pupa

Summary

Summary: An inactive stage between the larval and adult stages in the life cycle of insects.

Top Publications

  1. ncbi Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling
    David R P Tree
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, CA 94305, USA
    Cell 109:371-81. 2002
  2. pmc Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cells
    L L Wong
    Biology Department, University of Virginia, Charlottesville 22901
    J Cell Biol 123:209-21. 1993
  3. ncbi Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing
    D I Strutt
    Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, S10 2TN, Sheffield, United Kingdom
    Mol Cell 7:367-75. 2001
  4. ncbi Spatial, temporal, and sexually dimorphic expression patterns of the fruitless gene in the Drosophila central nervous system
    G Lee
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurobiol 43:404-26. 2000
  5. ncbi Tissue polarity points from cells that have higher Frizzled levels towards cells that have lower Frizzled levels
    P N Adler
    Biology Department, University of Virginia, Charlottesville, Virginia 22903, USA
    Curr Biol 7:940-9. 1997
  6. ncbi Ectopic gene expression and homeotic transformations in arthropods using recombinant Sindbis viruses
    D L Lewis
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, University of Wisconsin, Madison, 53706, USA
    Curr Biol 9:1279-87. 1999
  7. ncbi The generation and diversification of butterfly eyespot color patterns
    C R Brunetti
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin-Madison, 1525 Linden Drive, Madison, WI 53706, USA
    Curr Biol 11:1578-85. 2001
  8. ncbi Reducing costs and operational constraints of dengue vector control by targeting productive breeding places: a multi-country non-inferiority cluster randomized trial
    W Tun-Lin
    Department of Medical Research, Yangon, Myanmar
    Trop Med Int Health 14:1143-53. 2009
  9. ncbi Spatial and temporal patterns in pupal and adult production of the dengue vector Aedes aegypti in Kamphaeng Phet, Thailand
    Constantianus J M Koenraadt
    Department of Entomology, University of California, Davis, California 95616, USA
    Am J Trop Med Hyg 79:230-8. 2008
  10. ncbi Expression of trypsin-like serine peptidases in pre-imaginal stages of Aedes aegypti (Diptera: Culicidae)
    Camila Mesquita-Rodrigues
    Laboratório de Biologia Molecular e Doenças Endêmicas, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil
    Arch Insect Biochem Physiol 76:223-35. 2011

Research Grants

Detail Information

Publications265 found, 100 shown here

  1. ncbi Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling
    David R P Tree
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, CA 94305, USA
    Cell 109:371-81. 2002
    ..This activity is linked to Frizzled activity on the adjacent cell surface. Prickle therefore functions in a feedback loop that amplifies differences between Frizzled levels on adjacent cell surfaces...
  2. pmc Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cells
    L L Wong
    Biology Department, University of Virginia, Charlottesville 22901
    J Cell Biol 123:209-21. 1993
    ..This suggests that the tissue polarity genes function in or on a pathway that controls hair polarity by regulating the subcellular location for prehair formation...
  3. ncbi Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing
    D I Strutt
    Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, S10 2TN, Sheffield, United Kingdom
    Mol Cell 7:367-75. 2001
    ..This differential receptor distribution may represent a novel mechanism for amplifying small differences in signaling activity across the axis of a cell...
  4. ncbi Spatial, temporal, and sexually dimorphic expression patterns of the fruitless gene in the Drosophila central nervous system
    G Lee
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurobiol 43:404-26. 2000
    ..Expression of sex-specific fru mRNAs in the CNS of males analyzed from the earliest pupal stages indicated that sex-specific alternative splicing is not the exclusive mechanism regulating expression of fruitless transcripts...
  5. ncbi Tissue polarity points from cells that have higher Frizzled levels towards cells that have lower Frizzled levels
    P N Adler
    Biology Department, University of Virginia, Charlottesville, Virginia 22903, USA
    Curr Biol 7:940-9. 1997
    ..Mutations in components of the fz signal transduction pathway disrupt tissue polarity; on the wing, hairs normally point distally but their polarity is altered by these mutations...
  6. ncbi Ectopic gene expression and homeotic transformations in arthropods using recombinant Sindbis viruses
    D L Lewis
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, University of Wisconsin, Madison, 53706, USA
    Curr Biol 9:1279-87. 1999
    ..Direct analysis of how a particular gene functions in a given species during development is hindered by the lack of broadly applicable techniques for manipulating gene expression...
  7. ncbi The generation and diversification of butterfly eyespot color patterns
    C R Brunetti
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin-Madison, 1525 Linden Drive, Madison, WI 53706, USA
    Curr Biol 11:1578-85. 2001
    ..Furthermore, the remarkably plastic regulatory interactions downstream of focal signaling have facilitated the evolution of eyespot diversity...
  8. ncbi Reducing costs and operational constraints of dengue vector control by targeting productive breeding places: a multi-country non-inferiority cluster randomized trial
    W Tun-Lin
    Department of Medical Research, Yangon, Myanmar
    Trop Med Int Health 14:1143-53. 2009
    ....
  9. ncbi Spatial and temporal patterns in pupal and adult production of the dengue vector Aedes aegypti in Kamphaeng Phet, Thailand
    Constantianus J M Koenraadt
    Department of Entomology, University of California, Davis, California 95616, USA
    Am J Trop Med Hyg 79:230-8. 2008
    ..Except for 2 (of 16) occasions, pupal, and adult populations were correlated strongly in time and space. Our results are consistent with application of the pupal survey technique for assessing dengue transmission risk...
  10. ncbi Expression of trypsin-like serine peptidases in pre-imaginal stages of Aedes aegypti (Diptera: Culicidae)
    Camila Mesquita-Rodrigues
    Laboratório de Biologia Molecular e Doenças Endêmicas, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil
    Arch Insect Biochem Physiol 76:223-35. 2011
    ..Comparative analysis between the proteolytic enzymes expressed by larvae and pupae showed that substantial changes in the expression of active trypsin-like serine proteases occur during the developmental cycle of A. aegypti...
  11. pmc Cell cycling and patterned cell proliferation in the Drosophila wing during metamorphosis
    M Milan
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Spain
    Proc Natl Acad Sci U S A 93:11687-92. 1996
    ..The final number of cells of the wing is fixed independently of experimental perturbations that alter the cell division schedule. These results are discussed in the context of a model of wing morphogenesis...
  12. ncbi CPF and CPFL, two related gene families encoding cuticular proteins of Anopheles gambiae and other insects
    Toru Togawa
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    Insect Biochem Mol Biol 37:675-88. 2007
    ..The other CPFLs appear to contribute to larval cuticle. Recombinant CPF proteins did not bind to chitin in the assay we used...
