Genomes and Genes
Summary: The processes whereby the internal environment of an organism tends to remain balanced and stable.
Publications329 found, 100 shown here
- Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalizationElizabeta Nemeth
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Science 306:2090-3. 2004..The posttranslational regulation of ferroportin by hepcidin may thus complete a homeostatic loop: Iron regulates the secretion of hepcidin, which in turn controls the concentration of ferroportin on the cell surface...
- Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in manD R Matthews
Diabetologia 28:412-9. 1985..of the contributions of insulin resistance and deficient beta-cell function to the fasting hyperglycaemia (homeostasis model assessment, HOMA)...
- Hepcidin and iron homeostasisTomas Ganz
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Biochim Biophys Acta 1823:1434-43. 2012..Hepcidin, ferroportin and their regulators represent potential targets for the diagnosis and treatment of iron disorders and anemias. This article is part of a Special Issue entitled: Cell Biology of Metals...
- Macrophage biology in development, homeostasis and diseaseThomas A Wynn
Immunopathogenesis Section, Program in Tissue Immunity and Repair and Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20877 8003, USA
Nature 496:445-55. 2013..They have roles in development, homeostasis, tissue repair and immunity...
- Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signalingPaul D Ray
Department of Environmental and Molecular Toxicology, North Carolina State University, Campus Box 7633, Raleigh, NC 27695 7633, USA
Cell Signal 24:981-90. 2012..such as proliferation and survival (MAP kinases, PI3 kinase, PTEN, and protein tyrosine phosphatases), ROS homeostasis and antioxidant gene regulation (thioredoxin, peroxiredoxin, Ref-1, and Nrf-2), mitochondrial oxidative stress, ..
- Regulation of cell death: the calcium-apoptosis linkSten Orrenius
Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, SE 171 77 Stockholm, Sweden
Nat Rev Mol Cell Biol 4:552-65. 2003..However, more recently it has become clear that cellular Ca2+ overload, or perturbation of intracellular Ca2+ compartmentalization, can cause cytotoxicity and trigger either apoptotic or necrotic cell death...
- Adipocytes as regulators of energy balance and glucose homeostasisEvan D Rosen
Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Centre, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Nature 444:847-53. 2006..Adipose tissue also serves as a crucial integrator of glucose homeostasis. Knowledge of adipocyte biology is therefore crucial for understanding the pathophysiological basis of obesity ..
- Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesUmut Ozcan
Department of Genetics and Complex Diseases, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
Science 313:1137-40. 2006..Our results demonstrate that chemical chaperones enhance the adaptive capacity of the ER and act as potent antidiabetic modalities with potential application in the treatment of type 2 diabetes...
- Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1Joseph T Rodgers
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 434:113-8. 2005..Thus, we have identified a molecular mechanism whereby SIRT1 functions in glucose homeostasis as a modulator of PGC-1alpha...
- ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasisMichel B Toledano
CEA, iBiTecS, SBIGeM, Laboratoire Stress Oxydants et Cancer, Batiment 142, Commissariat à l Energie Atomique Saclay, 91191 Gif sur Yvette, France
Nat Rev Mol Cell Biol 8:813-24. 2007..The pathways that regulate ROS homeostasis are crucial for mitigating the toxicity of ROS and provide strong evidence about specificity in ROS signalling...
- The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsIvaylo I Ivanov
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Cell 126:1121-33. 2006..Together, these studies suggest that RORgammat is a key regulator of immune homeostasis and highlight its potential as a therapeutic target in inflammatory diseases.
- Tensional homeostasis and the malignant phenotypeMatthew J Paszek
Department of Bioengineering, University of Pennsylvania, Philadelphia, 19104, USA
Cancer Cell 8:241-54. 2005..Thus, ERK and Rho constitute part of an integrated mechanoregulatory circuit linking matrix stiffness to cytoskeletal tension through integrins to regulate tissue phenotype...
- Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasisSimon Yona
Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
Immunity 38:79-91. 2013....
- Evidence for osteocyte regulation of bone homeostasis through RANKL expressionTomoki Nakashima
Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo, Japan
Nat Med 17:1231-4. 2011Osteocytes embedded in bone have been postulated to orchestrate bone homeostasis by regulating both bone-forming osteoblasts and bone-resorbing osteoclasts...
- Sleep function and synaptic homeostasisGiulio Tononi
Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719, USA
Sleep Med Rev 10:49-62. 2006This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis...
- Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesitySuneng Fu
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Nature 473:528-31. 2011..synthesis, membrane biogenesis, xenobiotic detoxification and cellular calcium storage, and perturbation of ER homeostasis leads to stress and the activation of the unfolded protein response...
- The self-tuning neuron: synaptic scaling of excitatory synapsesGina G Turrigiano
Department of Biology, Volen Center for Complex Systems, and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
Cell 135:422-35. 2008..Additional mechanisms may allow local or network-wide changes in activity to be sensed through parallel pathways, generating a nested set of homeostatic mechanisms that operate over different temporal and spatial scales...
- Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasisCongcong He
Center for Autophagy Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Nature 481:511-5. 2012..Thus, exercise induces autophagy, BCL2 is a crucial regulator of exercise- (and starvation)-induced autophagy in vivo, and autophagy induction may contribute to the beneficial metabolic effects of exercise...
- Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancerPeter M Siegel
Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Nat Rev Cancer 3:807-21. 2003
- Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivityE Bonora
Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Italy
Diabetes Care 23:57-63. 2000To evaluate whether the homeostasis model assessment (HOMA) is a reliable surrogate measure of in vivo insulin sensitivity in humans.
- MiR-33 contributes to the regulation of cholesterol homeostasisKatey J Rayner
Department of Medicine, Leon H Charney Division of Cardiology and the Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, NY 10016, USA
Science 328:1570-3. 2010..Conversely, silencing of miR-33 in vivo increases hepatic expression of ABCA1 and plasma HDL levels. Thus, miR-33 appears to regulate both HDL biogenesis in the liver and cellular cholesterol efflux...
- Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisShuo Chien Ling
Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093 0670, USA
Neuron 79:416-38. 2013..Dysfunction in RNA processing and protein homeostasis is an emerging theme...
