-1, is involved in stress responses
    M Koga
    Department of Biology, Faculty of Sciences, Kyushu University Graduate School, Fukuoka 812 8581, Japan
    EMBO J 19:5148-56. 2000
    ..Expression of an activated form of MEK-1 in the whole animal or specifically in the pharynx inhibited pharyngeal pumping. These results suggest a role for mek-1 in stress responses, with a focus in the pharynx and/or intestine...
  30. ncbi Levels of DnaK and DnaJ provide tight control of heat shock gene expression and protein repair in Escherichia coli
    T Tomoyasu
    Institut fur Biochemie und Molekularbiologie, Universitat Freiburg, Hermann Herder Str 7, D 79104 Freiburg, Germany
    Mol Microbiol 30:567-81. 1998
    ..resulted in decreased level and activity of sigma32 at intermediate temperature and faster shut-off of the heat shock response. Small decreases in their levels caused inverse effects and, furthermore, reduced the refolding efficiency ..
  31. pmc Dose response relationship in anti-stress gene regulatory networks
    Qiang Zhang
    Division of Computational Biology, CIIT Centers for Health Research, Research Triangle Park, North Carolina, United States of America
    PLoS Comput Biol 3:e24. 2007
    ..This work would help biologists and especially toxicologists to better assess and predict the cellular impact brought about by biological stressors...
  32. ncbi Consequences of reductive evolution for gene expression in an obligate endosymbiont
    Jennifer L Wilcox
    Department of Ecology and Evolutionary Biology, University of Arizona, BioSciences West Rm 310, Tucson 85721, USA
    Mol Microbiol 48:1491-500. 2003
    ..aphidicola. Our demonstration of a diminished stress response validates reports of temperature sensitivity in B. aphidicola and suggests that this reduced bacterial genome exhibits transcriptional inflexibility...
  33. pmc Hyperfluidization-coupled membrane microdomain reorganization is linked to activation of the heat shock response in a murine melanoma cell line
    Eniko Nagy
    Institute of Biochemistry, Biological Research Center, Hungarian Academy of Sciences, P O Box 521, H 6701, Szeged, Hungary
    Proc Natl Acad Sci U S A 104:7945-50. 2007
    ....
  34. pmc Human sat III and Drosophila hsr omega transcripts: a common paradigm for regulation of nuclear RNA processing in stressed cells
    Caroline Jolly
    INSERM U309, La Tronche, F 38700, France
    Nucleic Acids Res 34:5508-14. 2006
    Exposure of cells to stressful conditions elicits a highly conserved defense mechanism termed the heat shock response, resulting in the production of specialized proteins which protect the cells against the deleterious effects of stress...
  35. ncbi The transcriptional co-activator MBF1c is a key regulator of thermotolerance in Arabidopsis thaliana
    Nobuhiro Suzuki
    Department of Biochemistry and Molecular Biology, University of Nevada, Reno, NV 89557, USA
    J Biol Chem 283:9269-75. 2008
    ..Our results provide evidence for the existence of a tightly coordinated heat stress-response network, involving trehalose-, SA-, and ethylene-signaling pathways, that is under the control of MBF1c...
  36. ncbi The diversity of plant heat stress transcription factors
    Pascal von Koskull-Döring
    Department of Molecular Cell Biology, J W Goethe University, Biocenter, Max von Laue Str 9, D 60438 Frankfurt am Main, Germany
    Trends Plant Sci 12:452-7. 2007
    ..The output from these analyses provides increasing evidence that individual Hsfs have unique functions as part of different signal transduction pathways operating in response to environmental stress and during development...
  37. ncbi Neural differentiation and the attenuated heat shock response
    Jingxian Yang
    Department of Cell Biology and Neuroscience, Rutgers State University of New Jersey, Piscataway, New Jersey, USA
    Brain Res 1203:39-50. 2008
    ..Analysis of biochemical events involved in induction of the heat shock response (HSR) reveal a blunted activation of HSF1 DNA-binding activity, and decreased induction of the mRNA(hsp70) ..
  38. pmc Molecular and genetic evidence for the key role of AtCaM3 in heat-shock signal transduction in Arabidopsis
    Wei Zhang
    Institute of Molecular Cell Biology, Hebei Normal University, Shijiazhuang 050016, China
    Plant Physiol 149:1773-84. 2009
    ..Taken together, these results suggest that endogenous AtCaM3 is a key component in the Ca2+-CaM HS signal transduction pathway...
  39. ncbi Heterologous microarray experiments used to identify the early gene response to heat stress in a coral reef fish
    Karin S Kassahn
    School of Tropical Biology, James Cook University, Townsville, Qld 4811, Australia
    Mol Ecol 16:1749-63. 2007
    ....
  40. pmc Global transcriptional response of Bacillus subtilis to heat shock
    J D Helmann
    Department of Microbiology, Cornell University, Ithaca, New York 14853 8101, USA
    J Bacteriol 183:7318-28. 2001
    ..Since many different conditions elicit both specific and general stress responses, knowledge of the heat-induced general stress response reported here will be helpful for interpreting future microarray studies of other stress responses...
  41. ncbi Mechanism and function of heat shock-dependent IkappaBalpha expression
    K E Dunsmore
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Inflamm Res 55:254-9. 2006
    ..Herein we sought to elucidate the mechanisms by which heat shock induces Ikappa Balpha gene expression and the functional consequences of heat shock-mediated Ikappa Balpha gene expression in A549 cells...
  42. ncbi pH shock induces overexpression of regulatory and biosynthetic genes for actinorhodin productionin Streptomyces coelicolor A3(2)
    Yoon Jung Kim
    Department of Chemical and Biomolecular Engineering The Brain Korea 21 Program, Korea Advanced Institute of Science and Technology, 373 1, Guseong Dong, Yuseong Gu, Daejeon, 305 701, South Korea
    Appl Microbiol Biotechnol 76:1119-30. 2007
    ..It is deduced that these metabolic changes caused by pH shock have positively contributed to the stimulation of actinorhodin biosynthesis in a concerted manner...
