life cycle stages

Summary

Summary: The continuous sequence of changes undergone by metamorphosing insects and other animals during the post-embryonic development process.

Top Publications

  1. pmc Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites
    Tim Nicolai Siegel
    Laboratory of Molecular Parasitology, The Rockefeller University, New York, NY 10065, USA
    Nucleic Acids Res 38:4946-57. 2010
  2. pmc The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission
    Rita Tewari
    Institute of Genetics, QMC, University of Nottingham, Nottingham NG7 2UH, UK
    Cell Host Microbe 8:377-87. 2010
  3. ncbi Hydrodynamic flow-mediated protein sorting on the cell surface of trypanosomes
    Markus Engstler
    Institut fur Mikrobiologie und Genetik, Technische Universitat Darmstadt, Schnittspahnstrasse 10, 64287, Darmstadt, Germany
    Cell 131:505-15. 2007
  4. pmc Identification of the meiotic life cycle stage of Trypanosoma brucei in the tsetse fly
    Lori Peacock
    School of Biological Sciences, University of Bristol, Bristol BS8 1UG, United Kingdom
    Proc Natl Acad Sci U S A 108:3671-6. 2011
  5. pmc Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages
    Michael D Urbaniak
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom
    PLoS ONE 7:e36619. 2012
  6. ncbi Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination
    Timothy N C Wells
    Medicines for Malaria Venture, Geneva, Switzerland
    Trends Parasitol 26:145-51. 2010
  7. ncbi Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes
    Sharon Yeoh
    Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Cell 131:1072-83. 2007
  8. pmc Comparative proteomics of two life cycle stages of stable isotope-labeled Trypanosoma brucei reveals novel components of the parasite's host adaptation machinery
    Falk Butter
    Department of Proteomics, Max Planck Institute for Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Mol Cell Proteomics 12:172-9. 2013
  9. pmc The cell biology of Trypanosoma brucei differentiation
    Katelyn Fenn
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Curr Opin Microbiol 10:539-46. 2007
  10. ncbi Plasmodium falciparum gametocytes: still many secrets of a hidden life
    Pietro Alano
    Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena n 299, 00161 Rome, Italy
    Mol Microbiol 66:291-302. 2007

Detail Information

Publications288 found, 100 shown here

  1. pmc Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites
    Tim Nicolai Siegel
    Laboratory of Molecular Parasitology, The Rockefeller University, New York, NY 10065, USA
    Nucleic Acids Res 38:4946-57. 2010
    ..Our study demonstrates the usefulness of the RNA-seq technology to study the transcriptional landscape of an organism whose genome has not been fully annotated...
  2. pmc The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission
    Rita Tewari
    Institute of Genetics, QMC, University of Nottingham, Nottingham NG7 2UH, UK
    Cell Host Microbe 8:377-87. 2010
    ..Phenotyping mutants at four life cycle stages in Anopheles stephensi mosquitoes revealed functional clusters of kinases required for sexual development ..
  3. ncbi Hydrodynamic flow-mediated protein sorting on the cell surface of trypanosomes
    Markus Engstler
    Institut fur Mikrobiologie und Genetik, Technische Universitat Darmstadt, Schnittspahnstrasse 10, 64287, Darmstadt, Germany
    Cell 131:505-15. 2007
    ....
  4. pmc Identification of the meiotic life cycle stage of Trypanosoma brucei in the tsetse fly
    Lori Peacock
    School of Biological Sciences, University of Bristol, Bristol BS8 1UG, United Kingdom
    Proc Natl Acad Sci U S A 108:3671-6. 2011
    ..This is evidence of conventional meiotic division in an excavate protist, and the functional conservation of the meiotic machinery in these divergent organisms underlines the ubiquity and basal evolution of meiosis in eukaryotes...
  5. pmc Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages
    Michael D Urbaniak
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom
    PLoS ONE 7:e36619. 2012
    ..Our proteomic data is broadly in agreement with transcriptomic studies, but with significantly larger fold changes observed at the protein level than at the mRNA level...
  6. ncbi Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination
    Timothy N C Wells
    Medicines for Malaria Venture, Geneva, Switzerland
    Trends Parasitol 26:145-51. 2010
    ..New developments in cell biology are starting to open ways to the next generation of drugs against hypnozoites. This search is urgent, given the time needed to develop a new medication...
  7. ncbi Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes
    Sharon Yeoh
    Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Cell 131:1072-83. 2007
    ..Our findings reveal the presence in the malarial parasitophorous vacuole of a regulated, PfSUB1-mediated proteolytic processing event required for release of viable parasites from the host erythrocyte...
  8. pmc Comparative proteomics of two life cycle stages of stable isotope-labeled Trypanosoma brucei reveals novel components of the parasite's host adaptation machinery
    Falk Butter
    Department of Proteomics, Max Planck Institute for Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Mol Cell Proteomics 12:172-9. 2013
    ..isotope labeling by amino acids in cell culture in trypanosomes to compare the proteomes of two different life cycle stages. Quantitative comparison of 4364 protein groups identified many proteins previously not known to be stage-..
  9. pmc The cell biology of Trypanosoma brucei differentiation
    Katelyn Fenn
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Curr Opin Microbiol 10:539-46. 2007
    ..Interestingly, the new molecular discoveries provide insights into the biology of the parasite in the field...
  10. ncbi Plasmodium falciparum gametocytes: still many secrets of a hidden life
    Pietro Alano
    Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena n 299, 00161 Rome, Italy
    Mol Microbiol 66:291-302. 2007
    ....
  11. ncbi Improved synchronous production of Plasmodium falciparum gametocytes in vitro
    Quinton L Fivelman
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Mol Biochem Parasitol 154:119-23. 2007
    ..The protocol described lends itself to large scale culturing and harvesting of synchronous parasites suitable for biochemical assays, northern blots, flow cytometry, microarrays and proteomic analysis...
  12. ncbi Discovery of gene function by expression profiling of the malaria parasite life cycle
    Karine G Le Roch
    Department of Cell Biology ICND202, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 301:1503-8. 2003
    ..Genes with highly correlated levels and temporal patterns of expression were often involved in similar functions or cellular processes...
  13. pmc A cyclic GMP signalling module that regulates gliding motility in a malaria parasite
    Robert W Moon
    Wellcome Trust Sanger Institute, Cambridge Hinxton, United Kingdom
    PLoS Pathog 5:e1000599. 2009
    ..These data demonstrate an important function for signalling through cGMP, and most likely PKG, in dynamically regulating ookinete gliding during the transmission of malaria to the mosquito...
  14. pmc A differential role for actin during the life cycle of Trypanosoma brucei
    Jose A Garcia-Salcedo
    Laboratory of Molecular Parasitology, ULB Institute of Molecular Biology and Medicine, Gosselies, Belgium
    EMBO J 23:780-9. 2004
    ..However, the flagellar pocket was not affected. These findings suggest that trypanosomes have different functional requirements for actin during the bloodstream and procyclic phases of the life cycle...
  15. pmc Independent analysis of the flagellum surface and matrix proteomes provides insight into flagellum signaling in mammalian-infectious Trypanosoma brucei
    Michael Oberholzer
    Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA
    Mol Cell Proteomics 10:M111.010538. 2011
    ..The combined results indicate that the flagellum surface presents a diverse and dynamic host-parasite interface that is well-suited for host-parasite signaling...