  13. ncbi Morphological and developmental analysis of peripheral antennal chemosensory sensilla and central olfactory glomeruli in worker castes of Camponotus compressus (Fabricius, 1787)
    Keshava Mysore
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India
    Arthropod Struct Dev 39:310-21. 2010
    ..Our findings provide the basis for future manipulative developmental studies on the role of sensory afferent number in glomerular development of different castes within the same species...
  14. ncbi Formation of the male-specific muscle in female Drosophila by ectopic fruitless expression
    K Usui-Aoki
    School of Human Sciences and Advanced Research Institute for Science and Engineering, Waseda University, 2 579 15, Mikajima, Tokorozawa 359 1192, Japan
    Nat Cell Biol 2:500-6. 2000
    ....
  15. ncbi Genetic sexing strains in medfly, Ceratitis capitata, sterile insect technique programmes
    A S Robinson
    Entomology Unit, FAO IAEA Agriculture and Biotechnology Laboratory, A 2444, Seibersdorf, Austria
    Genetica 116:5-13. 2002
    ..Some of the many field trials of the strains that were carried out before the strains were introduced into operational programmes are reviewed and an overview is given of their current use...
  16. pmc Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function
    R G Fehon
    Department of Cell Biology, Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06511
    J Cell Biol 113:657-69. 1991
    ..Our data suggest instead that Notch may act as a cell-surface receptor, perhaps functioning in the lateral inhibition mechanism that is necessary for proper spacing of neuronal precursors...
  17. ncbi Twist and Notch negatively regulate adult muscle differentiation in Drosophila
    S Anant
    National Centre for Biological Sciences, Bangalore, India
    Development 125:1361-9. 1998
    ....
  18. ncbi Hox-mediated regulation of doublesex sculpts sex-specific abdomen morphology in Drosophila
    Wei Wang
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama 35487, USA
    Dev Dyn 241:1076-90. 2012
    ..Together these transcription factors regulate numerous sex-specific characters, including pigmentation, cuticle morphology, and abdominal segment number...
  19. ncbi Dry season production of filariasis and dengue vectors in American Samoa and comparison with wet season production
    Barrot H Lambdin
    Department of Global Environmental Health, Emory University, Rollins School of Public Health, Atlanta, Georgia, USA
    Am J Trop Med Hyg 81:1013-9. 2009
    ..The high productivity for Ae. polynesiensis and Ae. aegypti pupae during the wet and dry seasons suggests that dengue and lymphatic filariasis transmission can occur throughout the year, consistent with the reporting of dengue cases...
  20. ncbi Kinesin II is required for cell survival and adherens junction positioning in Drosophila photoreceptors
    Bibhash Mukhopadhyay
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA
    Genesis 48:522-30. 2010
    ..These findings suggest that Kinesin II complex plays a cell type-specific function in the localization of AJ and cell polarity proteins in the developing retina, thereby contributing to photoreceptor morphogenesis...
  21. pmc Role of spastin in apical domain control along the rhabdomere elongation in Drosophila photoreceptor
    Geng Chen
    Department of Biology, Baylor University, Waco, Texas, United States of America
    PLoS ONE 5:e9480. 2010
    ..Mutations in spastin are the most common cause of hereditary spastin paraplegia, a neurodegenerative disease. In this study, the role of spastin was examined in Drosophila photoreceptor development...
  22. ncbi Use of the pupal survey technique for measuring Aedes aegypti (Diptera: Culicidae) productivity in Puerto Rico
    Roberto Barrera
    Dengue Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico
    Am J Trop Med Hyg 74:290-302. 2006
    ..Using number of Ae. aegypti larvae, Breteau Index, or the presence of immature forms as indicators of pupal productivity is not as efficient in identifying the most productive types of containers as direct pupal counts...
  23. pmc Transcription factor broad suppresses precocious development of adult structures during larval-pupal metamorphosis in the red flour beetle, Tribolium castaneum
    R Parthasarathy
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, United States
    Mech Dev 125:299-313. 2008
    ..These data suggest that the expression of Tcbr during the final instar larval stage promotes pupal program while suppressing the larval and adult programs ensuring a transitory pupal stage in holometabolous insects...
  24. ncbi Dengue and its vectors in Thailand: calculated transmission risk from total pupal counts of Aedes aegypti and association of wing-length measurements with aspects of the larval habitat
    Daniel Strickman
    Department of Entomology, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Am J Trop Med Hyg 68:209-17. 2003
    ..Such a system would combine the benefits of the simple application of larval surveillance with the valuable data gathered from pupal counts and wing measurements...
  25. ncbi Ecological factors influencing Aedes aegypti (Diptera: Culicidae) productivity in artificial containers in Salinas, Puerto Rico
    Roberto Barrera
    Dengue Branch, DVBID, Centers for Disease Control and Prevention, 1324 Calle Caniada, San Juan, Puerto Rico 00920
    J Med Entomol 43:484-92. 2006
    ..aegypti productivity and removal or control of shaded, larger containers would eliminate the production of the largest emerging mosquito females in the study area...
  26. ncbi Biochemical and cytoimmunological evidence for the control of Aedes aegypti larval trypsin with Aea-TMOF
    Dov Borovsky
    University of Florida IFAS, Florida Medical Entomology Laboratory, Vero Beach, 32962, USA
    Arch Insect Biochem Physiol 55:124-39. 2004
    ..These results indicate that TMOF-immunoreactive material is synthesized in sugar-fed male and female adults and larvae by the central nervous system cells...
  27. ncbi Critical evaluation of quantitative sampling methods for Aedes aegypti (Diptera: Culicidae) immatures in water storage containers in Vietnam
    Tessa B Knox
    Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Brisbane, Australia
    J Med Entomol 44:192-204. 2007
    ..610 and 0.328, respectively); however, the relationship between immature abundance and emergent adult populations remains to be defined...
  28. ncbi Brain development in the yellow fever mosquito Aedes aegypti: a comparative immunocytochemical analysis using cross-reacting antibodies from Drosophila melanogaster
    Keshava Mysore
    Biozentrum, University of Basel, Klinglebergstrasse 50, CH 4056 Basel, Switzerland
    Dev Genes Evol 221:281-96. 2011
    ..Taken together, this investigation forms the basis for future cellular and molecular investigations of brain development in this important disease vector...
  29. ncbi Hymenopteran parasitoids of forensic importance: host associations, seasonality, and prevalence of parasitoids of carrion flies in Western Australia
    Sasha C Voss
    Centre for Forensic Science M420, The University of Western Australia, 35 Stirling Hwy, Crawley, Western Australia 6009, Australia
    J Med Entomol 46:1210-9. 2009
    ..zealandicus and N. vitripennis parasitizing the dipteran species Calliphora albifrontalis Malloch (Calliphoridae), Calliphora dubia Macquart (Calliphoridae), and Hydrotaea rostrata Robineau-Desvoidy (Muscidae)...