  43. pmc Chlorella saccharophila cytochrome f and its involvement in the heat shock response
    Anna Zuppini
    Dipartimento di Biologia, Universita di Padova, Via U Bassi 58 B, 35131 Padova, Italy
    J Exp Bot 60:4189-200. 2009
    ....
  44. ncbi Melanoma-associated antigen tyrosinase but not Melan-A/MART-1 expression and presentation dissociate during the heat shock response
    Valeria Milani
    Clinical Cooperation Group of Hyperthermia, Internal Medicine Department III, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Int Immunol 17:257-68. 2005
    ..The heat shock response was induced by treating the cells with two different thermal isoeffect doses, which resulted in equivalent ..
  45. ncbi Heat shock genes and the heat shock response in zebrafish embryos
    P H Krone
    Department of Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, Canada
    Biochem Cell Biol 75:487-97. 1997
    ..The data raise a number of interesting questions regarding the function and regulation of these heat shock genes in zebrafish embryos during normal development and following exposure to environmental stress...
  46. pmc Fever and the heat shock response: distinct, partially overlapping processes
    J D Hasday
    Department of Medicine, University of Maryland School of Medicine and the Medicine and Research Services of the Baltimore VA Medical Center, 21201, USA
    Cell Stress Chaperones 5:471-80. 2000
    The heat shock response is an ancient and highly conserved process that is essential for surviving environmental stresses, including extremes of temperature...
  47. pmc Sequestration of TRAF2 into stress granules interrupts tumor necrosis factor signaling under stress conditions
    Woo Jae Kim
    National Research Laboratory, Postech Biotech Center, Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Hyoja Dong San 31, Pohang, Kyungbuk 790 784, Korea
    Mol Cell Biol 25:2450-62. 2005
    ..This suggests that stressed cells lower their biological activities by sequestration of translation factors and TRAF2 into SGs through a protein-protein interaction...
  48. pmc Transcription profiling of the stringent response in Escherichia coli
    Tim Durfee
    Department of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Bacteriol 190:1084-96. 2008
    ..However, one-half of the up-regulated genes have unknown functions. How these results are correlated with the various effects of (p)ppGpp (in particular, RNA polymerase redistribution) is discussed...
  49. ncbi Alzheimer's Abeta fused to green fluorescent protein induces growth stress and a heat shock response
    Jo Caine
    CSIRO P Health Flagship and CSIRO Molecular and Health Technologies, Parkville, Vic, Australia
    FEMS Yeast Res 7:1230-6. 2007
    ..Cells producing Abeta exhibited a lower growth yield and a heat shock response, showing that Abeta fusions promote stress in cells and supporting the notion that intracellular Abeta is a ..
  50. pmc Analysis of the heat shock response in mouse liver reveals transcriptional dependence on the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha)
    Beena Vallanat
    NHEERL Toxicogenomics Core, US EPA, Research Triangle Park, NC 27711, USA
    BMC Genomics 11:16. 2010
    ..Many of these genes are also transcriptionally regulated by heat shock (HS) through activation by HS factor-1 (HSF1). We hypothesized that there are interactions on a genetic level between PPARalpha and the HS response mediated by HSF1...
  51. pmc Analysis of the heat shock response of Neisseria meningitidis with cDNA- and oligonucleotide-based DNA microarrays
    Matthias Guckenberger
    Institute for Hygiene and Microbiology, University of Wurzburg, Germany
    J Bacteriol 184:2546-51. 2002
    ..comprising a subset of Neisseria meningitidis genes were assessed for study of the meningococcal heat shock response and found to be highly suitable for transcriptional profiling of N. meningitidis...
  52. ncbi alpha-lipoic acid inhibits endotoxin-stimulated expression of iNOS and nitric oxide independent of the heat shock response in RAW 264.7 cells
    Vincent G Demarco
    Department of Child Health, University of Missouri, Columbia, MO 65211, USA
    Free Radic Res 38:675-82. 2004
    The heat shock response protects against sepsis-induced mortality, organ injury, cardiovascular dysfunction, and apoptosis...
  53. ncbi Integrating the stress response: lessons for neurodegenerative diseases from C. elegans
    Veena Prahlad
    Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    Trends Cell Biol 19:52-61. 2009
    ....
  54. pmc P-Glycoprotein-mediated resistance to Hsp90-directed therapy is eclipsed by the heat shock response
    Andrea K McCollum
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer Res 68:7419-27. 2008
    ..Taken together, our results indicate that targeting of Hsp27 and Hsp70 should be exploited to increase the clinical efficacy of Hsp90-directed therapy...
  55. pmc Hsp40 couples with the CSPalpha chaperone complex upon induction of the heat shock response
    Sarah J Gibbs
    Department of Physiology and Biophysics and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    PLoS ONE 4:e4595. 2009
    ..In view of the crucial importance of stress-induced chaperones in the protection against cell death, our data attribute a role for Hsp40 crosstalk with CSPalpha in neuroprotection...
  56. ncbi Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock
    J M Park
    National Creative Research Initiative Center for Genome Regulation, Department of Biochemistry, Yonsei University, 120 749, Seoul, South Korea
    Mol Cell 8:9-19. 2001
    ..Therefore, the activator-Mediator interaction likely underlies the initiation of signal transfer from enhancer-bound activators to the basal transcription machinery...
  57. ncbi An important role of the heat shock response in infected cells for replication of baculoviruses
    Yulia V Lyupina
    N K Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 26 Vavilova Str, Moscow 119991, Russia
    Virology 406:336-41. 2010
    ..HSPs, decreased the rate of viral DNA synthesis in infected cells more than one order of magnitude and markedly suppressed the release of budded viruses indicating the importance of the heat shock response for baculovirus replication.