- The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammationMeghan A Koch
Benaroya Research Institute, Seattle, Washington, USA
Nat Immunol 10:595-602. 2009Several subsets of Foxp3(+) regulatory T cells (T(reg) cells) work in concert to maintain immune homeostasis. However, the molecular bases underlying the phenotypic and functional diversity of T(reg) cells remain obscure...
- A single type of progenitor cell maintains normal epidermisElizabeth Clayton
MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge CB2 0XZ, UK
Nature 446:185-9. 2007According to the current model of adult epidermal homeostasis, skin tissue is maintained by two discrete populations of progenitor cells: self-renewing stem cells; and their progeny, known as transit amplifying cells, which differentiate ..
- Homeostasis and inflammation in the intestineWendy S Garrett
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Cell 140:859-70. 2010..In this Review, we consider the many cellular and molecular methods by which inflammatory responses are regulated to maintain intestinal homeostasis and the disease states that can ensue when this balance is lost.
- In vivo analysis of dendritic cell development and homeostasisKang Liu
Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA
Science 324:392-7. 2009..Further cDC development involves cell division, which is controlled in part by regulatory T cells and fms-like tyrosine kinase receptor-3...
- Immune adaptations that maintain homeostasis with the intestinal microbiotaLora V Hooper
The Howard Hughes Medical Institute and The Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, 75390, USA
Nat Rev Immunol 10:159-69. 2010..In this Review, we discuss the unique adaptations of the intestinal immune system that maintain homeostatic interactions with a diverse resident microbiota...
- Translational control is required for the unfolded protein response and in vivo glucose homeostasisD Scheuner
Howard Hughes Medical Institute, University of Michigan Medical Center, 48109, Ann Arbor, MI, USA
Mol Cell 7:1165-76. 2001..The results demonstrate that regulation of translation through eIF2alpha phosphorylation is essential for the ER stress response and in vivo glucose homeostasis.
- Intrinsic noise in gene regulatory networksM Thattai
Department of Physics, Room 13-2010, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 98:8614-9. 2001..The analysis of intrinsic noise reveals biological roles of gene network structures and can lead to a deeper understanding of their evolutionary origin...
- Autophagy for tissue homeostasis and neuroprotectionGuillermo Mariño
INSERM, U848, F 94805 Villejuif, France
Curr Opin Cell Biol 23:198-206. 2011..been viewed as a cell death mechanism in the mammalian system, it is now considered as indispensable for the homeostasis of cells, tissues, and organisms...
- Epidermal homeostasis: a balancing act of stem cells in the skinCedric Blanpain
Universite Libre de Bruxelles, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, 808, Route de Lennik, 1070 Bruxelles, Belgium
Nat Rev Mol Cell Biol 10:207-17. 2009The skin epidermis and its array of appendages undergo ongoing renewal by a process called homeostasis. Stem cells in the epidermis have a crucial role in maintaining tissue homeostasis by providing new cells to replace those that are ..
- A central role for JNK in obesity and insulin resistanceJiro Hirosumi
Division of Biological Sciences and Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
Nature 420:333-6. 2002..Thus, JNK is a crucial mediator of obesity and insulin resistance and a potential target for therapeutics...
- MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesisWei Chih Tsai
Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan
J Clin Invest 122:2884-97. 2012....
- Reactive oxygen species homeostasis and signalling during drought and salinity stressesGad Miller
Department of Biochemistry and Molecular Biology, University of Nevada, Reno, 89557, USA
Plant Cell Environ 33:453-67. 2010..in combination with other stresses, disrupt photosynthesis and increase photorespiration, altering the normal homeostasis of cells and cause an increased production of reactive oxygen species (ROS)...
- Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunityP Bouillet
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
Science 286:1735-8. 1999..Thus, Bim is required for hematopoietic homeostasis and as a barrier to autoimmunity...
- Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesUmut Ozcan
Department of Genetics and Complex Diseases, Harvard Medical School, Boston, MA 02115, USA
Science 306:457-61. 2004..Pharmacologic manipulation of this pathway may offer novel opportunities for treating these common diseases...
- Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasisDAVINA WU
Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143 0795, USA
Science 332:243-7. 2011..Adipose tissue AAMs are necessary to maintain glucose homeostasis and are induced by the cytokine interleukin-4 (IL-4)...
- Homeostasis of naive and memory T cellsCharles D Surh
The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
Immunity 29:848-62. 2008..Typical memory cells are kept alive and induced to divide intermittently by a mixture of IL-7 and IL-15. This review highlights recent advances in how naive and memory T cell homeostasis is regulated.
- Local sleep and learningReto Huber
Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
Nature 430:78-81. 2004..It has been suggested that SWA homeostasis may reflect synaptic changes underlying a cellular need for sleep...
- The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasisPatrick M Smith
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
Science 341:569-73. 2013..Our study reveals that a class of abundant microbial metabolites underlies adaptive immune microbiota coadaptation and promotes colonic homeostasis and health.
- Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanismsMing O Li
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Immunity 25:455-71. 2006..In addition, TGF-beta signaling positively regulated T cell development and homeostasis. Development of CD8+ T cells and NKT cells, maintenance of peripheral Foxp3-expressing regulatory T cells, and ..
- MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasisS Hani Najafi-Shoushtari
Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
Science 328:1566-9. 2010..Our findings indicate that miR-33 acts in concert with the SREBP host genes to control cholesterol homeostasis and suggest that miR-33 may represent a therapeutic target for ameliorating cardiometabolic diseases.
- Regulation of ion homeostasis under salt stressJian Kang Zhu
Department of Plant Sciences, University of Arizona, Tucson, Arizona 85721, USA
Curr Opin Plant Biol 6:441-5. 2003..The protein kinase complex then phosphorylates and activates various ion transporters, such as the plasma membrane Na(+)/H(+) antiporter SOS1...
- Tgf-beta superfamily signaling in embryonic development and homeostasisMary Y Wu
Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Dev Cell 16:329-43. 2009..that these pathways contribute to the increased diversity and complexity required for the development and homeostasis of these organisms...
- Redox homeostasis and antioxidant signaling: a metabolic interface between stress perception and physiological responsesChristine H Foyer
Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK
Plant Cell 17:1866-75. 2005
- NK cell development, homeostasis and function: parallels with CD8⁺ T cellsJoseph C Sun
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Nat Rev Immunol 11:645-57. 2011..In this Review, we highlight the many stages that an NK cell progresses through during its remarkable lifetime, discussing similarities and differences with its close relative, the cytotoxic CD8(+) T cell...
- LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in miceMartin C Herzig
Department of Neuroscience, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH 4002 Basel, Switzerland
Hum Mol Genet 20:4209-23. 2011..These novel aspects of peripheral LRRK2 biology critically impact ongoing attempts to develop LRRK2 selective kinase inhibitors as therapeutics for PD...
- Zinc homeostasis and signaling in health and diseases: Zinc signalingToshiyuki Fukada
Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, 230 0045, Japan
J Biol Inorg Chem 16:1123-34. 2011The essential trace element zinc (Zn) is widely required in cellular functions, and abnormal Zn homeostasis causes a variety of health problems that include growth retardation, immunodeficiency, hypogonadism, and neuronal and sensory ..
- Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cellsJonathan Sprent
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
Nat Immunol 12:478-84. 2011..The molecular mechanisms that control the conversion of naive resting T cells into memory-phenotype cells TCR-dependent in normal animals are beginning to be understood...
- Regulation of oxygen homeostasis by hypoxia-inducible factor 1Gregg L Semenza
Vascular Program, Institute for Cell Engineering, McKusick Nathans Institute of Genetic Medicine, Baltimore, Maryland, USA
Physiology (Bethesda) 24:97-106. 2009..Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates oxygen homeostasis and plays key roles in development, physiology, and disease...
- Alkali metal cation transport and homeostasis in yeastsJoaquin Arino
Departament de Bioquimica i Biologia Molecular, Ed V, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
Microbiol Mol Biol Rev 74:95-120. 2010..Similarly, very little is known about the regulation of organellar transport and homeostasis of alkali metal cations...
- Intestinal homeostasis and its breakdown in inflammatory bowel diseaseKevin J Maloy
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Nature 474:298-306. 2011Intestinal homeostasis depends on complex interactions between the microbiota, the intestinal epithelium and the host immune system...
- FOXOs: signalling integrators for homeostasis maintenanceAstrid Eijkelenboom
Molecular Cancer Research, Division Biomedical Genetics, University Medical Center Utrecht, Stratenum, Universiteitsweg 100, 3584CG Utrecht, The Netherlands
Nat Rev Mol Cell Biol 14:83-97. 2013..The diversity of this upstream regulation and the downstream effects of FOXOs suggest that they function as homeostasis regulators to maintain tissue homeostasis over time and coordinate a response to environmental changes, ..
- A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasisBong Hyun Ahn
Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 105:14447-52. 2008..These results implicate protein acetylation as an important regulator of Complex I activity and demonstrate that Sirt3 functions in vivo to regulate and maintain basal ATP levels...
- A receptor-mediated pathway for cholesterol homeostasisM S Brown
Science 232:34-47. 1986
- Unraveling mechanisms of homeostatic synaptic plasticityKarine Pozo
MRC Cell Biology Unit and MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK
Neuron 66:337-51. 2010..Here we review our current understanding of cellular and molecular mechanisms of homeostatic synaptic plasticity...
- Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repairAnne Wilson
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland
Cell 135:1118-29. 2008..While they form a silent reservoir of the most potent HSCs during homeostasis, they are efficiently activated to self-renew in response to bone marrow injury or G-CSF stimulation...
- FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasisJi Hye Paik
Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
Cell 128:309-23. 2007..Functional studies validated Sprouty2 and PBX1, among others, as FoxO-regulated mediators of endothelial cell morphogenesis and vascular homeostasis.
- The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and functionKai Yang
Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
Nat Immunol 12:888-97. 2011..complex mTORC1 but less mTORC2 activity, and activation of mTORC1 was essential for the disruption of immune homeostasis. Therefore, Tsc1-dependent control of mTOR is crucial in actively maintaining the quiescence of naive T cells ..
- Sleep and synaptic homeostasis: a hypothesisGiulio Tononi
Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719, USA
Brain Res Bull 62:143-50. 2003..Synaptic downscaling is tied to the beneficial effects of sleep on performance. The hypothesized link between sleep and synaptic homeostasis is supported by several lines of evidence and leads to testable predictions.
- Key role for gene dosage and synaptic homeostasis in autism spectrum disordersRoberto Toro
Human Genetics and Cognitive Functions, Institut Pasteur, 75015 Paris, France
Trends Genet 26:363-72. 2010..Finally, the broad expression and function of the causative genes suggest that alteration of synaptic homeostasis could be a common biological process associated with ASD...
- Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancerThomas R Cox
Cancer Research UK Tumour Cell Signalling Unit, Section of Cell and Molecular Biology, The Institute of Cancer Research, London, UK
Dis Model Mech 4:165-78. 2011..Dynamic remodeling of the extracellular matrix (ECM) is essential for development, wound healing and normal organ homeostasis. Life-threatening pathological conditions arise when ECM remodeling becomes excessive or uncontrolled...
- Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasisDjahida Bouskra
Institut Pasteur, Laboratory of Lymphoid Tissue Development, CNRS, URA1961
Nature 456:507-10. 2008Intestinal homeostasis is critical for efficient energy extraction from food and protection from pathogens...
- Epithelial barriers in homeostasis and diseaseAmanda M Marchiando
Department of Pathology, Graduate Program in Molecular Pathogenesis and Molecular Medicine, The University of Chicago, Chicago, Illinois, 60637, USA
Annu Rev Pathol 5:119-44. 2010..In this review, we discuss the critical roles of the tight junction in health and explore the contributions of barrier dysfunction to disease pathogenesis...
- AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stressSang Min Jeon
Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
Nature 485:661-5. 2012..Thus AMPK, in addition to its function in ATP homeostasis, has a key function in NADPH maintenance, which is critical for cancer cell survival under energy stress ..
- WNT signaling in bone homeostasis and disease: from human mutations to treatmentsRoland Baron
Department of Medicine, Harvard Medical School, Harvard University, Boston, Massachusetts, USA
Nat Med 19:179-92. 2013..Mouse genetics confirmed the importance of canonical Wnt signaling in the regulation of bone homeostasis, with activation of the pathway leading to increased, and inhibition leading to decreased, bone mass and ..
- Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virusLaurel A Monticelli
Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Nat Immunol 12:1045-54. 2011..orchestrating immunity and inflammation in the intestine, but whether ILCs influence immune responses or tissue homeostasis at other mucosal sites remains poorly characterized...
- Identification of a nuclear receptor for bile acidsM Makishima
Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9050, USA
Science 284:1362-5. 1999..These results demonstrate a mechanism by which bile acids transcriptionally regulate their biosynthesis and enterohepatic transport...
- A critical function for CD200 in lung immune homeostasis and the severity of influenza infectionRobert J Snelgrove
Imperial College London, Kennedy Institute, London, W6 8LH, UK
Nat Immunol 9:1074-83. 2008..Thus, CD200R is critical for lung macrophage immune homeostasis in the resting state and limits inflammatory amplitude and duration during pulmonary influenza infection.
- Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient miceL D Klaman
Cancer Biology Program, Division of Hematology Oncology, Boston, Massachusetts 02215, USA
Mol Cell Biol 20:5479-89. 2000..Our results identify PTP-1B as a major regulator of energy balance, insulin sensitivity, and body fat stores in vivo...
- MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptakeFabiana Perocchi
Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Nature 467:291-6. 2010..Its discovery may lead to the complete molecular characterization of mitochondrial calcium uptake pathways, and offers genetic strategies for understanding their contribution to normal physiology and disease...
- Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie systemHellmut G Augustin
Joint Research Division Vascular Biology, Medical Faculty Mannheim CBTM, University of Heidelberg, and German Cancer Research Center Heidelberg DKFZ ZMBH Alliance, Germany
Nat Rev Mol Cell Biol 10:165-77. 2009..essential during embryonic vessel assembly and maturation, and functions as a key regulator of adult vascular homeostasis. The structural characteristics and the spatio-temporal regulation of the expression of receptors and ligands ..
- Complement: a key system for immune surveillance and homeostasisDaniel Ricklin
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
Nat Immunol 11:785-97. 2010..microbes, orchestrating immune responses and sending 'danger' signals, complement contributes substantially to homeostasis, but it can also take action against healthy cells if not properly controlled...
- Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsyGilles Huberfeld
INSERM U739, Faculté de Médecine Pitié Salpêtrière, Universite Pierre et Marie Curie Paris 6, IFR70, CHU Pitie Salpetriere, 75013 Paris, France
J Neurosci 27:9866-73. 2007Changes in chloride (Cl-) homeostasis may be involved in the generation of some epileptic activities...
- The mitochondrial UPR - protecting organelle protein homeostasisCole M Haynes
Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 390, New York, NY 10065, USA
J Cell Sci 123:3849-55. 2010..Here, we review the current knowledge of this mitochondrial unfolded protein response (UPR(mt)), compare it with the better understood UPR of the endoplasmic reticulum and highlight its potential impact on development and disease...
- Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasisMaria M Mihaylova
Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
Cell 145:607-21. 2011..Finally, suppression of class IIa HDACs in mouse models of type 2 diabetes ameliorates hyperglycemia, suggesting that inhibitors of class I/II HDACs may be potential therapeutics for metabolic syndrome...
- The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasisMichael A Cowley
The Vollum Institute, Oregon Health and Science University, Portland, OR 97201, USA
Neuron 37:649-61. 2003..We propose that at these sites, release of ghrelin may stimulate the release of orexigenic peptides and neurotransmitters, thus representing a novel regulatory circuit controlling energy homeostasis.
- Nutrient sensing and inflammation in metabolic diseasesGokhan S Hotamisligil
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Nat Rev Immunol 8:923-34. 2008..of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival...
- Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivoK S Schluns
Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
Nat Immunol 1:426-32. 2000..We show that interleukin-7 (IL-7) plays multiple roles in regulating homeostasis of CD8+ T cells...
- AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolismBarbara B Kahn
Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
Cell Metab 1:15-25. 2005..leptin, adiponectin, and possibly resistin) in regulating food intake, body weight, and glucose and lipid homeostasis. AMPK is regulated by upstream kinases of which the tumor suppressor, LKB1, is the first to be identified...
- Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasisC E Outten
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
Science 292:2488-92. 2001..Thus, cells exert tight control over cytosolic metal concentrations, even for relatively low-toxicity metals such as zinc...
- Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animalsDavid Patsouris
Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, California, USA
Cell Metab 8:301-9. 2008..Together, these results indicate that these CD11c+ cells are a potential therapeutic target for treatment of obesity-related insulin resistance and type II diabetes...
- Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgutHuaqi Jiang
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Cell 137:1343-55. 2009..Gut homeostasis is maintained by intestinal stem cells (ISCs) that divide to replenish the intestinal epithelium, but little is ..
- Reactive oxygen species as signals that modulate plant stress responses and programmed cell deathTsanko S Gechev
Institute of Plant Sciences, ETH Zurich, Switzerland
Bioessays 28:1091-101. 2006....
- Origin and physiological roles of inflammationRuslan Medzhitov
Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, TAC S 669, 300 Cedar Street, New Haven, Connecticut 06510, USA
Nature 454:428-35. 2008..Para-inflammation is probably responsible for the chronic inflammatory conditions that are associated with modern human diseases...
- Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipaseGuenter Haemmerle
Institute of Molecular Biosciences, University of Graz, Austria
Science 312:734-7. 2006..These results indicate that ATGL is rate limiting in the catabolism of cellular fat depots and plays an important role in energy homeostasis.
- Use and abuse of HOMA modelingTara M Wallace
Oxford Centre for Diabetes, Endocrinology and Metabolism, The Churchill Hospital, Old Road, Oxford OX3 7LJ, U K
Diabetes Care 27:1487-95. 2004..However, as with all models, the primary input data need to be robust, and the data need to be interpreted carefully...
- Network motifs: theory and experimental approachesUri Alon
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
Nat Rev Genet 8:450-61. 2007..Here I review network motifs and their functions, with an emphasis on experimental studies. Network motifs in other biological networks are also mentioned, including signalling and neuronal networks...
- The role of estrogens in control of energy balance and glucose homeostasisFranck Mauvais-Jarvis
Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Endocr Rev 34:309-38. 2013..the literature in both rodents and humans on the role of estrogens and their receptors in the control of energy homeostasis and glucose metabolism in health and metabolic diseases...
- Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retinaAnand Swaroop
Neurobiology Neurodegeneration and Repair Laboratory, Building 6 338, MSC 0610, National Eye Institute, National Institutes of Health, 6 Center Drive, Bethesda, Maryland 20892, USA
Nat Rev Neurosci 11:563-76. 2010..Elucidation of gene-regulatory networks that dictate photoreceptor genesis and homeostasis will have wider implications for understanding the development of nervous system function and for the treatment ..
- Argonaute quenching and global changes in Dicer homeostasis caused by a pathogen-encoded GW repeat proteinJacinthe Azevedo
Institut de Biologie Moleculaire des Plantes du CNRS, Universite de Strasbourg, 67084 Strasbourg Cedex, France
Genes Dev 24:904-15. 2010..The likely widespread occurrence and expected consequences of GW protein mimicry on host silencing pathways are discussed in the context of innate and adaptive immunity in plants and metazoans...
- Bile acids induce energy expenditure by promoting intracellular thyroid hormone activationMitsuhiro Watanabe
Institut de Génétique et Biologie Moléculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch, France
Nature 439:484-9. 2006..This indicates that BAs might be able to function beyond the control of BA homeostasis as general metabolic integrators...
- Triacylglycerol homeostasis: insights from yeastSepp D Kohlwein
Institute of Molecular Biosciences, University of Graz, A 8010 Graz, Austria
J Biol Chem 285:15663-7. 2010..Based on these similarities, studies performed in yeast may provide further significant mechanistic insight into the molecular basis of triacylglycerol homeostasis and its important physiological roles in healthy and diseased cells.
- Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasisThomas Braun
Max Planck Institute for Heart and Lung Research, Department for Cardiac Development and Remodelling, Benekestrasse, Bad Nauheim, Germany thomas braun mpi bn mpg de
Nat Rev Mol Cell Biol 12:349-61. 2011..It has also emerged that there is extensive post-transcriptional regulation by microRNAs in development and postnatal remodelling...
- Autocrine VEGF signaling is required for vascular homeostasisSunyoung Lee
Department of Molecular, Cellular and Developmental Biology, Jonsson Comprehensive Cancer Center and Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA
Cell 130:691-703. 2007..Here we show that in the absence of any pathological insult, autocrine VEGF is required for the homeostasis of blood vessels in the adult...
- Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptorYann M Kerdiles
Molecular Biology Section, Division of Biological Sciences, Department of Cellular and Molecular Medicine, University of California, San Diego, California 92093 0377, USA
Nat Immunol 10:176-84. 2009..These data suggest that Foxo1 regulates the homeostasis and life span of naive T cells by sensing growth factor availability and regulating homing and survival signals.
- Cortical firing and sleep homeostasisVladyslav V Vyazovskiy
Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
Neuron 63:865-78. 2009..to sleep grows with the duration of wakefulness and dissipates with time spent asleep, a process called sleep homeostasis. What are the consequences of staying awake on brain cells, and why is sleep needed? Surprisingly, we do not ..
- Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cellsAlexander Link
Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
Nat Immunol 8:1255-65. 2007..Here we report a critical function for lymph node access in T cell homeostasis and identify T zone fibroblastic reticular cells in these organs as the main source of interleukin 7...
- Involvement of OsSPX1 in phosphate homeostasis in riceChuang Wang
State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, China
Plant J 57:895-904. 2009..This suggests that OsSPX1 acts via a negative feedback loop to optimize growth under phosphate-limited conditions...
- New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes riskJosee Dupuis
Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
Nat Genet 42:105-16. 2010....
- Bmi1 is expressed in vivo in intestinal stem cellsEugenio Sangiorgi
Howard Hughes Medical Institute and Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
Nat Genet 40:915-20. 2008..Unexpectedly, the distribution of Bmi1-expressing stem cells along the length of the small intestine suggested that mammals use more than one molecularly distinguishable adult stem cell subpopulation to maintain organ homeostasis.
- Discovery metabolite profiling of the prolyl peptidasesAlan Saghatelian; Fiscal Year: 2009..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
- Novel TIRF microscopy analyzing trafficking & signaling at the cell cortexDerek Toomre; Fiscal Year: 2009..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
- Optimization of DNA Repair by Abh8Lauren Endres; Fiscal Year: 2013..If these mutations disrupt the function of key regulatory genes involved in cell growth and homeostasis, premature aging or cancer can occur...
- Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, ObesitRobert A Harris; Fiscal Year: 2012..That glucose homeostasis depends upon regulation of PDC, which in turn depends upon hormonal control of the amounts of the PDKs, was the ..
- Immune Regulation of Bone HomeostasisMERVYN NEALE WEITZMANN; Fiscal Year: 2012..through B cell OPG production, and modulated by T cell costimulation, are critical regulators of basal bone homeostasis in young mice and mitigate in part, the enhanced bone resorption associated with aging"...
- Pharmacogenetics of obesity and endocannabinergic modulation (POEM)Russell A Wilke; Fiscal Year: 2012..obesity and obesity-related metabolic disorders (changes in insulin responsiveness and derangements in lipid homeostasis) in 2209 study subjects from 507 families participating in the Take Off Pounds Sensibly (TOPS) obesity research ..
- Role of Chromogranin A in Metabolic SyndromeSushil K Mahata; Fiscal Year: 2013..CST maintains glucose homeostasis by balancing increased gluconeogenesis with increased glucose disposal and decreased glycogenolysis...
- The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intakeNILS WG LAMBRECHT; Fiscal Year: 2012..gastrointestinal hormones in response to meal stimuli play an important role in the regulation of body weight homeostasis. A complete understanding of this mechanism will improve the quality of life in our veteran patients by ..
- Effects of Evoked Resistance Training and Testosterone after Spinal Cord InjuryAshraf Gorgey; Fiscal Year: 2012..It is also unknown whether enhancing the decline anabolic homeostasis by providing testosterone (T) replacement therapy (TRT) would reverse body composition and metabolic profile ..
- Sphingolipid Metabolism in Drosophila DevelopmentJulie D Saba; Fiscal Year: 2013..propose our central hypothesis, which states that SPL plays a critical role in muscle biology, development and homeostasis. The specific aims of our proposal are, thus: 1) To define the role of SPL in muscle cell biology;2) To dissect ..