  30. ncbi Use of the pupal/demographic-survey technique to identify the epidemiologically important types of containers producing Aedes aegypti (L.) in a dengue-endemic area of Venezuela
    A E Lenhart
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, U K
    Ann Trop Med Parasitol 100:S53-S59. 2006
    ..By targeting only those domestic breeding containers that produce the greatest number of pupae, control efforts may be streamlined to have the greatest impact on reducing the local adult Ae. aegypti population...
  31. ncbi Virtual forensic entomology: improving estimates of minimum post-mortem interval with 3D micro-computed tomography
    Cameron S Richards
    Department of Entomology, Natural History Museum, Cromwell Rd, London SW7 5BD, UK
    Forensic Sci Int 220:251-64. 2012
    ..Age specific developmental characters are described. The technique could be used as a measure to estimate a minimum post-mortem interval in cases of suspicious death where pupae are the oldest stages of insect evidence collected...
  32. pmc Safety and immunogenicity of H5N1 influenza vaccine based on baculovirus surface display system of Bombyx mori
    Rongzhong Jin
    College of Life Sciences, Zhejiang University, Hangzhou, China
    PLoS ONE 3:e3933. 2008
    ..375 mg/kg in rats and 3.2 mg/kg in cynomolgus monkeys. Our work showed the vaccine may be a candidate for a highly effective, cheap, and safe influenza vaccine for use in humans...
  33. ncbi Inturned localizes to the proximal side of wing cells under the instruction of upstream planar polarity proteins
    Paul N Adler
    Biology Department, Morphogenesis and Regenerative Medicine, Institute and Cancer Center, University of Virginia, Charlottesville, Virginia 22903, USA
    Curr Biol 14:2046-51. 2004
    ..These data indicate that accumulation of proteins at the proximal side of wing cells is a key event for the distal activation of the cytoskeleton to form a hair...
  34. ncbi Three calibration factors, applied to a rapid sweeping method, can accurately estimate Aedes aegypti (Diptera: Culicidae) pupal numbers in large water-storage containers at all temperatures at which dengue virus transmission occurs
    C M E Romero-Vivas
    Grupo de Investigaciones en Enfermedades Tropicales, Departamento de Ciencias Básicas Médicas
    J Med Entomol 44:930-7. 2007
    ..aegypti control programs in dengue virus-endemic areas throughout the world...
  35. pmc Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signaling
    Mark Charlton-Perkins
    Department of Pediatric Ophthalmology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Neural Dev 6:20. 2011
    ..However, many questions remain unanswered related to how downstream events of these two signaling pathways mediate distinct cell fate decisions...
  36. ncbi Identification of conserved microRNAs in Bombyx mori (silkworm) and regulation of fibroin L chain production by microRNAs in heterologous system
    Jun Cao
    Institute of Biochemistry, College of Life Science, Zijingang Campus, Zhejiang University, Hangzhou, PR China
    Insect Biochem Mol Biol 38:1066-71. 2008
    ..Clearly, agroinfiltration proved a highly efficient method to identify the function of miRNAs inhibiting their targets mRNA in heterologous system...
  37. pmc Proteolytic profiling and comparative analyses of active trypsin-like serine peptidases in preimaginal stages of Culex quinquefasciatus
    Andre Borges-Veloso
    Laboratório de Biologia Molecular e Doenças Endêmicas, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brazil
    Parasit Vectors 5:123. 2012
    ..This study presents zymographic characterization and comparative analysis of the proteolytic activity found in eggs, larval instars and pupae of Culex quinquefasciatus...
  38. ncbi Response to selection on cold tolerance is constrained by inbreeding
    Anneke Dierks
    Zoological Institute and Museum, University of Greifswald, J S Bachstraße 11 12, D 17489 Greifswald, Germany
    Evolution 66:2384-98. 2012
    ..Traits more closely related to fitness showed a clear fitness rebound, suggesting a trait-specific impact of purging. Our findings have important implications for the longer term survival of small populations in fragmented landscapes...
  39. ncbi Morphological comparison of pupal wing cuticle patterns in butterflies
    Joji M Otaki
    Department of Biological Sciences, Kanagawa University, 2946 Tsuchiya, Hiratsuka, Kanagawa 259 1293, Japan
    Zoolog Sci 22:21-34. 2005
    ....
  40. pmc Defensive abdominal rotation patterns of tenebrionid beetle, Zophobas atratus, pupae
    Toshio Ichikawa
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Insect Sci 12:133. 2012
    ..When an abdominal rotation was induced in a freely lying pupa, the rotation usually made the pupa move away from or turn its dorsum toward the source of stimulation with the aid ..
  41. ncbi Molecular characterization and immunohistochemical localization of a novel troponin C during silkworm development
    Jianqing Chen
    Institute of Biochemistry, Zhejiang Sci Tech University, Xiasha Higher Education Zone, Hangzhou, China
    Cell Tissue Res 331:725-38. 2008
    ..Our findings indicate that BmTnC is selectively expressed in the muscular tissues of the silkworm, including portions of the head, the Malpighian tubule, the body wall, and the gut...
  42. ncbi Ultrastructure and bacterial infection of wounds in honey bee ( Apis mellifera) pupae punctured by Varroa mites
    G Kanbar
    Fakultat fur Biologie, Zoologisches Institut, Entwicklungsphysiologie, Eberhard Karls Universitat, Auf der Morgenstelle 28, 72076, Tubingen, Germany
    Parasitol Res 90:349-54. 2003
    ..The ultrastructure of the pupal wounds, the bacterial colonies and the scarring process are documented by a series of scanning electron micrographs...
  43. ncbi Physiological and biochemical changes in summer and winter diapause and non-diapause pupae of the cabbage armyworm, Mamestra brassicae L. during long-term cold acclimation
    Lei Ding
    Faculty of Agriculture, Department of Bioprocess Engineering, Yamagata University, Tsuruoka 997 8555, Japan
    J Insect Physiol 49:1153-9. 2003
    ..To our knowledge, this is the first report to compare the physiological and biochemical differences among summer and winter diapause pupae and non-diapause pupae in the same insect species during long-term cold acclimation...
  44. ncbi Sequence and functional properties of Ets genes in the model organism Drosophila
    T Hsu
    Center for Molecular and Structural Biology, Hollings Cancer Center, and Department of Cell Biology and Anatomy, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, South Carolina, SC 29425, USA
    Oncogene 19:6409-16. 2000
    ..The information should be of significant value to the study of related processes in higher organisms due to the growing evidence for the cross species conservation of developmental mechanisms...