  58. ncbi Increasing Saccharomyces cerevisiae stress resistance, through the overactivation of the heat shock response resulting from defects in the Hsp90 chaperone, does not extend replicative life span but can be associated with slower chronological ageing of non
    N Harris
    Department of Biochemistry and Molecular Biology, University College London, UK
    Mol Genet Genomics 265:258-63. 2001
    ..Overactivation of the heat shock response caused no slowing of replicative senescence...
  59. pmc Genome-wide analysis of the biology of stress responses through heat shock transcription factor
    Ji Sook Hahn
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109 0606, USA
    Mol Cell Biol 24:5249-56. 2004
    ..This genome-wide identification of HSF target genes provides novel insights into the role of HSF in growth, development, disease, and aging and in the complex metabolic reprogramming that occurs in all cells in response to stress...
  60. ncbi Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70
    Tero Pekka Alastalo
    Turku Centre for Biotechnology, University of Turku, Abo Akademi University, BioCity, PO Box 123, FIN 20521 Turku, Finland
    J Cell Sci 116:3557-70. 2003
    ..We propose that the regulated subcellular distribution of Hsp70 is an important regulatory mechanism of HSF1-mediated heat shock response.
  61. ncbi Modulation of human heat shock factor trimerization by the linker domain
    P C Liu
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109 0606, USA
    J Biol Chem 274:17219-25. 1999
    ....
  62. ncbi The protective role of HSP90 against 3-hydroxykynurenine-induced neuronal apoptosis
    M W Lee
    Department of Anatomy, College of Medicine, Chung-Ang University, Seoul, Korea
    Biochem Biophys Res Commun 284:261-7. 2001
    ..These results suggest that 3HK induces apoptosis in neuroblastoma SK-N-SN cells and that HSP90 is major contributing protein component of protection against 3HK induced apoptosis...
  63. pmc Stress-induced nuclear bodies are sites of accumulation of pre-mRNA processing factors
    M Denegri
    Istituto di Genetica Biochimica ed Evoluzionistica del Consiglio Nazionale delle Richerche, Pavia 27100, Italy
    Mol Biol Cell 12:3502-14. 2001
    ..Accordingly, the formation of stress-induced SNBs is accompanied by a change in the splicing pattern of the adenovirus E1A transcripts...
  64. ncbi Global transcriptome analysis of the heat shock response of Bifidobacterium longum
    Enea Rezzonico
    Nestle Research Center, Vers chez les Blanc, Lausanne, Switzerland
    FEMS Microbiol Lett 271:136-45. 2007
    ..longum cells to heat shock was suggested by the induction of the gene encoding the tmRNA-associated small protein B (SmpB) with concomitant high constitutive expression of the tmRNA gene...
  65. pmc Transcriptional analysis of the groES-groEL1, groEL2, and dnaK genes in Corynebacterium glutamicum: characterization of heat shock-induced promoters
    Carlos Barreiro
    Institute of Biotechnology of León INBIOTEC Science Park of León Av Real, 1, Leon, 24006, Spain
    J Bacteriol 186:4813-7. 2004
    ....
  66. pmc The shock of aging: molecular chaperones and the heat shock response in longevity and aging--a mini-review
    Stuart K Calderwood
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Gerontology 55:550-8. 2009
    ..However, the precise mechanisms that determine the rates of aging in organisms are not known...
  67. ncbi Chaperone regulation of the heat shock protein response
    Richard Voellmy
    HSF Pharmaceuticals SA, Avenue des Cerisiers 39B, 1009 Pully, Switzerland
    Adv Exp Med Biol 594:89-99. 2007
    ..CHIP can activate HSF1 to regulate the protein quality control system that balances protection and degradation of chaperone substrates...
  68. ncbi Requirement for Hsp90 and a CyP-40-type cyclophilin in negative regulation of the heat shock response
    A A Duina
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 273:18974-8. 1998
    The heat shock response is a highly conserved mechanism that allows cells to withstand a variety of stress conditions...
  69. pmc Cytochrome c is released in a reactive oxygen species-dependent manner and is degraded via caspase-like proteases in tobacco Bright-Yellow 2 cells en route to heat shock-induced cell death
    Rosa Anna Vacca
    Istituto di Biomembrane e Bioenergetica, Consiglio Nazionale delle Ricerche, I 70126 Bari, Italy
    Plant Physiol 141:208-19. 2006
    ..We conclude that ROS can trigger release of cyt c, but do not cause cell death, which requires caspase-like activation...
  70. ncbi The heat shock response of Synechocystis sp. PCC 6803 analysed by transcriptomics and proteomics
    Iwane Suzuki
    Graduate School of Life and Environmental Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba shi Ibaraki ken 305 8572, Japan
    J Exp Bot 57:1573-8. 2006
    ..However, the level of elongation factors are mainly regulated at the protein level. These results indicated that acclimation to the heat-shock conditions might be governed by transcriptional and translational regulation in Synechocystis...
  71. ncbi Phosphorylation-mediated regulation of heat shock response in Escherichia coli
    Gracjana Klein
    Departement de Biochimie Medicale, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneve 4, Switzerland
    Mol Microbiol 48:269-85. 2003
    ..The rpoH Tyr-260Ala mutation confers a temperature-sensitive phenotype that leads to an altered heat shock response. Additionally, we show that the antisigma factor RseA is phosphorylated at the N-terminally located Tyr-38 ..
  72. ncbi Identification and transcriptional characterization of the gene encoding the stress-response sigma factor sigma(H) in streptomyces coelicolor A3(2)
    J Kormanec
    Institute of Molecular Biology, Slovak Academy of Sciences, Dubravska cesta 21, 842 51, Bratislava, Slovak Republic
    FEMS Microbiol Lett 189:31-8. 2000
    ..The other three promoters (P2, P3, and P4) were located upstream of ushX, and were differentially induced after various stress conditions. The magnitude of the induction was greatest after osmotic stress and heat shock...