  16. ncbi Dense granules: are they key organelles to help understand the parasitophorous vacuole of all apicomplexa parasites?
    Corinne Mercier
    Institut Jean Roget, Universite Joseph Fourier, CNRS UMR 5163, Place du Commandant Nal, 38700 La Tronche, France
    Int J Parasitol 35:829-49. 2005
    ..Conserved expression of the Toxoplasma dense granule proteins throughout most of the parasite stages suggests that they could also be key elements of the cyst formation...
  17. pmc A Mitogen-activated protein kinase controls differentiation of bloodstream forms of Trypanosoma brucei
    Debora Domenicali Pfister
    Institut fur Zellbiologie, Universitat Bern, Murtenstrasse 31, CH 3010 Bern, Switzerland
    Eukaryot Cell 5:1126-35. 2006
    ..Two independent knockout clones proliferated normally in culture and were not essential for other life cycle stages in the fly...
  18. pmc Stage-specific proteomic expression patterns of the human filarial parasite Brugia malayi and its endosymbiont Wolbachia
    Sasisekhar Bennuru
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:9649-54. 2011
    ..Parasite sex- and stage-specific protein expression identified those pathways related to parasite differentiation and demonstrates stage-specific expression by the Bm endosymbiont Wolbachia as well...
  19. ncbi Life cycle stages of the amphibian chytrid Batrachochytrium dendrobatidis
    Lee Berger
    Amphibian Disease Ecology Group, School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Queensland 4811, Australia
    Dis Aquat Organ 68:51-63. 2005
    ..Hyperkeratosis may be due to (1) a hyperplastic response that leads to an increased turnover of epidermal cells, and (2) premature keratinization and death of infected cells...
  20. ncbi A NIMA-related protein kinase is essential for completion of the sexual cycle of malaria parasites
    Luc Reininger
    INSERM U609, Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow G11 6NU, Scotland, United Kingdom
    J Biol Chem 280:31957-64. 2005
    ..Cell cycle progression in the zygote is identified as a likely precondition for its morphological transition to the ookinete and for the successful establishment of a malaria infection in the mosquito...
  21. ncbi Advances and perspectives in Leishmania cell based drug-screening procedures
    D Sereno
    IRD, UR008 Pathogénie des Trypanosomatidés, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    Parasitol Int 56:3-7. 2007
    ....
  22. ncbi Evaluation of reference genes for quantitative polymerase chain reaction across life cycle stages and tissue types of Tribolium castaneum
    Michelle J Toutges
    Center for Grain and Animal Health Research, Agricultural Research Service, U S Department of Agriculture, 1515 College Avenue, Manhattan, Kansas 66502, USA
    J Agric Food Chem 58:8948-51. 2010
    ....
  23. pmc Host identity matters in the amphibian-Batrachochytrium dendrobatidis system: fine-scale patterns of variation in responses to a multi-host pathogen
    Stephanie Gervasi
    Department of Zoology, Oregon State University, Corvallis, Oregon, USA
    PLoS ONE 8:e54490. 2013
    ..We show that variation in susceptibility to this multi-host pathogen is complex when viewed at a fine-scale and may be mediated through intrinsic host traits...
  24. pmc Hung out to dry: choice of priority ecoregions for conserving threatened neotropical anurans depends on life-history traits
    Rafael Dias Loyola
    Programa de Pos Graduacao em Ecologia, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Sao Paulo, Brazil
    PLoS ONE 3:e2120. 2008
    ....
  25. ncbi Identification of Echinococcus granulosus microRNAs and their expression in different life cycle stages and parasite genotypes
    M Cucher
    Departamento de Microbiologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Piso 13, 1121 Buenos Aires, Argentina
    Int J Parasitol 41:439-48. 2011
    ..Understanding the developmental processes of E. granulosus may help to find new strategies for the control of cystic hydatid disease, caused by the metacestode stage of the parasite...
  26. ncbi Schistosoma mansoni: molecular characterization of Alkaline Phosphatase and expression patterns across life cycle stages
    B O Araujo-Montoya
    Centro de Biotecnologia, Instituto Butantan, Av Vital Brazil 1500, Sao Paulo, SP, Brazil
    Exp Parasitol 129:284-91. 2011
    ..was quantitatively supported by its enzymatic activity in live ex vivo or cultured parasites throughout the life cycle stages. The fact that cercariae accumulate large amounts of SmAP mRNA, which rapidly translates into protein upon ..
  27. ncbi Aspects of Trypanosoma cruzi stage differentiation
    Samuel Goldenberg
    Instituto Carlos Chagas, ICC Fiocruz PR, Rua Prof Algacyr Munhoz Mader, Curitiba, PR, Brazil
    Adv Parasitol 75:285-305. 2011
    ..cruzi. This review addresses the differentiation and major stage-specific antigens of T. cruzi and attempts to describe the complexity of the parasite and of the disease it causes...
  28. ncbi A Plasmodium berghei reference line that constitutively expresses GFP at a high level throughout the complete life cycle
    Blandine Franke-Fayard
    Department of Parasitology, Leiden University Medical Centre, Postbus 9600 RC, The Netherlands
    Mol Biochem Parasitol 137:23-33. 2004
    ..With the recent development of a second, independent selectable marker in P. berghei, PbGFPCON is a useful tool to investigate the effect of further genetic modifications on host-parasite interactions...
  29. ncbi Evolution of complex life cycles in helminth parasites
    Geoff A Parker
    Population and Evolutionary Biology Research Group, School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, UK
    Nature 425:480-4. 2003
    ..These two processes should also apply in helminths with penetrative infective stages, although the mathematical conditions differ...
  30. ncbi Whole-genome comparative RNA expression profiling of axenic and intracellular amastigote forms of Leishmania infantum
    Annie Rochette
    Research Centre in Infectious Disease, CHUL Research Centre, Quebec, Canada G1V 4G2
    Mol Biochem Parasitol 165:32-47. 2009
    ..These findings highlight the importance of the host macrophage in driving the parasite to specific adaptations, which consequently result in highly regulated changes in gene expression...
  31. ncbi Basic cell biology of Trypanosoma cruzi
    Wanderley de Souza
    Laboratorio de Ultraestrutura Celular Hertha Meyer, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Ilha do Fundao, Rio de Janeiro, Brasil
    Curr Pharm Des 8:269-85. 2002
    ....
  32. pmc Gene network landscape of the ciliate Tetrahymena thermophila
    Jie Xiong
    Key Laboratory of Aquatic Biodiversity and Conservation, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China
    PLoS ONE 6:e20124. 2011
    ..In this study, we used different methods to find gene networks in the ciliate Tetrahymena thermophila, and describe some important properties of this network, such as modules and hubs...
  33. ncbi A microplate assay for Leishmania amazonensis promastigotes expressing multimeric green fluorescent protein
    Marion Man Ying Chan
    Department of Microbiology and Immunology, Temple University School of Medicine, 3400 North Broad Street, Room 509 OMS, Philadelphia, PA 19140, USA
    Parasitol Res 89:266-71. 2003
    ..The method of expressing multimeric GFP for in vitro drug screening is likely to be extendable to many species of parasitic protozoa...
