- How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)
Dept of Human Nutrition, Institute of Nutrition, University of Jena, Germany
Exp Gerontol 45:410-8. 2010
..in this review indicate that ROS are essential signaling molecules which are required to promote health and longevity. Hence, the concept of mitohormesis provides a common mechanistic denominator for the physiological effects of ..
- Oxidants, oxidative stress and the biology of ageing
Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute National Institutes of Health, Bethesda, Maryland 20892 1622, USA
Nature 408:239-47. 2000
..Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span...
- Extending healthy life span--from yeast to humans
Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
Science 328:321-6. 2010
..We discuss these findings and their potential application to prevention of age-related disease and promotion of healthy aging in humans, and the challenge of possible negative side effects...
- The genetics of ageing
Cynthia J Kenyon
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
Nature 464:504-12. 2010
..Which genes can extend lifespan? Can we augment their activities and live even longer? After centuries of wistful poetry and wild imagination, we are now getting answers, often unexpected ones, to these fundamental questions...
- Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Konrad T Howitz
BIOMOL Research Laboratories, Inc, 5120 Butler Pike, Plymouth Meeting, Pennsylvania 19462, USA
Nature 425:191-6. 2003
..We discuss possible evolutionary origins of this phenomenon and suggest new lines of research into the therapeutic use of sirtuin activators...
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
David E Harrison
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Nature 460:392-5. 2009
..These findings have implications for further development of interventions targeting mTOR for the treatment and prevention of age-related diseases...
- Caloric restriction delays disease onset and mortality in rhesus monkeys
Ricki J Colman
Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
Science 325:201-4. 2009
..Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species...
- Genetics of longevity in model organisms: debates and paradigm shifts
Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom
Annu Rev Physiol 75:621-44. 2013
..Here we reexamine central concepts about the nature of aging...
- Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
Dudley W Lamming
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Science 335:1638-43. 2012
..Thus, mTORC2 disruption is an important mediator of the effects of rapamycin in vivo...
- Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
Coleen T Murphy
Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2200, USA
Nature 424:277-83. 2003
- daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
K D Kimura
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Science 277:942-6. 1997
..Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity...
- The cell-non-autonomous nature of electron transport chain-mediated longevity
The Glenn Center for Aging Research, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Cell 144:79-91. 2011
..stress responses are essential and specific genetic requirements for the electron transport chain (ETC) longevity pathway...
- Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Cell 120:513-22. 2005
..Thus, the senescence response may be antagonistically pleiotropic, promoting early-life survival by curtailing the development of cancer but eventually limiting longevity as dysfunctional senescent cells accumulate.
- Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
Mech Ageing Dev 128:92-105. 2007
..Within this perspective, healthy aging and longevity are likely the result not only of a lower propensity to mount inflammatory responses but also of efficient anti-..
- Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
Joseph T Rodgers
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 434:113-8. 2005
..Thus, we have identified a molecular mechanism whereby SIRT1 functions in glucose homeostasis as a modulator of PGC-1alpha. These findings have strong implications for the basic pathways of energy homeostasis, diabetes and lifespan...
- Mitonuclear protein imbalance as a conserved longevity mechanism
Riekelt H Houtkooper
Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
Nature 497:451-7. 2013
b>Longevity is regulated by a network of closely linked metabolic systems...
- Recent progress in the biology and physiology of sirtuins
Translational Medicine Branch, National Heart Lung and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 460:587-91. 2009
..Here we review the recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long we live...
- FOXO transcription factors at the interface between longevity and tumor suppression
Eric L Greer
Department of Genetics, Stanford University, CA 94305, USA
Oncogene 24:7410-25. 2005
..FOXO transcription factors are promising candidates to serve as molecular links between longevity and tumor suppression. These factors are major substrates of the protein kinase Akt...
- Molecular evolution and functional characterization of Drosophila insulin-like peptides
Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom
PLoS Genet 6:e1000857. 2010
..insulin/IGF signaling (IIS) pathway plays key roles in growth, metabolism, stress resistance, reproduction, and longevity in diverse organisms including mammals...
- Extension of chronological life span in yeast by decreased TOR pathway signaling
R Wilson Powers
Department of Genome Sciences and Medicine, The Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
Genes Dev 20:174-84. 2006
..We propose that up-regulation of a highly conserved response to starvation-induced stress is important for life span extension by decreased TOR signaling in yeast and higher eukaryotes...
- Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, UK
Cell Metab 11:35-46. 2010
..Analysis of the underlying mechanisms revealed that rapamycin increased longevity specifically through the TORC1 branch of the TOR pathway, through alterations to both autophagy and translation...
- Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
Department of Biochemistry and Biophysics, University of California, 600 16th Street, San Francisco, CA 94158, USA
Aging Cell 6:95-110. 2007
..Our findings link TOR, but not sir-2.1, to the longevity response induced by dietary restriction (DR) in C...
- Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK
Nature 477:482-5. 2011
..In C. elegans, outcrossing of a line with high-level sir-2.1 overexpression abrogated the longevity increase, but did not abrogate sir-2.1 overexpression...
- A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine
Douglas C Wallace
Center for Molecular and Mitochondrial Medicine and Genetics, Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92697 3940, USA
Annu Rev Genet 39:359-407. 2005
..Therefore the mitochondria provide a direct link between our environment and our genes and the mtDNA variants that permitted our forbears to energetically adapt to their ancestral homes are influencing our health today...
- Extending life span by increasing oxidative stress
Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743 Jena, Germany
Free Radic Biol Med 51:327-36. 2011
..This review aims to summarize published evidence that several longevity-promoting interventions may converge by causing an activation of mitochondrial oxygen consumption to promote ..
- Regulation of aging and age-related disease by DAF-16 and heat-shock factor
Ao Lin Hsu
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2200, USA
Science 300:1142-5. 2003
..activate expression of specific genes, including genes encoding small heat-shock proteins, which in turn promote longevity. The small heat-shock proteins also delay the onset of polyglutamine-expansion protein aggregation, suggesting ..
- Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
H A Tissenbaum
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Nature 410:227-30. 2001
..factor (daf-16), which may regulate targets that promote dauer formation in larvae and stress resistance and longevity in adults...
- Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK
Science 326:140-4. 2009
..Our results demonstrate that S6K1 influences healthy mammalian life-span and suggest that therapeutic manipulation of S6K1 and AMPK might mimic CR and could provide broad protection against diseases of aging...
- Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
Jennifer M A Tullet
Section on Developmental and Stem Cell Biology, Joslin Diabetes Center Department of Pathology, Harvard Medical School Harvard Stem Cell Institute, 1 Joslin Place, Boston, MA 02215, USA
Cell 132:1025-38. 2008
..In C. elegans, reductions in IIS increase stress resistance and longevity, effects that require the IIS-inhibited FOXO protein DAF-16. The C...
- Mammalian sirtuins: biological insights and disease relevance
Marcia C Haigis
Glenn Laboratories for the Molecular Biology of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Annu Rev Pathol 5:253-95. 2010
..This review summarizes and discusses the advances of the past decade and the challenges that will confront the field in the coming years...
- RPN-6 determines C. elegans longevity under proteotoxic stress conditions
Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Nature 489:263-8. 2012
..elegans results in elevated somatic proteasome activity, clearance of damaged proteins and increased longevity. This activity is associated with increased expression of rpn-6, a subunit of the 19S proteasome, by the FOXO ..
- Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
Tim J Schulz
Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743 Jena, Germany
Cell Metab 6:280-93. 2007
- TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO
Joslin Diabetes Center, Harvard Stem Cell Institute, and Department of Genetics, Harvard Medical School, Boston, MA 02215, USA
Cell Metab 15:713-24. 2012
..elegans, SKN-1/Nrf, and DAF-16/FoxO activate protective genes, and increase stress resistance and longevity. SKN-1 also upregulates TORC1 pathway gene expression in a feedback loop...
- Induction of autophagy by spermidine promotes longevity
Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
Nat Cell Biol 11:1305-14. 2009
..Finally, we found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity.
- SIRT1 transgenic mice show phenotypes resembling calorie restriction
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Aging Cell 6:759-67. 2007
..Our findings suggest that increased expression of SIRT1 in mice elicits beneficial phenotypes that may be relevant to human health and longevity.
- Genome sequencing reveals insights into physiology and longevity of the naked mole rat
Eun Bae Kim
Department of Bioinspired Science, Ewha Womans University, Seoul, 120 750, Korea
Nature 479:223-7. 2011
..This information provides insights into the naked mole rat's exceptional longevity and ability to live in hostile conditions, in the dark and at low oxygen...
- Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans)
Mikhail V Blagosklonny
Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA
Cell Cycle 9:683-8. 2010
..Therefore in humans the effect of CR may be somewhat blunted. Still how much does CR extend human lifespan? And could this extension be surpassed by gerosuppressants such as rapamycin?..
- Lessons on longevity from budding yeast
Department of Pathology, University of Washington, Seattle, Washington 98195, USA
Nature 464:513-9. 2010
..Studies of budding yeast have made immense contributions to this progress. Yeast longevity factors have now been shown to modulate ageing in invertebrate and mammalian models, and studies of yeast have ..
- Rapamycin extends maximal lifespan in cancer-prone mice
Vladimir N Anisimov
Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, St Petersburg, Russia
Am J Pathol 176:2092-7. 2010
..Rapamycin dramatically delayed tumor onset as well as decreased the number of tumors per animal and tumor size. We suggest that, by slowing down organismal aging, rapamycin delays cancer...
- Suppression of aging in mice by the hormone Klotho
Department of Pathology, University of Texas UT Southwestern Medical Center at Dallas, 5323 Harry Hines Bouleuvard, Dallas, TX 75390 9072, USA
Science 309:1829-33. 2005
..Klotho protein may function as an anti-aging hormone in mammals...
- With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Cell Metab 11:453-65. 2010
- Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
Richard C Grandison
Institute of Healthy Ageing, Department of Genetics Evolution and Environment, University College London, UK
Nature 462:1061-4. 2009
..In other organisms, including mammals, it may be possible to obtain the benefits to lifespan of dietary restriction without incurring a reduction in fecundity, through a suitable balance of nutrients in the diet...
- A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
Maria K Lehtinen
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Cell 125:987-1001. 2006
..of the FOXO transcription factors as major and evolutionarily conserved targets of MST1 suggests that MST kinases play important roles in diverse biological processes including cellular responses to oxidative stress and longevity.
- FOXO3A genotype is strongly associated with human longevity
Bradley J Willcox
Pacific Health Research Institute, 846 South Hotel Street, Honolulu, HI 96813, USA
Proc Natl Acad Sci U S A 105:13987-92. 2008
Human longevity is a complex phenotype with a significant familial component, yet little is known about its genetic antecedents...
- The endocrine regulation of aging by insulin-like signals
Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
Science 299:1346-51. 2003
- Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan
Department of Biochemistry and Biophysics, Mission Bay Genentech Hall, 600 16th Street, Room S312D, University of California, San Francisco, San Francisco, CA 94143, USA
Cell 115:489-502. 2003
In C. elegans, the transcription factor DAF-16 promotes longevity in response to reduced insulin/IGF-1 signaling or germline ablation. In this study, we have asked how different tissues interact to specify the lifespan of the animal...
- Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
Richard A Miller
Department of Pathology, University of Michigan, Ann Arbor, MI 48109 2200, USA
J Gerontol A Biol Sci Med Sci 66:191-201. 2011
- Association of FOXO3A variation with human longevity confirmed in German centenarians
Institute of Clinical Molecular Biology, Institute of Medical Informatics and Statistics, and Popgen Biobank, Christian Albrechts University, 24105 Kiel, Germany
Proc Natl Acad Sci U S A 106:2700-5. 2009
..A recent study described 3 SNPs in the FOXO3A gene that were statistically significantly associated with longevity in a discovery sample of long-lived men of Japanese ancestry [Willcox et al...
- Extended longevity in mice lacking the insulin receptor in adipose tissue
Joslin Diabetes Center and Department of Medicine, Harvard Medical School, One Joslin Place, Boston, MA, 02215 USA
Science 299:572-4. 2003
Caloric restriction has been shown to increase longevity in organisms ranging from yeast to mammals...
- Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila
Institute of Healthy Ageing, Department of Genetics Evolution and Environment, University College London, London, United Kingdom
PLoS ONE 7:e47699. 2012
..We have investigated whether the longevity-promoting effects of metformin are evolutionarily conserved using the fruit fly, Drosophila melanogaster...
- Gene expression analysis of mTOR pathway: association with human longevity
Willemijn M Passtoors
Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Aging Cell 12:24-31. 2013
..been associated with human diseases such as diabetes and cancer, but has not been investigated for its impact on longevity per se...
