body patterning

Summary

Summary: The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.

Top Publications

  1. ncbi Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    C Chiang
    Laboratory of Mammalian Genes and Development, National Institute of Health, Bethesda, Maryland 20892, USA
    Nature 383:407-13. 1996
  2. ncbi Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles
    Pamela F Colosimo
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Science 307:1928-33. 2005
  3. ncbi A segmentation clock with two-segment periodicity in insects
    Andres F Sarrazin
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Nikolaou Plastira 100, GR 70013 Heraklio, Crete, Greece
    Science 336:338-41. 2012
  4. ncbi Modulating Hox gene functions during animal body patterning
    Joseph C Pearson
    Section in Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093, USA
    Nat Rev Genet 6:893-904. 2005
  5. ncbi The PLETHORA genes mediate patterning of the Arabidopsis root stem cell niche
    Mitsuhiro Aida
    Department of Molecular Cell Biology, Utrecht University, Padualaan 8, 3514CH Utrecht, The Netherlands
    Cell 119:109-20. 2004
  6. pmc Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2
    Satoko Yoshiba
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Suita, 565 0871 Osaka, Japan
    Science 338:226-31. 2012
  7. pmc Shadow enhancers as a source of evolutionary novelty
    Joung Woo Hong
    Department of Molecular and Cell Biology, Division of Genetics, Genomics, and Development, Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA
    Science 321:1314. 2008
  8. pmc Principles of planar polarity in animal development
    Lisa V Goodrich
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Development 138:1877-92. 2011
  9. ncbi The graded response to Sonic Hedgehog depends on cilia architecture
    Tamara Caspary
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Dev Cell 12:767-78. 2007
  10. ncbi Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
    Brian D Harfe
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Cell 118:517-28. 2004

Detail Information

Publications363 found, 100 shown here

  1. ncbi Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    C Chiang
    Laboratory of Mammalian Genes and Development, National Institute of Health, Bethesda, Maryland 20892, USA
    Nature 383:407-13. 1996
    ..Defects in all tissues extend beyond the normal sites of Shh transcription, confirming the proposed role of Shh proteins as an extracellular signal required for the tissue-organizing properties of several vertebrate patterning centres...
  2. ncbi Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles
    Pamela F Colosimo
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Science 307:1928-33. 2005
    ....
  3. ncbi A segmentation clock with two-segment periodicity in insects
    Andres F Sarrazin
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Nikolaou Plastira 100, GR 70013 Heraklio, Crete, Greece
    Science 336:338-41. 2012
    ..Our results show that molecular oscillators represent a common feature of segmentation in divergent animals and help reconcile the contrasting paradigms of insect and vertebrate segmentation...
  4. ncbi Modulating Hox gene functions during animal body patterning
    Joseph C Pearson
    Section in Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093, USA
    Nat Rev Genet 6:893-904. 2005
    ..Finally, the recent discovery of microRNA genes within the Hox gene clusters indicates yet another level of control by Hox genes in development and evolution...
  5. ncbi The PLETHORA genes mediate patterning of the Arabidopsis root stem cell niche
    Mitsuhiro Aida
    Department of Molecular Cell Biology, Utrecht University, Padualaan 8, 3514CH Utrecht, The Netherlands
    Cell 119:109-20. 2004
    ..Thus, the PLT genes are key effectors for establishment of the stem cell niche during embryonic pattern formation...
  6. pmc Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2
    Satoko Yoshiba
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Suita, 565 0871 Osaka, Japan
    Science 338:226-31. 2012
    ..Our results thus suggest that nodal flow is sensed in a manner dependent on Pkd2 by the cilia of crown cells located at the edge of the node...
  7. pmc Shadow enhancers as a source of evolutionary novelty
    Joung Woo Hong
    Department of Molecular and Cell Biology, Division of Genetics, Genomics, and Development, Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA
    Science 321:1314. 2008
  8. pmc Principles of planar polarity in animal development
    Lisa V Goodrich
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Development 138:1877-92. 2011
    ..Here, we review the molecular mechanisms and cellular consequences of planar polarisation in diverse contexts, seeking to identify the common principles across the animal kingdom...
  9. ncbi The graded response to Sonic Hedgehog depends on cilia architecture
    Tamara Caspary
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Dev Cell 12:767-78. 2007
    ..Thus, normal structure of the ciliary axoneme is required for the cell to translate different levels of Shh ligand into differential regulation of the Gli transcription factors that implement Hedgehog signals...
  10. ncbi Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
    Brian D Harfe
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Cell 118:517-28. 2004
    ..Genetic studies of the effects of limiting accessibility of Shh within the limb support this model, in which the effect of the Shh morphogen is dictated by a temporal as well as a spatial gradient...
  11. ncbi Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
    M van de Wetering
    Department of Immunology, University Hospital, Utrecht, The Netherlands
    Cell 88:789-99. 1997
    ..Epistasis analysis positions dTCF downstream of armadillo. The Armadillo-dTCF complex mediates Wingless signaling as a bipartite transcription factor...
  12. ncbi Far from solved: a perspective on what we know about early mechanisms of left-right asymmetry
    Laura N Vandenberg
    Biology Department, and Tufts Center for Regenerative and Developmental Biology, Tufts University, Medford, Massachusetts 02155, USA
    Dev Dyn 239:3131-46. 2010
    ..Many questions about embryonic left-right asymmetry remain open, offering fascinating avenues for further research in cell, developmental, and evolutionary biology...
  13. ncbi Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis
    F Reifers
    Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
    Development 125:2381-95. 1998
    ..Fgf8 is therefore required in development of several important signaling centers in the zebrafish embryo, but may be redundant or dispensable for others...
  14. ncbi Requirement for Wnt3 in vertebrate axis formation
    P Liu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 22:361-5. 1999
    ..These studies provide genetic proof for the requirement of Wnt3 in primary axis formation in the mouse...