- Role of SCD1 and Dietary Methionine Restriction on Energy HomeostasisERIC PAUL PLAISANCE; Fiscal Year: 2011..of SCD1 expression by dietary MR is an essential component of the mechanism used by MR to affect energy homeostasis and limit fat deposition...
- Lung Lysyl Oxidase Regulation by Metal Ion HomeostasisWande Li; Fiscal Year: 2013..LO as a metalloenzyme is susceptible to changes in cellular metal homeostasis. Previous studies by this lab investigating the phenotype change from Cd sensitive to Cd resistant of rat lung ..
- Regulation of ER stress-induced cell deathRandal J Kaufman; Fiscal Year: 2013..PUBLIC HEALTH RELEVANCE: Diabetes is a world-wide epidemic characterized by an abnormality in glucose homeostasis that results from a failure of beta cells to produce insulin...
- METABOLIC SYNDROME AND PERIODONTITIS IN POSTMENOPAUSAL WOMENMichael J LaMonte; Fiscal Year: 2013..syndrome (Metsyn) is a condition of coexisting abnormalities in glucose, lipid, blood pressure, and body fat homeostasis, that affects more than half of U.S. adults 55 years and older...
- Med1 in Liver Metabolism, Regeneration and CancerJanardan K Reddy; Fiscal Year: 2013DESCRIPTION (provided by applicant): The liver plays a pivotal role in energy homeostasis by orchestrating biochemical pathways of carbohydrate, fat, and protein metabolism and exhibits inherent compensatory regeneration capacity to ..
- MOLECULAR BASIS OF INSULIN RESISTANCEMaureen J Charron; Fiscal Year: 2010..of hepatic substrate utilization and insulin sensitivity is crucial for maintenance of whole body glucose homeostasis as it integrates signals from the gut, peripheral tissue and central nervous system...
- Iron, Metabolic Regulation and Type 2 Diabetes RiskDonald A McClain; Fiscal Year: 2013..and the dysregulation that we demonstrate occurs in diabetes, should have important consequences for iron homeostasis and inflammation, both of which have been demonstrated to contribute to diabetes pathogenesis...
- Biology and Pathologies of Type V CollagenDaniel S Greenspan; Fiscal Year: 2013..mice, to determine the full range of 13(V) roles in ultrastructure, cell biology, development, metabolism, homeostasis and disease - the latter including possible heritable diseases and/or predispositions to chronic ailments in ..
- Insulin Signaling and the Heart in DiabetesEVAN DALE ABEL; Fiscal Year: 2011..Multiple mechanisms such as lipotoxicity, glucotoxicity, oxidative stress, impaired myocardial calcium homeostasis and impaired insulin signaling have been implicated...
- Retinoid Metabolism and Alcohol Induced DiseaseWilliam S Blaner; Fiscal Year: 2010..Reasons proposed in the literature to explain why retinoid homeostasis is impaired in alcoholics are: 1...
- Hydrodynamic forces modulate renal tubular functionRajeev Rohatgi; Fiscal Year: 2012..addition, salt-sensitive hypertension is associated with and linked to deficiencies in renal PGE2 synthesis and homeostasis. The physiologic and/or cellular triggers regulating PGE2 production in the distal nephron that maintain ..
- Regulation of epithelial cell homeostasis by actin microfilamentsSeema Khurana; Fiscal Year: 2010..relevance of full-length and cleaved villin fragments respectively, in the maintenance of gastrointestinal homeostasis;(ii) to characterize the interaction of villin with ATP synthase 2- subunit to examine the relevance of this ..
- Role of the Mammalian Siderophore in Cellular Iron Metabolism and ErythropoiesisLaxminarayana R Devireddy; Fiscal Year: 2012..of cellular iron levels, suggesting a new and unanticipated role for the mammalian siderophore in cellular iron homeostasis. We will probe the role of IRE-IRP network in the regulation of the mammalian siderophore levels and in ..
- INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEMJERROLD MICHAEL OLEFSKY; Fiscal Year: 2013..the effects of FOX01 repression of PPAR3 on overall in vivo insulin sensitivity TZD-responsiveness and glucose homeostasis. Finally, CD11c+ macrophage represents the majority of the macrophages recruited into obese adipose tissues...
- Role for Na,K-ATPase in Nucleoplasmic Calcium HomeostasisCraig Gatto; Fiscal Year: 2010..Now recent evidence has emerged demonstrating that the Na/Ca exchanger plays a role in nuclear calcium homeostasis in some cells which immediately suggests that there must be a sodium concentration gradient across the nuclear ..
- Alternative Macrophage Activation Limits ImmunopathologyDEBROSKI R HERBERT; Fiscal Year: 2011..immunopathology Macrophages (MF) form a heterogeneous population of mononuclear phagocytes necessary for organ homeostasis, host defense, and immunoregulation...
- Tat and CDK9 on gene expression alterations coupled to HIV-1 Associated DementiaXavier Grana; Fiscal Year: 2010..These proteins may affect astrocyte homeostasis, which in turn will influence neuronal function or might be secreted and taken up by neurons to directly affect ..
- Steroid Responsive Mechanisms in the EarDENNIS ROYAL TRUNE; Fiscal Year: 2012..and the mineralocorticoid receptor, thus regulating cochlear gene expression via immune suppression and ion homeostasis, respectively...
- Regulation of microRNA-375 by cyclic-AMP in pancreatic beta-cellsDAVID MATTHEW KELLER; Fiscal Year: 2010..messenger signaling cascade is a key regulator of diverse cellular process such as insulin secretion and energy homeostasis (Seino and Shibasaki, 2005)...
- The Kallikrein/Kinin-Mast Cell Interaction in Volume OverloadCHIH CHANG KEVIN WEI; Fiscal Year: 2013..We will study the effects of kallikrein inhibition on in vivo LV function, ECM homeostasis, ISF BK and chymase activity, and mast cell degranulation in response to VO in the early and chronic time ..
- Central Action of Brain-Derived Neurotrophic Factor in Male and Female RatsHaifei Shi; Fiscal Year: 2010..to the loss of BDNF signaling and thus a functional BDNF system is more crucial in the regulation of energy homeostasis in females...