  73. ncbi Detecting ATM-dependent chromatin modification in DNA damage and heat shock response
    Sandeep Misri
    Washington University School of Medicine, St Louis, MO, USA
    Methods Mol Biol 523:395-410. 2009
    ..This review summarizes the multiple approaches used to discern the role of ATM in chromatin modification in response to DNA damage as well as heat shock...
  74. ncbi CoREST represses the heat shock response mediated by HSF1
    Andrea V Gómez
    Millenium Nucleus in Stress and Addiction, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 8330025, Chile
    Mol Cell 31:222-31. 2008
    ..we show that CoREST is bound to the hsp70 gene promoter under basal conditions and that its binding increases during heat shock response. In conclusion, we demonstrated that CoREST is a key regulator of the heat shock stress response.
  75. ncbi Identification of genes that modify ataxin-1-induced neurodegeneration
    P Fernandez-Funez
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 408:101-6. 2000
    ..These findings may be relevant to the treatment of polyglutamine diseases and, perhaps, to other neurodegenerative diseases, such as Alzheimer's and Parkinson's disease...
  76. ncbi Heat shock regulation in the ftsH null mutant of Escherichia coli: dissection of stability and activity control mechanisms of sigma32 in vivo
    T Tatsuta
    Department of Molecular Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto 862 0976, Japan
    Mol Microbiol 30:583-93. 1998
    The heat shock response of Escherichia coli is regulated by the cellular level and the activity of sigma32, an alternative sigma factor for heat shock promoters...
  77. ncbi Folding properties of the nucleotide exchange factor GrpE from Thermus thermophilus: GrpE is a thermosensor that mediates heat shock response
    Y Groemping
    Department of Physical Biochemistry, Max-Planck-Institute for Molecular Physiology, Otto-Hahn-Str. 11, D-44227 Dortmund, Germany
    J Mol Biol 314:167-78. 2001
    ....
  78. ncbi Self-association and chaperone activity of Hsp27 are thermally activated
    Barbara Lelj-Garolla
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 281:8169-74. 2006
    ..number of oligomerization states and that the range of oligomer size and the magnitude of chaperone activity increase significantly as temperature is increased over the range that is relevant to the physiological heat shock response.
  79. ncbi Gut myoelectrical activity induces heat shock response in Escherichia coli and Caco-2 cells
    Daniel Laubitz
    The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 02 106 Warsaw, Poland
    Exp Physiol 91:867-75. 2006
    The heat shock response is associated with the intracellular expression of a number of highly conserved heat shock proteins (Hsps)...
  80. ncbi Dynamics of heat shock factor association with native gene loci in living cells
    Jie Yao
    Field of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Nature 442:1050-3. 2006
    ..Our method can be applied to study the dynamics of many factors involved in transcription and RNA processing, and in their regulation at native heat shock genes in vivo...
  81. pmc The role of heat shock transcription factor 1 in the genome-wide regulation of the mammalian heat shock response
    Nathan D Trinklein
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    Mol Biol Cell 15:1254-61. 2004
    ..We characterized the heat shock response of mammalian cells by measuring changes in transcript levels and assaying binding of HSF1 to promoter ..
  82. ncbi Proteomic analysis of the heat shock response in Synechocystis PCC6803 and a thermally tolerant knockout strain lacking the histidine kinase 34 gene
    Antoni R Slabas
    School of Biological and Biomedical Sciences, University of Durham, Durham, UK
    Proteomics 6:845-64. 2006
    Proteomic analysis of the heat shock response of wild type and a mutant of the histidine kinase 34 gene (Deltahik34), which shows increased thermal tolerance, has been performed in the cyanobacterium Synechocystis sp. PCC6803...
  83. ncbi Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci
    Alexei Tulin
    Howard Hughes Medical Research Laboratories, Embryology Department, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Science 299:560-2. 2003
    ..Such local loosening may facilitate transcription and may transiently make protein complexes more accessible to modification, promoting chromatin remodeling during development...
  84. ncbi Hsf1p and Msn2/4p cooperate in the expression of Saccharomyces cerevisiae genes HSP26 and HSP104 in a gene- and stress type-dependent manner
    M Amoros
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Biologicas, Universitat de Valencia, Spain
    Mol Microbiol 39:1523-32. 2001
    ..Analysis of the stress-induced expression of two of these genes, HSP26 and HSP104, reveals that the contribution of Hsf1p and Msn2/4p is different depending on the gene and the stress condition...
  85. pmc The cytosolic protein response as a subcomponent of the wider heat shock response in Arabidopsis
    Akiko Sugio
    John Ines Centre, Colney, Norwich NR4 7UH, United Kingdom
    Plant Cell 21:642-54. 2009
    ..Characterization of Arabidopsis HSFA2 knockout and overexpression lines showed that HSFA2 is one of the regulatory components of the CPR...
  86. ncbi Heat shock response protects human peritoneal mesothelial cells from dialysate-induced oxidative stress and mitochondrial injury
    Hung Tien Kuo
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Faculty of Renal Care, Kaohsiung Medical University, Kaohsiung, Taiwan
    Nephrol Dial Transplant 24:1799-809. 2009
    ..However, the peritoneal mesothelial cells (PMCs) are subject to the injury by bioincompatible dialysates. The aim of this study is to investigate the protective roles and mechanisms of heat shock response in PMCs.
  87. ncbi TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response
    Juhee Park
    Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138 736, Republic of Korea
    Biochem Biophys Res Commun 360:447-52. 2007
    ..Here, we show that TC1 is upregulated by various cellular stresses and mediates heat shock response. Heat shock and other cellular stresses including H2O2, 12-O-tetradecanoylphorbol 13-acetate (TPA), ..