  34. pmc A conserved endocrine mechanism controls the formation of dauer and infective larvae in nematodes
    Akira Ogawa
    Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 37, D 72076 Tubingen, Germany
    Curr Biol 19:67-71. 2009
    ..Conservation of this small molecule ligand represents a fundamental link between dauer and infective larvae and might provide a general strategy for nematode parasitism...
  35. ncbi Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparum
    Paul R Gilson
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Mol Cell Proteomics 5:1286-99. 2006
    ..Together this work identified 11 and predicted a further 19 GPI-anchored proteins in P. falciparum...
  36. ncbi Trypanosoma cruzi: a stage-specific calpain-like protein is induced after various kinds of stress
    Viviane Giese
    Instituto Carlos Chagas Fiocruz, Curitiba, PR, Brasil
    Mem Inst Oswaldo Cruz 103:598-601. 2008
    ..We describe the characterization of a member of this family, which is differentially expressed during the life-cycle of Trypanosoma cruzi...
  37. ncbi Apicomplexan mitochondrial metabolism: a story of gains, losses and retentions
    Frank Seeber
    Molecular Parasitology, Institute for Biology, Humboldt University, Philippstr 13, 10115 Berlin, Germany
    Trends Parasitol 24:468-78. 2008
    ..Here, we compare the metabolic pathways of five Apicomplexans, focusing on their different mitochondrial functions, which highlight their adaptation to their individual intracellular habitats...
  38. ncbi Myxozoan genera: definition and notes on taxonomy, life-cycle terminology and pathogenic species
    Jiri Lom
    Institute of Parasitology, Academy of Sciences of the Czech Republic, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
    Folia Parasitol (Praha) 53:1-36. 2006
    ..Establishment of a classification acceptable from morphological, biological and phylogenetical viewpoints is necessary...
  39. pmc A cluster of ring stage-specific genes linked to a locus implicated in cytoadherence in Plasmodium falciparum codes for PEXEL-negative and PEXEL-positive proteins exported into the host cell
    Tobias Spielmann
    Infectious Diseases and Immunology Division, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston QLD 4029, Australia
    Mol Biol Cell 17:3613-24. 2006
    ..Biochemical and photobleaching studies using these proteins reveal new properties of the parasite-induced membrane compartments in the host cell. This has important implications for the biogenesis and connectivity of these structures...
  40. ncbi Recent advances in our knowledge of the Myxozoa
    M L Kent
    Department of Microbiology and Center for Salmon Disease Research, Oregon State University, Corvallis 97331 3804, USA
    J Eukaryot Microbiol 48:395-413. 2001
    ..Sphaerospora spp., and Myxidium leei cause disease in pen-reared sea bass (Dicentrarchus labrax) and sea bream species (family Sparidae) in Mediterranean countries...
  41. pmc The steady-state transcriptome of the four major life-cycle stages of Trypanosoma cruzi
    Todd A Minning
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602, USA
    BMC Genomics 10:370. 2009
    ..cruzi and related kinetoplastid parasites have suggested that the transcript abundances of most genes in these organisms do not vary significantly between life-cycle stages...
  42. ncbi Pathogenesis of bovine neosporosis
    J P Dubey
    Animal Parasitic Diseases Laboratory, United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, BARC East, Building 1001, 10300 Baltimore Avenue, Beltsville, MD 20705 2350, USA
    J Comp Pathol 134:267-89. 2006
    ..Defining these immunological mechanisms will shed light on potential methods of control of bovine neosporosis and enrich our understanding of the continuity of mammalian and protozoal survival...
  43. ncbi Stage-dependent production and release of histidine-rich protein 2 by Plasmodium falciparum
    Varunee Desakorn
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Trans R Soc Trop Med Hyg 99:517-24. 2005
    ..This assessment of the stage-dependent release of PfHRP2 is an essential prerequisite for future studies aimed at estimating the total patient parasite mass from the peripheral blood PfHRP2 concentration...
  44. ncbi Invasion of MDCK epithelial cells with altered expression of Rho GTPases by Trypanosoma cruzi amastigotes and metacyclic trypomastigotes of strains from the two major phylogenetic lineages
    Adriana B Fernandes
    Departamento de Microbiologia, Immunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de Sao Paulo UNIFESP, Rua Botucatu, 862 6th floor, 04023 062, Sao Paulo, SP, Brazil
    Microbes Infect 6:460-7. 2004
    ..The fact that in Rac1N17 dominant-negative cells, the invasion of G strain extracellular amastigotes was specifically inhibited suggested an important role for Rac1 in this process...
  45. pmc Signal transduction regulates schistosome reproductive biology
    Philip T LoVerde
    Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Curr Opin Microbiol 12:422-8. 2009
    ..Recent data have demonstrated that the pairing process, proliferation, and differentiation of vitelline cells, expression of female-specific genes and egg embryogenesis are regulated by the TGFbeta pathway and protein tyrosine kinases...
  46. pmc Activation of endocytosis as an adaptation to the mammalian host by trypanosomes
    Senthil Kumar A Natesan
    The Molteno Building, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, United Kingdom
    Eukaryot Cell 6:2029-37. 2007
    ..These data suggest that high-level endocytosis in Trypanosoma brucei is an adaptation required for viability in the mammalian host...
  47. ncbi Chemosensory proteins in the honey bee: Insights from the annotated genome, comparative analyses and expressional profiling
    Sylvain Foret
    ARC Centre for the Molecular Genetics of Development, Visual Sciences, The Australian National University, Canberra, ACT 0200, Australia
    Insect Biochem Mol Biol 37:19-28. 2007
    ..Some CSPs may function in cuticle synthesis, consistent with their evolutionary origins in the arthropods...
  48. ncbi Elucidating the transcriptome of Fasciola hepatica - a key to fundamental and biotechnological discoveries for a neglected parasite
    Neil D Young
    Department of Veterinary Science, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia
    Biotechnol Adv 28:222-31. 2010
    ....
  49. pmc Toxoplasma gondii: 25 years and 25 major advances for the field
    John C Boothroyd
    Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305 5124, USA
    Int J Parasitol 39:935-46. 2009
    ..Despite this, it is hoped that the reader will agree with, or at least not disagree too strongly with, most of the choices presented here...
  50. pmc Mechanisms of suspended animation are revealed by transcript profiling of diapause in the flesh fly
    Gregory J Ragland
    Department of Entomology and Nemtaology, University of Florida, Gainesville, FL 32611 0620, USA
    Proc Natl Acad Sci U S A 107:14909-14. 2010
    ....
  51. ncbi Effects of the synthetic estrogen 17 alpha-ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas)
    R Lange
    Experimental Toxikologie, Schering AG Research Laboratories, D 13342 Berlin, Germany
    Environ Toxicol Chem 20:1216-27. 2001
    ..A lack of sexual differentiation occurred in males at concentrations > or = 4.0 ng/L. Taking into account these data, the overall no-observed-adverse-effect concentration was considered to be 1.0 ng/L...