  15. pmc Multiple forces contribute to cell sheet morphogenesis for dorsal closure in Drosophila
    D P Kiehart
    Department of Cell Biology, Cell and Molecular Biology Program, University Program in Genetics and the Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, North Carolina 27710 3709, USA
    J Cell Biol 149:471-90. 2000
    ..Moreover, our observations demonstrate that wound healing in this insect epidermal system parallel wound healing in vertebrate tissues in situ and vertebrate cells in culture (for review see Kiehart, D.P. 1999. Curr. Biol. 9:R602-R605)...
  16. pmc The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning
    Man Mohan
    Institute for Genetics, Justus Liebig University Giessen, Heinrich Buff Ring, Giessen, Germany
    EMBO J 26:4203-14. 2007
    ..A short pulse of dCTCF expression during larval development rescues the dCTCF loss of function phenotype. Overall, we demonstrate the importance of dCTCF in fly development and in the regulation of abdominal segmentation...
  17. pmc Hox specificity unique roles for cofactors and collaborators
    Richard S Mann
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA
    Curr Top Dev Biol 88:63-101. 2009
    ....
  18. ncbi Wnt signaling and the polarity of the primary body axis
    Christian P Petersen
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 139:1056-68. 2009
    ..The use of posterior Wnt signaling and anterior Wnt inhibition might be a unifying principle of body plan development in most animals...
  19. pmc Hox genes and regional patterning of the vertebrate body plan
    Moises Mallo
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Dev Biol 344:7-15. 2010
    ..The control of these functions must have been intimately linked to the shaping of the body plan during evolution...
  20. ncbi Boundary formation and maintenance in tissue development
    Christian Dahmann
    Biotechnology Center, BIOTEC and Center for Regenerative Therapies CRTD, Dresden University of Technology, Tatzberg 47 49, 01307 Dresden, Germany
    Nat Rev Genet 12:43-55. 2011
    ..In particular, in the past couple of years the role of forces acting in epithelial tissues to maintain boundaries has emerged as a new principle in understanding how early pattern is made into permanent anatomy...
  21. ncbi Reaction-diffusion model as a framework for understanding biological pattern formation
    Shigeru Kondo
    Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, 565 0871, Japan
    Science 329:1616-20. 2010
    ..In this review, we describe the essence of this theory for experimental biologists unfamiliar with the model, using examples from experimental studies in which the RD model is effectively incorporated...
  22. pmc Multiple enhancers ensure precision of gap gene-expression patterns in the Drosophila embryo
    Michael W Perry
    Department of Integrative Biology, Biophysics Graduate Group, University of California, Berkeley, CA 94720 3200, USA
    Proc Natl Acad Sci U S A 108:13570-5. 2011
    ..We present different models for "enhancer synergy," whereby two enhancers with overlapping activities produce authentic patterns of gene expression...
  23. pmc Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis
    Amitabha Bandyopadhyay
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 2:e216. 2006
    ..In contrast, we find that the loss of both BMP2 and BMP4 results in a severe impairment of osteogenesis...
  24. pmc Dorsal-ventral patterning and neural induction in Xenopus embryos
    Edward M De Robertis
    Howard Hughes Medical Institute, Department of Biological Chemistry, University of California Los Angeles, Los Angeles, CA 90095 1662, USA
    Annu Rev Cell Dev Biol 20:285-308. 2004
    ..Many of the molecular players that regulate D-V patterning via regulation of BMP signaling have been conserved between Drosophila and the vertebrates...
  25. ncbi Patterning embryos with oscillations: structure, function and dynamics of the vertebrate segmentation clock
    Andrew C Oates
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden, Germany
    Development 139:625-39. 2012
    ..The ongoing development of real-time clock reporters and mathematical models promise novel insight into the dynamic behavior of the clock...
  26. pmc FGF signalling during embryo development regulates cilia length in diverse epithelia
    Judith M Neugebauer
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112 5330, USA
    Nature 458:651-4. 2009
    ..We propose that a subset of developmental defects and diseases ascribed to FGF signalling are due in part to loss of cilia function...
  27. pmc Early steps in the development of the forebrain
    Stephen W Wilson
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Dev Cell 6:167-81. 2004
    ..Here, we discuss early events in forebrain development--those that lead to the establishment of the anterior neural plate and the regional subdivision of this territory into the different domains of the prospective forebrain...
  28. ncbi Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation
    C Meno
    Division of Molecular Biology, Osaka University, Japan
    Mol Cell 4:287-98. 1999
    ..Expression of antivin is dependent on Nodal signaling, revealing a feedback loop wherein Nodal signals induce their antagonists Lefty2 and Antivin to restrict Nodal signaling during gastrulation...
  29. pmc Gene regulatory networks for development
    Michael Levine
    Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 102:4936-42. 2005
    ..Here, we survey salient points of these networks, by using as reference those governing specification of the endomesoderm in sea urchin embryos and dorsal-ventral patterning in the Drosophila embryo...
  30. ncbi Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo
    Sebastian J Arnold
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    Nat Rev Mol Cell Biol 10:91-103. 2009
    ..Relevant studies in lower vertebrates indicate the conservation and divergence of regulatory mechanisms for cell lineage allocation and axis patterning...
  31. ncbi Sonic hedgehog regulates the growth and patterning of the cerebellum
    N Dahmane
    The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA
    Development 126:3089-100. 1999
    ..In addition, they provide a cellular context for medulloblastomas, childhood cancers of the cerebellum...
  32. pmc A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
    Steven A Vokes
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 22:2651-63. 2008
    ..These studies provide the first comprehensive characterization of the transcriptional output of a Shh-patterning process in the mammalian embryo and a framework for elaborating regulatory networks in the developing limb...
  33. pmc Candidate gene screen in the red flour beetle Tribolium reveals six3 as ancient regulator of anterior median head and central complex development
    Nico Posnien
    Center for Molecular Physiology of the Brain CMPB, Göttingen Center of Molecular Biology, Caspari Haus, Georg August University Gottingen, Gottingen, Germany
    PLoS Genet 7:e1002416. 2011
    ..These functions are very likely conserved among bilaterians since vertebrate six3 is required for neuroendocrine and median brain development with certain mutations leading to holoprosencephaly...