  45. ncbi Fast synaptic currents in Drosophila mushroom body Kenyon cells are mediated by alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors and picrotoxin-sensitive GABA receptors
    Hailing Su
    Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California 92697 1280, USA
    J Neurosci 23:9246-53. 2003
    ..Therefore, these receptors are also likely to mediate synaptic transmission in Kenyon cells in vivo and to contribute to plasticity during olfactory associative learning...
  46. pmc DRONC, an ecdysone-inducible Drosophila caspase
    L Dorstyn
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, PO Box 14, Rundle Mall, Adelaide, SA 5000, Australia
    Proc Natl Acad Sci U S A 96:4307-12. 1999
    ..These results suggest that DRONC is an effector of steroid-mediated apoptosis during insect metamorphosis...
  47. ncbi The cell adhesion molecule Roughest depends on beta(Heavy)-spectrin during eye morphogenesis in Drosophila
    Hyun Gwan Lee
    Department of Biology, Department of Biochemistry and Molecular Biology, Eberly College of Science, The Pennsylvania State University, University Park, PA 16802, USA
    J Cell Sci 123:277-85. 2010
    ..These results suggest that the apical spectrin membrane skeleton helps to coordinate the Cadherin-based ZA with Roughest-based morphogenesis...
  48. ncbi The role of Broad in the development of Tribolium castaneum: implications for the evolution of the holometabolous insect pupa
    Yuichiro Suzuki
    Department of Biology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
    Development 135:569-77. 2008
    ..is a key innovation that has led to the successful diversification of holometabolous insects, yet the origin of the pupa remains an enigma...
  49. ncbi Local induction of patterning and programmed cell death in the developing Drosophila retina
    D T Miller
    Washington University School of Medicine, Department of Molecular Biology and Pharmacology, Box 8103, St Louis, MO 63110, USA
    Development 125:2327-35. 1998
    ..Together, these signals refine the highly regular pattern observed in the adult retina...
  50. pmc Behavioral performance in adult honey bees is influenced by the temperature experienced during their pupal development
    Jurgen Tautz
    Lehrstuhl für Verhaltensphysiologie und Soziobiologie, Biozentrum, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Proc Natl Acad Sci U S A 100:7343-7. 2003
    ..5 degrees C performed significantly less well. We propose that the temperature at which pupae are raised will influence their behavioral performance as adults and may determine the tasks they carry out best inside and outside the hive...
  51. ncbi Ecological links between water storage behaviors and Aedes aegypti production: implications for dengue vector control in variable climates
    H Padmanabha
    Subdirección de Vigilancia y Control en Salud Publica, Instituto Nacional de Salud de Colombia, Cll 26 51 60 Bogota, Colombia
    Ecohealth 7:78-90. 2010
    ..aegypti production through human behavioral adaptations. Vector control programs should account for geographic variation in temperature and water usage behaviors in designing targeted interventions...
  52. ncbi Abnormalities of male-specific FRU protein and serotonin expression in the CNS of fruitless mutants in Drosophila
    G Lee
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 21:513-26. 2001
    ....
  53. pmc Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response
    Ingo Zinke
    Institut fur Genetik, Forschungszentrum Karlsruhe, Postfach 3640, D 76021 Karlsruhe, Germany
    EMBO J 21:6162-73. 2002
    ..The current analysis provides a basis for studying the genetic mechanisms underlying nutrient signalling...
  54. ncbi Can 29kDa rhGM-CSF expressed by silkworm pupae bioreactor bring into effect as active cytokine through orally administration?
    Yaozhou Zhang
    Institute of Biochemistry, Zhejiang Sci Tech University, Hangzhou 310018, China
    Eur J Pharm Sci 28:212-23. 2006
    ..These results proved that BmrhGM-CSF, a 29kDa glycoprotein expressed by Silkworm pupae bioreactor, could bring into the effect as active cytokine through oral administration...
  55. ncbi Characterization of a female-produced courtship pheromone in the parasitoid Nasonia vitripennis
    Sven Steiner
    Freie Universitat Berlin, Institut fur Biologie, Haderslebener Str 9, 12163, Berlin, Germany
    J Chem Ecol 32:1687-702. 2006
    ..These results suggest that sex-specific cuticular hydrocarbons are the key signals mediating the male courtship behavior in N. vitripennis...
  56. ncbi Inositol 1,4,5-trisphosphate receptor and dSTIM function in Drosophila insulin-producing neurons regulates systemic intracellular calcium homeostasis and flight
    Neha Agrawal
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
    J Neurosci 30:1301-13. 2010
    ....
  57. pmc Dynamic control of cell cycle and growth coupling by ecdysone, EGFR, and PI3K signaling in Drosophila histoblasts
    Nikolay Ninov
    Instituto de Biologia Molecular de Barcelona, Consejo Superior de Investigaciones Cientificas, Barcelona, Spain
    PLoS Biol 7:e1000079. 2009
    ..It sets the stage for the comprehensive understanding of the coordination of cell growth and cell-cycle progression in complex multicellular eukaryotes...
  58. ncbi Diverse developmental mechanisms contribute to different levels of diversity in horned beetles
    Armin P Moczek
    Department of Biology, Indiana University, Bloomington, IN, USA
    Evol Dev 7:175-85. 2005
    ..We discuss the implications of our results for our understanding of the evolution of horned beetle diversity and the origin and diversification of morphological novelties...
  59. ncbi Pupal-productivity surveys to identify the key container habitats of Aedes aegypti (L.) in Barranquilla, the principal seaport of Colombia
    C M E Romero-Vivas
    Grupo de Investigaciones en Enfermedades Tropicales, Departamento de Ciencias Básicas Médicas, Division Ciencias de la Salud, Universidad del Norte, Km 5 Antigua Via a Puerto Colombia, Barranquilla, Colombia
    Ann Trop Med Parasitol 100:S87-S95. 2006
    ..1% of all the pupae collected. These results, from a city where dengue fever is endemic, will help to focus local campaigns for Ae. aegypti source-reduction on the most productive categories of container...
  60. pmc Loss of flight and associated neuronal rhythmicity in inositol 1,4,5-trisphosphate receptor mutants of Drosophila
    Santanu Banerjee
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Gandhi Krishi Vigyan Kendra Campus, Bangalore 560065, India
    J Neurosci 24:7869-78. 2004
    ..InsP(3) receptor action appears to be important for normal development of the flight circuit and its central pattern generator...