  88. ncbi Stressor-dependent regulation of the heat shock response in zebrafish, Danio rerio
    Susanna Airaksinen
    Department of Biology, Laboratory of Animal Physiology, University of Turku, FIN 20014 Turku, Finland
    Comp Biochem Physiol A Mol Integr Physiol 134:839-46. 2003
    ..Thus, hsp70 appears to be more weakly induced upon metal exposure than in response to heat shock and HSF1 isoforms may participate in stressor-specific regulation of hsp70...
  89. ncbi Heat stress-induced H(2)O (2) is required for effective expression of heat shock genes in Arabidopsis
    Roman A Volkov
    Zentrum fur Molekularbiologie der Pflanzen Allgemeine Genetik, Universitat Tubingen, Auf der Morgenstelle 28, 72076 Tubingen, Germany
    Plant Mol Biol 61:733-46. 2006
    ..The heat stress induction of a high mobility HSE-binding complex, characteristic for later phase of heat shock response, was blocked by ascorbate and DPI...
  90. ncbi Downregulation of the heat shock response is independent of DnaK and sigma32 levels in Caulobacter crescentus
    Antonio C A da Silva
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, C P 26077, Sao Paulo, SP, 05513 970, Brazil
    Mol Microbiol 49:541-53. 2003
    ..Despite the strong effect of DnaK levels on the induction phase of the heat shock response, downregulation of HSP synthesis was not affected by changes in the amount this chaperone...
  91. pmc Genetic modification of the Salmonella membrane physical state alters the pattern of heat shock response
    Amalia Porta
    University of Salerno, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Division of Biomedicine, Salerno, Italy
    J Bacteriol 192:1988-98. 2010
    ..These results represent a previously unrecognized mode of sensing temperature variation used by this pathogen at the onset of infection...
  92. ncbi Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease
    A Sittler
    , Ihnestrasse 73, D-14195 Berlin, Germany
    Hum Mol Genet 10:1307-15. 2001
    ..Geldanamycin is a benzoquinone ansamycin that binds to the heat shock protein Hsp90 and activates a heat shock response in mammalian cells...
  93. pmc A chaperone pathway in protein disaggregation. Hsp26 alters the nature of protein aggregates to facilitate reactivation by Hsp104
    Anil G Cashikar
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02143, USA
    J Biol Chem 280:23869-75. 2005
    ..Hence, Hsp26 plays an important role in pathways that defend cells against environmental stress and the types of protein misfolding seen in neurodegenerative disease...
  94. ncbi HSF recruitment and loss at most Drosophila heat shock loci is coordinated and depends on proximal promoter sequences
    L S Shopland
    Section of Biochemistry, Molecular and Cell Biology, 417 Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    Chromosoma 105:158-71. 1996
    The heat shock response in Drosophila is primarily dependent on the binding of the heat shock transcription factor, HSF, to conserved sequences in heat shock gene promoters, the heat shock elements (HSEs)...
  95. pmc Integrative analysis of the heat shock response in Aspergillus fumigatus
    Daniela Albrecht
    Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
    BMC Genomics 11:32. 2010
    ..fumigatus. The study was augmented by bioinformatical analysis of transcription factor binding sites (TFBSs) in the promoter region of genes whose corresponding proteins were differentially regulated upon heat shock...
  96. ncbi Role of the 3'-untranslated region of human endothelin-1 in vascular endothelial cells. Contribution to transcript lability and the cellular heat shock response
    Imtiaz A Mawji
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada
    J Biol Chem 279:8655-67. 2004
    ..Furthermore, DE1 functions as an ARE directing mRNA half-life through the proteasome. Finally, this data provides evidence for a novel pathway of ET-1 mRNA stabilization by heat shock...
  97. pmc Cisplatin abrogates the geldanamycin-induced heat shock response
    Andrea K McCollum
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Mol Cancer Ther 7:3256-64. 2008
    ..that results from treatment with Hsp90-targeted agents is the induction of a heat shock factor-1 (HSF-1) heat shock response. Treatment with GA + CDDP revealed that CDDP suppresses up-regulation of HSF-1 transcription, causing ..
  98. ncbi Inhibition of cyclooxygenase-2 gene expression by the heat shock response in J774 murine macrophages
    Armando Ialenti
    Department of Experimental Pharmacology, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
    Eur J Pharmacol 509:89-96. 2005
    The heat shock response is a highly conserved mechanism of protection elicited in the cell by various kinds of stimuli, such as heat, sodium arsenite, oxidants and inflammation...
  99. ncbi Stochastic modelling of the eukaryotic heat shock response
    Andrzej Mizera
    Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawinskiego 5B, 02 106 Warsaw, Poland
    J Theor Biol 265:455-66. 2010
    The heat shock response (HSR) is a highly evolutionarily conserved defence mechanism allowing the cell to promptly react to elevated temperature conditions and other forms of stress...
  100. ncbi Heat shock response inhibits IL-18 expression through the JNK pathway in murine peritoneal macrophages
    Yun Wang
    Department of Cell Biology, The Third Military Medical University, Chongqing 400038, China
    Biochem Biophys Res Commun 296:742-8. 2002
    b>Heat shock response has been implicated in cytoprotective effects from cellular damage and in the regulation of cytokine expression...
  101. ncbi Celastrols as inducers of the heat shock response and cytoprotection
    Sandy D Westerheide
    Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    J Biol Chem 279:56053-60. 2004
    ..from Chinese herbal medicine identified in a screen of bioactive small molecules that activates the human heat shock response. From a structure/function examination, the celastrol structure is remarkably specific and activates heat ..

Research Grants63

  1. IGFBP-5 and Hsp70 in Extracellular Matrix Homeostasis and Fibrosis
    Kristen L Veraldi; Fiscal Year: 2013
    ..these studies will provide mechanistic insight into the IGFBP-5 pro-fibrotic cascade and the role of the heat shock response in ECM deposition, leading to an enhanced understanding of the derangements in extracellular matrix ..