  34. ncbi A genetic approach to the transcriptional regulation of Hox gene clusters
    Patrick Tschopp
    National Center of Competence in Research, Frontiers in Genetics, Department of Genetics and Evolution, University of Geneva, 1211 Geneva 4, Switzerland
    Annu Rev Genet 45:145-66. 2011
    ..We discuss the high heuristic value of this system in our general understanding of how changes in transcriptional regulation can diversify gene function and thereby fuel morphological evolution...
  35. ncbi Zebrafish pigmentation mutations and the processes of neural crest development
    R N Kelsh
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:369-89. 1996
    ..In combination with the embryological advantages of zebrafish, these mutations should permit cellular and molecular dissection of many aspects of neural crest development...
  36. ncbi Patterned gene expression directs bipolar planar polarity in Drosophila
    Jennifer A Zallen
    Department of Molecular Biology, Princeton University, Lewis Thomas Lab, Washington Road, Princeton, NJ 08544, USA
    Dev Cell 6:343-55. 2004
    ..These results indicate that spatial patterns of gene expression coordinate planar polarity across a multicellular population through the localized distribution of proteins required for cell movement...
  37. ncbi Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network
    Eric Dessaud
    Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    Development 135:2489-503. 2008
    ..We discuss recent advances in our understanding of these events and highlight unresolved questions...
  38. pmc A system of repressor gradients spatially organizes the boundaries of Bicoid-dependent target genes
    Hongtao Chen
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Cell 149:618-29. 2012
    ..These results put conceptual limits on the Bcd morphogen hypothesis and demonstrate how the Bcd gradient functions within the gene network that patterns the embryo...
  39. ncbi Morphogen gradients: from generation to interpretation
    Katherine W Rogers
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Cell Dev Biol 27:377-407. 2011
    ..In this review, we describe the morphogen concept and discuss the mechanisms that underlie the generation, modulation, and interpretation of morphogen gradients...
  40. ncbi Maternal and zygotic control of zebrafish dorsoventral axial patterning
    Yvette G Langdon
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Genet 45:357-77. 2011
    ....
  41. pmc The evolution of nervous system patterning: insights from sea urchin development
    Lynne M Angerer
    National Institute for Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Development 138:3613-23. 2011
    ..Here, we review these conserved nervous system patterning signals and consider how the relationships between them might have changed during deuterostome evolution...
  42. ncbi Directed differentiation of embryonic stem cells into motor neurons
    Hynek Wichterle
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Cell 110:385-97. 2002
    ..Thus, inductive signals involved in normal pathways of neurogenesis can direct ES cells to form specific classes of CNS neurons...
  43. ncbi Hox genes and segmentation of the hindbrain and axial skeleton
    Tara Alexander
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Annu Rev Cell Dev Biol 25:431-56. 2009
    ..In this review, we compare and contrast the signaling inputs and transcriptional mechanisms by which Hox gene regulatory networks are established during segmentation in these two different systems...
  44. ncbi Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos
    Qinghua Tao
    Division of Developmental Biology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Cell 120:857-71. 2005
    ..Second, we show that activation requires the glycosyl transferase X.EXT1. Third, we find that the EGF-CFC protein, FRL1, is also essential and interacts with Wnt11 to activate canonical Wnt signaling...
  45. ncbi Fgf8 controls regional identity in the developing thalamus
    Ayane Kataoka
    RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Development 135:2873-81. 2008
    ..These findings suggest conserved roles of FGF signaling in patterning along the A/P axis in CNS, and reveal mechanisms of nucleogenesis in the developing thalamus...
  46. pmc The gap gene network
    Johannes Jaeger
    Centre de Regulacio Genomica, Universtitat Pompeu Fabra, Barcelona, Spain
    Cell Mol Life Sci 68:243-74. 2011
    ..My survey concludes that studies of the gap gene system continue to reveal interesting and important new insights into the role of gene regulatory networks in development and evolution...
  47. pmc Planar cell polarity signaling: from fly development to human disease
    Matias Simons
    Mount Sinai School of Medicine, Department of Developmental and Regenerative Biology, New York, NY 10029, USA
    Annu Rev Genet 42:517-40. 2008
    ..This review discusses new developments in the molecular understanding of PCP establishment in Drosophila and vertebrates; these developments are integrated with new evidence that links PCP signaling to human disease...
  48. ncbi Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning
    Lijiang Ma
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
    Development 132:5601-11. 2005
    ..Our data indicate that Bmp2 has a crucial role in coordinating multiple aspects of AV canal morphogenesis...
  49. pmc Signaling gradients during paraxial mesoderm development
    Alexander Aulehla
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Cold Spring Harb Perspect Biol 2:a000869. 2010
    ..Finally, links between the process of axial specification of vertebral segments and Hox gene expression are discussed...
  50. ncbi Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation
    Eric van den Akker
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Development 129:2181-93. 2002
    ..The function of Cdx genes in morphogenetic processes during gastrulation and tail bud extension, and their relationship with the Hox genes are discussed in the light of available data in Amphioxus, C. elegans, Drosophila and mice...
  51. ncbi Members of the YABBY gene family specify abaxial cell fate in Arabidopsis
    K R Siegfried
    Section of Plant Biology, University of California Davis, Davis, CA 95616, USA
    Development 126:4117-28. 1999
    ..Furthermore, ectopic expression studies suggest that ubiquitous abaxial cell fate and maintenance of a functional apical meristem are incompatible...
  52. ncbi Molecular genetics of axis formation in zebrafish
    Alexander F Schier
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016 6497, USA
    Annu Rev Genet 39:561-613. 2005
    ..Noncanonical Wnt signaling is required for the morphogenetic movements during gastrulation. We review how the coordinated interplay of these molecules determines the fate and movement of embryonic cells...
  53. ncbi Stem cells, signals and vertebrate body axis extension
    Valerie Wilson
    University of Edinburgh, Edinburgh EH9 3JQ, UK
    Development 136:1591-604. 2009
    ..We also review the location and molecular characteristics of these putative stem cells, along with their evolutionary conservation in vertebrates and the signalling mechanisms that regulate and arrest axis extension...