- Bisphosphonates in the treatment of chronic kidney disease-mineral bone diseaseSharon M Moe; Fiscal Year: 2013..rats with zoledronic acid at early and late time points and determine the effect of serum measures of mineral homeostasis, bone turnover, architecture and biomechanics, and arterial calcification, aorta compliance and left ..
- Arcuate nucleus glutamatergic neurons modulate energy homeostasisAnthony N van den Pol; Fiscal Year: 2013..axonal information from other regions of the brain that also play important roles in CNS regulation of energy homeostasis, and sending out efferent information that regulates food intake and utilization...
- Notch and Regulators of Notch Signaling Impact Both Glucose and Lipid MetabolismUTPAL BHAGIRATH PAJVANI; Fiscal Year: 2013..that genetic inhibition of hepatic Notch action demonstrated beneficial effects in both glucose and lipid homeostasis. These effects were recapitulated by pharmacologic inhibitors of Notch action, which were able to markedly ..
- Osteocalcin and Metabolic Risk Factors. The Framingham StudyYi Hsiang Hsu; Fiscal Year: 2011..for how OC interacting with adipocytes, pancreatic 2 cells and other molecules functionally involved in glucose homeostasis are still unclear...
- Regulation of Bile Acid Synthesis by Nuclear ReceptorsJohn Y L Chiang; Fiscal Year: 2013..Alteration of bile acid synthesis impairs metabolic homeostasis leading to diabetes, obesity, and cardiovascular diseases...
- Iron in the pathogenesis of Friedreich's ataxiaARNULF HANS WERNER KOEPPEN; Fiscal Year: 2013..Its putative normal function is the biogenesis of iron- sulfur (Fe-S) clusters conveying iron homeostasis to the entire cell...
- Biology of IGFs in BoneThomas L Clemens; Fiscal Year: 2013..studies will test the novel hypothesis that the osteoblast plays a critical role in the maintenance of glucose homeostasis. Specific Aim 2: Define the mechanisms through which OC influences pancreatic ss-cell function Preliminary ..
- Sirtuin/FOXO Signaling in the Regulation of Bone MassStavroula Kousteni; Fiscal Year: 2012DESCRIPTION (provided by applicant): Bone homeostasis in the adult or aging skeleton, is perturbed by mechanisms that involve decreased defense against oxidative stress and/or increased production of Reactive Oxygen Species (ROS)...
- ER stress: role in myocyte apoptosis and myocardial remodelingKrishna Singh; Fiscal Year: 2013..ER stress induced by accumulation of misfolded proteins and alterations in calcium homeostasis can trigger apoptosis...
- Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal AxisRobert J Handa; Fiscal Year: 2013..Activation of the HPA axis is a basic response of animals to environmental perturbations that threaten homeostasis. These responses are regulated by neurons residing in the paraventricular nucleus of the hypothalamus (PVN) ..
- PATHOPHYSIOLOGY OF THE ENDOTHELIUMFrancis W Luscinskas; Fiscal Year: 2013..The vascular endothelium plays an active and vital role in regulating inflammatory responses and in maintaining homeostasis of the innate and adaptive immune systems...
- Role of Mitochondria in the Regulation of Iron metabolism by AlcoholDUYGU DEE DEE HARRISON-FINDIK; Fiscal Year: 2012..Hepcidin is a circulatory peptide synthesized in the liver. It plays a central role in iron homeostasis by regulating both intestinal and reticulo-endothelial iron transport...
- Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol HomeostasisKamal D Mehta; Fiscal Year: 2010..regarding the role and regulation of adipose LDL receptors and its relationship to whole body cholesterol homeostasis. Also, our knowledge of the signaling pathway controlling adipose endocrine and lipo-metabolic functions ..
- Role of Peroxidasin in Glomerular Matrix HomeostasisGautam Bhave; Fiscal Year: 2013..Ultimately, Dr. Bhave hopes to translate his seminal biochemical discovery into an independent line of investigation examining the role of peroxidasin in matrix remodeling and expansion in renal disease. ..
- An Aldosterone-Endothelin Feedback Mechanism on Sodium HomeostasisCharles S Wingo; Fiscal Year: 2012..results of these studies will provide valuable insight into how aldosterone and ET-1 interact to modulate Na homeostasis. Importantly, these studies will lend understanding into a novel signaling pathway that may explain the role of ..
- Ceramide Metabolism and Photoreceptor HomeostasisUsha R Acharya; Fiscal Year: 2013..the focus of this project is to continue to understand how sphingolipid metabolism regulates photoreceptor homeostasis. The specific aims of the project are: (1) To obtain further insight into ceramide mediated disruption of ..
- Regulation of Hepatic SphK2 by Bile Acids: Effects on Lipid MetabolismHUIPING ROSE ZHOU; Fiscal Year: 2013DESCRIPTION (provided by applicant): Bile acids are crucial for lipid homeostasis in the liver. During the last decade, researchers have discovered that bile acids not only act as detergents, but also as important signaling molecules...
- Effects of Standardized Aerobic Exercise-Training on Neurocognitive and NeurodegeThomas O Obisesan; Fiscal Year: 2010..we will examine the effects of aerobic exercise-training on neurocognitive function, and on cerebral glucose homeostasis. It is yet to be determined whether AAs with mild AD can be recruited into such a study, nor has the ..
- Lipid Droplet MetabolismFredric B Kraemer; Fiscal Year: 2013..This hypothesis will be tested through the exploration of the function of specific LD-associated proteins on LD homeostasis and cholesterol transport for steroidogenesis...
- Integrated signaling of eicosanoids in HSC formation and regenerationTrista E North; Fiscal Year: 2013..The eicosanoid prostaglandin E2 (PGE2) can regulate embryonic HSC formation and adult homeostasis across vertebrate species...
- Role of stearoyl CoA desaturase-1 in TLR5 KO mice colitis and metabolic syndromeMatam Vijay Kumar; Fiscal Year: 2013..epithelial cels, develop spontaneous colitis because of an inability to maintain intestinal bacterial homeostasis. Further, upon rederivation of TLR5KO mice via embryonic transfer, ocurence of spontaneous colitis was ..