  52. ncbi Development of tolerance against toxic Microcystis aeruginosa in three cladocerans and the ecological implications
    Nichun Guo
    Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7, Wuhan 430072, PR China
    Environ Pollut 143:513-8. 2006
    ..This may explain why dominant Daphnia is usually replaced by small-sized cladocerans when cyanobacteria bloomed in summer in eutrophic lakes...
  53. ncbi Selective di- or trimethylation of histone H3 lysine 76 by two DOT1 homologs is important for cell cycle regulation in Trypanosoma brucei
    Christian J Janzen
    Laboratory of Molecular Parasitology, The Rockefeller University, New York, New York 10021, USA
    Mol Cell 23:497-507. 2006
    ..We propose that DOT1A and DOT1B influence the trypanosome cell cycle by regulating the degree of H3K76 methylation...
  54. pmc Malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria
    Wendy Prudhomme O'Meara
    Fogarty International Center, NIH, Bethesda, Maryland, USA
    Malar J 6:36. 2007
    ..This analysis evaluates the impact of diagnostic error, particularly that introduced by microscopy, on the outcome of efficacy trials of malaria vaccines and make recommendations for improving future trials...
  55. pmc Proteomic analysis of zygote and ookinete stages of the avian malaria parasite Plasmodium gallinaceum delineates the homologous proteomes of the lethal human malaria parasite Plasmodium falciparum
    Kailash P Patra
    Department of Medicine, George Palade Laboratories, University of California San Diego, CA 92093, USA
    Proteomics 8:2492-9. 2008
    ..falciparum. The results underpin more robust study of Plasmodium-mosquito midgut interactions, fundamental to the development of novel strategies of blocking malaria transmission...
  56. ncbi Clonorchiasis: a key foodborne zoonosis in China
    Zhao Rong Lun
    Center for Parasitic Organisms and the Key Laboratory for Tropical Diseases Control of the Ministry of Education, School of Life Sciences, Zhongshan Sun Yat Sen University, Guangzhou, China
    Lancet Infect Dis 5:31-41. 2005
    ....
  57. ncbi Sex in Plasmodium: a sign of commitment
    Matthew W A Dixon
    Malaria Biology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland 4006, Australia
    Trends Parasitol 24:168-75. 2008
    ..In this review, we outline the underlying mechanisms involved in this process, focusing on the transition between the asexual and the sexual blood-stages of the parasite...
  58. ncbi The immunobiology of schistosomiasis
    Edward J Pearce
    Department of Pathobiology, University of Pennsylvania, Philadelphia, Philadelphia 19104 6008, USA
    Nat Rev Immunol 2:499-511. 2002
    ..Here, we attempt to summarize advances in our understanding of the immunology of schistosomiasis, with the bulk of the review reflecting the experimental focus on Schistosoma mansoni infection in mice...
  59. ncbi Proteomic analysis of metacyclic trypomastigotes undergoing Trypanosoma cruzi metacyclogenesis
    A Parodi-Talice
    Institut Pasteur de Montevideo, Uruguay
    J Mass Spectrom 42:1422-32. 2007
    ..The identification and molecular characterization of these proteins will render vital information about the steps of the parasite differentiation into the infective form...
  60. pmc Sand flies and Leishmania: specific versus permissive vectors
    Petr Volf
    Trends Parasitol 23:91-2. 2007
  61. pmc Stage-specific immune responses in human Necator americanus infection
    S M Geiger
    Fundacao Oswaldo Cruz, Centro de Pesquisas Rene Rachou, Belo Horizonte MG, Brazil
    Parasite Immunol 29:347-58. 2007
    ..We propose that the longevity of hookworms in their human hosts results from a stage-specific, down-modulation of the immune response...
  62. pmc Comparative ribosome profiling reveals extensive translational complexity in different Trypanosoma brucei life cycle stages
    Juan José Vasquez
    Research Center for Infectious Diseases, University of Wuerzburg, Wuerzburg 97080, Germany, Département Biologie Cellulaire et Infection, Institut Pasteur, Unité Biologie Cellulaire du Parasitisme, Paris 75015, France, INSERM U786, Paris 75015, France and Rudolf Virchow Center, University of Wuerzburg, Wuerzburg 97080, Germany
    Nucleic Acids Res 42:3623-37. 2014
    ..We find that the latter varies greatly between life cycle stages of the parasite and ∼100-fold between genes, thus contributing to gene expression to a similar extent as ..
  63. ncbi The life cycle of Hyalomma rufipes (Acari: Ixodidae) under laboratory conditions
    Ze Chen
    State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Key Laboratory of Grazing Animal Diseases MOA, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Lanzhou, 730046, Gansu, China
    Exp Appl Acarol 56:85-92. 2012
    ..63 and 7.22, respectively. Engorged nymphs moulting to females were significantly heavier (27.6 ± 0.89 mg) than those moulting to males (22.3 ± 0.52 mg). Males outnumbered females by 1.4:1...
  64. ncbi Apoptosis phenomenon in the schistosomulum and adult worm life cycle stages of Schistosoma japonicum
    Hongxiao Han
    College of Veterinary Medicine, Yangzhou University, 12 East Wenhui Road, Yangzhou, Jiangsu, China
    Parasitol Int 62:100-8. 2013
    ..The data presented here demonstrates that apoptosis is an important biological process for the survival and development of the schistosome, and identifies potential novel therapeutic targets...
  65. pmc Plasmodium falciparum dynein light chain 1 interacts with actin/myosin during blood stage development
    Wassim Daher
    Unité INSERM 547 and Center for Infection and Immunity of Lille INSERM U1019, CNRS UMR 8204, Universite Lille Nord de France, Institut Pasteur de Lille, 1 rue du Prof Calmette, 59019 Lille, France
    J Biol Chem 285:20180-91. 2010
    ..Taken together, these findings suggest that PfDLC1 might play an important role in P. falciparum erythrocytic stages by its interaction with myosin A and actin 1, known to be essential for parasite development...
  66. ncbi Complex life cycles and the responses of insects to climate change
    Joel G Kingsolver
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Integr Comp Biol 51:719-32. 2011
    ..This suggests that considering the differing responses of multiple life stages is essential to understand the ecological and evolutionary consequences of climate change...
  67. ncbi Chalimus stages of Caligus latigenitalis (Copepoda:Caligidae) parasitic on blackhead seabream from Japanese waters, with discussion of terminology used for developmental stages of caligids
    Ione Madinabeitia
    Graduate School of Biosphere Science, Hiroshima University, 1 4 4 Kagamiyama, Higashi Hiroshima, Hiroshima, 937 8528 Japan
    J Parasitol 97:221-36. 2011
    ..New terminology for the developmental stages of caligid copepods is proposed herein by amending the definition of chalimus as the postnaupliar stages, as well as semaphoronts having a frontal filament for host attachment...
  68. ncbi Flow cytometric assessment of Leishmania spp metacyclic differentiation: validation by morphological features and specific markers
    Elvira M Saraiva
    Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Exp Parasitol 110:39-47. 2005
    ..The method here described can be applied to the identification of metacyclics of different Leishmania spp within the whole stationary population...