  54. ncbi Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2
    B G Novitch
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Neuron 31:773-89. 2001
    ..Together, these studies show that Olig2 has a critical role in integrating diverse features of motor neuron differentiation in the developing spinal cord...
  55. pmc The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophila
    Hsiao Lan Liang
    Department of Biology, New York University, 100 Washington Square East, New York, New York 10003, USA
    Nature 456:400-3. 2008
    ..Global expression profiling confirmed that Zld has an important role in the activation of the early zygotic genome and suggests that Zld may also regulate maternal RNA degradation during the maternal-to-zygotic transition...
  56. ncbi Wnt signalling required for expansion of neural crest and CNS progenitors
    M Ikeya
    Centre for Molecular and Developmental Biology, Faculty of Science, Kyoto University, Japan
    Nature 389:966-70. 1997
    ..Given the widespread expression of different Wnt genes in discrete areas of the mammalian neural tube, this may represent a general model for the action of Wnt signalling in the developing CNS...
  57. pmc Canonical Wnt signaling dynamically controls multiple stem cell fate decisions during vertebrate body formation
    Benjamin L Martin
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Dev Cell 22:223-32. 2012
    ..Our results demonstrate that dynamic local Wnt signaling cues specify germ layer contribution and mesodermal tissue type specification of multipotent stem cells throughout the formation of the early vertebrate embryonic body...
  58. ncbi Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
    B Wang
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 100:423-34. 2000
    ..The high relative abundance and potency of Gli3 repressor suggest specialization of Gli3 and its products for negative Hedgehog pathway regulation...
  59. pmc Identification and mechanism of regulation of the zebrafish dorsal determinant
    Fu I Lu
    Department of Cell Biology, Health Sciences Center, University of Virginia, Charlottesville, VA 22903, USA
    Proc Natl Acad Sci U S A 108:15876-80. 2011
    ....
  60. ncbi Gene expression profiles of transcription factors and signaling molecules in the ascidian embryo: towards a comprehensive understanding of gene networks
    Kaoru S Imai
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto, 606 8502, Japan
    Development 131:4047-58. 2004
    ....
  61. ncbi Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region
    Sandra Blaess
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 133:1799-809. 2006
    ..Thus, the precise spatial and temporal regulation of Gli2A and Gli3R by Shh is instrumental in coordinating mid/hindbrain development in three dimensions...
  62. ncbi WNTs in the vertebrate nervous system: from patterning to neuronal connectivity
    Lorenza Ciani
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
    Nat Rev Neurosci 6:351-62. 2005
    ..This knowledge provides a framework for the study of the mechanisms by which WNTs regulate diverse neuronal functions. Manipulation of the WNT pathways could provide new strategies for nerve regeneration and neuronal circuit modulation...
  63. pmc no tail integrates two modes of mesoderm induction
    Steven A Harvey
    Wellcome Trust and Cancer Research UK, Gurdon Institute and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Development 137:1127-35. 2010
    ..At later stages in development ntl is required for notochord formation, and our analysis has also led to the identification of the enhancer required for ntl expression in the developing notochord...
  64. ncbi Directional asymmetry of the zebrafish epithalamus guides dorsoventral innervation of the midbrain target
    Joshua T Gamse
    Carnegie Institution of Washington, Department of Embryology, Baltimore, MD 21218, USA
    Development 132:4869-81. 2005
    ..The results demonstrate that laterality of the dorsal forebrain influences the formation of midbrain connections and their molecular properties...
  65. ncbi Asymmetric distribution of dynamic calcium signals in the node of mouse embryo during left-right axis formation
    Daisuke Takao
    Laboratory for Spatiotemporal Regulations, National Institute for Basic Biology, Japan
    Dev Biol 376:23-30. 2013
    ..Our data support a model in which dynamic Ca(2+) signals in the node are involved in left-right patterning...
  66. ncbi Predicting expression patterns from regulatory sequence in Drosophila segmentation
    Eran Segal
    Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel
    Nature 451:535-40. 2008
    ..Our computational framework is generally applicable to most protein-DNA interaction systems...
  67. ncbi In situ activation pattern of Drosophila EGF receptor pathway during development
    L Gabay
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Science 277:1103-6. 1997
    ..This in situ approach can be used to monitor other receptor-triggered pathways in a wide range of organisms...
  68. ncbi Mutations affecting somite formation and patterning in the zebrafish, Danio rerio
    F J van Eeden
    MPI für Entwicklungsbiologie, Tubingen, Germany
    Development 123:153-64. 1996
    ....
  69. pmc A zebrafish Notum homolog specifically blocks the Wnt/β-catenin signaling pathway
    G Parker Flowers
    Northwestern University Feinberg School of Medicine, Department of Pediatrics, Children s Memorial Research Center, Children s Plaza 2300, Box 204, Chicago, IL 60614, USA
    Development 139:2416-25. 2012
    ..Notum 1a does not interact with Glypican 4, an essential component of the Wnt/planar cell polarity (PCP) pathway. Our results suggest a surprising specific role of Notum in the developing vertebrate embryo...
  70. pmc A segmentation clock operating in blastoderm and germband stages of Tribolium development
    Ezzat El-Sherif
    Genetics Program, Kansas State University, Manhattan, KS 66506, USA
    Development 139:4341-6. 2012
    ..These results pose intriguing evolutionary questions, as Drosophila and Tribolium segment their blastoderms using the same genes but different mechanisms...
  71. ncbi Quantitative dynamics and increased variability of segmentation gene expression in the Drosophila Krüppel and knirps mutants
    Svetlana Surkova
    Department of Computational Biology, Center for Advanced Studies, St Petersburg State Polytechnical University, 29 Polytehnicheskaya Street, St Petersburg 195251, Russia
    Dev Biol 376:99-112. 2013
    ..This is a surprising result in view of the role that mutual repression is thought to play in the gap gene system...
  72. ncbi wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila
    Hermann Aberle
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Neuron 33:545-58. 2002
    ..The NMJ phenotype is specifically rescued by transgenic expression of Wit only in motoneurons. Thus, Wit appears to function as a presynaptic receptor that regulates synaptic size at the Drosophila NMJ...