- Sex Hormones in Postmenopausal Women in the Diabetes Prevention ProgramCatherine Kim; Fiscal Year: 2012..hormone only, lack of significant glucose changes, lack of measurement of potential confounders such as insulin homeostasis, or examination only in Caucasians of European ancestry...
- Targeting AP-1 proteins in COPDSEKHAR M POTHIREDDY; Fiscal Year: 2010..lung cell proliferation and apoptosis, as well as extracellular matrix degradation, can alter lung cell homeostasis and architecture, leading to the development and progression of COPD...
- Aldosterone Action In The Brain, Hypertension and InflammationELISE PEERY GOMEZ-SANCHEZ; Fiscal Year: 2012..parts of the normal human and rat brain, only a few of which are involved in hemodynamic, fluid and electrolyte homeostasis and neurally modulated inflammatory processes...
- OLIGOCLONAL T CELL EXPANSION AND RHEUMATOID ARTHRITISCornelia M Weyand; Fiscal Year: 2012..The current application will investigate this defect in T cell homeostasis and builds on our preliminary data, demonstrating a striking impairment in the survival of na[unreadable]ve CD4 ..
- Stem Cell Homing for Treatment of Female Pelvic Floor DisordersMargot S Damaser; Fiscal Year: 2013..Lysyl oxidase-like 1 (LOXL1) is a protein essential for elastin remodeling and homeostasis. Unlike in normal mice, vaginal delivery in LOXL1 knockout (KO) mice results in POP and SUI, making it an ideal ..
- Regulation of K-Ras by a Farnesyl-electrostatic SwitchMARK REID PHILIPS; Fiscal Year: 2013..We will ascertain if phospho-K-Ras alters mitochondrial calcium homeostasis. We will determine if IP3R, calpain and autophagy are required for phospho-K-Ras mediated cell death...
- Neural Functioning of Feeding Centers in Obese YouthROBERT STANLEY SHERWIN; Fiscal Year: 2013..in conjunction with high circulating insulin levels, might also display abnormal neuronal activity in certain regions of the brain, some of which are known to be key regulators of energy homeostasis and food seeking behavior.
- Role of MicroRNA mi R-33 in Controlling Cholesterol/Lipid HomeostasisAnders M Naar; Fiscal Year: 2010..transcription factors have been identified as key regulators of genes involved in both cholesterol and lipid homeostasis. Because of the prominence of aberrant cholesterol and lipid homeostasis in the metabolic dysregulation ..
- The mechanisms by which alcohol and HIV render the lung susceptible to injuryDAVID MARSHALL GUIDOT; Fiscal Year: 2013..clinical and experimental findings suggest that alcohol abuse and HIV-1 infection both interfere with zinc homeostasis and activation of anti-oxidant defenses within the airway and thereby render the lung susceptible to injury...
- Runx Proteins and Sex Steroid Signaling in BoneBaruch Frenkel; Fiscal Year: 2009..Runx2 is a master osteoblast transcription factor playing pivotal roles in skeletal development and homeostasis. In humans, Runx2 haplotypes contribute to variations in bone mass...
- The Effects of Hyper and Hypocapnia on Phonatory Laryngeal ResistanceAmanda I Gillespie; Fiscal Year: 2012..by applicant): The larynx has a challenging dual role in the simultaneous regulation of breathing for blood-gas homeostasis and voice production for communication...
- Beauveriolide-Derived Cyclodepsipeptides as a New Class of Anti-Alzheimer's DrugsPaul Wentworth; Fiscal Year: 2010..It has been shown definitively that the generation and clearance of A2 in the CNS is regulated by cholesterol homeostasis. Compounds that perturb cellular free cholesterol homeostasis such as acyl-coenzyme A: cholesterol ..
- Neuroendocrine Response to Gastric Bypass in Nonhuman PrimatesRandy J Seeley; Fiscal Year: 2010..of physiological systems, including the regulation of ingestive behavior, energy expenditure and glucose homeostasis. In contrast to restrictive diets, surgery-induced weight loss is associated with decreased hunger and hedonic ..
- Understanding the role of bile as a mechanism for improved glucose homeostasis foAPRIL DAWN STRADER; Fiscal Year: 2010..Interposition has been shown to improve glucose homeostasis in rat models of diabetes. Importantly, ileal interposition improves type-II diabetes in humans...
- Walnuts vs. Walnut-Oil, Glucose Homeostasis, PCOSSidika Kasim Karakas; Fiscal Year: 2007..by applicant): Our overall aim is to investigate the effects of dietary fatty acid composition on glucose homeostasis in women with polycystic ovary syndrome (PCOS)...
- METABOLIC HOMEOSTASIS IN LIVER REGENERATIONLINDA GREENBAUM; Fiscal Year: 1999..Despite the loss of two-thirds of the liver mass, metabolic and synthetic homeostasis is maintained...
- Redox Biology in COPDYvonne Janssen Heininger; Fiscal Year: 2009..Yet, the concept that oxidants are molecules with regulatory functions important in normal cell and tissue homeostasis has also emerged...
- Amyloid Beta-Protein: ApoE and Cholesterol HomeostasisWELLINGTON WOOD; Fiscal Year: 2009This application focuses on mechanisms of amyloid beta-protein perturbation of cholesterol and apoE homeostasis within astrocytes and resulting consequences on neuronal function...
- Cholesterol Homeostasis in Framingham Offspring StudyAlice Lichtenstein; Fiscal Year: 2006The objective of this application is to investigate the predictive value of using measures of cholesterol homeostasis to identify individuals at high risk of developing cardiovascular disease (CVD) relative to established risk factors...
- Human Zinc Transporter Zip 13 and Cellular Zinc HomeostasisJoel Walker; Fiscal Year: 2007..One mechanism to regulate cellular zinc homeostasis involves the Zrt-, Irt-like, Protein (ZIP) family of zinc transporters which function to import zinc into the ..
- HYPOTHALAMIC CONTROL OF FEEDING AND METABOLISMROGER CONE; Fiscal Year: 2003..individuals to lose weight is the multifactorial neuroendocrine processes that function to maintain energy homeostasis. Decreased caloric intake results in a decrease in basal metabolic rate, and even decreased energy requirements ..