  61. ncbi Temperature-related development of the parasitoid wasp Nasonia vitripennis as forensic indicator
    M Grassberger
    Institute for Anthropology, University of Vienna, Austria
    Med Vet Entomol 17:257-62. 2003
    ..8 degrees C (approximately 10 degrees C). Above this threshold, the overall thermal constant (K) for N. vitripennis was found to be 224.3+/-1.7 degree-days...
  62. ncbi The influence of late-stage pupal irradiation and increased irradiated: un-irradiated male ratio on mating competitiveness of the malaria mosquito Anopheles arabiensis Patton
    M E H Helinski
    International Atomic Energy Agency, Agency s Laboratories Seibersdorf, A 2444 Seibersdorf, Austria
    Bull Entomol Res 99:317-22. 2009
    ..In addition, cooling might be a useful tool to facilitate handling processes of large numbers of mosquitoes in genetic control programmes...
  63. pmc Genomic and functional studies of Drosophila sex hierarchy regulated gene expression in adult head and nervous system tissues
    Thomas D Goldman
    Section of Molecular and Computational Biology, Department of Biological Sciences, University of Southern California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 3:e216. 2007
    ..We show that dpr and dpr-expressing cells are required for the proper timing of male courtship behaviors...
  64. ncbi Restricted expression of the irreC-rst protein is required for normal axonal projections of columnar visual neurons
    T Schneider
    Institut fur Biologie III, Albert Ludwigs Universitat Freiburg, Germany
    Neuron 15:259-71. 1995
    ..Epigenesis of the phenotypes can be explained partially on the bases of homophilic irreC-rst interactions...
  65. ncbi Development of the indirect flight muscles of Drosophila
    J Fernandes
    Molecular Biology Unit, Tata Institute of Fundamental Research, Colaba, Bombay, India
    Development 113:67-77. 1991
    ..By morphological criteria and by patterns of specific gene expression, our experiments define events in IFM development...
  66. ncbi Insights into the molecular basis of the hormonal control of molting and metamorphosis from Manduca sexta and Drosophila melanogaster
    Lynn M Riddiford
    Department of Biology, University of Washington, 24 Kincaid Hall, Box 351800, Seattle, WA 98195 1800, USA
    Insect Biochem Mol Biol 33:1327-38. 2003
    ..Premature expression of different Broad isoforms also is shown to cause precocious degeneration of the prothoracic glands as well as to prevent ecdysteroid release during its presence...
  67. ncbi [Biological aspects and external morphology of immature stages of Memphis moruus stheno (Prittwittz) (Lepidoptera: Nymphalidae)]
    Fernando M S Dias
    Depto de Zoologia, Univ Federal do Paraná, Curitiba, PR, Brazil, 81531 980
    Neotrop Entomol 39:400-13. 2010
    ..Descriptions, illustrations and photographs of egg, all five instars and pupa are given. The cephalic morphology and chaetotaxy of first instar were described and illustrated...
  68. pmc Nonautonomous apoptosis is triggered by local cell cycle progression during epithelial replacement in Drosophila
    Yu Ichiro Nakajima
    Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mol Cell Biol 31:2499-512. 2011
    ..The replacement boundary, formed as caspase activation is regulated locally by cell-cell communication, may drive the dynamic orchestration of cell replacement during tissue remodeling...
  69. ncbi Assessment of a new strategy, based on Aedes aegypti (L.) pupal productivity, for the surveillance and control of dengue transmission in Thailand
    P Barbazan
    Centre for Vectors and Vector Borne Diseases, Mahidol University at Salaya, Nakhon Pathom 73170, Thailand
    Ann Trop Med Parasitol 102:161-71. 2008
    ..If even such targeted treatment is to be sustainable, however, it will have to be integrated, as one of several activities in which the at-risk communities are encouraged to participate...
  70. ncbi Larval cannibalism and pupal defense against cannibalism in two species of tenebrionid beetles
    Toshio Ichikawa
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    Zoolog Sci 26:525-9. 2009
    ..In contrast, only a few pupae of Z. atratus and several pupae of T. molitor were cannibalized when the VNC was Intact. The abdominal rotation response of the pupae thus functions as an effective defense against larval cannibalism...
  71. ncbi The diapause hormone-pheromone biosynthesis activating neuropeptide gene of Helicoverpa armigera encodes multiple peptides that break, rather than induce, diapause
    Tian Yi Zhang
    Department of Molecular and Cell Biology, University of Science and Technology of China, Hefei 230027
    J Insect Physiol 50:547-54. 2004
    ..This result suggests a possible mechanism of response for the signals of DH and other FXPRLamide peptides in H. armigera...
  72. pmc Advantages of larval control for African malaria vectors: low mobility and behavioural responsiveness of immature mosquito stages allow high effective coverage
    Gerry F Killeen
    Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University Health Sciences Centre, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA
    Malar J 1:8. 2002
    ....
  73. ncbi Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division
    Y Bellaiche
    Ecole Normale Superieure, UMR 8544, 46, rue d Ulm, 75230 Paris Cedex 05, France
    Nat Cell Biol 3:50-7. 2001
    ..In the Drosophila pupa, the pI sense organ precursor cell is polarized along the anterior-posterior axis of the fly and divides ..
  74. ncbi Identifying fly puparia by clearing technique: application to forensic entomology
    Kabkaew L Sukontason
    Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand
    Parasitol Res 101:1407-16. 2007
    ..This provides a key to identifying the puparia of these seven fly species...
  75. ncbi Regulation of swimming in the Culex pipiens (Diptera, Culicidae) pupa: kinematics and locomotory trajectories
    J Brackenbury
    Department of Anatomy, Downing Street, Cambridge, CB2 3DY, UK
    J Exp Biol 202:2521-9. 1999
    ..videography was used to investigate swimming kinematics and locomotory trajectories during escape responses in the pupa of Culex pipiens (Diptera, Culicidae)...
  76. pmc Dynamic decapentaplegic signaling regulates patterning and adhesion in the Drosophila pupal retina
    Julia B Cordero
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    Development 134:1861-71. 2007
    ....
  77. ncbi Aedes aegypti pupal/demographic surveys in southern Mexico: consistency and practicality
    J I Arredondo-Jimenez
    Centro de Investigacion de Paludismo, Instituto Nacional de Salud Publica, Apartado Postal 537, Tapachula, Chiapas 30700, Mexico
    Ann Trop Med Parasitol 100:S17-S32. 2006
    ..The methodology for pupal/demographic surveys appears to be practical and to give consistent results, although it remains to be seen if monitoring of pupal productivity can adequately reflect the impact of vector-control interventions...
  78. pmc Why are two different cross-linkers necessary for actin bundle formation in vivo and what does each cross-link contribute?