  73. pmc Dynamic reprogramming of chromatin accessibility during Drosophila embryo development
    Sean Thomas
    Department of Genome Sciences, University of Washington, Foege S310A, 1705 NE Pacific Street, Box 355065, Seattle, WA 98195, USA
    Genome Biol 12:R43. 2011
    ..Understanding the scope and features of chromatin dynamics during embryogenesis, and identifying regulatory elements important for directing developmental processes remain key goals of developmental biology...
  74. ncbi Tissue/planar cell polarity in vertebrates: new insights and new questions
    Yanshu Wang
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Development 134:647-58. 2007
    ..Studies in mice, frogs and zebrafish have revealed that similarities, as well as differences, exist between PCP in Drosophila and vertebrates...
  75. pmc A multi-cell, multi-scale model of vertebrate segmentation and somite formation
    Susan D Hester
    Biocomplexity Institute and Department of Physics, Indiana University Bloomington, Bloomington, Indiana, United States of America
    PLoS Comput Biol 7:e1002155. 2011
    ....
  76. ncbi Neocortex patterning by the secreted signaling molecule FGF8
    T Fukuchi-Shimogori
    Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, IL 60637, USA
    Science 294:1071-4. 2001
    ..These findings support a role for FGF signaling in specifying positional identity in the neocortex...
  77. ncbi Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors
    Rob Machold
    Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, New York 10016, USA
    Neuron 48:17-24. 2005
    ..Thus, we demonstrate that the cerebellar rhombic lip gives rise to multiple cell types within rhombomere 1...
  78. ncbi Retinoic acid coordinates somitogenesis and left-right patterning in vertebrate embryos
    Julien Vermot
    Stowers Institute for Medical Research, 1000E 50th Street, Kansas City, Missouri 64110, USA
    Nature 435:215-20. 2005
    ..Our data indicate that RA is important in buffering the lateralizing influence of the left-right machinery, thus permitting synchronization of the development of the two embryonic sides...
  79. pmc Canalization of gene expression and domain shifts in the Drosophila blastoderm by dynamical attractors
    - Manu
    Department of Applied Mathematics and Statistics, and Center for Developmental Genetics, Stony Brook University, Stony Brook, New York, United States of America
    PLoS Comput Biol 5:e1000303. 2009
    ..The result confirms the idea that attractors are important for developmental stability and shows a richer variety of dynamical attractors in developmental systems than has been previously recognized...
  80. ncbi Early eye development in vertebrates
    R L Chow
    Program in Developmental Biology, The Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Annu Rev Cell Dev Biol 17:255-96. 2001
    ..Questions about early eye development first addressed using tissue manipulations remain topical as we try to understand the molecular basis of this process...
  81. pmc Regulation of canonical Wnt signaling by Brachyury is essential for posterior mesoderm formation
    Benjamin L Martin
    Department of Biochemistry, University of Washington, Seattle, WA 98195 7350, USA
    Dev Cell 15:121-33. 2008
    ..We propose that a positive autoregulatory loop between Ntl/Bra and canonical Wnt signaling maintains the mesodermal progenitors to facilitate posterior somite development in chordates...
  82. ncbi Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo
    Julien Vermot
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 10142, 67404 Illkirch Cedex, Strasbourg, France
    Science 308:563-6. 2005
    ..These data implicate retinoic acid as an endogenous signal that maintains the bilateral synchrony of mesoderm segmentation, and therefore controls bilateral symmetry, in vertebrate embryos...
  83. pmc Noncanonical compensation of zygotic X transcription in early Drosophila melanogaster development revealed through single-embryo RNA-seq
    Susan E Lott
    Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America
    PLoS Biol 9:e1000590. 2011
    ....
  84. pmc Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongation
    Sérgio de Matos Simões
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
    Dev Cell 19:377-88. 2010
    ..These results demonstrate that Rho-kinase plays an instructive role in planar polarity by targeting Baz/Par-3 and myosin II to complementary cortical domains...
  85. ncbi Epigenetic temporal control of mouse Hox genes in vivo
    Natalia Soshnikova
    National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Science 324:1320-3. 2009
    ..Although it is recognized that this "Hox clock" serves to coordinate body patterning, the underlying mechanism remains elusive...
  86. ncbi Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon
    Steffen Scholpp
    MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, London SE1 1UL, UK
    Development 133:855-64. 2006
    ..Furthermore, acquisition of correct prethalamic and thalamic gene expression is dependent on direct Hh signalling. We conclude that proper maturation of the diencephalon requires ZLI-derived Hh signalling...
  87. ncbi Efflux-dependent auxin gradients establish the apical-basal axis of Arabidopsis
    Jiri Friml
    Zentrum für Molekularbiologie der Pflanzen, Universitat Tubingen, Auf der Morgenstelle 3, 72076 Tubingen, Germany
    Nature 426:147-53. 2003
    ..Our results indicate how the establishment of cell polarity, polar auxin efflux and local auxin response result in apical-basal axis formation of the embryo, and thus determine the axiality of the adult plant...
  88. pmc Canalization of gene expression in the Drosophila blastoderm by gap gene cross regulation
    - Manu
    Department of Applied Mathematics and Statistics, and Center for Developmental Genetics, Stony Brook University, Stony Brook, New York, United States of America
    PLoS Biol 7:e1000049. 2009
    ..More generally, we show that the complex multigenic phenomenon of canalization can be understood at a quantitative and predictive level by the application of a precise dynamical model...
  89. ncbi Hox genes and segmentation of the vertebrate hindbrain
    Stefan Tümpel
    Stowers Institute for Medical Research, Kansas City, Missouri, USA
    Curr Top Dev Biol 88:103-37. 2009
    ..The purpose of this chapter is to review what is known about the regulatory mechanisms which establish and maintain Hox gene expression and function in hindbrain development...