  2. Mechanism of PsrP mediated adhesion
    Carlos J Orihuela; Fiscal Year: 2013
    ..We will determine if passive vaccination with mAbs and active vaccination with recombinant BR constructs protects mice against pneumococcal challenge. ..
  3. Dynamics of Transcriptional Regulation
    Elena Zelin; Fiscal Year: 2011
    ..Hence, investigation of molecular mechanisms of transcriptional control will potentially facilitate design of drug-and gene-based therapeutic strategies to treat these abnormalities. ..
  4. A novel treatment, TAT-HSP70, in attenuating lung injury in sepsis induced ARDS
    MARY MELANIE LYONS; Fiscal Year: 2012
    ..One highly conserved endogenous mechanism that protects cells from injury is the Heat Shock Response (HSR) expressing HSPs. Our research focuses on the benefits of one specific family of HSPs, HSP70...
  5. Cell non-autonomous nature of the heat shock response
    PETER MAHAN DOUGLAS; Fiscal Year: 2013
    ..These will greatly facilitate Dr. Douglas'transition and success as an independent investigator. ..
  6. Testing of novel anti-cancer compounds Curaxins against pancreatic cancer
    Katerina Gurova; Fiscal Year: 2013
    ..b>Heat shock response, mediated by HSF1, is frequently overactive in PDA cells...
  7. TRANSMEMBRANE SIGNAL MODULATION BY HYPERTHERMIA
    STUART KEITH CALDERWOOD; Fiscal Year: 2013
    ..It is thus desirable to understand the regulation of the heat shock response. Our hypothesis is that hyperthermia and pro-degenerative stresses trigger HSP expression through ..
  8. CD14: Biosynthesis, Trafficking and Secretion
    DIEGO FERNANDO NINO; Fiscal Year: 2013
    ..Thus, Mos treated with GA show an impaired response to LPS.(5) In addition, GA is a potent inducer of the heat shock response.(6) Thus, the effect of GA on CD14 internalization could be due to inhibition of Hsp90 function or heat ..
  9. PARP-1 is a Negative Modulator of the Heart Shock Response
    RAJESH K ANEJA; Fiscal Year: 2010
    ..My research project "Poly (ADP-ribose) polymerase (PARP) -1 is a negative modulator of the heat shock response" is designed to both provide vital new information and serve as an educational opportunity that compliments ..
  10. REGULATION OF THE HEAT SHOCK RESPONSE IN E. COLI
    CAROL ANNE GROSS; Fiscal Year: 2013
    ..We will continue to dissect the process interconnections we have identified and also perform comparable studies in B. subtilis, to uncover common and unique strategies to this universal stress. ..
  11. Mechanisms of lack of senescence and inducible senescence in the genus Hydra
    Daniel E Martinez; Fiscal Year: 2013
    ..which inducibly overexpress genes of interest, we will investigate the roles of genes involved in the heat shock response and the role of the transcription factor FoxO in H. vulgaris and in H...
  12. Development of a zebrafish assay for the identification of ALS drug targets
    Christine E Beattie; Fiscal Year: 2010
    ..Upon identifying the transgenic lines, we found that the fish carrying the sod1 mutations turned on the heat shock response, as revealed by DsRed expression, independent of heat shock (referred to as sodmut hsp70 induction)...
  13. Chaperone therapeutics for the treatment of DPN
    Rick T Dobrowsky; Fiscal Year: 2013
    ..It is also the master regulator of a cytoprotective "heat shock response", which aids the refolding of aggregated and damaged proteins that occur upon cell stress...
  14. Discovering small molecules activators of stress responsive signaling
    Jeffery W Kelly; Fiscal Year: 2013
    ..A prior cell-based heat shock response (influencing cytosolic proteostasis) activator reporter screen has generated numerous small molecule leads ..
  15. Chaperones in Diabetic Peripheral Neuropathy
    Rick T Dobrowsky; Fiscal Year: 2013
    ..Hsp90 is the master regulator of the cytoprotective heat shock response, which upregulates expression of Hsp70 and antioxidant genes...
  16. Mechanistic basis and potential therapies for myosin storage myopathy
    Sanford I Bernstein; Fiscal Year: 2013
    ..known to aid in myosin folding and/or protection from stress);b) by using small molecule inducers of the heat shock response to more broadly elicit expression of molecular chaperones;c) by using transgenic or pharmacological ..
  17. Hsp90 inhibitors to combat antifungal drug resistance.
    ESTEBAN EDWARD MENA; Fiscal Year: 2012
    ..As a result, known Hsp90 inhibitors, such as geldanamycin, induce the heat shock response, an overexpression of Hsp90, Hsp70, and other co-chaperones...
  18. A Systems Approach to Stress Biology and Proteostasis Networks
    Richard I Morimoto; Fiscal Year: 2013
    ..transmit the thermosensory signal from the AFD neurons to regulate the cell non-autonomous control of the heat shock response and HSF1 activity in somatic cells, (2) At the cellular level, to characterize the tissue-specific ..
  19. Large Scale Identification and Characterization of Hsf1-mediated Heat Shock Respo
    PATRICK ALLEN GIBNEY; Fiscal Year: 2012
    ..The conserved heat shock response in Saccharomyces cerevisiae has proven to be a paradigm for general eukaryotic stress responses...
  20. Targeting the heat shock response for the therapy of DLBCL
    Ari M Melnick; Fiscal Year: 2013
    ....
  21. Heat Shock Directed Drug Discovery For The Treatment Of Gliomas
    Sandro Santagata; Fiscal Year: 2012
    ..of non-oncogene addiction, Heat Shock Factor 1 (HSF1), the main transcription factor regulating the heat shock response (HSR), which acts a powerful multifaceted regulator of signaling pathways relevant to gliomagenesis...
  22. Genetic Control of Aging in C. elegans
    Cynthia J Kenyon; Fiscal Year: 2013
    ..Together these studies may ultimately define new therapeutic strategies for combating age-related disease and increasing the quality of old age. ..