    L G Tilney
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Cell Biol 143:121-33. 1998
    ..Thus, forked aligns the filaments and then directs fascin binding so that inappropriate cross-linking does not occur...
  79. ncbi Cuticular hydrocarbon composition in pupal exuviae for taxonomic differentiation of six necrophagous flies
    Gongyin Ye
    Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310029, China
    J Med Entomol 44:450-6. 2007
    ..These results indicate that cuticular hydrocarbons as chemotaxonomic characters for insects of forensic importance are of high value and feasibility...
  80. ncbi Postlarval fitness of transgenic strains of Cochliomyia hominivorax (Diptera: Calliphoridae)
    Margaret L Allen
    Midwest Livestock Insects Research Unit, USDA ARS, 305 Plant Industry Building, University of Nebraska East Campus, Lincoln, NE 68583, USA
    J Econ Entomol 97:1181-5. 2004
    ..Hence, the presence of the transgene used to produce the strains tested did not incur a fitness cost to the colonies of laboratory-reared C. hominivorax...
  81. pmc Construction of a full-length cDNA Library from Chinese oak silkworm pupa and identification of a KK-42-binding protein gene in relation to pupa-diapause termination
    Yu Ping Li
    Shenyang Agricultural University, China
    Int J Biol Sci 5:451-7. 2009
    ..Total RNA was extracted from a single fresh female pupa at the diapause stage...
  82. ncbi Pupation by Viburnum leaf beetle (coleoptera: chrysomelidae): behavioral description and impact of environmental variables and entomopathogenic nematodes
    Paul A Weston
    Department of Entomology, Cornell University, Ithaca, NY, USA
    Environ Entomol 37:845-9. 2008
    ..bacteriophora consistently (but not significantly) more effective than S. carpocapsae. Management methods that take advantage of pupation behaviors are discussed...
  83. pmc The Drosophila Stubble-stubbloid gene encodes an apparent transmembrane serine protease required for epithelial morphogenesis
    L F Appel
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Proc Natl Acad Sci U S A 90:4937-41. 1993
    ....
  84. ncbi The effects of temperature, diet, and other factors on development, survivorship, and oviposition of Aethina tumida (Coleoptera: Nitidulidae)
    William G Meikle
    Kika de la Garza Subtropical Agricultural Research Center, USDA Agricultural Research Service, 2413 E Highway 83, Weslaco, TX 78596, USA
    J Econ Entomol 104:753-63. 2011
    ..7 times more eggs per female than those kept as single pairs. Overall, beetles fared best at 28-32 degrees C with mortality of all stages highest at 35 degrees C...
  85. ncbi The defensive secretion of Carabus lefebvrei Dejean 1826 pupa (Coleoptera, Carabidae): gland ultrastructure and chemical identification
    Anita Giglio
    Department of Ecology, University of Calabria, via P Bucci cubo 4B, Arcavacata di Rende CS, Calabria, Italy
    Microsc Res Tech 72:351-61. 2009
    ..We supposed that ketones, aldehydes, alcohols, esters, and carboxylic acids have a deterrent function against the predators and monoterpenes provide a prophylaxis function against pathogens...
  86. ncbi Silk and silkworm pupa peptides suppress adipogenesis in preadipocytes and fat accumulation in rats fed a high-fat diet
    Sun Hee Lee
    College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, 52 Naesudongro, Gaesin dong, Cheongju, Chungbuk 361 763, Korea
    Eur J Nutr 51:1011-9. 2012
    The objective was to confirm the anti-obesity activity of a silk peptide (SP) and a silkworm pupa peptide (SPP) in rats fed a high-fat diet (HFD) and to elucidate their action mechanism(s) in a preadipocyte culture system.
  87. ncbi Parental exposure to low-dose X-rays in Drosophila melanogaster induces early emergence in offspring, which can be modulated by transplantation of polar cytoplasm
    Tomoko Kanao
    Department of Radiological Sciences, International University of Health and Welfare, Kitakanemaru 2600 1, Ohtawara shi, Tochigi ken 324 8501, Japan
    Mutat Res 527:1-6. 2003
    ..These results show that radiation-induced effects can be transmitted to the next generation through the germ cell line...
  88. pmc The shavenoid gene of Drosophila encodes a novel actin cytoskeleton interacting protein that promotes wing hair morphogenesis
    Nan Ren
    Biology Department, Cancer Center and Morphogenesis and Regenerative Medicine Institute, University of Virginia, Charlottesville, Virginia 22903, USA
    Genetics 172:1643-53. 2006
    ..We found a strong genetic interaction between mutations in these genes consistent with their having a close but parallel functional relationship...
  89. ncbi Distinct roles for the actin and microtubule cytoskeletons in the morphogenesis of epidermal hairs during wing development in Drosophila
    C M Turner
    Biology Department and Cancer Center, University of Virginia, Charlottesville 22903, USA
    Mech Dev 70:181-92. 1998
    ..This is a phenocopy of mutations in crinkled, and suggests mutations that cause branched hairs will be in genes that encode products that interact with the actin cytoskeleton...
  90. ncbi Abridged pupa identification key to the common container-breeding mosquitoes in urban Southeast Asia
    Michael J Bangs
    US Naval Medical Research Unit No 2, Kompleks P2M LitBangKes, Jakarta, Indonesia
    J Am Mosq Control Assoc 22:565-72. 2006
    ..Examination of pupae for the identification of various container-inhabiting mosquito genera and target aedine species proved to be accurate and far less time-consuming and problematic than rearing pupae to adults...
  91. ncbi Combinatorial chemistry in insects: a library of defensive macrocyclic polyamines
    F C Schröder
    Department of Chemistry, Cornell University, Ithaca, NY 14853, USA
    Science 281:428-31. 1998
    ..The combinatorial assembly of these simple building blocks generates a high degree of structural diversity, which is further increased by slow, spontaneous intramolecular rearrangement of the macrocycles...
  92. ncbi Durations of immature stage development period of Nasonia vitripennis (Walker) (Hymenoptera: Pteromalidae) under laboratory conditions: implications for forensic entomology
    Renata da Silva Mello
    Programa de Pós graduação em Biologia Animal, Instituto de Biologia, Universidade Federal Rural do Rio de Janeiro UFRRJ, Rodovia BR 465 Km 7, 23890 000 Seropédica, Rio de Janeiro, Brazil
    Parasitol Res 104:411-8. 2009
    ..associations between female parasitoids and pupae of Chrysomya megacephala, which were defined by: (a) one pupa was exposed to different numbers of female parasitoids (1:1, 1:3, 1:5, 1:7, 1:9, 1:11) and (b) different numbers of ..