  90. ncbi WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism
    Stefanie Sick
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Science 314:1447-50. 2006
    ..These results confirm predictions of a WNT/DKK-specific mathematical model and provide in vivo corroboration of the reaction-diffusion mechanism for epidermal appendage formation...
  91. ncbi Hox patterning of the vertebrate axial skeleton
    Deneen M Wellik
    University of Michigan Medical Center, Department of Internal Medicine, Division of Molecular Medicine and Genetics, and Department of Cell and Developmental Biology, Ann Arbor, Michigan 48109 2200, USA
    Dev Dyn 236:2454-63. 2007
    ..This review summarizes genetic and embryologic findings regarding the role of Hox genes in establishing axial morphology and how these combined results impact our current understanding of the vertebrate Hox code...
  92. pmc Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning
    Francesca V Mariani
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, California 94158 2324, USA
    Nature 453:401-5. 2008
    ..We discuss how a two-signal model for P-D patterning can be integrated with the concept of early specification to explain the genetic data presented here...
  93. ncbi All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
    C Brian Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Dev Cell 6:103-15. 2004
    ..Therefore, in the spinal cord all Hh signaling is Gli dependent. Furthermore, a combination of Gli2 and Gli3 is required to regulate motor neuron development and spatial patterning of ventral spinal cord progenitors...
  94. ncbi A transgenic Lef1/beta-catenin-dependent reporter is expressed in spatially restricted domains throughout zebrafish development
    Richard I Dorsky
    Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Dev Biol 241:229-37. 2002
    ..We conclude that our TOP-dGFP reporter line faithfully illustrates domains of beta-catenin activity and enables the identification of responsive cell populations...
  95. ncbi On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes
    Christof Niehrs
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Development 137:845-57. 2010
    ....
  96. ncbi Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors
    M S Halfon
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Cell 103:63-74. 2000
    ..The integration of Pointed with the combinatorial effects of dTCF, Mad, Twist, and Tinman determines inductive Ras signaling specificity in muscle and heart development...
  97. pmc The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments
    Markus Bussen
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    Genes Dev 18:1209-21. 2004
    ..In summary, Tbx18 appears to act downstream of Mesp2 and Delta/Notch signaling to maintain the separation of anterior and posterior somite compartments...
  98. ncbi Hedgehog signalling in the mouse requires intraflagellar transport proteins
    Danwei Huangfu
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nature 426:83-7. 2003
    ..Our data show that IFT machinery has an essential and vertebrate-specific role in Hedgehog signal transduction...
  99. ncbi Butterfly wing pattern evolution is associated with changes in a Notch/Distal-less temporal pattern formation process
    Robert D Reed
    Department of Molecular and Cellular Biology, University of Arizona, 1007 E Lowell Street, Tucson, AZ 85721 USA
    Curr Biol 14:1159-66. 2004
    ....
  100. ncbi The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning
    Gilbert Weidinger
    Howard Hughes Medical Institute, Department of Pharmacology and Center for Developmental Biology, University of Washington School of Medicine, Box 357370, Seattle, Washington 98195, USA
    Curr Biol 15:489-500. 2005
    ..However, relatively little is known about Wnt target genes mediating these effects...
  101. ncbi Essential and opposing roles of zebrafish beta-catenins in the formation of dorsal axial structures and neurectoderm
    Gianfranco Bellipanni
    Department of Biology, University of Pennsylvania, Philadelphia, 19104, USA
    Development 133:1299-309. 2006
    ..We propose that the early, dorsal-promoting function of beta-catenin-2 is essential to counteract a later, dorsal- and neurectoderm-repressing function that is shared by both beta-catenin genes...

Research Grants64

  1. TRANSCRIPTIONAL REPRESSION BY POLYCOMB GROUP PRODUCTS
    Jeffrey A Simon; Fiscal Year: 2012
    ..For normal body patterning to occur, Hox genes must be kept silent in A-P positions where they are not normally expressed...
  2. Regulation of TGF-beta Signaling and Embryonic Development by GTPases
    Gerald H Thomsen; Fiscal Year: 2010
    ..GTPBP 1 or 2 in developing embryos with antisense oligonucleotides disrupts mesoderm differentiation, body patterning and organogenesis...
  3. Integrated Analyses of Taspase 1 (MLL Cleaving Protease)
    James J D Hsieh; Fiscal Year: 2010
    ..Initial studies on Taspasel deficient animals indicate the essential role of Taspasel in body patterning, nervous system development, and cell cycle progression...
  4. Characterization of Hox transcription factor complexes using proteomics
    Namiko Abe; Fiscal Year: 2013
    ..an evolutionarily conserved family of transcription factors first described for their function in segmental body patterning during development...
  5. Functional dissection of Drosophila TFIID
    Frank Sauer; Fiscal Year: 2009
    ..abstract_text> ..
  6. Training Program in Stem Cell and Regenerative Developmental Biology
    CHRISTOPHER VYVIAN ERIC WRIGHT; Fiscal Year: 2013
    ..Studies encompass embryogenesis (body patterning, organogenesis), organogenesis, physiological regulation, aging, reproduction, and cancer and regeneration...
  7. A comprehensive RNAi based screen for genes effecting neural degeneration in C. e
    Michael Bastiani; Fiscal Year: 2009
    ..elegans. If successful it will identify novel genes as entry points for therapies aimed at the prevention neuronal degeneration and the induction of neuronal regeneration. ..
  8. Translational repressors in Drosophila development
    Robin P Wharton; Fiscal Year: 2013
    ..Its mechanism of action is best understood during body patterning, where it is recruited by Pumilio protein to specific elements in the 3'-UTR of hunchback mRNA;the ..
  9. REGULATION AND FUNCTION OF THE DROSOPHILA GENE RUNT
    John Gergen; Fiscal Year: 1999
    ..This multidisciplinary approach should provide important insight into the role of runt in segmentation and will contribute significantly to our understanding of this basic biological process. ..
  10. Non-canonical Wnt Signals in Kidney Tubulogenesis
    Rachel Miller; Fiscal Year: 2009
    Wnt signaling pathways are essential to vertebrate axis specification, body patterning, and organogenesis...