  23. Heat shock proteins in signaling and cancer
    Michael Y Sherman; Fiscal Year: 2013
    ..A critical aspect of this work will be investigation the effects of NZ28, a novel inhibitor of the heat shock response developed by us, on tumors in animals...
  24. Quantitative approaches to reveal the homeostatic control mechanisms of stress re
    David Pincus; Fiscal Year: 2013
    ..In the first two aims I will focus on the heat shock response, the elemental and and prototypical stress response, to reveal how phosphorylation and chaperone protein ..
  25. HSP60, Inflammation and Cardiovascular Disease
    Anne A Knowlton; Fiscal Year: 2013
    ..SA3 - Investigate the role of HSP60 in Repetitive Injury and the Heat Shock Paradox - The heat shock response is protective, and yet, when the heat shock response is induced after an inflammatory stress, rather than ..
  26. C/EBP and IL-6 Production in Mucosa and Enterocytes
    Per Olof Hasselgren; Fiscal Year: 2006
    ..with increased production of IL-6 in intestinal mucosa and enterocytes, a response that is augmented by the heat shock response. IL-6, locally produced in the mucosa, may regulate the synthesis of acute phase proteins in enterocytes ..
  27. ANTIFUNGAL RESPONSE--MDR INDUCTION
    Thomas Edlind; Fiscal Year: 2002
    ..This "antifungal response" would be analogous to, but mechanistically distinct from, the heat shock response. The focus of this proposal is one such antifungal response, termed MDR induction, involving the rapid drug-..
  28. Elucidating the stress response regulatory networks that enable malignancy
    MARC MENDILLO; Fiscal Year: 2013
    ..Understanding the regulatory hub of the HSF1 network and how its activation enables a particularly aggressive type of malignancy is of immense clinical importance. ..
  29. TAS::75 0849::TAS SBIR TOPIC 255 PHASE II DEVELOPMENT OF ANTICANCER AGENTS
    CATHERINE BURKHART; Fiscal Year: 2011
    Aberrant functioning of proteins within stress response pathways (e.g. p53, NF-B, heat shock response) are prominent features in many cancer types...
  30. Inhibiting the heat shock factor 1-regulated transcriptional program in cancer
    Luke J Whitesell; Fiscal Year: 2013
    ..In previous work we have demonstrated that Heat Shock Factor 1 (HSF1), master regulator of the mammalian heat shock response acts in a powerful, multi-faceted manner to enable malignant transformation both in cell culture and in ..
  31. MECHANISMS OF HUNTINGTIN-INDUCED NEURODEGENERATION
    Steven M Finkbeiner; Fiscal Year: 2013
    ..The highly conserved heat shock response mediates responses to misfolded proteins in most cells, but it seems different and ineffective in neurons...
  32. FRACTIONATED HYPERTHERMIA AND HEAT SHOCK PROTEINS
    Gloria Li; Fiscal Year: 1999
    ..will test a hypothesis inferred from our preliminary studies that there is a dual control mechanism in the heat shock response: a positive control mediated via the heat shock transcription factor HSF1, and a negative control mediated ..
  33. Celestrols for Treatment of Neurodegenerative Diseases
    Richard Silverman; Fiscal Year: 2007
    ..A search was carried out for drugs that activate the heat shock response; the most effective compound identified was the natural product celastrol...
  34. Development of Hsp90 inhibitors for the treatment of cancer
    Brian S J Blagg; Fiscal Year: 2013
    ..In contrast to N-terminal inhibitors that induce the pro-survival heat shock response, C-terminal inhibitors do not, and therefore provide a new paradigm in cancer research...
  35. Analyzing inoculum effect and optimal design of antibiotic treatment
    Lingchong You; Fiscal Year: 2013
    ..of inoculum effect is fast degradation of the ribosomal components induced by the antibiotic via the heat shock response;(2) the inoculum effect can drastically affect efficacy of antibiotic treatment...
  36. The heat shock response and cytoprotection
    Hector Wong; Fiscal Year: 2006
    The heat shock response (HSR) is a primitive cellular defense mechanism that is known to occur in critically ill patients...
  37. REGULATION OF BACTERIAL METABOLISM
    FREDERICK NEIDHARDT; Fiscal Year: 1992
    ..ln addition, the heat-shock response has human medical implications for bacterial and virus infections, for environmentally induced birth defects, for tumor chemotherapy, and for cell responses to environmental stress...
  38. HEAT SHOCK PROTEINS IN E COLI CELL ENVELOPE
    MARY LUCKEY; Fiscal Year: 1993
    Characterization of the heat shock response in Escherichia coli has allowed identification of at least twenty heat shock proteins (hsps), some of which are essential for viability at normal temperatures. About half of the hsps in E...
  39. Identifying Small Molecules To Probe the Role of Heat Shock Factor 1 in Cancer
    Luke Whitesell; Fiscal Year: 2009
    The heat shock response (HSR) is a powerful transcriptional program which acts genome-wide, not only to restore the normal protein folding environment through the induction of heat shock proteins but as more recent work has shown to re-..
  40. Role of Heat Shock Response in a Zoonotic Virus
    Brian Hjelle; Fiscal Year: 2002
    ..abstract_text> ..
  41. Identification of Stage Specific Genes in Leishmania
    Peter Myler; Fiscal Year: 2001
    ..It is likely to have sequence similarity/homology to those involved in signal transduction and heat shock response pathways in other organisms...
  42. The Mechanism of Heat Shock Activation
    Evgeny Nudler; Fiscal Year: 2007
    ..It is further proposed to design small modulators of heat shock response based on HSR antisense oligonucleotides for applications in cancer therapy. Specific aims are: I...
  43. GENETIC ANALYSIS OF TRANSLATION INITIATION IN YEAST
    Michael Hampsey; Fiscal Year: 1993
    ..In higher eukaryotes, genes involved in the heat shock response, light-induced developmental signals, and other processes are translationally regulated...