  69. pmc Microarray analyses of gene expression during the Tetrahymena thermophila life cycle
    Wei Miao
    Department of Biology, University of Rochester, Rochester, New York, USA
    PLoS ONE 4:e4429. 2009
    ..The model eukaryote, Tetrahymena thermophila, is the first ciliated protozoan whose genome has been sequenced, enabling genome-wide analysis of gene expression...
  70. ncbi Morphological evidence for proliferative regeneration of the Anopheles stephensi midgut epithelium following Plasmodium falciparum ookinete invasion
    L A Baton
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Biomedical Research Centre, 120 University Avenue, University of Glasgow, Glasgow G12 8TA, UK
    J Invertebr Pathol 96:244-54. 2007
    ..The loss of invaded midgut epithelial cells associated with intracellular migration by ookinetes, therefore, appears to trigger, and to be compensated by, proliferative regeneration of the mosquito midgut epithelium...
  71. ncbi Each life stage matters: the importance of assessing the response to climate change over the complete life cycle in butterflies
    Viktoriia Radchuk
    Biodiversity Research Centre, Earth and Life Institute, Universite Catholique de Louvain, Place Croix du Sud, 4, L7 07 04, 1348, Louvain la Neuve, Belgium
    J Anim Ecol 82:275-85. 2013
    ..Life stages that are cryptic or difficult to study should not be forsaken as they may be key determinants in the overall response to climate change, as we found with overwintering Boloria eunomia larvae...
  72. ncbi Expression of antimicrobial peptide genes in Bombyx mori gut modulated by oral bacterial infection and development
    Shan Wu
    Zhejiang Entry Exit Inspection and Quarantine Bureau, 2 Wen San Road, Hangzhou 310012, People s Republic of China
    Dev Comp Immunol 34:1191-8. 2010
    ..Our results imply that the immune responses in the silkworm gut are synergistically regulated by the Toll, JAK/STAT and IMD pathways. However, as the time for approaching pupation, the Toll pathway may play a role in the AMPs expression...
  73. ncbi Ophryoglena hemophaga n. sp. (Ciliophora: Ophryoglenidae): a parasite of the digestive gland of zebra mussels Dreissena polymorpha
    Daniel P Molloy
    New York State Museum, The State Education Department, Cultural Education Center, Albany, New York 12230, USA
    Dis Aquat Organ 65:237-43. 2005
    ..Protomonts and theronts are, respectively, negatively and positively phototactic--characteristics that likely aid in maintenance of infection in zebra mussel populations...
  74. ncbi Spreading the seeds of million-murdering death: metamorphoses of malaria in the mosquito
    Luke A Baton
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, UK, G12 8QQ
    Trends Parasitol 21:573-80. 2005
    ..Despite the intricacies inherent in these successive transformations, malaria parasites remain staggeringly successful at disseminating through their vertebrate host populations...
  75. pmc The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony
    Helen M Taylor
    Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow, United Kingdom
    Eukaryot Cell 9:37-45. 2010
    ....
  76. ncbi [Host-parasite relationships of the genus Hyalomma Koch, 1844 (Acari, Ixodidae) and their connection with microevolutionary process]
    D A Apanaskevich
    Parazitologiia 38:515-23. 2004
    ..In the second group, the immature stages as well as the adult stage parasitize large mammals. This group includes: H. dromedarii, H. anatolicum, and H. scupense. These species are two- or one-host ticks...
  77. ncbi Stage structure alters how complexity affects stability of ecological networks
    V H W Rudolf
    Department of Ecology and Evolutionary Biology, Rice University, Houston, TX, USA
    Ecol Lett 14:75-9. 2011
    ..These results suggest that natural communities are more vulnerable to biodiversity loss than indicated by previous analyses...
  78. ncbi Characterization of thyroid hormones and thyroid hormone receptors during the early development of Pacific bluefin tuna (Thunnus orientalis)
    Yutaka Kawakami
    Department of Fisheries, Graduate School of Agriculture, Kinki University, Nara 631 8505, Japan
    Gen Comp Endocrinol 155:597-606. 2008
    ..It is possible that thyroid hormones control the early development of scombrid fish through TRs, as they do for Pluronectiformes and Anguilliformes...
  79. ncbi Effects of aqueous exposure to silver nanoparticles of different sizes in rainbow trout
    Tessa M Scown
    Ecotoxicology and Aquatic Biology Research Group, Hatherly Laboratories, School of Biosciences, University of Exeter, Exeter EX4 4PS, UK
    Toxicol Sci 115:521-34. 2010
    ..However, exposure to N(10) particles was found to induce expression of cyp1a2 in the gills, suggesting a possible increase in oxidative metabolism in this tissue...
  80. pmc Structures of Toxoplasma gondii tachyzoites, bradyzoites, and sporozoites and biology and development of tissue cysts
    J P Dubey
    Parasite Biology and Epidemiology Laboratory, USDA Agricultural Research Service, Beltsville, Maryland 20705 2350, USA
    Clin Microbiol Rev 11:267-99. 1998
    ..The mechanism of in vivo and in vitro stage conversion from sporozoites to tachyzoites to bradyzoites and from bradyzoites to tachyzoites to bradyzoites is also discussed...
  81. ncbi Consequences for Protaphorura armata (Collembola: Onychiuridae) following exposure to genetically modified Bacillus thuringiensis (Bt) maize and non-Bt maize
    Lars Henrik Heckmann
    National Environmental Research Institute, Department of Terrestrial Ecology, Vejlsøvej 25, PO Box 314, DK 8600 Silkeborg, Denmark
    Environ Pollut 142:212-6. 2006
    ..Although there were no negative effects of Bt maize in this experiment, we recommend future studies on Bt crops to focus on species interactions in long-term, multi-species experiments...
  82. ncbi The life cycle and host specificity of Psychodiella sergenti n. sp. and Ps. tobbi n. sp. (Protozoa: Apicomplexa) in sand flies Phlebotomus sergenti and Ph. tobbi (Diptera: Psychodidae)
    Lucie Lantová
    Department of Parasitology, Charles University in Prague, Czech Republic
    J Invertebr Pathol 105:182-9. 2010
    ..Both gregarines are considered as serious pathogens in laboratory-reared colonies of Old World sand flies...
  83. ncbi Environmentally sensitive life-cycle traits have low elasticity: implications for theory and practice
    Valery E Forbes
    Department of Environmental, Social and Spatial Change, Roskilde University, Universitetsvej 1, P O Box 260, 4000 Roskilde, Denmark
    Ecol Appl 20:1449-55. 2010
    ..Better knowledge of these relationships can be used to optimize population management and protection strategies and to increase understanding of the drivers of population dynamics...
  84. ncbi Sporogony of Tetracapsuloides bryosalmonae in the brown trout Salmo trutta and the role of the tertiary cell during the vertebrate phase of myxozoan life cycles
    D J Morris
    Institute of Aquaculture, University of Stirling, Stirling FK9 4LA, Scotland, UK
    Parasitology 135:1075-92. 2008
    ..Taken in conjunction with existing phylogenetic data, 5 distinct sporogonial sequences are identified for the Myxozoa...
  85. ncbi New medicines to improve control and contribute to the eradication of malaria
    Timothy N C Wells
    Medicines for Malaria Venture, 20 Route de Pré Bois, 1215 Geneva, Switzerland
    Nat Rev Drug Discov 8:879-91. 2009
    ....