  11. Zic3 and the Control of Body Pattern Formation
    STEPHANIE WARE; Fiscal Year: 2005
    ..Investigation of Zic3 function in body patterning will be undertaken via analyses of Zic3 null mutants and transgenic mice over expressing ZIC3 in mesoderm...
  12. CONSTRUCTION OF A NATIONAL RESOURCE FOR ZEBRAFISH
    JOHN MOSELEY; Fiscal Year: 1999
    ..The zebrafish is the newest of these model organisms. Because the basic principles of body patterning appear similarly during embryogenesis of all vertebrates, insights gained from work on embryonic zebrafish ..
  13. Development/Genetic Aspects of Congenital Heart Disease
    Jeffrey Towbin; Fiscal Year: 2005
    ..null mice will be mesoderm-specific and developmental stage-specific gene expression, and the mechanism of body patterning targeted chromosomal deletion (Df1) eliminates most of the murine homologs of the gens deleted in DGS...
  14. Left-Right Axis Determination and Cardiac Development
    ANN RAMSDELL; Fiscal Year: 2005
    ..The long-term significance of the work will be to identify genes and inductive processes that may result in congenital cardiac (and other) LR defects if affected by genetic or environmental perturbations. ..
  15. Differentiation of ES Cells into Renal Epithelia
    Gregory Dressler; Fiscal Year: 2006
    ..Since ES cells potentially represent an unlimited supply of renal progenitors, these experiments will lay the foundation for cell based therapies to improve the efficacy of ATN treatment. ..
  16. The role of cell polarity in vertebrate limb outgrowth
    Jeffery Barrow; Fiscal Year: 2007
    ..Furthermore he will examine the epistatic relationship between Fgf and Wnt/PCP signaling in regulating cell polarity. [unreadable] [unreadable] [unreadable]..
  17. LIM-HD Transcription Factors in Forebrain Patterning
    DENNIS O LEARY; Fiscal Year: 2008
    ..abstract_text> ..
  18. Control of Cell Proliferation by Runx Proteins
    JAMES COFFMAN; Fiscal Year: 2009
    ..purpuratus genome sequence, which will greatly facilitate both the cis-regulatory analysis of genes and the identification of purified proteins by mass spectrometry. ..
  19. Redox-sensitive developmental pathways and gene regulatory networks
    JAMES COFFMAN; Fiscal Year: 2009
    ..Finally, the Comparative Toxicogenomics Database (CTD) at MDIBL will be used to determine the relevance of the pathways discovered in sea urchins to human health, and to generate hypotheses that might explain specific human diseases. ..
  20. CELL MIGRATION, CHEMOATTRACTION AND THE RET/GDNF PATHWAY
    Gregory Dressler; Fiscal Year: 2002
    ..In addition to advancing our understanding of basic developmental processes, the mechnisms of migration and invasion by oncogenic RET derived tumor cells will also be illuminated. ..
  21. Cell Signaling in Developing Epithelia
    Gregory R Dressler; Fiscal Year: 2010
    ..How these interactions can be manipulated for therapeutic effects needs to be investigated and is the subject of this proposal. ..
  22. SONIC HEDGEHOG'S ROLE IN PATTERNING THE LIMB
    Clifford Tabin; Fiscal Year: 2004
    ..In these experiments the Ptc and Gli genes, which are too large for the chick viral vector system, we will be misexpressed in limbs of transgenic mice. ..
  23. REGULATION OF HEART ASYMMETRY
    Clifford Tabin; Fiscal Year: 2003
    ..As a step towards understanding how this occurs, we will screen for targets of LR signaling using a B‑lactamase reporter/gene trap strategy. ..
  24. TRAINING PROGRAM IN CELLULAR AND MOLECULAR NEUROSCIENCE
    ARTHUR LANDER; Fiscal Year: 2007
    ..Following completion of this program, trainees will be qualified for careers in Neuroscience research and/or teaching in basic science departments and medical schools, or for research careers in non-academic research laboratories. ..
  25. DEVELOPMENTAL GENETICS OF ZEBRAFISH METAMORPHOSIS
    DAVID PARICHY; Fiscal Year: 2005
    ....
  26. Combinatorial signaling in zebrafish development
    David Kimelman; Fiscal Year: 2005
    ..abstract_text> ..
  27. Apoptosis and Renewal of Neural Progenitor Cells
    Pasko Rakic; Fiscal Year: 2010
    ..These studies will enhance our understanding of neural plasticity and functional recovery after brain injury. ..
  28. GORDON RESEARCH CONFERENCE ON PROTEOGLYCANS
    ARTHUR LANDER; Fiscal Year: 2002
    ....
  29. PROTEOGLYCANS AND BRAIN DEVELOPMENT
    ARTHUR LANDER; Fiscal Year: 2004
    ..These studies should provide insights into how an important and poorly understood class of molecules regulates basic developmental processes, particularly in the nervous system. ..
  30. Cellular Learning and information Outside of the Brain
    Michael Levin; Fiscal Year: 2005
    ..The device and protocols we propose will ultimately also enable powerful large-scale pharmaceutical screens of drug and proteomic libraries to identify novel psychoactive compounds of high biomedical relevance to human beings. ..
  31. Novel Mechanism of Induction of Eye Tissue: Katp Channel Modulation
    Michael Levin; Fiscal Year: 2010
    ....
  32. Bioelectrical Controls of Morphogenesis
    Michael Levin; Fiscal Year: 2010
    ....
  33. MICROARCHITECTURE OF COGNITION
    Pasko Rakic; Fiscal Year: 2004
    ..abstract_text> ..
  34. Specific ion flows: a novel signal mediating stem cell-niche communication
    Michael Levin; Fiscal Year: 2008
    ..This information will be used to develop methods whereby regeneration of tissues, organs, and appendages may be induced in human patients following injury, aging, or tumor growth. [unreadable] [unreadable] [unreadable]..