- Genetic signatures of exceptional longevity in humans
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
PLoS ONE 7:e29848. 2012
Like most complex phenotypes, exceptional longevity is thought to reflect a combined influence of environmental (e.g., lifestyle choices, where we live) and genetic factors...
- Regulation of Drosophila lifespan by JNK signaling
Department of Biology, University of Rochester, Rochester, NY 14627, USA
Exp Gerontol 46:349-54. 2011
..Here, we review recent studies in Drosophila that elucidate the tissue-specific and systemic consequences of JNK activation that ultimately impact lifespan of the organism...
- Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity
Seung Jae Lee
Division of Molecular and Life Science, School of Interdisciplinary Bioscience and Bioengineering, and World Class University Information Technology Convergence Engineering, Pohang University of Science and Technology, Pohang, Kyungbuk 790 784, South Korea
Curr Biol 20:2131-6. 2010
..Thus, it is possible that mechanisms that sense oxygen play a role in the longevity response to reduced respiration...
- Autophagy genes are essential for dauer development and life-span extension in C. elegans
Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
Science 301:1387-91. 2003
..elegans orthologs of the yeast autophagy genes APG1, APG7, APG8, and AUT10. Thus, autophagy is a cellular pathway essential for dauer development and life-span extension in C. elegans...
- Lifespan regulation by evolutionarily conserved genes essential for viability
Sean P Curran
Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS Genet 3:e56. 2007
..Genes that are essential for growth and development are highly conserved in evolution, but their role in longevity has not previously been assessed...
- SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span
Tiara L A Kawahara
Program in Epithelial Biology, Division of Endocrinology, Gerontology, and Metabolism, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 136:62-74. 2009
Members of the sirtuin (SIRT) family of NAD-dependent deacetylases promote longevity in multiple organisms...
- Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
Genes Dev 21:3061-6. 2007
..Thus, normal levels of autophagy are crucial for stress survival and continuous cellular renewal, but not metamorphosis...
- Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA
Nat Genet 28:139-45. 2001
..Together these findings reveal unexpected complexity in the DAF-16-dependent pathways that regulate aging...
- Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal
Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany
Cell Metab 15:451-65. 2012
..Inhibition of this ROS signal by antioxidants reduces iIIS-mediated longevity by up to 60%...
- A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans
Department of Biology, McGill University, Montreal, Quebec, Canada
PLoS Biol 8:e1000556. 2010
..Partial loss-of-function mutations in these genes decrease electron transport and greatly increase the longevity of C. elegans by a mechanism that is distinct from that induced by reducing their level of expression by RNAi...
- Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
Kevin J Pearson
Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Cell Metab 8:157-68. 2008
..Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife.
- Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf
Riva P Oliveira
Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, Department of Pathology, Harvard Medical School, Harvard Stem Cell Institute, One Joslin Place, Boston, MA 02215, USA
Aging Cell 8:524-41. 2009
..elegans, the transcription regulator SKN-1 is important for oxidative stress resistance and acts in multiple longevity pathways...
- MicroRNAs both promote and antagonize longevity in C. elegans
Alexandre de Lencastre
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511 USA
Curr Biol 20:2159-68. 2010
..elegans, but the mechanisms of life-span regulation are not completely known. MicroRNAs (miRNAs) regulate various aspects of development and metabolism, and one miRNA has been previously implicated in life span...
- Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans
Jeremy M Van Raamsdonk
Department of Biology, McGill University, Montreal, Quebec, Canada
PLoS Genet 5:e1000361. 2009
..Overall, we show that increased oxidative stress caused by deletion of sod genes does not result in decreased lifespan in C. elegans and that deletion of sod-2 extends worm lifespan by altering mitochondrial function...
- Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
Centre for Diabetes and Endocrinology, Department of Medicine, Rayne Institute, University College London, University St, London, UK
FASEB J 22:807-18. 2008
..Thus, enhanced insulin sensitivity is not a prerequisite for IIS mutant longevity. Irs1-/- female mice also displayed normal anterior pituitary function, distinguishing them from long-lived ..
- Genome-wide miRNA signatures of human longevity
Institute of Clinical Molecular Biology, Christian Albrechts University, Schittenhelmstraße 12, D 24105 Kiel, Germany
Aging Cell 11:607-16. 2012
Little is known about the functions of miRNAs in human longevity. Here, we present the first genome-wide miRNA study in long-lived individuals (LLI) who are considered a model for healthy aging...