  86. ncbi Leishmania invasion and phagosome biogenesis
    Robert Lodge
    INRS Institut Armand Frappier, 531, boul des Prairies, Laval, Quebec H7V 1B7, Canada
    Subcell Biochem 47:174-81. 2008
    ..Here, we review recent evidence that L. donovani promastigotes subvert host macrophage actin dynamics during the establishment of infection and we discuss the potential mechanisms involved...
  87. pmc Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern
    Johannes Eckert
    Institute of Parasitology, University of Zurich, CH 8057 Zurich, Switzerland
    Clin Microbiol Rev 17:107-35. 2004
    ..Recent data have shown that this control option may be used in restricted areas, for example in cities, with the aim of reducing the infection risk for humans...
  88. pmc Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis
    Nicholas S Sokol
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Genes Dev 22:1591-6. 2008
    ..This heterochronic role of let-7 is likely just one of the ways in which let-7-C promotes adult behavior...
  89. ncbi Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution?
    Amy E Pasquinelli
    Molecular Biology Section, Division of Biology 0368, University of California, San Diego, 9500 Gilman Drive, Bonner Hall, Room 2214, La Jolla, CA 92093 0368, USA
    Evol Dev 5:372-8. 2003
    ..We argue that let-7 is not a bilaterian or triploblast synapomorphy but instead evolved later in metazoan evolution, perhaps in association with complex life history traits...
  90. ncbi Targeting of a tetracycline-inducible expression system to the transcriptionally silent minichromosomes of Trypanosoma brucei
    Bill Wickstead
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Mol Biochem Parasitol 125:211-6. 2002
  91. ncbi Squalene synthase as a chemotherapeutic target in Trypanosoma cruzi and Leishmania mexicana
    Julio A Urbina
    Laboratorio de Quimica Biologica, Centro de Bioquimica y Biofisica, Instituto Venezolano de Investigaciones Cientificas, Caracas 1020, Venezuela
    Mol Biochem Parasitol 125:35-45. 2002
    ..Taken together, these results support the notion that SQS inhibitors could be developed as selective anti-trypanosomatid agents...
  92. ncbi The polychaete Platynereis dumerilii (Annelida): a laboratory animal with spiralian cleavage, lifelong segment proliferation and a mixed benthic/pelagic life cycle
    Albrecht Fischer
    Institute of Zoology, University of Mainz, Germany
    Bioessays 26:314-25. 2004
    ..Platynereis can also become a stepping stone in the comparison of segmentation between annelids and arthropods because it comes closer to the putative ancestral morphology and style of development than other model annelids...
  93. ncbi Development, survivorship, and reproduction of Helicoverpa armigera (Lepidoptera: Noctuidae) under constant and alternating temperatures
    G K Mironidis
    Aristotle University of Thessaloniki, Faculty of Agriculture, Laboratory of Applied Zoology and Parasitology, 54124 Thessaloniki, Greece
    Environ Entomol 37:16-28. 2008
    ..5 degrees C, at both the constant and the corresponding alternating temperature regimes (0.147 and 0.139, respectively). Extreme temperatures had a negative effect on life table parameters...
  94. ncbi Transcriptomics throughout the life cycle of Leishmania infantum: high down-regulation rate in the amastigote stage
    Pedro J Alcolea
    Departamento de Microbiología Molecular y Biología de las Infecciones, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
    Int J Parasitol 40:1497-516. 2010
    ..These findings are consistent with the hypothesis of pre-adaptation of the parasite to intracellular survival at this stage...
  95. ncbi Morphology and ultrastructure of multiple life cycle stages of the photosynthetic relative of apicomplexa, Chromera velia
    Miroslav Obornik
    Biology Centre, Institute of Parasitology, Czech Academy of Sciences, and Faculty of Science, University of South Bohemia, 37005 České Budějovice Budweis, Czech Republic
    Protist 162:115-30. 2011
    ..Ultrastructural analysis of the flagellate supports its close association with colpodellids and apicomplexans and provides important insight into their evolution...
  96. ncbi Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility
    Nobutaka Kato
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, ICND202 La Jolla, California 92037, USA
    Nat Chem Biol 4:347-56. 2008
    ..falciparum and a large reduction in intracellular parasites in Toxoplasma gondii, which suggests a possible role for PfCDPK1 in regulation of parasite motility during egress and invasion...
  97. pmc Critical role of a K+ channel in Plasmodium berghei transmission revealed by targeted gene disruption
    Peter Ellekvist
    Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, DK 2200 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 105:6398-402. 2008
    ..berghei parasites and supports the growth of the parasites, in particular the development of oocysts in the mosquito midgut. K(+) channels therefore may constitute a potential antimalarial drug target...
  98. ncbi The Schistosoma mansoni soluble proteome: a comparison across four life-cycle stages
    Rachel S Curwen
    Department of Biology, University of York, Heslington, York YO10 5DD, UK
    Mol Biochem Parasitol 138:57-66. 2004
    ..Equally, it is difficult to reconcile the abundance and immunogenicity of such cytosolic proteins with their status as vaccine candidates, as it is unlikely they will be accessible to the immune system in an intact parasite...
  99. pmc Developmental gene expression profiles of the human pathogen Schistosoma japonicum
    Geoffrey N Gobert
    Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    BMC Genomics 10:128. 2009
    ..Advanced analyses including ANOVA, principal component analysis, and hierarchal clustering provided a global synopsis of gene expression relationships among the different developmental stages of the schistosome parasite...
  100. pmc The developmental cell biology of Trypanosoma brucei
    Keith R Matthews
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK
    J Cell Sci 118:283-90. 2005
    ..genome, flagellum and associated basal body provide the classical descriptions of the different life cycle stages of the parasite...
  101. ncbi The distribution of motor proteins in the muscles and flame cells of the Schistosoma mansoni miracidium and primary sporocyst
    D Bahia
    Laboratório de Parasitologia Celular e Molecular, Centro de Pesquisas Rene Rachou Fiocruz, Av Augusto de Lima 1715, 30190 002, Belo Horizonte, MG, Brazil
    Parasitology 133:321-9. 2006
    ..The additional presence of myosin in these tubules strongly suggests that they are contractile structures...

Research Grants62

  1. Understanding the biology of schistosomes in response to praziquantel
    Charles Cunningham; Fiscal Year: 2013
    ..We also propose to exploit the fact that different life cycle stages of S...
  2. Role of mucin-type O-glycosylation in Trypanosoma cruzi biology
    Christopher M West; Fiscal Year: 2012
    ..cruzi, and expression of the TcOGNTs will be mapped over serial life cycle stages. The genetically modified parasites will be used to evaluate defects in glycosylation, enzyme activities and ..
  3. Purine Salvage Pathway of Cryptosporidium Parvum
    Buddy Ullman; Fiscal Year: 2012
    ..parvum parasites will be ascertained throughout biologically accessible life cycle stages. Finally, structure-function studies based upon a molecular model of CpAK will test the roles of key ..
  4. Immunopathology of the Pneumocystis Life Cycle Stages
    Melanie T Cushion; Fiscal Year: 2013
    ..murina cysts in the deleterious pulmonary hyperinflammatory response following immune reconstitution by evaluating cytokine and cellular profiles in the lungs of cyst replete and cyst depleted populations of P. murina. ..