  93. ncbi Development of Spalangia cameroni and Muscidifurax raptor (Hymenoptera: Pteromalidae) on live house fly (Diptera: Muscidae) pupae and pupae killed by heat shock, irradiation, and cold
    C J Geden
    USDA ARS, Center for Medical, Agricultural and Veterinary Entomology, 1600 SW 23rd Dr, Gainesville, FL 32608, USA
    Environ Entomol 36:34-9. 2007
    ..Killing pupae by heat shock provides a simple and low-cost method for stockpiling high-quality hosts for mass-rearing both of these filth fly biological control agents...
  94. ncbi The cold-sensitive period for frizzled in the development of wing hair polarity ends prior to the start of hair morphogenesis
    P N Adler
    Biology Department, University of Virginia, Charlottesville 22903 2477
    Mech Dev 46:101-7. 1994
    ..Our data argue that fz has a regulatory function in specifying where the prehair forms, but no role in the actual morphogenesis of the prehair...
  95. ncbi Isolation of mannose-binding C-type lectin from Heliothis virescens pupae
    Donald D Ourth
    Department of Biology, The University of Memphis, Memphis, TN 38152 3560, USA
    Biochem Biophys Res Commun 335:1085-9. 2005
    ..The presence of MBL in insect pupae has not before been reported and could be important in pupal innate immunity to bacterial infection...
  96. ncbi Longevity and reproductive success of Aethina tumida (Coleoptera: Nitidulidae) fed different natural diets
    James D Ellis
    Rhodes University Department of Zoology and Entomology, Grahamstown, South Africa
    J Econ Entomol 95:902-7. 2002
    ..tumida are efficient at causing large-scale damage to colonies of honey bees resulting in economic injury for the beekeeper. Practical considerations for the control of A. tumida are briefly discussed...
  97. pmc Role of kinesin heavy chain in Crumbs localization along the rhabdomere elongation in Drosophila photoreceptor
    Garrett P League
    Department of Biology, Baylor University, Waco, Texas, United States of America
    PLoS ONE 6:e21218. 2011
    ..This study has examined whether Kinesin heavy chain (Khc), a subunit of the microtubule-based motor Kinesin-1, is essential in polarity protein localization in developing photoreceptors...
  98. ncbi Circadian clocks and life-history related traits: is pupation height affected by circadian organization in Drosophila melanogaster?
    Dhanashree A Paranjpe
    Chronobiology Laboratory, Jawaharlal Nehru Centre for Advanced Scientific Research, P O Box 6436, Jakkur, Bangalore 560 064, India
    J Genet 83:73-7. 2004
    ..We briefly discuss these results in the context of the possible involvement of circadian clocks in life-history evolution...
  99. ncbi Mutation of twins encoding a regulator of protein phosphatase 2A leads to pattern duplication in Drosophila imaginal discs
    T Uemura
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Genes Dev 7:429-40. 1993
    ..These results suggest a novel aspect of physiological roles of protein dephosphorylation; that is, the control of PP2A activity is crucial for specification of tissue patterns...
  100. ncbi Requirement of the roughest gene for differentiation and time of death of interommatidial cells during pupal stages of Drosophila compound eye development
    Helena Araujo
    Departamento de Embriologia e Histologia, Universidade Federal do Rio de Janeiro, 21949 900, Rio de Janeiro, Brazil
    Mech Dev 120:537-47. 2003
    ....
  101. ncbi Description of the pupa of the Himalayan mosquito, Ochlerotatus pulchriventer
    Richard F Darsie
    Department of Biology, Grove City College, PA 16127, USA
    J Am Mosq Control Assoc 25:248-50. 2009
    The pupa of Ochlerotatus pulchriventer (=Aedes pulchriventer) is described and illustrated for the first time. It was collected at midrange altitudes in the Himalaya Mountains of Nepal. A subspecies from Taiwan is discussed.

Research Grants38

  1. CHEMISTRY OF ARTHROPOD SECRETIONS
    Jerrold Meinwald; Fiscal Year: 2007
    ..abstract_text> ..
  2. Molecular genetic control of the immature female mosquito vector
    Helen Benes; Fiscal Year: 2012
    ....
  3. Exploring the Venom Repertoire of Parasitoids
    JOHN HAYNES WERREN; Fiscal Year: 2013
    ..The project combines genetic, proteomic, physiological and evolutionary approaches to explore function, diversity, and potential for drug discovery in the immense pool of parasitoid venom proteins. ..
  4. Glial remodeling in Drosophila: proliferation, membrane outgrowth and nerve enshe
    Joyce J Fernandes; Fiscal Year: 2012
    ..They are generated in the embryo and undergo bouts of proliferation in the larva and later in the pupa when the adult nervous system is being re-organized...
  5. INSECT PROJECTIN: ROLES IN SARCOMERE ASSEMBLY & FLIGHT
    Agnes Ayme Southgate; Fiscal Year: 2005
    ..The main goal is to expose them to the research environment, and to teach them the scientific methods including designing, preparing, performing and analyzing their own experiments. ..
  6. NEUROENDOCRINE CONTROL OF INSECT DEVELOPMENT
    Daniel Gibbs; Fiscal Year: 1980
    ..contain prothoracicotropic hormone (PTTH), which controls the events of larval molting, metamorphosis of larva to pupa, and development of the pupa to the adult insect...
  7. MOSQUITOES OF MIDDLE AMERICA
    JOHN BELKIN; Fiscal Year: 1980
    ..3) To describe and illustrate in detail every species in every state (female, male, pupa, 4th-instar larva) on the basis of individually associated reared material from type localities insofar as possible...
  8. Role of uPA and uPAR in Human Glioma Invasiveness
    JASTI RAO; Fiscal Year: 2009
    ..Determine the effect of vectors expressing siRNA against uPAR and uPA single or bicistronic constructs (puPAR, puPA and pU2) on uPAR and uPA levels in glioblastoma cell lines. Ib...
  9. N-3 fatty acid & binding protein MRG on mammary tumor
    YUENIAN SHI; Fiscal Year: 2006
    ..These studies will help to identify MRG as mediator for differentiation for mammary gland and for interaction with n-3 PUPA on inhibition of mammary tumorigenesis.
  10. GENETIC ANALYSIS OF PREHAIR MORPHOGENESIS
    Paul Adler; Fiscal Year: 2005
    ....
  11. Novel Genes Involved in Drug Response
    Ruthann Nichols; Fiscal Year: 2002
    ..Ultimately, our research will determine the role of these gene products in mediating the effect of nicotine in humans. ..
  12. Intracellular transfer of cholesterol in mosquitoes
    Que Lan; Fiscal Year: 2010
    ..The results will also validate the potential of targeting cholesterol metabolism for the development of new strategies to control mosquito populations. ..