- The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
Laboratory for Integrative and Systems Physiology, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
Cell 154:430-41. 2013
..genetic or pharmacological restoration of NAD(+) prevents age-associated metabolic decline and promotes longevity in worms. These effects are dependent upon the protein deacetylase sir-2...
- XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity
Rebecca C Taylor
The Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA 94720, USA
Cell 153:1435-47. 2013
..Neuronally derived XBP-1s was sufficient to rescue stress resistance, increase longevity, and activate the UPR(ER) in distal, non-neuronal cell types through a cell-nonautonomous mechanism...
- Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways
David E Shore
Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS Genet 8:e1002792. 2012
..resistance to a variety of stressors, suggesting that cytoprotective mechanisms underpin the regulation of longevity. It has not been established, however, whether the induction of cytoprotective pathways is essential for ..
- Extension of murine life span by overexpression of catalase targeted to mitochondria
Samuel E Schriner
Department of Genome Sciences, University of Washington, Seattle, WA 91895, USA
Science 308:1909-11. 2005
To determine the role of reactive oxygen species in mammalian longevity, we generated transgenic mice that overexpress human catalase localized to the peroxisome, the nucleus, or mitochondria (MCAT)...
- Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination
Nuno M V Gomes
Department of Cell Biology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
Aging Cell 10:761-8. 2011
- Extreme longevity is associated with increased serum thyrotropin
Department of MedicineDivision of Endocrinology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Clin Endocrinol Metab 94:1251-4. 2009
..The distribution of serum TSH shifts progressively to higher concentrations with age...
- Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels
The Jackson Aging Center at The Jackson Laboratory, Bar Harbor, ME 04609, USA
Aging Cell 8:277-87. 2009
..53, P < 0.01). These results support the hypothesis that the IGF1 pathway plays a key role in regulating longevity in mice and indicates that common genetic mechanisms may exist for regulating IGF1 levels and lifespan.
- Two neurons mediate diet-restriction-induced longevity in C. elegans
Nicholas A Bishop
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nature 447:545-9. 2007
..However, no causal role of any hormonal signal in diet-restricted longevity has been demonstrated...
- Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans
Eric L Greer
Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA
Nature 479:365-71. 2011
..Thus, manipulation of specific chromatin modifiers only in parents can induce an epigenetic memory of longevity in descendants.
- OASIS: online application for the survival analysis of lifespan assays performed in aging research
Jae Seong Yang
School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, South Korea
PLoS ONE 6:e23525. 2011
..To capture the different effects of genetic and environmental factors on lifespan, appropriate statistical analyses are needed...
- Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
Section of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Aging Cell 10:686-98. 2011
By studying the loci that contribute to human longevity, we aim to identify mechanisms that contribute to healthy aging...
- Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
Susan J Broughton
Department of Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
Proc Natl Acad Sci U S A 102:3105-10. 2005
..However, the ablated flies show an extension of median and maximal lifespan and increased resistance to oxidative stress and starvation...
- p53 mutant mice that display early ageing-associated phenotypes
Stuart D Tyner
Cell and Molecular Biology Program, Baylor College of Medicine, Houston, TX 77030, USA
Nature 415:45-53. 2002
..As p53+/m mice age, they display an early onset of phenotypes associated with ageing. These include reduced longevity, osteoporosis, generalized organ atrophy and a diminished stress tolerance...
- Demography. Broken limits to life expectancy
Cambridge Group for the History of Population and Social Structure, Cambridge University, Cambridge, CB2 3EN, UK
Science 296:1029-31. 2002
- Cost of mating in Drosophila melanogaster females is mediated by male accessory gland products
ICAPB, University of Edinburgh, UK
Nature 373:241-4. 1995
..The cost of mating to females may therefore represent a side-effect of evolutionary conflict between males...
- 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila
Brian M Zid
California Institute of Technology, Pasadena, CA 91125, USA
Cell 139:149-60. 2009
..For a video summary of this article, see the PaperFlick file with the Supplemental Data available online...
- Delayed ageing through damage protection by the Arf/p53 pathway
Tumor Suppression Group, Spanish National Cancer Research Centre CNIO, Madrid 28029, Spain
Nature 448:375-9. 2007
..These observations extend the protective role of Arf/p53 to ageing, revealing a previously unknown anti-ageing mechanism and providing a rationale for the co-evolution of cancer resistance and longevity.