  5. Transcriptome profiling of Trypanosoma cruzi and its host cell
    Najib M El-Sayed; Fiscal Year: 2012
    ..Using a suite of algorithms, mRNA abundance will be determined for every T. cruzi gene in each of four life cycle stages enabling us to identify co-expression patterns that correlate with the biology of the parasite...
  6. Deep sequence profiling of gRNA transcriptomes in two stages of Trypanosoma bruce
    DONNA JAY KOSLOWSKY; Fiscal Year: 2012
    ..is to utilize deep sequencing technology to characterize the full gRNA transcriptomes in the two main life cycle stages of Trypanosoma brucei...
  7. Biochemical and Functional Analysis of Trypanin
    Kent L Hill; Fiscal Year: 2013
    ..Trypanosomes are highly motile in both life cycle stages and motility is central to parasite development and disease pathogenesis...
  8. Targeting Entry Pathways in Leishmaniasis
    DAWN MARIE WETZEL; Fiscal Year: 2013
    ..Leishmania must live inside phagocytes to survive. Both life cycle stages, promastigotes and amastigotes, infect macrophages...
  9. Role of the guide RNA binding protein RBP16 in the bloodstream form of T. brucei
    John C Fisk; Fiscal Year: 2010
    ..process in both the procyclic insect vector stage (PF) and the bloodstream mammalian host stage (BF) life cycle stages. Thus, proteins involved in RNA editing are promising targets for chemotherapeutic attack...
  10. New infection-related proteins of Plasmodium sporozoites and liver stages
    Stefan H I Kappe; Fiscal Year: 2013
    ..Liver stages remain the least understood of all malaria life cycle stages and have only recently become amenable to systematic, detailed study...
  11. Cis- and trans-acting factors in mitochondrial RNA decay
    Laurie K Read; Fiscal Year: 2012
    ..Nevertheless, levels of mature monocistronic RNAs vary dramatically between life cycle stages. This indicates that steady-state RNA abundance, and thus gene expression, is controlled by ..
  12. Fundamental Aspects of Kinetoplastid Mitochondrial RNA Stability
    Sara Lana Zimmer; Fiscal Year: 2013
    ..be the reason for the varied mitochondrial transcript abundances observed between the insect and mammalian life cycle stages of the parasite...
  13. Biology of the Apicomplexan Plastid
    Boris Striepen; Fiscal Year: 2013
    ..A detailed understanding of the biology of this structure will lead us to new parasite specific interventions to treat and prevent disease. ..
  14. New molecular techniques for T. cruzi
    Huan Huang; Fiscal Year: 2013
    ..cruzi life cycle stages. Using this technique, we found that two mitogen activated protein kinases (MAPK), TcMAPK1 and TcMAPK3, are ..
  15. Understanding the biology of schistosomes in response to praziquantel
    Charles Cunningham; Fiscal Year: 2010
    ..We will exploit the fact that different life cycle stages of Schistosoma mansoni have differing susceptibilities to PZQ by employing microarrays to analyze the ..
  16. Plasmodium cynomolgi as a model for P. vivax.
    Mary R Galinski; Fiscal Year: 2012
    ..fluorescent tags, as the first step for future studies aiming to identify, purify and investigate specific life cycle stages, with a primary interest at this time on the development and activation of the elusive hypnozoite stage...
  17. MITOCHONDRIAL DNA OF NORMAL AND MUTANT TRYPANOSOMES
    Kenneth D Stuart; Fiscal Year: 2013
    ..that precisely edit mt mRNAs in Trypanosoma brucei and its regulation and differential editing between life cycle stages. It examines the editosome endonuclease subcomplex which discriminates among thousands of editing sites (ESs)..
  18. Optimizing ELQs for Treatment and Prevention of Malaria
    MICHAEL KEVIN RISCOE; Fiscal Year: 2012
    ..by us and others) have shown that the Endochin-like Quinolone (ELQ) chemotype targets all 3 of these life cycle stages. The ultimate objective of our proposed work is the development of an inexpensive ELQ that can be co-..
  19. RAPD MARKERS FOR HELMINTHS
    Steven Nadler; Fiscal Year: 1993
    ..include: characterization and identification of strains; genome mapping; identification of conspecific life cycle stages; assessing levels of gene flow/genetic differentiation among populations; and identification of cryptic ..
  20. LYMPHATIC LESION PATHOGENESIS IN BRUGIA-INFECTED JIRDS
    THOMAS KLEI; Fiscal Year: 1991
    ..Specific Aim 2 is to identify the parasite life cycle stages and factors responsible for the decreased inflammatory responses seen during chronic infections...
  21. MITOCHONDRIAL RNA METABOLISM IN TRYPANOSOMA BRUCEI
    LAURIE READ; Fiscal Year: 2004
    ..Nevertheless, levels of mature monocistronic RNAs vary dramatically between life cycle stages. This indicates that steady-state RNA abundance, and thus gene expression, is controlled by ..
  22. MITOCHONDRIAL RNA METABOLISM IN TRYPANOSOMA BRUCEI
    LAURIE READ; Fiscal Year: 2007
    ..Nevertheless, levels of mature monocistronic RNAs vary dramatically between life cycle stages. This indicates that steady-state RNA abundance, and thus gene expression, is controlled by ..
  23. Ribosomes of Plasmodium falciparum
    JEAN FEAGIN; Fiscal Year: 2006
    ..Also, some drugs inhibit parasite growth differentially between life cycle stages and inhibition with some drugs is delayed...
  24. Phosphodiesterase Function and Activity in Plasmodium Falciparum
    Paul Pottinger; Fiscal Year: 2007
    ..expression levels of all four PDEs with quantitative PCR of each PDE on mRNA harvested from different life cycle stages, and with Western blotting of protein lysates from different life-cycle stages with antibodies mono-specific ..
  25. PLASMEPSINS AS ANTIMALARIAL DRUG TARGETS
    John Dame; Fiscal Year: 1999
    ..b>Life cycle stages found in the mosquito vector will also be examined by immunoelectron microscopy for the presence of ..
  26. T. brucei Mitochondrial Proteome
    Kenneth Stuart; Fiscal Year: 2009
    ..will characterize the mitochondrial (mt) proteome of Trypanosoma brucei, and protein differences between life cycle stages. It will elucidate the functions of potentially all mt proteins and construct structural and functional ..
  27. MITOCHONDRIAL GENES OF PLASMODIUM FALCIPARUM
    JEAN FEAGIN; Fiscal Year: 1992
    ..expressed, and cytochrome c oxidase I and the mitochondrial rRNAs, which are likely to be expressed in all life cycle stages. The general characteristics of the transcripts of specific mitochondrial genes will be investigated and ..
  28. Biogenesis of the T. brucei Mitochondrial ATP Synthase
    Noreen Williams; Fiscal Year: 2006
    ..to produce mitochondrial complexes and will provide insight into the significance of the ATP synthase in all life cycle stages of T. brucei...
  29. CHARACTERIZATION OF A TRYPANSOMA BRUCEI PROTEASE
    Eric Pamer; Fiscal Year: 1991
    ..The synthesis and turnover rates of the protease and its mRNA will be compared in the different life cycle stages and under varying degrees of polyamine depletion...