  13. Hormonal Control of Insect Epidermis
    Lynn Riddiford; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  14. Genetics of Wing and Cell-Size Evolution in Nasonia
    John Werren; Fiscal Year: 2008
    ....
  15. Mechanisms of Steroid-Triggered Programmed Cell Death
    CARL THUMMEL; Fiscal Year: 2009
    ..Finally, our studies provide a foundation for determining how steroids control cell death in humans, with implications for understanding and treating human disease. ..
  16. A Novel Virus that Infects & Sterilizes Insect Vectors of Human Disease
    Drion Boucias; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  17. Exploring TSLP as a Key Initiator and Novel Therapeutic Target for Asthma
    Baohua Zhou; Fiscal Year: 2008
    ..Our goal is to elucidate the roles of thymic stromal lymphopoietin (TSLP) in the pathogenesis of asthma and explore TSLP as a novel therapeutic target to prevent and/or control the disease. [unreadable] [unreadable] [unreadable]..
  18. HORMONE ACTION ON THE CNS
    JAMES TRUMAN; Fiscal Year: 2009
    ..Understanding these issues is fundamental to normal brain development and for using stem cells to repair brain disease. ..
  19. REGULATION OF INSECT JUVENILE HORMONE BIOSYNTHESIS
    LINDA RESTIFO; Fiscal Year: 2001
    ..The study of CYP4C7 is a first and unique opportunity to study the processes by which the corpora allata are turned off. These processes have until now been addressed mostly at the morphological level. ..
  20. L1-MEDIATED RECRUITMENT OF THE MEMBRANE SKELETON
    Michael Hortsch; Fiscal Year: 2002
    ..Finally, he will use this assay system to test whether mutant L1-CAM molecules from human patients will function in his assay. ..
  21. Functions and Interactions dFOXO in Drosopila Aging
    Marc Tatar; Fiscal Year: 2010
    ....
  22. Genetics of Reproductive Senescence
    Marc Tatar; Fiscal Year: 2010
    ..Coupled with the program-wide multidimensional measures of somatic aging, we shall evaluate the extent that reproductive and somatic aging are concordant or independent. ..
  23. The molecular basis of morphological evolution
    David L Stern; Fiscal Year: 2010
    ..This detailed analysis of gene regulation promises to provide new insights into how gene regulation functions and evolves in natural species to cause possibly adaptive changes in morphology. ..
  24. STEROID REGULATION OF PROGRAMMED CELL DEATH
    CARL THUMMEL; Fiscal Year: 2003
    ..In addition, this study will provide insight into the molecular mechanisms by which systemic hormonal signals are refined into stage- and tissue-specific biological responses during development. ..
  25. Nutritional and endocrine control of mosquito egg development.
    Aparna Telang; Fiscal Year: 2008
    ..Identification and characterization of these genes should expand our understanding of hematophagy and pathogen transmission in mosquito vectors. [unreadable] [unreadable] [unreadable] [unreadable]..
  26. Cellular Immune Response of Mosquitoes to Pathogens
    JULIAN HILLYER; Fiscal Year: 2003
    ..In understanding the immune response mounted by different insect species and strains toward pathogens, it may be possible to manipulate existing vectors to make the parasite/vector biologic interplay incompatible. ..
  27. SYNAPTIC CONNECTIVITY IN CENTRAL BRAIN
    Wayne Johnson; Fiscal Year: 2004
    ..abstract_text> ..
  28. A Drosophila model of Batten Disease
    Robert Glaser; Fiscal Year: 2004
    ..The specific aims of the proposal are: 1. Determine the phenotypic consequences of removing DmPPT1 function by gene mutation. 2. Determine the phenotypic consequences of disrupting DmPPT1 function by RNA interference. ..
  29. CONTROL OF CNS DEVELOPMENT BY BRC TRANSCRIPTION FACTORS
    LINDA RESTIFO; Fiscal Year: 2005
    ..Defining molecular pathways between hormonal signals and specific events in brain development should lead to better therapeutic strategies for treating CNS dysfunction due to congenital and acquired disorders. ..
  30. LONGEVITY/CANDIDATE GENE POLYMORPHISMS IN DROSOPHILA
    Marc Tatar; Fiscal Year: 2003
    ..The genotype-phenotype associations detected with this design will be of broad significance to the problem of genetic variation for longevity in general populations. ..
  31. MOLECULAR GENETICS OF PHOTOTRANSDUCTION
    Bih Hwa Shieh; Fiscal Year: 2006
    ..Un-regulated signaling may lead to hyperactivity or degeneration of neurons, which has been implicated in mans pathophysiological conditions such as epilepsy and neurodegenerative diseases. ..
  32. STEROID RECEPTORS AND CNS DEVELOPMENT
    JAMES TRUMAN; Fiscal Year: 2007
    ..5) Use EcR dominant-negative mutations to selectively suppress cytodynamic modules to establish the role of each on growth dynamics and on the final form of the arbor. ..
  33. DEVELOPMENTAL CHANGES IN NEURONAL FORM AND FUNCTION
    Janis Weeks; Fiscal Year: 2002
    ..These studies will contribute to the understanding of fundamental mechanisms by which steroid hormones control neuronal phenotype and survival, with the long-term goal of improving human health. ..
  34. Regulatory systems of Drosophila aging
    Marc Tatar; Fiscal Year: 2007
    ..In a comprehensive experimental design, we shall assess qualifies of stress resistance, central metabolism and mitochondria function to determine which feature best predicts variance in life span [unreadable] [unreadable]..
  35. CADDMR: a Cell-based Assay for Drug Discovery for Mental Retardation Disorders
    LINDA RESTIFO; Fiscal Year: 2007
    ..The proposed experiments are an important step toward that goal. [unreadable] [unreadable] [unreadable]..
  36. Mosquito-malaria interactions in the hemocoel
    JULIAN HILLYER; Fiscal Year: 2007
    ..Understanding the mechanisms used by parasites to complete their life cycle inside the vector, and the mechanisms used by the vector to kill parasites, may lead to novel transmission control strategies. [unreadable] [unreadable]..
  37. Anti-larval measures for malaria control in The Gambia
    Steven Lindsay; Fiscal Year: 2007
    ..The results from this study will make a major contribution to quantifying the importance of the use of Bs and Bti in the fight against malaria. ..
  38. Circadian control of a behavioral output
    John Ewer; Fiscal Year: 2007
    ..Thus it offers a unique opportunity to elucidate how the activity of the clock is coupled to the mechanism that controls a behavioral output. [unreadable] [unreadable] [unreadable]..