- Influence of temperature on immature development, survival, longevity, fecundity, and gonotrophic cycles of Aedes albopictus, vector of chikungunya and dengue in the Indian Ocean
Research Unit 016, Institut de recherche pour le developpement IRD, 7 chemin de l IRAT, 97410 Saint Pierre, La Reunion, France
J Med Entomol 46:33-41. 2009
..Therefore, the immature development, survival, longevity, fecundity, and gonotrophic cycles of Ae. albopictus were studied for an F2 population of the IO...
- Lifespan and reproduction in Drosophila: New insights from nutritional geometry
Kwang Pum Lee
School of Biological Sciences and Centre for Mathematical Biology, University of Sydney, Sydney NSW 2006, Australia
Proc Natl Acad Sci U S A 105:2498-503. 2008
..Response surfaces for lifespan and fecundity were maximized at different protein-carbohydrate intakes, with longevity highest at a protein-to-carbohydrate ratio of 1:16 and egg-laying rate maximized at 1:2...
- Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
Eric L Greer
Department of Genetics, Stanford University, Stanford, CA 94305, USA
Aging Cell 8:113-27. 2009
..Here we examine the genetic pathways that mediate longevity by different DR regimens in Caenorhabditis elegans...
- The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
FASEB J 13:1385-93. 1999
b>Longevity is regulated by the daf-2 gene network in Caenorhabditis elegans...
- The p66shc adaptor protein controls oxidative stress response and life span in mammals
Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
Nature 402:309-13. 1999
..We propose that p66shc is part of a signal transduction pathway that regulates stress apoptotic responses and life span in mammals...
- Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study
Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
Eur J Hum Genet 14:79-84. 2006
We conducted a sib pair study in very old subjects for the purpose of mapping longevity loci...
- A database of vertebrate longevity records and their relation to other life-history traits
J P de Magalhaes
School of Biological Sciences, University of Liverpool, Liverpool, UK
J Evol Biol 22:1770-4. 2009
b>Longevity is a major characteristic of animals that has long fascinated scientists...
- Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity
Department of Anesthesia and Perioperative Care, University of California, San Francisco, USA
Aging Cell 8:460-72. 2009
..We found a modest excess of variants nominally associated with longevity. Nominally significant variants were then replicated in two additional Caucasian cohorts including both males ..
- Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens
Danielle A Garsin
Department of Genetics, Massachusetts General Hospital, Boston, MA 02114, USA
Science 300:1921. 2003
- Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA
PLoS Biol 6:e233. 2008
The transcription factor DAF-16/forkhead box O (FOXO) is a critical longevity determinant in diverse organisms, however the molecular basis of how its transcriptional activity is regulated remains largely unknown...
- Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density
Department of Pathology, Yale University School of Medicine, New Haven CT 06520, USA
Aging (Albany NY) 1:131-45. 2009
- Puzzles, promises and a cure for ageing
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA
Nature 454:1065-71. 2008
..A better understanding of the targets of such interventions, as well as the proximate causes of ageing-related degeneration and disease, is essential before we can evaluate if abrogation of human senescence is a realistic prospect...
- Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms
Saula Vigili de Kreutzenberg
Department of Clinical and Experimental Medicine, Metabolic Diseases, University of Padova, Padova, Italy
Diabetes 59:1006-15. 2010
..We also assessed the potential mechanisms linking metabolic alterations to SIRTs in human monocytes (THP-1) in vitro...
- Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Jason G Wood
Department of Pathology, Harvard Medical School, 77 Ave Louis Pasteur, Boston, Massachusetts 02115, USA
Nature 430:686-9. 2004
..Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted. Together these data indicate that STACs slow metazoan ageing by mechanisms that may be related to caloric restriction...
- Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity
Molecular Epidemiology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
Proc Natl Acad Sci U S A 107:18046-9. 2010
..and type 2 diabetes as identified by genome-wide association studies was tested for compatibility with human longevity. Here, we show that nonagenarian siblings from long-lived families and singletons older than 85 y of age from ..
- Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study
Maarten P Rozing
Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
J Am Geriatr Soc 58:564-9. 2010
To explore measures of metabolic syndrome and glucose metabolism in families with exceptional longevity.
- Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition
Mikhail V Blagosklonny
Cell Cycle 5:2087-102. 2006
..animals from worms to mammals caloric restrictions, life-extending agents, and numerous mutations that increase longevity all converge on the TOR pathway...