  30. Biochemical and Functional Analysis of Trypanin
    KENT HILL; Fiscal Year: 2007
    ..Trypanosomes are highly motile in both life cycle stages and motility is central to parasite development and disease pathogenesis...
  31. LEISHMANIA PROTON PUMP: GENES & PROTEINS
    James Stringer; Fiscal Year: 1992
    ..information will be used produce nucleic acid and antibody probes for the analysis of expression in the two life cycle stages of the parasite...
  32. MITOCHONDRIAL DNA OF NORMAL AND MUTANT TRYPANOSOMES
    Kenneth Stuart; Fiscal Year: 2001
    ..The in vivo translation of edited transcripts in different life cycle stages and the possibility that different proteins may be produced from the same gene depending on editing will be ..
  33. LIPIDS OF LEISHMANIAS AND TRYPANOSOMES
    John Lucas; Fiscal Year: 1992
    ....
  34. ASSET AND HEALTH DYNAMICS AMONG THE OLDEST OLD
    Robert Willis; Fiscal Year: 1999
    ....
  35. GENE DISCOVERY IN TOXOPLASMA GONDII
    L Sibley; Fiscal Year: 2003
    ..In combination with the genetic tools available in T. gondii, this will greatly accelerate investigations into the complex developmental biology of apicomplexan parasites. ..
  36. GENETIC DISSECTION OF TOXOPLASMA GONDII
    David Roos; Fiscal Year: 2008
    ..In addition to their value for the analysis of folate metabolism and drug resistance, these tools should be broadly applicable to other studies on the biology and biochemistry of Toxoplasma. ..
  37. Confocal Microscope for Microbiology
    L Sibley; Fiscal Year: 2002
    ..This instrument will greatly strengthen the research programs of these highly productive groups by applying high-resolution confocal microscopy to the study of human pathogens...
  38. Calcium ATPases in Apicomplexan Parasites as Potential D
    L Sibley; Fiscal Year: 2006
    ..Knowledge gained through these studies may improve the ability to pharmacologically inhibit key calcium regulatory enzymes and hence block motility and invasion by this important group of parasites. ..
  39. Mucosal Immunity to Toxoplasma gondii
    L Sibley; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  40. Effect of HIV-1 Vpr on Basic Cellular Functions (II)
    Richard Zhao; Fiscal Year: 2007
    ..abstract_text> ..
  41. MUTATOR TRANSPORTABLE ELEMENTS OF MAIZE
    Virginia Walbot; Fiscal Year: 2005
    ..Host factors that regulate MuDR/Mu activities will also be characterized, because transposable element activities are an evolved nartnershiD of the transDoson and its host. ..
  42. SCHISTOSOME EGG INDUCED TH2 RESPONSES
    Edward Pearce; Fiscal Year: 2007
    ..abstract_text> ..
  43. 2006 Environmental Endocrine Disruptors Gordon Conference
    Rex Hess; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  44. HTS Inhibitors:Schistosoma Mansoni Peroxiredoxins(RMI)
    David Williams; Fiscal Year: 2005
    ..This will be the first step in the development of novel antischistosome chemotherapies, which are essential for continued public health measures. ..
  45. Mechanisms of anti-schistosome artemisinin chemotherapy
    David Williams; Fiscal Year: 2006
    ..mansoni translationally controlled tumor protein. The critical conclusions of this study will direct subsequent future experiments into the molecular mechanism of artemisinin's anti-parasitic activity. ..
  46. Generation of babesial surface protein diversity
    SHAWN BERENS; Fiscal Year: 2006
    ..The sponsors collaborate closely in research and have successfully mentored clinicians, graduate students, and post-doctoral fellows to research independence. ..
  47. TRANSMISSION OF PNEUMOCYSTIS INFECTION
    Melanie Cushion; Fiscal Year: 2001
    ..These studies will result in a clearer understanding of the biology leading to infection with Pc and will provide a rational basis for clinical management and therapeutic intervention. ..
  48. Targeting Brain Macrophages by a novel lentiviral vector
    Yuntao Wu; Fiscal Year: 2006
    ..abstract_text> ..
  49. Eighth International Workshops on Opportunistic Protists
    Melanie Cushion; Fiscal Year: 2003
    ..Mead's and Cushion's ancestors include native Americans; Marciano-Cabral is Hispanic; Kaneshiro has Pacific-Asian ancestry; Lindsay, Weiss are white. Lindsay is a physically handicapped individual. ..
  50. SIGNAL TRANSDUCTION IN SCHISTOSOMES
    Philip Loverde; Fiscal Year: 2004
    ..We expect to identify useful targets for control of parasite development and/or parasite caused morbidity. ..
  51. POPULATION STRUCTURE OF SCHISTOSOMES AND HOST SNAILS
    DENNIS MINCHELLA; Fiscal Year: 2007
    ..abstract_text> ..
  52. IMMUNITY TO PARASITIC INFECTION
    Judith Appleton; Fiscal Year: 2008
    ..The work we propose will elucidate a potent mechanism of intestinal immunity and will improve our ability to develop novel vaccines for intestinal pathogens. ..
  53. A Novel Virus that Infects & Sterilizes Insect Vectors of Human Disease
    Drion Boucias; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  54. Forward Genetics in Tetrahymena: Cloning by Complementation
    ROBERT COYNE; Fiscal Year: 2008
    ..Numerous other basic studies with far-reaching relevance to human health would be facilitated by the availability of the proposed freely available resource. [unreadable] [unreadable] [unreadable] [unreadable]..
  55. Spiralian developmental system for the study of multipotency
    Cesar Arenas Mena; Fiscal Year: 2008
    ..The ultimate goal is to manipulate these genes and reprogram in vivo differentiated cells into multipotent stem cells. [unreadable] [unreadable] [unreadable]..
  56. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  57. Conference--Molecular Helminthology, Integrated Approach
    Philip Loverde; Fiscal Year: 2005
    ..Certainly there are fascinating scientific questions waiting to be answered about helminths. Some of those questions have as their central theme the very nature of parasitism. ..
  58. Regulation and function of cGMP in the nervous system
    David B Morton; Fiscal Year: 2011
    ..Viagra and other pharmacological treatments for erectile disfunction are probably just the tip of the iceberg for compounds that target cGMP mediated processes. ..
  59. Apolipoprotein E 4/4 protects against falciparum malaria
    Hisashi Fujioka; Fiscal Year: 2005
    ..These studies represent a unique approach in the battle against malaria and could provide the basis for the design of an entirely new class of anti-malarial drugs. ..
  60. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  61. Sterol Biosynthesis in Trypanosomatid Parasites
    Frederick Buckner; Fiscal Year: 2004
    ..The drugs discovered in this research program will hopefully provide better future treatment for patients with these devastating diseases. ..
  62. LYME DISEASE IN WESTERN USA: ECOLOGY AND EPIDEMIOLOGY
    Robert Lane; Fiscal Year: 2008
    ..Development of this risk model, which culminates over 2 decades of intensive study, should contribute significantly to our knowledge of the landscape ecology and epidemiology of LD in this region. ..