  35. Functional Genomics in a Simple Model Metazoan
    MARK MARTINDALE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  36. VASCULOGENESIS IN THE MURINE ALLANTOIS
    KAREN DOWNS; Fiscal Year: 2002
    ..Further, results of our experiments will shed light on the mechanism of formation of the endothelial cell lineage. ..
  37. Molecular Development of the Endolymphatic Duct and Sac
    Daniel Choo; Fiscal Year: 2005
    ..Significantly, this proposal includes challenging but achievable goals that will provide important knowledge to the field of inner ear development. ..
  38. Automated Analysis of Learning and Memory for Neuro-Developmental Studies
    Michael Levin; Fiscal Year: 2010
    ..These three outcomes will result in the eventual development of novel therapeutics for brain diseases. ..
  39. REGULATED MRNA TRANSLATION IN DROSOPHILA BODY PATTERNING
    Paul M Macdonald; Fiscal Year: 2010
    ..In Drosophila, translational control and mRNA localization act coordinately in deployment of body patterning determinants at particular positions in the oocyte and embryo...
  40. Zebrafish normal table of post-embryonic development
    DAVID PARICHY; Fiscal Year: 2006
    ..This resource will greatly enable studies of post-embryonic zebrafish development and will facilitate the generation of new models for normal human development and disease states. [unreadable] [unreadable]..
  41. MOLECULAR BIOLOGY OF MORPHOGEN LOCALIZATION IN EMBRYOS
    Paul MacDonald; Fiscal Year: 2006
    ..here, localization of bicoid (bcd) mRNA in the Drosophila oocyte and embryo, is essential for embryonic body patterning. [unreadable] [unreadable] The goals of the proposal are to understand how bcd mRNA is recognized by the ..
  42. Transport and Complexity in Biological Systems
    ARTHUR LANDER; Fiscal Year: 2004
    ..abstract_text> ..
  43. Body Plan Formation in Early Mouse Embryo
    Yusuke Marikawa; Fiscal Year: 2004
    ....
  44. Computation tools for analyzing gene expression data
    Naama Barkai; Fiscal Year: 2004
    ..Kinetic microarray experiments that highlight specific features of the transcriptional network will be designed, performed and analyzed. Methods for extracting regulatory relationships from these experiments will be developed. ..
  45. EARLY EVENTS IN NEURAL AND HOMEOGENETIC INDUCTION
    Claudio Stern; Fiscal Year: 2005
    ..D. To explore the possible roles of 6 newly-identified candidate secreted factors in the early steps of neural induction and homeogenetic induction. ..
  46. Wnt Pathway Regulation in Embryos and Cells
    David Kimelman; Fiscal Year: 2009
    ..Since the Wnt pathway plays key roles in vertebrate development and oncogenesis, these studies will be important in advancing knowledge of the molecular basis of birth defects and cancer. ..
  47. Regulatory Genomics: BAC-GFP Library of Control Genes
    Eric Davidson; Fiscal Year: 2008
    ..Numerous letters from outside investigators attesting interest in this facility are included as an Appendix to this application. ..
  48. Notch Signaling in the Adult, Aging and Diseased Brain
    Pasko Rakic; Fiscal Year: 2005
    ..abstract_text> ..
  49. PRENATAL DEVELOPMENT OF THE VISUAL SYSTEM
    Pasko Rakic; Fiscal Year: 2006
    ....
  50. The Role of Ductin in Embryonic Morphogenesis
    Michael Levin; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  51. Interaction of BMP, WNT and SHH in the Vertebrate Limb
    Juan Carlos Izpisua Belmonte; Fiscal Year: 2005
    ....
  52. Re-engineering the MEGA software package
    Sudhir Kumar; Fiscal Year: 2009
    ..These core software enhancements will contribute to the longevity of MEGA for use in molecular evolution, bioinformatics, functional genomics, computational biology, and basic biomedicine applications. ..
  53. Viral Immunity in Drosophila
    Norbert Perrimon; Fiscal Year: 2007
    ..Because our insect virus system is sensitive to drugs that are used against human viruses, our studies may lead to the identification of novel antiviral compounds that may prove effective in mammalian cells. ..
  54. ACTIVITY DEPENDENT MECHANISMS OF VISUAL DEVELOPMENT
    Mriganka Sur; Fiscal Year: 2002
    ..Such approaches are crucial to understanding the complex cellular mechanisms that underlie the development and refinement of connections during pattern formation. ..
  55. Semaphorin-plexin signaling & vertebrate cell movement
    Jeremy Reiter; Fiscal Year: 2003
    ..By illuminating the role of plexin signaling in development, these studies may provide understanding into congenital disease as well as how cell movement is co-opted by pathologic processes such as tumor invasion and tumor angiogenesis. ..
  56. Cortical Plasticity: Inputs, Networks and Behavior
    Mriganka Sur; Fiscal Year: 2007
    ..abstract_text> ..
  57. Polarity and meiotic exit in the early C. elegans embryo
    Rebecca Lyczak; Fiscal Year: 2005
    ..These studies should provide insights into the mechanisms controlling the coordination of the cell cycle and polarity in the early embryo. ..
  58. Mechanisms of Nural Crest Cell Development
    Ching Pin Chang; Fiscal Year: 2010
    ..Aim #3: Define the molecular pathways affected by the absence of Pbx1. We will use standard molecular biology and embryology methods to study if Pax3 pathway is downstream of Pbx1 in cardiac development. ..
  59. Development of Sensory maps in the Mammalian neocortex
    Yasushi Nakagawa; Fiscal Year: 2010
    ..abstract_text> ..
  60. CONTROL OF GENE EXPRESSION DURING DROSOPHILA DEVELOPMENT
    Leslie Pick; Fiscal Year: 2002
    ..The fip-2 gene has been mapped to a chromosomal region rich in existing mutations. If one of these is a fip-2 mutation, a phenotypic analysis will be carried out. ..
  61. 2001 International C. elegans Meeting
    Paul Sternberg; Fiscal Year: 2001
    ..Previous C. elegans meetings have led to the exchange of knowledge, ideas, methods, mutants, and clones, and have been vital in fostering the sense of excitement, collegiality and cooperativity that characterize this field. ..