  44. SIGMA E-DEPENDENT HEAT SHOCK RESPONSE OF E COLI
    Dominique Missiakas; Fiscal Year: 2002
    ..The classical heat shock response is triggered by protein misfolding in the cytoplasm and is mediated by the RNA polymerase minor sigma ..
  45. Metal Toxicant Effects-Small Heat-Shock Protein Function
    Michael Welsh; Fiscal Year: 2005
    ..It is expected that these studies will contribute significantly to our understanding of sublethal effects of toxic metals (either singly or in combinations) and the function of sHSPs in muscle and kidney. ..
  46. MOLECULAR CHAPERONE'S AND THE HEAT SHOCK RESPONSE
    TERRI GRODZICKER; Fiscal Year: 2000
    ..abstract): This is a proposal for partial financial support for a meeting on Molecular Chaperones and the Heat Shock Response to be held from May 3-7, 200, at Cold Spring Harbor Laboratory...
  47. MOLECULAR CHAPERONE'S AND THE HEAT SHOCK RESPONSE
    TERRI GRODZICKER; Fiscal Year: 2002
    This proposal is a request for partial financial support for a meeting on MOLECULAR CHAPERONES AND THE HEAT SHOCK RESPONSE to be held from May 1- May 5, 2002 at Cold Spring Harbor Laboratory...
  48. THE HEAT SHOCK RESPONSE: POTENTIAL TO SCREEN TERATOGENS
    Richard Finnell; Fiscal Year: 1990
    ....
  49. TRANSCRIPTIONAL REGULATION OF PLANT HEAT SHOCK GENES
    WILLIAM GURLEY; Fiscal Year: 1992
    ..This class contains from 20to 30 proteins that predominate the heat shock response in soybean and other plants (1,2). Gmhsp 17...
  50. HEAT SHOCK PROTEINS IN SERTOLI CELL TOXICITY
    MICHAEL BRABEC; Fiscal Year: 1992
    ..This proposal examines the hypothesis that the induction of the heat shock response in testicular cells is a critical step in the mechanism of heat - and chemical-induced inhibition of ..
  51. Suppression of the heat shock response in aging and neurodegeneration
    Michael Sherman; Fiscal Year: 2009
    ..The heat shock response (HSR) is also strongly downregulated in aged organisms and senescent cells...
  52. REGULATION OF P AERUGINOSA VIRULENCE FACTORS BY VFR
    Susan West; Fiscal Year: 2001
    ..not limited to those involved in nutrient assimilation, flagellum synthesis, enterotoxin production and the heat shock response. The investigator has found that Vfr, in P...
  53. Treatment of Demyelinating Disease with HSP90 Inhibitors
    Douglas L Feinstein; Fiscal Year: 2010
    ..We and others have shown that induction of a heat shock response (HSR) potently reduced activation of transcription factor NFkB and inflammatory gene expression in brain ..
  54. MECHANISMS OF BLEOMYCIN LUNG DISEASE
    Pope Moseley; Fiscal Year: 1992
    ..The studies described in this proposal are designed to characterize the nature of the heat shock response to bleomycin and to determine how this response is regulated...
  55. Gene Expression Profiling in Aging Human Skeletal Muscle
    SUSAN KANDARIAN; Fiscal Year: 2003
    ..men, skeletal muscle from older healthy men will exhibit an upregulation of the stress response genes (heat shock response, DNA damage-inducible, oxidative stress-inducible), upregulation of genes associated with neuronal injury, ..
  56. The role of I-kappaB in control of glial inflammation
    Douglas Feinstein; Fiscal Year: 2006
    ..We showed two mechanisms toreduce NOS2, incubation with Norepinephrine (NE) or induction of a heat shock response (HSR),whether these methods prevent human glial NOS2 is not known...
  57. ANALYSIS OF THE HEAT SHOCK RESPONSE IN E. COLI
    Dana Carroll; Fiscal Year: 1993
    ..This system may provide insight into the mechanisms by which animal viruses, such as adenovirus, polyoma, and SV40, induce the synthesis of certain host hs proteins during infection. ..
  58. MOLECULAR MECHANISM OF HEAT SHOCK RESPONSE IN DROSOPHILA
    VICTOR CORCES; Fiscal Year: 1990
    ..From the correlation between the molecular lesion and the particular phenotype, we will be able to assign functional roles to different DNA sequences involved in control of transcription...
  59. MOLECULAR AND GENETIC DISSECTION OF GENE REGULATION
    James Bonner; Fiscal Year: 1990
    ..The heat shock response is one such network wherein hyperthermic stress induces the synthesis of the "heat shock proteins," or hsps...
  60. GLIAL NO SYNTHASE--REGULATION OF EXPRESSION
    Douglas Feinstein; Fiscal Year: 1999
    ..They will also test if NE induces IkB expression. They will fully characterize the heat shock response in astrocyte and C6 cells with the purpose of defining which heat shock proteins can block NOS-2 induction, ..
  61. Inhibitors of Heat Shock Response
    ANDREY KOMAROV; Fiscal Year: 2009
    ..of anti-cancer pharmaceuticals has resulted in the isolation of several effective blockers of constitutive heat shock response (HSR), such as the HSP90 inhibitor Geldanamycin (DMAG) and the proteasome inhibitor Velcade (Bortezomib), ..
  62. Drug Targets of Heat Shock Response
    ANDREY KOMAROV; Fiscal Year: 2009
    The heat shock response (HSR) induced by cell stress is a common protection mechanism elicited in a wide range of tumors. This response is closely associated with a poor prognosis and resistance to therapy...
  63. Chromatin remodeling and gene regulation in Drosophila
    Steven Mauro; Fiscal Year: 2004
    ..phosphorylation correlate with increased transcription at heat shock loci in Drosophila following a heat shock response. Our objective is to understand how these processes function in transcriptional regulation of the hsp70 ..